SEQUENCE LISTING

<110> Hyseq, Inc

<120>  NOVEL NUCLEIC ACIDS AND POLYPEPTIDES

<130>  21272-113 (793)

<140>  NOT YET ASSIGNED
<141>  2001-08-31

<150>  09/654,935
<151>  2000-09-01

<160>  490

      <210> 1
      <211> 1308
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (101)..(1228)

      <400> 1
 acttcttggt actgattgtt tttcccatgc ctcaattggt ttcttttagg gagctacaaa     60

 tttacgggtt cactggtgat tgatcttttc atccagcaca  atg gac aga agt cta     115
                                              Met Asp Arg Ser Leu
                                                1               5

 agg aac gtc ctt gtg gtt tcc ttt ggg ttc ctg ctt ctc ttt aca gcc      163
 Arg Asn Val Leu Val Val Ser Phe Gly Phe Leu Leu Leu Phe Thr Ala
                  10                  15                  20

 tat gga ggt ctg cag agc ctg cag agc agc ctg tac agc gag gag ggc      211
 Tyr Gly Gly Leu Gln Ser Leu Gln Ser Ser Leu Tyr Ser Glu Glu Gly
              25                  30                  35

 ctg ggt gtc aca gcg ctc agc acc ctc tat gga ggc atg ctc ctg tcc      259
 Leu Gly Val Thr Ala Leu Ser Thr Leu Tyr Gly Gly Met Leu Leu Ser
          40                  45                  50

 tcc atg ttc ctc cca ccg ctc ctc atc gag agg ctg ggc tgc aag ggg      307
 Ser Met Phe Leu Pro Pro Leu Leu Ile Glu Arg Leu Gly Cys Lys Gly
      55                  60                  65

 acc atc atc ctc tcc atg tgt ggc tac gtg gcc ttc tcc gtg ggc aac      355
 Thr Ile Ile Leu Ser Met Cys Gly Tyr Val Ala Phe Ser Val Gly Asn
  70                  75                  80                  85

 ttc ttc gcc agc tgg tac act ttg atc ccc acc tcc ata ctg ctg gga      403
 Phe Phe Ala Ser Trp Tyr Thr Leu Ile Pro Thr Ser Ile Leu Leu Gly
                  90                  95                 100

 ctc ggg gcc gcc ccg ctg tgg tct gca cag tgc aca tac ctc acg atc      451
 Leu Gly Ala Ala Pro Leu Trp Ser Ala Gln Cys Thr Tyr Leu Thr Ile
             105                 110                 115

 acg gga aac aca cat gca gag aag gcg gga aag cgt ggc aaa gac atg      499
 Thr Gly Asn Thr His Ala Glu Lys Ala Gly Lys Arg Gly Lys Asp Met
         120                 125                 130

 gtg aac cag tat ttt ggc atc ttc ttc ctc ata ttc cag tca tcc ggt      547
 Val Asn Gln Tyr Phe Gly Ile Phe Phe Leu Ile Phe Gln Ser Ser Gly
     135                 140                 145

 gtg tgg ggc aac ttg atc tca tcg ctg gta ttt ggc cag act ccc agc      595
 Val Trp Gly Asn Leu Ile Ser Ser Leu Val Phe Gly Gln Thr Pro Ser
 150                 155                 160                 165

 caa gag acc ctt cca gaa gag cag ctc acg tcc tgt ggg gcc agt gac      643
 Gln Glu Thr Leu Pro Glu Glu Gln Leu Thr Ser Cys Gly Ala Ser Asp
                 170                 175                 180

 tgc ctg atg gcc acc aca acc acc aac agc acc cag agg ccc tcc cag      691
 Cys Leu Met Ala Thr Thr Thr Thr Asn Ser Thr Gln Arg Pro Ser Gln
             185                 190                 195

 cag ctg gtc tac acc ctc ctg ggc atc tac act ggg agt ggt gtc ctg      739
 Gln Leu Val Tyr Thr Leu Leu Gly Ile Tyr Thr Gly Ser Gly Val Leu
         200                 205                 210

 gct gtc ctg atg ata gct gcg ttc ctc caa ccc ata cga gat gtt cag      787
 Ala Val Leu Met Ile Ala Ala Phe Leu Gln Pro Ile Arg Asp Val Gln
     215                 220                 225

 cgg gaa agt gaa gga gag aag aaa tca gta cct ttc tgg tcc act tta      835
 Arg Glu Ser Glu Gly Glu Lys Lys Ser Val Pro Phe Trp Ser Thr Leu
 230                 235                 240                 245

 ctg tcg act ttc aag cta tat aga gat aaa cgt ctg tgc ctc tta att      883
 Leu Ser Thr Phe Lys Leu Tyr Arg Asp Lys Arg Leu Cys Leu Leu Ile
                 250                 255                 260

 ctg ctg ccg ctg tac agt gga ttg cag caa gga ttc ctc tcc agc gaa      931
 Leu Leu Pro Leu Tyr Ser Gly Leu Gln Gln Gly Phe Leu Ser Ser Glu
             265                 270                 275

 tac aca agg tcc tat gtc acc tgc acc ctg ggc atc cag ttc gtc ggc      979
 Tyr Thr Arg Ser Tyr Val Thr Cys Thr Leu Gly Ile Gln Phe Val Gly
         280                 285                 290

 tac gtg atg atc tgc ttc tcg gcc act gac gcg ctg tgc tcc gtg ttg     1027
 Tyr Val Met Ile Cys Phe Ser Ala Thr Asp Ala Leu Cys Ser Val Leu
     295                 300                 305

 tat gga aag gtc tcg cag tac acg ggc agg gct gtg ctg tac gtg ctg     1075
 Tyr Gly Lys Val Ser Gln Tyr Thr Gly Arg Ala Val Leu Tyr Val Leu
 310                 315                 320                 325

 ggc gcg gtg acc cac gtg tcc tgc atg att gcc cta ctg ctg tgg aga     1123
 Gly Ala Val Thr His Val Ser Cys Met Ile Ala Leu Leu Leu Trp Arg
                 330                 335                 340

 cct cgt gct gac cat ctg gca gtg gtc ttc gta ttc tct ggc ctg tgg     1171
 Pro Arg Ala Asp His Leu Ala Val Val Phe Val Phe Ser Gly Leu Trp
             345                 350                 355

 ggc gtg gca gat gcc gct gca gac aca aaa caa tgc tct cta cgg cgt     1219
 Gly Val Ala Asp Ala Ala Ala Asp Thr Lys Gln Cys Ser Leu Arg Arg
         360                 365                 370

 tct gtt tga gaagaac aagaaactgc ttcgcaatta ccgctgttgg aagcctgggt     1275
 Ser Val 
     375

 tcgtcatgct tgggtacaga gttttgtggt ggg                                1308




      <210> 2
      <211> 3817
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (55)..(2268)

      <400> 2
 cgccggggag gtggagcacg agcgcacgtg ttaggaacct agaaagattg taca  atg      57
                                                              Met
                                                                1

 aat ggt gat tct cgt gct gcg gtg gtg acc tca cca ccc ccg acc aca      105
 Asn Gly Asp Ser Arg Ala Ala Val Val Thr Ser Pro Pro Pro Thr Thr
               5                  10                  15

 gcc cct cac aag gag agg tac ttc gac cga gta gat gag aac aac cca      153
 Ala Pro His Lys Glu Arg Tyr Phe Asp Arg Val Asp Glu Asn Asn Pro
          20                  25                  30

 gag tac ttg agg gag agg aac atg gca cca gac ctt cgc cag gac ttc      201
 Glu Tyr Leu Arg Glu Arg Asn Met Ala Pro Asp Leu Arg Gln Asp Phe
      35                  40                  45

 aac atg atg gag caa aag aag agg gtg tcc atg att ctg caa agc cct      249
 Asn Met Met Glu Gln Lys Lys Arg Val Ser Met Ile Leu Gln Ser Pro
  50                  55                  60                  65

 gct ttc tgt gaa gaa ttg gaa tca atg ata cag gag caa ttt aag aag      297
 Ala Phe Cys Glu Glu Leu Glu Ser Met Ile Gln Glu Gln Phe Lys Lys
                  70                  75                  80

 ggg aag aac ccc aca ggc cta ttg gca tta cag cag att gca gat ttt      345
 Gly Lys Asn Pro Thr Gly Leu Leu Ala Leu Gln Gln Ile Ala Asp Phe
              85                  90                  95

 atg acc acg aat gta cca aat gtc tac cca gca gct ccg caa gga ggg      393
 Met Thr Thr Asn Val Pro Asn Val Tyr Pro Ala Ala Pro Gln Gly Gly
         100                 105                 110

 atg gct gcc tta aac atg agt ctt ggt atg gtg act cct gtg aac gat      441
 Met Ala Ala Leu Asn Met Ser Leu Gly Met Val Thr Pro Val Asn Asp
     115                 120                 125

 ctt aga gga tct gat tct att gcg tat gac aaa gga gag aag tta tta      489
 Leu Arg Gly Ser Asp Ser Ile Ala Tyr Asp Lys Gly Glu Lys Leu Leu
 130                 135                 140                 145

 cgg tgt aaa ttg gca gcg ttt tat aga cta gca gat ctc ttt ggg tgg      537
 Arg Cys Lys Leu Ala Ala Phe Tyr Arg Leu Ala Asp Leu Phe Gly Trp
                 150                 155                 160

 tct cag ctt atc tac aat cat atc aca acc aga gtg aac tcc gag cag      585
 Ser Gln Leu Ile Tyr Asn His Ile Thr Thr Arg Val Asn Ser Glu Gln
             165                 170                 175

 gaa cac ttc ctc att gtc cct ttt ggg ctt ctt tac agt gaa gtg act      633
 Glu His Phe Leu Ile Val Pro Phe Gly Leu Leu Tyr Ser Glu Val Thr
         180                 185                 190

 gca tcc agt ttg gtt aag atc aat cta caa gga gat ata gta gat cgt      681
 Ala Ser Ser Leu Val Lys Ile Asn Leu Gln Gly Asp Ile Val Asp Arg
     195                 200                 205

 gga agc act aat ctg gga gtg aat cag gcc ggc ttc acc tta cac tct      729
 Gly Ser Thr Asn Leu Gly Val Asn Gln Ala Gly Phe Thr Leu His Ser
 210                 215                 220                 225

 gca att tat gct gca cgc ccg gac gtg aag tgc gtc gtg cac att cac      777
 Ala Ile Tyr Ala Ala Arg Pro Asp Val Lys Cys Val Val His Ile His
                 230                 235                 240

 acc cca gca ggg gct gcg gtc tct gca atg aaa tgt ggc ctc ttg cca      825
 Thr Pro Ala Gly Ala Ala Val Ser Ala Met Lys Cys Gly Leu Leu Pro
             245                 250                 255

 atc tcc ccg gag gcg ctt tcc ctt gga gaa gtg gct tat cat gac tac      873
 Ile Ser Pro Glu Ala Leu Ser Leu Gly Glu Val Ala Tyr His Asp Tyr
         260                 265                 270

 cat ggc att ctg gtt gat gaa gag gaa aaa gtt ttg att cag aaa aat      921
 His Gly Ile Leu Val Asp Glu Glu Glu Lys Val Leu Ile Gln Lys Asn
     275                 280                 285

 ctg ggg cct aaa agc aag gtt ctt att ctc cgg aac cat ggg ctc gtg      969
 Leu Gly Pro Lys Ser Lys Val Leu Ile Leu Arg Asn His Gly Leu Val
 290                 295                 300                 305

 tca gtt gga gag agc gtt gag gag gcc ttc tat tac atc cat aac ctt     1017
 Ser Val Gly Glu Ser Val Glu Glu Ala Phe Tyr Tyr Ile His Asn Leu
                 310                 315                 320

 gtg gtt gcc tgt gag atc cag gtt cga act ctg gcc agt gca gga gga     1065
 Val Val Ala Cys Glu Ile Gln Val Arg Thr Leu Ala Ser Ala Gly Gly
             325                 330                 335

 cca gac aac tta gtc ctg ctg aat cct gag aag tac aaa gcc aag tcc     1113
 Pro Asp Asn Leu Val Leu Leu Asn Pro Glu Lys Tyr Lys Ala Lys Ser
         340                 345                 350

 cgt tcc cca ggg tct ccg gta ggg gaa ggc act gga tcg cct ccc aag     1161
 Arg Ser Pro Gly Ser Pro Val Gly Glu Gly Thr Gly Ser Pro Pro Lys
     355                 360                 365

 tgg cag att ggt gag cag gaa ttt gaa gcc ctc atg cgg atg ctc gat     1209
 Trp Gln Ile Gly Glu Gln Glu Phe Glu Ala Leu Met Arg Met Leu Asp
 370                 375                 380                 385

 aat ctg ggc tac aga act ggc tac cct tat cga tac cct gct ctg aga     1257
 Asn Leu Gly Tyr Arg Thr Gly Tyr Pro Tyr Arg Tyr Pro Ala Leu Arg
                 390                 395                 400

 gag aag tct aaa aaa tac agc gat gtg gag gtt cct gct agt gtc aca     1305
 Glu Lys Ser Lys Lys Tyr Ser Asp Val Glu Val Pro Ala Ser Val Thr
             405                 410                 415

 ggt tac tcc ttt gct agt gac ggt gat tcg ggc act tgc tcc cca ctc     1353
 Gly Tyr Ser Phe Ala Ser Asp Gly Asp Ser Gly Thr Cys Ser Pro Leu
         420                 425                 430

 aga cac agt ttt cag aag cag cag cgg gag aag aca aga tgg ctg aac     1401
 Arg His Ser Phe Gln Lys Gln Gln Arg Glu Lys Thr Arg Trp Leu Asn
     435                 440                 445

 tct ggc cgg ggc gac gaa gct tcc gag gaa tgg cag aat gga agc agt     1449
 Ser Gly Arg Gly Asp Glu Ala Ser Glu Glu Trp Gln Asn Gly Ser Ser
 450                 455                 460                 465

 ccc aag tcg aag act aag tgg act aaa gag gat gga cat aga act tcc     1497
 Pro Lys Ser Lys Thr Lys Trp Thr Lys Glu Asp Gly His Arg Thr Ser
                 470                 475                 480

 acc tct gct gtc cct aac ctg ttt gtt cca ttg aac act aac cca aaa     1545
 Thr Ser Ala Val Pro Asn Leu Phe Val Pro Leu Asn Thr Asn Pro Lys
             485                 490                 495

 gag gtc cag gag atg agg aac aag atc cga gag cag aat tta cag gac     1593
 Glu Val Gln Glu Met Arg Asn Lys Ile Arg Glu Gln Asn Leu Gln Asp
         500                 505                 510

 att aag acg gct ggc cct cag tcc cag gtt ttg tgt ggt gta gtg atg     1641
 Ile Lys Thr Ala Gly Pro Gln Ser Gln Val Leu Cys Gly Val Val Met
     515                 520                 525

 gac agg agc ctc gtc cag gga gag ctg gtg acg gcc tcc aag gcc atc     1689
 Asp Arg Ser Leu Val Gln Gly Glu Leu Val Thr Ala Ser Lys Ala Ile
 530                 535                 540                 545

 att gaa aag gag tac cag ccc cac gtc att gtg agc acc acg ggc ccc     1737
 Ile Glu Lys Glu Tyr Gln Pro His Val Ile Val Ser Thr Thr Gly Pro
                 550                 555                 560

 aac ccc ttc acc aca ctc aca gac cgt gag ctg gag gag tac cgc agg     1785
 Asn Pro Phe Thr Thr Leu Thr Asp Arg Glu Leu Glu Glu Tyr Arg Arg
             565                 570                 575

 gag gtg gag agg aag cag aag ggc tct gaa gag aat ctg gac gag gct     1833
 Glu Val Glu Arg Lys Gln Lys Gly Ser Glu Glu Asn Leu Asp Glu Ala
         580                 585                 590

 aga gaa cag aaa gaa aag agt cct cca gac cag cct gcg gtc ccc cac     1881
 Arg Glu Gln Lys Glu Lys Ser Pro Pro Asp Gln Pro Ala Val Pro His
     595                 600                 605

 ccg cct ccc agc act ccc atc aag ctg gag gaa gac ctt gtg ccg gag     1929
 Pro Pro Pro Ser Thr Pro Ile Lys Leu Glu Glu Asp Leu Val Pro Glu
 610                 615                 620                 625

 ccg act act gga gat gac agt gat gct gcc acc ttt aag cca act ctc     1977
 Pro Thr Thr Gly Asp Asp Ser Asp Ala Ala Thr Phe Lys Pro Thr Leu
                 630                 635                 640

 ccc gat ctg tcc cct gat gaa cct tca gaa gca ctc ggc ttc cca atg     2025
 Pro Asp Leu Ser Pro Asp Glu Pro Ser Glu Ala Leu Gly Phe Pro Met
             645                 650                 655

 tta gag aag gag gag gaa gcc cat aga ccc cca agc ccc act gag gcc     2073
 Leu Glu Lys Glu Glu Glu Ala His Arg Pro Pro Ser Pro Thr Glu Ala
         660                 665                 670

 cct act gag gcc agc ccc gag cca gcc cca gac cca gcc ccg gtg gct     2121
 Pro Thr Glu Ala Ser Pro Glu Pro Ala Pro Asp Pro Ala Pro Val Ala
     675                 680                 685

 gaa gag gct gcc ccc tca gct gtc gag gag ggg gcc gcc gcg gac cct     2169
 Glu Glu Ala Ala Pro Ser Ala Val Glu Glu Gly Ala Ala Ala Asp Pro
 690                 695                 700                 705

 ggc agc gat ggg tct cca ggc aag tcc ccg tcc aaa aag aag aag aag     2217
 Gly Ser Asp Gly Ser Pro Gly Lys Ser Pro Ser Lys Lys Lys Lys Lys
                 710                 715                 720

 ttc cgt acc ccg tcc ttt ctg aag aag agc aag aag aag agt gac tcc     2265
 Phe Arg Thr Pro Ser Phe Leu Lys Lys Ser Lys Lys Lys Ser Asp Ser
             725                 730                 735

 tga aagc cctgcgctaa cactgtcctg tccggagcga ccctggctct gccagcgtcc     2322
 


 ccggccacgt ctgtgctctg tccttgtgta atggaatgca aaaaagccaa gccctccgcc   2382

 tagaggtccc ctcacgtgac cagccccgtg tagccccggg ctgacccagt gtgtgctcag   2442

 cagccccacc ccaccctgcc ccttgtcctc tcagagcctc agcttctggg ggagacatgc   2502

 tctccccaca ggggggaggc actaagtcat ggtcctggct ggaaggtact gaaggcttct   2562

 gcagctttgg ctgcacgtca ccctcctgag cctcaccttt cctgccgtcc ctcctgttgt   2622

 gaaatcacca cattctgtct ctgcttggct tcccctccac cctaaagtct caggtgacgg   2682

 actcagactc ctggcttcat gtggcattct ctctgctcag tgatctcact taaatctata   2742

 tacaaagcct tggtcccgtg aaaacactcg tgtgcccacc agcggccttg aagaggcagg   2802

 tctgggccag atgctgggca ggaaacccca gcggcagatg ggcctgtgtg cacccaacgt   2862

 gatgctatgc atgtctgacc gacgatccct cgaccagaat cagattcagg agctcagttt   2922

 ctttttcact tgggtctctg gattcctgtc atagggaagg tatatcagga ggggaagagg   2982

 cctttctaga attttctttg agcaggttta caatttagct tacatttttc gactgtgaac   3042

 gtgaataggc tgctttttgc tttcttcttt ccagacccca cagtagagca cttttcactt   3102

 atttggggga ggcttcaggg gactgttctc accttaactc agccagaaag atgccctagt   3162

 tgtgatcaaa ggtaactcga ggtggagggt agccctgggg cccctcgaca tcaccgtcat   3222

 tgatggagcc tgaaccgtgt gctcctcggc agatgctgtt gttgttactt ccctccaaga   3282

 ggctggaaaa gggctcagag ctgctgagca ggaaccggag ggtgacccat ttcaggaggt   3342

 gccggtacca gcctgactag gtacaggcaa gcttgtgtgg gcccaacagg cccttggtag   3402

 agctggtgcc agatgtgggc tcagatcctg ggcatgatgg gccgagccac ctcggatccc   3462

 actgattggc cagccgagcg agaaccaggc tgctgcatgg cactgaccgc cgcttccagc   3522

 ttcctctgag ccgcagggcc tgctacgcgg gcaagcgtgc tgcctctctt ctgtgtcgtt   3582

 ttgttgccaa ggcagaatga aaagtcctta accgtggact cttcctttat cccctccttt   3642

 accccacata tgcaatgact tttaattttc acttttgtag tttaatcctt tgtattacaa   3702

 catgaaatat agttgcatat atggacaccg acttgggagg acaggtcctg aatgtccttt   3762

 ctccagtgta acatgtttta ctcacaaata aaattctttc agcaaaaaaa aaaaa        3817




      <210> 3
      <211> 3905
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (50)..(2356)

      <400> 3
 gggaggtgga gcacgagcgc acgtgttagg aacctagaaa gattgtaca    atg aat      55
                                                          Met Asn
                                                            1

 ggt gat tct cgt gct gcg gtg gtg acc tca cca ccc ccg acc aca gcc      103
 Gly Asp Ser Arg Ala Ala Val Val Thr Ser Pro Pro Pro Thr Thr Ala
           5                  10                  15

 cct cac aag gag agg tac ttc gac cga gta gat gag aac aac cca gag      151
 Pro His Lys Glu Arg Tyr Phe Asp Arg Val Asp Glu Asn Asn Pro Glu
      20                  25                  30

 tac ttg agg gag agg aac atg gca cca gac ctt cgc cag gac ttc aac      199
 Tyr Leu Arg Glu Arg Asn Met Ala Pro Asp Leu Arg Gln Asp Phe Asn
  35                  40                  45                  50

 atg atg gag caa aag aag agg gtg tcc atg att ctg caa agc cct gct      247
 Met Met Glu Gln Lys Lys Arg Val Ser Met Ile Leu Gln Ser Pro Ala
                  55                  60                  65

 ttc tgt gaa gaa ttg gaa tca atg ata cag gag caa ttt aag aag ggg      295
 Phe Cys Glu Glu Leu Glu Ser Met Ile Gln Glu Gln Phe Lys Lys Gly
              70                  75                  80

 aag aac ccc aca ggc cta ttg gca tta cag cag att gca gat ttt atg      343
 Lys Asn Pro Thr Gly Leu Leu Ala Leu Gln Gln Ile Ala Asp Phe Met
          85                  90                  95

 acc acg aat gta cca aat gtc tac cca gca gct ccg caa gga ggg atg      391
 Thr Thr Asn Val Pro Asn Val Tyr Pro Ala Ala Pro Gln Gly Gly Met
     100                 105                 110

 gct gcc tta aac atg agt ctt ggt atg gtg act cct gtg aac gat ctt      439
 Ala Ala Leu Asn Met Ser Leu Gly Met Val Thr Pro Val Asn Asp Leu
 115                 120                 125                 130

 aga gga tct gat tct att gcg tat gac aaa gga gag aag tta tta cgg      487
 Arg Gly Ser Asp Ser Ile Ala Tyr Asp Lys Gly Glu Lys Leu Leu Arg
                 135                 140                 145

 tgt aaa ttg gca gcg ttt tat aga cta gca gat ctc ttt ggg tgg tct      535
 Cys Lys Leu Ala Ala Phe Tyr Arg Leu Ala Asp Leu Phe Gly Trp Ser
             150                 155                 160

 cag ctt atc tac aat cat atc aca acc aga gtg aac tcc gag cag gaa      583
 Gln Leu Ile Tyr Asn His Ile Thr Thr Arg Val Asn Ser Glu Gln Glu
         165                 170                 175

 cac ttc ctc att gtc cct ttt ggg ctt ctt tac agt gaa gtg act gca      631
 His Phe Leu Ile Val Pro Phe Gly Leu Leu Tyr Ser Glu Val Thr Ala
     180                 185                 190

 tcc agt ttg gtt aag atc aat cta caa gga gat ata gta gat cgt gga      679
 Ser Ser Leu Val Lys Ile Asn Leu Gln Gly Asp Ile Val Asp Arg Gly
 195                 200                 205                 210

 agc act aat ctg gga gtg aat cag gcc ggc ttc acc tta cac tct gca      727
 Ser Thr Asn Leu Gly Val Asn Gln Ala Gly Phe Thr Leu His Ser Ala
                 215                 220                 225

 att tat gct gca cgc ccg gac gtg aag tgc gtc gtg cac att cac acc      775
 Ile Tyr Ala Ala Arg Pro Asp Val Lys Cys Val Val His Ile His Thr
             230                 235                 240

 cca gca ggg gct gcg gtc tct gca atg aaa tgt ggc ctc ttg cca atc      823
 Pro Ala Gly Ala Ala Val Ser Ala Met Lys Cys Gly Leu Leu Pro Ile
         245                 250                 255

 tcc ccg gag gcg ctt tcc ctt gga gaa gtg gct tat cat gac tac cat      871
 Ser Pro Glu Ala Leu Ser Leu Gly Glu Val Ala Tyr His Asp Tyr His
     260                 265                 270

 ggc att ctg gtt gat gaa gag gaa aaa gtt ttg att cag aaa aat ctg      919
 Gly Ile Leu Val Asp Glu Glu Glu Lys Val Leu Ile Gln Lys Asn Leu
 275                 280                 285                 290

 ggg cct aaa agc aag gtt ctt att ctc cgg aac cat ggg ctc gtg tca      967
 Gly Pro Lys Ser Lys Val Leu Ile Leu Arg Asn His Gly Leu Val Ser
                 295                 300                 305

 gtt gga gag agc gtt gag gag gcc ttc tat tac atc cat aac ctt gtg     1015
 Val Gly Glu Ser Val Glu Glu Ala Phe Tyr Tyr Ile His Asn Leu Val
             310                 315                 320

 gtt gcc tgt gag atc cag gtt cga act ctg gcc agt gca gga gga cca     1063
 Val Ala Cys Glu Ile Gln Val Arg Thr Leu Ala Ser Ala Gly Gly Pro
         325                 330                 335

 gac aac tta gtc ctg ctg aat cct gag aag tac aaa gcc aag tcc cgt     1111
 Asp Asn Leu Val Leu Leu Asn Pro Glu Lys Tyr Lys Ala Lys Ser Arg
     340                 345                 350

 tcc cca ggg tct ccg gta ggg gaa ggc act gga tcg cct ccc aag tgg     1159
 Ser Pro Gly Ser Pro Val Gly Glu Gly Thr Gly Ser Pro Pro Lys Trp
 355                 360                 365                 370

 cag att ggt gag cag gaa ttt gaa gcc ctc atg cgg atg ctc gat aat     1207
 Gln Ile Gly Glu Gln Glu Phe Glu Ala Leu Met Arg Met Leu Asp Asn
                 375                 380                 385

 ctg ggc tac aga act ggc tac cct tat cga tac cct gct ctg aga gag     1255
 Leu Gly Tyr Arg Thr Gly Tyr Pro Tyr Arg Tyr Pro Ala Leu Arg Glu
             390                 395                 400

 aag tct aaa aaa tac agc gat gtg gag gtt cct gct agt gtc aca ggt     1303
 Lys Ser Lys Lys Tyr Ser Asp Val Glu Val Pro Ala Ser Val Thr Gly
         405                 410                 415

 tac tcc ttt gct agt gac ggt gat tcg ggc act tgc tcc cca ctc aga     1351
 Tyr Ser Phe Ala Ser Asp Gly Asp Ser Gly Thr Cys Ser Pro Leu Arg
     420                 425                 430

 cac agt ttt cag aag cag cag cgg gag aag aca aga tgg ctg aac tct     1399
 His Ser Phe Gln Lys Gln Gln Arg Glu Lys Thr Arg Trp Leu Asn Ser
 435                 440                 445                 450

 ggc cgg ggc gac gaa gct tcc gag gaa tgg cag aat gga agc agt ccc     1447
 Gly Arg Gly Asp Glu Ala Ser Glu Glu Trp Gln Asn Gly Ser Ser Pro
                 455                 460                 465

 aag tcg aag act aag gtg tgg acg aac att aca cac gat cac gtg aaa     1495
 Lys Ser Lys Thr Lys Val Trp Thr Asn Ile Thr His Asp His Val Lys
             470                 475                 480

 ccc ttg ctg cag tct ctc tcg tcc ggt gtc tgc gtg cca agc tgt att     1543
 Pro Leu Leu Gln Ser Leu Ser Ser Gly Val Cys Val Pro Ser Cys Ile
         485                 490                 495

 acc aac tgc ttg tgg act aaa gag gat gga cat aga act tcc acc tct     1591
 Thr Asn Cys Leu Trp Thr Lys Glu Asp Gly His Arg Thr Ser Thr Ser
     500                 505                 510

 gct gtc cct aac ctg ttt gtt cca ttg aac act aac cca aaa gag gtc     1639
 Ala Val Pro Asn Leu Phe Val Pro Leu Asn Thr Asn Pro Lys Glu Val
 515                 520                 525                 530

 cag gag atg agg aac aag atc cga gag cag aat tta cag gac att aag     1687
 Gln Glu Met Arg Asn Lys Ile Arg Glu Gln Asn Leu Gln Asp Ile Lys
                 535                 540                 545

 acg gct ggc cct cag tcc cag gtt ttg tgt ggt gta gtg atg gac agg     1735
 Thr Ala Gly Pro Gln Ser Gln Val Leu Cys Gly Val Val Met Asp Arg
             550                 555                 560

 agc ctc gtc cag gga gag ctg gtg acg gcc tcc aag gcc atc att gaa     1783
 Ser Leu Val Gln Gly Glu Leu Val Thr Ala Ser Lys Ala Ile Ile Glu
         565                 570                 575

 aag gag tac cag ccc cac gtc att gtg agc acc acg ggc ccc aac ccc     1831
 Lys Glu Tyr Gln Pro His Val Ile Val Ser Thr Thr Gly Pro Asn Pro
     580                 585                 590

 ttc acc aca ctc aca gac cgt gag ctg gag gag tac cgc agg gag gtg     1879
 Phe Thr Thr Leu Thr Asp Arg Glu Leu Glu Glu Tyr Arg Arg Glu Val
 595                 600                 605                 610

 gag agg aag cag aag ggc tct gaa gag aat ctg gac gag gct aga gaa     1927
 Glu Arg Lys Gln Lys Gly Ser Glu Glu Asn Leu Asp Glu Ala Arg Glu
                 615                 620                 625

 cag aaa gaa aag agt cct cca gac cag cct gcg gtc ccc cac ccg cct     1975
 Gln Lys Glu Lys Ser Pro Pro Asp Gln Pro Ala Val Pro His Pro Pro
             630                 635                 640

 ccc agc act ccc atc aag ctg gag gaa gac ctt gtg ccg gag ccg act     2023
 Pro Ser Thr Pro Ile Lys Leu Glu Glu Asp Leu Val Pro Glu Pro Thr
         645                 650                 655

 act gga gat gac agt gat gct gcc acc ttt aag cca act ctc ccc gat     2071
 Thr Gly Asp Asp Ser Asp Ala Ala Thr Phe Lys Pro Thr Leu Pro Asp
     660                 665                 670

 ctg tcc cct gat gaa cct tca gaa gca ctc ggc ttc cca atg tta gag     2119
 Leu Ser Pro Asp Glu Pro Ser Glu Ala Leu Gly Phe Pro Met Leu Glu
 675                 680                 685                 690

 aag gag gag gaa gcc cat aga ccc cca agc ccc act gag gcc cct act     2167
 Lys Glu Glu Glu Ala His Arg Pro Pro Ser Pro Thr Glu Ala Pro Thr
                 695                 700                 705

 gag gcc agc ccc gag cca gcc cca gac cca gcc ccg gtg gct gaa gag     2215
 Glu Ala Ser Pro Glu Pro Ala Pro Asp Pro Ala Pro Val Ala Glu Glu
             710                 715                 720

 gct gcc ccc tca gct gtc gag gag ggg gcc gcc gcg gac cct ggc agc     2263
 Ala Ala Pro Ser Ala Val Glu Glu Gly Ala Ala Ala Asp Pro Gly Ser
         725                 730                 735

 gat ggg tct cca ggc aag tcc ccg tcc aaa aag aag aag aag ttc cgt     2311
 Asp Gly Ser Pro Gly Lys Ser Pro Ser Lys Lys Lys Lys Lys Phe Arg
     740                 745                 750

 acc ccg tcc ttt ctg aag aag agc aag aag aag agt gac tcc tga aag     2359
 Thr Pro Ser Phe Leu Lys Lys Ser Lys Lys Lys Ser Asp Ser 
 755                 760                 765

 ccctgcgcta acactgtcct gtccggagcg accctggctc tgccagcgtc cccggccacg   2419

 tctgtgctct gtccttgtgt aatggaatgc aaaaaagcca agccctccgc ctagaggtcc   2479

 cctcacgtga ccagccccgt gtagccccgg gctgacccag tgtgtgctca gcagccccac   2539

 cccaccctgc cccttgtcct ctcagagcct cagcttctgg gggagacatg ctctccccac   2599

 aggggggagg cactaagtca tggtcctggc tggaaggtac tgaaggcttc tgcagctttg   2659

 gctgcacgtc accctcctga gcctcacctt tcctgccgtc cctcctgttg tgaaatcacc   2719

 acattctgtc tctgcttggc ttcccctcca ccctaaagtc tcaggtgacg gactcagact   2779

 cctggcttca tgtggcattc tctctgctca gtgatctcac ttaaatctat atacaaagcc   2839

 ttggtcccgt gaaaacactc gtgtgcccac cagcggcctt gaagaggcag gtctgggcca   2899

 gatgctgggc aggaaacccc agcggcagat gggcctgtgt gcacccaacg tgatgctatg   2959

 catgtctgac cgacgatccc tcgaccagaa tcagattcag gagctcagtt tctttttcac   3019

 ttgggtctct ggattcctgt catagggaag gtatatcagg aggggaagag gcctttctag   3079

 aattttcttt gagcaggttt acaatttagc ttacattttt cgactgtgaa cgtgaatagg   3139

 ctgctttttg ctttcttctt tccagacccc acagtagagc acttttcact tatttggggg   3199

 aggcttcagg ggactgttct caccttaact cagccagaaa gatgccctag ttgtgatcaa   3259

 aggtaactcg aggtggaggg tagccctggg gcccctcgac atcaccgtca ttgatggagc   3319

 ctgaaccgtg tgctcctcgg cagatgctgt tgttgttact tccctccaag aggctggaaa   3379

 agggctcaga gctgctgagc aggaaccgga gggtgaccca tttcaggagg tgccggtacc   3439

 agcctgacta ggtacaggca agcttgtgtg ggcccaacag gcccttggta gagctggtgc   3499

 cagatgtggg ctcagatcct gggcatgatg ggccgagcca cctcggatcc cactgattgg   3559

 ccagccgagc gagaaccagg ctgctgcatg gcactgaccg ccgcttccag cttcctctga   3619

 gccgcagggc ctgctacgcg ggcaagcgtg ctgcctctct tctgtgtcgt tttgttgcca   3679

 aggcagaatg aaaagtcctt aaccgtggac tcttccttta tcccctcctt taccccacat   3739

 atgcaatgac ttttaatttt cacttttgta gtttaatcct ttgtattaca acatgaaata   3799

 tagttgcata tatggacacc gacttgggag gacaggtcct gaatgtcctt tctccagtgt   3859

 aacatgtttt actcacaaat aaaattcttt cagcaaaaaa aaaaaa                  3905




      <210> 4
      <211> 1255
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (32)..(1255)

      <400> 4
 cacgatttct gtttttgctt ctccaaggaa a   atg gca gct ccc gag cag ccg      52
                                      Met Ala Ala Pro Glu Gln Pro
                                        1               5

 ctt gcg ata tca agg gga tgc acg agc tcc tcc tcg ctt tcc ccg cct      100
 Leu Ala Ile Ser Arg Gly Cys Thr Ser Ser Ser Ser Leu Ser Pro Pro
          10                  15                  20

 cgg ggc gac cga acc ctt ctg gtc agg cac ctg ccg gct gag ctt act      148
 Arg Gly Asp Arg Thr Leu Leu Val Arg His Leu Pro Ala Glu Leu Thr
      25                  30                  35

 gct gag gag aaa gag gac ttg ctg aag tac ttc ggg gct cag tct gtg      196
 Ala Glu Glu Lys Glu Asp Leu Leu Lys Tyr Phe Gly Ala Gln Ser Val
  40                  45                  50                  55

 cgg gtc ctg tca gat aag ggg cga ctg aaa cat aca gct ttt gcc aca      244
 Arg Val Leu Ser Asp Lys Gly Arg Leu Lys His Thr Ala Phe Ala Thr
                  60                  65                  70

 ttc cct aat gaa aaa gca gct ata aag gca ttg aca aga ctc cat caa      292
 Phe Pro Asn Glu Lys Ala Ala Ile Lys Ala Leu Thr Arg Leu His Gln
              75                  80                  85

 ctg aaa ctt tta ggt cat act tta gtc gtt gaa ttt gca aaa gag caa      340
 Leu Lys Leu Leu Gly His Thr Leu Val Val Glu Phe Ala Lys Glu Gln
          90                  95                 100

 gat cga gtt cac tcc cca tgt ccc act tca ggt tct gaa aaa aaa aaa      388
 Asp Arg Val His Ser Pro Cys Pro Thr Ser Gly Ser Glu Lys Lys Lys
     105                 110                 115

 agg tct gat gac cct gtc gaa gat gat aaa gaa aaa aaa gaa ctt ggt      436
 Arg Ser Asp Asp Pro Val Glu Asp Asp Lys Glu Lys Lys Glu Leu Gly
 120                 125                 130                 135

 tat tta aca gta gaa aat gga att gca cca aac cat ggg ctg act ttt      484
 Tyr Leu Thr Val Glu Asn Gly Ile Ala Pro Asn His Gly Leu Thr Phe
                 140                 145                 150

 cct tta aat tca tgc ctc aag tat atg tac cca cca cct tcc agc aca      532
 Pro Leu Asn Ser Cys Leu Lys Tyr Met Tyr Pro Pro Pro Ser Ser Thr
             155                 160                 165

 atc cta gca aac att gta aat gcc ttg gca agc gtg cct aag ttc tat      580
 Ile Leu Ala Asn Ile Val Asn Ala Leu Ala Ser Val Pro Lys Phe Tyr
         170                 175                 180

 gta cag gtc ctt cat ctt atg aat aaa atg aat ttg ccc aca cct ttt      628
 Val Gln Val Leu His Leu Met Asn Lys Met Asn Leu Pro Thr Pro Phe
     185                 190                 195

 gga cca att act gcg cga cct ccc atg tat gaa gac tat atg cca ttg      676
 Gly Pro Ile Thr Ala Arg Pro Pro Met Tyr Glu Asp Tyr Met Pro Leu
 200                 205                 210                 215

 cat gca cct ctt cca ccc aca tct cct cag cca cct gag gaa cct cct      724
 His Ala Pro Leu Pro Pro Thr Ser Pro Gln Pro Pro Glu Glu Pro Pro
                 220                 225                 230

 ttg cca gac gag gat gag gaa tta tct agt gaa gaa tca gaa tat gaa      772
 Leu Pro Asp Glu Asp Glu Glu Leu Ser Ser Glu Glu Ser Glu Tyr Glu
             235                 240                 245

 agc act gat gat gag gac cga cag aga atg aac aaa tta atg gaa cta      820
 Ser Thr Asp Asp Glu Asp Arg Gln Arg Met Asn Lys Leu Met Glu Leu
         250                 255                 260

 gca aat ctt cag ccc aaa aga cct aaa aca ata aag cag cgc cat gtg      868
 Ala Asn Leu Gln Pro Lys Arg Pro Lys Thr Ile Lys Gln Arg His Val
     265                 270                 275

 aga aaa aag aga aaa ata aag gat atg ttg aat aca cct ttg tgt cct      916
 Arg Lys Lys Arg Lys Ile Lys Asp Met Leu Asn Thr Pro Leu Cys Pro
 280                 285                 290                 295

 tca cac agc agt tta cat cca gtg ctg tta cct tca gat gta ttt gac      964
 Ser His Ser Ser Leu His Pro Val Leu Leu Pro Ser Asp Val Phe Asp
                 300                 305                 310

 caa cca caa cct gta ggt aac aaa aga att gaa ttc cat ata tct acc     1012
 Gln Pro Gln Pro Val Gly Asn Lys Arg Ile Glu Phe His Ile Ser Thr
             315                 320                 325

 gac atg cca gct gca ttt aag aaa gat tta gaa aag gaa caa aat tgt     1060
 Asp Met Pro Ala Ala Phe Lys Lys Asp Leu Glu Lys Glu Gln Asn Cys
         330                 335                 340

 gag gaa aaa aat cat gat tta cct gct act gaa gtt gat gca tcc aat     1108
 Glu Glu Lys Asn His Asp Leu Pro Ala Thr Glu Val Asp Ala Ser Asn
     345                 350                 355

 ata gga ttt gga aaa atc ttc ccc aaa cct aat ttg gac atc aca gag     1156
 Ile Gly Phe Gly Lys Ile Phe Pro Lys Pro Asn Leu Asp Ile Thr Glu
 360                 365                 370                 375

 gag att aaa gaa gac tct gat gaa atg cct tca gaa tgt att tct aga     1204
 Glu Ile Lys Glu Asp Ser Asp Glu Met Pro Ser Glu Cys Ile Ser Arg
                 380                 385                 390

 agg gaa ttg gaa aag ggc aga att tct aga gaa ggt aat gtc acg aaa     1252
 Arg Glu Leu Glu Lys Gly Arg Ile Ser Arg Glu Gly Asn Val Thr Lys
             395                 400                 405

 taa                                                                 1255
 






      <210> 5
      <211> 2286
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (609)..(1391)

      <400> 5
 aggcaaacaa acgagttctt tccagcctct gtaaccggat cgctagagcg aaataaactc     60

 gcacaagtgt ccagagatcg tagccagaca gccagcctgc gcttgaacga acttttaagt    120

 gaggctgcaa gagccgccgg gatgtagatt ttagttcgtg gccaagcaca actacgacga    180

 tcctgtccct gccccacccc atccccaaga atgcatggag gaaggagaga ggaagcaggt    240

 gagggccgcc tgcatttctg cacgtcggcg ccggttagaa accctgcagt tttgagagag    300

 aagaagagga gatggagggg ccaggagcca cgactcccgg gagagcgcag ggaggggcgt    360

 gggtgcccct tcgcccacct ccgcccccgt cacctcgaca gctgtcccgc tcttggaatt    420

 cattggcttc ctctacccgg cctcccaaac accaccccaa tctagtttag ccccccgccc    480

 caccctcgct gacctaataa ggccatgcaa gtgtgcgggg gagctacata aaagcgcggg    540

 ctcgcgccga ctctgcacca cgcaggggaa gagaaagcag gagccgtcca gcacggagga    600

 aggcgacc atg gcc aag gag tgg ggc tac gcc agt cac aac ggt cct gac     650
          Met Ala Lys Glu Trp Gly Tyr Ala Ser His Asn Gly Pro Asp
            1               5                  10

 cac tgg cat gaa ctt ttc cca aat gcc aag ggg gaa aac cag tcg ccc      698
 His Trp His Glu Leu Phe Pro Asn Ala Lys Gly Glu Asn Gln Ser Pro
  15                  20                  25                  30

 gtt gag ctg cat act aaa gac atc agg cat gac cct tct ctg cag cca      746
 Val Glu Leu His Thr Lys Asp Ile Arg His Asp Pro Ser Leu Gln Pro
                  35                  40                  45

 tgg tct gtg tct tat gat ggt ggc tct gcc aag acc atc ctg aat aat      794
 Trp Ser Val Ser Tyr Asp Gly Gly Ser Ala Lys Thr Ile Leu Asn Asn
              50                  55                  60

 ggg aag acc tgc cga gtt gta ttt gat gat act tat gat agg tca atg      842
 Gly Lys Thr Cys Arg Val Val Phe Asp Asp Thr Tyr Asp Arg Ser Met
          65                  70                  75

 ctg aga ggg ggt cct ctc cct gga ccc tac cga ctt cgc cag ttt cat      890
 Leu Arg Gly Gly Pro Leu Pro Gly Pro Tyr Arg Leu Arg Gln Phe His
      80                  85                  90

 ctt cac tgg ggc tct tcg gat gat cat ggc tct gag cac acc gtg gat      938
 Leu His Trp Gly Ser Ser Asp Asp His Gly Ser Glu His Thr Val Asp
  95                 100                 105                 110

 gga gtc aag tat gca gcg gag ctt cat ttg gtt cac tgg aac ccg aag      986
 Gly Val Lys Tyr Ala Ala Glu Leu His Leu Val His Trp Asn Pro Lys
                 115                 120                 125

 tat aac act ttt aaa gaa gcc ctg aag cag cgc gat ggg atc gct gtg     1034
 Tyr Asn Thr Phe Lys Glu Ala Leu Lys Gln Arg Asp Gly Ile Ala Val
             130                 135                 140

 att ggc att ttt ctg aag ata gga cat gag aat ggc gag ttc cag att     1082
 Ile Gly Ile Phe Leu Lys Ile Gly His Glu Asn Gly Glu Phe Gln Ile
         145                 150                 155

 ttc ctt gat gca ttg gac aag att aag aca aag ggc aag gag gcg ccc     1130
 Phe Leu Asp Ala Leu Asp Lys Ile Lys Thr Lys Gly Lys Glu Ala Pro
     160                 165                 170

 ttc aca aag ttt gac cca tcc tgc ctg ttc ccg gca tgc cgg gac tac     1178
 Phe Thr Lys Phe Asp Pro Ser Cys Leu Phe Pro Ala Cys Arg Asp Tyr
 175                 180                 185                 190

 tgg acc tac cag ggc tca ttc acc acg ccg ccc tgc gag gaa tgc att     1226
 Trp Thr Tyr Gln Gly Ser Phe Thr Thr Pro Pro Cys Glu Glu Cys Ile
                 195                 200                 205

 gtg tgg ctg ctg ctg aag gag ccc atg acc gtg agc tct gac cag atg     1274
 Val Trp Leu Leu Leu Lys Glu Pro Met Thr Val Ser Ser Asp Gln Met
             210                 215                 220

 gcc aag ctg cgg agc ctc ctc tcc agt gct gag aac gag ccc cca gtg     1322
 Ala Lys Leu Arg Ser Leu Leu Ser Ser Ala Glu Asn Glu Pro Pro Val
         225                 230                 235

 cct ctt gtg agc aac tgg cga cct cca cag cct atc aat aac agg gtg     1370
 Pro Leu Val Ser Asn Trp Arg Pro Pro Gln Pro Ile Asn Asn Arg Val
     240                 245                 250

 gtg aga gct tcc ttc aaa tga gg ctgctggatc ttgccctctt caggaaagga     1423
 Val Arg Ala Ser Phe Lys 
 255                 260

 aacctaccat tggagagctt ggttccttgc ctccttctgg tgctccttac tccaagtcta   1483

 tttcattttt ccacactgag caatgaatgt gagagatgtg gtcaccaaga tctaagttac   1543

 ttgttgaaag aaagttactt tcgacaagat ctaatatgaa agcatagatt tcacatttga   1603

 tctctgtaat aatcatcttt cctataaaag tagcattttt ggtaaagttt caaagaagaa   1663

 gaaacagaga tggaagagta aagatatttt taaaatggct agctattggg caccagtttt   1723

 tctgttatct aaaatttcac acaacttcat tgtttttatt tttatattat gagttgtcca   1783

 tcttaaagaa atatgagtaa ttctacatgt agtagaggtg tatgaagatc atataacaat   1843

 taaacataag ccagaaatta aaatgactat agacagcaag aattgagcta ataatatgtt   1903

 ttaactctta acaccagcaa gaagtcagtc atttattgaa gttttagcta ctaagattac   1963

 ttggttttga ttaccagtga aaagaaaaca caatacaatc aggagttttc aaatttttga   2023

 ttcagtattt gaatttcttc ttcataaatg tagttgaatt tatcctagta tttttcttta   2083

 cctgaagtag ggccatttat ttttaatttc actacatttt tctttgcatg attattaaaa   2143

 taaaaactgc ctctgttgtg tttctcactg gaggctggaa tgaatgatca ctagaacaca   2203

 aaagagtgaa tgatgacact tgaagtcaaa gcagttgtac tgatcaccag aaccaataaa   2263

 gacataaatg gaaaaaaaaa aaa                                           2286




      <210> 6
      <211> 1248
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (346)..(1149)

      <400> 6
 gctcccgggc atttaaaggg gacgcggcgg ctgcccgggg gggatgaggg gcaagtggag     60

 gggacggctc agacgcacat catcctcagt ccctcgggac tggagggact cgtgagccgg    120

 agcccagaaa tccgggggtg gataagacac cgcgtcccct ccaattcccg taagcacccc    180

 ttgctccatc ctgcgcccca atacctcagc tagccccctt ccccacttct tacactccaa    240

 actcagccgg gacagacctc tgctgccgcc gcccccacga acgtgtgacg acggctggag    300

 gccaacagag tccctacagg tggtgctcac ggtaatgcac cgaca    atg agt ggc     354
                                                      Met Ser Gly
                                                        1

 tgt ttt cca gtt tct ggc ctc cgc tgc cta tct agg gac ggc agg atg      402
 Cys Phe Pro Val Ser Gly Leu Arg Cys Leu Ser Arg Asp Gly Arg Met
       5                  10                  15

 gcc gcg cag ggc gcg ccg cgc ttc ctc ctg acc ttc gac ttc gac gag      450
 Ala Ala Gln Gly Ala Pro Arg Phe Leu Leu Thr Phe Asp Phe Asp Glu
  20                  25                  30                  35

 act atc gtg gac gaa aac agc gac gat tcg atc gtg cgc gcc gcg ccg      498
 Thr Ile Val Asp Glu Asn Ser Asp Asp Ser Ile Val Arg Ala Ala Pro
                  40                  45                  50

 ggc cag cgg ctc ccg gag agc ctg cga gcc acc tac cgc gag ggc ttc      546
 Gly Gln Arg Leu Pro Glu Ser Leu Arg Ala Thr Tyr Arg Glu Gly Phe
              55                  60                  65

 tac aac gag tac atg cag cgc gtc ttc aag tac ctg ggc gag cag ggc      594
 Tyr Asn Glu Tyr Met Gln Arg Val Phe Lys Tyr Leu Gly Glu Gln Gly
          70                  75                  80

 gtg cgg ccg cgg gac ctg agc gcc atc tac gaa gcc atc cct ttg tcg      642
 Val Arg Pro Arg Asp Leu Ser Ala Ile Tyr Glu Ala Ile Pro Leu Ser
      85                  90                  95

 cca ggc atg agc gac ctg ctg cag ttt gtg gca aaa cag ggc gcc tgc      690
 Pro Gly Met Ser Asp Leu Leu Gln Phe Val Ala Lys Gln Gly Ala Cys
 100                 105                 110                 115

 ttc gag gtg att ctc atc tcc gat gcc aac acc ttt ggc gtg gag agc      738
 Phe Glu Val Ile Leu Ile Ser Asp Ala Asn Thr Phe Gly Val Glu Ser
                 120                 125                 130

 tcg ctg cgc gcc gcc ggc cac cac agc ctg ttc cgc cgc atc ctc agc      786
 Ser Leu Arg Ala Ala Gly His His Ser Leu Phe Arg Arg Ile Leu Ser
             135                 140                 145

 aac ccg tcg ggg ccg gat gcg cgg gga ctg ctg gct ctg cgg ccg ttc      834
 Asn Pro Ser Gly Pro Asp Ala Arg Gly Leu Leu Ala Leu Arg Pro Phe
         150                 155                 160

 cac aca cac agc tgc gcg cgc tgc ccc gcc aac atg tgc aag cac aag      882
 His Thr His Ser Cys Ala Arg Cys Pro Ala Asn Met Cys Lys His Lys
     165                 170                 175

 gtg ctc agc gac tac ctg cgc gag cgg gcc cac gac ggc gtg cac ttc      930
 Val Leu Ser Asp Tyr Leu Arg Glu Arg Ala His Asp Gly Val His Phe
 180                 185                 190                 195

 gag cgc ctc ttc tac gtg ggc gac ggc gcc aac gac ttc tgc ccc atg      978
 Glu Arg Leu Phe Tyr Val Gly Asp Gly Ala Asn Asp Phe Cys Pro Met
                 200                 205                 210

 ggg ctg ctg gcg ggc ggc gac gtg gcc ttc ccg cgc cgc ggc tac ccc     1026
 Gly Leu Leu Ala Gly Gly Asp Val Ala Phe Pro Arg Arg Gly Tyr Pro
             215                 220                 225

 atg cac cgc ctc att cag gag gcc cag aag gcc gag ccc agc tcg ttc     1074
 Met His Arg Leu Ile Gln Glu Ala Gln Lys Ala Glu Pro Ser Ser Phe
         230                 235                 240

 cgc gcc agc gtg gtg ccc tgg gaa acg gct gca gat gtg cgc ctc cac     1122
 Arg Ala Ser Val Val Pro Trp Glu Thr Ala Ala Asp Val Arg Leu His
     245                 250                 255

 ctg caa cag gtg ctg aag tcg tgc tga gtctg gccgcctgca ggggggtacc     1174
 Leu Gln Gln Val Leu Lys Ser Cys 
 260                 265

 cgggccaacg gcggaggggg cggggaaggg agattcggca aagacagctt tactactccc   1234

 ttaaaaaaaa aaaa                                                     1248




      <210> 7
      <211> 2338
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (154)..(1308)

      <400> 7
 ctcctggcgg ccaggcctgg ggactctctg ccgcgggacg gcgcctcgcg ttccgccgtg     60

 gcagtggccg tggccagaac gtccacgcgc ggtcgtccac cgccggatct cgctccagcg    120

 cccgtggtcc agcgtgtagg gagccgatcg ccc atg gag ggt ctg ggc cgc tcg     174
                                      Met Glu Gly Leu Gly Arg Ser
                                        1               5

 tgc ctg tgg ctg cgt cgg gag ctg tcg ccc ccg cgg ccg cgg ctc ctg      222
 Cys Leu Trp Leu Arg Arg Glu Leu Ser Pro Pro Arg Pro Arg Leu Leu
          10                  15                  20

 ctc ctg gac tgc cgc agc cgc gag ctg tac gag tcg gcg cgc atc ggt      270
 Leu Leu Asp Cys Arg Ser Arg Glu Leu Tyr Glu Ser Ala Arg Ile Gly
      25                  30                  35

 ggg gcg ctg agc gtg gcc ctg ccg gcg ctc ctg ctg cgc cgc ctg cgg      318
 Gly Ala Leu Ser Val Ala Leu Pro Ala Leu Leu Leu Arg Arg Leu Arg
  40                  45                  50                  55

 agg ggc agc ctg tcg gtg cgc gcg ctc ctg cct ggg ccg ccg ctg cag      366
 Arg Gly Ser Leu Ser Val Arg Ala Leu Leu Pro Gly Pro Pro Leu Gln
                  60                  65                  70

 ccg ccc ccg cct gcc ccc gtg ctc ctg tac gac cag ggc ggg ggc cgg      414
 Pro Pro Pro Pro Ala Pro Val Leu Leu Tyr Asp Gln Gly Gly Gly Arg
              75                  80                  85

 cgc cgg cgc ggg gag gcc gag gcc gag gcc gag gag tgg gag gcc gag      462
 Arg Arg Arg Gly Glu Ala Glu Ala Glu Ala Glu Glu Trp Glu Ala Glu
          90                  95                 100

 tcg gtg ctg ggc acc ctg ctg cag aag ctg cga gag gaa ggc tac ctg      510
 Ser Val Leu Gly Thr Leu Leu Gln Lys Leu Arg Glu Glu Gly Tyr Leu
     105                 110                 115

 gcc tac tac ctc cag gga ggc ttc agc aga ttc cag gcc gag tgc cct      558
 Ala Tyr Tyr Leu Gln Gly Gly Phe Ser Arg Phe Gln Ala Glu Cys Pro
 120                 125                 130                 135

 cac ctg tgt gag acc agc ctt gct ggc cgt gcc ggc tcc agc atg gcg      606
 His Leu Cys Glu Thr Ser Leu Ala Gly Arg Ala Gly Ser Ser Met Ala
                 140                 145                 150

 ccg gtg ccc ggt cca gtg ccc gtg gtg ggg ttg ggc agc ctg tgc ctg      654
 Pro Val Pro Gly Pro Val Pro Val Val Gly Leu Gly Ser Leu Cys Leu
             155                 160                 165

 ggc tcc gac tgc tct gat gcg gaa tcc gag gct gac cgc gac tcc atg      702
 Gly Ser Asp Cys Ser Asp Ala Glu Ser Glu Ala Asp Arg Asp Ser Met
         170                 175                 180

 agc tgt ggc ctg gat tcg gag ggt gcc aca ccc cca cca gtg ggg ctg      750
 Ser Cys Gly Leu Asp Ser Glu Gly Ala Thr Pro Pro Pro Val Gly Leu
     185                 190                 195

 cgg gca tcc ttc cct gtc cag atc ctg ccc aac ctc tat ctg ggc agt      798
 Arg Ala Ser Phe Pro Val Gln Ile Leu Pro Asn Leu Tyr Leu Gly Ser
 200                 205                 210                 215

 gcc cgg gat tcc gcc aat ttg gag agc ctg gcc aaa ctg ggc atc cgc      846
 Ala Arg Asp Ser Ala Asn Leu Glu Ser Leu Ala Lys Leu Gly Ile Arg
                 220                 225                 230

 tac atc ctc aat gtc acc ccc aac ctc cca aac ttc ttc gag aag aat      894
 Tyr Ile Leu Asn Val Thr Pro Asn Leu Pro Asn Phe Phe Glu Lys Asn
             235                 240                 245

 ggt gac ttt cac tac aag cag atc ccc atc tcc gac cac tgg agc cag      942
 Gly Asp Phe His Tyr Lys Gln Ile Pro Ile Ser Asp His Trp Ser Gln
         250                 255                 260

 aac ctg tcg cgg ttc ttt ccg gag gcc att gag ttc att gat gag gcc      990
 Asn Leu Ser Arg Phe Phe Pro Glu Ala Ile Glu Phe Ile Asp Glu Ala
     265                 270                 275

 ttg tcc cag aac tgc ggg gtg ctc gtc cac tgc ttg gcg ggg gtc agc     1038
 Leu Ser Gln Asn Cys Gly Val Leu Val His Cys Leu Ala Gly Val Ser
 280                 285                 290                 295

 cgt tct gtc acc gtc act gtg gcc tac ctc atg cag aag ctc cac ctc     1086
 Arg Ser Val Thr Val Thr Val Ala Tyr Leu Met Gln Lys Leu His Leu
                 300                 305                 310

 tct ctc aac gat gcc tat gac ctg gtc aag agg aag aag tct aac atc     1134
 Ser Leu Asn Asp Ala Tyr Asp Leu Val Lys Arg Lys Lys Ser Asn Ile
             315                 320                 325

 tcc ccc aac ttc aac ttc atg ggg cag ttg ctg gac ttt gag cgc agc     1182
 Ser Pro Asn Phe Asn Phe Met Gly Gln Leu Leu Asp Phe Glu Arg Ser
         330                 335                 340

 ttg cgg ctg gag gag cgc cac tcg cag gag cag ggc agt ggg ggg cag     1230
 Leu Arg Leu Glu Glu Arg His Ser Gln Glu Gln Gly Ser Gly Gly Gln
     345                 350                 355

 gca tct gcg gcc tcc aac ccg ccc tcc ttc ttc acc acc ccc acc agt     1278
 Ala Ser Ala Ala Ser Asn Pro Pro Ser Phe Phe Thr Thr Pro Thr Ser
 360                 365                 370                 375

 gat ggc gcc ttc gag ctg gcc ccc acc tag g gccccgtggc cggcaggccg     1329
 Asp Gly Ala Phe Glu Leu Ala Pro Thr 
                 380

 gcccctgccc cacccccacc cacgggtgtc cctgcccact cgtgtggcaa gggaggggag   1389

 ggcaggaggg ctcggcctga gcagggtgct ggggggagag cgcaatacct cacgcgggct   1449

 gccgtcctaa tcaacgtgcc tatggcggga ccacgctcgg agcctgcctc ttctgcgact   1509

 gttacttttt ctttgcggga tgggggtggg ggttccctct ccaggtggtt gtccaggccc   1569

 aggtcccggc cctgggtgct cagccagctc ggctaggccc tgcgcctccc tgcgcttccc   1629

 ccttcaggaa gggtgtgtgc cacctcgttg cactggatcc cagtggctgc ttgggggaga   1689

 ggcgtttgcc atcactggtg ttgtcacctc cctgtttctc caccaagggc ttgggcctct   1749

 cggggctggg gcctcccagg ggatggggac ccagaggtgc agtggccgcc cacatccatg   1809

 gcctaggagc tactgggcag gttcccggcc acacatctgg tgggctgttt tgtttttttt   1869

 ttttcctctt cccccagatg tcttgacggg atcactgggg ctctttgtga gtgagggtgg   1929

 ccaaactacc gccggaggag atggggtctc agagcgagag ctgcggaggg ggaggggaag   1989

 aagaaggcct cacttttgct gctgcggggc ccacacagcc gctgctactt tggggggtgg   2049

 ggaaggggcc aagctgcaga cacacacagt cattcatttc tgtccacacc cctgtgggtg   2109

 gcgggtgtgc gtgtgtgtgc ttgtgtgtgc gcacgtgtcg gcgctcacac acacatgcta   2169

 gcccactgat gcacccagcc cagggctggc agtctttgca gcgtggggcc gtctcaccct   2229

 ggagcctgga gaggatctat gcttgtttgt ttttgtaatc catatcatag ttgctttctt   2289

 taattgttcc ttctgaataa acagtttatt taagataaaa aaaaaaaaa               2338




      <210> 8
      <211> 1037
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (147)..(767)

      <400> 8
 ctagtccccc gcgcggcccc ttattcgctc cgacaaggta caaaaaggct ctggacggcg     60

 gcgtggtagg aggacgggag cgggggcggg aagttccctg aaggagcgag acagggaggg    120

 acagggcaga ggaggagagg aaggcg atg cga cgg aca ggc gca ccc gct cag     173
                              Met Arg Arg Thr Gly Ala Pro Ala Gln
                                1               5

 gct gac tct cgg ggg cga ggt cga gcc agg ggc ggc tgc cct ggg ggc      221
 Ala Asp Ser Arg Gly Arg Gly Arg Ala Arg Gly Gly Cys Pro Gly Gly
  10                  15                  20                  25

 gag gcg acg ctg tct caa cct cca cct cgc ggc gga acc cga gga cag      269
 Glu Ala Thr Leu Ser Gln Pro Pro Pro Arg Gly Gly Thr Arg Gly Gln
                  30                  35                  40

 gag cct cag atg aaa gaa aca atc atg aac cag gaa aaa ctc gcc aaa      317
 Glu Pro Gln Met Lys Glu Thr Ile Met Asn Gln Glu Lys Leu Ala Lys
              45                  50                  55

 ctg cag gca caa gtg cgc att ggt ggg aaa gga act gct cgc aga aag      365
 Leu Gln Ala Gln Val Arg Ile Gly Gly Lys Gly Thr Ala Arg Arg Lys
          60                  65                  70

 aag aag gtg gtt cat aga aca gcc aca gca gat gac aaa aaa ctt cag      413
 Lys Lys Val Val His Arg Thr Ala Thr Ala Asp Asp Lys Lys Leu Gln
      75                  80                  85

 ttc tcc tta aag aag tta ggg gta aac aat atc tct ggt att gaa gag      461
 Phe Ser Leu Lys Lys Leu Gly Val Asn Asn Ile Ser Gly Ile Glu Glu
  90                  95                 100                 105

 gtg aat atg ttt aca aac caa gga aca gtg atc cac ttt aac aac cct      509
 Val Asn Met Phe Thr Asn Gln Gly Thr Val Ile His Phe Asn Asn Pro
                 110                 115                 120

 aaa gtt cag gca tct ctg gca gcg aac act ttc acc att aca ggc cat      557
 Lys Val Gln Ala Ser Leu Ala Ala Asn Thr Phe Thr Ile Thr Gly His
             125                 130                 135

 gct gag acg aag cag ctg aca gaa atg cta ccc agc atc tta aac cag      605
 Ala Glu Thr Lys Gln Leu Thr Glu Met Leu Pro Ser Ile Leu Asn Gln
         140                 145                 150

 ctt ggt gcg gat agt ctg act agt tta agg aga ctg gcc gaa gct ctg      653
 Leu Gly Ala Asp Ser Leu Thr Ser Leu Arg Arg Leu Ala Glu Ala Leu
     155                 160                 165

 ccc aaa caa tct gtg gat gga aaa gca cca ctt gct act gga gag gat      701
 Pro Lys Gln Ser Val Asp Gly Lys Ala Pro Leu Ala Thr Gly Glu Asp
 170                 175                 180                 185

 gat gat gat gaa gtt cca gat ctt gtg gag aat ttt gat gag gct tcc      749
 Asp Asp Asp Glu Val Pro Asp Leu Val Glu Asn Phe Asp Glu Ala Ser
                 190                 195                 200

 aag aat gag gca aac tga attgag tcaacttctg aagataaaac ctgaagaagt      803
 Lys Asn Glu Ala Asn 
             205

 tactgggagc tgctatttta tattatgact gctttttaag aaatttttgt ttatggatct    863

 gataaaatct agatctctaa tatttttaag cccaagcccc ttggacactg cagctctttt    923

 cagtttttgc ttatacacaa ttcattcttt gcagctaatt aagccgaaga agcctgggaa    983

 tcaagtttga aacaaagatt aataaagttc tttgcctagt aaaaaaaaaa aaaa         1037




      <210> 9
      <211> 1138
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (181)..(489)

      <400> 9
 tgttactgta aaatagtttt catctcaccc ctcctaatca tactcccact ttcctgtttg     60

 tgtggtggag ctgctgtttt ttcctttaca tgaattaacc aaatgaattt tgtgtcattg    120

 tttttggggc ttatattttt aaaacataga aattgccttt tgttcatttg aaaagtaagt    180
                                                                 
 atg ttg tat ctg aaa aag ggc tct gcc tct gct ctc cct cgc ttc ctt      228
 Met Leu Tyr Leu Lys Lys Gly Ser Ala Ser Ala Leu Pro Arg Phe Leu
   1               5                  10                  15

 gta acc aat ctc caa acg aat ctc tcc tgg cac cgc ccc ctt cct tat      276
 Val Thr Asn Leu Gln Thr Asn Leu Ser Trp His Arg Pro Leu Pro Tyr
              20                  25                  30

 ata ggg tca ctg tcc ccg ggg cca cct ctg cct cca ccc tgc tgt cac      324
 Ile Gly Ser Leu Ser Pro Gly Pro Pro Leu Pro Pro Pro Cys Cys His
          35                  40                  45

 cac tgc cct ggg cca agg cac cca gga ctc cca gaa agc gcg aga gcc      372
 His Cys Pro Gly Pro Arg His Pro Gly Leu Pro Glu Ser Ala Arg Ala
      50                  55                  60

 agc aag aag gcc cca ctc agc ctt gag act ggt ggt cac acc tcc ctg      420
 Ser Lys Lys Ala Pro Leu Ser Leu Glu Thr Gly Gly His Thr Ser Leu
  65                  70                  75                  80

 tca gag tcg cct gct ggg ctg aag ggg caa tgg att gtc att gtt gaa      468
 Ser Glu Ser Pro Ala Gly Leu Lys Gly Gln Trp Ile Val Ile Val Glu
                  85                  90                  95

 att gtt tgg ctc agg tta taa gg aggaacttgg gaagtagaaa gtgacttgac      521
 Ile Val Trp Leu Arg Leu 
             100

 catgtgcatc cttggtagct tcctgtaact aacaaatgga acagagagca cacccccgcc    581

 ccgccccacc ccaagcagat gttcccgtca gcgctgccct gagtcagtcg gtcccccgtt    641

 tctgctctcc tcccttttgt gttcctgctc acttcaagct tcttccatgg actttccagg    701

 gcacagtcat ctctagcccc caaatcatct cttcatcctc tgtgtgtgca tttttttaac    761

 caaatgaaat agacaagaaa gtcatacttt ggggcagcag aatttctaat ttagtagaat    821

 cactgtatag agatagatgt tgatatatat gtttgtgtat atatatcaaa ccaaattgga    881

 taggagaagt atagctttac agatgaggag aaggagctct ttagaggtcg gagtcaagac    941

 tggtgtcttg gacgtgcatg ggctgtgtcc caggccactc cgcacacatg gggctgaggc   1001

 gtggcgccgg gcccttgtca tccacctcac cacggcagag ccagcaggcc ctgtaaggtg   1061

 ctgctgctgt ctcactgggt cccagcttca agcgcatcag tgggtgacgg gggcaacaaa   1121

 tcagagtgac tggaagt                                                  1138




      <210> 10
      <211> 1189
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (67)..(615)

      <400> 10
 gaatctctga aagactgacc gactgactct gacaggatcc ggggctgagg gaaggaggcg     60

 gcggcc   atg gag ttg ggc gag ctg ctc tac aac aag tct gag tac atc     108
          Met Glu Leu Gly Glu Leu Leu Tyr Asn Lys Ser Glu Tyr Ile
            1               5                  10

 gag acg gca tct ggg aac aaa gtc agt cgc cag tca gtg ttg tgt gga      156
 Glu Thr Ala Ser Gly Asn Lys Val Ser Arg Gln Ser Val Leu Cys Gly
  15                  20                  25                  30

 agc cag aac atc gtt ctc aat ggc aag acc att gtg atg aat gac tgt      204
 Ser Gln Asn Ile Val Leu Asn Gly Lys Thr Ile Val Met Asn Asp Cys
                  35                  40                  45

 att atc cga ggg gat ctg gca aat gta aga gtt gga cgt cat tgt gtt      252
 Ile Ile Arg Gly Asp Leu Ala Asn Val Arg Val Gly Arg His Cys Val
              50                  55                  60

 gtg aaa agt cgt agt gtc ata agg cca cca ttc aag aag ttc agc aaa      300
 Val Lys Ser Arg Ser Val Ile Arg Pro Pro Phe Lys Lys Phe Ser Lys
          65                  70                  75

 ggt gtt gca ttc ttt cct tta cat att gga gac cat gtc ttt att gag      348
 Gly Val Ala Phe Phe Pro Leu His Ile Gly Asp His Val Phe Ile Glu
      80                  85                  90

 gaa gat tgt gtg gtc aac gca gca cag att ggt tcc tat gtt cat gtt      396
 Glu Asp Cys Val Val Asn Ala Ala Gln Ile Gly Ser Tyr Val His Val
  95                 100                 105                 110

 ggg aag aac tgt gtg att ggg cgc cga tgt gtg ttg aaa gac tgc tgc      444
 Gly Lys Asn Cys Val Ile Gly Arg Arg Cys Val Leu Lys Asp Cys Cys
                 115                 120                 125

 aaa att ctt gac aac aca gta tta cct ccg gaa act gtg gtt cca cca      492
 Lys Ile Leu Asp Asn Thr Val Leu Pro Pro Glu Thr Val Val Pro Pro
             130                 135                 140

 ttc act gtc ttc tca ggc tgc cca gga ctc ttc tca ggg gag ctc ccg      540
 Phe Thr Val Phe Ser Gly Cys Pro Gly Leu Phe Ser Gly Glu Leu Pro
         145                 150                 155

 gag tgc act cag gag ctg atg att gac gtc acc aag agc tac tac cag      588
 Glu Cys Thr Gln Glu Leu Met Ile Asp Val Thr Lys Ser Tyr Tyr Gln
     160                 165                 170

 aag ttt ttg ccc ctg acg caa gtc tag catct ctgcctcatg tcttgaatct      640
 Lys Phe Leu Pro Leu Thr Gln Val 
 175                 180

 gcttgagctc taagatgaac ctggggacaa agtgagccag tcagcaccta caaagagctt    700

 ttgtgtcttt gacatctacc accctcctcc ttttaaaaaa tttctttaga atttctcaat    760

 cttcaaggct ctaagtgctt aagaattcac taacagacag accatctgga ggagctgtct    820

 tcaaatgctg tgcttacacc ttatctatga acagtcactt tgtaccatta tctgtggaac    880

 acagaatcat ctgttcccaa cactccagcc ccttggtcct gtggatggct ggatcccgcc    940

 tgaaacggac ctgcagagca gcagcaccct tccggtgtgg aggctatgta gctggtgcgc   1000

 tgctcacggc cattcactgc ccatgctgag cgcctctcac acaggtaatg cccagctttt   1060

 ctgctgctaa cacatttggc cagttgttgc agttgctcat catcttggga aaggtgtttg   1120

 tgacttttca gagcccagat tcctgttgtc tattaaaact tgaagggagg ggtgaataaa   1180

 aaaaaaaaa                                                           1189




      <210> 11
      <211> 4637
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (21)..(4064)

      <400> 11
 accggtccgg aattcccggg    atg ctg ggg cta ggc ttc cgg ggc tct gca      50
                          Met Leu Gly Leu Gly Phe Arg Gly Ser Ala
                            1               5                  10

 gtc ctc ggc gtg tgc tgg cag ctt cgg agc cca ccg agc cgg gcg gct       98
 Val Leu Gly Val Cys Trp Gln Leu Arg Ser Pro Pro Ser Arg Ala Ala
                  15                  20                  25

 agg atg atg aac cgg acg acc ccc gac cag gag ctg gcg cca gcg tcg      146
 Arg Met Met Asn Arg Thr Thr Pro Asp Gln Glu Leu Ala Pro Ala Ser
              30                  35                  40

 gag ccc gtg tgg gag cgg ccg tgg tcg atg gag gag atc cgc agg agc      194
 Glu Pro Val Trp Glu Arg Pro Trp Ser Met Glu Glu Ile Arg Arg Ser
          45                  50                  55

 agc cag agc tgg tcg ctg gcg gcc gac gcg ggc cta cta cag ttt cta      242
 Ser Gln Ser Trp Ser Leu Ala Ala Asp Ala Gly Leu Leu Gln Phe Leu
      60                  65                  70

 cag gaa ttc tca cag caa act atc tct agg acc cat gaa atc aag aaa      290
 Gln Glu Phe Ser Gln Gln Thr Ile Ser Arg Thr His Glu Ile Lys Lys
  75                  80                  85                  90

 caa gtg gac gga cta atc cgg gaa acc aaa gcc aca gat tgt cgc ctg      338
 Gln Val Asp Gly Leu Ile Arg Glu Thr Lys Ala Thr Asp Cys Arg Leu
                  95                 100                 105

 cat aat gtc ttc aat gac ttc ctt atg ctc tct aat acc cag ttc ata      386
 His Asn Val Phe Asn Asp Phe Leu Met Leu Ser Asn Thr Gln Phe Ile
             110                 115                 120

 gag aat cgt gta tat gat gaa gaa gtg gag gag cca gta ctc aag gct      434
 Glu Asn Arg Val Tyr Asp Glu Glu Val Glu Glu Pro Val Leu Lys Ala
         125                 130                 135

 gag gca gaa aaa aca gag cag gag aag aca cga gag cag aaa gaa gta      482
 Glu Ala Glu Lys Thr Glu Gln Glu Lys Thr Arg Glu Gln Lys Glu Val
     140                 145                 150

 gat ctc att cct aaa gtc cag gag gct gtg aac tat ggc tta caa gta      530
 Asp Leu Ile Pro Lys Val Gln Glu Ala Val Asn Tyr Gly Leu Gln Val
 155                 160                 165                 170

 ttg gac agt gcc ttt gag caa ctt gat atc aaa gca gga aac tca gac      578
 Leu Asp Ser Ala Phe Glu Gln Leu Asp Ile Lys Ala Gly Asn Ser Asp
                 175                 180                 185

 tcc gag gaa gat gat gct aat ggg cgg gtg gaa ctg atc ctt gaa cca      626
 Ser Glu Glu Asp Asp Ala Asn Gly Arg Val Glu Leu Ile Leu Glu Pro
             190                 195                 200

 aag gat cta tac att gat cgt cct tta cca tat ctc att ggg tca aag      674
 Lys Asp Leu Tyr Ile Asp Arg Pro Leu Pro Tyr Leu Ile Gly Ser Lys
         205                 210                 215

 ctg ttc atg gaa caa gaa gat gta ggt ctt gga gag ctg tcc agt gaa      722
 Leu Phe Met Glu Gln Glu Asp Val Gly Leu Gly Glu Leu Ser Ser Glu
     220                 225                 230

 gaa ggc tct gta ggc agt gat cgt ggc agt att gtg gac act gag gaa      770
 Glu Gly Ser Val Gly Ser Asp Arg Gly Ser Ile Val Asp Thr Glu Glu
 235                 240                 245                 250

 gag aaa gaa gag gag gag tca gat gaa gat ttt gcc cat cac agt gac      818
 Glu Lys Glu Glu Glu Glu Ser Asp Glu Asp Phe Ala His His Ser Asp
                 255                 260                 265

 aat gaa caa aac cag cac acc aca caa atg agt gat gag gaa gag gat      866
 Asn Glu Gln Asn Gln His Thr Thr Gln Met Ser Asp Glu Glu Glu Asp
             270                 275                 280

 gat gat ggc tgt gac ctt ttt gct gac tct gag aag gag gag gaa gat      914
 Asp Asp Gly Cys Asp Leu Phe Ala Asp Ser Glu Lys Glu Glu Glu Asp
         285                 290                 295

 att gag gac att gaa gaa aat act aga cct aaa aga agc aga cct aca      962
 Ile Glu Asp Ile Glu Glu Asn Thr Arg Pro Lys Arg Ser Arg Pro Thr
     300                 305                 310

 tcg ttt gca gat gag ctg gct gcc cgc atc aag ggg gat gcc atg ggt     1010
 Ser Phe Ala Asp Glu Leu Ala Ala Arg Ile Lys Gly Asp Ala Met Gly
 315                 320                 325                 330

 cga gtg gac gag gag ccg aca acc tta ccc tca gga gaa gca aaa cct     1058
 Arg Val Asp Glu Glu Pro Thr Thr Leu Pro Ser Gly Glu Ala Lys Pro
                 335                 340                 345

 cgg aag aca ctc aaa gag aag aag gaa agg aga act cct tca gac gat     1106
 Arg Lys Thr Leu Lys Glu Lys Lys Glu Arg Arg Thr Pro Ser Asp Asp
             350                 355                 360

 gaa gag gat aac tta ttc gca ccc ccc aag ctg acc gac gag gac ttc     1154
 Glu Glu Asp Asn Leu Phe Ala Pro Pro Lys Leu Thr Asp Glu Asp Phe
         365                 370                 375

 tcg cca ttt ggc tct gga ggt ggc ctg ttc agt ggc ggc aag ggg cta     1202
 Ser Pro Phe Gly Ser Gly Gly Gly Leu Phe Ser Gly Gly Lys Gly Leu
     380                 385                 390

 ttt gat gat gag gac gag gag agt gac ctc ttc acg gaa gcc ccc cag     1250
 Phe Asp Asp Glu Asp Glu Glu Ser Asp Leu Phe Thr Glu Ala Pro Gln
 395                 400                 405                 410

 gat cgg caa gct gga gcc tct gtt aag gag gag tct tca tca tcc aaa     1298
 Asp Arg Gln Ala Gly Ala Ser Val Lys Glu Glu Ser Ser Ser Ser Lys
                 415                 420                 425

 cct gga aag aaa atc cca gca gga gct gtt tct gta ttt tta gga gac     1346
 Pro Gly Lys Lys Ile Pro Ala Gly Ala Val Ser Val Phe Leu Gly Asp
             430                 435                 440

 acg gat gtg ttt ggt gct gcc tcc gtt cca tca atg aag gag cca cag     1394
 Thr Asp Val Phe Gly Ala Ala Ser Val Pro Ser Met Lys Glu Pro Gln
         445                 450                 455

 aag cct gag cag ccc act cca agg aaa agc ccc tat ggt ccc cct ccc     1442
 Lys Pro Glu Gln Pro Thr Pro Arg Lys Ser Pro Tyr Gly Pro Pro Pro
     460                 465                 470

 act ggc ctc ttt gat gat gat gat ggt gat gat gat gac gac ttt ttc     1490
 Thr Gly Leu Phe Asp Asp Asp Asp Gly Asp Asp Asp Asp Asp Phe Phe
 475                 480                 485                 490

 tcg gca ccc cac agc aaa cct tct aaa aca ggc aaa gtc caa tcc act     1538
 Ser Ala Pro His Ser Lys Pro Ser Lys Thr Gly Lys Val Gln Ser Thr
                 495                 500                 505

 gcc gat atc ttt ggt gac gaa gaa gga gat ctg ttc aaa gaa aaa gcc     1586
 Ala Asp Ile Phe Gly Asp Glu Glu Gly Asp Leu Phe Lys Glu Lys Ala
             510                 515                 520

 gta gca tcg cca gaa gcc act gtg agt cag aca gat gaa aat aaa gca     1634
 Val Ala Ser Pro Glu Ala Thr Val Ser Gln Thr Asp Glu Asn Lys Ala
         525                 530                 535

 aga gca gaa aaa aag gtt acc tta tct tcc agc aaa aat ctc aag ccc     1682
 Arg Ala Glu Lys Lys Val Thr Leu Ser Ser Ser Lys Asn Leu Lys Pro
     540                 545                 550

 tca tca gaa aca aag act caa aaa ggc tta ttt tca gat gag gag gac     1730
 Ser Ser Glu Thr Lys Thr Gln Lys Gly Leu Phe Ser Asp Glu Glu Asp
 555                 560                 565                 570

 tct gag gat ttg ttt tct tct caa agt gcg agt aac tta aaa ggt gca     1778
 Ser Glu Asp Leu Phe Ser Ser Gln Ser Ala Ser Asn Leu Lys Gly Ala
                 575                 580                 585

 tct ctg ctg cct ggc aag ctc ccc acg tcg gtt tcc ctg ttt gat gat     1826
 Ser Leu Leu Pro Gly Lys Leu Pro Thr Ser Val Ser Leu Phe Asp Asp
             590                 595                 600

 gaa gat gaa gag gat aat ctt ttt ggg ggt aca gct gct aag aag cag     1874
 Glu Asp Glu Glu Asp Asn Leu Phe Gly Gly Thr Ala Ala Lys Lys Gln
         605                 610                 615

 aca ttg tct cta caa gct cag aga gaa gag aaa gca aaa gcc tcc gag     1922
 Thr Leu Ser Leu Gln Ala Gln Arg Glu Glu Lys Ala Lys Ala Ser Glu
     620                 625                 630

 ctc tcc aaa aag aaa gca tct gcc ctg ttg ttc agc agt gat gag gag     1970
 Leu Ser Lys Lys Lys Ala Ser Ala Leu Leu Phe Ser Ser Asp Glu Glu
 635                 640                 645                 650

 gac cag tgg aat att cct gct tca cag acc cac tta gca tct gac agc     2018
 Asp Gln Trp Asn Ile Pro Ala Ser Gln Thr His Leu Ala Ser Asp Ser
                 655                 660                 665

 agg tct aaa gga gaa ccc agg gat tct ggg acc ctc cag agc cag gag     2066
 Arg Ser Lys Gly Glu Pro Arg Asp Ser Gly Thr Leu Gln Ser Gln Glu
             670                 675                 680

 gcc aag gct gtg aaa aag acc agt ctc ttt gag gaa gac gaa gaa gat     2114
 Ala Lys Ala Val Lys Lys Thr Ser Leu Phe Glu Glu Asp Glu Glu Asp
         685                 690                 695

 gat ctt ttt gcc att gcc aag gac agc caa aag aag acc cag aga gtg     2162
 Asp Leu Phe Ala Ile Ala Lys Asp Ser Gln Lys Lys Thr Gln Arg Val
     700                 705                 710

 tca ctc ctc ttt gaa gac gat gtt gat agc gga ggc tct ctg ttt ggc     2210
 Ser Leu Leu Phe Glu Asp Asp Val Asp Ser Gly Gly Ser Leu Phe Gly
 715                 720                 725                 730

 tct cct ccc aca tct gtt cct cct gca aca aag aaa aaa gag act gtc     2258
 Ser Pro Pro Thr Ser Val Pro Pro Ala Thr Lys Lys Lys Glu Thr Val
                 735                 740                 745

 tct gag gca cca cct ttg ctg ttc agc gat gaa gaa gag aag gag gca     2306
 Ser Glu Ala Pro Pro Leu Leu Phe Ser Asp Glu Glu Glu Lys Glu Ala
             750                 755                 760

 caa ctt gga gtg aag tct gtg gat aag aag gtt gag agt gcc aag gag     2354
 Gln Leu Gly Val Lys Ser Val Asp Lys Lys Val Glu Ser Ala Lys Glu
         765                 770                 775

 tca tta aaa ttt ggg aga act gat gtg gct gag tca gaa aag gaa gga     2402
 Ser Leu Lys Phe Gly Arg Thr Asp Val Ala Glu Ser Glu Lys Glu Gly
     780                 785                 790

 ctt ttg act aga tct gct cag gaa aca gtc aag cat tct gat tta ttt     2450
 Leu Leu Thr Arg Ser Ala Gln Glu Thr Val Lys His Ser Asp Leu Phe
 795                 800                 805                 810

 tct tca tca tcc cca tgg gac aaa gga acc aag cct aga acc aaa act     2498
 Ser Ser Ser Ser Pro Trp Asp Lys Gly Thr Lys Pro Arg Thr Lys Thr
                 815                 820                 825

 gtt ctt agc ttg ttt gat gag gaa gag gat aaa atg gaa gat caa aac     2546
 Val Leu Ser Leu Phe Asp Glu Glu Glu Asp Lys Met Glu Asp Gln Asn
             830                 835                 840

 att atc cag gct cca cag aaa gaa gta gga aag ggc tgc gat cct gat     2594
 Ile Ile Gln Ala Pro Gln Lys Glu Val Gly Lys Gly Cys Asp Pro Asp
         845                 850                 855

 gcc cac ccc aag agc aca ggt gtc ttc cag gat gaa gag ctg ctt ttc     2642
 Ala His Pro Lys Ser Thr Gly Val Phe Gln Asp Glu Glu Leu Leu Phe
     860                 865                 870

 agc cac aag ctc caa aag gac aat gac cca gat gtt gac ctt ttt gct     2690
 Ser His Lys Leu Gln Lys Asp Asn Asp Pro Asp Val Asp Leu Phe Ala
 875                 880                 885                 890

 ggc acc aaa aaa acc aag ctg tta gag cca agt gtt ggg agc ctg ttt     2738
 Gly Thr Lys Lys Thr Lys Leu Leu Glu Pro Ser Val Gly Ser Leu Phe
                 895                 900                 905

 ggg gat gat gaa gat gat gat ctt ttc agc tct gcc aag tcc cag cct     2786
 Gly Asp Asp Glu Asp Asp Asp Leu Phe Ser Ser Ala Lys Ser Gln Pro
             910                 915                 920

 ttg gta caa gag aaa aag aga gta gtg aaa aaa gac cac tct gtt aac     2834
 Leu Val Gln Glu Lys Lys Arg Val Val Lys Lys Asp His Ser Val Asn
         925                 930                 935

 tct ttc aaa aac cag aaa cat cct gaa tcc att caa ggt agt aaa gaa     2882
 Ser Phe Lys Asn Gln Lys His Pro Glu Ser Ile Gln Gly Ser Lys Glu
     940                 945                 950

 aaa ggc ata tgg aag ccg gaa aca cct cag gca aat tta gcg atc aac     2930
 Lys Gly Ile Trp Lys Pro Glu Thr Pro Gln Ala Asn Leu Ala Ile Asn
 955                 960                 965                 970

 cca gcg gcc ttg ctg ccc aca gcg gct tcc cag atc tct gaa gta aag     2978
 Pro Ala Ala Leu Leu Pro Thr Ala Ala Ser Gln Ile Ser Glu Val Lys
                 975                 980                 985

 cct gtt ttg cca gaa ttg gct ttt cct tca tct gaa cac aga agg agc     3026
 Pro Val Leu Pro Glu Leu Ala Phe Pro Ser Ser Glu His Arg Arg Ser
             990                 995                1000

 cac ggt ctg gaa agt gtg cct gtc ctt ccc ggg agt ggg gag gcc ggt     3074
 His Gly Leu Glu Ser Val Pro Val Leu Pro Gly Ser Gly Glu Ala Gly
        1005                1010                1015

 gtg agt ttt gat ctt cca gct cag gca gac acc tta cac agt gca aac     3122
 Val Ser Phe Asp Leu Pro Ala Gln Ala Asp Thr Leu His Ser Ala Asn
    1020                1025                1030

 aag agc cgt gtc aag atg aga ggg aag cgt aga ccg cag acc cgt gca     3170
 Lys Ser Arg Val Lys Met Arg Gly Lys Arg Arg Pro Gln Thr Arg Ala
1035                1040                1045                1050

 gct agg cgg ctg gct gct cag gag tcc agc gag gct gag gac atg agc     3218
 Ala Arg Arg Leu Ala Ala Gln Glu Ser Ser Glu Ala Glu Asp Met Ser
                1055                1060                1065

 atc ccc aga gga ccc att gca cag tgg gct gat ggc gcc att tcc cca     3266
 Ile Pro Arg Gly Pro Ile Ala Gln Trp Ala Asp Gly Ala Ile Ser Pro
            1070                1075                1080

 aat ggc cat cgg cca cag ctc aga gca gcc agt gga gaa gac agc act     3314
 Asn Gly His Arg Pro Gln Leu Arg Ala Ala Ser Gly Glu Asp Ser Thr
        1085                1090                1095

 gag gag gcc ctg gca gct gcc gct gca cct tgg gaa ggt ggt cct gtg     3362
 Glu Glu Ala Leu Ala Ala Ala Ala Ala Pro Trp Glu Gly Gly Pro Val
    1100                1105                1110

 cct gga gtg gac aca agc ccc ttt gca aag tct ctg ggt cat tcc aga     3410
 Pro Gly Val Asp Thr Ser Pro Phe Ala Lys Ser Leu Gly His Ser Arg
1115                1120                1125                1130

 ggg gag gct gac ctt ttt gat tct ggg gac att ttt tcc acg ggc act     3458
 Gly Glu Ala Asp Leu Phe Asp Ser Gly Asp Ile Phe Ser Thr Gly Thr
                1135                1140                1145

 gga tct cag tcc gtg gag aga aca aaa ccc aag gca aag ata gca gag     3506
 Gly Ser Gln Ser Val Glu Arg Thr Lys Pro Lys Ala Lys Ile Ala Glu
            1150                1155                1160

 aat cct gcc aac cca cca gtg ggt ggt aaa gca aag agc ccc atg ttt     3554
 Asn Pro Ala Asn Pro Pro Val Gly Gly Lys Ala Lys Ser Pro Met Phe
        1165                1170                1175

 cct gct cta ggc gag gcc agc agt gat gat gat ctc ttt cag tct gct     3602
 Pro Ala Leu Gly Glu Ala Ser Ser Asp Asp Asp Leu Phe Gln Ser Ala
    1180                1185                1190

 aaa cca aaa cca gca aag aaa aca aat ccc ttt cct ctc ctg gaa gat     3650
 Lys Pro Lys Pro Ala Lys Lys Thr Asn Pro Phe Pro Leu Leu Glu Asp
1195                1200                1205                1210

 gag gat gac ctc ttt aca gat cag aaa gtc aag aag aat gag aca aaa     3698
 Glu Asp Asp Leu Phe Thr Asp Gln Lys Val Lys Lys Asn Glu Thr Lys
                1215                1220                1225

 tcc agt agt cag cag gat gtc ata tta aca aca caa gat att ttt gag     3746
 Ser Ser Ser Gln Gln Asp Val Ile Leu Thr Thr Gln Asp Ile Phe Glu
            1230                1235                1240

 gat gat ata ttt gct acg gaa gca att aaa ccc tct cag aaa acc aga     3794
 Asp Asp Ile Phe Ala Thr Glu Ala Ile Lys Pro Ser Gln Lys Thr Arg
        1245                1250                1255

 gag aag gag aaa aca ttg gaa tct aat tta ttt gat gat aac att gat     3842
 Glu Lys Glu Lys Thr Leu Glu Ser Asn Leu Phe Asp Asp Asn Ile Asp
    1260                1265                1270

 atc ttt gct gac tta act gta aaa cca aaa gaa aag tcc aaa aag aaa     3890
 Ile Phe Ala Asp Leu Thr Val Lys Pro Lys Glu Lys Ser Lys Lys Lys
1275                1280                1285                1290

 gtg gaa gcc aag tct ata ttt gat gat gat atg gat gac atc ttc tcc     3938
 Val Glu Ala Lys Ser Ile Phe Asp Asp Asp Met Asp Asp Ile Phe Ser
                1295                1300                1305

 tct ggt atc cag gct aag aca acc aaa cca aaa agc cga tct gca cag     3986
 Ser Gly Ile Gln Ala Lys Thr Thr Lys Pro Lys Ser Arg Ser Ala Gln
            1310                1315                1320

 gcc gca cct gaa cca aga ttt gaa cac aag gtg tcc aac atc ttt gat     4034
 Ala Ala Pro Glu Pro Arg Phe Glu His Lys Val Ser Asn Ile Phe Asp
        1325                1330                1335

 gat ccc ctg aat gcc ttt gga ggc cag tag a gcacacaggg tatccacatg     4085
 Asp Pro Leu Asn Ala Phe Gly Gly Gln 
    1340                1345

 ttaccctgca gctacattgt tgagttagtg atgatgttgt atatgctgat ggtcttaact   4145

 ggattacaaa aagcaaatac tagaacagct agctcatcgt tcacccaatg tacttggtat   4205

 ttttctgcac tggtttaatc atgcttaata ctacaaaaca aaaataaata tttcacagtg   4265

 gttggtttgt tttgttttta aaccacagtt tgatttagtt agccttgctg gggccataat   4325

 atgcttcagg gtgtgtaaaa gaagaaatct ctttgtggct ttcatgggca gggaatctca   4385

 gagatagcaa atgccacctg accagaagtc tttgttatat ggatgggaac cctaacttag   4445

 ggcttgggca ggggaaagag aaagaagatg agagattata cttcatgagt cttagcaata   4505

 tgggagcagg ttttcactga attctgaggg tgcctctgca tgtcctccaa ggcaaagttt   4565

 ggcaaactgt ggccccccca ctgtcatatt ttgttaataa aattttattg gaacacaaaa   4625

 aaaaaaaaaa aa                                                       4637




      <210> 12
      <211> 4684
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (5)..(4111)

      <400> 12
 cggg atg ctg ggg cta ggc ttc cgg ggc tct gca gtc ctc ggc gtg tgc      49
      Met Leu Gly Leu Gly Phe Arg Gly Ser Ala Val Leu Gly Val Cys
        1               5                  10                  15

 tgg cag ctt cgg agc cca ccg agc cgg gcg gct agg atg atg aac cgg       97
 Trp Gln Leu Arg Ser Pro Pro Ser Arg Ala Ala Arg Met Met Asn Arg
                  20                  25                  30

 acg acc ccc gac cag gag ctg gcg cca gcg tcg gag ccc gtg tgg gag      145
 Thr Thr Pro Asp Gln Glu Leu Ala Pro Ala Ser Glu Pro Val Trp Glu
              35                  40                  45

 cgg ccg tgg tcg atg gag gag atc cgc agg agc agc cag agc tgg tcg      193
 Arg Pro Trp Ser Met Glu Glu Ile Arg Arg Ser Ser Gln Ser Trp Ser
          50                  55                  60

 ctg gcg gcc gac gcg ggc cta cta cag ttt cta cag gaa ttc tca cag      241
 Leu Ala Ala Asp Ala Gly Leu Leu Gln Phe Leu Gln Glu Phe Ser Gln
      65                  70                  75

 caa act atc tct agg acc cat gaa atc aag aaa caa gtg gac gga cta      289
 Gln Thr Ile Ser Arg Thr His Glu Ile Lys Lys Gln Val Asp Gly Leu
  80                  85                  90                  95

 atc cgg gaa acc aaa gcc aca gat tgt cgc ctg cat aat gtc ttc aat      337
 Ile Arg Glu Thr Lys Ala Thr Asp Cys Arg Leu His Asn Val Phe Asn
                 100                 105                 110

 gac ttc ctt atg ctc tct aat acc cag ttc ata gag aat cgt gta tat      385
 Asp Phe Leu Met Leu Ser Asn Thr Gln Phe Ile Glu Asn Arg Val Tyr
             115                 120                 125

 gat gaa gaa gtg gag gag cca gta ctc aag gct gag gca gaa aaa aca      433
 Asp Glu Glu Val Glu Glu Pro Val Leu Lys Ala Glu Ala Glu Lys Thr
         130                 135                 140

 gag cag gag aag aca cga gag cag aaa gaa gta gat ctc att cct aaa      481
 Glu Gln Glu Lys Thr Arg Glu Gln Lys Glu Val Asp Leu Ile Pro Lys
     145                 150                 155

 gtc cag gag gct gtg aac tat ggc tta caa gta ttg gac agt gcc ttt      529
 Val Gln Glu Ala Val Asn Tyr Gly Leu Gln Val Leu Asp Ser Ala Phe
 160                 165                 170                 175

 gag caa ctt gat atc aaa gca gga aac tca gac tcc gag gaa gat gat      577
 Glu Gln Leu Asp Ile Lys Ala Gly Asn Ser Asp Ser Glu Glu Asp Asp
                 180                 185                 190

 gct aat ggg cgg gtg gaa ctg atc ctt gaa cca aag gat cta tac att      625
 Ala Asn Gly Arg Val Glu Leu Ile Leu Glu Pro Lys Asp Leu Tyr Ile
             195                 200                 205

 gat cgt cct tta cca tat ctc att ggg tca aag ctg ttc atg gaa caa      673
 Asp Arg Pro Leu Pro Tyr Leu Ile Gly Ser Lys Leu Phe Met Glu Gln
         210                 215                 220

 gaa gat gta ggt ctt gga gag ctg tcc agt gaa gaa ggc tct gta ggc      721
 Glu Asp Val Gly Leu Gly Glu Leu Ser Ser Glu Glu Gly Ser Val Gly
     225                 230                 235

 agt gat cgt ggc agt att gtg gac act gag gaa gag aaa gaa gag gag      769
 Ser Asp Arg Gly Ser Ile Val Asp Thr Glu Glu Glu Lys Glu Glu Glu
 240                 245                 250                 255

 gag tca gat gaa gat ttt gcc cat cac agt gac aat gaa caa aac cag      817
 Glu Ser Asp Glu Asp Phe Ala His His Ser Asp Asn Glu Gln Asn Gln
                 260                 265                 270

 cac acc aca caa atg agt gat gag gaa gag gat gat gat ggc tgt gac      865
 His Thr Thr Gln Met Ser Asp Glu Glu Glu Asp Asp Asp Gly Cys Asp
             275                 280                 285

 ctt ttt gct gac tct gag aag gag gag gaa gat att gag gac att gaa      913
 Leu Phe Ala Asp Ser Glu Lys Glu Glu Glu Asp Ile Glu Asp Ile Glu
         290                 295                 300

 gaa aat act aga cct aaa aga agc aga cct aca tcg ttt gca gat gag      961
 Glu Asn Thr Arg Pro Lys Arg Ser Arg Pro Thr Ser Phe Ala Asp Glu
     305                 310                 315

 ctg gct gcc cgc atc aag ggg gat gcc atg ggt cga gtg gac gag gag     1009
 Leu Ala Ala Arg Ile Lys Gly Asp Ala Met Gly Arg Val Asp Glu Glu
 320                 325                 330                 335

 ccg aca acc tta ccc tca gga gaa gca aaa cct cgg aag aca ctc aaa     1057
 Pro Thr Thr Leu Pro Ser Gly Glu Ala Lys Pro Arg Lys Thr Leu Lys
                 340                 345                 350

 gag aag aag gaa agg aga act cct tca gac gat gaa gag gat aac tta     1105
 Glu Lys Lys Glu Arg Arg Thr Pro Ser Asp Asp Glu Glu Asp Asn Leu
             355                 360                 365

 ttc gca ccc ccc aag ctg acc gac gag gac ttc tcg cca ttt ggc tct     1153
 Phe Ala Pro Pro Lys Leu Thr Asp Glu Asp Phe Ser Pro Phe Gly Ser
         370                 375                 380

 gga ggt ggc ctg ttc agt ggc ggc aag ggg cta ttt gat gat gag gac     1201
 Gly Gly Gly Leu Phe Ser Gly Gly Lys Gly Leu Phe Asp Asp Glu Asp
     385                 390                 395

 gag gag agt gac ctc ttc acg gaa gcc ccc cag gat cgg caa gct gga     1249
 Glu Glu Ser Asp Leu Phe Thr Glu Ala Pro Gln Asp Arg Gln Ala Gly
 400                 405                 410                 415

 gcc tct gtt aag gag gag tct tca tca tcc aaa cct gga aag aaa atc     1297
 Ala Ser Val Lys Glu Glu Ser Ser Ser Ser Lys Pro Gly Lys Lys Ile
                 420                 425                 430

 cca gca gga gct gtt tct gta ttt tta gga gac acg gat gtg ttt ggt     1345
 Pro Ala Gly Ala Val Ser Val Phe Leu Gly Asp Thr Asp Val Phe Gly
             435                 440                 445

 gct gcc tcc gtt cca tca atg aag gag cca cag aag cct gag cag ccc     1393
 Ala Ala Ser Val Pro Ser Met Lys Glu Pro Gln Lys Pro Glu Gln Pro
         450                 455                 460

 act cca agg aaa agc ccc tat ggt ccc cct ccc act ggc ctc ttt gat     1441
 Thr Pro Arg Lys Ser Pro Tyr Gly Pro Pro Pro Thr Gly Leu Phe Asp
     465                 470                 475

 gat gat gat ggt gat gat gat gac gac ttt ttc tcg gca ccc cac agc     1489
 Asp Asp Asp Gly Asp Asp Asp Asp Asp Phe Phe Ser Ala Pro His Ser
 480                 485                 490                 495

 aaa cct tct aaa aca ggc aaa gtc caa tcc act gcc gat atc ttt ggt     1537
 Lys Pro Ser Lys Thr Gly Lys Val Gln Ser Thr Ala Asp Ile Phe Gly
                 500                 505                 510

 gac gaa gaa gga gat ctg ttc aaa gaa aaa gcc gta gca tcg cca gaa     1585
 Asp Glu Glu Gly Asp Leu Phe Lys Glu Lys Ala Val Ala Ser Pro Glu
             515                 520                 525

 gcc act gtg agt cag aca gat gaa aat aaa gca aga gca gaa aaa aag     1633
 Ala Thr Val Ser Gln Thr Asp Glu Asn Lys Ala Arg Ala Glu Lys Lys
         530                 535                 540

 gtt acc tta tct tcc agc aaa aat ctc aag ccc tca tca gaa aca aag     1681
 Val Thr Leu Ser Ser Ser Lys Asn Leu Lys Pro Ser Ser Glu Thr Lys
     545                 550                 555

 act caa aaa ggc tta ttt tca gat gag gag gac tct gag gat ttg ttt     1729
 Thr Gln Lys Gly Leu Phe Ser Asp Glu Glu Asp Ser Glu Asp Leu Phe
 560                 565                 570                 575

 tct tct caa agt gcg agt aac tta aaa ggt gca tct ctg ctg cct ggc     1777
 Ser Ser Gln Ser Ala Ser Asn Leu Lys Gly Ala Ser Leu Leu Pro Gly
                 580                 585                 590

 aag ctc ccc acg tcg gtt tcc ctg ttt gat gat gaa gat gaa gag gat     1825
 Lys Leu Pro Thr Ser Val Ser Leu Phe Asp Asp Glu Asp Glu Glu Asp
             595                 600                 605

 aat ctt ttt ggg ggt aca gct gct aag aag cag aca ttg tct cta caa     1873
 Asn Leu Phe Gly Gly Thr Ala Ala Lys Lys Gln Thr Leu Ser Leu Gln
         610                 615                 620

 gct cag aga gaa gag aaa gca aaa gcc tcc gag ctc tcc aaa aag aaa     1921
 Ala Gln Arg Glu Glu Lys Ala Lys Ala Ser Glu Leu Ser Lys Lys Lys
     625                 630                 635

 gca tct gcc ctg ttg ttc agc agt gat gag gag gac cag tgg aat att     1969
 Ala Ser Ala Leu Leu Phe Ser Ser Asp Glu Glu Asp Gln Trp Asn Ile
 640                 645                 650                 655

 cct gct tca cag acc cac tta gca tct gac agc agg tct aaa gga gaa     2017
 Pro Ala Ser Gln Thr His Leu Ala Ser Asp Ser Arg Ser Lys Gly Glu
                 660                 665                 670

 ccc agg gat tct ggg acc ctc cag agc cag gag gcc aag gct gtg aaa     2065
 Pro Arg Asp Ser Gly Thr Leu Gln Ser Gln Glu Ala Lys Ala Val Lys
             675                 680                 685

 aag acc agt ctc ttt gag gaa gac gaa gaa gat gat ctt ttt gcc att     2113
 Lys Thr Ser Leu Phe Glu Glu Asp Glu Glu Asp Asp Leu Phe Ala Ile
         690                 695                 700

 gcc aag gac agc caa aag aag acc cag aga gtg tca ctc ctc ttt gaa     2161
 Ala Lys Asp Ser Gln Lys Lys Thr Gln Arg Val Ser Leu Leu Phe Glu
     705                 710                 715

 gac gat gtt gat agc gga ggc tct ctg ttt ggc tct cct ccc aca tct     2209
 Asp Asp Val Asp Ser Gly Gly Ser Leu Phe Gly Ser Pro Pro Thr Ser
 720                 725                 730                 735

 gtt cct cct gca aca aag aaa aaa gag act gtc tct gag gca cca cct     2257
 Val Pro Pro Ala Thr Lys Lys Lys Glu Thr Val Ser Glu Ala Pro Pro
                 740                 745                 750

 ttg ctg ttc agc gat gaa gaa gag aag gag gca caa ctt gga gtg aag     2305
 Leu Leu Phe Ser Asp Glu Glu Glu Lys Glu Ala Gln Leu Gly Val Lys
             755                 760                 765

 tct gtg gat aag aag gtt gag agt gcc aag gag tca tta aaa ttt ggg     2353
 Ser Val Asp Lys Lys Val Glu Ser Ala Lys Glu Ser Leu Lys Phe Gly
         770                 775                 780

 aga act gat gtg gct gag tca gaa aag gaa gga ctt ttg act aga tct     2401
 Arg Thr Asp Val Ala Glu Ser Glu Lys Glu Gly Leu Leu Thr Arg Ser
     785                 790                 795

 gct cag gaa aca gtc aag cat tct gat tta ttt tct tca tca tcc cca     2449
 Ala Gln Glu Thr Val Lys His Ser Asp Leu Phe Ser Ser Ser Ser Pro
 800                 805                 810                 815

 tgg gac aaa gga acc aag cct aga acc aaa act gtt ctt agc ttg ttt     2497
 Trp Asp Lys Gly Thr Lys Pro Arg Thr Lys Thr Val Leu Ser Leu Phe
                 820                 825                 830

 gat gag gaa gag gat aaa atg gaa gat caa aac att atc cag gct cca     2545
 Asp Glu Glu Glu Asp Lys Met Glu Asp Gln Asn Ile Ile Gln Ala Pro
             835                 840                 845

 cag aaa gaa gta gga aag ggc tgc gat cct gat gcc cac ccc aag agc     2593
 Gln Lys Glu Val Gly Lys Gly Cys Asp Pro Asp Ala His Pro Lys Ser
         850                 855                 860

 aca ggt gtc ttc cag gat gaa gag ctg ctt ttc agc cac aag ctc caa     2641
 Thr Gly Val Phe Gln Asp Glu Glu Leu Leu Phe Ser His Lys Leu Gln
     865                 870                 875

 aag gac aat gac cca gat gtt gac ctt ttt gct ggc acc aaa aaa acc     2689
 Lys Asp Asn Asp Pro Asp Val Asp Leu Phe Ala Gly Thr Lys Lys Thr
 880                 885                 890                 895

 aag ctg tta gag cca agt gtt ggg agc ctg ttt ggg gat gat gaa gat     2737
 Lys Leu Leu Glu Pro Ser Val Gly Ser Leu Phe Gly Asp Asp Glu Asp
                 900                 905                 910

 gat gat ctt ttc agc tct gcc aag tcc cag cct ttg gta caa gag aaa     2785
 Asp Asp Leu Phe Ser Ser Ala Lys Ser Gln Pro Leu Val Gln Glu Lys
             915                 920                 925

 aag aga gta gtg aaa aaa gac cac tct gtt aac tct ttc aaa aac cag     2833
 Lys Arg Val Val Lys Lys Asp His Ser Val Asn Ser Phe Lys Asn Gln
         930                 935                 940

 aaa cat cct gaa tcc att caa ggt agt aaa gaa aaa ggc ata tgg aag     2881
 Lys His Pro Glu Ser Ile Gln Gly Ser Lys Glu Lys Gly Ile Trp Lys
     945                 950                 955

 ccg gaa aca cct cag gac tca tca ggt ctc gct cca ttt aaa acc aaa     2929
 Pro Glu Thr Pro Gln Asp Ser Ser Gly Leu Ala Pro Phe Lys Thr Lys
 960                 965                 970                 975

 gaa cca tcc act cgg atc ggg aag ata caa gca aat tta gcg atc aac     2977
 Glu Pro Ser Thr Arg Ile Gly Lys Ile Gln Ala Asn Leu Ala Ile Asn
                 980                 985                 990

 cca gcg gcc ttg ctg ccc aca gcg gct tcc cag atc tct gaa gta aag     3025
 Pro Ala Ala Leu Leu Pro Thr Ala Ala Ser Gln Ile Ser Glu Val Lys
             995                1000                1005

 cct gtt ttg cca gaa ttg gct ttt cct tca tct gaa cac aga agg agc     3073
 Pro Val Leu Pro Glu Leu Ala Phe Pro Ser Ser Glu His Arg Arg Ser
        1010                1015                1020

 cac ggt ctg gaa agt gtg cct gtc ctt ccc ggg agt ggg gag gcc ggt     3121
 His Gly Leu Glu Ser Val Pro Val Leu Pro Gly Ser Gly Glu Ala Gly
    1025                1030                1035

 gtg agt ttt gat ctt cca gct cag gca gac acc tta cac agt gca aac     3169
 Val Ser Phe Asp Leu Pro Ala Gln Ala Asp Thr Leu His Ser Ala Asn
1040                1045                1050                1055

 aag agc cgt gtc aag atg aga ggg aag cgt aga ccg cag acc cgt gca     3217
 Lys Ser Arg Val Lys Met Arg Gly Lys Arg Arg Pro Gln Thr Arg Ala
                1060                1065                1070

 gct agg cgg ctg gct gct cag gag tcc agc gag gct gag gac atg agc     3265
 Ala Arg Arg Leu Ala Ala Gln Glu Ser Ser Glu Ala Glu Asp Met Ser
            1075                1080                1085

 atc ccc aga gga ccc att gca cag tgg gct gat ggc gcc att tcc cca     3313
 Ile Pro Arg Gly Pro Ile Ala Gln Trp Ala Asp Gly Ala Ile Ser Pro
        1090                1095                1100

 aat ggc cat cgg cca cag ctc aga gca gcc agt gga gaa gac agc act     3361
 Asn Gly His Arg Pro Gln Leu Arg Ala Ala Ser Gly Glu Asp Ser Thr
    1105                1110                1115

 gag gag gcc ctg gca gct gcc gct gca cct tgg gaa ggt ggt cct gtg     3409
 Glu Glu Ala Leu Ala Ala Ala Ala Ala Pro Trp Glu Gly Gly Pro Val
1120                1125                1130                1135

 cct gga gtg gac aca agc ccc ttt gca aag tct ctg ggt cat tcc aga     3457
 Pro Gly Val Asp Thr Ser Pro Phe Ala Lys Ser Leu Gly His Ser Arg
                1140                1145                1150

 ggg gag gct gac ctt ttt gat tct ggg gac att ttt tcc acg ggc act     3505
 Gly Glu Ala Asp Leu Phe Asp Ser Gly Asp Ile Phe Ser Thr Gly Thr
            1155                1160                1165

 gga tct cag tcc gtg gag aga aca aaa ccc aag gca aag ata gca gag     3553
 Gly Ser Gln Ser Val Glu Arg Thr Lys Pro Lys Ala Lys Ile Ala Glu
        1170                1175                1180

 aat cct gcc aac cca cca gtg ggt ggt aaa gca aag agc ccc atg ttt     3601
 Asn Pro Ala Asn Pro Pro Val Gly Gly Lys Ala Lys Ser Pro Met Phe
    1185                1190                1195

 cct gct cta ggc gag gcc agc agt gat gat gat ctc ttt cag tct gct     3649
 Pro Ala Leu Gly Glu Ala Ser Ser Asp Asp Asp Leu Phe Gln Ser Ala
1200                1205                1210                1215

 aaa cca aaa cca gca aag aaa aca aat ccc ttt cct ctc ctg gaa gat     3697
 Lys Pro Lys Pro Ala Lys Lys Thr Asn Pro Phe Pro Leu Leu Glu Asp
                1220                1225                1230

 gag gat gac ctc ttt aca gat cag aaa gtc aag aag aat gag aca aaa     3745
 Glu Asp Asp Leu Phe Thr Asp Gln Lys Val Lys Lys Asn Glu Thr Lys
            1235                1240                1245

 tcc agt agt cag cag gat gtc ata tta aca aca caa gat att ttt gag     3793
 Ser Ser Ser Gln Gln Asp Val Ile Leu Thr Thr Gln Asp Ile Phe Glu
        1250                1255                1260

 gat gat ata ttt gct acg gaa gca att aaa ccc tct cag aaa acc aga     3841
 Asp Asp Ile Phe Ala Thr Glu Ala Ile Lys Pro Ser Gln Lys Thr Arg
    1265                1270                1275

 gag aag gag aaa aca ttg gaa tct aat tta ttt gat gat aac att gat     3889
 Glu Lys Glu Lys Thr Leu Glu Ser Asn Leu Phe Asp Asp Asn Ile Asp
1280                1285                1290                1295

 atc ttt gct gac tta act gta aaa cca aaa gaa aag tcc aaa aag aaa     3937
 Ile Phe Ala Asp Leu Thr Val Lys Pro Lys Glu Lys Ser Lys Lys Lys
                1300                1305                1310

 gtg gaa gcc aag tct ata ttt gat gat gat atg gat gac atc ttc tcc     3985
 Val Glu Ala Lys Ser Ile Phe Asp Asp Asp Met Asp Asp Ile Phe Ser
            1315                1320                1325

 tct ggt atc cag gct aag aca acc aaa cca aaa agc cga tct gca cag     4033
 Ser Gly Ile Gln Ala Lys Thr Thr Lys Pro Lys Ser Arg Ser Ala Gln
        1330                1335                1340

 gcc gca cct gaa cca aga ttt gaa cac aag gtg tcc aac atc ttt gat     4081
 Ala Ala Pro Glu Pro Arg Phe Glu His Lys Val Ser Asn Ile Phe Asp
    1345                1350                1355

 gat ccc ctg aat gcc ttt gga ggc cag tag a gcacacaggg tatccacatg     4132
 Asp Pro Leu Asn Ala Phe Gly Gly Gln 
1360                1365

 ttaccctgca gctacattgt tgagttagtg atgatgttgt atatgctgat ggtcttaact   4192

 ggattacaaa aagcaaatac tagaacagct agctcatcgt tcacccaatg tacttggtat   4252

 ttttctgcac tggtttaatc atgcttaata ctacaaaaca aaaataaata tttcacagtg   4312

 gttggtttgt tttgttttta aaccacagtt tgatttagtt agccttgctg gggccataat   4372

 atgcttcagg gtgtgtaaaa gaagaaatct ctttgtggct ttcatgggca gggaatctca   4432

 gagatagcaa atgccacctg accagaagtc tttgttatat ggatgggaac cctaacttag   4492

 ggcttgggca ggggaaagag aaagaagatg agagattata cttcatgagt cttagcaata   4552

 tgggagcagg ttttcactga attctgaggg tgcctctgca tgtcctccaa ggcaaagttt   4612

 ggcaaactgt ggccccccca ctgtcatatt ttgttaataa aattttattg gaacacaaaa   4672

 aaaaaaaaaa aa                                                       4684




      <210> 13
      <211> 1077
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (664)..(1053)

      <400> 13
 tctgagcatc ctgcatggaa gtcaaaggaa atccctttct tggtgacgac ttaaatctgg     60

 gttccctcag acattgggtt gcaccccaac aaatattaaa tggcttcttc ttaaagccca    120

 gagaaagagg ttttttaaaa gactgtcgcc aaatagctga gccaaaaggc tgatcagaat    180

 tcactttttg gaatgtggca gttaaacact accttgatca ttctctcctc tttcctcgag    240

 gaactcctgg agggtttgag cgtctggaaa ctctctgctc tgacccgagg aagcaccctc    300

 ctgacgccgc cttcctccgg ttattgaaag gacgcctcag aaatgctttg ttttctttta    360

 cgatgtattc agaagccttt actgattaaa gttttctttt atttgggtgg ccgggagaga    420

 cccagggagg ttctggaggt tctggaggtt cctttctgtc tcctggcccc accagggatt    480

 tccccatttc tgtttgctgc ctgaaagcag gatgaggaag gccaaggaga gtccttgcac    540

 ccgtgagcgt caggatgagg aaatgacagg aggaagacgt gggtttgggt tagtggctgc    600

 tggcgttttg gcccttggtg tttctggagc ctccagggat ctaggggagc ctgggctgcg    660

 tgc  atg tcg ata agc aga gct gtt ctt ggg gag aag gag gga ggt ctc     708
      Met Ser Ile Ser Arg Ala Val Leu Gly Glu Lys Glu Gly Gly Leu
        1               5                  10                  15

 ggg agt gta gca cca tgc caa cca gcc ctg cgc gaa gac aga gtg agc      756
 Gly Ser Val Ala Pro Cys Gln Pro Ala Leu Arg Glu Asp Arg Val Ser
                  20                  25                  30

 cac gcc cgg atg gca ggg cat gtt tct gtt ttg gtg tct cac ttt cct      804
 His Ala Arg Met Ala Gly His Val Ser Val Leu Val Ser His Phe Pro
              35                  40                  45

 ccc agc gtg act tat ttg ggg att cct cag ggc cta ctg gaa tgt gac      852
 Pro Ser Val Thr Tyr Leu Gly Ile Pro Gln Gly Leu Leu Glu Cys Asp
          50                  55                  60

 tgc cca ctg ccc agc tgc ctc ggg tac aag tcc tgg ccc tat gtc cca      900
 Cys Pro Leu Pro Ser Cys Leu Gly Tyr Lys Ser Trp Pro Tyr Val Pro
      65                  70                  75

 gct gtc agg ggc tca ggg aat cct acc cag cca cct gtc ctg gga tgg      948
 Ala Val Arg Gly Ser Gly Asn Pro Thr Gln Pro Pro Val Leu Gly Trp
  80                  85                  90                  95

 agt gtc agc atc cac ccc ttg gtt gtc atc gag gcc gcc ctc cca gtc      996
 Ser Val Ser Ile His Pro Leu Val Val Ile Glu Ala Ala Leu Pro Val
                 100                 105                 110

 ctg ggt gaa gat att tgg gcc acc agg gct ccc ttg gcc cct tca cgt     1044
 Leu Gly Glu Asp Ile Trp Ala Thr Arg Ala Pro Leu Ala Pro Ser Arg
             115                 120                 125

 agg aaa tag acacgtgctt tttaatgcag gaca                              1077
 Arg Lys 






      <210> 14
      <211> 663
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (18)..(482)

      <400> 14
 cctaccttca gacagag   atg cac ccg gag cct ttg ctc aat tcc aca caa      50
                      Met His Pro Glu Pro Leu Leu Asn Ser Thr Gln
                        1               5                  10

 agt gct cca cac cat ttc cca gac agc ttc cag gcc acc cct ttc tgc       98
 Ser Ala Pro His His Phe Pro Asp Ser Phe Gln Ala Thr Pro Phe Cys
              15                  20                  25

 ttt aac cag agc ctg atc cca gga tca cct tca aat tcc tcc att ctc      146
 Phe Asn Gln Ser Leu Ile Pro Gly Ser Pro Ser Asn Ser Ser Ile Leu
          30                  35                  40

 tct ggc tcc tta gac tac agt tac tcg cca gtg cag ctg cct tca tat      194
 Ser Gly Ser Leu Asp Tyr Ser Tyr Ser Pro Val Gln Leu Pro Ser Tyr
      45                  50                  55

 gct cca gag aat tac aat tcc cct gct tct ctg gac acc aga acc tgt      242
 Ala Pro Glu Asn Tyr Asn Ser Pro Ala Ser Leu Asp Thr Arg Thr Cys
  60                  65                  70                  75

 ggc tac ccc cca gaa gac cat tcc tac caa cac ttg tct tca cac gcc      290
 Gly Tyr Pro Pro Glu Asp His Ser Tyr Gln His Leu Ser Ser His Ala
                  80                  85                  90

 cag tac agc tgc ttc tcc tcg gcc acc acc tcc atc tgc tgc tgc gca      338
 Gln Tyr Ser Cys Phe Ser Ser Ala Thr Thr Ser Ile Cys Cys Cys Ala
              95                 100                 105

 tcg tgt gag gca gag gac ttg gat gct ctc cag gcg gca gag tac ttc      386
 Ser Cys Glu Ala Glu Asp Leu Asp Ala Leu Gln Ala Ala Glu Tyr Phe
         110                 115                 120

 tac ccg agc aca gac tgt gtg gac ttt gcc ccc tca gca gcc gcc acc      434
 Tyr Pro Ser Thr Asp Cys Val Asp Phe Ala Pro Ser Ala Ala Ala Thr
     125                 130                 135

 agt gat ttc tat aag agg gaa aca aac tgt gac atc tgc tat agt taa      482
 Ser Asp Phe Tyr Lys Arg Glu Thr Asn Cys Asp Ile Cys Tyr Ser 
 140                 145                 150

 tagaaattac agtaattcag aacatggcat gggtatatct atttttctac cacgtctaga    542

 tgacactgca aaatatgcaa cttggtaaca caatatccca agcacagttt acatgtcact    602

 atttccaatt ttctgatgct aagcattcat atgaagtcct cagacccggt cacagcgcca    662

 c                                                                    663




      <210> 15
      <211> 970
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (2)..(751)

      <400> 15
 t    atg ccc gga cag agg atc gcc tcg ctg gcc tac tct ctc ctc ccg      46
      Met Pro Gly Gln Arg Ile Ala Ser Leu Ala Tyr Ser Leu Leu Pro
        1               5                  10                  15

 tac ggc gcc gga atc cca gct cca ctt acc agg ccg cgg cta ccc cgc       94
 Tyr Gly Ala Gly Ile Pro Ala Pro Leu Thr Arg Pro Arg Leu Pro Arg
                  20                  25                  30

 cgt ccc ccc cga ctc ccg cca ccc cgc tct ctc agg ctc ttc agg atc      142
 Arg Pro Pro Arg Leu Pro Pro Pro Arg Ser Leu Arg Leu Phe Arg Ile
              35                  40                  45

 caa gtc cgt agg ccc ttt aag ggg tct agt tgc cgt ttg cga ggc cct      190
 Gln Val Arg Arg Pro Phe Lys Gly Ser Ser Cys Arg Leu Arg Gly Pro
          50                  55                  60

 ggg act ttg gtc cca gac agc ggg gat ccg gat ggc ttc cgt gcg gat      238
 Gly Thr Leu Val Pro Asp Ser Gly Asp Pro Asp Gly Phe Arg Ala Asp
      65                  70                  75

 ccg aga ggc caa gga ggg aga ctg tgg aga tat cct gag gct gat tcg      286
 Pro Arg Gly Gln Gly Gly Arg Leu Trp Arg Tyr Pro Glu Ala Asp Ser
  80                  85                  90                  95

 ggt gaa gac tgc agg ccg gag cta gcc gaa ttc gaa aaa ctc tcg gat      334
 Gly Glu Asp Cys Arg Pro Glu Leu Ala Glu Phe Glu Lys Leu Ser Asp
                 100                 105                 110

 cag gtg aag atc agt gaa gaa gcc ctg aga gca gat ggc ttt gga gac      382
 Gln Val Lys Ile Ser Glu Glu Ala Leu Arg Ala Asp Gly Phe Gly Asp
             115                 120                 125

 aat cct ttc tat cac tgt ttg gta gca gag att ctt cca gcg ccc ggg      430
 Asn Pro Phe Tyr His Cys Leu Val Ala Glu Ile Leu Pro Ala Pro Gly
         130                 135                 140

 aag cta ctg ggg ccc tgc gtg gtg ggc tat ggg ata tac tat ttc atc      478
 Lys Leu Leu Gly Pro Cys Val Val Gly Tyr Gly Ile Tyr Tyr Phe Ile
     145                 150                 155

 tac agt aca tgg aag gga cgc acc att tat ctg gag gat atc tat gtg      526
 Tyr Ser Thr Trp Lys Gly Arg Thr Ile Tyr Leu Glu Asp Ile Tyr Val
 160                 165                 170                 175

 atg ccg gaa tat cgg ggt caa ggg att ggt tcc aaa ata atc aaa aag      574
 Met Pro Glu Tyr Arg Gly Gln Gly Ile Gly Ser Lys Ile Ile Lys Lys
                 180                 185                 190

 gtg gct gag gtg gcc ttg gat aag ggc tgc tcc caa ttc cgc ctg gcc      622
 Val Ala Glu Val Ala Leu Asp Lys Gly Cys Ser Gln Phe Arg Leu Ala
             195                 200                 205

 gtc ctg gac tgg aac cag agg gcc atg gac ttg tac aag gcc cta gga      670
 Val Leu Asp Trp Asn Gln Arg Ala Met Asp Leu Tyr Lys Ala Leu Gly
         210                 215                 220

 gcc caa gat ctg acg gaa gct gag ggc tgg cac ttc ttc tgc ttt caa      718
 Ala Gln Asp Leu Thr Glu Ala Glu Gly Trp His Phe Phe Cys Phe Gln
     225                 230                 235

 gga gag gca acg aga aag ttg gca gga aag tga cgccatcc ctaggaggat      769
 Gly Glu Ala Thr Arg Lys Leu Ala Gly Lys 
 240                 245

 ctctgtcttg agtttctcct tccccatcag ctgaagcact cttcagagac tacgtccaca    829

 gacactgatg ctgaggcctc cctggaggaa ggagggttag gggtgcctat cctcaagtat    889

 tggaagagca gaattgaggg agagaccttt cttccttgtt gagggtgaaa aataaataag    949

 aattacatgt caaaaaaaaa a                                              970




      <210> 16
      <211> 640
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (38)..(541)

      <400> 16
 tccggccctt gcgatcaggg cttgaggaac ccgcgcc atg aag tgc gtg ttt gtt      55
                                          Met Lys Cys Val Phe Val
                                            1               5

 acc gta ggg acc acc agc ttt gac gac ctc att gcg tgt gtg tcg gcg      103
 Thr Val Gly Thr Thr Ser Phe Asp Asp Leu Ile Ala Cys Val Ser Ala
              10                  15                  20

 ccc gac agt ctg caa aaa atc gag agc ctt ggt tac aac cga ctt atc      151
 Pro Asp Ser Leu Gln Lys Ile Glu Ser Leu Gly Tyr Asn Arg Leu Ile
          25                  30                  35

 ctg caa att ggt aga gga acg gtg gta cct gaa ccc ttc agt act gag      199
 Leu Gln Ile Gly Arg Gly Thr Val Val Pro Glu Pro Phe Ser Thr Glu
      40                  45                  50

 tcg ttt act ctg gat gtt tac agg tac aag gat tcc ttg aaa gaa gac      247
 Ser Phe Thr Leu Asp Val Tyr Arg Tyr Lys Asp Ser Leu Lys Glu Asp
  55                  60                  65                  70

 att cag aaa gca gat ctt gtt att agt cac gca ggt aaa ggt gca gga      295
 Ile Gln Lys Ala Asp Leu Val Ile Ser His Ala Gly Lys Gly Ala Gly
                  75                  80                  85

 agc tgt ttg gag act ctg gaa aaa gga aag cca ctc gta gtg gtt ata      343
 Ser Cys Leu Glu Thr Leu Glu Lys Gly Lys Pro Leu Val Val Val Ile
              90                  95                 100

 aac gaa aag ttg atg aac aat cat cag ctg gaa ctg gca aag cag cta      391
 Asn Glu Lys Leu Met Asn Asn His Gln Leu Glu Leu Ala Lys Gln Leu
         105                 110                 115

 cac aaa gag ggt cat ctc ttc tat tgt acc tgc agc acg ctt cct ggg      439
 His Lys Glu Gly His Leu Phe Tyr Cys Thr Cys Ser Thr Leu Pro Gly
     120                 125                 130

 ctg tta cag tca atg gac tta tca aca ctg aaa tgt tat cct cct ggc      487
 Leu Leu Gln Ser Met Asp Leu Ser Thr Leu Lys Cys Tyr Pro Pro Gly
 135                 140                 145                 150

 cag cca gaa aaa ttt tct gca ttt ttg gat aaa gtt gtt gga tta caa      535
 Gln Pro Glu Lys Phe Ser Ala Phe Leu Asp Lys Val Val Gly Leu Gln
                 155                 160                 165

 aaa taa acactaaact ctcaacactt taaaagcaac ccccaaattc aacctatgta       591
 Lys 


 atgtgattaa atcaaattaa atacataata tatatttaaa aaaaaaaaa                640




      <210> 17
      <211> 1862
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (375)..(1703)

      <400> 17
 ggaggagacc ctcgacaagc ggaggagcct gagcataccc tcctcgatct acctttcccg     60

 agattctgcc gcaaaaagac cgactggaaa atctcagaac ccgactctac ggctgccttc    120

 tccaactatc cccgagtcta ccgctaggct gttgagcggg ctctcccgct ccgccggacg    180

 tgcaaagcac gcatgcactt ctcccagatt gttttgtcaa tccggggacc tgccttctta    240

 ctctccactc ccgcacagcc cccgttccca aagatctatt ccttcggtgc aagcgcatgt    300

 cattagcatc tcattagctg tccgctcggg ctccggaggc agccaacgcc gccagtctga    360

 ggcaggtgcc cgac  atg gcg agt gta gtg ctg ccg agc gga tcc cag tgt     410
                  Met Ala Ser Val Val Leu Pro Ser Gly Ser Gln Cys
                    1               5                  10

 gcg gcg gca gcg gcg gcg gcg gcg cct ccc ggg ctc cgg ctc cgg ctt      458
 Ala Ala Ala Ala Ala Ala Ala Ala Pro Pro Gly Leu Arg Leu Arg Leu
          15                  20                  25

 ctg ctg ttg ctc ttc tcc gcc gcg gca ctg atc ccc aca ggt gat ggg      506
 Leu Leu Leu Leu Phe Ser Ala Ala Ala Leu Ile Pro Thr Gly Asp Gly
      30                  35                  40

 cag aat ctg ttt acg aaa gac gtg aca gtg atc gag gga gag gtt gcg      554
 Gln Asn Leu Phe Thr Lys Asp Val Thr Val Ile Glu Gly Glu Val Ala
  45                  50                  55                  60

 acc atc agt tgc caa gtc aat aag agt gac gac tct gtg att cag cta      602
 Thr Ile Ser Cys Gln Val Asn Lys Ser Asp Asp Ser Val Ile Gln Leu
                  65                  70                  75

 ctg aat ccc aac agg cag acc att tat ttc agg gac ttc agg cct ttg      650
 Leu Asn Pro Asn Arg Gln Thr Ile Tyr Phe Arg Asp Phe Arg Pro Leu
              80                  85                  90

 aag gac agc agg ttt cag ttg ctg aat ttt tct agc agt gaa ctc aaa      698
 Lys Asp Ser Arg Phe Gln Leu Leu Asn Phe Ser Ser Ser Glu Leu Lys
          95                 100                 105

 gta tca ttg aca aac gtc tca att tct gat gaa gga aga tac ttt tgc      746
 Val Ser Leu Thr Asn Val Ser Ile Ser Asp Glu Gly Arg Tyr Phe Cys
     110                 115                 120

 cag ctc tat acc gat ccc cca cag gaa agt tac acc acc atc aca gtc      794
 Gln Leu Tyr Thr Asp Pro Pro Gln Glu Ser Tyr Thr Thr Ile Thr Val
 125                 130                 135                 140

 ctg gtc cca cca cgt aat ctg atg atc gat atc cag aaa gac act gcg      842
 Leu Val Pro Pro Arg Asn Leu Met Ile Asp Ile Gln Lys Asp Thr Ala
                 145                 150                 155

 gtg gaa ggt gag gag att gaa gtc aac tgc act gct atg gcc agc aag      890
 Val Glu Gly Glu Glu Ile Glu Val Asn Cys Thr Ala Met Ala Ser Lys
             160                 165                 170

 cca gcc acg act atc agg tgg ttc aaa ggg aac aca gag cta aaa ggc      938
 Pro Ala Thr Thr Ile Arg Trp Phe Lys Gly Asn Thr Glu Leu Lys Gly
         175                 180                 185

 aaa tcg gag gtg gaa gag tgg tca gac atg tac act gtg acc agt cag      986
 Lys Ser Glu Val Glu Glu Trp Ser Asp Met Tyr Thr Val Thr Ser Gln
     190                 195                 200

 ctg atg ctg aag gtg cac aag gag gac gat ggg gtc cca gtg atc tgc     1034
 Leu Met Leu Lys Val His Lys Glu Asp Asp Gly Val Pro Val Ile Cys
 205                 210                 215                 220

 cag gtg gag cac cct gcg gtc act gga aac ctg cag acc cag cgg tat     1082
 Gln Val Glu His Pro Ala Val Thr Gly Asn Leu Gln Thr Gln Arg Tyr
                 225                 230                 235

 cta gaa gta cag tat aag cct caa gtg cac att cag atg act tat cct     1130
 Leu Glu Val Gln Tyr Lys Pro Gln Val His Ile Gln Met Thr Tyr Pro
             240                 245                 250

 cta caa ggc tta acc cgg gaa ggg gac gcg ctt gag tta aca tgt gaa     1178
 Leu Gln Gly Leu Thr Arg Glu Gly Asp Ala Leu Glu Leu Thr Cys Glu
         255                 260                 265

 gcc atc ggg aag ccc cag cct gtg atg gta act tgg gtg aga gtc gat     1226
 Ala Ile Gly Lys Pro Gln Pro Val Met Val Thr Trp Val Arg Val Asp
     270                 275                 280

 gat gaa atg cct caa cac gcc gta ctg tct ggg ccc aac ctg ttc atc     1274
 Asp Glu Met Pro Gln His Ala Val Leu Ser Gly Pro Asn Leu Phe Ile
 285                 290                 295                 300

 aat aac cta aac aaa aca gat aat ggt aca tac cgc tgt gaa gct tca     1322
 Asn Asn Leu Asn Lys Thr Asp Asn Gly Thr Tyr Arg Cys Glu Ala Ser
                 305                 310                 315

 aac ata gtg ggg aaa gct cac tcg gat tat atg ctg tat gta tac gat     1370
 Asn Ile Val Gly Lys Ala His Ser Asp Tyr Met Leu Tyr Val Tyr Asp
             320                 325                 330

 ccc ccc aca act atc cct cct ccc aca aca acc acc acc acc acc acc     1418
 Pro Pro Thr Thr Ile Pro Pro Pro Thr Thr Thr Thr Thr Thr Thr Thr
         335                 340                 345

 acc acc acc acc acc atc ctt acc atc atc aca gat tcc cga gca ggt     1466
 Thr Thr Thr Thr Thr Ile Leu Thr Ile Ile Thr Asp Ser Arg Ala Gly
     350                 355                 360

 gaa gaa ggc tcg atc agg gca gtg gat cat gcc gtg atc ggt ggc gtc     1514
 Glu Glu Gly Ser Ile Arg Ala Val Asp His Ala Val Ile Gly Gly Val
 365                 370                 375                 380

 gtg gcg gtg gtg gtg ttc gcc atg ctg tgc ttg ctc atc att ctg ggg     1562
 Val Ala Val Val Val Phe Ala Met Leu Cys Leu Leu Ile Ile Leu Gly
                 385                 390                 395

 cgc tat ttt gcc aga cat aaa ggt aca tac ttc act cat gaa gcc aaa     1610
 Arg Tyr Phe Ala Arg His Lys Gly Thr Tyr Phe Thr His Glu Ala Lys
             400                 405                 410

 gga gcc gat gac gca gca gac gca gac aca gct ata atc aat gca gaa     1658
 Gly Ala Asp Asp Ala Ala Asp Ala Asp Thr Ala Ile Ile Asn Ala Glu
         415                 420                 425

 gga gga cag aac aac tcc gaa gaa aag aaa gag tac ttc atc tag atc     1706
 Gly Gly Gln Asn Asn Ser Glu Glu Lys Lys Glu Tyr Phe Ile 
     430                 435                 440

 agcctttttg tttcaatgag gtgtccaact ggccctattt agatgataaa gagacagtga   1766

 tattggaact tgcgagaaat tcgtgtgttt ttttatgaat gggtggaaag gtgtgagact   1826

 gggaaggctt gggatttgct gtgtaaaaaa aaaaaa                             1862




      <210> 18
      <211> 453
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (106)..(294)

      <400> 18
 tcctgattct ggagcgtctt gtttccagcc ctctgtccgc cttccacgtg cacccactgc     60

 ctcttccctt ctcgcttggg aactctagtc tcgcctcggg ttgca    atg gac ccc     114
                                                      Met Asp Pro
                                                        1

 aac tgc tcc tgt gcc gct gca ggt gtc tcc tgc acc tgc gcc agc tcc      162
 Asn Cys Ser Cys Ala Ala Ala Gly Val Ser Cys Thr Cys Ala Ser Ser
       5                  10                  15

 tgc aag tgc aaa gag tgc aaa tgc acc tcc tgc aag aag agc tgc tgc      210
 Cys Lys Cys Lys Glu Cys Lys Cys Thr Ser Cys Lys Lys Ser Cys Cys
  20                  25                  30                  35

 tcc tgc tgc cct gtg ggc tgt gcc aag tgt gcc cag ggc tgc atc tgc      258
 Ser Cys Cys Pro Val Gly Cys Ala Lys Cys Ala Gln Gly Cys Ile Cys
                  40                  45                  50

 aaa ggg gca tcg gag aag tgc agc tgc tgc gcc tga tgtc gggacagccc      308
 Lys Gly Ala Ser Glu Lys Cys Ser Cys Cys Ala 
              55                  60

 tgctcccaag tacaaataga gtgacccgta aaatccagga ttttttgttt tttgctacaa    368

 tcttgacccc tttgctacat tccttttttt ctgtgaaata tgtgaataat aattaaacac    428

 ttagacttga ttccaaaaaa aaaaa                                          453




      <210> 19
      <211> 2189
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (128)..(2050)

      <400> 19
 ggctgctccc ggacaagggc aacgagcgtt tcgtttggac ttctcgactt gagtgcccgc     60

 ctccttcgcc gccgcctctg cagtcctcag cgcagtcttt ccacaggagc cagcatactt    120

 cctgaac  atg gag agt gtt gtt cgc cgc tgc cca ttc tta tcc cga gtc     169
          Met Glu Ser Val Val Arg Arg Cys Pro Phe Leu Ser Arg Val
            1               5                  10

 ccc cag gcc ttt ctg cag aaa gca ggc aaa tct ctg ttg ttc tat gcc      217
 Pro Gln Ala Phe Leu Gln Lys Ala Gly Lys Ser Leu Leu Phe Tyr Ala
  15                  20                  25                  30

 caa aac tgc ccc aag atg atg gaa gtt ggg gcc aag cca gcc cct cgg      265
 Gln Asn Cys Pro Lys Met Met Glu Val Gly Ala Lys Pro Ala Pro Arg
                  35                  40                  45

 gca ttg tcc act gca gca gta cac tac caa cag atc aaa gaa acc cct      313
 Ala Leu Ser Thr Ala Ala Val His Tyr Gln Gln Ile Lys Glu Thr Pro
              50                  55                  60

 ccg gcc agt gag aaa gac aaa act gct aag gcc aag gtc caa cag act      361
 Pro Ala Ser Glu Lys Asp Lys Thr Ala Lys Ala Lys Val Gln Gln Thr
          65                  70                  75

 cct gat gga tcc cag cag agt cca gat ggc aca cag ctt ccg tct gga      409
 Pro Asp Gly Ser Gln Gln Ser Pro Asp Gly Thr Gln Leu Pro Ser Gly
      80                  85                  90

 cac ccc ttg cct gcc aca agc cag ggc act gca agc aaa tgc cct ttc      457
 His Pro Leu Pro Ala Thr Ser Gln Gly Thr Ala Ser Lys Cys Pro Phe
  95                 100                 105                 110

 ctg gca gca cag atg aat cag aga ggc agc agt gtc ttc tgc aaa gcc      505
 Leu Ala Ala Gln Met Asn Gln Arg Gly Ser Ser Val Phe Cys Lys Ala
                 115                 120                 125

 agt ctt gag ctt cag gag gat gtg cag gaa atg aat gcc gtg agg aaa      553
 Ser Leu Glu Leu Gln Glu Asp Val Gln Glu Met Asn Ala Val Arg Lys
             130                 135                 140

 gag gtt gct gaa acc tca gca ggc ccc agt gtg gtt agt gtg aaa acc      601
 Glu Val Ala Glu Thr Ser Ala Gly Pro Ser Val Val Ser Val Lys Thr
         145                 150                 155

 gat gga ggg gat ccc agt gga ctg ctg aag aac ttc cag gac atc atg      649
 Asp Gly Gly Asp Pro Ser Gly Leu Leu Lys Asn Phe Gln Asp Ile Met
     160                 165                 170

 caa aag caa aga cca gaa aga gtg tct cat ctt ctt caa gat aac ttg      697
 Gln Lys Gln Arg Pro Glu Arg Val Ser His Leu Leu Gln Asp Asn Leu
 175                 180                 185                 190

 cca aaa tct gtt tcc act ttt cag tat gat cgt ttc ttt gag aaa aaa      745
 Pro Lys Ser Val Ser Thr Phe Gln Tyr Asp Arg Phe Phe Glu Lys Lys
                 195                 200                 205

 att gat gag aaa aag aat gac cac acc tat cga gtt ttt aaa act gtg      793
 Ile Asp Glu Lys Lys Asn Asp His Thr Tyr Arg Val Phe Lys Thr Val
             210                 215                 220

 aac cgg cga gca cac atc ttc ccc atg gca gat gac tat tca gac tcc      841
 Asn Arg Arg Ala His Ile Phe Pro Met Ala Asp Asp Tyr Ser Asp Ser
         225                 230                 235

 ctc atc acc aaa aag caa gtg tca gtc tgg tgc agt aat gac tac cta      889
 Leu Ile Thr Lys Lys Gln Val Ser Val Trp Cys Ser Asn Asp Tyr Leu
     240                 245                 250

 gga atg agt cgc cac cca cgg gtg tgt ggg gca gtt atg gac act ttg      937
 Gly Met Ser Arg His Pro Arg Val Cys Gly Ala Val Met Asp Thr Leu
 255                 260                 265                 270

 aaa caa cat ggt gct ggg gca ggt ggt act aga aat att tct gga act      985
 Lys Gln His Gly Ala Gly Ala Gly Gly Thr Arg Asn Ile Ser Gly Thr
                 275                 280                 285

 agt aaa ttc cat gtg gac tta gag cgg gag ctg gca gac ctc cat ggg     1033
 Ser Lys Phe His Val Asp Leu Glu Arg Glu Leu Ala Asp Leu His Gly
             290                 295                 300

 aaa gat gcc gca ctc ttg ttt tcc tcg tgc ttt gtg gcc aat gac tca     1081
 Lys Asp Ala Ala Leu Leu Phe Ser Ser Cys Phe Val Ala Asn Asp Ser
         305                 310                 315

 acc ctc ttc acc ctg gct aag atg atg cca ggc tgt gag att tac tct     1129
 Thr Leu Phe Thr Leu Ala Lys Met Met Pro Gly Cys Glu Ile Tyr Ser
     320                 325                 330

 gat tct ggg aac cat gcc tcc atg atc caa ggg att cga aac agc cga     1177
 Asp Ser Gly Asn His Ala Ser Met Ile Gln Gly Ile Arg Asn Ser Arg
 335                 340                 345                 350

 gtg cca aag tac atc ttc cgc cac aat gat gtc agc cac ctc aga gaa     1225
 Val Pro Lys Tyr Ile Phe Arg His Asn Asp Val Ser His Leu Arg Glu
                 355                 360                 365

 ctg ctg caa aga tct gac ccc tca gtc ccc aag att gtg gca ttt gaa     1273
 Leu Leu Gln Arg Ser Asp Pro Ser Val Pro Lys Ile Val Ala Phe Glu
             370                 375                 380

 act gtc cat tca atg gat ggg gcg gtg tgc cca ctg gaa gag ctg tgt     1321
 Thr Val His Ser Met Asp Gly Ala Val Cys Pro Leu Glu Glu Leu Cys
         385                 390                 395

 gat gtg gcc cat gag ttt gga gca atc acc ttc gtg gat gag gtc cac     1369
 Asp Val Ala His Glu Phe Gly Ala Ile Thr Phe Val Asp Glu Val His
     400                 405                 410

 gca gtg ggg ctt tat ggg gct cga ggc gga ggg att ggg gat cgg gat     1417
 Ala Val Gly Leu Tyr Gly Ala Arg Gly Gly Gly Ile Gly Asp Arg Asp
 415                 420                 425                 430

 gga gtc atg cca aaa atg gac atc att tct gga aca ctt ggc aaa gcc     1465
 Gly Val Met Pro Lys Met Asp Ile Ile Ser Gly Thr Leu Gly Lys Ala
                 435                 440                 445

 ttt ggt tgt gtt gga ggg tac atc gcc agc acg agt tct ctg att gac     1513
 Phe Gly Cys Val Gly Gly Tyr Ile Ala Ser Thr Ser Ser Leu Ile Asp
             450                 455                 460

 acc gta cgg tcc tat gct gct ggc ttc atc ttc acc acc tct ctg cca     1561
 Thr Val Arg Ser Tyr Ala Ala Gly Phe Ile Phe Thr Thr Ser Leu Pro
         465                 470                 475

 ccc atg ctg ctg gct gga gcc ctg gag tct gtg cgg atc ctg aag agc     1609
 Pro Met Leu Leu Ala Gly Ala Leu Glu Ser Val Arg Ile Leu Lys Ser
     480                 485                 490

 gct gag gga cgg gtg ctt cgc cgc cag cac cag cgc aac gtc aaa ctc     1657
 Ala Glu Gly Arg Val Leu Arg Arg Gln His Gln Arg Asn Val Lys Leu
 495                 500                 505                 510

 atg aga cag atg cta atg gat gcc ggc ctc cct gtt gtc cac tgc ccc     1705
 Met Arg Gln Met Leu Met Asp Ala Gly Leu Pro Val Val His Cys Pro
                 515                 520                 525

 agc cac atc atc cct gtg cgg gtt gca gat gct gct aaa aac aca gaa     1753
 Ser His Ile Ile Pro Val Arg Val Ala Asp Ala Ala Lys Asn Thr Glu
             530                 535                 540

 gtc tgt gat gaa cta atg agc aga cat aac atc tac gtg caa gca atc     1801
 Val Cys Asp Glu Leu Met Ser Arg His Asn Ile Tyr Val Gln Ala Ile
         545                 550                 555

 aat tac cct acg gtg ccc cgg gga gaa gag ctc cta cgg att gcc ccc     1849
 Asn Tyr Pro Thr Val Pro Arg Gly Glu Glu Leu Leu Arg Ile Ala Pro
     560                 565                 570

 acc cct cac cac aca ccc cag atg atg aac tac ttc ctt gag aat ctg     1897
 Thr Pro His His Thr Pro Gln Met Met Asn Tyr Phe Leu Glu Asn Leu
 575                 580                 585                 590

 cta gtc aca tgg aag caa gtg ggg ctg gaa ctg aag cct cat tcc tca     1945
 Leu Val Thr Trp Lys Gln Val Gly Leu Glu Leu Lys Pro His Ser Ser
                 595                 600                 605

 gct gag tgc aac ttc tgc agg agg cca ctg cat ttt gaa gtg atg agt     1993
 Ala Glu Cys Asn Phe Cys Arg Arg Pro Leu His Phe Glu Val Met Ser
             610                 615                 620

 gaa aga gag aag tcc tat ttc tca ggc ttg agc aag ttg gta tct gct     2041
 Glu Arg Glu Lys Ser Tyr Phe Ser Gly Leu Ser Lys Leu Val Ser Ala
         625                 630                 635

 cag gcc tga gcatgac ctcaattatt tcacttaacc ccaggccatt atcatatcca     2097
 Gln Ala 
     640

 gatggtcttc agagttgtct ttatatgtga attaagttat attaaatttt aatctatagt   2157

 aaaaacatag tcctggaaat aaaaaaaaaa aa                                 2189




      <210> 20
      <211> 1920
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (59)..(745)

      <400> 20
 ggcggttgtc tgtggccgga ggctgatcag tgttctagaa cagatcagac attttgta       58                                                                 
 atg atg cct gaa ata aac act aac cac ctc gac aag caa cag gtt caa      106
 Met Met Pro Glu Ile Asn Thr Asn His Leu Asp Lys Gln Gln Val Gln
   1               5                  10                  15

 ctc ctg gca gag atg tgt atc ctt att gat gaa aat gac aat aaa att      154
 Leu Leu Ala Glu Met Cys Ile Leu Ile Asp Glu Asn Asp Asn Lys Ile
              20                  25                  30

 gga gct gag acc aag aag aat tgt cac ctg aac gag aac att gag aaa      202
 Gly Ala Glu Thr Lys Lys Asn Cys His Leu Asn Glu Asn Ile Glu Lys
          35                  40                  45

 gga tta ttg cat cga gct ttt agt gtc ttc tta ttc aac acc gaa aat      250
 Gly Leu Leu His Arg Ala Phe Ser Val Phe Leu Phe Asn Thr Glu Asn
      50                  55                  60

 aag ctt ctg cta cag caa aga tca gat gct aag att acc ttt cca ggt      298
 Lys Leu Leu Leu Gln Gln Arg Ser Asp Ala Lys Ile Thr Phe Pro Gly
  65                  70                  75                  80

 tgt ttt acg aat acg tgt tgt agt cat cca tta agc aat cca gcc gag      346
 Cys Phe Thr Asn Thr Cys Cys Ser His Pro Leu Ser Asn Pro Ala Glu
                  85                  90                  95

 ctt gag gaa agt gac gcc ctt gga gtg agg cga gca gca cag aga cgg      394
 Leu Glu Glu Ser Asp Ala Leu Gly Val Arg Arg Ala Ala Gln Arg Arg
             100                 105                 110

 ctg aaa gct gag cta gga att ccc ttg gaa gag gtt cct cca gaa gaa      442
 Leu Lys Ala Glu Leu Gly Ile Pro Leu Glu Glu Val Pro Pro Glu Glu
         115                 120                 125

 att aat tat tta aca cga att cac tac aaa gct cag tct gat ggt atc      490
 Ile Asn Tyr Leu Thr Arg Ile His Tyr Lys Ala Gln Ser Asp Gly Ile
     130                 135                 140

 tgg ggt gaa cat gaa att gat tac att ttg ttg gtg agg aag aat gta      538
 Trp Gly Glu His Glu Ile Asp Tyr Ile Leu Leu Val Arg Lys Asn Val
 145                 150                 155                 160

 act ttg aat cca gat ccc aat gag att aaa agc tat tgt tat gtg tca      586
 Thr Leu Asn Pro Asp Pro Asn Glu Ile Lys Ser Tyr Cys Tyr Val Ser
                 165                 170                 175

 aag gaa gaa cta aaa gaa ctt ctg aaa aaa gca gcc agt ggt gaa att      634
 Lys Glu Glu Leu Lys Glu Leu Leu Lys Lys Ala Ala Ser Gly Glu Ile
             180                 185                 190

 aag ata acg cca tgg ttt aaa att att gca gcg act ttt ctc ttt aaa      682
 Lys Ile Thr Pro Trp Phe Lys Ile Ile Ala Ala Thr Phe Leu Phe Lys
         195                 200                 205

 tgg tgg gat aac tta aat cat ttg aat cag ttt gtt gac cat gag aaa      730
 Trp Trp Asp Asn Leu Asn His Leu Asn Gln Phe Val Asp His Glu Lys
     210                 215                 220

 ata tac aga atg tga atatgtaggt aaatgattac agaaaaattt atctgcttaa      785
 Ile Tyr Arg Met 
 225

 caaacttaga atgacttttt ccttttaaat ttagttctat cattaattta tcattaaatt    845

 tagttctatc atttggtact atcattaatg tattatatac actgatactt taaaacttgt    905

 gtggaaaaaa ctaacttata attttgtatc acacaccctg gatatgtgtt ctgtttctaa    965

 gcgacatttg tgagagatta ttgtaaaatg agagcgagca aataaaactt aatttaatct   1025

 ttgcagatac atacttatgg gaaatttgaa caaatgagtg aaactctgtg tttttagtag   1085

 gctgtgataa acatttccgg agcacttgca gaggacttgc tatttgccag gtgctttatg   1145

 tatcattaaa tttttctcat agttcagaaa aatgtgcaaa ggaaactatt gtctcgctcc   1205

 ttcaaaacag tcttaattaa ctttcatatt agcagattaa actagcagag caggttcaag   1265

 ggaaattaaa tgatatggac cctaatttgt atcattctga gttgattgtg tggtttattc   1325

 attctggaaa catgttgata cttacagtca gccactgctt ttgataagtg atattgatta   1385

 ggttgaatct tcttgtaaat agtatttacc agttagcaaa gtctgtgttt tcagaattac   1445

 agtgagcaca gaggtgttca taaaatggga attgagtccc actcggtaag agttgcttaa   1505

 acttgacact gttgacattt gggctggata aaacccctgt ggtggggtct gtgctgtgca   1565

 ttgcaggatg gtgagcagcg tccctctcat gtgacaccca cagttatgcc ggatgttgcc   1625

 agatgcccct aggggacaga gtcaaccccc aactgaggac cactgtccta cagagtcagg   1685

 aaatattgta gggagaaaaa aataacaaca acaaaggcct gtgttaatgt taaatagatg   1745

 agattatgga atgtgtatat taatgttaaa aattgtacct tgatcaatgt actttttata   1805

 aacttgccat agatatctca gatttgaaac ctcaagacag atttattatt cttaaatgct   1865

 gtatgataat gaagaaaaat aaaaatttat ttcttgcaaa gttaaaaaaa aaaaa        1920




      <210> 21
      <211> 1732
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (176)..(1648)

      <400> 21
 gaaagagccg gtgaaggggc agaacaggca ggttccctcg acccaggacc ccctgttccc     60

 aggctatggc ccccagtgcc ctgtagacct ggcaggcccc ccgtgcttgc gacccctatt    120

 tgggggtctg ggtggctact ggagggcctt gcagaggggc agagaaggca ggacc atg     178
                                                              Met
                                                                1

 aca tct agg gcc tct gaa ctt tct ccg ggg cgc agc gtg acg gct ggc      226
 Thr Ser Arg Ala Ser Glu Leu Ser Pro Gly Arg Ser Val Thr Ala Gly
               5                  10                  15

 atc atc att gtt gga gat gag atc ctt aag gga cac act cag gac acc      274
 Ile Ile Ile Val Gly Asp Glu Ile Leu Lys Gly His Thr Gln Asp Thr
          20                  25                  30

 aac acc ttc ttt ctg tgc cgg aca ctg cgc tcc cta ggg gtc cag gtt      322
 Asn Thr Phe Phe Leu Cys Arg Thr Leu Arg Ser Leu Gly Val Gln Val
      35                  40                  45

 tgc cga gtc tca gtt gta cct gat gag gta gcc acc att gca gct gag      370
 Cys Arg Val Ser Val Val Pro Asp Glu Val Ala Thr Ile Ala Ala Glu
  50                  55                  60                  65

 gtc act tct ttc tcc aac cgc ttc acc cat gtc ctc aca gca ggg ggc      418
 Val Thr Ser Phe Ser Asn Arg Phe Thr His Val Leu Thr Ala Gly Gly
                  70                  75                  80

 atc ggc ccc act cat gat gat gtg acc ttt gag gca gtg gca cag gcc      466
 Ile Gly Pro Thr His Asp Asp Val Thr Phe Glu Ala Val Ala Gln Ala
              85                  90                  95

 ttt gga gat gag ctg aag cca cac ccc aag ttg gaa gca gcc acc aaa      514
 Phe Gly Asp Glu Leu Lys Pro His Pro Lys Leu Glu Ala Ala Thr Lys
         100                 105                 110

 gcc cta gga ggg gaa ggc tgg gag aag cta tca ttg gtg ccc tcc tct      562
 Ala Leu Gly Gly Glu Gly Trp Glu Lys Leu Ser Leu Val Pro Ser Ser
     115                 120                 125

 gcc cgc ctg cat tat ggc aca gat cct tgc act ggt caa cct ttc aga      610
 Ala Arg Leu His Tyr Gly Thr Asp Pro Cys Thr Gly Gln Pro Phe Arg
 130                 135                 140                 145

 ttc cct ctg gtc tcc gtc cga aac gtc tac ctc ttc cca ggc att cca      658
 Phe Pro Leu Val Ser Val Arg Asn Val Tyr Leu Phe Pro Gly Ile Pro
                 150                 155                 160

 gag ctg ctg cgg cgg gtg ctg gag ggg atg aag gga cta ttc caa aac      706
 Glu Leu Leu Arg Arg Val Leu Glu Gly Met Lys Gly Leu Phe Gln Asn
             165                 170                 175

 cca gct gtt cag ttc cac tca aag gag cta tat gtg gct gct gat gaa      754
 Pro Ala Val Gln Phe His Ser Lys Glu Leu Tyr Val Ala Ala Asp Glu
         180                 185                 190

 gcc tcc atc gcc ccc att ctg gct gag gcc cag gcc cac ttt gga cgt      802
 Ala Ser Ile Ala Pro Ile Leu Ala Glu Ala Gln Ala His Phe Gly Arg
     195                 200                 205

 agg ctt ggc ctg ggt tcc tac cct gac tgg ggc agc aac tac tat cag      850
 Arg Leu Gly Leu Gly Ser Tyr Pro Asp Trp Gly Ser Asn Tyr Tyr Gln
 210                 215                 220                 225

 gtg aag ctg act cta gac tca gag gaa gaa gga ccc ctg gag gaa tgc      898
 Val Lys Leu Thr Leu Asp Ser Glu Glu Glu Gly Pro Leu Glu Glu Cys
                 230                 235                 240

 ttg gcc tac ctg act gcc cgt ttg ccc cag gga tcg ctg gtc ccc tac      946
 Leu Ala Tyr Leu Thr Ala Arg Leu Pro Gln Gly Ser Leu Val Pro Tyr
             245                 250                 255

 atg ccc aac gct gtg gag cag gcc agt gag gct gta tac aaa ctc gct      994
 Met Pro Asn Ala Val Glu Gln Ala Ser Glu Ala Val Tyr Lys Leu Ala
         260                 265                 270

 gaa tca ggg tct tct ttg ggg aaa aag gtg gca ggt gcc cta cag acc     1042
 Glu Ser Gly Ser Ser Leu Gly Lys Lys Val Ala Gly Ala Leu Gln Thr
     275                 280                 285

 att gag acc tcc ctg gct cag tac agc ctc acc cag ctc tgt gtg ggc     1090
 Ile Glu Thr Ser Leu Ala Gln Tyr Ser Leu Thr Gln Leu Cys Val Gly
 290                 295                 300                 305

 ttc aac ggg ggc aaa gac tgc act gcc ctc ctg cac ctc ttc cat gca     1138
 Phe Asn Gly Gly Lys Asp Cys Thr Ala Leu Leu His Leu Phe His Ala
                 310                 315                 320

 gct gtg cag agg aaa tta cct gat gtt cca aac ccc ctc cag atc ctg     1186
 Ala Val Gln Arg Lys Leu Pro Asp Val Pro Asn Pro Leu Gln Ile Leu
             325                 330                 335

 tat atc cgc agc atc tcc cct ttc cct gag ctg gaa cag ttt cta cag     1234
 Tyr Ile Arg Ser Ile Ser Pro Phe Pro Glu Leu Glu Gln Phe Leu Gln
         340                 345                 350

 gac act atc aag agg tat aat ctg cag atg ttg gaa gct gag ggc agc     1282
 Asp Thr Ile Lys Arg Tyr Asn Leu Gln Met Leu Glu Ala Glu Gly Ser
     355                 360                 365

 atg aag cag gcc ctg ggt gaa ctg cag gca cgg cac ccc cag ctg gag     1330
 Met Lys Gln Ala Leu Gly Glu Leu Gln Ala Arg His Pro Gln Leu Glu
 370                 375                 380                 385

 gct gtc ctt atg ggc acc cgc cgg act gac ccc tac tcc tgt agc ctc     1378
 Ala Val Leu Met Gly Thr Arg Arg Thr Asp Pro Tyr Ser Cys Ser Leu
                 390                 395                 400

 tgc cct ttc agc ccc act gac cca ggc tgg ccc gca ttc atg cgc atc     1426
 Cys Pro Phe Ser Pro Thr Asp Pro Gly Trp Pro Ala Phe Met Arg Ile
             405                 410                 415

 aac cca ctg ctg gac tgg acc tac aga gac atc tgg gat ttt ctg cgt     1474
 Asn Pro Leu Leu Asp Trp Thr Tyr Arg Asp Ile Trp Asp Phe Leu Arg
         420                 425                 430

 cag ctg ttt gtc cca tac tgt atc ctg tat gac cga gga tac aca tca     1522
 Gln Leu Phe Val Pro Tyr Cys Ile Leu Tyr Asp Arg Gly Tyr Thr Ser
     435                 440                 445

 ctg ggg agt cgg gag aat acc gtg cgg aac ccg gcc ctg aag tgc ctg     1570
 Leu Gly Ser Arg Glu Asn Thr Val Arg Asn Pro Ala Leu Lys Cys Leu
 450                 455                 460                 465

 agc cca gga gga cac ccc aca tac cgt cca gcc tat cta ctg gag aac     1618
 Ser Pro Gly Gly His Pro Thr Tyr Arg Pro Ala Tyr Leu Leu Glu Asn
                 470                 475                 480

 gaa gaa gag gag cgg aac tcc cgc aca tga c ctcccaccct aggagggagg     1669
 Glu Glu Glu Glu Arg Asn Ser Arg Thr 
             485                 490

 gaaggacacc gtcctagggt ataacctggc aataaaccgt gcctctcact gtgaaaaaaa   1729

 aaa                                                                 1732




      <210> 22
      <211> 1101
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (91)..(504)

      <400> 22
 aaggatcctt aattaaatta atcccccccc ccccgggtgc gacagcagct ggagggcaga     60

 ggaggcggcg cggggtgtcc tgtcctcgcc     atg agg ccg cag cag gcg ccg     111
                                      Met Arg Pro Gln Gln Ala Pro
                                        1               5

 gtg tcc gga aag gtg ttc att cag cga gac tac agc agt ggc aca cgc      159
 Val Ser Gly Lys Val Phe Ile Gln Arg Asp Tyr Ser Ser Gly Thr Arg
          10                  15                  20

 tgc cag ttc cag acc aag ttc cct gcg gag ctg gag aac cgg att gat      207
 Cys Gln Phe Gln Thr Lys Phe Pro Ala Glu Leu Glu Asn Arg Ile Asp
      25                  30                  35

 agg cag cag ttt gaa gaa aca gtt cga act cta aat aac ctt tat gca      255
 Arg Gln Gln Phe Glu Glu Thr Val Arg Thr Leu Asn Asn Leu Tyr Ala
  40                  45                  50                  55

 gaa gca gag aag ctc ggc ggc cag tca tat ctc gaa ggt tgt ttg gct      303
 Glu Ala Glu Lys Leu Gly Gly Gln Ser Tyr Leu Glu Gly Cys Leu Ala
                  60                  65                  70

 tgt tta aca gca tat acc atc ttc cta tgc atg gaa act cat tat gag      351
 Cys Leu Thr Ala Tyr Thr Ile Phe Leu Cys Met Glu Thr His Tyr Glu
              75                  80                  85

 aag gtt ctg aag aaa gtc tcc aaa tac att caa gag cag aat gag aag      399
 Lys Val Leu Lys Lys Val Ser Lys Tyr Ile Gln Glu Gln Asn Glu Lys
          90                  95                 100

 atc tat gct cca caa ggc ctc ctc ctg aca gac cct att gag cga gga      447
 Ile Tyr Ala Pro Gln Gly Leu Leu Leu Thr Asp Pro Ile Glu Arg Gly
     105                 110                 115

 ctg cga gtt att gaa att acc att tat gaa gac aga ggc atg agc agt      495
 Leu Arg Val Ile Glu Ile Thr Ile Tyr Glu Asp Arg Gly Met Ser Ser
 120                 125                 130                 135

 gga aga taa accgaag aattaaagat cccacttcca gccgggcccc tcatgtatcc      551
 Gly Arg 


 actggccgac cgcagagtgt ccctacctcc tctccagagc atcattcctt tctatctgct    611

 gccagagcca cggtgccatt tactccaagg actcactttc taaaattcca cacctggagt    671

 gacctctagt cgctcagcat ccactttgtg tctccaaatt gtgtaggact ctgtaatctt    731

 ttgattagtt tctgagaaaa cacaatgaag cacttcactt ttttttattc aaagccattt    791

 aataaaacac agttggtcag cccagtgcaa agcttgttat ctgccaccag tacataccat    851

 tggttctctt cattccttgg gccagcttct caggtggctt tagacctcaa caagccgtat    911

 cttcaccagt gttctatctt gttcccctaa attaataaaa tgtttttctc caggattttg    971

 gtgagggttg gctgtggctg tcgttttgca cctcccagat ttcaaagaat taccggtttt   1031

 accatgactc aaatcttaag atctgtttct actattcagt tcctcaaact gaagcttatt   1091

 gaaaaaaaaa                                                          1101




      <210> 23
      <211> 852
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (377)..(592)

      <220>
      <221> misc_feature
      <222> (1)...(852)
      <223> n = a,t,c or g

      <400> 23
 agtgcggagg aattccgaga atctgcatct ttttgtaaca gggagcctgt cacggagggg     60

 cattattgcc tgtctgttgg cacatgactg gggaaaagga ggattcagag aatctggatg    120

 aattcatttt atgaacttct ggtgacaggc cagcaaaagg atgaagagaa aaatcttcaa    180

 gctttcagaa gccaaaggaa caaattatta aggaaaagag tcacactggc accagatttc    240

 ctatttacaa caccaagaag ctagaagatg gtggaatttc atctacagac cacggggata    300

 aaaggaatgc agctcaagca tcctgtaccc aggtttcaag tgccccattt gctccaagtc    360

 tgtggcttct gacgag    atg gaa atg cac ttt ata atg tgt ttg agc aaa     409
                      Met Glu Met His Phe Ile Met Cys Leu Ser Lys
                        1               5                  10

 cct cgc ctc tcc tac aac gat gat gtg ctg act aaa gac gcg ggt gag      457
 Pro Arg Leu Ser Tyr Asn Asp Asp Val Leu Thr Lys Asp Ala Gly Glu
              15                  20                  25

 tgt gtg atc tgc ctg gag gag ctg ctg cag ggg gac acg ata gcc agg      505
 Cys Val Ile Cys Leu Glu Glu Leu Leu Gln Gly Asp Thr Ile Ala Arg
          30                  35                  40

 ctg ccc tgc ctg tgc atc tat cac aaa agc tgc ata gac tcg tgg ttt      553
 Leu Pro Cys Leu Cys Ile Tyr His Lys Ser Cys Ile Asp Ser Trp Phe
      45                  50                  55

 gaa gtg aac aga tct tgt ccg gaa cac cct gcg gac tga cctgcgggct       602
 Glu Val Asn Arg Ser Cys Pro Glu His Pro Ala Asp 
  60                  65                  70

 tgcttgctga ctcctctcaa aggcccgcct gatgtgctgg accatccccc tgctgccacg    662

 gcccctggct ccgcagtcac cctccatcag atgcttccag aagcacctac tctgtgcaag    722

 ggcattcaca acaggccagt gggcaaacgt gagccagggc cagcggagaa acactaaaga    782

 agactcggtg gttcagagcc tgggtctcag cgcgggaccc gtctgtngtg aagaccttgg    842

 ggctgttgtg                                                           852




      <210> 24
      <211> 2150
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (173)..(1321)

      <400> 24
 cgcttgggta gaggaagccg tgaggccgga gcttaggtcg ggaagggatg gatcgctgag     60

 ccgatagcgt ccgctaggct gtctgcctcg gtacctgtta ctgctgctac ttcctcgttt    120

 gacaccttcc tggaatctct cttgattttt gaggaaatac ctagtaacaa ac    atg     175
                                                              Met
                                                                1

 act gag ttc tgg ctt ata tct gct cct ggg gag aaa acc tgt cag caa      223
 Thr Glu Phe Trp Leu Ile Ser Ala Pro Gly Glu Lys Thr Cys Gln Gln
               5                  10                  15

 aca tgg gag aaa ttg cat gcg gca act tca aag aac aat aat ctt gct      271
 Thr Trp Glu Lys Leu His Ala Ala Thr Ser Lys Asn Asn Asn Leu Ala
          20                  25                  30

 gtc act tcc aag ttc aat att cct gac tta aag gtt ggc acg ttg gat      319
 Val Thr Ser Lys Phe Asn Ile Pro Asp Leu Lys Val Gly Thr Leu Asp
      35                  40                  45

 gtc ttg gtt ggc ttg tca gat gaa ctg gct aaa ctg gat gca ttt gta      367
 Val Leu Val Gly Leu Ser Asp Glu Leu Ala Lys Leu Asp Ala Phe Val
  50                  55                  60                  65

 gaa gga gtg gtt aag aaa gta gct caa tac atg gct gat gta ttg gaa      415
 Glu Gly Val Val Lys Lys Val Ala Gln Tyr Met Ala Asp Val Leu Glu
                  70                  75                  80

 gat agc aaa gac aaa gtt caa gag aat ctg ttg gct aat gga gtg gac      463
 Asp Ser Lys Asp Lys Val Gln Glu Asn Leu Leu Ala Asn Gly Val Asp
              85                  90                  95

 ttg gtt act tat ata aca agg ttc cag tgg gac atg gcc aaa tat cca      511
 Leu Val Thr Tyr Ile Thr Arg Phe Gln Trp Asp Met Ala Lys Tyr Pro
         100                 105                 110

 atc aag cag tcc ctg aaa aat att tct gaa ata att gcc aag gga gta      559
 Ile Lys Gln Ser Leu Lys Asn Ile Ser Glu Ile Ile Ala Lys Gly Val
     115                 120                 125

 act cag att gat aat gac ctg aaa tct cga gca tct gca tac aat aac      607
 Thr Gln Ile Asp Asn Asp Leu Lys Ser Arg Ala Ser Ala Tyr Asn Asn
 130                 135                 140                 145

 ctg aaa gga aat ctt cag aat ttg gaa cga aag aat gca gga agt ttg      655
 Leu Lys Gly Asn Leu Gln Asn Leu Glu Arg Lys Asn Ala Gly Ser Leu
                 150                 155                 160

 cta act aga agt cta gca gaa att gtg aag aag gat gac ttt gtt ctt      703
 Leu Thr Arg Ser Leu Ala Glu Ile Val Lys Lys Asp Asp Phe Val Leu
             165                 170                 175

 gat tca gag tat ctc gtc aca tta ctg gta gta gtt ccc aag tta aac      751
 Asp Ser Glu Tyr Leu Val Thr Leu Leu Val Val Val Pro Lys Leu Asn
         180                 185                 190

 cac aac gac tgg att aag cag tat gaa aca cta gcc gaa atg gta gtt      799
 His Asn Asp Trp Ile Lys Gln Tyr Glu Thr Leu Ala Glu Met Val Val
     195                 200                 205

 cca agg tct agc aat gtt ctt tca gag gac caa gac agt tac ctg tgt      847
 Pro Arg Ser Ser Asn Val Leu Ser Glu Asp Gln Asp Ser Tyr Leu Cys
 210                 215                 220                 225

 aat gtc acc ttg ttt agg aag gca gtt gat gac ttc aga cac aaa gcc      895
 Asn Val Thr Leu Phe Arg Lys Ala Val Asp Asp Phe Arg His Lys Ala
                 230                 235                 240

 aga gaa aac aaa ttc att gtt cgt gac ttc cag tat aat gaa gag gag      943
 Arg Glu Asn Lys Phe Ile Val Arg Asp Phe Gln Tyr Asn Glu Glu Glu
             245                 250                 255

 atg aaa gca gat aaa gaa gaa atg aac agg ctt tct act gat aag aaa      991
 Met Lys Ala Asp Lys Glu Glu Met Asn Arg Leu Ser Thr Asp Lys Lys
         260                 265                 270

 aaa caa ttt gga cca ctt gta cgg tgg ctg aaa gtg aat ttt agt gaa     1039
 Lys Gln Phe Gly Pro Leu Val Arg Trp Leu Lys Val Asn Phe Ser Glu
     275                 280                 285

 gca ttt att gca tgg att cac gtg aaa gca tta cgg gtt ttc gtt gag     1087
 Ala Phe Ile Ala Trp Ile His Val Lys Ala Leu Arg Val Phe Val Glu
 290                 295                 300                 305

 tct gtt tta agg tat ggc ttg cca gtg aac ttc caa gca atg cta ctt     1135
 Ser Val Leu Arg Tyr Gly Leu Pro Val Asn Phe Gln Ala Met Leu Leu
                 310                 315                 320

 cag ccc aat aag aaa act ttg aag aaa ctg aga gaa gta tta cat gaa     1183
 Gln Pro Asn Lys Lys Thr Leu Lys Lys Leu Arg Glu Val Leu His Glu
             325                 330                 335

 ttg tat aaa cat cta gac agc agt gca gca gct att att gat gct cct     1231
 Leu Tyr Lys His Leu Asp Ser Ser Ala Ala Ala Ile Ile Asp Ala Pro
         340                 345                 350

 atg gat att cca ggt tta aac ctg agt caa caa gaa tac tac ccc tat     1279
 Met Asp Ile Pro Gly Leu Asn Leu Ser Gln Gln Glu Tyr Tyr Pro Tyr
     355                 360                 365

 gtg tac tac aag att gat tgc aac ttg ctg gaa ttc aag tga aaatggg     1328
 Val Tyr Tyr Lys Ile Asp Cys Asn Leu Leu Glu Phe Lys 
 370                 375                 380

 ctcctccccc gacaatcctg tccttgtgtt tgtgtgtgct aacagaaata agttgcagta   1388

 tggtcgtact tttaactcta gtatcctttg cttgcttctt accccctttc ctaggtgaat   1448

 tctcccacag tggtctgtat ctcaacattt tctttttaaa ggaaaaaata tatatatata   1508

 gtttcttttt attgatcagg tctgtaaatg tgtactaaaa aaatcagagt ttatttataa   1568

 acagaatagt ttatttaaag agaaggtctc ttccttattg atatcatggt atgcattaat   1628

 tccatttgtt actattgtgc acaaaagccc tgttcacagg ggaatggtgt aaacatttat   1688

 actgttttgt tcactgtatt tagtagacat aactgttgaa tagttactga atcatgatgt   1748

 aaagaatatg tgaccatctt caggtatggg atttctgaac gtttcaaatt tcaatcaatg   1808

 agcactgtca acacccacag gagagaataa aattacctgt gcaaaggtgt attgtggtgt   1868

 gtgtaactta agattacagt tctgtttgag agttaaatga tgtcatagct cacttgctat   1928

 gctgcttcca ggattttgtt atatgctgag gtgtaaccat ttgtgttgtc tgactttcgt   1988

 atgatttaat tgagccaaat ttgggtcaga acacaaattt gaagatgact tttcagtata   2048

 tgatgggtat ttacatttga acactagaat tttaggtctc tcaaataatt aagaatagag   2108

 ccagttttga ataaagtcta gcagaactat gaaaaaaaaa aa                      2150




      <210> 25
      <211> 1588
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (104)..(694)

      <400> 25
 ggcttagttg ccggagctga acggcgcgga gctggtctga ggcgagccga gccgagcgag     60

 cgcggcggtg gggccgagag gacgcgcagg tggcggcgtt gcc  atg tcg cac ggt     115
                                                  Met Ser His Gly
                                                    1

 cac agc cac ggc ggg ggt ggc tgc cgc tgc gcc gcc gaa cgg gag gag      163
 His Ser His Gly Gly Gly Gly Cys Arg Cys Ala Ala Glu Arg Glu Glu
   5                  10                  15                  20

 ccg ccc gag cag cgc ggc ctg gcc tac ggc ctg tac ctg cgc atc gac      211
 Pro Pro Glu Gln Arg Gly Leu Ala Tyr Gly Leu Tyr Leu Arg Ile Asp
                  25                  30                  35

 ctg gag cgg ctg caa tgc ctt aac gag agc cgc gag ggc agc ggc cgc      259
 Leu Glu Arg Leu Gln Cys Leu Asn Glu Ser Arg Glu Gly Ser Gly Arg
              40                  45                  50

 ggc gtc ttc aag ccg tgg gag gag cgg acc gac cgc tca aga ttt acg      307
 Gly Val Phe Lys Pro Trp Glu Glu Arg Thr Asp Arg Ser Arg Phe Thr
          55                  60                  65

 ggc aat gtc aag ctc aaa ggc atc att ata atg gga gag gat gat gac      355
 Gly Asn Val Lys Leu Lys Gly Ile Ile Ile Met Gly Glu Asp Asp Asp
      70                  75                  80

 tca cac ccc tct gag atg aga ctg tac aag aat att cca cag atg tcc      403
 Ser His Pro Ser Glu Met Arg Leu Tyr Lys Asn Ile Pro Gln Met Ser
  85                  90                  95                 100

 ttt gat gat aca gaa agg gag cca gat cag acc ttt agt ctg aac cgg      451
 Phe Asp Asp Thr Glu Arg Glu Pro Asp Gln Thr Phe Ser Leu Asn Arg
                 105                 110                 115

 gat ctt aca gga gaa tta gag tat gct aca aaa att tct cgt ttt tca      499
 Asp Leu Thr Gly Glu Leu Glu Tyr Ala Thr Lys Ile Ser Arg Phe Ser
             120                 125                 130

 aat gtc tat cat ctc tca att cat att tca aaa aac ttc gga gca gat      547
 Asn Val Tyr His Leu Ser Ile His Ile Ser Lys Asn Phe Gly Ala Asp
         135                 140                 145

 acg aca aag gtc ttt tat att ggc ctg aga gga gag tgg act gag ctt      595
 Thr Thr Lys Val Phe Tyr Ile Gly Leu Arg Gly Glu Trp Thr Glu Leu
     150                 155                 160

 cgc cga cac gag gtg acc atc tgc aat tac gaa gca tct gcc aac cca      643
 Arg Arg His Glu Val Thr Ile Cys Asn Tyr Glu Ala Ser Ala Asn Pro
 165                 170                 175                 180

 gca gac cat agg gtc cat cag gtt acc cca cag aca cac ttt att tcc      691
 Ala Asp His Arg Val His Gln Val Thr Pro Gln Thr His Phe Ile Ser
                 185                 190                 195

 taa gggc tggccaaggc tcccatagag gcgctgtgtc agtgaagatg tacgactacc      748
 


 tgttgggaag gacaaaggga tgaggctcca gagagagttg gctgccacag cctctgccaa    808

 gctttgtctt tggggcttgc tgcagaaacc tggcctacgg aagatacgac accactggga    868

 gggttgtgta ggtgccaggg gaccatcgtg gttctctagg gcgctgtgga aattgggtct    928

 tgggctgggt ggcatctggc agtcatgggt aacacttgct tttccagtta atgtggccat    988

 gtgattccaa gtgtcatgtt gctttgtggc aagattgttg tgtgacttgt ttttttgttt   1048

 ttgtttttgt ttttttaaag gaaactattt gtgggctata ggaaactttc tgatgcctcc   1108

 ggattgtgtt agtagtagcc atcaggaggg tctccaacta aaacacttgt tcctgcttgc   1168

 tcctttcccc tctcattgtt cagcattctt gtcaagttgc ccagcttgga gttgtctgtc   1228

 acgcacatgt gtcctgtggt tatagctaga aggacaggag tctcctgctg atgcgtgata   1288

 gcttaagctt ggggagaagg tcttttccac tgcctagcta agcagtctgg ggagagcatg   1348

 gggatcattt ctatgtgtgt gggtaatctg gtcagtaaga ttgagactta gttaagattc   1408

 cccttggaaa ttccttaatg tttattagct tctaactagt gttgtaagtc cgatgccaga   1468

 atttggagat ttgagttctt cttttcatgg cttttattca ctgtgactaa taagcttcct   1528

 aataaatcct tgccagactt aaaaaaaaaa aaaaaaaaaa aattggcggc cgcaagctta   1588




      <210> 26
      <211> 1846
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (630)..(1649)

      <400> 26
 aaggatgagg aaaggatatc ccagagtgcc agggcgcgca aaccaaactt cacactctag     60

 gaagacagag gccagaggaa ccaggagggc ttcctggagg aggtggcatt tactctgggc    120

 ctaagagatc acaggaaaat ggaggccagc attctaggcc tggggaagag tttgggcaaa    180

 ggcttggcag taagagaata aaggtggggc ttgatgggcc agaggataag tgactcctca    240

 aggtcacaag acaccctgat ggctgggacc ccatctctga tggagcaagg cttctgatac    300

 ccaactgagg cttggcgcca aggactgaca tcaaggaagt ggattcctgc aaacctggca    360

 cccgagggtc cacttcctca atttctgtgc agctgggagg tgaggtaaga ggaagtgtgg    420

 gccacaggct aggcccagag agcctggagg aggagcctct gccagactgg agagaagcag    480

 gcctgagcct ccccaaaggc agctcctggg gactcccagg accacaggct gagacgagac    540

 gcagggtggc tggaggaagt gagaggtgaa ctcagcctgg gactggctgg gcgagactct    600

 ccacctgctc cctgggacca tcgcccacc  atg gct gtg gcc cag cag ctg cgg     653
                                  Met Ala Val Ala Gln Gln Leu Arg
                                    1               5

 gcc gag agt gac ttt gaa cag ctt ccg gat gat gtt gcc atc tcg gcc      701
 Ala Glu Ser Asp Phe Glu Gln Leu Pro Asp Asp Val Ala Ile Ser Ala
      10                  15                  20

 aac att gct gac atc gag gag aag aga ggc ttc acc agc cac ttt gtt      749
 Asn Ile Ala Asp Ile Glu Glu Lys Arg Gly Phe Thr Ser His Phe Val
  25                  30                  35                  40

 ttc gtc atc gag gtg aag aca aaa gga gga tcc aag tac ctc atc tac      797
 Phe Val Ile Glu Val Lys Thr Lys Gly Gly Ser Lys Tyr Leu Ile Tyr
                  45                  50                  55

 cgc cgc tac cgc cag ttc cat gct ttg cag agc aag ctg gag gag cgc      845
 Arg Arg Tyr Arg Gln Phe His Ala Leu Gln Ser Lys Leu Glu Glu Arg
              60                  65                  70

 ttc ggg cca gac agc aag agc agt gcc ctg gcc tgt acc ctg ccc aca      893
 Phe Gly Pro Asp Ser Lys Ser Ser Ala Leu Ala Cys Thr Leu Pro Thr
          75                  80                  85

 ctc cca gcc aaa gtc tac gtg ggt gtg aaa cag gag atc gcc gag atg      941
 Leu Pro Ala Lys Val Tyr Val Gly Val Lys Gln Glu Ile Ala Glu Met
      90                  95                 100

 cgg ata cct gcc ctc aac gcc tac atg aag agc ctg ctc agc ctg ccg      989
 Arg Ile Pro Ala Leu Asn Ala Tyr Met Lys Ser Leu Leu Ser Leu Pro
 105                 110                 115                 120

 gtc tgg gtg ctg atg gat gag gac gtc cgg atc ttc ttt tac cag tcg     1037
 Val Trp Val Leu Met Asp Glu Asp Val Arg Ile Phe Phe Tyr Gln Ser
                 125                 130                 135

 ccc tat gac tca gag cag gtg ccc cag gca ctc cgc cgg ctc cgc ccg     1085
 Pro Tyr Asp Ser Glu Gln Val Pro Gln Ala Leu Arg Arg Leu Arg Pro
             140                 145                 150

 cgc acc cgg aaa gtc aag agc gtg tcc cca cag ggc aac agc gtt gac     1133
 Arg Thr Arg Lys Val Lys Ser Val Ser Pro Gln Gly Asn Ser Val Asp
         155                 160                 165

 cgc atg gca gct ccg aga gca gag gct cta ttt gac ttc act gga aac     1181
 Arg Met Ala Ala Pro Arg Ala Glu Ala Leu Phe Asp Phe Thr Gly Asn
     170                 175                 180

 agc aaa ctg gag ctg aat ttc aaa gct gga gat gtg atc ttc ctc ctc     1229
 Ser Lys Leu Glu Leu Asn Phe Lys Ala Gly Asp Val Ile Phe Leu Leu
 185                 190                 195                 200

 agt cgg atc aac aaa gac tgg ctg gag ggc act gtc cgg gga gcc acg     1277
 Ser Arg Ile Asn Lys Asp Trp Leu Glu Gly Thr Val Arg Gly Ala Thr
                 205                 210                 215

 ggc atc ttc cct ctc tcc ttc gtg aag atc ctc aaa gac ttc cct gag     1325
 Gly Ile Phe Pro Leu Ser Phe Val Lys Ile Leu Lys Asp Phe Pro Glu
             220                 225                 230

 gag gac gac ccc acc aac tgg ctg cgt tgc tac tac tac gaa gac acc     1373
 Glu Asp Asp Pro Thr Asn Trp Leu Arg Cys Tyr Tyr Tyr Glu Asp Thr
         235                 240                 245

 atc agc acc atc aag gac atc gcg gtg gag gaa gat ctc agc agc act     1421
 Ile Ser Thr Ile Lys Asp Ile Ala Val Glu Glu Asp Leu Ser Ser Thr
     250                 255                 260

 ccc cta ttg aaa gac ctg ctg gag ctc aca agg cgg gag ttc cag aga     1469
 Pro Leu Leu Lys Asp Leu Leu Glu Leu Thr Arg Arg Glu Phe Gln Arg
 265                 270                 275                 280

 gag gac ata gct ctg aat tac cgg gac gct gag ggg gat ctg gtt cgg     1517
 Glu Asp Ile Ala Leu Asn Tyr Arg Asp Ala Glu Gly Asp Leu Val Arg
                 285                 290                 295

 ctg ctg tcg gat gag gac gta gcg ctc atg gtg cgg cag gct cgt ggc     1565
 Leu Leu Ser Asp Glu Asp Val Ala Leu Met Val Arg Gln Ala Arg Gly
             300                 305                 310

 ctc ccc tcc cag aag cgc ctc ttc ccc tgg aag ctg cac atc acg cag     1613
 Leu Pro Ser Gln Lys Arg Leu Phe Pro Trp Lys Leu His Ile Thr Gln
         315                 320                 325

 aag gac aac tac agg gtc tac aac acg atg cca tga gctg acggtgtccc     1663
 Lys Asp Asn Tyr Arg Val Tyr Asn Thr Met Pro 
     330                 335

 tggagcagtg aggggacacc agcaaaaacc ttcagctctc agaggagatt gggaccagga   1723

 aaacctggga ggatgggcag acttcctgtc tttgaggcta atggacccgt ggggcttgta   1783

 atctgtctct ttctactatt tacatctgat ttaaataaac cattccatct gaaaaaaaaa   1843

 aaa                                                                 1846




      <210> 27
      <211> 1807
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (630)..(1610)

      <400> 27
 aaggatgagg aaaggatatc ccagagtgcc agggcgcgca aaccaaactt cacactctag     60

 gaagacagag gccagaggaa ccaggagggc ttcctggagg aggtggcatt tactctgggc    120

 ctaagagatc acaggaaaat ggaggccagc attctaggcc tggggaagag tttgggcaaa    180

 ggcttggcag taagagaata aaggtggggc ttgatgggcc agaggataag tgactcctca    240

 aggtcacaag acaccctgat ggctgggacc ccatctctga tggagcaagg cttctgatac    300

 ccaactgagg cttggcgcca aggactgaca tcaaggaagt ggattcctgc aaacctggca    360

 cccgagggtc cacttcctca atttctgtgc agctgggagg tgaggtaaga ggaagtgtgg    420

 gccacaggct aggcccagag agcctggagg aggagcctct gccagactgg agagaagcag    480

 gcctgagcct ccccaaaggc agctcctggg gactcccagg accacaggct gagacgagac    540

 gcagggtggc tggaggaagt gagaggtgaa ctcagcctgg gactggctgg gcgagactct    600

 ccacctgctc cctgggacca tcgcccacc  atg gct gtg gcc cag cag ctg cgg     653
                                  Met Ala Val Ala Gln Gln Leu Arg
                                    1               5

 gcc gag agt gac ttt gaa cag ctt ccg gat gat gtt gcc atc tcg gcc      701
 Ala Glu Ser Asp Phe Glu Gln Leu Pro Asp Asp Val Ala Ile Ser Ala
      10                  15                  20

 aac att gct gac atc gag gag aag aga ggc ttc acc agc cac ttt gtt      749
 Asn Ile Ala Asp Ile Glu Glu Lys Arg Gly Phe Thr Ser His Phe Val
  25                  30                  35                  40

 ttc gtc atc gag gtg aag aca aaa gga gga tcc aag tac ctc atc tac      797
 Phe Val Ile Glu Val Lys Thr Lys Gly Gly Ser Lys Tyr Leu Ile Tyr
                  45                  50                  55

 cgc cgc tac cgc cag ttc cat gct ttg cag agc aag ctg gag gag cgc      845
 Arg Arg Tyr Arg Gln Phe His Ala Leu Gln Ser Lys Leu Glu Glu Arg
              60                  65                  70

 ttc ggg cca gac agc aag agc agt gcc ctg gcc tgt acc ctg ccc aca      893
 Phe Gly Pro Asp Ser Lys Ser Ser Ala Leu Ala Cys Thr Leu Pro Thr
          75                  80                  85

 ctc cca gcc aaa gtc tac gtg ggt gtg aaa cag gag atc gcc gag atg      941
 Leu Pro Ala Lys Val Tyr Val Gly Val Lys Gln Glu Ile Ala Glu Met
      90                  95                 100

 cgg ata cct gcc ctc aac gcc tac atg aag agc ctg ctc agc ctg ccg      989
 Arg Ile Pro Ala Leu Asn Ala Tyr Met Lys Ser Leu Leu Ser Leu Pro
 105                 110                 115                 120

 gtc tgg gtg ctg atg gat gag gac gtc cgg atc ttc ttt tac cag tcg     1037
 Val Trp Val Leu Met Asp Glu Asp Val Arg Ile Phe Phe Tyr Gln Ser
                 125                 130                 135

 ccc tat gac tca gag cag gtg ccc cag gca ctc cgc cgg ctc cgc ccg     1085
 Pro Tyr Asp Ser Glu Gln Val Pro Gln Ala Leu Arg Arg Leu Arg Pro
             140                 145                 150

 cgc acc cgg aaa gtc aag agc gtg tcc cca cag ggc aac agc gtt gac     1133
 Arg Thr Arg Lys Val Lys Ser Val Ser Pro Gln Gly Asn Ser Val Asp
         155                 160                 165

 cgc atg gca gct ccg aga gca gag gct cta ttt gac ttc act gga aac     1181
 Arg Met Ala Ala Pro Arg Ala Glu Ala Leu Phe Asp Phe Thr Gly Asn
     170                 175                 180

 agc aaa ctg gag ctg aat ttc aaa gct gga gat gtg atc ttc ctc ctc     1229
 Ser Lys Leu Glu Leu Asn Phe Lys Ala Gly Asp Val Ile Phe Leu Leu
 185                 190                 195                 200

 agt cgg atc aac aaa gac tgg ctg gag ggc act gtc cgg gga gcc acg     1277
 Ser Arg Ile Asn Lys Asp Trp Leu Glu Gly Thr Val Arg Gly Ala Thr
                 205                 210                 215

 ggc atc ttc cct ctc tcc ttc gtg aag atc ctc aaa gac ttc cct gag     1325
 Gly Ile Phe Pro Leu Ser Phe Val Lys Ile Leu Lys Asp Phe Pro Glu
             220                 225                 230

 gag gac gac ccc acc aac tgg ctg cgt tgc tac tac tac gaa gac acc     1373
 Glu Asp Asp Pro Thr Asn Trp Leu Arg Cys Tyr Tyr Tyr Glu Asp Thr
         235                 240                 245

 atc agc act ccc cta ttg aaa gac ctg ctg gag ctc aca agg cgg gag     1421
 Ile Ser Thr Pro Leu Leu Lys Asp Leu Leu Glu Leu Thr Arg Arg Glu
     250                 255                 260

 ttc cag aga gag gac ata gct ctg aat tac cgg gac gct gag ggg gat     1469
 Phe Gln Arg Glu Asp Ile Ala Leu Asn Tyr Arg Asp Ala Glu Gly Asp
 265                 270                 275                 280

 ctg gtt cgg ctg ctg tcg gat gag gac gta gcg ctc atg gtg cgg cag     1517
 Leu Val Arg Leu Leu Ser Asp Glu Asp Val Ala Leu Met Val Arg Gln
                 285                 290                 295

 gct cgt ggc ctc ccc tcc cag aag cgc ctc ttc ccc tgg aag ctg cac     1565
 Ala Arg Gly Leu Pro Ser Gln Lys Arg Leu Phe Pro Trp Lys Leu His
             300                 305                 310

 atc acg cag aag gac aac tac agg gtc tac aac acg atg cca tga gct     1613
 Ile Thr Gln Lys Asp Asn Tyr Arg Val Tyr Asn Thr Met Pro 
         315                 320                 325

 gacggtgtcc ctggagcagt gaggggacac cagcaaaaac cttcagctct cagaggagat   1673

 tgggaccagg aaaacctggg aggatgggca gacttcctgt ctttgaggct aatggacccg   1733

 tggggcttgt aatctgtctc tttctactat ttacatctga tttaaataaa ccattccatc   1793

 tgaaaaaaaa aaaa                                                     1807




      <210> 28
      <211> 680
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (221)..(478)

      <400> 28
 ctgggttagg tgccgctgtt gctgctcgtg ttgaatctag aaccgtagcc agacatggga     60

 ctggaggacg agcaaaagat gcttaccgaa tccggagatc ctgaggagga ggaagaggga    120

 gaggaggaat tagtgatagg actgaggctt tcagtgcata ctggcaacct tggaaggcag    180

 gaatgtgaaa cttttcccta ctacttagca tcagaattga  atg gga gac cgc att     235
                                              Met Gly Asp Arg Ile
                                                1               5

 ctg cca ttt ctg gcg gca gtg tgg ctc tgc cag ctg gcc ttc tgc acg      283
 Leu Pro Phe Leu Ala Ala Val Trp Leu Cys Gln Leu Ala Phe Cys Thr
                  10                  15                  20

 gat ccc cta aca aca gtg aga gag caa tgc gag cag ttg gag aaa tgt      331
 Asp Pro Leu Thr Thr Val Arg Glu Gln Cys Glu Gln Leu Glu Lys Cys
              25                  30                  35

 gta aag gcc cgg gag cgg cta gag ctc tgt gat gag cgt gta tcc tct      379
 Val Lys Ala Arg Glu Arg Leu Glu Leu Cys Asp Glu Arg Val Ser Ser
          40                  45                  50

 cga tca cat aca gaa gag gat tgc acg gag gag ctc ttt gac ttc ttg      427
 Arg Ser His Thr Glu Glu Asp Cys Thr Glu Glu Leu Phe Asp Phe Leu
      55                  60                  65

 cat gcg agg gac cat tgc gtg gcc cac aaa ctc ttt aac aac ttg aaa      475
 His Ala Arg Asp His Cys Val Ala His Lys Leu Phe Asn Asn Leu Lys
  70                  75                  80                  85

 taa atgt gtggacttaa ttcaccccag tcttcatcat ctgggcatca gaatatttcc      532
 


 ttatggtttt ggatgtacca tttgtttctt atttgtgtaa ctgtaagttc acatgaacct    592

 catgggtttg gcttaggctg gtagcttcta tgtaattcgc aatgattcca tctaaataaa    652

 agttctatga tctgcaaaaa aaaaaaaa                                       680




      <210> 29
      <211> 1792
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (438)..(713)

      <400> 29
 tgcttgattt tttcatgttc ttctacctgc tgatgcaaca ttccaacctc cttatgtgtc     60

 acatccaact gactcgtaag actcttaagt tcctgttcac ggattttcaa gcaagtttct    120

 agagcatgtg tacgtccttc ccattcagat tttttatgag ccaccattat gtcaatctgt    180

 ttcatgagct cctgtagttc tgcttcacaa gatgtcaaaa atcccccacc atgccctcga    240

 ttttgtattc cttctaacaa agcctccatc accaaatccc ctttgttttg gcaaccacat    300

 ccgggaatcc gaggaaagcg agtgcagaca cgtgatgcgg gggagggcgg ggcgtggcag    360

 gagcaagcgt ctgccgcggt ggccgggtgc cggtaagggt ttccagcgcc cccggcctag    420

 gttttggagg cgcggga   atg cgt tcg ttg ctc agt gtc gga ctt ccc cct     470
                      Met Arg Ser Leu Leu Ser Val Gly Leu Pro Pro
                        1               5                  10

 att ccc atc ggc cga ggc tgt cac ttt acg ctc ata acc gtt ttt ctt      518
 Ile Pro Ile Gly Arg Gly Cys His Phe Thr Leu Ile Thr Val Phe Leu
              15                  20                  25

 tac tgc act cgt gtc ggg agg aaa ggg act tgc gtg gca ccc cca gac      566
 Tyr Cys Thr Arg Val Gly Arg Lys Gly Thr Cys Val Ala Pro Pro Asp
          30                  35                  40

 ctc ccc gtc tcc gct tcc acg ttt ggt aca tcc tgc ctg agg cag gaa      614
 Leu Pro Val Ser Ala Ser Thr Phe Gly Thr Ser Cys Leu Arg Gln Glu
      45                  50                  55

 gcc gca gct gag gga cgg cct gtc gta cga ttt gac aag atc aaa gct      662
 Ala Ala Ala Glu Gly Arg Pro Val Val Arg Phe Asp Lys Ile Lys Ala
  60                  65                  70                  75

 gca gga aaa tgg aca gtg agg ttc aga gag atg gaa gga tct tgg att      710
 Ala Gly Lys Trp Thr Val Arg Phe Arg Glu Met Glu Gly Ser Trp Ile
                  80                  85                  90

 tga ttga tgatgcttgg cgagaagaca agctgcctta tgaggatgtc gcaataccac      767
 


 tgaatgagct tcctgaacct gaacaagaca atggtggcac cacagaatct gtcaaagaac    827

 aagaaatgaa gtggacagac ttagccttac agtacctcca tgagaatgtt ccccccattg    887

 gaaactgacg cttggctcct ttcttgtgga tggattttct caaagtacac agataaagca    947

 tggtttgttt cagtctccaa attcaaacct ttgagtaata aatcagcact caaaaatgta   1007

 cacccattta gtttgtggta gcaaagtgca atgcgaaatt gaatgagaaa ctgagatttc   1067

 tcagtaatgg tgaatatttc gctctttaaa cctaaaactc ttcattgagt agcttatatt   1127

 tgaacatgat tggttaaaca tttgcctcta cctctgattt tgctttgctg tcaaagttta   1187

 acaccttcca actacttatg tgtgtcctgt aacacaggtg attgaacgta tgagagggaa   1247

 aggcaaagaa aaaggaagcc agacactagg agaattatta acttctcata cttccccaca   1307

 ttgagaagca ttcggagtgt atttagcctg tagatgttgt gatatgcaaa tatcccattc   1367

 cctggttact ggcattccta agattcttca tggtattttc aaactttgga taaatttaca   1427

 gattagaaag atatctgaca gttaatctct gttctcctta caaattcctt ttgtgctgct   1487

 ggaaaggatc tttggctagg tggatgacta gttttattca aagccttttc tcaaagccct   1547

 ttcagttaca accaccccac tatggaatca gtatttagtt atacatttgt ataagaacct   1607

 gtattttgaa aaacacattc atgtatattt attcctggaa ttatttgcct gttaaacagt   1667

 gtctttcatg ttctctcccc agattgtaaa ctctgtaaga agctgcttgt atctgtatcc   1727

 cttgttgaaa ctctgaaaac actgaataac taaaatctct tctcatcctt ttaaaaaaaa   1787

 aaaaa                                                               1792




      <210> 30
      <211> 1292
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (205)..(1077)

      <400> 30
 cctcccgcct cctctaggcc gccggccgcg aagcgctgag tcacggtgag gcgactggac     60

 ccacactctc ttaacctgcc ctccctgcac tcgctcccgg cggctcttcg cgtcaccccc    120

 gccgctaagg ctccaggtgc cgctaccgca gcccctccat cctctacagc tcagcatcag    180

 aacactctct ttttagactc cgat   atg ggg tcc tcc aag aaa gtt act ctc     231
                              Met Gly Ser Ser Lys Lys Val Thr Leu
                                1               5

 tca gtg ctc agc cgg gag cag tcg gaa ggg gtt gga gcg agg gtc cgg      279
 Ser Val Leu Ser Arg Glu Gln Ser Glu Gly Val Gly Ala Arg Val Arg
  10                  15                  20                  25

 aga agc att ggc aga ccc gag tta aaa aat ctg gat ccg ttt tta ctg      327
 Arg Ser Ile Gly Arg Pro Glu Leu Lys Asn Leu Asp Pro Phe Leu Leu
                  30                  35                  40

 ttt gat gaa ttt aaa gga ggt aga cca gga gga ttt cct gat cat cca      375
 Phe Asp Glu Phe Lys Gly Gly Arg Pro Gly Gly Phe Pro Asp His Pro
              45                  50                  55

 cat cga ggt ttt gaa aca gta tcc tac ctc ctg gaa ggg ggc agc atg      423
 His Arg Gly Phe Glu Thr Val Ser Tyr Leu Leu Glu Gly Gly Ser Met
          60                  65                  70

 gcc cat gaa gac ttc tgt gga cac act ggt aaa atg aac cca gga gat      471
 Ala His Glu Asp Phe Cys Gly His Thr Gly Lys Met Asn Pro Gly Asp
      75                  80                  85

 ttg cag tgg atg act gcg ggc cgg ggc att ctg cac gct gag atg cct      519
 Leu Gln Trp Met Thr Ala Gly Arg Gly Ile Leu His Ala Glu Met Pro
  90                  95                 100                 105

 tgc tca gag gag cca gcc cat ggc cta caa ctg tgg gtt aat ttg agg      567
 Cys Ser Glu Glu Pro Ala His Gly Leu Gln Leu Trp Val Asn Leu Arg
                 110                 115                 120

 agc tca gag aag atg gtg gag cct cag tac cag gaa ctg aaa agt gaa      615
 Ser Ser Glu Lys Met Val Glu Pro Gln Tyr Gln Glu Leu Lys Ser Glu
             125                 130                 135

 gaa atc cct aaa ccc agt aag gat ggt gtg aca gtt gct gtc att tct      663
 Glu Ile Pro Lys Pro Ser Lys Asp Gly Val Thr Val Ala Val Ile Ser
         140                 145                 150

 gga gaa gcc ctg gga ata aag tcc aag gtt tac act cgc aca cca acc      711
 Gly Glu Ala Leu Gly Ile Lys Ser Lys Val Tyr Thr Arg Thr Pro Thr
     155                 160                 165

 tta tat ttg gac ttc aaa ttg gac cca gga gcc aaa cat tcc caa cct      759
 Leu Tyr Leu Asp Phe Lys Leu Asp Pro Gly Ala Lys His Ser Gln Pro
 170                 175                 180                 185

 atc cct aaa ggg tgg aca agc ttc att tac acg ata tct gga gat gtg      807
 Ile Pro Lys Gly Trp Thr Ser Phe Ile Tyr Thr Ile Ser Gly Asp Val
                 190                 195                 200

 tat att ggg ccc gat gat gca caa caa aaa ata gaa cct cat cac aca      855
 Tyr Ile Gly Pro Asp Asp Ala Gln Gln Lys Ile Glu Pro His His Thr
             205                 210                 215

 gca gtg ctt gga gaa ggt gac agt gtc caa gtg gag aac aag gat ccc      903
 Ala Val Leu Gly Glu Gly Asp Ser Val Gln Val Glu Asn Lys Asp Pro
         220                 225                 230

 aag aga agc cac ttt gtc tta att gct ggg gag cca tta aga gaa cca      951
 Lys Arg Ser His Phe Val Leu Ile Ala Gly Glu Pro Leu Arg Glu Pro
     235                 240                 245

 gtt atc caa cat ggt cca ttt gtg atg aac acc aat gaa gag att tct      999
 Val Ile Gln His Gly Pro Phe Val Met Asn Thr Asn Glu Glu Ile Ser
 250                 255                 260                 265

 caa gct att ctt gat ttc aga aac gca aaa aat ggg ttt gaa agg gcc     1047
 Gln Ala Ile Leu Asp Phe Arg Asn Ala Lys Asn Gly Phe Glu Arg Ala
                 270                 275                 280

 aaa acc tgg aaa tca aag att ggg aac tag t ggaaagcgga agagcaggtc     1098
 Lys Thr Trp Lys Ser Lys Ile Gly Asn 
             285                 290

 ttgatgtgtc ctagaatttt gccatttctg agattgagcc attgaaggca ttccatttct   1158

 aaagcttatt tagccggtgc ttctaaagaa ttccacacta acgtgataac atggtttttg   1218

 taacaataaa tgtaggatat ttcctggcac atgcaaataa acctaatcat tgtttcttta   1278

 aaaaaaaaaa aaaa                                                     1292




      <210> 31
      <211> 4146
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1914)

      <400> 31
  atg gcc aaa gaa gga agg tat gag tgt atc tgt ggg tgg gca ttt gta      48
  Met Ala Lys Glu Gly Arg Tyr Glu Cys Ile Cys Gly Trp Ala Phe Val
    1               5                  10                  15

 aag gat gtt cat gaa gat tca ata aca gtt gca ttt gaa aac aac tgg       96
 Lys Asp Val His Glu Asp Ser Ile Thr Val Ala Phe Glu Asn Asn Trp
              20                  25                  30

 cag cct gat agg cag att cca ttt cat gat gtc aga ttc cca cct cct      144
 Gln Pro Asp Arg Gln Ile Pro Phe His Asp Val Arg Phe Pro Pro Pro
          35                  40                  45

 gta ggt tat aat aaa gat ata aat gaa agt gat gaa gtt gag ttt tat      192
 Val Gly Tyr Asn Lys Asp Ile Asn Glu Ser Asp Glu Val Glu Phe Tyr
      50                  55                  60

 gtg ata gaa tat gca gca tgt gat gca act tac aat gaa att gtc aca      240
 Val Ile Glu Tyr Ala Ala Cys Asp Ala Thr Tyr Asn Glu Ile Val Thr
  65                  70                  75                  80

 att gaa cgt cta aga tct gtt aat ccc aac aaa cct gcc aca aaa gat      288
 Ile Glu Arg Leu Arg Ser Val Asn Pro Asn Lys Pro Ala Thr Lys Asp
                  85                  90                  95

 act ttc cat aag atc aag ctg gat gtg cca gaa gac tta cgg caa atg      336
 Thr Phe His Lys Ile Lys Leu Asp Val Pro Glu Asp Leu Arg Gln Met
             100                 105                 110

 tgt gcc aaa gag gcg gca cat aag gat ttt aaa aag gca gtt ggt gcc      384
 Cys Ala Lys Glu Ala Ala His Lys Asp Phe Lys Lys Ala Val Gly Ala
         115                 120                 125

 ttt tct gta act tat gat cca gaa aat tat cag ctt gtc att ttg tcc      432
 Phe Ser Val Thr Tyr Asp Pro Glu Asn Tyr Gln Leu Val Ile Leu Ser
     130                 135                 140

 atc aat gaa gtc acc tca aag cga gca cat atg ctg att gac atg cac      480
 Ile Asn Glu Val Thr Ser Lys Arg Ala His Met Leu Ile Asp Met His
 145                 150                 155                 160

 ttt cgg agt ctg cgc act aag ttg tct ctg ata atg aga aat gaa gaa      528
 Phe Arg Ser Leu Arg Thr Lys Leu Ser Leu Ile Met Arg Asn Glu Glu
                 165                 170                 175

 gct agt aag cag ctg gag agt tca agg cag ctt gcc tcg aga ttt cat      576
 Ala Ser Lys Gln Leu Glu Ser Ser Arg Gln Leu Ala Ser Arg Phe His
             180                 185                 190

 gaa cag ttt atc gta aga gaa gat ctg atg ggt cta gct att ggt act      624
 Glu Gln Phe Ile Val Arg Glu Asp Leu Met Gly Leu Ala Ile Gly Thr
         195                 200                 205

 cat ggt gct aat att cag caa gct aga aaa gta cct ggg gtc act gct      672
 His Gly Ala Asn Ile Gln Gln Ala Arg Lys Val Pro Gly Val Thr Ala
     210                 215                 220

 att gat cta gat gaa gat acc tgc aca ttt cat att tat gga gag gat      720
 Ile Asp Leu Asp Glu Asp Thr Cys Thr Phe His Ile Tyr Gly Glu Asp
 225                 230                 235                 240

 cag gat gca gtg aaa aaa gct aga agc ttt ctc gaa ttt gct gaa gat      768
 Gln Asp Ala Val Lys Lys Ala Arg Ser Phe Leu Glu Phe Ala Glu Asp
                 245                 250                 255

 gta ata caa gtt cca agg aac tta gta ggc aaa gta ata gga aaa aat      816
 Val Ile Gln Val Pro Arg Asn Leu Val Gly Lys Val Ile Gly Lys Asn
             260                 265                 270

 gga aag ctg att cag gag att gtg gac aag tca gga gtt gtg agg gtg      864
 Gly Lys Leu Ile Gln Glu Ile Val Asp Lys Ser Gly Val Val Arg Val
         275                 280                 285

 agg att gag gct gaa aat gag aaa aat gtt cca caa gaa gag gaa att      912
 Arg Ile Glu Ala Glu Asn Glu Lys Asn Val Pro Gln Glu Glu Glu Ile
     290                 295                 300

 atg cca cca aat tcc ctt cct tcc aat aat tca agg gtt gga cct aat      960
 Met Pro Pro Asn Ser Leu Pro Ser Asn Asn Ser Arg Val Gly Pro Asn
 305                 310                 315                 320

 gcc cca gaa gaa aaa aaa cat tta gat ata aag gaa aac agc acc cat     1008
 Ala Pro Glu Glu Lys Lys His Leu Asp Ile Lys Glu Asn Ser Thr His
                 325                 330                 335

 ttt tct caa cct aac agt aca aaa gtc cag agg gtg tta gtg gct tca     1056
 Phe Ser Gln Pro Asn Ser Thr Lys Val Gln Arg Val Leu Val Ala Ser
             340                 345                 350

 tca gtt gta gca ggg gaa tcc cag aaa cct gaa ctc aag gct tgg cag     1104
 Ser Val Val Ala Gly Glu Ser Gln Lys Pro Glu Leu Lys Ala Trp Gln
         355                 360                 365

 ggt atg gta cca ttt gtt ttt gtg gga aca aag gac agc atc gct aat     1152
 Gly Met Val Pro Phe Val Phe Val Gly Thr Lys Asp Ser Ile Ala Asn
     370                 375                 380

 gcc act gtt ctt ttg gat tat cac ctg aac tat tta aag gaa gta gac     1200
 Ala Thr Val Leu Leu Asp Tyr His Leu Asn Tyr Leu Lys Glu Val Asp
 385                 390                 395                 400

 cag ttg cgt ttg gag aga tta caa att gat gag cag ttg cga cag att     1248
 Gln Leu Arg Leu Glu Arg Leu Gln Ile Asp Glu Gln Leu Arg Gln Ile
                 405                 410                 415

 gga gct agt tct aga cca cca cca aat cgt aca gat aag gaa aaa agc     1296
 Gly Ala Ser Ser Arg Pro Pro Pro Asn Arg Thr Asp Lys Glu Lys Ser
             420                 425                 430

 tat gtg act gat gat ggt caa gga atg ggt cga ggt agt aga cct tac     1344
 Tyr Val Thr Asp Asp Gly Gln Gly Met Gly Arg Gly Ser Arg Pro Tyr
         435                 440                 445

 aga aat agg ggg cac ggc aga cgc ggt cct gga tat act tca gga act     1392
 Arg Asn Arg Gly His Gly Arg Arg Gly Pro Gly Tyr Thr Ser Gly Thr
     450                 455                 460

 aat tct gaa gca tca aat gct tct gaa aca gaa tct gac cac aga gac     1440
 Asn Ser Glu Ala Ser Asn Ala Ser Glu Thr Glu Ser Asp His Arg Asp
 465                 470                 475                 480

 gaa ctc agt gat tgg tca tta gct cca aca gag gaa gag agg gag agc     1488
 Glu Leu Ser Asp Trp Ser Leu Ala Pro Thr Glu Glu Glu Arg Glu Ser
                 485                 490                 495

 ttc ctg cgc aga gga gac gga cgg cgg cgt gga ggg gga gga aga gga     1536
 Phe Leu Arg Arg Gly Asp Gly Arg Arg Arg Gly Gly Gly Gly Arg Gly
             500                 505                 510

 caa gga gga aga gga cgt gga gga ggc ttc aaa gat tct gtg gtt ggt     1584
 Gln Gly Gly Arg Gly Arg Gly Gly Gly Phe Lys Asp Ser Val Val Gly
         515                 520                 525

 tta aat aga ggg tgt ggg aat aaa gaa ctt cca gta agc att tca gaa     1632
 Leu Asn Arg Gly Cys Gly Asn Lys Glu Leu Pro Val Ser Ile Ser Glu
     530                 535                 540

 tca gta act gtt gaa cct ttt gaa aat att ctc ata gga aac gac gat     1680
 Ser Val Thr Val Glu Pro Phe Glu Asn Ile Leu Ile Gly Asn Asp Asp
 545                 550                 555                 560

 cac tcc cga aca gat aat cgt cca cgt aat cca aga gag gct aaa gga     1728
 His Ser Arg Thr Asp Asn Arg Pro Arg Asn Pro Arg Glu Ala Lys Gly
                 565                 570                 575

 aga aca aca gat gga tcc ctt cag atc aga gtt gac tgc aat aat gaa     1776
 Arg Thr Thr Asp Gly Ser Leu Gln Ile Arg Val Asp Cys Asn Asn Glu
             580                 585                 590

 agg agt gtc cac act aaa aca tta cag aat acc tcc agt gaa ggt agt     1824
 Arg Ser Val His Thr Lys Thr Leu Gln Asn Thr Ser Ser Glu Gly Ser
         595                 600                 605

 cgg ctg cgc acg ggt aaa gat cgt aac cag aag aaa gag aag cca gac     1872
 Arg Leu Arg Thr Gly Lys Asp Arg Asn Gln Lys Lys Glu Lys Pro Asp
     610                 615                 620

 agc gtg gat ggt cag caa cca ctc gtg aat gga gta ccc taa actgcat     1921
 Ser Val Asp Gly Gln Gln Pro Leu Val Asn Gly Val Pro 
 625                 630                 635

 aattctgaag ttatatttcc tataccattt ccgtaattct tattccatat tagaaaactt   1981

 tgttaggcca aagacaaata gtaggcaaga tggcacaggg catgaaatga acacaaatta   2041

 tgctaagaat tttttatttt ttggtattgg ccataagcaa caattttcag atttgcacaa   2101

 aaagatacct taaaatttga aacattgctt ttaaaactac ttagcacttc agggcagatt   2161

 ttagttttat tttctaaagt actgagcagt gatattcttt gttaatttgg accattttcc   2221

 tgcattgggt gatcattcac cagtacattc tcagtttttc ttaatatata gcatttatgg   2281

 taatcatatt agacttctgt tttcaatctc gtatagaagt cttcatgaaa tgctatgtca   2341

 tttcatgtcc tgtgtcagtt tatgttttgg tccacttttc cagtatttta gtggaccctg   2401

 aaatgtgtgt gatgtgacat ttgtcatttt cattagcaaa aaaagttgta tgatctgtgc   2461

 cttttttata tcttggcagg taggaatatt atatttggat gcagagttca gggaagataa   2521

 gttggaaaca ctaaatgtta aagatgtagc aaaccctgtc aaacattagt actttataga   2581

 agaatgcatg ctttccatat ttttttcctt acataaacat caggttaggc agtataaaga   2641

 ataggacttg tttttgtttt tgttttgttg cactgaagtt tgataaatag tgttattgag   2701

 agagatgtgt aatttttctg tatagacagg agaagaaaga actatcttca tctgagagag   2761

 gctaaaatgt tttcagccag gaacaaatct tcctggtcga aagttagtag gatatgcctg   2821

 ctctttggcc tgatgaccaa ttttaactta gagctttttt tttttaattt tgtctgcccc   2881

 aagttttgtg aaatttttca tattttaatt tcaagcttat tttggagaga taggaaggtc   2941

 atttccatgt atgcataata atcctgcaaa gtacaggtac tttgtctaag aaacattgga   3001

 agcaggttaa atgttttgta aactttgaaa tatatggtct aatgtttaag cagaattgga   3061

 aaagactaag atcggttaac aaataacaac ttttttttct ttttttcttt tgttttttga   3121

 agtgttgggg tttggttttg ttttttgagt cttttttttt taagtgaaat ttattgagga   3181

 aaaatatgtg aaggaccttc actctaagat gttatatttt tcttaaaaag taactcctag   3241

 taggggtacc actgaatctg tacagagccg taaaaactga agttctgcct ctgatgtatt   3301

 ttgtgagttt gtttctttga attttcattt tacagttact tttccttgca tacaaacaag   3361

 catataaaat ggcaacaaac tgcacatgat ttcacaaata ttaaaaagtc ttttaaaaag   3421

 tattgccaaa cattaatgtt gatttctagt tatttattct gggaatgtat agtatttgaa   3481

 aacagaaatt ggtaccttgc acacatcatc tgtaagctgt ttggttttaa aatactgtag   3541

 ataattaacc aaggtagaat gaccttgtaa tgtaactgct cttgggcaat attctctgta   3601

 catattagcg acaacagatt ggattttatg ttgacatttg tttggttata gtgcaatata   3661

 ttttgtatgc aagcagtttc aataaagttt gatcttcctc tgctaaattg atgttgatgc   3721

 aatccttaca aatgattgct tttaaaattt taagctagga aaagaaatct atagaaagtg   3781

 ttctgttaca aaatgtaact gttaccattg gaaatttcac gtcataggaa gttagccttt   3841

 atctaccaac tttcaagaac ttgtttaata aagcgaaaaa ctcaaccaaa tggtacaaaa   3901

 ccacagtgta ccattaaaat atgcactaag tctctttttt acaaaggctg tattcagcaa   3961

 ggcgctaact tgcttaaatg tgaattacta acttctaaaa ctgtactttg attcacatgt   4021

 tttcaaatgg agttggagtt cattcatatt acaatatttg tgtgctaaac gtgtatgttt   4081

 ttcagttcaa agtcatgatg tttttaaaat cttattaaag tttcaaaaat ctgaaaaaaa   4141

 aaaaa                                                               4146




      <210> 32
      <211> 4083
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1851)

      <400> 32
  atg gcc aaa gaa gga agg tat gag tgt atc tgt ggg tgg gca ttt gta      48
  Met Ala Lys Glu Gly Arg Tyr Glu Cys Ile Cys Gly Trp Ala Phe Val
    1               5                  10                  15

 aag gat gtt cat gaa gat tca ata aca gtt gca ttt gaa aac aac tgg       96
 Lys Asp Val His Glu Asp Ser Ile Thr Val Ala Phe Glu Asn Asn Trp
              20                  25                  30

 cag cct gat agg cag att cca ttt cat gat gtc aga ttc cca cct cct      144
 Gln Pro Asp Arg Gln Ile Pro Phe His Asp Val Arg Phe Pro Pro Pro
          35                  40                  45

 gta ggt tat aat aaa gat ata aat gaa agt gat gaa gtt gag ttt tat      192
 Val Gly Tyr Asn Lys Asp Ile Asn Glu Ser Asp Glu Val Glu Phe Tyr
      50                  55                  60

 gtg ata gaa tat gca gca tgt gat gca act tac aat gaa att gtc aca      240
 Val Ile Glu Tyr Ala Ala Cys Asp Ala Thr Tyr Asn Glu Ile Val Thr
  65                  70                  75                  80

 att gaa cgt cta aga tct gtt aat ccc aac aaa cct gcc aca aaa gat      288
 Ile Glu Arg Leu Arg Ser Val Asn Pro Asn Lys Pro Ala Thr Lys Asp
                  85                  90                  95

 act ttc cat aag atc aag ctg gat gtg cca gaa gac tta cgg caa atg      336
 Thr Phe His Lys Ile Lys Leu Asp Val Pro Glu Asp Leu Arg Gln Met
             100                 105                 110

 tgt gcc aaa gag gcg gca cat aag gat ttt aaa aag gca gtt ggt gcc      384
 Cys Ala Lys Glu Ala Ala His Lys Asp Phe Lys Lys Ala Val Gly Ala
         115                 120                 125

 ttt tct gta act tat gat cca gaa aat tat cag ctt gtc att ttg tcc      432
 Phe Ser Val Thr Tyr Asp Pro Glu Asn Tyr Gln Leu Val Ile Leu Ser
     130                 135                 140

 atc aat gaa gtc acc tca aag cga gca cat atg ctg att gac atg cac      480
 Ile Asn Glu Val Thr Ser Lys Arg Ala His Met Leu Ile Asp Met His
 145                 150                 155                 160

 ttt cgg agt ctg cgc act aag ttg tct ctg ata atg aga aat gaa gaa      528
 Phe Arg Ser Leu Arg Thr Lys Leu Ser Leu Ile Met Arg Asn Glu Glu
                 165                 170                 175

 gct agt aag cag ctg gag agt tca agg cag ctt gcc tcg aga ttt cat      576
 Ala Ser Lys Gln Leu Glu Ser Ser Arg Gln Leu Ala Ser Arg Phe His
             180                 185                 190

 gaa cag ttt atc gta aga gaa gat ctg atg ggt cta gct att ggt act      624
 Glu Gln Phe Ile Val Arg Glu Asp Leu Met Gly Leu Ala Ile Gly Thr
         195                 200                 205

 cat ggt gct aat att cag caa gct aga aaa gta cct ggg gtc act gct      672
 His Gly Ala Asn Ile Gln Gln Ala Arg Lys Val Pro Gly Val Thr Ala
     210                 215                 220

 att gat cta gat gaa gat acc tgc aca ttt cat att tat gga gag gat      720
 Ile Asp Leu Asp Glu Asp Thr Cys Thr Phe His Ile Tyr Gly Glu Asp
 225                 230                 235                 240

 cag gat gca gtg aaa aaa gct aga agc ttt ctc gaa ttt gct gaa gat      768
 Gln Asp Ala Val Lys Lys Ala Arg Ser Phe Leu Glu Phe Ala Glu Asp
                 245                 250                 255

 gta ata caa gtt cca agg aac tta gta ggc aaa gta ata gga aaa aat      816
 Val Ile Gln Val Pro Arg Asn Leu Val Gly Lys Val Ile Gly Lys Asn
             260                 265                 270

 gga aag ctg att cag gag att gtg gac aag tca gga gtt gtg agg gtg      864
 Gly Lys Leu Ile Gln Glu Ile Val Asp Lys Ser Gly Val Val Arg Val
         275                 280                 285

 agg att gag gct gaa aat gag aaa aat gtt cca caa gaa gag gaa att      912
 Arg Ile Glu Ala Glu Asn Glu Lys Asn Val Pro Gln Glu Glu Glu Ile
     290                 295                 300

 atg cca cca aat tcc ctt cct tcc aat aat tca agg gtt gga cct aat      960
 Met Pro Pro Asn Ser Leu Pro Ser Asn Asn Ser Arg Val Gly Pro Asn
 305                 310                 315                 320

 gcc cca gaa gaa aaa aaa cat tta gat ata aag gaa aac agc acc cat     1008
 Ala Pro Glu Glu Lys Lys His Leu Asp Ile Lys Glu Asn Ser Thr His
                 325                 330                 335

 ttt tct caa cct aac agt aca aaa gtc cag agg ggt atg gta cca ttt     1056
 Phe Ser Gln Pro Asn Ser Thr Lys Val Gln Arg Gly Met Val Pro Phe
             340                 345                 350

 gtt ttt gtg gga aca aag gac agc atc gct aat gcc act gtt ctt ttg     1104
 Val Phe Val Gly Thr Lys Asp Ser Ile Ala Asn Ala Thr Val Leu Leu
         355                 360                 365

 gat tat cac ctg aac tat tta aag gaa gta gac cag ttg cgt ttg gag     1152
 Asp Tyr His Leu Asn Tyr Leu Lys Glu Val Asp Gln Leu Arg Leu Glu
     370                 375                 380

 aga tta caa att gat gag cag ttg cga cag att gga gct agt tct aga     1200
 Arg Leu Gln Ile Asp Glu Gln Leu Arg Gln Ile Gly Ala Ser Ser Arg
 385                 390                 395                 400

 cca cca cca aat cgt aca gat aag gaa aaa agc tat gtg act gat gat     1248
 Pro Pro Pro Asn Arg Thr Asp Lys Glu Lys Ser Tyr Val Thr Asp Asp
                 405                 410                 415

 ggt caa gga atg ggt cga ggt agt aga cct tac aga aat agg ggg cac     1296
 Gly Gln Gly Met Gly Arg Gly Ser Arg Pro Tyr Arg Asn Arg Gly His
             420                 425                 430

 ggc aga cgc ggt cct gga tat act tca gga act aat tct gaa gca tca     1344
 Gly Arg Arg Gly Pro Gly Tyr Thr Ser Gly Thr Asn Ser Glu Ala Ser
         435                 440                 445

 aat gct tct gaa aca gaa tct gac cac aga gac gaa ctc agt gat tgg     1392
 Asn Ala Ser Glu Thr Glu Ser Asp His Arg Asp Glu Leu Ser Asp Trp
     450                 455                 460

 tca tta gct cca aca gag gaa gag agg gag agc ttc ctg cgc aga gga     1440
 Ser Leu Ala Pro Thr Glu Glu Glu Arg Glu Ser Phe Leu Arg Arg Gly
 465                 470                 475                 480

 gac gga cgg cgg cgt gga ggg gga gga aga gga caa gga gga aga gga     1488
 Asp Gly Arg Arg Arg Gly Gly Gly Gly Arg Gly Gln Gly Gly Arg Gly
                 485                 490                 495

 cgt gga gga ggc ttc aaa gat tct gtg gtt ggt tta aat aga ggg tgt     1536
 Arg Gly Gly Gly Phe Lys Asp Ser Val Val Gly Leu Asn Arg Gly Cys
             500                 505                 510

 ggg aat aaa gaa ctt cca gta agc att tca gaa tca gta act gtt gaa     1584
 Gly Asn Lys Glu Leu Pro Val Ser Ile Ser Glu Ser Val Thr Val Glu
         515                 520                 525

 cct ttt gaa aat att ctc ata gga aac gac gat cac tcc cga aca gat     1632
 Pro Phe Glu Asn Ile Leu Ile Gly Asn Asp Asp His Ser Arg Thr Asp
     530                 535                 540

 aat cgt cca cgt aat cca aga gag gct aaa gga aga aca aca gat gga     1680
 Asn Arg Pro Arg Asn Pro Arg Glu Ala Lys Gly Arg Thr Thr Asp Gly
 545                 550                 555                 560

 tcc ctt cag atc aga gtt gac tgc aat aat gaa agg agt gtc cac act     1728
 Ser Leu Gln Ile Arg Val Asp Cys Asn Asn Glu Arg Ser Val His Thr
                 565                 570                 575

 aaa aca tta cag aat acc tcc agt gaa ggt agt cgg ctg cgc acg ggt     1776
 Lys Thr Leu Gln Asn Thr Ser Ser Glu Gly Ser Arg Leu Arg Thr Gly
             580                 585                 590

 aaa gat cgt aac cag aag aaa gag aag cca gac agc gtg gat ggt cag     1824
 Lys Asp Arg Asn Gln Lys Lys Glu Lys Pro Asp Ser Val Asp Gly Gln
         595                 600                 605

 caa cca ctc gtg aat gga gta ccc taa actgc ataattctga agttatattt     1876
 Gln Pro Leu Val Asn Gly Val Pro 
     610                 615

 cctataccat ttccgtaatt cttattccat attagaaaac tttgttaggc caaagacaaa   1936

 tagtaggcaa gatggcacag ggcatgaaat gaacacaaat tatgctaaga attttttatt   1996

 ttttggtatt ggccataagc aacaattttc agatttgcac aaaaagatac cttaaaattt   2056

 gaaacattgc ttttaaaact acttagcact tcagggcaga ttttagtttt attttctaaa   2116

 gtactgagca gtgatattct ttgttaattt ggaccatttt cctgcattgg gtgatcattc   2176

 accagtacat tctcagtttt tcttaatata tagcatttat ggtaatcata ttagacttct   2236

 gttttcaatc tcgtatagaa gtcttcatga aatgctatgt catttcatgt cctgtgtcag   2296

 tttatgtttt ggtccacttt tccagtattt tagtggaccc tgaaatgtgt gtgatgtgac   2356

 atttgtcatt ttcattagca aaaaaagttg tatgatctgt gcctttttta tatcttggca   2416

 ggtaggaata ttatatttgg atgcagagtt cagggaagat aagttggaaa cactaaatgt   2476

 taaagatgta gcaaaccctg tcaaacatta gtactttata gaagaatgca tgctttccat   2536

 atttttttcc ttacataaac atcaggttag gcagtataaa gaataggact tgtttttgtt   2596

 tttgttttgt tgcactgaag tttgataaat agtgttattg agagagatgt gtaatttttc   2656

 tgtatagaca ggagaagaaa gaactatctt catctgagag aggctaaaat gttttcagcc   2716

 aggaacaaat cttcctggtc gaaagttagt aggatatgcc tgctctttgg cctgatgacc   2776

 aattttaact tagagctttt tttttttaat tttgtctgcc ccaagttttg tgaaattttt   2836

 catattttaa tttcaagctt attttggaga gataggaagg tcatttccat gtatgcataa   2896

 taatcctgca aagtacaggt actttgtcta agaaacattg gaagcaggtt aaatgttttg   2956

 taaactttga aatatatggt ctaatgttta agcagaattg gaaaagacta agatcggtta   3016

 acaaataaca actttttttt ctttttttct tttgtttttt gaagtgttgg ggtttggttt   3076

 tgttttttga gtcttttttt tttaagtgaa atttattgag gaaaaatatg tgaaggacct   3136

 tcactctaag atgttatatt tttcttaaaa agtaactcct agtaggggta ccactgaatc   3196

 tgtacagagc cgtaaaaact gaagttctgc ctctgatgta ttttgtgagt ttgtttcttt   3256

 gaattttcat tttacagtta cttttccttg catacaaaca agcatataaa atggcaacaa   3316

 actgcacatg atttcacaaa tattaaaaag tcttttaaaa agtattgcca aacattaatg   3376

 ttgatttcta gttatttatt ctgggaatgt atagtatttg aaaacagaaa ttggtacctt   3436

 gcacacatca tctgtaagct gtttggtttt aaaatactgt agataattaa ccaaggtaga   3496

 atgaccttgt aatgtaactg ctcttgggca atattctctg tacatattag cgacaacaga   3556

 ttggatttta tgttgacatt tgtttggtta tagtgcaata tattttgtat gcaagcagtt   3616

 tcaataaagt ttgatcttcc tctgctaaat tgatgttgat gcaatcctta caaatgattg   3676

 cttttaaaat tttaagctag gaaaagaaat ctatagaaag tgttctgtta caaaatgtaa   3736

 ctgttaccat tggaaatttc acgtcatagg aagttagcct ttatctacca actttcaaga   3796

 acttgtttaa taaagcgaaa aactcaacca aatggtacaa aaccacagtg taccattaaa   3856

 atatgcacta agtctctttt ttacaaaggc tgtattcagc aaggcgctaa cttgcttaaa   3916

 tgtgaattac taacttctaa aactgtactt tgattcacat gttttcaaat ggagttggag   3976

 ttcattcata ttacaatatt tgtgtgctaa acgtgtatgt ttttcagttc aaagtcatga   4036

 tgtttttaaa atcttattaa agtttcaaaa atctgaaaaa aaaaaaa                 4083




      <210> 33
      <211> 1616
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (73)..(1362)

      <400> 33
 gggggagcac tagcagcagc cggagtcggc ggaaagcacc cgggcgcagc cggagccggt     60

 gccgcagctg cg    atg gcc gtg gcc gtg ggg aga ccg tct aat gaa gag     108
                  Met Ala Val Ala Val Gly Arg Pro Ser Asn Glu Glu
                    1               5                  10

 ctt cga aac ttg tct ttg tct ggc cat gtg gga ttt gac agc ctc cct      156
 Leu Arg Asn Leu Ser Leu Ser Gly His Val Gly Phe Asp Ser Leu Pro
          15                  20                  25

 gac cag ctg gtc aac aag tct act tct caa gga ttc tgt ttc aac atc      204
 Asp Gln Leu Val Asn Lys Ser Thr Ser Gln Gly Phe Cys Phe Asn Ile
      30                  35                  40

 ctt tgt gtt ggt gag aca ggc att ggc aaa tcc acg tta atg gac act      252
 Leu Cys Val Gly Glu Thr Gly Ile Gly Lys Ser Thr Leu Met Asp Thr
  45                  50                  55                  60

 ttg ttc aac acc aaa ttt gaa agt gac cca gct act cac aat gaa cca      300
 Leu Phe Asn Thr Lys Phe Glu Ser Asp Pro Ala Thr His Asn Glu Pro
                  65                  70                  75

 ggt gtt cgg tta aaa gcc aga agt tat gag ctt cag gaa agc aat gta      348
 Gly Val Arg Leu Lys Ala Arg Ser Tyr Glu Leu Gln Glu Ser Asn Val
              80                  85                  90

 cgg ctg aag tta acc att gtt gac acc gtg gga ttt gga gac cag ata      396
 Arg Leu Lys Leu Thr Ile Val Asp Thr Val Gly Phe Gly Asp Gln Ile
          95                 100                 105

 aat aaa gat gac agc tat aag ccg ata gta gaa tat att gat gcc cag      444
 Asn Lys Asp Asp Ser Tyr Lys Pro Ile Val Glu Tyr Ile Asp Ala Gln
     110                 115                 120

 ttc gag gcc tac ctg caa gag gaa ttg aag att aaa cgt tct ctc ttc      492
 Phe Glu Ala Tyr Leu Gln Glu Glu Leu Lys Ile Lys Arg Ser Leu Phe
 125                 130                 135                 140

 aac tac cat gac acg agg atc cat gcc tgc ctc tac ttt att gcc cct      540
 Asn Tyr His Asp Thr Arg Ile His Ala Cys Leu Tyr Phe Ile Ala Pro
                 145                 150                 155

 act gga cat tca cta aag tcc ctg gat ctg gtc acc atg aaa aag ctg      588
 Thr Gly His Ser Leu Lys Ser Leu Asp Leu Val Thr Met Lys Lys Leu
             160                 165                 170

 gac agt aag gtg aac atc att cca ata att gca aaa gct gac acc att      636
 Asp Ser Lys Val Asn Ile Ile Pro Ile Ile Ala Lys Ala Asp Thr Ile
         175                 180                 185

 gcc aag aat gaa ctg cac aaa ttc aag agt aag atc atg agt gaa ctg      684
 Ala Lys Asn Glu Leu His Lys Phe Lys Ser Lys Ile Met Ser Glu Leu
     190                 195                 200

 gtc agc aat ggg gtc cag ata tat cag ttt ccc act gat gaa gaa acg      732
 Val Ser Asn Gly Val Gln Ile Tyr Gln Phe Pro Thr Asp Glu Glu Thr
 205                 210                 215                 220

 gtg gca gag att aac gca aca atg agt gtc cat ctc cca ttt gca gtg      780
 Val Ala Glu Ile Asn Ala Thr Met Ser Val His Leu Pro Phe Ala Val
                 225                 230                 235

 gtt ggc agc acc gaa gag gtg aag att ggc aac aag atg gca aag gcc      828
 Val Gly Ser Thr Glu Glu Val Lys Ile Gly Asn Lys Met Ala Lys Ala
             240                 245                 250

 agg cag tac ccc tgg ggt gtg gtg cag gtt gag aat gaa aat cat tgc      876
 Arg Gln Tyr Pro Trp Gly Val Val Gln Val Glu Asn Glu Asn His Cys
         255                 260                 265

 gat ttt gtg aaa ctt cga gag atg ctg atc cgc gtg aac atg gag gac      924
 Asp Phe Val Lys Leu Arg Glu Met Leu Ile Arg Val Asn Met Glu Asp
     270                 275                 280

 ttg cga gag cag act cac acc cgc cac tat gaa ttg tac cga cgc tgt      972
 Leu Arg Glu Gln Thr His Thr Arg His Tyr Glu Leu Tyr Arg Arg Cys
 285                 290                 295                 300

 aag ctt gaa gag atg ggg ttc aag gac act gac cct gac agc aaa ccc     1020
 Lys Leu Glu Glu Met Gly Phe Lys Asp Thr Asp Pro Asp Ser Lys Pro
                 305                 310                 315

 ttc agt ctt cag gag aca tat gaa gca aaa agg aat gaa ttc ctg gga     1068
 Phe Ser Leu Gln Glu Thr Tyr Glu Ala Lys Arg Asn Glu Phe Leu Gly
             320                 325                 330

 gaa ctg cag aag aaa gaa gaa gaa atg aga caa atg ttt gtt atg aga     1116
 Glu Leu Gln Lys Lys Glu Glu Glu Met Arg Gln Met Phe Val Met Arg
         335                 340                 345

 gtg aag gag aaa gaa gct gaa ctt aag gag gca gag aaa gag ctt cac     1164
 Val Lys Glu Lys Glu Ala Glu Leu Lys Glu Ala Glu Lys Glu Leu His
     350                 355                 360

 gag aag ttt gac ctt cta aag cgg aca cac caa gaa aaa aaa aaa aaa     1212
 Glu Lys Phe Asp Leu Leu Lys Arg Thr His Gln Glu Lys Lys Lys Lys
 365                 370                 375                 380

 gtg gaa gac aag aag aag gag ctt gag gag gag gtg aac aac ttc cag     1260
 Val Glu Asp Lys Lys Lys Glu Leu Glu Glu Glu Val Asn Asn Phe Gln
                 385                 390                 395

 aag aag aaa gca gcg gct cag tta cta cag tcc cag gcc cag caa tct     1308
 Lys Lys Lys Ala Ala Ala Gln Leu Leu Gln Ser Gln Ala Gln Gln Ser
             400                 405                 410

 ggg gcc cag caa acc aag aaa gac aag gat aag aaa aac ttc ttc ttt     1356
 Gly Ala Gln Gln Thr Lys Lys Asp Lys Asp Lys Lys Asn Phe Phe Phe
         415                 420                 425

 atg taa ccatcctgtt gacaagccct actctctcct aatggacata gagcattaga      1412
 Met 


 agagcaggag ctgtctgttc acacgtgttg gggaagagtt acctcatttc caccatcgcc   1472

 tcctgttctt ttaaagtctg ggccatatat tgcactgctg tttgtacttg tcaatgtatg   1532

 cccatagtgg atactgaagt gacttaccac taccaaaaat agtcatattc aattatatta   1592

 attaaaaagg ataaaggaac ttgg                                          1616




      <210> 34
      <211> 1273
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (271)..(672)

      <400> 34
 taagcttgcg gccgcaacgt ctgcaagttc gcgctgcaca gcggctacag cagctacagc     60

 ctcagccgcg cgccggacgg cgccgccctg gccaccgcgc gcgcctcgcc ccggcaggaa    120

 aaggatgcgc ctccacttag caaggctggg caggatgtgg ttctgcatct gcccacagac    180

 ggggtggttc tagacggccg cgagagcaca gatgaccacg ccatcgtcca gtatgagtgg    240

 gcactgctgc agggggaccc gtcagtggac     atg aag gtg cct caa tca ggg     291
                                      Met Lys Val Pro Gln Ser Gly
                                        1               5

 ggt gac tcc ttg gtg gaa aag tct cag aaa gcc act gcc cca aac aag      339
 Gly Asp Ser Leu Val Glu Lys Ser Gln Lys Ala Thr Ala Pro Asn Lys
          10                  15                  20

 cca cct gca tta tca aac aca gag aag agg aat cat tcc gcc ttt tgg      387
 Pro Pro Ala Leu Ser Asn Thr Glu Lys Arg Asn His Ser Ala Phe Trp
      25                  30                  35

 gga cca gag agt caa atc att cct gtg atg cca gat agt agt tcc tca      435
 Gly Pro Glu Ser Gln Ile Ile Pro Val Met Pro Asp Ser Ser Ser Ser
  40                  45                  50                  55

 ggg aag aac aga aaa gag gaa agt tat ata ttt gag tca aag ggt gat      483
 Gly Lys Asn Arg Lys Glu Glu Ser Tyr Ile Phe Glu Ser Lys Gly Asp
                  60                  65                  70

 gga gga gga ggg gaa cac cca gcc cca gaa aca ggt gca gtg cta ccc      531
 Gly Gly Gly Gly Glu His Pro Ala Pro Glu Thr Gly Ala Val Leu Pro
              75                  80                  85

 ctg gcg ctg ggt ttg gct atc act gct ctg ctg ctt ctc atg gtt gca      579
 Leu Ala Leu Gly Leu Ala Ile Thr Ala Leu Leu Leu Leu Met Val Ala
          90                  95                 100

 tgc cga cta cga ctg gtg aaa cag aaa ctg aaa aaa gct cgt ccc att      627
 Cys Arg Leu Arg Leu Val Lys Gln Lys Leu Lys Lys Ala Arg Pro Ile
     105                 110                 115

 aca tct gag gaa tcg gac tac ctc ata aat ggg atg tat cta tag taa      675
 Thr Ser Glu Glu Ser Asp Tyr Leu Ile Asn Gly Met Tyr Leu 
 120                 125                 130

 tgtaatttca ataccttggg gcagggacat gttttgttta taatttatac atctattaag    735

 ttctggatat ttacagcttc ttttgttttt aattgggcca gaagattctg caaatcccaa    795

 atctttcttt attatttatt gtaaaaaaaa ggttccttag aagtcataaa atattttgaa    855

 atttagagag gaattcatga ttaaagattc ctaaaaatat aattctgatt tatgtaagct    915

 gtccctgaaa atagaaatgt gtacttagct gagagaaaat tcagcatctc aggaggtggt    975

 attaggatga ctgtgttaac ccattacctt ttagaagcca actgttggcc ccttaccatg   1035

 ctggactgct ataggcccag cttccccttg ttctgtggcc cttttcttcc tccttgaagc   1095

 tcccagtatt ctttttcttt tcccctctaa acctgtttct gagagtggat ctcaagcaag   1155

 ttcatgcctt caatcagatg ttacttaggg tgggtatacc taaattataa accttatgta   1215

 caagtcaggt cgacgcggcc gcgaattcca gatctatgaa ccgtagatac tgaaaaag     1273




      <210> 35
      <211> 1611
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1377)

      <400> 35
  atg gag cgc ggc cct ggg gcc cgg ggg cgc ggg ccg ggg tgt ggg gcc      48
  Met Glu Arg Gly Pro Gly Ala Arg Gly Arg Gly Pro Gly Cys Gly Ala
    1               5                  10                  15

 ctg gcc acc tcg gtg tgc ccc ttc gtc tcc ggg gtc tcc agg ggc ctg       96
 Leu Ala Thr Ser Val Cys Pro Phe Val Ser Gly Val Ser Arg Gly Leu
              20                  25                  30

 ctg ctg tcc act ggg ctc tca gga ccc agc tgc atg atg cca cct aaa      144
 Leu Leu Ser Thr Gly Leu Ser Gly Pro Ser Cys Met Met Pro Pro Lys
          35                  40                  45

 ctg cag ggc cct cca agt ccc cag cac cag cgg ggc agc acc gag cct      192
 Leu Gln Gly Pro Pro Ser Pro Gln His Gln Arg Gly Ser Thr Glu Pro
      50                  55                  60

 ttg ttt gtt gta ttt cct ctg tct cca gac atc gca ggc cgg ccg ggc      240
 Leu Phe Val Val Phe Pro Leu Ser Pro Asp Ile Ala Gly Arg Pro Gly
  65                  70                  75                  80

 ggc gtt gtt ggc ggg ggc ccc ggt gga ggc ccg gcc tgg gcg gcg ccc      288
 Gly Val Val Gly Gly Gly Pro Gly Gly Gly Pro Ala Trp Ala Ala Pro
                  85                  90                  95

 gcc atg aat ggg ctg tcg ctg agt gag ctc tgc tgc ctc ttc tgc tgc      336
 Ala Met Asn Gly Leu Ser Leu Ser Glu Leu Cys Cys Leu Phe Cys Cys
             100                 105                 110

 ccg ccc tgc ccc ggc cgc atc gct gcc aag ctc gcc ttc ctg ccg ccg      384
 Pro Pro Cys Pro Gly Arg Ile Ala Ala Lys Leu Ala Phe Leu Pro Pro
         115                 120                 125

 gag gcc acc tac tcc ctg gtg cct gag ccc gag ccg ggg cct ggt ggg      432
 Glu Ala Thr Tyr Ser Leu Val Pro Glu Pro Glu Pro Gly Pro Gly Gly
     130                 135                 140

 gcc ggg gcc gcc ccc ttg ggg acc ctg aga gcc tcc tcg ggc gca ccc      480
 Ala Gly Ala Ala Pro Leu Gly Thr Leu Arg Ala Ser Ser Gly Ala Pro
 145                 150                 155                 160

 ggg cgc tgg aag ctg cac ctg acg gag cgt gcc gac ttc cag tac agc      528
 Gly Arg Trp Lys Leu His Leu Thr Glu Arg Ala Asp Phe Gln Tyr Ser
                 165                 170                 175

 cag cgc gag ctg gac acc atc gag gtc ttc ccc acc aag agc gcc cgc      576
 Gln Arg Glu Leu Asp Thr Ile Glu Val Phe Pro Thr Lys Ser Ala Arg
             180                 185                 190

 ggc aac cgc gtc tcc tgc atg tat gtt cgc tgc gtg cct ggt gcc aga      624
 Gly Asn Arg Val Ser Cys Met Tyr Val Arg Cys Val Pro Gly Ala Arg
         195                 200                 205

 caa gga cac cag gct cag gga ggc cat ccc cag ctg gca tgg gtg ggc      672
 Gln Gly His Gln Ala Gln Gly Gly His Pro Gln Leu Ala Trp Val Gly
     210                 215                 220

 agg ctg ggc gac tcc aac aac cca gcg cct ggt ggt tgc ctg ctg ggc      720
 Arg Leu Gly Asp Ser Asn Asn Pro Ala Pro Gly Gly Cys Leu Leu Gly
 225                 230                 235                 240

 aag agc tgg ggc aca ggg gct gcc ctg gcc tgc ggg tac atc cac ctt      768
 Lys Ser Trp Gly Thr Gly Ala Ala Leu Ala Cys Gly Tyr Ile His Leu
                 245                 250                 255

 ctc gcc agg tac acg gtc ctc ttc tcg cac ggc aat gcc gtg gac ctg      816
 Leu Ala Arg Tyr Thr Val Leu Phe Ser His Gly Asn Ala Val Asp Leu
             260                 265                 270

 ggc cag atg agc agc ttc tac att ggc ctg ggc tcc cgc ctc cac tgc      864
 Gly Gln Met Ser Ser Phe Tyr Ile Gly Leu Gly Ser Arg Leu His Cys
         275                 280                 285

 aac atc ttc tcc tac gac tac tcc ggc tac ggt gcc agc tcg ggc agg      912
 Asn Ile Phe Ser Tyr Asp Tyr Ser Gly Tyr Gly Ala Ser Ser Gly Arg
     290                 295                 300

 cct tcc gag agg aac ctc tat gcc gac atc gac gcc gcc tgg cag gcc      960
 Pro Ser Glu Arg Asn Leu Tyr Ala Asp Ile Asp Ala Ala Trp Gln Ala
 305                 310                 315                 320

 ctg cgc acc agg tac ggc atc agc ccg gac agc atc atc ctg tac ggg     1008
 Leu Arg Thr Arg Tyr Gly Ile Ser Pro Asp Ser Ile Ile Leu Tyr Gly
                 325                 330                 335

 cag agc atc ggc acg gtg ccc acc gtg gac ctg gcc tcg cgc tac gag     1056
 Gln Ser Ile Gly Thr Val Pro Thr Val Asp Leu Ala Ser Arg Tyr Glu
             340                 345                 350

 tgt gcc gcg gtg gtg ctg cac tcg ccg ctc acc tcg ggc atg cgc gtc     1104
 Cys Ala Ala Val Val Leu His Ser Pro Leu Thr Ser Gly Met Arg Val
         355                 360                 365

 gcc ttc ccc gac acc aag aag acc tac tgc ttc gac gcc ttc cct aac     1152
 Ala Phe Pro Asp Thr Lys Lys Thr Tyr Cys Phe Asp Ala Phe Pro Asn
     370                 375                 380

 atc gag aag gtg tcc aag atc acg tct ccc gtg ctc atc atc cac ggc     1200
 Ile Glu Lys Val Ser Lys Ile Thr Ser Pro Val Leu Ile Ile His Gly
 385                 390                 395                 400

 acg gag gac gag gtg atc gac ttc tcg cac ggg ctg gcg ctc tac gag     1248
 Thr Glu Asp Glu Val Ile Asp Phe Ser His Gly Leu Ala Leu Tyr Glu
                 405                 410                 415

 cgc tgc ccc aag gcg gtg gag ccg ctg tgg gtg gag ggc gcc ggg cac     1296
 Arg Cys Pro Lys Ala Val Glu Pro Leu Trp Val Glu Gly Ala Gly His
             420                 425                 430

 aac gac atc gag ctc tac agc cag tac ctg gag cgc ctg cgt cgc ttc     1344
 Asn Asp Ile Glu Leu Tyr Ser Gln Tyr Leu Glu Arg Leu Arg Arg Phe
         435                 440                 445

 atc tcc cag gag ctg ccc agc cag cgc gcc tag cggcggcc ccaaccggcc     1395
 Ile Ser Gln Glu Leu Pro Ser Gln Arg Ala 
     450                 455

 ggacctcagc aataaggcgg cccccggacc tcaccccgcg ccggccccca cccaggggct   1455

 gcatgtggac cccccgggcg gcccagggga ccccgccccg acccaggggc tgtggacgat   1515

 gtacaggcaa cagagctacg cactcctttc cttttggaag caagaagaaa atacgtgaaa   1575

 acggaaatta aagatttaaa attttaaaaa aaaaaa                             1611




      <210> 36
      <211> 1333
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (33)..(1019)

      <400> 36
 ctgcatcctt ggaacatgga gggagtggag ga  atg gcc ctt ggg gag gga aag      53
                                      Met Ala Leu Gly Glu Gly Lys
                                        1               5

 tcc cac tgt ggg gag gat agg aaa gag cat aac aat gcc tgc cac cag      101
 Ser His Cys Gly Glu Asp Arg Lys Glu His Asn Asn Ala Cys His Gln
          10                  15                  20

 gag gaa gag gcc cca gat gtc aac cca ttg cat ggt ttg cag gca tcg      149
 Glu Glu Glu Ala Pro Asp Val Asn Pro Leu His Gly Leu Gln Ala Ser
      25                  30                  35

 gga tca ccg gga aag act caa aga atc aag tca cag gca ctg gag gga      197
 Gly Ser Pro Gly Lys Thr Gln Arg Ile Lys Ser Gln Ala Leu Glu Gly
  40                  45                  50                  55

 aca agg ctt tac tca cat agc gaa gag aca aga tca ggc tta ata cga      245
 Thr Arg Leu Tyr Ser His Ser Glu Glu Thr Arg Ser Gly Leu Ile Arg
                  60                  65                  70

 cta ttg cgc ctg cgc cag cgc cgg ctg cga gac tgg ggc cgt ggc tgc      293
 Leu Leu Arg Leu Arg Gln Arg Arg Leu Arg Asp Trp Gly Arg Gly Cys
              75                  80                  85

 tgg tcc cgg gtg atg cta ggc ggc tcc ctg ggc tcc agg ctg ttg cgg      341
 Trp Ser Arg Val Met Leu Gly Gly Ser Leu Gly Ser Arg Leu Leu Arg
          90                  95                 100

 ggt gta ggt ggg agt cac gga cgg ttc ggg gcc cga ggt gtc cgc gaa      389
 Gly Val Gly Gly Ser His Gly Arg Phe Gly Ala Arg Gly Val Arg Glu
     105                 110                 115

 ggt ggc gca gcc atg gcg gca ggg gag agc atg gct cag cgg atg gtc      437
 Gly Gly Ala Ala Met Ala Ala Gly Glu Ser Met Ala Gln Arg Met Val
 120                 125                 130                 135

 tgg gtg gac ctg gag atg aca gga ttg gac att gag aag gac cag att      485
 Trp Val Asp Leu Glu Met Thr Gly Leu Asp Ile Glu Lys Asp Gln Ile
                 140                 145                 150

 att gag atg gcc tgt ctg ata act gac tct gat ctc aac att ttg gct      533
 Ile Glu Met Ala Cys Leu Ile Thr Asp Ser Asp Leu Asn Ile Leu Ala
             155                 160                 165

 gaa ggt cct aac ctg att ata aaa caa cca gat gag ttg ctg gac agc      581
 Glu Gly Pro Asn Leu Ile Ile Lys Gln Pro Asp Glu Leu Leu Asp Ser
         170                 175                 180

 atg tca gat tgg tgt aag gag cat cac ggg aag tct ggc ctt acc aag      629
 Met Ser Asp Trp Cys Lys Glu His His Gly Lys Ser Gly Leu Thr Lys
     185                 190                 195

 gca gtg aag gag agt aca att aca ttg cag cag gca gag tat gaa ttt      677
 Ala Val Lys Glu Ser Thr Ile Thr Leu Gln Gln Ala Glu Tyr Glu Phe
 200                 205                 210                 215

 ctg tcc ttt gta cga cag cag act cct cca ggg ctc tgt cca ctt gca      725
 Leu Ser Phe Val Arg Gln Gln Thr Pro Pro Gly Leu Cys Pro Leu Ala
                 220                 225                 230

 gga aat tca gtt cat gaa gat aag aag ttt ctt gac aaa tac atg ccc      773
 Gly Asn Ser Val His Glu Asp Lys Lys Phe Leu Asp Lys Tyr Met Pro
             235                 240                 245

 cag ttc atg aaa cat ctt cat tat aga ata att gat gtg agc act gtt      821
 Gln Phe Met Lys His Leu His Tyr Arg Ile Ile Asp Val Ser Thr Val
         250                 255                 260

 aaa gaa ctg tgc aga cgc tgg tat cca gaa gaa tat gaa ttt gca cca      869
 Lys Glu Leu Cys Arg Arg Trp Tyr Pro Glu Glu Tyr Glu Phe Ala Pro
     265                 270                 275

 aag aag gct gct tct cat agg gca ctt gat gac att agt gaa agc atc      917
 Lys Lys Ala Ala Ser His Arg Ala Leu Asp Asp Ile Ser Glu Ser Ile
 280                 285                 290                 295

 aaa gag ctt cag ttt tac cga aat aac atc ttc aag aaa aaa ata gat      965
 Lys Glu Leu Gln Phe Tyr Arg Asn Asn Ile Phe Lys Lys Lys Ile Asp
                 300                 305                 310

 gaa aag aag agg aaa att ata gaa aat ggg gaa aat gag aag acc gtg     1013
 Glu Lys Lys Arg Lys Ile Ile Glu Asn Gly Glu Asn Glu Lys Thr Val
             315                 320                 325

 agt tga tgccagttat catgctgcca ctacatcgtt atctggaggc aacttctggt      1069
 Ser 


 ggtttttttt tctcacgctg atggcttggc agagcacctt cggttaactt gcatctccag   1129

 attgattact caagcagaca gcacacgaaa tactattttt ctcctaatat gctgtttcca   1189

 ttatgacaca gcagctcctt tgtaagtacc aggtcatgtc catcccttgg tacatatatg   1249

 catttgcttt taaaccattt cttttgttta aataaataaa taagtaaata aagctagttc   1309

 tattgaaatg caaaaaaaaa aaaa                                          1333




      <210> 37
      <211> 1079
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (2)..(703)

      <400> 37
 a    atg gag gac ttg acg cgt agc gac cgg acc gga att ccc ggg acg      46
      Met Glu Asp Leu Thr Arg Ser Asp Arg Thr Gly Ile Pro Gly Thr
        1               5                  10                  15

 acg att tcg agt gct gag ctc tcc gcg tcg cct ctg tcg ccc gcg cct       94
 Thr Ile Ser Ser Ala Glu Leu Ser Ala Ser Pro Leu Ser Pro Ala Pro
                  20                  25                  30

 ggc cta ccg cgg cac tcc cgg ctg cac gct ctg ctt ggc ctc gcc atg      142
 Gly Leu Pro Arg His Ser Arg Leu His Ala Leu Leu Gly Leu Ala Met
              35                  40                  45

 ccg gtg gac ctc agc aag tgg tcc ggg ccc ttg agc ctg caa gaa gtg      190
 Pro Val Asp Leu Ser Lys Trp Ser Gly Pro Leu Ser Leu Gln Glu Val
          50                  55                  60

 gac gag cag ccg cag cac ccg ctg cat gtc acc tac gcc ggg gcg gcg      238
 Asp Glu Gln Pro Gln His Pro Leu His Val Thr Tyr Ala Gly Ala Ala
      65                  70                  75

 gtg gac gag ctg ggc aaa gtg ctg acg ccc acc cag gtt aag aat aga      286
 Val Asp Glu Leu Gly Lys Val Leu Thr Pro Thr Gln Val Lys Asn Arg
  80                  85                  90                  95

 ccc acc agc att tcg tgg gat ggt ctt gat tca ggg aag ctc tac acc      334
 Pro Thr Ser Ile Ser Trp Asp Gly Leu Asp Ser Gly Lys Leu Tyr Thr
                 100                 105                 110

 ttg gtc ctg aca gac ccg gat gct ccc agc agg aag gat ccc aaa tac      382
 Leu Val Leu Thr Asp Pro Asp Ala Pro Ser Arg Lys Asp Pro Lys Tyr
             115                 120                 125

 aga gaa tgg cat cat ttc ctg gtg gtc aac atg aag ggc aat gac atc      430
 Arg Glu Trp His His Phe Leu Val Val Asn Met Lys Gly Asn Asp Ile
         130                 135                 140

 agc agt ggc aca gtc ctc tcc gat tat gtg ggc tcg ggg cct ccc aag      478
 Ser Ser Gly Thr Val Leu Ser Asp Tyr Val Gly Ser Gly Pro Pro Lys
     145                 150                 155

 ggc aca ggc ctc cac cgc tat gtc tgg ctg gtt tac gag cag gac agg      526
 Gly Thr Gly Leu His Arg Tyr Val Trp Leu Val Tyr Glu Gln Asp Arg
 160                 165                 170                 175

 ccg cta aag tgt gac gag ccc atc ctc agc aac cga tct gga gac cac      574
 Pro Leu Lys Cys Asp Glu Pro Ile Leu Ser Asn Arg Ser Gly Asp His
                 180                 185                 190

 cgt ggc aaa ttc aag gtg gcg tcc ttc cgt aaa aag tat gag ctc agg      622
 Arg Gly Lys Phe Lys Val Ala Ser Phe Arg Lys Lys Tyr Glu Leu Arg
             195                 200                 205

 gcc ccg gtg gct ggc acg tgt tac cag gcc gag tgg gat gac tat gtg      670
 Ala Pro Val Ala Gly Thr Cys Tyr Gln Ala Glu Trp Asp Asp Tyr Val
         210                 215                 220

 ccc aaa ctg tac gag cag ctg tct ggg aag tag ggggttag cttggggacc      721
 Pro Lys Leu Tyr Glu Gln Leu Ser Gly Lys 
     225                 230

 tgaactgtcc tggaggcccc aagccatgtt ccccagttca gtgttgcatg tataatagat    781

 ttctcctctt cctgcccccc ttggcatggg tgagacctga ccagtcagat ggtagttgag    841

 ggtgactttt cctgctgcct ggcctttata attttactca ctcactctga tttatgtttt    901

 gatcaaattt gaacttcatt ttggggggta ttttggtact gtgatggggt catcaaatta    961

 ttaatctgaa aatagcaacc cagaatgtaa aaaagaaaaa actgggggga aaaagaccag   1021

 gtctacagtg atagagcaaa gcatcaaaga atctttaagg aaggtttaaa aaaaaaaa     1079




      <210> 38
      <211> 3373
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1345)..(2475)

      <400> 38
 ctatctaccc attgacaaca ccttcggtct tctcacaaat attgagtaga aacactgcca     60

 actcttcacc tttatctggc tcattcccag agccaggaga agatgtgact tatttggtgg    120

 atgggaaatc ttatccattg gtcccatcaa atccattggt ccacgtttgc ctgtcccaga    180

 tataggtccc tcctttattt ctgtggctat atttgaaaca gaatctttgt cgtcacttgt    240

 agccttctca gctcgttgtt tctgaggaga cactgcccac cagcttctta ggctcttaga    300

 gccagctagc ttcagctctg cttttggtcc gatgaagagg tccccctcca gggctccagc    360

 catcacccgc atgtgcttcg gccgcccgac actgttagga cggataacgt cagcaaggtg    420

 ggcagggagc atggcagagc ttgtgtccag aaaaaccgaa atccaaccat agtcgcccag    480

 agggtacctg gcctccaaac accaggatgt ggctgggggg cacaggttgg aactggggcc    540

 tatggggttc ggggcttgga tccagcagag aacaaagaag agggccatgg ctctgctcat    600

 ctttgcctta gtccataaac catcatggag aagccagtct tctgatggcc cttcagattc    660

 agcagctgtg gactccaggg taccacggaa cctaacggtc cgggctccat ctcttttgct    720

 tctgctgctg gcctttgcaa agaggaaacc tggaggttga agagggtcta aaatctccat    780

 cctgagtttg caaatgctga aagcgtaacc tggttgatca gtacaaatac ccaggggtgg    840

 aagtgccgaa ggagcgtggc ccgaggtgct gggacgcggg aaagacgtct ttctggaccg    900

 gtgctgggac gcgggaaaga cgtcttcctg gaccggtgaa tttccagctc cacagactcc    960

 ggccgcgcgc acaccagccc agctccactt tctgccgccc gcgtcccctt taagacggag   1020

 ccatgacatc atcccagaca ctgcgcagct accttggcaa cgcgcgacca cttttttccg   1080

 gacgacctca attggctggc cagctccgga gccccgcccc ttcgcgcagc agccccgggc   1140

 acctgctgtc aatcgggcca ggtgggagcg atgattggcc gccggccggc cctccagaaa   1200

 gcccgcggct cgcgtaggct gcaggctcgg ggagggaggg cagcgcgccg cgtcggagcc   1260

 gccgccgtcc cggtcctccc gcccgcccgc ccatccggtg cctcctgcag cccgcctgct   1320

 gggcagggcc ggcgcggccc ggcc   atg gag tcc tac gac atc atc gcc aac    1371
                              Met Glu Ser Tyr Asp Ile Ile Ala Asn
                                1               5

 cag cct gtg gtc atc gac aac ggt tcg ggg gtg att aaa gct ggc ttt     1419
 Gln Pro Val Val Ile Asp Asn Gly Ser Gly Val Ile Lys Ala Gly Phe
  10                  15                  20                  25

 gca gga gac cag att ccc aaa tac tgt ttc cca aac tat gtc ggg cgg     1467
 Ala Gly Asp Gln Ile Pro Lys Tyr Cys Phe Pro Asn Tyr Val Gly Arg
                  30                  35                  40

 ccg aag cac atg cgg gtg atg gct gga gcc ctg gag ggg gac ctc ttc     1515
 Pro Lys His Met Arg Val Met Ala Gly Ala Leu Glu Gly Asp Leu Phe
              45                  50                  55

 atc gga cca aaa gca gag gag cac cgg ggg ctg ctg acc atc cgc tac     1563
 Ile Gly Pro Lys Ala Glu Glu His Arg Gly Leu Leu Thr Ile Arg Tyr
          60                  65                  70

 ccc atg gag cac ggc gtg gtg cga gac tgg aac gac atg gaa cgc atc     1611
 Pro Met Glu His Gly Val Val Arg Asp Trp Asn Asp Met Glu Arg Ile
      75                  80                  85

 tgg cag tac gtc tac tcc aag gat cag ctg cag acc ttc tcg gag gag     1659
 Trp Gln Tyr Val Tyr Ser Lys Asp Gln Leu Gln Thr Phe Ser Glu Glu
  90                  95                 100                 105

 cat cct gtg ctc ctc acg gag gcc ccg ctc aac ccg agt aag aac cgg     1707
 His Pro Val Leu Leu Thr Glu Ala Pro Leu Asn Pro Ser Lys Asn Arg
                 110                 115                 120

 gag aag gcg gca gag gtg ttc ttt gag acc ttc aac gtg ccg gcc ctg     1755
 Glu Lys Ala Ala Glu Val Phe Phe Glu Thr Phe Asn Val Pro Ala Leu
             125                 130                 135

 ttc atc tcc atg cag gct gtg ctc agt ctg tac gca aca gga cgc acg     1803
 Phe Ile Ser Met Gln Ala Val Leu Ser Leu Tyr Ala Thr Gly Arg Thr
         140                 145                 150

 aca gga gtg gtt cta gac tca ggg gac ggg gtc act cat gct gtg ccc     1851
 Thr Gly Val Val Leu Asp Ser Gly Asp Gly Val Thr His Ala Val Pro
     155                 160                 165

 atc tat gag ggc ttt gcc atg cct cac tcc atc atg cgg gtg gac att     1899
 Ile Tyr Glu Gly Phe Ala Met Pro His Ser Ile Met Arg Val Asp Ile
 170                 175                 180                 185

 gcc ggc cgc gac gtc tcc cgc tac ctc cga ctc ctg ctg cgc aag gaa     1947
 Ala Gly Arg Asp Val Ser Arg Tyr Leu Arg Leu Leu Leu Arg Lys Glu
                 190                 195                 200

 ggg gtt gac ttc cat acc tcg gct gag ttt gag gtt gtc cgg aca atc     1995
 Gly Val Asp Phe His Thr Ser Ala Glu Phe Glu Val Val Arg Thr Ile
             205                 210                 215

 aaa gag cga gcg tgc tac ctg tcc atc aac cca cag aag gat gag gct     2043
 Lys Glu Arg Ala Cys Tyr Leu Ser Ile Asn Pro Gln Lys Asp Glu Ala
         220                 225                 230

 ctg gag acg gag aag gtg cag tac acg ttg cca gac ggc agc acg ctt     2091
 Leu Glu Thr Glu Lys Val Gln Tyr Thr Leu Pro Asp Gly Ser Thr Leu
     235                 240                 245

 gat gtg ggg cct gca cga ttc cgg gcc ccc gag ctg ctg ttc cag ccg     2139
 Asp Val Gly Pro Ala Arg Phe Arg Ala Pro Glu Leu Leu Phe Gln Pro
 250                 255                 260                 265

 gac ctt gtg ggg gat gag agt gag ggg ctc cat gag gtg gtg gcc ttc     2187
 Asp Leu Val Gly Asp Glu Ser Glu Gly Leu His Glu Val Val Ala Phe
                 270                 275                 280

 gcc ata cac aag tcc gac atg gac ctg cgc cgg acg ctg ttc gcc aac     2235
 Ala Ile His Lys Ser Asp Met Asp Leu Arg Arg Thr Leu Phe Ala Asn
             285                 290                 295

 atc gtg ctc tca ggt ggc tca acg ctt ttc aaa ggc ttc gga gac cga     2283
 Ile Val Leu Ser Gly Gly Ser Thr Leu Phe Lys Gly Phe Gly Asp Arg
         300                 305                 310

 tta ctc agt gaa gtg aag aag ctt gcc cca aag gat atc aaa atc aag     2331
 Leu Leu Ser Glu Val Lys Lys Leu Ala Pro Lys Asp Ile Lys Ile Lys
     315                 320                 325

 atc tca gcc ccg cag gaa cgg ctg tac tcc aca tgg att ggc ggc tcc     2379
 Ile Ser Ala Pro Gln Glu Arg Leu Tyr Ser Thr Trp Ile Gly Gly Ser
 330                 335                 340                 345

 atc ctg gcc tcg ctg gac act ttt aag aag atg tgg gtg tcc aaa aag     2427
 Ile Leu Ala Ser Leu Asp Thr Phe Lys Lys Met Trp Val Ser Lys Lys
                 350                 355                 360

 gag tat gaa gag gat ggc tcc cgt gct att cat cgc aaa act ttc tag     2475
 Glu Tyr Glu Glu Asp Gly Ser Arg Ala Ile His Arg Lys Thr Phe 
             365                 370                 375

 tgcccaagga gggcggggca tgttgggaaa gggggaggga ggggagacag agcctttaac   2535

 cctttttggt cttggctcgt atactaggct tagggtcccc tgcatgccct gaacccctgg   2595

 gtgggtggca cagcagtgcc cccctgcagc cttcccctct acacaggaca tgcacacaca   2655

 agtaacattg agctgcatgg acaggagcct tgagctggcg tgtgggaatt gagcgccatg   2715

 tcaggctgtt gtgggtatcc ccctggcagg gccagctagg cctgtggttc cctgctccga   2775

 ctctcagggc tgcctccctg agctccaggg ccagaatgcc tggatgcctg ggtagccagt   2835

 ttggggagtg ggctgcaagg ggcagccagc agctcccact ggtgtgtcac tgcatccatt   2895

 gccacctcct gttcgtgacc tgacagggtg acacagcccc tttcacactc tgtcctccta   2955

 tcttcctggg tagatgccct ggtgtagggc tgagtactga atggtcttcc atccccagca   3015

 agggggtgca gcccagggtc aggcccttca gagccagggc agaggacgca cggtggctag   3075

 agccgctgca ctatcctttt cagagcactt catccacttg ctcctccctc taccctcggc   3135

 accctgggtg ggaaagggtt gatgctcatc atttattgag gggaagccac ttaataagga   3195

 gtcagaccta aaagggggtg ggggacattt tcttacctca cccaagaaag aggtcgtcac   3255

 ttttgctgtg gccagggccc cacctccctc tctcagatat gtacaataat ttaacacggt   3315

 tgcctgaaaa aaacttttgt aaatcattat agtaataatt atggacaaaa aaaaaaaa     3373




      <210> 39
      <211> 2125
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (52)..(1509)

      <400> 39
 taagcttgcg gccgcgggct agcaagctcc cggagccggc ggcgcaccac c atg acc      57
                                                          Met Thr
                                                            1

 cag tcg gtg gtc gta cag gtc ggc cag tgc gga aac cag atc ggc tgc      105
 Gln Ser Val Val Val Gln Val Gly Gln Cys Gly Asn Gln Ile Gly Cys
           5                  10                  15

 tgc ttc tgg gac ctg gca cta agg gag cac gcc gcg gtc aac cag aaa      153
 Cys Phe Trp Asp Leu Ala Leu Arg Glu His Ala Ala Val Asn Gln Lys
      20                  25                  30

 gga att tat gat gag gca ata agc agc ttc ttt aga aat gtg gac acc      201
 Gly Ile Tyr Asp Glu Ala Ile Ser Ser Phe Phe Arg Asn Val Asp Thr
  35                  40                  45                  50

 aga gtg gtt ggt gat ggt gga agt att tcc aag gga aaa ata tgt tct      249
 Arg Val Val Gly Asp Gly Gly Ser Ile Ser Lys Gly Lys Ile Cys Ser
                  55                  60                  65

 tta aaa gca cga gca gtc ttg att gat atg gaa gaa ggg gta gtg aat      297
 Leu Lys Ala Arg Ala Val Leu Ile Asp Met Glu Glu Gly Val Val Asn
              70                  75                  80

 gaa att ctg cag gga cca ctg aga gat gta ttt gat acg aaa cag ctc      345
 Glu Ile Leu Gln Gly Pro Leu Arg Asp Val Phe Asp Thr Lys Gln Leu
          85                  90                  95

 atc act gat att tct ggc tca gga aat aat tgg gcc gtg ggt cac aaa      393
 Ile Thr Asp Ile Ser Gly Ser Gly Asn Asn Trp Ala Val Gly His Lys
     100                 105                 110

 gtt ttc ggc agt ctt tac caa gac cag att tta gag aaa ttc aga aag      441
 Val Phe Gly Ser Leu Tyr Gln Asp Gln Ile Leu Glu Lys Phe Arg Lys
 115                 120                 125                 130

 tcg gca gag cac tgt gat tgc ttg cag tgt ttc ttt ata ata cat tcc      489
 Ser Ala Glu His Cys Asp Cys Leu Gln Cys Phe Phe Ile Ile His Ser
                 135                 140                 145

 atg gga gga gga aca gga tct gga ctt ggc aca ttt ctt tta aag gtg      537
 Met Gly Gly Gly Thr Gly Ser Gly Leu Gly Thr Phe Leu Leu Lys Val
             150                 155                 160

 ctt gaa gac gaa ttc cca gaa gta tac aga ttt gtg act tcc att tat      585
 Leu Glu Asp Glu Phe Pro Glu Val Tyr Arg Phe Val Thr Ser Ile Tyr
         165                 170                 175

 cct tct ggt gag gat gat gtc ata acc tca cct tat aat agc atc ttg      633
 Pro Ser Gly Glu Asp Asp Val Ile Thr Ser Pro Tyr Asn Ser Ile Leu
     180                 185                 190

 gca atg aag gaa ctt aat gag cat gca gac tgt gta ttg ccc att gac      681
 Ala Met Lys Glu Leu Asn Glu His Ala Asp Cys Val Leu Pro Ile Asp
 195                 200                 205                 210

 aat caa tct tta ttt gac atc att agc aaa atc gac ctc atg gtg aat      729
 Asn Gln Ser Leu Phe Asp Ile Ile Ser Lys Ile Asp Leu Met Val Asn
                 215                 220                 225

 tct gga aag ttg ggt aca act gtg aag cca aag agt ctg gtt act tca      777
 Ser Gly Lys Leu Gly Thr Thr Val Lys Pro Lys Ser Leu Val Thr Ser
             230                 235                 240

 agt tct ggg gct tta aaa aag cag cat aag aag ccc ttt gat gca atg      825
 Ser Ser Gly Ala Leu Lys Lys Gln His Lys Lys Pro Phe Asp Ala Met
         245                 250                 255

 aat aac att gtg gca aat ttg ctc ctc aac cta acg agc tct gca aga      873
 Asn Asn Ile Val Ala Asn Leu Leu Leu Asn Leu Thr Ser Ser Ala Arg
     260                 265                 270

 ttt gaa ggg tcc ctt aat atg gac ctt aat gaa atc agc atg aat tta      921
 Phe Glu Gly Ser Leu Asn Met Asp Leu Asn Glu Ile Ser Met Asn Leu
 275                 280                 285                 290

 gtt cct ttt cct caa ctt cat tat ctc gtg tca agc cta aca cct ctg      969
 Val Pro Phe Pro Gln Leu His Tyr Leu Val Ser Ser Leu Thr Pro Leu
                 295                 300                 305

 tat aca ctg aca gat gtt aac att cct cct aga aga ttg gat cag atg     1017
 Tyr Thr Leu Thr Asp Val Asn Ile Pro Pro Arg Arg Leu Asp Gln Met
             310                 315                 320

 ttt tca gat gcc ttt agt aaa gat cac cag ctg ctt cgg gca gac ccc     1065
 Phe Ser Asp Ala Phe Ser Lys Asp His Gln Leu Leu Arg Ala Asp Pro
         325                 330                 335

 aaa cac agt ctt tac ctc gcc tgt gca ctc atg gtt aga gga aat gta     1113
 Lys His Ser Leu Tyr Leu Ala Cys Ala Leu Met Val Arg Gly Asn Val
     340                 345                 350

 caa att tca gat ctt cgt aga aat att gaa aga tta aaa cca tct cta     1161
 Gln Ile Ser Asp Leu Arg Arg Asn Ile Glu Arg Leu Lys Pro Ser Leu
 355                 360                 365                 370

 caa ttt gtc tcc tgg aat caa gaa ggc tgg aag acc agc ctg tgt tcc     1209
 Gln Phe Val Ser Trp Asn Gln Glu Gly Trp Lys Thr Ser Leu Cys Ser
                 375                 380                 385

 gta cct cct gtg ggc cat tct cat tcg tta tta gct tta gca aat aac     1257
 Val Pro Pro Val Gly His Ser His Ser Leu Leu Ala Leu Ala Asn Asn
             390                 395                 400

 aca tgt gtg aag ccc acc ttc atg gaa ctg aaa gag aga ttc atg agg     1305
 Thr Cys Val Lys Pro Thr Phe Met Glu Leu Lys Glu Arg Phe Met Arg
         405                 410                 415

 ctc tac aag aaa aag gct cac ctt cat cac tat cta caa gtt gaa ggg     1353
 Leu Tyr Lys Lys Lys Ala His Leu His His Tyr Leu Gln Val Glu Gly
     420                 425                 430

 atg gaa gaa agc tgt ttc aca gaa gct gtg tca tct tta tca gca ctc     1401
 Met Glu Glu Ser Cys Phe Thr Glu Ala Val Ser Ser Leu Ser Ala Leu
 435                 440                 445                 450

 ata cag gaa tat gac caa ctg gac gcc aca aaa aaa cat gcc tgt gca     1449
 Ile Gln Glu Tyr Asp Gln Leu Asp Ala Thr Lys Lys His Ala Cys Ala
                 455                 460                 465

 gga ttt acc cag act aag cat agc tat gtg aaa aag aaa ccc tca aaa     1497
 Gly Phe Thr Gln Thr Lys His Ser Tyr Val Lys Lys Lys Pro Ser Lys
             470                 475                 480

 ata ctt tct taa ttt cacattgttt tttctgacct ttctgtttca acatttttgt     1552
 Ile Leu Ser 
         485

 aatttggaaa ctccagtttt ttcatattat cgggaaatat ttttgtctaa aagagtgatt   1612

 tctgtttaat cgcaatttgt tggtaatacc aatgtgtgaa attagtgaaa tcttagtacc   1672

 ttaacttcaa acatttctct tcagaaaagt tcccttttct aaaattgaga taacatagtt   1732

 cttgaatatt ttgctgtatt tatagcctca tatttaggca tttatgcact gatgtgtctt   1792

 caataaaaat cttgtacaga tatattttta taattattta taatttatat tttgatattc   1852

 tatttaagtt atcctgattc tttaaaagta gttattggga gtagaagaac acaatataaa   1912

 tatttccgtg taatagccac caacttttca ggcataggtt ttattacaac tgttaaggag   1972

 gttttgcttc ttctttagat aacaacttgt ttgcccaaaa gaatcctaat ttgtacactt   2032

 aacatgtatt tgtattaaac tttttaaata attgctttct tatcaaacca attgatttta   2092

 taataaatgt ctatattttt caaaaaaaaa aaa                                2125




      <210> 40
      <211> 2165
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (8)..(1726)

      <400> 40
 accggcc  atg gcg gcc ccc cgc ccg tct ccc gcg atc tcc gtt tcg gtc      49
          Met Ala Ala Pro Arg Pro Ser Pro Ala Ile Ser Val Ser Val
            1               5                  10

 tcg gct ccg gct ttt tac gcc ccg cag aag aag ttc ggc cct gtg gtg       97
 Ser Ala Pro Ala Phe Tyr Ala Pro Gln Lys Lys Phe Gly Pro Val Val
  15                  20                  25                  30

 gcc cca aag ccc aaa gtg aat ccc ttc cgg ccc ggg gac agc gag cct      145
 Ala Pro Lys Pro Lys Val Asn Pro Phe Arg Pro Gly Asp Ser Glu Pro
                  35                  40                  45

 ccc ccg gca ccc ggg gcc cag cgc gca cag atg ggc cgg gtg ggc gag      193
 Pro Pro Ala Pro Gly Ala Gln Arg Ala Gln Met Gly Arg Val Gly Glu
              50                  55                  60

 att ccc ccg ccg ccc ccg gaa gac ttt ccc ctg cct cca cct ccc ctt      241
 Ile Pro Pro Pro Pro Pro Glu Asp Phe Pro Leu Pro Pro Pro Pro Leu
          65                  70                  75

 gct ggg gat ggc gac gat gca gag ggt gct ctg gga ggt gcc ttc ccg      289
 Ala Gly Asp Gly Asp Asp Ala Glu Gly Ala Leu Gly Gly Ala Phe Pro
      80                  85                  90

 ccg ccc cct ccc ccg atc gag gaa tca ttt ccc cct gcg cct ctg gag      337
 Pro Pro Pro Pro Pro Ile Glu Glu Ser Phe Pro Pro Ala Pro Leu Glu
  95                 100                 105                 110

 gag gag atc ttc cct tcc ccg ccg cct cct ccg gag gag gag gga ggg      385
 Glu Glu Ile Phe Pro Ser Pro Pro Pro Pro Pro Glu Glu Glu Gly Gly
                 115                 120                 125

 cct gag gcc ccc ata ccg ccc cca cca cag ccc agg gag aag gtg agc      433
 Pro Glu Ala Pro Ile Pro Pro Pro Pro Gln Pro Arg Glu Lys Val Ser
             130                 135                 140

 agt att gat ttg gag atc gac tct ctg tcc tca ctg ctg gat gac atg      481
 Ser Ile Asp Leu Glu Ile Asp Ser Leu Ser Ser Leu Leu Asp Asp Met
         145                 150                 155

 acc aag aat gat cct ttc aaa gcc cgg gtg tca tct gga tat gtg ccc      529
 Thr Lys Asn Asp Pro Phe Lys Ala Arg Val Ser Ser Gly Tyr Val Pro
     160                 165                 170

 cca cca gtg gcc act cca ttc agt tcc aag tcc agt acc aag cct gca      577
 Pro Pro Val Ala Thr Pro Phe Ser Ser Lys Ser Ser Thr Lys Pro Ala
 175                 180                 185                 190

 gcc ggg ggc aca gca ccc ctg cct cct tgg aag tcc cct tcc agc tcc      625
 Ala Gly Gly Thr Ala Pro Leu Pro Pro Trp Lys Ser Pro Ser Ser Ser
                 195                 200                 205

 cag cct ctg ccc cag gtt ccg gct ccg gct cag agc cag aca cag ttc      673
 Gln Pro Leu Pro Gln Val Pro Ala Pro Ala Gln Ser Gln Thr Gln Phe
             210                 215                 220

 cat gtt cag ccc cag ccc cag ccc aag cct cag gtc caa ctc cat gtc      721
 His Val Gln Pro Gln Pro Gln Pro Lys Pro Gln Val Gln Leu His Val
         225                 230                 235

 cag tcc cag acc cag cct gtg tct ttg gct aac acc cag ccc cga ggg      769
 Gln Ser Gln Thr Gln Pro Val Ser Leu Ala Asn Thr Gln Pro Arg Gly
     240                 245                 250

 ccc cca gcc tca tct ccg gct cca gcc cct aag ttt tct cca gtg act      817
 Pro Pro Ala Ser Ser Pro Ala Pro Ala Pro Lys Phe Ser Pro Val Thr
 255                 260                 265                 270

 cct aag ttt act cct gtg gct tcc aag ttc agt cct gga gcc cca ggt      865
 Pro Lys Phe Thr Pro Val Ala Ser Lys Phe Ser Pro Gly Ala Pro Gly
                 275                 280                 285

 gga tct ggg tca caa cca aat caa aaa ttg ggg cac ccc gaa gct ctt      913
 Gly Ser Gly Ser Gln Pro Asn Gln Lys Leu Gly His Pro Glu Ala Leu
             290                 295                 300

 tct gct ggc aca ggc tcc cct caa cct ccc agc ttc acc tat gcc cag      961
 Ser Ala Gly Thr Gly Ser Pro Gln Pro Pro Ser Phe Thr Tyr Ala Gln
         305                 310                 315

 cag agg gag aag ccc cga gtg cag gag aag cag cac ccc gtg ccc cca     1009
 Gln Arg Glu Lys Pro Arg Val Gln Glu Lys Gln His Pro Val Pro Pro
     320                 325                 330

 ccg gct cag aac caa aac cag gtg cgc tcc cct ggg gcc cca ggg ccc     1057
 Pro Ala Gln Asn Gln Asn Gln Val Arg Ser Pro Gly Ala Pro Gly Pro
 335                 340                 345                 350

 ctg act ctg aag gag gtg gag gag ctg gag cag ctg acc cag cag cta     1105
 Leu Thr Leu Lys Glu Val Glu Glu Leu Glu Gln Leu Thr Gln Gln Leu
                 355                 360                 365

 atg cag gac atg gag cat cct cag agg cag aat gtg gct gtc aac gaa     1153
 Met Gln Asp Met Glu His Pro Gln Arg Gln Asn Val Ala Val Asn Glu
             370                 375                 380

 ctc tgc ggc cga tgc cat caa ccc ctg gcc cgg gcg cag cca gcc gtc     1201
 Leu Cys Gly Arg Cys His Gln Pro Leu Ala Arg Ala Gln Pro Ala Val
         385                 390                 395

 cgc gct cta ggg cag ctg ttc cac atc gcc tgc ttc acc tgc cac cag     1249
 Arg Ala Leu Gly Gln Leu Phe His Ile Ala Cys Phe Thr Cys His Gln
     400                 405                 410

 tgt gcg cag cag ctc cag ggc cag cag ttc tac agt ctg gag ggg gcg     1297
 Cys Ala Gln Gln Leu Gln Gly Gln Gln Phe Tyr Ser Leu Glu Gly Ala
 415                 420                 425                 430

 ccg tac tgc gag ggc tgt tac act gac acc ctg gag aag tgt aac acc     1345
 Pro Tyr Cys Glu Gly Cys Tyr Thr Asp Thr Leu Glu Lys Cys Asn Thr
                 435                 440                 445

 tgc ggg gag ccc atc act gac cgc atg ctg agg gcc acg ggc aag gcc     1393
 Cys Gly Glu Pro Ile Thr Asp Arg Met Leu Arg Ala Thr Gly Lys Ala
             450                 455                 460

 tat cac ccg cac tgc ttc acc tgt gtg gtc tgc gcc cgc ccc ctg gag     1441
 Tyr His Pro His Cys Phe Thr Cys Val Val Cys Ala Arg Pro Leu Glu
         465                 470                 475

 ggc acc tcc ttc atc gtg gac cag gcc aac cgg ccc cac tgt gtc ccc     1489
 Gly Thr Ser Phe Ile Val Asp Gln Ala Asn Arg Pro His Cys Val Pro
     480                 485                 490

 gac tac cac aag cag tac gcc ccg agg tgc tcc gtc tgc tct gag ccc     1537
 Asp Tyr His Lys Gln Tyr Ala Pro Arg Cys Ser Val Cys Ser Glu Pro
 495                 500                 505                 510

 atc atg cct gag cct ggc cga gat gag act gtg cga gtg gtc gcc ctg     1585
 Ile Met Pro Glu Pro Gly Arg Asp Glu Thr Val Arg Val Val Ala Leu
                 515                 520                 525

 gac aag aac ttc cac atg aag tgt tac aag tgt gag gac tgc ggg aag     1633
 Asp Lys Asn Phe His Met Lys Cys Tyr Lys Cys Glu Asp Cys Gly Lys
             530                 535                 540

 ccc ctg tcg att gag gca gat gac aat ggc tgc ttc ccc ctg gac ggt     1681
 Pro Leu Ser Ile Glu Ala Asp Asp Asn Gly Cys Phe Pro Leu Asp Gly
         545                 550                 555

 cac gtg ctc tgt cgg aag tgc cac act gct aga gcc cag acc tga gtg     1729
 His Val Leu Cys Arg Lys Cys His Thr Ala Arg Ala Gln Thr 
     560                 565                 570

 aggacaggcc ctcttcagac cgcagtccat gccccattgt ggaccaccca cactgagacc   1789

 accctccccc acctcagtta ttgttttgat gtctagcccc tcccatttcc aacccctccc   1849

 tagcatccca ggtgccctga cccaggaccc aacatggtct agggatgcag gatccccgcc   1909

 ctggggtctg gtcctcgccc atcctgcagg gattgcccac cgtcttccag acaccccacc   1969

 tgaggggggc accaggttta gtgctgctgc tttcactgct gcacccgcgc cctcggccgg   2029

 ccccccgagc agcctttgta ctctgcttgc ggagggctgg gagaccctcc aggacattcc   2089

 caccctcccc catgctgcca agttgtagct atagctacaa ataaaaaaaa accttgtttt   2149

 ccagaaaaaa aaaaaa                                                   2165




      <210> 41
      <211> 2273
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (141)..(1064)

      <400> 41
 ctctgccgta ccggtccgga attcccgggt cgacgatttc gtgcgactct cacaccctga     60

 gctccggtgc tcctttccta actccactgg ctgcggcatc tgtgggaaaa gtgtggctgg    120

 gtcttcgagg agccgcacca    atg gct tcc gtg ctg tcc tac gaa agc ctg     170
                          Met Ala Ser Val Leu Ser Tyr Glu Ser Leu
                            1               5                  10

 gtc cac gcc gtg gcc gga gcc gtg gga agc gtg aca gca atg aca gtg      218
 Val His Ala Val Ala Gly Ala Val Gly Ser Val Thr Ala Met Thr Val
                  15                  20                  25

 ttt ttt ccc ctg gat aca gct aga ctt cga ctt cag gtt gat gag aaa      266
 Phe Phe Pro Leu Asp Thr Ala Arg Leu Arg Leu Gln Val Asp Glu Lys
              30                  35                  40

 aga aaa tcc aaa act aca cac atg gtg ctc ctg gag atc att aaa gaa      314
 Arg Lys Ser Lys Thr Thr His Met Val Leu Leu Glu Ile Ile Lys Glu
          45                  50                  55

 gaa gga ctc ctg gca cca tat cga ggg tgg ttt cca gtg att tcc agt      362
 Glu Gly Leu Leu Ala Pro Tyr Arg Gly Trp Phe Pro Val Ile Ser Ser
      60                  65                  70

 ctc tgc tgc tcc aat ttt gtc tat ttc tac act ttt aat agc ctc aaa      410
 Leu Cys Cys Ser Asn Phe Val Tyr Phe Tyr Thr Phe Asn Ser Leu Lys
  75                  80                  85                  90

 gca ctc tgg gtc aaa ggt caa cat tct acc act gga aaa gat ctg gta      458
 Ala Leu Trp Val Lys Gly Gln His Ser Thr Thr Gly Lys Asp Leu Val
                  95                 100                 105

 gtt ggg ttt gtt gca gga gtg gtt aat gtg ttg cta aca act cca ctc      506
 Val Gly Phe Val Ala Gly Val Val Asn Val Leu Leu Thr Thr Pro Leu
             110                 115                 120

 tgg gtg gta aac acc aga ctg aag ctt caa gga gca aaa ttt agg aat      554
 Trp Val Val Asn Thr Arg Leu Lys Leu Gln Gly Ala Lys Phe Arg Asn
         125                 130                 135

 gaa gac att gta cca aca aac tac aaa ggt atc att gat gct ttt cat      602
 Glu Asp Ile Val Pro Thr Asn Tyr Lys Gly Ile Ile Asp Ala Phe His
     140                 145                 150

 cag atc att cgc gat gaa gga atc tcg gct tta tgg aat ggc aca ttt      650
 Gln Ile Ile Arg Asp Glu Gly Ile Ser Ala Leu Trp Asn Gly Thr Phe
 155                 160                 165                 170

 ccc tca ttg ctg ttg gtc ttc aat cct gcc atc cag ttc atg ttt tat      698
 Pro Ser Leu Leu Leu Val Phe Asn Pro Ala Ile Gln Phe Met Phe Tyr
                 175                 180                 185

 gaa ggt tta aaa cgg cag ctt tta aag aaa cgg atg aag ctt tct tcc      746
 Glu Gly Leu Lys Arg Gln Leu Leu Lys Lys Arg Met Lys Leu Ser Ser
             190                 195                 200

 ttg gat gtg ttc atc att ggg gca gta gcc aaa gcg att gcc acc acg      794
 Leu Asp Val Phe Ile Ile Gly Ala Val Ala Lys Ala Ile Ala Thr Thr
         205                 210                 215

 gtg acc tat ccc ctg cag acg gta cag tca att ctg agg ttt ggg cgt      842
 Val Thr Tyr Pro Leu Gln Thr Val Gln Ser Ile Leu Arg Phe Gly Arg
     220                 225                 230

 cat aga cta aac cca gaa aac aga aca ttg gga agt ctt cgg aat att      890
 His Arg Leu Asn Pro Glu Asn Arg Thr Leu Gly Ser Leu Arg Asn Ile
 235                 240                 245                 250

 ctc tat ctt ctt cac caa cga gta aga cgt ttt gga ata atg gga ctc      938
 Leu Tyr Leu Leu His Gln Arg Val Arg Arg Phe Gly Ile Met Gly Leu
                 255                 260                 265

 tac aaa ggc ctt gaa gcc aaa ctg ctg cag aca gtc ctc act gct gct      986
 Tyr Lys Gly Leu Glu Ala Lys Leu Leu Gln Thr Val Leu Thr Ala Ala
             270                 275                 280

 ctc atg ttc ctt gtt tat gag aaa ctg aca gct gcc acc ttc aca gtt     1034
 Leu Met Phe Leu Val Tyr Glu Lys Leu Thr Ala Ala Thr Phe Thr Val
         285                 290                 295

 atg ggg ctg aag cgt gca cac caa cac tga g acgccttccc atgaaaaatt     1085
 Met Gly Leu Lys Arg Ala His Gln His 
     300                 305

 ccgaagatgc tcaagaggga ggtttcctcc tgagtgaaga gaagtgattc tcccttgact   1145

 ctggctcctg ccaccacaaa tgttaccctc attggcttga aaagcatcca agggtgcaca   1205

 gggagtatgg ccaactggac ctgttgtcac cttaattgtc atgctggctg gttggatttt   1265

 ggggtggcag ttggactaat gtgaaaaaaa cattgctgaa aacctaaaaa tgaaagtttg   1325

 tgagtgttta ttggttttct taagagaaat ggactatttt gctctcatgt gtaatgtttt   1385

 ctatttaaat ctttcttaaa tataccagct gttctctttc cctgaactct cccccaggtt   1445

 ctaggacaaa tttaataaca tgtaattctc ctcaaatact tttgtatgtc tcagtgttgg   1505

 tgttttcctc cctaaaacta acattagggc tgtgccacgg gcatgacttt atttttgttg   1565

 ggcttttttt tccctgctta aggagaggtg tcttttttgg atatgagcta tttattttgt   1625

 gaaatgaaaa ttgttcaccc aaatgattct cttataaact atttgtaaat gtcacttatt   1685

 cattagtgtt tgacataatt tttagaatat ttattttgaa tcaatccttt cattacgaaa   1745

 gacttgaagt tttgtgtcca ttcttacaag ccctggtcag tcaagtccca ataaatggtc   1805

 agcacaaaaa agatattctt gaaaattgct ctttattaag gtattacgtt gagtttgcaa   1865

 ccagatggga aaaatcacaa aaatgagaag gggagcagat atcttgttga ggtctggata   1925

 ttatctccct ttataaactt ggtgtaggcc gtatattttg aaaataaaca tctggttgag   1985

 gttatttcat ttggaaacct tccttagagt cctgttgctc agtgtggtcc atcagacggt   2045

 agtactgcca caagctgaga gcttgctggg cacgcaaccc agagtttctg aatcctgttc   2105

 cgtattttaa cattcccagg tgattcacag ccacattaaa gttcaggaga ccataggacc   2165

 cctgacccat gagaagaagt gattggtttc gattatagac atcaagataa agatttttct   2225

 caaaggaaag agattaatgt attaaaacaa cctctgaaaa aaaaaaaa                2273




      <210> 42
      <211> 5885
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (152)..(2968)

      <400> 42
 actcgtctac attctttttg taaagtgatg cgaatatttg taaagtctaa gcaaattggt     60

 tgagttcctg accataaatg ctttatgata attttttagg tatatttgat tttaaaagtt    120

 ttatgcttgc ttttaaactt aacttcgacc a   atg act tcc ttt ttc tca gag     172
                                      Met Thr Ser Phe Phe Ser Glu
                                        1               5

 tct cca cag cct att ggc tca ctt gga cat gat gct gac ttg agg cgg      220
 Ser Pro Gln Pro Ile Gly Ser Leu Gly His Asp Ala Asp Leu Arg Arg
          10                  15                  20

 cag cag cag gat acc tgt aac tcc ggc att gct gac atc cat agg ctg      268
 Gln Gln Gln Asp Thr Cys Asn Ser Gly Ile Ala Asp Ile His Arg Leu
      25                  30                  35

 ttt aat tgg tta tca gaa aca cta gca aat gcg cgc cat tct gat gca      316
 Phe Asn Trp Leu Ser Glu Thr Leu Ala Asn Ala Arg His Ser Asp Ala
  40                  45                  50                  55

 tct ctg aca gac aca gtc aac aaa gcc tta gga ttg agc act gat gat      364
 Ser Leu Thr Asp Thr Val Asn Lys Ala Leu Gly Leu Ser Thr Asp Asp
                  60                  65                  70

 gcc tat gaa gag ctg agg caa aaa cat gag tat gag ttg aac tct acc      412
 Ala Tyr Glu Glu Leu Arg Gln Lys His Glu Tyr Glu Leu Asn Ser Thr
              75                  80                  85

 cca gat aag aaa gac tat gag cag cct act tgt gca aaa gtt gaa aat      460
 Pro Asp Lys Lys Asp Tyr Glu Gln Pro Thr Cys Ala Lys Val Glu Asn
          90                  95                 100

 gca cag ttt aag ggt act cag agc tta tta cta gaa gtt gat gca aca      508
 Ala Gln Phe Lys Gly Thr Gln Ser Leu Leu Leu Glu Val Asp Ala Thr
     105                 110                 115

 tct aag tat tct gtt gct att tct acc agc gaa gtg ggc act gac cat      556
 Ser Lys Tyr Ser Val Ala Ile Ser Thr Ser Glu Val Gly Thr Asp His
 120                 125                 130                 135

 aag cta cat ttg aaa gaa gat cca aat tta att agc gtg aat aat ttt      604
 Lys Leu His Leu Lys Glu Asp Pro Asn Leu Ile Ser Val Asn Asn Phe
                 140                 145                 150

 gaa gat tgc agt ttg tgt ccc agt gtt ccc att gaa cat gga ttt cgt      652
 Glu Asp Cys Ser Leu Cys Pro Ser Val Pro Ile Glu His Gly Phe Arg
             155                 160                 165

 aga caa cag tct aag tca aat aat gtt gaa gag act gaa ata cat tgg      700
 Arg Gln Gln Ser Lys Ser Asn Asn Val Glu Glu Thr Glu Ile His Trp
         170                 175                 180

 aaa ctg att cca att aca gga ggg aat gca aga agc cca gaa gac cag      748
 Lys Leu Ile Pro Ile Thr Gly Gly Asn Ala Arg Ser Pro Glu Asp Gln
     185                 190                 195

 ctg ggg aaa cat ggt gag aaa caa aca cca ggt atg aaa tca cca gaa      796
 Leu Gly Lys His Gly Glu Lys Gln Thr Pro Gly Met Lys Ser Pro Glu
 200                 205                 210                 215

 gaa caa ctg gtg tgt gtg cca cca cag gag gcc ttt cct aac gac ccc      844
 Glu Gln Leu Val Cys Val Pro Pro Gln Glu Ala Phe Pro Asn Asp Pro
                 220                 225                 230

 cgg gta ata aat aga cag aga agt tct gat tac cag ttt cca tcc tct      892
 Arg Val Ile Asn Arg Gln Arg Ser Ser Asp Tyr Gln Phe Pro Ser Ser
             235                 240                 245

 cca ttt aca gac aca cta aag ggc acc act gag gat gac gtg ttg aca      940
 Pro Phe Thr Asp Thr Leu Lys Gly Thr Thr Glu Asp Asp Val Leu Thr
         250                 255                 260

 ggt cag gtg gag gag cag tgt gtg cca gca gca gag gca gag ccg cct      988
 Gly Gln Val Glu Glu Gln Cys Val Pro Ala Ala Glu Ala Glu Pro Pro
     265                 270                 275

 gca gtg agc gaa acc aca gag agg aca gtg tta gga gag tac aat ctc     1036
 Ala Val Ser Glu Thr Thr Glu Arg Thr Val Leu Gly Glu Tyr Asn Leu
 280                 285                 290                 295

 ttt tct agg aag ata gaa gag att ttg aag caa aag aat gtt tca tat     1084
 Phe Ser Arg Lys Ile Glu Glu Ile Leu Lys Gln Lys Asn Val Ser Tyr
                 300                 305                 310

 gtc agt aga gtt tcc aca cct atc ttt tca aca caa gag aag atg aaa     1132
 Val Ser Arg Val Ser Thr Pro Ile Phe Ser Thr Gln Glu Lys Met Lys
             315                 320                 325

 cgg ctt tcc gag ttc ata tat tct aag act tcc aaa gct ggt gtg cag     1180
 Arg Leu Ser Glu Phe Ile Tyr Ser Lys Thr Ser Lys Ala Gly Val Gln
         330                 335                 340

 gag ttt gta gat ggt ttg cat gag aag cta aat act att att att aaa     1228
 Glu Phe Val Asp Gly Leu His Glu Lys Leu Asn Thr Ile Ile Ile Lys
     345                 350                 355

 gca tca gcc aag ggt ggg aat ttg cca cca gtc agt cct aac gat tct     1276
 Ala Ser Ala Lys Gly Gly Asn Leu Pro Pro Val Ser Pro Asn Asp Ser
 360                 365                 370                 375

 ggt gct aag ata gca tcg aat cct ctg gaa agg cat gtc ata cca gtt     1324
 Gly Ala Lys Ile Ala Ser Asn Pro Leu Glu Arg His Val Ile Pro Val
                 380                 385                 390

 tcc tca agt gac ttc aac aat aaa cat ctc ctt gag cca ctg tgt agt     1372
 Ser Ser Ser Asp Phe Asn Asn Lys His Leu Leu Glu Pro Leu Cys Ser
             395                 400                 405

 gat cct ttg aaa gat acc aac tct gat gag cag cat tcc act tcg gct     1420
 Asp Pro Leu Lys Asp Thr Asn Ser Asp Glu Gln His Ser Thr Ser Ala
         410                 415                 420

 tta act gaa gta gaa atg aac cag cct caa cat gcc aca gag tta atg     1468
 Leu Thr Glu Val Glu Met Asn Gln Pro Gln His Ala Thr Glu Leu Met
     425                 430                 435

 gtg act tct gat cat att gta cct ggt gat atg gcc cgg gaa cca gta     1516
 Val Thr Ser Asp His Ile Val Pro Gly Asp Met Ala Arg Glu Pro Val
 440                 445                 450                 455

 gaa gaa aca aca aaa tcc ccc agt gat gta aac att tct gct caa cca     1564
 Glu Glu Thr Thr Lys Ser Pro Ser Asp Val Asn Ile Ser Ala Gln Pro
                 460                 465                 470

 gct ctt tca aat ttt ata agc cag tta gaa cct gaa gta ttt aat agt     1612
 Ala Leu Ser Asn Phe Ile Ser Gln Leu Glu Pro Glu Val Phe Asn Ser
             475                 480                 485

 ttg gtt aaa atc atg aaa gac gtc cag aaa aat act gtg aaa ttt tat     1660
 Leu Val Lys Ile Met Lys Asp Val Gln Lys Asn Thr Val Lys Phe Tyr
         490                 495                 500

 att cat gaa gaa gaa gag agt gtg ctc tgt aaa gaa ata aag gaa tat     1708
 Ile His Glu Glu Glu Glu Ser Val Leu Cys Lys Glu Ile Lys Glu Tyr
     505                 510                 515

 ctt atc aaa tta ggc aat aca gaa tgt cat cct gaa cag ttt ttg gaa     1756
 Leu Ile Lys Leu Gly Asn Thr Glu Cys His Pro Glu Gln Phe Leu Glu
 520                 525                 530                 535

 aga aga tca aaa tta gat aaa cta ttg att att att caa aat gaa gac     1804
 Arg Arg Ser Lys Leu Asp Lys Leu Leu Ile Ile Ile Gln Asn Glu Asp
                 540                 545                 550

 att gca ggt ttc att cac aag ata cct ggc ttg gtg act tta aag aag     1852
 Ile Ala Gly Phe Ile His Lys Ile Pro Gly Leu Val Thr Leu Lys Lys
             555                 560                 565

 ctc ccc tgt gtt agt ttt gct ggt gtt gat agc ctg gat gat gtt aaa     1900
 Leu Pro Cys Val Ser Phe Ala Gly Val Asp Ser Leu Asp Asp Val Lys
         570                 575                 580

 aat cat aca tac aat gaa tta ttt gta tct gga ggt ttt atc gta tct     1948
 Asn His Thr Tyr Asn Glu Leu Phe Val Ser Gly Gly Phe Ile Val Ser
     585                 590                 595

 gat gaa tca att cta aac cca gag gtt gtc aca gtt gag aac ctt aaa     1996
 Asp Glu Ser Ile Leu Asn Pro Glu Val Val Thr Val Glu Asn Leu Lys
 600                 605                 610                 615

 aat ttt ttg aca ttc ctt gag gaa ctt agt act cca gaa gga aaa tgg     2044
 Asn Phe Leu Thr Phe Leu Glu Glu Leu Ser Thr Pro Glu Gly Lys Trp
                 620                 625                 630

 caa tgg aaa gtc cac tgt aaa ttt cag aag aaa cta aag gaa cta ggc     2092
 Gln Trp Lys Val His Cys Lys Phe Gln Lys Lys Leu Lys Glu Leu Gly
             635                 640                 645

 aga ttg aat gct aaa gct cta agt ctg ttg acg ctt ctg aat gtc tat     2140
 Arg Leu Asn Ala Lys Ala Leu Ser Leu Leu Thr Leu Leu Asn Val Tyr
         650                 655                 660

 cag aag aaa cat ctg gtt gaa att ttg tca tac cac aat tgt gat tca     2188
 Gln Lys Lys His Leu Val Glu Ile Leu Ser Tyr His Asn Cys Asp Ser
     665                 670                 675

 caa act cga aat gct cca gaa ttg gat tgc ctt atc aga ctt cag gct     2236
 Gln Thr Arg Asn Ala Pro Glu Leu Asp Cys Leu Ile Arg Leu Gln Ala
 680                 685                 690                 695

 cag aac ata cag caa cga cac ata gtc ttt tta aca gag aag aac atc     2284
 Gln Asn Ile Gln Gln Arg His Ile Val Phe Leu Thr Glu Lys Asn Ile
                 700                 705                 710

 aag atg ctt tcc agt tat aca gat aat gga ata gtg gtt gca act gct     2332
 Lys Met Leu Ser Ser Tyr Thr Asp Asn Gly Ile Val Val Ala Thr Ala
             715                 720                 725

 gaa gac ttc atg caa aac ttt aaa aat ctt gtg ggc tat cac aat tca     2380
 Glu Asp Phe Met Gln Asn Phe Lys Asn Leu Val Gly Tyr His Asn Ser
         730                 735                 740

 atc aca gaa gaa aac ctt cca cag ctt ggt gct aat gag aat ctt gag     2428
 Ile Thr Glu Glu Asn Leu Pro Gln Leu Gly Ala Asn Glu Asn Leu Glu
     745                 750                 755

 tcg cag tca gct ctt tta gaa aac gat gaa aag gat gaa gag gat atg     2476
 Ser Gln Ser Ala Leu Leu Glu Asn Asp Glu Lys Asp Glu Glu Asp Met
 760                 765                 770                 775

 tct ctg gat tca ggg gat gaa atc tca cat ata gaa gta tgc agc aat     2524
 Ser Leu Asp Ser Gly Asp Glu Ile Ser His Ile Glu Val Cys Ser Asn
                 780                 785                 790

 ttt cat tca gaa ata tgg gag aaa gag acc aaa gga tca cgt gga aca     2572
 Phe His Ser Glu Ile Trp Glu Lys Glu Thr Lys Gly Ser Arg Gly Thr
             795                 800                 805

 gat caa aaa aag aat act caa att gag ttg caa tcg tct cct gat gtg     2620
 Asp Gln Lys Lys Asn Thr Gln Ile Glu Leu Gln Ser Ser Pro Asp Val
         810                 815                 820

 caa aac agt tta tta gaa gat aag act tac ctt gat tct gaa gag aga     2668
 Gln Asn Ser Leu Leu Glu Asp Lys Thr Tyr Leu Asp Ser Glu Glu Arg
     825                 830                 835

 act tct att gat ata gta tgc tct gaa gga gag aac agc aat tca aca     2716
 Thr Ser Ile Asp Ile Val Cys Ser Glu Gly Glu Asn Ser Asn Ser Thr
 840                 845                 850                 855

 gaa caa gat tca tat agt aac ttt cag gtt tat cat agt caa tta aat     2764
 Glu Gln Asp Ser Tyr Ser Asn Phe Gln Val Tyr His Ser Gln Leu Asn
                 860                 865                 870

 atg tcc cat cag ttt agt cat ttt aat gtt ctc act cat cag aca ttt     2812
 Met Ser His Gln Phe Ser His Phe Asn Val Leu Thr His Gln Thr Phe
             875                 880                 885

 ttg ggg aca cca tat gcc ctt tca tca agt cag tct caa gaa aat gag     2860
 Leu Gly Thr Pro Tyr Ala Leu Ser Ser Ser Gln Ser Gln Glu Asn Glu
         890                 895                 900

 aat tac ttc tta tct gct tat act gaa agc ttg gat aga gat aaa tct     2908
 Asn Tyr Phe Leu Ser Ala Tyr Thr Glu Ser Leu Asp Arg Asp Lys Ser
     905                 910                 915

 cca cct ccc tta agt tgg ggg aaa agt gat tct tcc agg cca tat tca     2956
 Pro Pro Pro Leu Ser Trp Gly Lys Ser Asp Ser Ser Arg Pro Tyr Ser
 920                 925                 930                 935

 caa gag aaa taa ctg tagtaacttt ttttttaaga gattgttgtg gactttgttt     3011
 Gln Glu Lys 


 attaacaatt tatatttcat tctctaaaca aaaggttctt gttctttctc aaatgttttt   3071

 tcttttattt aaatcatgat ggcctgtaac agttgaagca tctaaaaatt gaaataaata   3131

 tatattttta acatatattg tacttgaatt atctcatgtt ggcacttcta agttttactt   3191

 tttgtatgtt acctgtactt aggcttcaaa ttgaagcctg ttttatgtgt aaaatcagat   3251

 gcttgcagga ggacggtaaa cagcaaaggc tttacttctt tttctctaat gtcacctgat   3311

 ataaagtact tttgttgaag tgaattattt tgatgtaggc ttttgtatac tgtgtttaca   3371

 caggtataag tcagtaatag cagtgttaat atttacagga ttttggctcg atacctcaag   3431

 atttatctaa cagtgcagtt tcatttagat aataaactat gtacatagga cacatttttt   3491

 atctctaggc ttagtcatgt aaaaactgcc tattgctaaa attctggtaa ctttttgaga   3551

 gtattggata attttcagta cctgcgcaat ccttgattta atgaaattaa attttttatt   3611

 tcaaaagata ggcttctgtt tatcaaaggc gttgaacaat ttgattttta aattagtttt   3671

 agcaaaatgg aagtataatg ggaatatatt tttgaggtgg tcttagtagt aattaccatt   3731

 tgttgaacac attaatgcta tactagacag atacagtgga gatagctttc aaacccgtat   3791

 ctattcctaa ctactgcctc taatactaat tactaacttg ttactaatgc taacttttaa   3851

 aaatgttttt gaaaattgca atttctacaa ataaatgtca tagtgcaaat aaatgtcagg   3911

 atttagagaa ggagcctaaa ctgaatttgt gttatttcag taaaagttat ggagttatgg   3971

 gtctagacgt gttaataagt tagacagaac tttggcactt tagaacaaat gcatgagtgg   4031

 tatttcagtt cctaagttac ataaaaagtg tgaaagaaca ctgtgaggtc ccagcaacgc   4091

 cagactatat taaggtaagt agaaagtgtt tttatagggc ttcaataccc aggtggtgac   4151

 agagcagaag aaccggtttt tttttttttt ttttttacta ctaagctttt acaaaagaag   4211

 tatctgtttt attgtataga acaagtacag cattttacta catagtatac aagtttttaa   4271

 tgagcattta aaaaaataag taaatctagg ctatttgaaa aatacagttg agccagtgag   4331

 cacattttat aatttggaag acacaaatca aatgtgaagg atttgatttt ctacatttaa   4391

 aatgaagaac caaaactctc ttcttgattt tcagctaaag gcaggagact actttccaac   4451

 tccttttgct tctggagaag gccctgaaat cacattgata tatgtttgtt agtaaaatgt   4511

 gcacacctga cttgcaatgt tgtgttaaac tagaattata ttcacttgga aaacatatcg   4571

 cttaggataa aattttgtca ttcaaaaatt ttttcagaaa tgcttgtact agaccacctc   4631

 atttggatat atagctatca catttgtaag attctgtttt tagcataaaa atcaataggg   4691

 atgaaaattt tcttagaact caagactcca taactatggg ggtaaatgaa gtcatccctt   4751

 ctcccccagt ccacccccaa gtgctcttag atactgaagg agtctccctt aacatacagt   4811

 gttttttttt tgttgttgtt tttttgtttt tttttggaga tggagtctcg ctctgtcgcc   4871

 caagctggag tacagtggtg caatctcact gcaagctctg cctcccaggt tcacaccatt   4931

 ctcctgcctc aacctcccga atggctggga ctacaggcac ccaccaccac gcctggctaa   4991

 ctaactaact aactttttgt atttttagta gagacagggt ttcactgtgt tagccaggat   5051

 ggtcttgatc tcctgacctc atgatctgcc tgcctcagcc tcccaaagtg ctgggattac   5111

 aggcttgagc cactgctcct ggccaacatc cagtatttta tcttgactgt cctaacctta   5171

 ccttagatgc taacagaagg gtcctgctca aataacactg ggtgctatat tgatgggtaa   5231

 atgtgtacat cctattcctt cctctttatc tcacaatttt tgtctccact aagcaagaag   5291

 taaactaaca cttcgtcact ctaaagaaat aacttatgta aaactcttag taaccctgtt   5351

 tgtcttcaaa tgagtaaata gaccaaagtg gggggacaat tttctagttc tgtagaggga   5411

 aaaacatctg agtcaacatt ttcaaatgca gagggtattg gtacatgacg acatggaaaa   5471

 gggcactttt aaacacagct tactcttcct caagtacaga gagtatatag tgaatcaaaa   5531

 ctaactacag ccattctttt taaagcccaa gggatggagc aaaggtgtaa ggatgttacc   5591

 tgtttgtttt aatcagagag caaaaagaag tcacaatagt ttgggagaaa aagtagtatg   5651

 gtgagtaagg ttatgcgtat aatttcatac tgaatttatt actatttggg atgtacgtca   5711

 atgttctaac aaacactgcc aacacgtcaa ttttttaaaa agcgtgggcc acattgctaa   5771

 gaatttgtta aagcataact gtattttttg ttttagggcc ttattgatgt tttgccgttc   5831

 caatgtatgc atttttttac tcaataaact tgtcttaatt ttaaaaaaaa aaaa         5885




      <210> 43
      <211> 1174
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (42)..(449)

      <400> 43
 tactactact aaattcgcgg ccggtgcgac ggctgccgaa g    atg gcg gag gtg      53
                                                  Met Ala Glu Val
                                                    1

 cag gtc ctg gtg ctt gat ggt cga ggc cat ctc ctg ggc cgc ctg gcg      101
 Gln Val Leu Val Leu Asp Gly Arg Gly His Leu Leu Gly Arg Leu Ala
   5                  10                  15                  20

 gcc atc gtg gct aaa cag gta ctg ctg ggc cgg aag gtg gtg gtc gta      149
 Ala Ile Val Ala Lys Gln Val Leu Leu Gly Arg Lys Val Val Val Val
                  25                  30                  35

 cgc tgt gaa ggc atc aac att tct ggc aat ttc tac aga aac aag ttg      197
 Arg Cys Glu Gly Ile Asn Ile Ser Gly Asn Phe Tyr Arg Asn Lys Leu
              40                  45                  50

 aag tac ctg gct ttc ctc cgc aag cgg atg aac acc aac cct tcc cga      245
 Lys Tyr Leu Ala Phe Leu Arg Lys Arg Met Asn Thr Asn Pro Ser Arg
          55                  60                  65

 ggc ccc tac cac ttc cgg gcc ccc agc cgc atc ttc tgg cgg acc gtg      293
 Gly Pro Tyr His Phe Arg Ala Pro Ser Arg Ile Phe Trp Arg Thr Val
      70                  75                  80

 cga ggt atg ctg ccc cac aaa acc aag cga ggc cag gcc gct ctg gac      341
 Arg Gly Met Leu Pro His Lys Thr Lys Arg Gly Gln Ala Ala Leu Asp
  85                  90                  95                 100

 cgt ctc aag gtg ttt gac ggc atc cca ccg ccc tac gac aag ccc ctc      389
 Arg Leu Lys Val Phe Asp Gly Ile Pro Pro Pro Tyr Asp Lys Pro Leu
                 105                 110                 115

 tct ttc tct aac aga aaa agc gga tgg tgg ttc ctg ctg ccc tca agg      437
 Ser Phe Ser Asn Arg Lys Ser Gly Trp Trp Phe Leu Leu Pro Ser Arg
             120                 125                 130

 tcg tgc gtc tga agc ctacaagaaa gtttgcctat ctggggcgcc tggctcacga      492
 Ser Cys Val 
         135

 ggttggctgg aagtaccagg cagtgacagc caccctggag gagaagagga aagagaaagc    552

 caagatccac taccggaaga agaaacagct catgaggcta cggaaacagg ccgagaagaa    612

 cgtggagaag aaaattgaca aatacacaga ggtcctcaag acccacggac tcctggtctg    672

 agcccaataa agactgttaa ttcctcatgc gttgcctgcc cttcctccat tgttgccctg    732

 gaatgtacgg gacccagggg cagcagcagt ccaggtgcca caggcagccc tgggacatag    792

 gaagctggga gcaaggaaag ggtcttagtc actgcctccc gaagttgctt gaaagcactc    852

 ggagaattgt gcaggtgtca tttatctatg accaatagga agagcaacca gttactatga    912

 gtgaaaggga gccagaagac tgattggagg gccctatctt gtgagtgggg catctgttgg    972

 actttccacc tggtcatata ctctgcagct gttagaatgt gcaagcactt ggggacagca   1032

 tgagcttgct gttgtacaca gggtatttct agaagcagaa atagactggg aagatgcaca   1092

 accaaggggt tacaggcctc gaccatgctc ctcacctgta ttttgtaatc agaaataaat   1152

 tgcttttaaa gaaaaaaaaa aa                                            1174




      <210> 44
      <211> 5820
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(5820)

      <400> 44
  atg ccc ata gaa ggc att gtg aca tat cac cag tca cat cac tca ggt      48
  Met Pro Ile Glu Gly Ile Val Thr Tyr His Gln Ser His His Ser Gly
    1               5                  10                  15

 ggg att ttg aca tat aac tgc acc cag cac aca ggt gag att gtg act       96
 Gly Ile Leu Thr Tyr Asn Cys Thr Gln His Thr Gly Glu Ile Val Thr
              20                  25                  30

 ctt gta tgc tca tcc tgc caa aag ttg agt gtc acc ctc aca cat gga      144
 Leu Val Cys Ser Ser Cys Gln Lys Leu Ser Val Thr Leu Thr His Gly
          35                  40                  45

 cag aga ctt ctg aag cag tta ctg agc ctc aaa tct gct aag att gcc      192
 Gln Arg Leu Leu Lys Gln Leu Leu Ser Leu Lys Ser Ala Lys Ile Ala
      50                  55                  60

 ctg tgt gag agt ctc atc tct ggt aga gaa aga gct gaa att gtg caa      240
 Leu Cys Glu Ser Leu Ile Ser Gly Arg Glu Arg Ala Glu Ile Val Gln
  65                  70                  75                  80

 aaa cag aca caa act ctt att atg cta gtg gct gac ctg caa caa aag      288
 Lys Gln Thr Gln Thr Leu Ile Met Leu Val Ala Asp Leu Gln Gln Lys
                  85                  90                  95

 gtg tat gca cag cct cgc cag gtg tct act gtt aga gtg agc gca ttg      336
 Val Tyr Ala Gln Pro Arg Gln Val Ser Thr Val Arg Val Ser Ala Leu
             100                 105                 110

 att gga aaa gaa tgg gac cct gcc act tgg aat ggg gac gtg tgg gag      384
 Ile Gly Lys Glu Trp Asp Pro Ala Thr Trp Asn Gly Asp Val Trp Glu
         115                 120                 125

 gac cct gat gaa gct agg ggc tct gag ttt gta aac tct gat gag cct      432
 Asp Pro Asp Glu Ala Arg Gly Ser Glu Phe Val Asn Ser Asp Glu Pro
     130                 135                 140

 ttt ttg gaa ggt cca gaa gat ata ccc ttg acc att gcc ttg caa aat      480
 Phe Leu Glu Gly Pro Glu Asp Ile Pro Leu Thr Ile Ala Leu Gln Asn
 145                 150                 155                 160

 aga ttt gtg aag gca gca cct gaa tct ttg aag aac ctt ata att gct      528
 Arg Phe Val Lys Ala Ala Pro Glu Ser Leu Lys Asn Leu Ile Ile Ala
                 165                 170                 175

 ctt ctc tgc atg tcg gat cta aca gtg gga acc ccg gtc act caa cta      576
 Leu Leu Cys Met Ser Asp Leu Thr Val Gly Thr Pro Val Thr Gln Leu
             180                 185                 190

 caa aat tta aat aca gtg gga ata att gga tcc cat gga tat ctc tgg      624
 Gln Asn Leu Asn Thr Val Gly Ile Ile Gly Ser His Gly Tyr Leu Trp
         195                 200                 205

 cct ttt atg agg gtt att gtg cac tgg gga aag gga aat gat tgg aca      672
 Pro Phe Met Arg Val Ile Val His Trp Gly Lys Gly Asn Asp Trp Thr
     210                 215                 220

 ttt tgg gga ctc cta aac act ggc tct gag ctg aca ttg att cca ggg      720
 Phe Trp Gly Leu Leu Asn Thr Gly Ser Glu Leu Thr Leu Ile Pro Gly
 225                 230                 235                 240

 gac cca aaa cat cac tgt ggt cct cca gtt aaa gta gaa gct tat gga      768
 Asp Pro Lys His His Cys Gly Pro Pro Val Lys Val Glu Ala Tyr Gly
                 245                 250                 255

 ggt cag gag aca gat gga ttt tgg aga atg aca gtg gat tat cat gag      816
 Gly Gln Glu Thr Asp Gly Phe Trp Arg Met Thr Val Asp Tyr His Glu
             260                 265                 270

 gtt aat caa gtg gta act cca att gca gct gct gta cca gat gta gtt      864
 Val Asn Gln Val Val Thr Pro Ile Ala Ala Ala Val Pro Asp Val Val
         275                 280                 285

 tca ttg ctt gag caa att acc aca tct cct gat aac tac tct cct ttt      912
 Ser Leu Leu Glu Gln Ile Thr Thr Ser Pro Asp Asn Tyr Ser Pro Phe
     290                 295                 300

 gag aga caa ctc ttg gcc tat tac tgg gct ttg gta aaa act gaa ctt      960
 Glu Arg Gln Leu Leu Ala Tyr Tyr Trp Ala Leu Val Lys Thr Glu Leu
 305                 310                 315                 320

 ttg act atg ggt tgt caa gtc acc atg cga cct gaa ctg cct atc atg     1008
 Leu Thr Met Gly Cys Gln Val Thr Met Arg Pro Glu Leu Pro Ile Met
                 325                 330                 335

 aac tgg gtg ctt tct gac cca tct aac cat aaa ggc ctg aaa ggg cgg     1056
 Asn Trp Val Leu Ser Asp Pro Ser Asn His Lys Gly Leu Lys Gly Arg
             340                 345                 350

 ggc ctt aaa cat tat cca atc agg gat gct ggg ctg gga acg tcc aat     1104
 Gly Leu Lys His Tyr Pro Ile Arg Asp Ala Gly Leu Gly Thr Ser Asn
         355                 360                 365

 cag gca ggc agc tgg agg gga cag gtc ggc ttc cgg gat gtg gtc ggt     1152
 Gln Ala Gly Ser Trp Arg Gly Gln Val Gly Phe Arg Asp Val Val Gly
     370                 375                 380

 cct ttg tct ctc gct gca gcc gga ggt caa ggt ctc gtc ctt act gct     1200
 Pro Leu Ser Leu Ala Ala Ala Gly Gly Gln Gly Leu Val Leu Thr Ala
 385                 390                 395                 400

 gtg tgt cct ctg ctc cta gag tcc cag cct ctg tgg ccc tat gac ctg     1248
 Val Cys Pro Leu Leu Leu Glu Ser Gln Pro Leu Trp Pro Tyr Asp Leu
                 405                 410                 415

 cag gga tca ttg aca ttt agg gat gtg gcc ata gaa ttc tct ctg gag     1296
 Gln Gly Ser Leu Thr Phe Arg Asp Val Ala Ile Glu Phe Ser Leu Glu
             420                 425                 430

 gag tgg caa tgc ctg gac act gca cag cag aat tta tat aga aat gtg     1344
 Glu Trp Gln Cys Leu Asp Thr Ala Gln Gln Asn Leu Tyr Arg Asn Val
         435                 440                 445

 atg tta gag aac tac aga aac ctg gtc ttc ctg ggt att gct gcc ttt     1392
 Met Leu Glu Asn Tyr Arg Asn Leu Val Phe Leu Gly Ile Ala Ala Phe
     450                 455                 460

 aag cca gac ctg atc att ttt ctg gag gaa gga aaa gag tcc tgg aat     1440
 Lys Pro Asp Leu Ile Ile Phe Leu Glu Glu Gly Lys Glu Ser Trp Asn
 465                 470                 475                 480

 atg aag aga cat gag atg gtg gaa gaa tcc cca gtt ata tgt tct cat     1488
 Met Lys Arg His Glu Met Val Glu Glu Ser Pro Val Ile Cys Ser His
                 485                 490                 495

 ttt gct caa gat ctt tgg cca gag cag ggc ata gaa gat tct ttc caa     1536
 Phe Ala Gln Asp Leu Trp Pro Glu Gln Gly Ile Glu Asp Ser Phe Gln
             500                 505                 510

 aaa gtg ata ttg aga agg tat gaa aaa tgt gga cat gag aat tta cac     1584
 Lys Val Ile Leu Arg Arg Tyr Glu Lys Cys Gly His Glu Asn Leu His
         515                 520                 525

 tta aaa att ggt tat acc aat gtg gat gag tgt aag gtg cac aaa gaa     1632
 Leu Lys Ile Gly Tyr Thr Asn Val Asp Glu Cys Lys Val His Lys Glu
     530                 535                 540

 ggt tat aat aaa ctt aac cag agt ttg aca act aca cag agc aaa gta     1680
 Gly Tyr Asn Lys Leu Asn Gln Ser Leu Thr Thr Thr Gln Ser Lys Val
 545                 550                 555                 560

 ttt caa cgt ggc aaa tat gca aat gtc ttt cat aaa tgt tca aat tca     1728
 Phe Gln Arg Gly Lys Tyr Ala Asn Val Phe His Lys Cys Ser Asn Ser
                 565                 570                 575

 aac aga cat aag ata agg cat act gga aag aaa cat ttg caa tgt aaa     1776
 Asn Arg His Lys Ile Arg His Thr Gly Lys Lys His Leu Gln Cys Lys
             580                 585                 590

 gaa tac gtc aga tca ttt tgc atg ctt tca cac cta tct caa cat aaa     1824
 Glu Tyr Val Arg Ser Phe Cys Met Leu Ser His Leu Ser Gln His Lys
         595                 600                 605

 aga att tat act aga gag aat tcc tac aaa tgt gaa gaa ggt ggc aaa     1872
 Arg Ile Tyr Thr Arg Glu Asn Ser Tyr Lys Cys Glu Glu Gly Gly Lys
     610                 615                 620

 gct ttt aac tgg tcc tca acc ctt act tat tat aag agt gct cat act     1920
 Ala Phe Asn Trp Ser Ser Thr Leu Thr Tyr Tyr Lys Ser Ala His Thr
 625                 630                 635                 640

 gga gag aaa ccc tac aga tgt aaa gaa tgt ggc aaa gcc ttt agt aag     1968
 Gly Glu Lys Pro Tyr Arg Cys Lys Glu Cys Gly Lys Ala Phe Ser Lys
                 645                 650                 655

 ttc tca atc ctt act aaa cat aag gta att cat act gga gag aaa tcc     2016
 Phe Ser Ile Leu Thr Lys His Lys Val Ile His Thr Gly Glu Lys Ser
             660                 665                 670

 tac aaa tgt gaa gaa tgt ggc aag gct ttt aac caa tct gca atc ctt     2064
 Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Asn Gln Ser Ala Ile Leu
         675                 680                 685

 act aaa cat aag ata att cat act gga gag aaa ccc aac aaa tgt gaa     2112
 Thr Lys His Lys Ile Ile His Thr Gly Glu Lys Pro Asn Lys Cys Glu
     690                 695                 700

 gaa tgt ggc aaa gcc ttt agt aag gtc tcg act ctt act aca cat aag     2160
 Glu Cys Gly Lys Ala Phe Ser Lys Val Ser Thr Leu Thr Thr His Lys
 705                 710                 715                 720

 gca att cat gct gga gag aag ccc tac aaa tgt aaa gaa tgt ggc aaa     2208
 Ala Ile His Ala Gly Glu Lys Pro Tyr Lys Cys Lys Glu Cys Gly Lys
                 725                 730                 735

 gcc ttc agt aag gtc tca acc ctt att aca cat aag gca att cat gct     2256
 Ala Phe Ser Lys Val Ser Thr Leu Ile Thr His Lys Ala Ile His Ala
             740                 745                 750

 gga gag aag ccc tac aaa tgt aaa gaa tgt ggc aaa gcc ttt agt aag     2304
 Gly Glu Lys Pro Tyr Lys Cys Lys Glu Cys Gly Lys Ala Phe Ser Lys
         755                 760                 765

 ttc tca atc ctt act aaa cat aag gta att cat act gga gag aaa ccc     2352
 Phe Ser Ile Leu Thr Lys His Lys Val Ile His Thr Gly Glu Lys Pro
     770                 775                 780

 tac aaa tgt gaa gaa tgc ggc aaa gcc tat aag tgg ccc tca acc ctt     2400
 Tyr Lys Cys Glu Glu Cys Gly Lys Ala Tyr Lys Trp Pro Ser Thr Leu
 785                 790                 795                 800

 agt tat cat aag aaa att cat act gga gag aaa ccc tac aaa tgt gaa     2448
 Ser Tyr His Lys Lys Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu
                 805                 810                 815

 gaa tgt ggc aaa ggt ttt agt atg ttc tca atc ctt act aaa cat gag     2496
 Glu Cys Gly Lys Gly Phe Ser Met Phe Ser Ile Leu Thr Lys His Glu
             820                 825                 830

 gtc att cat act gga gag aaa ccc tac aaa tgt gaa gaa tgt ggc aaa     2544
 Val Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys
         835                 840                 845

 gct ttc aac tgg tcc tca aac ctt atg gaa cat aag aaa att cac act     2592
 Ala Phe Asn Trp Ser Ser Asn Leu Met Glu His Lys Lys Ile His Thr
     850                 855                 860

 gga gag aca ccc tac aaa tgt gaa gaa tgt ggc aaa ggc ttt agt atg     2640
 Gly Glu Thr Pro Tyr Lys Cys Glu Glu Cys Gly Lys Gly Phe Ser Met
 865                 870                 875                 880

 ttc tca atc ctt act aaa cat aag gta att cat aat gga gag aaa ccc     2688
 Phe Ser Ile Leu Thr Lys His Lys Val Ile His Asn Gly Glu Lys Pro
                 885                 890                 895

 tac aaa tgt gaa gaa tgt gat aag gca act cat gct gga gag aaa ccc     2736
 Tyr Lys Cys Glu Glu Cys Asp Lys Ala Thr His Ala Gly Glu Lys Pro
             900                 905                 910

 tac aaa tgt gaa gaa tgt ggc aaa gct ttc aac tgg tcc tca aac ctt     2784
 Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Asn Trp Ser Ser Asn Leu
         915                 920                 925

 atg gaa cat aag aga att cat act gga gag aaa ccc tac aaa tgt gaa     2832
 Met Glu His Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu
     930                 935                 940

 gaa tgt ggc aaa agc ttc agt aca ttc tca atc ctt act aaa cat aag     2880
 Glu Cys Gly Lys Ser Phe Ser Thr Phe Ser Ile Leu Thr Lys His Lys
 945                 950                 955                 960

 gta att cat act gga gag aaa ccc tac aaa tgt gaa gaa tgt ggc aaa     2928
 Val Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys
                 965                 970                 975

 gcc tat aag tgg tcc tca acc ctt agt tat cat aag aaa att cat act     2976
 Ala Tyr Lys Trp Ser Ser Thr Leu Ser Tyr His Lys Lys Ile His Thr
             980                 985                 990

 gta gag aaa ccc tac aaa tgt gaa gaa tgt ggc aaa gct ttt aac caa     3024
 Val Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Asn Gln
         995                1000                1005

 tct gca att ctt att aaa cat aag aga att cat act ggt gag aaa ccc     3072
 Ser Ala Ile Leu Ile Lys His Lys Arg Ile His Thr Gly Glu Lys Pro
    1010                1015                1020

 tac aaa tgt gaa gaa tgt ggc aaa acc ttt agt aag gtc tca acc ctt     3120
 Tyr Lys Cys Glu Glu Cys Gly Lys Thr Phe Ser Lys Val Ser Thr Leu
1025                1030                1035                1040

 act aca cat aag gca att cat gct gga gag aag ccc tac aaa tgt aaa     3168
 Thr Thr His Lys Ala Ile His Ala Gly Glu Lys Pro Tyr Lys Cys Lys
                1045                1050                1055

 gaa tgt ggc aaa acc ttt att aag gtc tca acc ctt act aca cat aag     3216
 Glu Cys Gly Lys Thr Phe Ile Lys Val Ser Thr Leu Thr Thr His Lys
            1060                1065                1070

 gca att cat gct gga gag aag ccc tac aaa tgt aaa gaa tgt ggc aaa     3264
 Ala Ile His Ala Gly Glu Lys Pro Tyr Lys Cys Lys Glu Cys Gly Lys
        1075                1080                1085

 gcc ttt agt aag ttc tca atc ctt act aaa cat aag gta att cat act     3312
 Ala Phe Ser Lys Phe Ser Ile Leu Thr Lys His Lys Val Ile His Thr
    1090                1095                1100

 gga gag aaa ccc tac aaa tgt gaa gaa tgt ggc aaa gct ttc aac tgg     3360
 Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Asn Trp
1105                1110                1115                1120

 tcc tca aac ctt atg gaa cat aag aga att cat act gga gag aaa ccc     3408
 Ser Ser Asn Leu Met Glu His Lys Arg Ile His Thr Gly Glu Lys Pro
                1125                1130                1135

 tac aaa tgt gaa gaa tgt ggc aaa agc ttt agt aca ttc tca gtc ctt     3456
 Tyr Lys Cys Glu Glu Cys Gly Lys Ser Phe Ser Thr Phe Ser Val Leu
            1140                1145                1150

 act aaa cat aag gta att cat act gga gag aaa ccc tac aaa tgt gaa     3504
 Thr Lys His Lys Val Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu
        1155                1160                1165

 gaa tgt ggc aaa gcc tat aag tgg tcc tca acc ctt agt tat cat aag     3552
 Glu Cys Gly Lys Ala Tyr Lys Trp Ser Ser Thr Leu Ser Tyr His Lys
    1170                1175                1180

 aaa att cat act gta gag aaa ccc tac aaa tgt gaa gaa tgt ggc aaa     3600
 Lys Ile His Thr Val Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys
1185                1190                1195                1200

 gct ttt aac cga tct gca atc ctt att aaa cat aag aga att cat act     3648
 Ala Phe Asn Arg Ser Ala Ile Leu Ile Lys His Lys Arg Ile His Thr
                1205                1210                1215

 gat gag aaa ccc tac aaa tgt gaa gaa tgt ggc aaa acc ttt agt aag     3696
 Asp Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys Thr Phe Ser Lys
            1220                1225                1230

 gtc tca acc ctt act aca cat aag gca att cat gct gga gaa aag ccc     3744
 Val Ser Thr Leu Thr Thr His Lys Ala Ile His Ala Gly Glu Lys Pro
        1235                1240                1245

 tac aaa tgt aaa gaa tgt ggc aaa gcc ttt agt aag ttc tca atc ctt     3792
 Tyr Lys Cys Lys Glu Cys Gly Lys Ala Phe Ser Lys Phe Ser Ile Leu
    1250                1255                1260

 act aaa cat aag gta att cat act gga gag aaa ccc tac aaa tgt gaa     3840
 Thr Lys His Lys Val Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu
1265                1270                1275                1280

 gaa tgt ggc aaa gcc tat aaa tgg ccc tca acc ctt agt tat cat aag     3888
 Glu Cys Gly Lys Ala Tyr Lys Trp Pro Ser Thr Leu Ser Tyr His Lys
                1285                1290                1295

 aaa att cat act gga gag aaa ccc tac aaa tgt gaa gaa tgt ggc aaa     3936
 Lys Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys
            1300                1305                1310

 ggt ttt agt atg ttc tcc atc ctt act aaa cat gag gta att cat act     3984
 Gly Phe Ser Met Phe Ser Ile Leu Thr Lys His Glu Val Ile His Thr
        1315                1320                1325

 gga gag aaa ccc tac aaa tgt gaa gaa tgt ggc aaa gcc ttc agc tgg     4032
 Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Ser Trp
    1330                1335                1340

 ttg tca gtc ttt agt aaa cat aag aaa act cat gct gga gag aaa ttc     4080
 Leu Ser Val Phe Ser Lys His Lys Lys Thr His Ala Gly Glu Lys Phe
1345                1350                1355                1360

 tac aaa tgt gaa gca tgt ggc aaa gcc tat aag tca tcc tca acc ctt     4128
 Tyr Lys Cys Glu Ala Cys Gly Lys Ala Tyr Lys Ser Ser Ser Thr Leu
                1365                1370                1375

 agt tat cat aag aaa att cat act gaa gag aaa cct tac aaa tat gaa     4176
 Ser Tyr His Lys Lys Ile His Thr Glu Glu Lys Pro Tyr Lys Tyr Glu
            1380                1385                1390

 gaa tgt ggc aaa ggc ttt agt aca ttc tca atc ctt act aaa cat aag     4224
 Glu Cys Gly Lys Gly Phe Ser Thr Phe Ser Ile Leu Thr Lys His Lys
        1395                1400                1405

 gta att cat act gga gag aaa ccc tac aaa tgt gaa gaa tgt ggc aaa     4272
 Val Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys
    1410                1415                1420

 gct ttc aac tgg tca tca aac ctt atg gaa cat aag aaa att cac act     4320
 Ala Phe Asn Trp Ser Ser Asn Leu Met Glu His Lys Lys Ile His Thr
1425                1430                1435                1440

 gga gag aca ccc tac aaa tgt gaa gaa tgt gac aaa gcc ttc agc tgg     4368
 Gly Glu Thr Pro Tyr Lys Cys Glu Glu Cys Asp Lys Ala Phe Ser Trp
                1445                1450                1455

 ccc tca agc ctt act gaa cat aag gca act cat gct gga gaa aaa ccc     4416
 Pro Ser Ser Leu Thr Glu His Lys Ala Thr His Ala Gly Glu Lys Pro
            1460                1465                1470

 tac aaa tgt gaa gaa tgt ggc aaa gcc ttc agc tgg ccc tca aga ctt     4464
 Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Ser Trp Pro Ser Arg Leu
        1475                1480                1485

 act gaa cat aag gca act cat gct gga gag gaa ccc tac aaa tgt gaa     4512
 Thr Glu His Lys Ala Thr His Ala Gly Glu Glu Pro Tyr Lys Cys Glu
    1490                1495                1500

 gaa tgt ggc aaa gct ttc aac tgg tcc tca aac ctt atg gaa cat aag     4560
 Glu Cys Gly Lys Ala Phe Asn Trp Ser Ser Asn Leu Met Glu His Lys
1505                1510                1515                1520

 aga att cat act gga gag aaa ccc tac aaa tgt gaa gaa tgt ggc aaa     4608
 Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys
                1525                1530                1535

 agc ttt agt acg ttc tca atc ctt act aaa cat aag gta att cat act     4656
 Ser Phe Ser Thr Phe Ser Ile Leu Thr Lys His Lys Val Ile His Thr
            1540                1545                1550

 gga gag aaa ccc tac aaa tgt gaa gaa tgt ggc aaa gcc tat aag tgg     4704
 Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys Ala Tyr Lys Trp
        1555                1560                1565

 tcc tca acc ctt agt tat cat aag aaa att cat act gta gag aaa ccc     4752
 Ser Ser Thr Leu Ser Tyr His Lys Lys Ile His Thr Val Glu Lys Pro
    1570                1575                1580

 tac aaa tgt gaa gaa tgt ggc aaa ggc ttt gtt atg ttc tca atc ctt     4800
 Tyr Lys Cys Glu Glu Cys Gly Lys Gly Phe Val Met Phe Ser Ile Leu
1585                1590                1595                1600

 gca aaa cat aag gta att cat act gga gag aaa ctc tac aaa tgt gaa     4848
 Ala Lys His Lys Val Ile His Thr Gly Glu Lys Leu Tyr Lys Cys Glu
                1605                1610                1615

 gaa tgt ggc aaa gcc tat aag tgg ccc tca acc ctt aga tat cac aag     4896
 Glu Cys Gly Lys Ala Tyr Lys Trp Pro Ser Thr Leu Arg Tyr His Lys
            1620                1625                1630

 aaa att cat act gga gag aaa ccc tac aaa tgt gaa gaa tgt ggc aaa     4944
 Lys Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys
        1635                1640                1645

 gcc ttt agt acg ttc tca atc ctc act aaa cat aag gta att cat act     4992
 Ala Phe Ser Thr Phe Ser Ile Leu Thr Lys His Lys Val Ile His Thr
    1650                1655                1660

 gga gag aaa ccc tac aaa tgt gaa gaa tgt ggc aaa gcc ttc agc tgt     5040
 Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Ser Cys
1665                1670                1675                1680

 tat cat aag aaa att cat act gga gag aaa ccc tac aaa tgt gaa gaa     5088
 Tyr His Lys Lys Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Glu
                1685                1690                1695

 tgt ggt gag gct ttc aac tgg tcc tca aac ctt atg gaa cat aag aga     5136
 Cys Gly Glu Ala Phe Asn Trp Ser Ser Asn Leu Met Glu His Lys Arg
            1700                1705                1710

 att cat act gga gag aca ccc tac aaa tgt gaa gaa tgt ggt aaa ggc     5184
 Ile His Thr Gly Glu Thr Pro Tyr Lys Cys Glu Glu Cys Gly Lys Gly
        1715                1720                1725

 ttt agt atg ttc tca atc ctt act aaa cat aag gta att cat act gga     5232
 Phe Ser Met Phe Ser Ile Leu Thr Lys His Lys Val Ile His Thr Gly
    1730                1735                1740

 gag aaa cca tac aaa tgc aaa gaa tgt ggc aaa gcc tat aag tgg tcc     5280
 Glu Lys Pro Tyr Lys Cys Lys Glu Cys Gly Lys Ala Tyr Lys Trp Ser
1745                1750                1755                1760

 tca acc ctc agt tat cat aga aaa ttc ata ctg gag aga aac cct aca     5328
 Ser Thr Leu Ser Tyr His Arg Lys Phe Ile Leu Glu Arg Asn Pro Thr
                1765                1770                1775

 aat gtg aag aaa gtg gca aag cct tca gct ggt tct cag tct tta aat     5376
 Asn Val Lys Lys Val Ala Lys Pro Ser Ala Gly Ser Gln Ser Leu Asn
            1780                1785                1790

 tca tac tgg agg aaa aac cct aca aat atg aaa aat gtg gca aaa cta     5424
 Ser Tyr Trp Arg Lys Asn Pro Thr Asn Met Lys Asn Val Ala Lys Leu
        1795                1800                1805

 tta att aat tct caa cgc tta ctg aac ata agg gaa ttt gta cag gag     5472
 Leu Ile Asn Ser Gln Arg Leu Leu Asn Ile Arg Glu Phe Val Gln Glu
    1810                1815                1820

 gga aac cct aca aat ctg aag aat gtg gca agc ctt tta gct att cct     5520
 Gly Asn Pro Thr Asn Leu Lys Asn Val Ala Ser Leu Leu Ala Ile Pro
1825                1830                1835                1840

 caa tcc tta cta aac att cat gta att cat act gga ggg aat tcc tac     5568
 Gln Ser Leu Leu Asn Ile His Val Ile His Thr Gly Gly Asn Ser Tyr
                1845                1850                1855

 aat tgt gtg gaa tgt tgc aat gcc ctt aac cag tcc tta agg ctt act     5616
 Asn Cys Val Glu Cys Cys Asn Ala Leu Asn Gln Ser Leu Arg Leu Thr
            1860                1865                1870

 aca tat aag aca act cat act gga gag aaa cca tgc atg tgt gaa gaa     5664
 Thr Tyr Lys Thr Thr His Thr Gly Glu Lys Pro Cys Met Cys Glu Glu
        1875                1880                1885

 tgt ggg aaa gcc tct aat aga tcc tca att ctt aag aga cat aag cta     5712
 Cys Gly Lys Ala Ser Asn Arg Ser Ser Ile Leu Lys Arg His Lys Leu
    1890                1895                1900

 att cat aca caa gag aga ctc tac aaa cct gaa aga tgt gac aat gct     5760
 Ile His Thr Gln Glu Arg Leu Tyr Lys Pro Glu Arg Cys Asp Asn Ala
1905                1910                1915                1920

 ttt ggc aac acc tca gac ttt tct gaa tat aaa aga aat cgt aca gat     5808
 Phe Gly Asn Thr Ser Asp Phe Ser Glu Tyr Lys Arg Asn Arg Thr Asp
                1925                1930                1935

 gag aaa tcc tag                                                     5820
 Glu Lys Ser 






      <210> 45
      <211> 604
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (225)..(596)

      <400> 45
 cggtacgagc gaaagtgctt tggcggtttg tccatccgca gcttcggctt ttccagtctg     60

 gtggcccttc cggccacccc tttaacccca gctttccctc ccccttcttt cgatcagaga    120

 tcggcggaga ccctcgaagt gcgcaaactt gacactcacc ctgaccggac tggggtttta    180

 aggggtgtgg caggaggttt tggactcgat gagtttccac cgaa atg tcg gag aag     236
                                                  Met Ser Glu Lys
                                                    1

 tca ggc cag agc aca aaa gca aag gat ggg aaa aag tat gca aca ctc      284
 Ser Gly Gln Ser Thr Lys Ala Lys Asp Gly Lys Lys Tyr Ala Thr Leu
   5                  10                  15                  20

 agt tta ttt aat act tac aag ggg aaa tca tta gaa aca cag aaa acc      332
 Ser Leu Phe Asn Thr Tyr Lys Gly Lys Ser Leu Glu Thr Gln Lys Thr
                  25                  30                  35

 aca gct cga cat gga tta cag agt ctt gga aaa gtc ggt att tca cgg      380
 Thr Ala Arg His Gly Leu Gln Ser Leu Gly Lys Val Gly Ile Ser Arg
              40                  45                  50

 cgt atg cct cca cct gct aac ctc cca agt ctt aaa gca gaa aac aaa      428
 Arg Met Pro Pro Pro Ala Asn Leu Pro Ser Leu Lys Ala Glu Asn Lys
          55                  60                  65

 ggc aat gat cct aat gta aac att gta cct aaa gat ggc aca ggg tgg      476
 Gly Asn Asp Pro Asn Val Asn Ile Val Pro Lys Asp Gly Thr Gly Trp
      70                  75                  80

 gca tca aaa caa gag caa cat gaa gaa gaa aaa aac acc aga agt gcc      524
 Ala Ser Lys Gln Glu Gln His Glu Glu Glu Lys Asn Thr Arg Ser Ala
  85                  90                  95                 100

 acc agc aca gcc aaa acc tgt ggt tgc agc tcc ccc aga agt agc acc      572
 Thr Ser Thr Ala Lys Thr Cys Gly Cys Ser Ser Pro Arg Ser Ser Thr
                 105                 110                 115

 tgc tcc caa atc atg ggc cag taa caagcaag                             604
 Cys Ser Gln Ile Met Gly Gln 
             120





      <210> 46
      <211> 1418
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (108)..(317)

      <400> 46
 ccactttgta caagaaagct gggtacgcgt aagcttgggc ccctcgaggg atactctaga     60

 gcggccgctc gcgatctaga actagcagag cctggagcat ctccact  atg gcc tgg     116
                                                      Met Ala Trp
                                                        1

 gct cca cta ctt ctc acc ctc ctc gct cac tgc aca ggt tct tgg gcc      164
 Ala Pro Leu Leu Leu Thr Leu Leu Ala His Cys Thr Gly Ser Trp Ala
       5                  10                  15

 agt ttt atg ctg act cag ccc cac tct atg tcg gag tct ccg ggg aag      212
 Ser Phe Met Leu Thr Gln Pro His Ser Met Ser Glu Ser Pro Gly Lys
  20                  25                  30                  35

 acg gca acc att tcc tgc acc cgc agc agt ggc aac att gcc agc tac      260
 Thr Ala Thr Ile Ser Cys Thr Arg Ser Ser Gly Asn Ile Ala Ser Tyr
                  40                  45                  50

 tat gta cag tgg tac cag cag cgc ccc ggg cag ttc ccc cat tac tgt      308
 Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Gln Phe Pro His Tyr Cys
              55                  60                  65

 gat cta tga cgatgac ctaagaccct ctggggtccc tgatcggttc tctggctcca      364
 Asp Leu 


 tcgacaggtc ctccaactct gcctccctca ccatctctag actgatgact gaggacgagg    424

 ctgactacta ctgtcagtct tttgatgagt ataatcacag agtgttcggc ggagggacca    484

 ggctgaccgt cctaggtcag cccaaggctg ccccctcggt cactctgttc ccgccctcct    544

 ctgaggagct tcaagccaac aaggccacac tggtgtgtct cataagtgac ttctacccgg    604

 gagccgtgac agtggcctgg aaggcagata gcagccccgt caaggcggga gtggagacca    664

 ccacaccctc caaacaaagc aacaacaagt acgcggccag cagctacctg agcctgacgc    724

 ctgagcagtg gaagtcccac agaagctaca gctgccagaa acctaaccac gcatcacacg    784

 gcacttctcg catgccttct gtgtctgctc cagtctctgg gctaaagagt tgctggtccg    844

 ggacagggga taggtccgct cttggtcaga tgccaggtcc ctgccatggc atccctgacc    904

 ctatgcaaca agccagtgac tctggtcagc ccaaggctgc cccctcggtc actctgttcc    964

 caccctcctc tgaggagctt caagccaaca aggccacact ggtgtgtctc ataagtgact   1024

 tctacccggg agccgtgaca gtggcctgga aggcagatag cagccccgtc aaggcgggag   1084

 tggagaccac cacaccctcc aaacaaagca acaacaagta cgcggccagc agctacctga   1144

 gcctgacgcc tgagcagtgg aagtcccaca aaagctacag ctgccaggtc acgcatgaag   1204

 ggagcaccgt ggagaagaca gtggccccta cagaatgttc ataggttctc atccctcacc   1264

 ccccaccacg ggagactaga gctgcaggat cccaggggag gggtctctcc tcccacccca   1324

 aggcatcaag cccttctccc tgcactcaat aaaccctcaa taaatattct cattgtcaat   1384

 cagagtcgac gcggccgcga atttagtagt agta                               1418




      <210> 47
      <211> 769
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (49)..(714)

      <400> 47
 aattggaccc gctctgcacc gcgctgcagg aattcggcac gagccaac atg gtg ttc      57
                                                      Met Val Phe
                                                        1

 agg cgc ttc gtg gag gtt ggc cgg gtg gcc tat gtc tcc ttt gga cct      105
 Arg Arg Phe Val Glu Val Gly Arg Val Ala Tyr Val Ser Phe Gly Pro
       5                  10                  15

 cat gcc gga aaa ttg gtc gcg att gta gat gtt att gat cag aac agg      153
 His Ala Gly Lys Leu Val Ala Ile Val Asp Val Ile Asp Gln Asn Arg
  20                  25                  30                  35

 gct ttg gtc gat gga cct tgc act caa gtg agg aga cag gcc atg cct      201
 Ala Leu Val Asp Gly Pro Cys Thr Gln Val Arg Arg Gln Ala Met Pro
                  40                  45                  50

 ttc aag tgc atg cag ctc act gat ttc atc ctc aag ttt ccg cac agt      249
 Phe Lys Cys Met Gln Leu Thr Asp Phe Ile Leu Lys Phe Pro His Ser
              55                  60                  65

 gcc cac cag aag tat gtc cga caa gcc tgg cag aag gca gac atc aat      297
 Ala His Gln Lys Tyr Val Arg Gln Ala Trp Gln Lys Ala Asp Ile Asn
          70                  75                  80

 aca aaa tgg gca gcc aca cga tgg gcc aag aag att gaa gcc aga gaa      345
 Thr Lys Trp Ala Ala Thr Arg Trp Ala Lys Lys Ile Glu Ala Arg Glu
      85                  90                  95

 agg aaa gcc aag atg aca gat ttt gat cgt ttt aaa gtt atg aag gca      393
 Arg Lys Ala Lys Met Thr Asp Phe Asp Arg Phe Lys Val Met Lys Ala
 100                 105                 110                 115

 aag aaa atg agg aac aga ata atc aag aat gaa gtt aag aag ctt caa      441
 Lys Lys Met Arg Asn Arg Ile Ile Lys Asn Glu Val Lys Lys Leu Gln
                 120                 125                 130

 aag gca gct ctc ctg aaa gct tct ccc aaa aaa gca cct ggt act aag      489
 Lys Ala Ala Leu Leu Lys Ala Ser Pro Lys Lys Ala Pro Gly Thr Lys
             135                 140                 145

 ggt act gct gct gct gct gct gct gct gct gct gct gct gct gct gct      537
 Gly Thr Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala
         150                 155                 160

 gct gct aaa gtt cca gca aaa aag atc acc gcc gcg agt aaa aag gct      585
 Ala Ala Lys Val Pro Ala Lys Lys Ile Thr Ala Ala Ser Lys Lys Ala
     165                 170                 175

 cca gcc cag aag gtt cct gcc cag aaa gcc aca ggc cag aaa gca gcg      633
 Pro Ala Gln Lys Val Pro Ala Gln Lys Ala Thr Gly Gln Lys Ala Ala
 180                 185                 190                 195

 cct gct cca aaa gct cag aag ggt caa aaa gct cca gcc cag aaa gca      681
 Pro Ala Pro Lys Ala Gln Lys Gly Gln Lys Ala Pro Ala Gln Lys Ala
                 200                 205                 210

 cct gct cca aag gca tct ggc aag aaa gca taa gtggcaat cataaaaagt      732
 Pro Ala Pro Lys Ala Ser Gly Lys Lys Ala 
             215                 220

 aataaaggtt ctttttgacc tgttgaaaaa aaaaaaa                             769




      <210> 48
      <211> 1528
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (62)..(1528)

      <400> 48
 agaaaaaatt gacccgcgct gcaggaaatc gacacgcgct gcaggaattc ggcacgagcg     60

 g    atg ccg aag gtg aag gcg ctg cag tgc gcc ctg gcg ctg gag atc     106
      Met Pro Lys Val Lys Ala Leu Gln Cys Ala Leu Ala Leu Glu Ile
        1               5                  10                  15

 agc tca gta act tgc cca gga gtc gtg ctt aaa gac aaa gag gac atc      154
 Ser Ser Val Thr Cys Pro Gly Val Val Leu Lys Asp Lys Glu Asp Ile
                  20                  25                  30

 tat ctt agc atc tgt gtg ttt ggc caa tac aaa aag aca caa tgt gtc      202
 Tyr Leu Ser Ile Cys Val Phe Gly Gln Tyr Lys Lys Thr Gln Cys Val
              35                  40                  45

 cca gcc act ttt ccc ctg gtc ttc aat gcc aga atg gtg ttt gaa aag      250
 Pro Ala Thr Phe Pro Leu Val Phe Asn Ala Arg Met Val Phe Glu Lys
          50                  55                  60

 gtg ttc ccg gac gca gta gat cct gga gat gtg gtt aca cag ctt gaa      298
 Val Phe Pro Asp Ala Val Asp Pro Gly Asp Val Val Thr Gln Leu Glu
      65                  70                  75

 tat gat aca gca gtg ttc gag ttg ata cag cta gtt cca cca gtg ggt      346
 Tyr Asp Thr Ala Val Phe Glu Leu Ile Gln Leu Val Pro Pro Val Gly
  80                  85                  90                  95

 gaa aca ctg tct acg tat gac gaa aat aca cga gat ttc atg ttt ccg      394
 Glu Thr Leu Ser Thr Tyr Asp Glu Asn Thr Arg Asp Phe Met Phe Pro
                 100                 105                 110

 ggt cca aac caa atg tct gga cac cat gat tca aac cgc cag gtt acc      442
 Gly Pro Asn Gln Met Ser Gly His His Asp Ser Asn Arg Gln Val Thr
             115                 120                 125

 atg agg agg att tct ggc ctt cga gga aat gct cca agg ctg gaa ttt      490
 Met Arg Arg Ile Ser Gly Leu Arg Gly Asn Ala Pro Arg Leu Glu Phe
         130                 135                 140

 tct acg act tca gtg att act gaa tgt ctg ata agt tca agg aaa tgc      538
 Ser Thr Thr Ser Val Ile Thr Glu Cys Leu Ile Ser Ser Arg Lys Cys
     145                 150                 155

 cac act cag gat aaa ttt att tac cat ttg gct cca gtt gaa aaa tca      586
 His Thr Gln Asp Lys Phe Ile Tyr His Leu Ala Pro Val Glu Lys Ser
 160                 165                 170                 175

 cat ggc aga ctg caa aac aga aca tca aga tca caa aag aaa aaa tcc      634
 His Gly Arg Leu Gln Asn Arg Thr Ser Arg Ser Gln Lys Lys Lys Ser
                 180                 185                 190

 aag tca cct gag aga agt aaa tac tgt ata aat gca aaa aac tac gaa      682
 Lys Ser Pro Glu Arg Ser Lys Tyr Cys Ile Asn Ala Lys Asn Tyr Glu
             195                 200                 205

 cag cct aca att tct tca aaa tca cac tct cca tct ccc tac aca aaa      730
 Gln Pro Thr Ile Ser Ser Lys Ser His Ser Pro Ser Pro Tyr Thr Lys
         210                 215                 220

 aga cgc atg tgt gag cta tct gaa gac acc agg cgg cgg ctg gcc cat      778
 Arg Arg Met Cys Glu Leu Ser Glu Asp Thr Arg Arg Arg Leu Ala His
     225                 230                 235

 tta aat ctg gga ccc tat gag ttc aaa aaa gaa aca gat aaa cct cca      826
 Leu Asn Leu Gly Pro Tyr Glu Phe Lys Lys Glu Thr Asp Lys Pro Pro
 240                 245                 250                 255

 ttt gtg att aga cat gtt gat ccc cca agt ccc agg gct gat act tta      874
 Phe Val Ile Arg His Val Asp Pro Pro Ser Pro Arg Ala Asp Thr Leu
                 260                 265                 270

 ttg gga tct tct gga aga gac tgt gaa aga gat gga tgg tca agg gtg      922
 Leu Gly Ser Ser Gly Arg Asp Cys Glu Arg Asp Gly Trp Ser Arg Val
             275                 280                 285

 cac aat gat cat tct cat ctt ggc tgc tgc cga ccc aag gat tat aag      970
 His Asn Asp His Ser His Leu Gly Cys Cys Arg Pro Lys Asp Tyr Lys
         290                 295                 300

 gtt atc agg aca ccc cat ggg aga gac ttc gat gac tct tta gaa aaa     1018
 Val Ile Arg Thr Pro His Gly Arg Asp Phe Asp Asp Ser Leu Glu Lys
     305                 310                 315

 tgt gaa gag tat ttg agc cca agg tcg tgt agt aag ccc cgg cat tca     1066
 Cys Glu Glu Tyr Leu Ser Pro Arg Ser Cys Ser Lys Pro Arg His Ser
 320                 325                 330                 335

 gcg agg acc ttg cta gtc cat tca gca ccc tca aca atg cca aag cat     1114
 Ala Arg Thr Leu Leu Val His Ser Ala Pro Ser Thr Met Pro Lys His
                 340                 345                 350

 tct cca agc cct gtg tta aat aga gct tct ctc agg gaa aga ttt cat     1162
 Ser Pro Ser Pro Val Leu Asn Arg Ala Ser Leu Arg Glu Arg Phe His
             355                 360                 365

 tct gat tgg tgt tca cct tca aac tgc gat gag atc cat gac cgg gta     1210
 Ser Asp Trp Cys Ser Pro Ser Asn Cys Asp Glu Ile His Asp Arg Val
         370                 375                 380

 aaa aat gtc ttg aaa tca cat cag gct cat caa aga cat tta tat gat     1258
 Lys Asn Val Leu Lys Ser His Gln Ala His Gln Arg His Leu Tyr Asp
     385                 390                 395

 gag aga gac cta gag aaa gat gat gaa ctg gaa ctg aaa aga agt ctt     1306
 Glu Arg Asp Leu Glu Lys Asp Asp Glu Leu Glu Leu Lys Arg Ser Leu
 400                 405                 410                 415

 tta tgt aga gac tct gcc tat gac agt gac ccc gag tat agc tca tgt     1354
 Leu Cys Arg Asp Ser Ala Tyr Asp Ser Asp Pro Glu Tyr Ser Ser Cys
                 420                 425                 430

 cag cag cca cgt ggc act ttc cat ttg gat gac ggt gaa tac tgg tcc     1402
 Gln Gln Pro Arg Gly Thr Phe His Leu Asp Asp Gly Glu Tyr Trp Ser
             435                 440                 445

 aac agg gca gcc tct tat aag gga aaa tcc cac cga ccc atc ttt gag     1450
 Asn Arg Ala Ala Ser Tyr Lys Gly Lys Ser His Arg Pro Ile Phe Glu
         450                 455                 460

 aac agc atg gac aag atg tac agg aac tta tac aaa aag gcc tgt agt     1498
 Asn Ser Met Asp Lys Met Tyr Arg Asn Leu Tyr Lys Lys Ala Cys Ser
     465                 470                 475

 tct gct tca cat aca cag gaa agc ttc tga                             1528
 Ser Ala Ser His Thr Gln Glu Ser Phe 
 480                 485





      <210> 49
      <211> 2482
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (571)..(2019)

      <400> 49
 atggttcctc caaagctgca ggaggccttt gaacctttcg atttgaaaca tgctggtgca     60

 cacttcagag ctccgcccag agaatccctc gaccaccggg agaaccgagt ctttcgggga    120

 tttgcccctc cagacaagag aaatgagcaa gcagggagct catcagctgt tgttagtgta    180

 ttttacgtgt gtggtatggc ccaatacagt tcgtcttctt ccagtgtggc tcagggaagc    240

 cgaaaggttg aaaatgtccg cttggtagat cgagtgtctc ctaaaaaagc agctctaggt    300

 actttgtatt tgacggctac ccatgtcata ttcgtggaaa attcacctga cgcaagaaaa    360

 gaaacatgga ttcttcacag tcagatttcc accattgaga aacaggcaac aaccgctacc    420

 ggatgccctc tgctgattcg ctgcaagaac tttcagataa tacagctcat catacctcag    480

 gaaagagatt gccacgacgt gtacatctcc ctgatacgcc ttgcaaggcc agtgaaatat    540

 gaggagttat actgcttttc attcaacccc     atg ctg gat aaa gaa gaa aga     591
                                      Met Leu Asp Lys Glu Glu Arg
                                        1               5

 gag caa ggc tgg gtg ctg atc gat ctt agt gaa gaa tac acg cgg atg      639
 Glu Gln Gly Trp Val Leu Ile Asp Leu Ser Glu Glu Tyr Thr Arg Met
          10                  15                  20

 ggc ctc cct aat cat tac tgg cag ctc agc gat gtg aat aga gac tat      687
 Gly Leu Pro Asn His Tyr Trp Gln Leu Ser Asp Val Asn Arg Asp Tyr
      25                  30                  35

 aga ttt tct att ctg cta aca aag aca gtg gag gtc agc aag gga ggc      735
 Arg Phe Ser Ile Leu Leu Thr Lys Thr Val Glu Val Ser Lys Gly Gly
  40                  45                  50                  55

 atc atc aca gaa gac ttt ata aga ggc ttg gat ttc agt tgt ggg ttt      783
 Ile Ile Thr Glu Asp Phe Ile Arg Gly Leu Asp Phe Ser Cys Gly Phe
                  60                  65                  70

 tca acc cct aca acc cca tct tcc aga gtg ata aag gtc tgt gac tct      831
 Ser Thr Pro Thr Thr Pro Ser Ser Arg Val Ile Lys Val Cys Asp Ser
              75                  80                  85

 tat cct act gaa ctg tac gtt ccc aaa tcg gcc acg gca cac atc ata      879
 Tyr Pro Thr Glu Leu Tyr Val Pro Lys Ser Ala Thr Ala His Ile Ile
          90                  95                 100

 gtg ggg agt tcc aaa ttc cgg agt aga cgg cga ttt cct gtc ctt tct      927
 Val Gly Ser Ser Lys Phe Arg Ser Arg Arg Arg Phe Pro Val Leu Ser
     105                 110                 115

 tac tat tat aaa gat aac cac gcc tcc atc tgc cgg agc agc cag ccc      975
 Tyr Tyr Tyr Lys Asp Asn His Ala Ser Ile Cys Arg Ser Ser Gln Pro
 120                 125                 130                 135

 ctg tcc ggc ttc agt gcc cgg tgc cta gag gac gag cag atg ctc cag     1023
 Leu Ser Gly Phe Ser Ala Arg Cys Leu Glu Asp Glu Gln Met Leu Gln
                 140                 145                 150

 gcc att agg aaa gcc aat cca gga agt gac ttc gtt tat gtc gtt gac     1071
 Ala Ile Arg Lys Ala Asn Pro Gly Ser Asp Phe Val Tyr Val Val Asp
             155                 160                 165

 acc cgg cct aaa ctt aat gca atg gca aat cgt gct gca ggg aaa ggc     1119
 Thr Arg Pro Lys Leu Asn Ala Met Ala Asn Arg Ala Ala Gly Lys Gly
         170                 175                 180

 tat gag aat gaa gac aat tat tcc aat atc aag ttt cag ttt atc ggg     1167
 Tyr Glu Asn Glu Asp Asn Tyr Ser Asn Ile Lys Phe Gln Phe Ile Gly
     185                 190                 195

 ata gag aac atc cat gtc atg agg aac agt ctg cag aaa atg ctg gaa     1215
 Ile Glu Asn Ile His Val Met Arg Asn Ser Leu Gln Lys Met Leu Glu
 200                 205                 210                 215

 gtg tgt gaa ctt aaa tct ccc tcc atg agt gat ttc ctg tgg ggt ctg     1263
 Val Cys Glu Leu Lys Ser Pro Ser Met Ser Asp Phe Leu Trp Gly Leu
                 220                 225                 230

 gag aac tct ggc tgg tta agg cac att aaa gcc ata atg gat gca gga     1311
 Glu Asn Ser Gly Trp Leu Arg His Ile Lys Ala Ile Met Asp Ala Gly
             235                 240                 245

 atc ttc att gca aag gca gtg tca gag gaa ggg gca agt gtg ctt gtt     1359
 Ile Phe Ile Ala Lys Ala Val Ser Glu Glu Gly Ala Ser Val Leu Val
         250                 255                 260

 cac tgt tct gat ggc tgg gac agg acc gct cag gtg tgc tcg gtg gca     1407
 His Cys Ser Asp Gly Trp Asp Arg Thr Ala Gln Val Cys Ser Val Ala
     265                 270                 275

 agc ctg ctg ctg gac cct cac tac cgg act ctg aag ggc ttc atg gta     1455
 Ser Leu Leu Leu Asp Pro His Tyr Arg Thr Leu Lys Gly Phe Met Val
 280                 285                 290                 295

 tta att gaa aag gac tgg att tcc ttt ggt cat aag ttt aat cac cga     1503
 Leu Ile Glu Lys Asp Trp Ile Ser Phe Gly His Lys Phe Asn His Arg
                 300                 305                 310

 tat ggc aat cta gat ggt gac cca aaa gaa atc tct cca gtt att gac     1551
 Tyr Gly Asn Leu Asp Gly Asp Pro Lys Glu Ile Ser Pro Val Ile Asp
             315                 320                 325

 cag ttc att gag tgt gtt tgg cag tta atg gaa caa ttt ccc tgt gcc     1599
 Gln Phe Ile Glu Cys Val Trp Gln Leu Met Glu Gln Phe Pro Cys Ala
         330                 335                 340

 ttt gag ttc aat gag agg ttt ttg att cac att caa cat cac att tat     1647
 Phe Glu Phe Asn Glu Arg Phe Leu Ile His Ile Gln His His Ile Tyr
     345                 350                 355

 tcc tgc cag ttt gga aac ttc cta tgt aac agc caa aag gag aga cga     1695
 Ser Cys Gln Phe Gly Asn Phe Leu Cys Asn Ser Gln Lys Glu Arg Arg
 360                 365                 370                 375

 gaa ctc aag att caa gaa aga aca tac tca tta tgg gct cac ctg tgg     1743
 Glu Leu Lys Ile Gln Glu Arg Thr Tyr Ser Leu Trp Ala His Leu Trp
                 380                 385                 390

 aag aat cgg gcc gat aac ctg aat ctt ctg ttt aga gct gat cac agc     1791
 Lys Asn Arg Ala Asp Asn Leu Asn Leu Leu Phe Arg Ala Asp His Ser
             395                 400                 405

 cag act cag gga acc ttt cat ctc cct aca aca cca tgt aac ttc atg     1839
 Gln Thr Gln Gly Thr Phe His Leu Pro Thr Thr Pro Cys Asn Phe Met
         410                 415                 420

 tac aag ttt tgg agt gga atg tat aac cgc ttt gaa aag ggg atg cag     1887
 Tyr Lys Phe Trp Ser Gly Met Tyr Asn Arg Phe Glu Lys Gly Met Gln
     425                 430                 435

 ccc cga cag tca gtt aca gat tac cta atg gca gtg aag gaa gaa act     1935
 Pro Arg Gln Ser Val Thr Asp Tyr Leu Met Ala Val Lys Glu Glu Thr
 440                 445                 450                 455

 cag cag cta gag gaa gaa cta gag gcc ctg gaa gaa gta aga cat act     1983
 Gln Gln Leu Glu Glu Glu Leu Glu Ala Leu Glu Glu Val Arg His Thr
                 460                 465                 470

 tgc ttt gtt aat cta ttt tct gtg ctt att tct tga agag caaggcttca     2033
 Cys Phe Val Asn Leu Phe Ser Val Leu Ile Ser 
             475                 480

 tgaaagcctc ttaagattca gtgcaataca aatatttcac atttttagtc agtagaacac   2093

 ctgaaacaca accccatcca ggtcaggact cagataaccg aagcccaaac ctaggcattt   2153

 aatgcatttc acacatctgg tttgtggctc agttccacaa atttttggtt gttccttatt   2213

 ttaggtcaac ttgtttggtt actgttattt gagagtagta aaattaattt ttttctggaa   2273

 agtgtgaaaa agtaacagaa taaaatcaaa tatatgtact tgtaaaactc tttccccact   2333

 tttagaaatt atgttaacta tgatattaat ctataattgg taaaggggag actgactgta   2393

 aagtcttatc ttttggcttc tatgaacttc cctgtacttg gacagggagg ttataataaa   2453

 atgcttttcc taattggaaa aaaaaaaaa                                     2482




      <210> 50
      <211> 2246
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (110)..(1891)

      <400> 50
 acctgcggta ccgctccgga attcccgggt cgacgatttc gtgcggagcc cggcccgaga     60

 gccgcgtcca cgttcctgcc tcctgctccc gccgccctgg ggcgccgcc    atg acg     115
                                                          Met Thr
                                                            1

 ccc gat ctg ctc aac ttc aag aag gga tgg atg tcg atc ttg gac gag      163
 Pro Asp Leu Leu Asn Phe Lys Lys Gly Trp Met Ser Ile Leu Asp Glu
           5                  10                  15

 cct gga gag cct ccc tcc ccc tcg ctc acc acc acc tct act tcg cag      211
 Pro Gly Glu Pro Pro Ser Pro Ser Leu Thr Thr Thr Ser Thr Ser Gln
      20                  25                  30

 tgg aag aaa cat tgg ttt gtg ctg aca gat tca agt ctc aaa tat tac      259
 Trp Lys Lys His Trp Phe Val Leu Thr Asp Ser Ser Leu Lys Tyr Tyr
  35                  40                  45                  50

 aga gac tcc act gct gag gag gca gat gag ctg gat ggt gag atc gac      307
 Arg Asp Ser Thr Ala Glu Glu Ala Asp Glu Leu Asp Gly Glu Ile Asp
                  55                  60                  65

 ctg cgt tcc tgc acg gat gtc act gag tac gcg gtg cag cgc aac tat      355
 Leu Arg Ser Cys Thr Asp Val Thr Glu Tyr Ala Val Gln Arg Asn Tyr
              70                  75                  80

 ggc ttc cag atc cac acc aag gat gct gtc tat acc ttg tcg gcc atg      403
 Gly Phe Gln Ile His Thr Lys Asp Ala Val Tyr Thr Leu Ser Ala Met
          85                  90                  95

 acc tca ggc atc cgg cgg aac tgg atc gag gct ctg aga aag acc gta      451
 Thr Ser Gly Ile Arg Arg Asn Trp Ile Glu Ala Leu Arg Lys Thr Val
     100                 105                 110

 cgt cca act tca gcc cca gat gtc acc aag ctc tcg gac tct aac aag      499
 Arg Pro Thr Ser Ala Pro Asp Val Thr Lys Leu Ser Asp Ser Asn Lys
 115                 120                 125                 130

 gag aac gcg ctg cac agc tac agc acc cag aag ggc ccc ctg aag gca      547
 Glu Asn Ala Leu His Ser Tyr Ser Thr Gln Lys Gly Pro Leu Lys Ala
                 135                 140                 145

 ggg gag cag cgg gcg ggc tct gag gtc atc agc cgg ggt ggc cct cgg      595
 Gly Glu Gln Arg Ala Gly Ser Glu Val Ile Ser Arg Gly Gly Pro Arg
             150                 155                 160

 aag gcg gac ggg cag cgt cag gcc ttg gac tac gtg gag ctc tcg ccg      643
 Lys Ala Asp Gly Gln Arg Gln Ala Leu Asp Tyr Val Glu Leu Ser Pro
         165                 170                 175

 ctg acc cag gct tcc ccg cag cgg gcc cgc acc cca gcc cgc act cct      691
 Leu Thr Gln Ala Ser Pro Gln Arg Ala Arg Thr Pro Ala Arg Thr Pro
     180                 185                 190

 gac cgc ctg gcc aag cag gag gag ctg gag cgg gac ctg gcc cag cgc      739
 Asp Arg Leu Ala Lys Gln Glu Glu Leu Glu Arg Asp Leu Ala Gln Arg
 195                 200                 205                 210

 tcc gag gag cgg cgc aag tgg ttt gag gcc aca gac agc agg acc cca      787
 Ser Glu Glu Arg Arg Lys Trp Phe Glu Ala Thr Asp Ser Arg Thr Pro
                 215                 220                 225

 gag gtg cct gct ggt gag ggg ccg cgc cgg ggc ctg ggt gcc ccc ctg      835
 Glu Val Pro Ala Gly Glu Gly Pro Arg Arg Gly Leu Gly Ala Pro Leu
             230                 235                 240

 act gag gac cag caa aac cgg ctt agt gag gag atc gag aag aag tgg      883
 Thr Glu Asp Gln Gln Asn Arg Leu Ser Glu Glu Ile Glu Lys Lys Trp
         245                 250                 255

 cag gag ctg gag aag ctg ccc ctg cgg gag aat aag cgg gtg ccc ctc      931
 Gln Glu Leu Glu Lys Leu Pro Leu Arg Glu Asn Lys Arg Val Pro Leu
     260                 265                 270

 act gcc ctg ctc aac caa agc cgc gga gag cgc cga ggg ccc cca agt      979
 Thr Ala Leu Leu Asn Gln Ser Arg Gly Glu Arg Arg Gly Pro Pro Ser
 275                 280                 285                 290

 gac ggc cac gag gca ctg gag aag gag gtt cag gct ctt cgg gcc cag     1027
 Asp Gly His Glu Ala Leu Glu Lys Glu Val Gln Ala Leu Arg Ala Gln
                 295                 300                 305

 ctg gag gcg tgg cgt ctc caa ggg gag gct cct cag agt gca ctg aga     1075
 Leu Glu Ala Trp Arg Leu Gln Gly Glu Ala Pro Gln Ser Ala Leu Arg
             310                 315                 320

 tcc cag gag gat ggc cac atc ccc ccg ggc tac atc tca cag gag gca     1123
 Ser Gln Glu Asp Gly His Ile Pro Pro Gly Tyr Ile Ser Gln Glu Ala
         325                 330                 335

 tgt gag cgc agc ctg gca gag atg gag tcc tcg cac cag cag gtg atg     1171
 Cys Glu Arg Ser Leu Ala Glu Met Glu Ser Ser His Gln Gln Val Met
     340                 345                 350

 gag gag ctg cag cgg cac cac gag cgg gag ctg cag cgc ctg cag cag     1219
 Glu Glu Leu Gln Arg His His Glu Arg Glu Leu Gln Arg Leu Gln Gln
 355                 360                 365                 370

 gag aag gag tgg ctc ctg gct gag gag acg gca gcc acg gcc tca gcc     1267
 Glu Lys Glu Trp Leu Leu Ala Glu Glu Thr Ala Ala Thr Ala Ser Ala
                 375                 380                 385

 att gaa gcc atg aag aag gcc tac cag gaa gag ctg agc cga gag ctg     1315
 Ile Glu Ala Met Lys Lys Ala Tyr Gln Glu Glu Leu Ser Arg Glu Leu
             390                 395                 400

 agc aaa aca cgg agt ctc cag cag ggc ccg gat ggc ctc cgg aag cag     1363
 Ser Lys Thr Arg Ser Leu Gln Gln Gly Pro Asp Gly Leu Arg Lys Gln
         405                 410                 415

 cac cag tca gat gtg gag gca ctg aag cga gag ctg cag gtg cta tcg     1411
 His Gln Ser Asp Val Glu Ala Leu Lys Arg Glu Leu Gln Val Leu Ser
     420                 425                 430

 gag cag tac tcg cag aag tgc ctg gag att ggg gca ctc atg cgg cag     1459
 Glu Gln Tyr Ser Gln Lys Cys Leu Glu Ile Gly Ala Leu Met Arg Gln
 435                 440                 445                 450

 gct gag gag cgc gag cac acg ctg cgc cgc tgc cag cag gag ggc cag     1507
 Ala Glu Glu Arg Glu His Thr Leu Arg Arg Cys Gln Gln Glu Gly Gln
                 455                 460                 465

 gag ctg ctg cgc cac aac cag gag ctg cat ggc cgc ctg tca gag gag     1555
 Glu Leu Leu Arg His Asn Gln Glu Leu His Gly Arg Leu Ser Glu Glu
             470                 475                 480

 ata gac cag ctg cgc ggc ttc att gcc tcg cag ggc atg ggc aat ggc     1603
 Ile Asp Gln Leu Arg Gly Phe Ile Ala Ser Gln Gly Met Gly Asn Gly
         485                 490                 495

 tgc ggg cgc agc aac gag cgg agt tcc tgc gag cta gag gtg ctg ctt     1651
 Cys Gly Arg Ser Asn Glu Arg Ser Ser Cys Glu Leu Glu Val Leu Leu
     500                 505                 510

 cgc gta aaa gaa aac gaa ctc cag tac cta aag aag gag gtg cag tgc     1699
 Arg Val Lys Glu Asn Glu Leu Gln Tyr Leu Lys Lys Glu Val Gln Cys
 515                 520                 525                 530

 ctc cgg gac gag ctc cag atg atg cag aag gac aag cgc ttc acc tcg     1747
 Leu Arg Asp Glu Leu Gln Met Met Gln Lys Asp Lys Arg Phe Thr Ser
                 535                 540                 545

 gga aag tac cag gac gtc tat gtg gag ctg agc cac atc aag aca cgg     1795
 Gly Lys Tyr Gln Asp Val Tyr Val Glu Leu Ser His Ile Lys Thr Arg
             550                 555                 560

 tct gag cgg gag atc gag cag ctg aag gag cac ctg cgt ctt gcc atg     1843
 Ser Glu Arg Glu Ile Glu Gln Leu Lys Glu His Leu Arg Leu Ala Met
         565                 570                 575

 gcc gcc ctc cag gag aag gag tcg atg cgc aac agc ctg gct gag tag     1891
 Ala Ala Leu Gln Glu Lys Glu Ser Met Arg Asn Ser Leu Ala Glu 
     580                 585                 590

 aggtcccgcc cagctgcaga ccctccaggc tggaggacca gccgccctcc ttccctcctg   1951

 gatggaagta aaaagccaag ctttctcccc accctctgtg ggccacacgt gcacttgcac   2011

 ccaccacaca cacacacaca cacacacaca cacacacaga cacacagaca catacgcaca   2071

 cacgtgcaca catgtacaca cggatacaca cacacacaca cacactgcat atctgagcgc   2131

 gcccctcgca ctgggtctca ccttgcacct tcttcaggat tttatatgtg aagagatttt   2191

 tatatagatt tttttccttt ttttccaaaa cactttatac tttaaaaaaa aaaaa        2246




      <210> 51
      <211> 3759
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (199)..(2475)

      <400> 51
 ggcacgagcg gcacgatcca ccgacgacct cactcagctg cgttacgcgc cgctccggct     60

 gccggccgcg cgccttgccc gccggctccc gcccgcaatc ggcggctcag ggcggacccg    120

 ggtctctgcg ttctcgcgag aagcgcggcg ctgcggggcc gtgggcgcct gagcccgcgc    180

 ggccctcgag ggccgaat  atg ggg gga tgc acg gtg aag cct cag ctg ctg     231
                      Met Gly Gly Cys Thr Val Lys Pro Gln Leu Leu
                        1               5                  10

 ctc ctg gcg ctc gtc ctc cac ccc tgg aat ccc tgt ctg ggt gcg gac      279
 Leu Leu Ala Leu Val Leu His Pro Trp Asn Pro Cys Leu Gly Ala Asp
              15                  20                  25

 tcg gag aag ccc tcg agc atc ccc aca gat aaa tta tta gtc ata act      327
 Ser Glu Lys Pro Ser Ser Ile Pro Thr Asp Lys Leu Leu Val Ile Thr
          30                  35                  40

 gta gca aca aaa gaa agt gat gga ttc cat cga ttt atg cag tca gcc      375
 Val Ala Thr Lys Glu Ser Asp Gly Phe His Arg Phe Met Gln Ser Ala
      45                  50                  55

 aaa tat ttc aat tat act gtg aag gtc ctt ggt caa gga gaa gaa tgg      423
 Lys Tyr Phe Asn Tyr Thr Val Lys Val Leu Gly Gln Gly Glu Glu Trp
  60                  65                  70                  75

 aga ggt ggt gat gga att aat agt att gga ggg ggc cag aaa gtg aga      471
 Arg Gly Gly Asp Gly Ile Asn Ser Ile Gly Gly Gly Gln Lys Val Arg
                  80                  85                  90

 tta atg aaa gaa gtc atg gaa cac tat gct gat caa gat gat ctg gtt      519
 Leu Met Lys Glu Val Met Glu His Tyr Ala Asp Gln Asp Asp Leu Val
              95                 100                 105

 gtc atg ttt act gaa tgc ttt gat gtc ata ttt gct ggt ggt cca gaa      567
 Val Met Phe Thr Glu Cys Phe Asp Val Ile Phe Ala Gly Gly Pro Glu
         110                 115                 120

 gaa gtt cta aaa aaa ttc caa aag gca aac cac aaa gtg gtc ttt gca      615
 Glu Val Leu Lys Lys Phe Gln Lys Ala Asn His Lys Val Val Phe Ala
     125                 130                 135

 gca gat gga att ttg tgg cca gat aaa aga cta gca gac aag tat cct      663
 Ala Asp Gly Ile Leu Trp Pro Asp Lys Arg Leu Ala Asp Lys Tyr Pro
 140                 145                 150                 155

 gtt gtg cac att ggg aaa cgc tat ctg aat tca gga gga ttt att ggc      711
 Val Val His Ile Gly Lys Arg Tyr Leu Asn Ser Gly Gly Phe Ile Gly
                 160                 165                 170

 tat gct cca tat gtc aac cgt ata gtt caa caa tgg aat ctc cag gat      759
 Tyr Ala Pro Tyr Val Asn Arg Ile Val Gln Gln Trp Asn Leu Gln Asp
             175                 180                 185

 aat gat gat gat cag ctc ttt tac act aaa gtt tac att gat cca ctg      807
 Asn Asp Asp Asp Gln Leu Phe Tyr Thr Lys Val Tyr Ile Asp Pro Leu
         190                 195                 200

 aaa agg gaa gct att aac atc aca ttg gat cac aaa tgc aaa att ttc      855
 Lys Arg Glu Ala Ile Asn Ile Thr Leu Asp His Lys Cys Lys Ile Phe
     205                 210                 215

 cag acc tta aat gga gct gta gat gaa gtt gtt tta aaa ttt gaa aat      903
 Gln Thr Leu Asn Gly Ala Val Asp Glu Val Val Leu Lys Phe Glu Asn
 220                 225                 230                 235

 ggc aaa gcc aga gct aag aat aca ttt tat gaa aca tta cca gtg gca      951
 Gly Lys Ala Arg Ala Lys Asn Thr Phe Tyr Glu Thr Leu Pro Val Ala
                 240                 245                 250

 att aat gga aat gga ccc acc aag att ctc ctg aat tat ttt gga aac      999
 Ile Asn Gly Asn Gly Pro Thr Lys Ile Leu Leu Asn Tyr Phe Gly Asn
             255                 260                 265

 tat gta ccc aat tca tgg aca cag gat aat ggc tgc act ctt tgt gaa     1047
 Tyr Val Pro Asn Ser Trp Thr Gln Asp Asn Gly Cys Thr Leu Cys Glu
         270                 275                 280

 ttc gat aca gtc gac ttg tct gca gta gat gtc cat cca aac gta tca     1095
 Phe Asp Thr Val Asp Leu Ser Ala Val Asp Val His Pro Asn Val Ser
     285                 290                 295

 ata ggt gtt ttt att gag caa cca acc cct ttt cta cct cgg ttt ctg     1143
 Ile Gly Val Phe Ile Glu Gln Pro Thr Pro Phe Leu Pro Arg Phe Leu
 300                 305                 310                 315

 gac ata ttg ttg aca ctg gat tac cca aaa gaa gca ctt aaa ctt ttt     1191
 Asp Ile Leu Leu Thr Leu Asp Tyr Pro Lys Glu Ala Leu Lys Leu Phe
                 320                 325                 330

 att cat aac aaa gaa gtt tat cat gaa aag gac atc aag gta ttt ttt     1239
 Ile His Asn Lys Glu Val Tyr His Glu Lys Asp Ile Lys Val Phe Phe
             335                 340                 345

 gat aaa gct aag cat gaa atc aaa act ata aaa ata gta gga cca gaa     1287
 Asp Lys Ala Lys His Glu Ile Lys Thr Ile Lys Ile Val Gly Pro Glu
         350                 355                 360

 gaa aat cta agt caa gcg gaa gcc aga aac atg gga atg gac ttt tgc     1335
 Glu Asn Leu Ser Gln Ala Glu Ala Arg Asn Met Gly Met Asp Phe Cys
     365                 370                 375

 cgt cag gat gaa aag tgt gat tat tac ttt agt gtg gat gca gat gtt     1383
 Arg Gln Asp Glu Lys Cys Asp Tyr Tyr Phe Ser Val Asp Ala Asp Val
 380                 385                 390                 395

 gtt ttg aca aat cca agg act tta aaa att ttg att gaa caa aac aga     1431
 Val Leu Thr Asn Pro Arg Thr Leu Lys Ile Leu Ile Glu Gln Asn Arg
                 400                 405                 410

 aag atc att gct cct ctt gta act cgt cat gga aag ctg tgg tcc aat     1479
 Lys Ile Ile Ala Pro Leu Val Thr Arg His Gly Lys Leu Trp Ser Asn
             415                 420                 425

 ttc tgg gga gca ttg agt cct gat gga tac tat gca cga tct gaa gat     1527
 Phe Trp Gly Ala Leu Ser Pro Asp Gly Tyr Tyr Ala Arg Ser Glu Asp
         430                 435                 440

 tat gtg gat att gtt caa ggg aat aga gta gga gta tgg aat gtc cca     1575
 Tyr Val Asp Ile Val Gln Gly Asn Arg Val Gly Val Trp Asn Val Pro
     445                 450                 455

 tat atg gct aat gtg tac tta att aaa gga aag aca ctc cga tca gag     1623
 Tyr Met Ala Asn Val Tyr Leu Ile Lys Gly Lys Thr Leu Arg Ser Glu
 460                 465                 470                 475

 atg aat gaa agg aac tat ttt gtt cgt gat aaa ctg gat cct gat atg     1671
 Met Asn Glu Arg Asn Tyr Phe Val Arg Asp Lys Leu Asp Pro Asp Met
                 480                 485                 490

 gct ctt tgc cga aat gct aga gaa atg act tta caa agg gaa aaa gac     1719
 Ala Leu Cys Arg Asn Ala Arg Glu Met Thr Leu Gln Arg Glu Lys Asp
             495                 500                 505

 tcc cct act ccg gaa aca ttc caa atg ctc agc ccc cca aag ggt gta     1767
 Ser Pro Thr Pro Glu Thr Phe Gln Met Leu Ser Pro Pro Lys Gly Val
         510                 515                 520

 ttt atg tac att tct aat aga cat gaa ttt gga agg cta tta tcc act     1815
 Phe Met Tyr Ile Ser Asn Arg His Glu Phe Gly Arg Leu Leu Ser Thr
     525                 530                 535

 gct aat tac aat act tcc cat tat aac aat gac ctc tgg cag att ttt     1863
 Ala Asn Tyr Asn Thr Ser His Tyr Asn Asn Asp Leu Trp Gln Ile Phe
 540                 545                 550                 555

 gaa aat cct gtg gac tgg aag gaa aag tat ata aac cgt gat tat tca     1911
 Glu Asn Pro Val Asp Trp Lys Glu Lys Tyr Ile Asn Arg Asp Tyr Ser
                 560                 565                 570

 aag att ttc act gaa aat ata gtt gaa cag ccc tgt cca gat gtc ttt     1959
 Lys Ile Phe Thr Glu Asn Ile Val Glu Gln Pro Cys Pro Asp Val Phe
             575                 580                 585

 tgg ttc ccc ata ttt tct gaa aaa gcc tgt gat gaa ttg gta gaa gaa     2007
 Trp Phe Pro Ile Phe Ser Glu Lys Ala Cys Asp Glu Leu Val Glu Glu
         590                 595                 600

 atg gaa cat tac ggc aaa tgg tct ggg gga aaa cat cat gat agc cgt     2055
 Met Glu His Tyr Gly Lys Trp Ser Gly Gly Lys His His Asp Ser Arg
     605                 610                 615

 ata tct ggt ggt tat gaa aat gtc cca act gat gat atc cac atg aag     2103
 Ile Ser Gly Gly Tyr Glu Asn Val Pro Thr Asp Asp Ile His Met Lys
 620                 625                 630                 635

 caa gtt gat ctg gag aat gta tgg ctt cat ttt atc cgg gag ttc att     2151
 Gln Val Asp Leu Glu Asn Val Trp Leu His Phe Ile Arg Glu Phe Ile
                 640                 645                 650

 gca cca gtt aca ctg aag gtc ttt gca ggc tat tat acg aag gga ttt     2199
 Ala Pro Val Thr Leu Lys Val Phe Ala Gly Tyr Tyr Thr Lys Gly Phe
             655                 660                 665

 gca cta ctg aat ttt gta gta aaa tac tcc cct gaa cga cag cgt tct     2247
 Ala Leu Leu Asn Phe Val Val Lys Tyr Ser Pro Glu Arg Gln Arg Ser
         670                 675                 680

 ctt cgt cct cat cat gat gct tct aca ttt acc ata aac att gca ctt     2295
 Leu Arg Pro His His Asp Ala Ser Thr Phe Thr Ile Asn Ile Ala Leu
     685                 690                 695

 aat aac gtg gga gaa gac ttt cag gga ggt ggt tgc aaa ttt cta agg     2343
 Asn Asn Val Gly Glu Asp Phe Gln Gly Gly Gly Cys Lys Phe Leu Arg
 700                 705                 710                 715

 tac aat tgc tct att gag tca cca cga aaa ggc tgg agc ttc atg cat     2391
 Tyr Asn Cys Ser Ile Glu Ser Pro Arg Lys Gly Trp Ser Phe Met His
                 720                 725                 730

 cct ggg aga ctc aca cat ttg cat gaa gga ctt cct gtt aaa aat gga     2439
 Pro Gly Arg Leu Thr His Leu His Glu Gly Leu Pro Val Lys Asn Gly
             735                 740                 745

 aca aga tac att gca gtg tca ttt ata gat ccc taa gtta tttacttttc     2489
 Thr Arg Tyr Ile Ala Val Ser Phe Ile Asp Pro 
         750                 755

 attgaattga aatttatttt gggtgaatga ctggcatgaa cacgtctttg aagttgtggc   2549

 tgagaagatg agaggaatat ttaaataaca tcaacagaac aacttcactt tgggccaaac   2609

 atttgaaaaa ctttttataa aaaattgttt gatatttctt aatgtctgct ctgagcctta   2669

 aaacacagat tgaagaagaa aagaaagaaa aaacttaaat atttatttct atgctttgtt   2729

 gcctctgaga ataatgacaa tttatgaatt tgtgtttcaa attgataaaa tatttaggta   2789

 caaataacaa gactaataat attttcttat ttttaaaaag catgggaaga tttttattta   2849

 tcaaaatata gaggaaatgt agacaaaatg gatataaatg aaaattacca tgttgtaaaa   2909

 ccttgaaaat cagattctaa ctggatttgt atgcaactaa gtatttttct gaacacctat   2969

 gcaggtctta tttacagtag ttactaaggg aacacacaaa gaattacaca acgttttcct   3029

 caagaaaatg gtacaaaaca caaccgagga gcgtatacag ttgaaaacat ttttgttttg   3089

 attggaaggc agattatttt atattagtat taaaaatcaa accctatgtt tctttcagat   3149

 gaatcttcca aagtggatta tattaagcag gtattagatt taggaaaacc tttccatttc   3209

 ttaaagtatt atcaagtgtc aagatcagca agtgtcctta agtcaaacag gttttttttg   3269

 ttgttgtttt tgctttgttt ccttttttag aaagttctag aaaataggaa aacgaaaaat   3329

 ttcattgaga tgagtagtgc atttaattat tttttaaaaa actttttaag tacttgaatt   3389

 ttatatcagg aaaacaaagt tgttgagcct tgcttcttcc gttttgccct ttgtctcgct   3449

 ccttattctt tttttggggg gagggttatt tgctttttta tcttcctggc ataatttcca   3509

 ttttattctt ctgagtgtct atgttaactt ccctctatcc cgcttataaa aaaattctcc   3569

 aacaaaaata cttgttgact tgatgtttta tcacttctct aagtaaggtt gaaatatcct   3629

 tattgtagct actgttttta atgtaaaggt taaacttgaa aagaaattct taatcacggt   3689

 gccaaaattc attttctaac accatgtgtt agaaaattat aaaaaataaa ataattttag   3749

 aaaaaaaaaa                                                          3759




      <210> 52
      <211> 2218
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (595)..(2070)

      <400> 52
 taagcttgcg gccgcagcga ggggccggag atagcctagt tgaaaggccc gggcgtctcg     60

 gcggggagcg cgttccgcgc tgtagggtaa tcgcgccggg cggccggccg gctggccggg    120

 cctcagcggg agccaccggg ggctgcgggc ggccgtggga cctgcggaga cctcctcggg    180

 gcgcagggaa cacgctacag ccttcgccgc ggcgggcttg tggggagcgg cgtcccagcc    240

 tttcccggga ggctcagcca ggtgcctgga gcgggagagt cggactcaga ttcctgcttt    300

 acctagaata gcaacgtgcc ctgttcccgt tgtaccctct taaatactat acttcttaaa    360

 cggcctgtct cccgggaaat ttggatatgt gcagtgcatc tcctcgaaga tgctgatggt    420

 ggaaatttct tgaaaccgct ctcgtaattt gccacgtgct gttgcaaata ttctggtgaa    480

 tgaacacaga atcagcatgg ctttcctttg ctgagaaatc actgatggga agtgagactt    540

 gttaaacttg aaagtgaatg gacctgagtg gaccctttga tcacatcagt aaac  atg     597
                                                              Met
                                                                1

 agc ggt acc aaa cct gat att tta tgg gca cca cac cat gtt gat aga      645
 Ser Gly Thr Lys Pro Asp Ile Leu Trp Ala Pro His His Val Asp Arg
               5                  10                  15

 ttt gtt gtg tgt gac tca gaa cta agt ctt tat cat gtg gaa tct act      693
 Phe Val Val Cys Asp Ser Glu Leu Ser Leu Tyr His Val Glu Ser Thr
          20                  25                  30

 gtg aat tca gaa ctc aaa gct gga tct tta cgt tta tct gaa gac tct      741
 Val Asn Ser Glu Leu Lys Ala Gly Ser Leu Arg Leu Ser Glu Asp Ser
      35                  40                  45

 gca gct aca tta ctg tca ata aat tca gat aca ccc tat atg aaa tgt      789
 Ala Ala Thr Leu Leu Ser Ile Asn Ser Asp Thr Pro Tyr Met Lys Cys
  50                  55                  60                  65

 gtt gcc tgg tat ctt aat tat gat cct gaa tgt ctg ctg gca gtt gga      837
 Val Ala Trp Tyr Leu Asn Tyr Asp Pro Glu Cys Leu Leu Ala Val Gly
                  70                  75                  80

 caa gca aat ggt cga gtt gta ctt aca agc ctt ggt caa gat cat aac      885
 Gln Ala Asn Gly Arg Val Val Leu Thr Ser Leu Gly Gln Asp His Asn
              85                  90                  95

 tca aag ttc aaa gat ttg ata gga aaa gag ttt gtt cca aaa cat gca      933
 Ser Lys Phe Lys Asp Leu Ile Gly Lys Glu Phe Val Pro Lys His Ala
         100                 105                 110

 cga caa tgt aat acc ctt gcc tgg aat cca ctg gat agt aac tgg cta      981
 Arg Gln Cys Asn Thr Leu Ala Trp Asn Pro Leu Asp Ser Asn Trp Leu
     115                 120                 125

 gct gct ggt tta gat aag cac aga gct gac ttt tca gtg cta ata tgg     1029
 Ala Ala Gly Leu Asp Lys His Arg Ala Asp Phe Ser Val Leu Ile Trp
 130                 135                 140                 145

 gat atc tgc agc aaa tat act cct gat ata gtt ccc atg gaa aaa gtg     1077
 Asp Ile Cys Ser Lys Tyr Thr Pro Asp Ile Val Pro Met Glu Lys Val
                 150                 155                 160

 aaa ctt tca gca ggt gaa act gaa aca aca tta tta gta aca aaa cca     1125
 Lys Leu Ser Ala Gly Glu Thr Glu Thr Thr Leu Leu Val Thr Lys Pro
             165                 170                 175

 ctt tat gag tta gga cag aat gat gct tgt ctg tct ctt tgt tgg ctt     1173
 Leu Tyr Glu Leu Gly Gln Asn Asp Ala Cys Leu Ser Leu Cys Trp Leu
         180                 185                 190

 cca cga gac cag aaa ctt ctc ctt gct ggt atg cat cgt aac cta gct     1221
 Pro Arg Asp Gln Lys Leu Leu Leu Ala Gly Met His Arg Asn Leu Ala
     195                 200                 205

 ata ttt gat ctt cgg aat aca agc caa aag atg ttc gta aat aca aaa     1269
 Ile Phe Asp Leu Arg Asn Thr Ser Gln Lys Met Phe Val Asn Thr Lys
 210                 215                 220                 225

 gct gtt cag ggt gtg acg gta gac cca tat ttc cac gat cgt gtt gct     1317
 Ala Val Gln Gly Val Thr Val Asp Pro Tyr Phe His Asp Arg Val Ala
                 230                 235                 240

 tcc ttc tat gaa ggt cag gtt gca ata tgg gat ctt aga aaa ttt gag     1365
 Ser Phe Tyr Glu Gly Gln Val Ala Ile Trp Asp Leu Arg Lys Phe Glu
             245                 250                 255

 aag cca gtt ttg aca ttg act gag caa cca aaa ccc tta aca aaa gta     1413
 Lys Pro Val Leu Thr Leu Thr Glu Gln Pro Lys Pro Leu Thr Lys Val
         260                 265                 270

 gca tgg tgt ccc act agg act ggt cta ctt gcc act tta aca agg gat     1461
 Ala Trp Cys Pro Thr Arg Thr Gly Leu Leu Ala Thr Leu Thr Arg Asp
     275                 280                 285

 agt aat att att aga ttg tat gat atg cag cat aca ccc act ccc att     1509
 Ser Asn Ile Ile Arg Leu Tyr Asp Met Gln His Thr Pro Thr Pro Ile
 290                 295                 300                 305

 ggg gat gaa act gaa ccc aca ata att gaa aga agt gtg caa cct tgt     1557
 Gly Asp Glu Thr Glu Pro Thr Ile Ile Glu Arg Ser Val Gln Pro Cys
                 310                 315                 320

 gac aat tac att gct tcc ttt gcg tgg cat cca aca agt caa aat cga     1605
 Asp Asn Tyr Ile Ala Ser Phe Ala Trp His Pro Thr Ser Gln Asn Arg
             325                 330                 335

 atg ata gtt gta act ccc aac cga aca atg tca gac ttc act gtt ttt     1653
 Met Ile Val Val Thr Pro Asn Arg Thr Met Ser Asp Phe Thr Val Phe
         340                 345                 350

 gaa agg ata tct ctt gcc tgg agc cca att aca tct tta atg tgg gct     1701
 Glu Arg Ile Ser Leu Ala Trp Ser Pro Ile Thr Ser Leu Met Trp Ala
     355                 360                 365

 tgt ggt cgt cat tta tat gaa tgt acg gaa gaa gaa aat gat aat tct     1749
 Cys Gly Arg His Leu Tyr Glu Cys Thr Glu Glu Glu Asn Asp Asn Ser
 370                 375                 380                 385

 tta gaa aaa gat ata gca acg aag atg cgt ctt cgg gct tta tca agg     1797
 Leu Glu Lys Asp Ile Ala Thr Lys Met Arg Leu Arg Ala Leu Ser Arg
                 390                 395                 400

 tat gga ctt gat aca gag cag gtg tgg agg aac cac att tta gct gga     1845
 Tyr Gly Leu Asp Thr Glu Gln Val Trp Arg Asn His Ile Leu Ala Gly
             405                 410                 415

 gga acc aaa tca gat gaa aaa gtg gac ttg agc aag gac aaa aaa tta     1893
 Gly Thr Lys Ser Asp Glu Lys Val Asp Leu Ser Lys Asp Lys Lys Leu
         420                 425                 430

 gcc caa ttt aac aac tgg ttt aca tgg tgt cat aat tgc agg cac ggt     1941
 Ala Gln Phe Asn Asn Trp Phe Thr Trp Cys His Asn Cys Arg His Gly
     435                 440                 445

 gga cat gct gga cat atg ctt agt tgg ttc agg gac cat gca gag tgc     1989
 Gly His Ala Gly His Met Leu Ser Trp Phe Arg Asp His Ala Glu Cys
 450                 455                 460                 465

 cct gtg tct gca tgc acg tgt aaa tgt atg cag ttg gat aca acg ggg     2037
 Pro Val Ser Ala Cys Thr Cys Lys Cys Met Gln Leu Asp Thr Thr Gly
                 470                 475                 480

 aat ctg gta cct gca gag act gtc cag cca taa aatgttac caccttaaga     2088
 Asn Leu Val Pro Ala Glu Thr Val Gln Pro 
             485                 490

 gaacccttca agtgtggagc tttctagtag gtgtccttca tagctcagaa acatacctca   2148

 gaacaagcca ttcatgactt acctgtaatg ggaaaataca tcattctatc agatcagcaa   2208

 aaaaaaaaaa                                                          2218




      <210> 53
      <211> 1361
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (307)..(978)

      <400> 53
 tttgaaatcc atatcacttg actacgccaa gcttggcacg agggcgatgg cggagtcgct     60

 gcccctggag atgctcacat atattctgag cttcctgcct ctgtcagatc agaaagaggc    120

 ctccctcgtg agttgggctt ggtaccgtgc tgcccagaat gcccttcggg agcaaccagg    180

 ccttacctcc ctggacctca gtggctgctc agaactgact gatggggcgc tcttggccgt    240

 gagccggggc ctgcggcacc tgcggcgcct gagcctgggg aagctgcagc ggctgacaga    300

 tgcagg   atg tac agc tct ggg tgg cct gca gga gct gca gag cct cga     348
          Met Tyr Ser Ser Gly Trp Pro Ala Gly Ala Ala Glu Pro Arg
            1               5                  10

 cat ggc cga ggg cgg gaa ctg gcc cag gcc ctg ggc tgt atg cac ggg      396
 His Gly Arg Gly Arg Glu Leu Ala Gln Ala Leu Gly Cys Met His Gly
  15                  20                  25                  30

 gct cca tcc cag ctg gcc tcc ctc agc ctg gcc cac tgc tct tca ttg      444
 Ala Pro Ser Gln Leu Ala Ser Leu Ser Leu Ala His Cys Ser Ser Leu
                  35                  40                  45

 aag tca cgc cca gag ctg gag cat cag gcc tca ggt acc aag gac gcc      492
 Lys Ser Arg Pro Glu Leu Glu His Gln Ala Ser Gly Thr Lys Asp Ala
              50                  55                  60

 tgt cca gag cca cag ggc ccc tcc ctg ctc acg ctg cgg gcc ctg cag      540
 Cys Pro Glu Pro Gln Gly Pro Ser Leu Leu Thr Leu Arg Ala Leu Gln
          65                  70                  75

 gag ttg gac ctc aca gcc tgc agc aag ctg act gat gcc agt tta gcc      588
 Glu Leu Asp Leu Thr Ala Cys Ser Lys Leu Thr Asp Ala Ser Leu Ala
      80                  85                  90

 aag gtg ctc cag ttt ctc cag ctg agg cag ctg tcc ctt agc ctg ttg      636
 Lys Val Leu Gln Phe Leu Gln Leu Arg Gln Leu Ser Leu Ser Leu Leu
  95                 100                 105                 110

 cca gaa ctc aca gac aac ggc ttg gtt gct gtg gcc agg ggc tgt cct      684
 Pro Glu Leu Thr Asp Asn Gly Leu Val Ala Val Ala Arg Gly Cys Pro
                 115                 120                 125

 agc ctg gag cac ttg gcg ctg agt cac tgc agc cga ctc agt gac aag      732
 Ser Leu Glu His Leu Ala Leu Ser His Cys Ser Arg Leu Ser Asp Lys
             130                 135                 140

 ggc tgg gcc cag gca gcc agc tcc tgg cca agg ctg cag cat ctc aac      780
 Gly Trp Ala Gln Ala Ala Ser Ser Trp Pro Arg Leu Gln His Leu Asn
         145                 150                 155

 ctg tcc agc tgc agt cag ctc ata gag cag aca ctg gat gct att ggg      828
 Leu Ser Ser Cys Ser Gln Leu Ile Glu Gln Thr Leu Asp Ala Ile Gly
     160                 165                 170

 cag gcg tgc agg cag ctc cgg gtg ttg gat gtg gcc acg tgc cct ggc      876
 Gln Ala Cys Arg Gln Leu Arg Val Leu Asp Val Ala Thr Cys Pro Gly
 175                 180                 185                 190

 atc aac atg gcc gcc gtc aga cgc ttc caa gcc cag ctg ccc cag gtg      924
 Ile Asn Met Ala Ala Val Arg Arg Phe Gln Ala Gln Leu Pro Gln Val
                 195                 200                 205

 tcc tgt gtc cag tcc cgc ttc gtg gga ggg gct gac ctg acc cta aca      972
 Ser Cys Val Gln Ser Arg Phe Val Gly Gly Ala Asp Leu Thr Leu Thr
             210                 215                 220

 ctc tga ggccagaccc tctaggactg ggggtggggc caatccaggg cagcccagag      1028
 Leu 


 ggaacatcct gccacaccgc ctggcagtag cctctttcca gctacacgtc gctgccacag   1088

 gcccctggaa atgctaccta cgtgttgccg ccacaggctc ctgctctctg gccaagccct   1148

 gggtgggagg ccaggccccc agcgggcagg gtctggtgct gggaggagca gagcctctgc   1208

 ctcttgcctg ccctcctctc agacctaagg ccgggctcca cctactcctg tgggactctc   1268

 ccagcaccct gtgtgcactg agcttcagca gctgagccta ggtctgtgct gtaaatccta   1328

 agattaaaca ttccagatag taaaaaaaaa aaa                                1361




      <210> 54
      <211> 742
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (115)..(570)

      <400> 54
 ggcccattta gtgacacata gaacaagttg gacaaaaaag caggtgggta cggtccggat     60

 tcccgggtcg acccacgcgt ccgggaaaag gtcccggaga gctgagcagt caag  atg     117
                                                              Met
                                                                1

 tgt gac ttc acc gaa gac cag acc gca gag ttc aag gag gcc ttc cag      165
 Cys Asp Phe Thr Glu Asp Gln Thr Ala Glu Phe Lys Glu Ala Phe Gln
               5                  10                  15

 ctg ttt gac cga aca ggt gat ggc aag atc ctg tac agc cag tgt ggg      213
 Leu Phe Asp Arg Thr Gly Asp Gly Lys Ile Leu Tyr Ser Gln Cys Gly
          20                  25                  30

 gat gtg atg agg gcc ctg ggc cag aac cct acc aac gcc gag gtg ctc      261
 Asp Val Met Arg Ala Leu Gly Gln Asn Pro Thr Asn Ala Glu Val Leu
      35                  40                  45

 aag gtc ctg ggg aac ccc aag agt gat gag atg aat gtg aag gtg ctg      309
 Lys Val Leu Gly Asn Pro Lys Ser Asp Glu Met Asn Val Lys Val Leu
  50                  55                  60                  65

 gac ttt gag cac ttt ctg ccc atg ctg cag aca gtg gcc aag aac aag      357
 Asp Phe Glu His Phe Leu Pro Met Leu Gln Thr Val Ala Lys Asn Lys
                  70                  75                  80

 gac cag ggc acc tat gag gat tat gtc gaa gga ctt cgg gtg ttt gac      405
 Asp Gln Gly Thr Tyr Glu Asp Tyr Val Glu Gly Leu Arg Val Phe Asp
              85                  90                  95

 aag gaa gga aat ggc acc gtc atg ggt gct gaa atc cgg cat gtt ctt      453
 Lys Glu Gly Asn Gly Thr Val Met Gly Ala Glu Ile Arg His Val Leu
         100                 105                 110

 gtc aca ctg ggt gag aag atg aca gag gaa gaa gta gag atg ctg gtg      501
 Val Thr Leu Gly Glu Lys Met Thr Glu Glu Glu Val Glu Met Leu Val
     115                 120                 125

 gca ggg cat gag gac agc aat ggt tgt atc aac tat gaa gag ctc gtc      549
 Ala Gly His Glu Asp Ser Asn Gly Cys Ile Asn Tyr Glu Glu Leu Val
 130                 135                 140                 145

 cgc atg gtg ctg aat ggc tga gg accttcccag tctccccaga gtccgtgcct      602
 Arg Met Val Leu Asn Gly 
                 150

 ttccctgtgt gaattttgta tctagcctaa agtttcccta ggctttcttg tctcagcaac    662

 tttcccatct tgtctctctt ggatgatgtt tgccgtcagc attcaccaaa taaacttgct    722

 ctctgggcaa aaaaaaaaaa                                                742




      <210> 55
      <211> 2148
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1156)..(1839)

      <400> 55
 gcagtgaaaa tgttattagt tttgaggggg tttgggaagc ccagcggtac ctgaggagtt     60

 tctggacatt taagccggct cctaggtgtg gccttaacag ggaggctgcc cttcctttca    120

 ctgaatgagc tgcgtcactc ataagctcac tgagggaacc ccatctgcca gctcgtgcgt    180

 gctcagacga cgtccatgtc tcaagcgttc tgtgaaggct gcggtgcagc gtgaggtcac    240

 cctgctgtgt tcagagcttt gctcactgcc tgcggggctg gaccgttgca cctccagggc    300

 ccccagaaac cgagtttcgg gtcagggtcc tctgtgtgca ttcctggggg tccatgtacc    360

 agctgtgacg acgtccaggg gttgggctga gaagcagaca cccttgggga aactggctct    420

 gtccctcccc tcccccatcc caggagctga ggtcttggtg aggccacagg gccaggtcca    480

 cgcaaggact gtccgtgtcc tgtcctgtgg tctctggccc cacgtgacac ccacacgtgt    540

 ggtaggcagc ctggcctggg ttgtggctat ggccaggccc ccaagctgtc cccgatgccc    600

 agggctggtg accacccagg caggtggggg ccccacttgg taacagagtc atagggcaga    660

 acccacctgg gctgccacag aaggtctggc tgcccctgtg cccactgctc cccaccatgg    720

 ccaatcagaa gagtcagggg ctcctggtct ttccgggagg gacgtggccc agccagctct    780

 aggtgttctg agcagctctg ggacccagcg attgaggggt caggctgggg gtgtcagagc    840

 cagggtcctc cttaagtacc tcccacacta cacagacagt ggcccttttg tgggcagcaa    900

 attcttgagc catgaaagga tgctttgggc cccttccctc ccaggagggc agcctgtgca    960

 gggatggtgc tcagcaggtg gacagggcct ggggcctgtg tcagggtctc aggcctggga   1020

 gcaccagcag aggagatggc ggctcccagc agtgccgcct gaaagtgtct tgggctaagg   1080

 acccacaccc agggctgccc tgcagaaacg cccccgcaga gcccagtggt ctgtgaggtt   1140

 gcaggcaggg tgcga atg gaa ggg cac agg tgc ggg gct ggc acc tgc ccg    1191
                  Met Glu Gly His Arg Cys Gly Ala Gly Thr Cys Pro
                    1               5                  10

 gtc ctg ccc acc tcc cct ccg ccc agc ccg cac ctg cgt ctc ccc aca     1239
 Val Leu Pro Thr Ser Pro Pro Pro Ser Pro His Leu Arg Leu Pro Thr
          15                  20                  25

 gag ctg tcc gtg gca cag tgc acg cag cgg ccc gtg gac atc gtc ttc     1287
 Glu Leu Ser Val Ala Gln Cys Thr Gln Arg Pro Val Asp Ile Val Phe
      30                  35                  40

 ctg ctg gac ggc tcc gag cgg ctg ggt gag cag aac ttc cac aag gcc     1335
 Leu Leu Asp Gly Ser Glu Arg Leu Gly Glu Gln Asn Phe His Lys Ala
  45                  50                  55                  60

 cgg cgc ttc gtg gag cag gtg gcg cgg cgg ctg acg ctg gcc cgg agg     1383
 Arg Arg Phe Val Glu Gln Val Ala Arg Arg Leu Thr Leu Ala Arg Arg
                  65                  70                  75

 gac gac gac cct ctc aac gca cgc gtg gcg ctg ctg cag ttt ggt ggc     1431
 Asp Asp Asp Pro Leu Asn Ala Arg Val Ala Leu Leu Gln Phe Gly Gly
              80                  85                  90

 ccc ggc gag cag cag gtg gcc ttc ccg ctg agc cac aac ctc acg gcc     1479
 Pro Gly Glu Gln Gln Val Ala Phe Pro Leu Ser His Asn Leu Thr Ala
          95                 100                 105

 atc cac gag gcg ctg gag acc aca caa tac ctg aac tcc ttc tcg cac     1527
 Ile His Glu Ala Leu Glu Thr Thr Gln Tyr Leu Asn Ser Phe Ser His
     110                 115                 120

 gtg ggc gca ggc gtg gtg cac gcc atc aat gcc atc gtg cgc agc ccg     1575
 Val Gly Ala Gly Val Val His Ala Ile Asn Ala Ile Val Arg Ser Pro
 125                 130                 135                 140

 cgt ggc ggg gcc cgg agg cac gca gag ctg tcc ttc gtg ttc ctc acg     1623
 Arg Gly Gly Ala Arg Arg His Ala Glu Leu Ser Phe Val Phe Leu Thr
                 145                 150                 155

 gac ggc gtc acg ggc aac gac agt ctg cac gag tcg gcg cac tcc atg     1671
 Asp Gly Val Thr Gly Asn Asp Ser Leu His Glu Ser Ala His Ser Met
             160                 165                 170

 cgc aag cag aac gtg gta ccc acc gtg ctg gcc ttg ggc agc gac gtg     1719
 Arg Lys Gln Asn Val Val Pro Thr Val Leu Ala Leu Gly Ser Asp Val
         175                 180                 185

 gac atg gac gtg ctc acc acg ctc agc ctg ggt gac cgc gcc gcc gtg     1767
 Asp Met Asp Val Leu Thr Thr Leu Ser Leu Gly Asp Arg Ala Ala Val
     190                 195                 200

 ttc cac gag aag gac tat gac agc ctg gcg caa ccc ggc ttc ttc gac     1815
 Phe His Glu Lys Asp Tyr Asp Ser Leu Ala Gln Pro Gly Phe Phe Asp
 205                 210                 215                 220

 cgc ttc atc cgc tgg atc tgc tag cgccgccgcc cgggccccgc agtcgagggt    1869
 Arg Phe Ile Arg Trp Ile Cys 
                 225

 cgtgagccca ccccgtccat ggtgctaagc gggcccgggt cccacacggc cagcaccgct   1929

 gctcactcgg acgacgccct gggcctgcac ctctccagct cctcccacgg ggtccccgta   1989

 gccccggccc ccgcccagcc ccaggtctcc ccaggccctc cgcaggctgc ccggcctccc   2049

 tccccctgca gccatcccaa ggctcctgac ctacctggcc cctgagctct ggagcaagcc   2109

 ctgacccaat aaaggctttg aacccataaa aaaaaaaaa                          2148




      <210> 56
      <211> 669
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (72)..(626)

      <400> 56
 aaggatcctt aattaaatta atcccccccc cccccgctct ttccctaagc agcctgaggt     60

 gatctgtgaa a atg gtt cgc tat tca ctt gac ccg gag aac ccc acg aaa     110
              Met Val Arg Tyr Ser Leu Asp Pro Glu Asn Pro Thr Lys
                1               5                  10

 tca tgc aaa tca aga ggt tcc aat ctt cgt gtt cac ttt aag aac act      158
 Ser Cys Lys Ser Arg Gly Ser Asn Leu Arg Val His Phe Lys Asn Thr
      15                  20                  25

 cgt gaa act gct cag gcc atc aag ggt atg cat ata cga aaa gcc acg      206
 Arg Glu Thr Ala Gln Ala Ile Lys Gly Met His Ile Arg Lys Ala Thr
  30                  35                  40                  45

 aag tat ctg aaa gat gtc act tta cag aaa cag tgt gta cca ttc cga      254
 Lys Tyr Leu Lys Asp Val Thr Leu Gln Lys Gln Cys Val Pro Phe Arg
                  50                  55                  60

 cgt tac aat ggt gga gtt ggc agg tgt gcg cag gcc aag caa tgg ggc      302
 Arg Tyr Asn Gly Gly Val Gly Arg Cys Ala Gln Ala Lys Gln Trp Gly
              65                  70                  75

 tgg aca caa ggt cgg tgg ccc aaa aag agt gct gaa ttt ttg ctg cac      350
 Trp Thr Gln Gly Arg Trp Pro Lys Lys Ser Ala Glu Phe Leu Leu His
          80                  85                  90

 atg ctt aaa aac gca gag agt aat gct gaa ctt aag ggt tta gat gta      398
 Met Leu Lys Asn Ala Glu Ser Asn Ala Glu Leu Lys Gly Leu Asp Val
      95                 100                 105

 gat tct ctg gtc att gag cat atc caa gtg aac aaa gca cct aag atg      446
 Asp Ser Leu Val Ile Glu His Ile Gln Val Asn Lys Ala Pro Lys Met
 110                 115                 120                 125

 cgc cgc cgg acc tac aga gct cat ggt cgg att aac cca tac atg agc      494
 Arg Arg Arg Thr Tyr Arg Ala His Gly Arg Ile Asn Pro Tyr Met Ser
                 130                 135                 140

 tct ccc tgc cac att gag atg atc ctt acg gaa aag gaa cag att gtt      542
 Ser Pro Cys His Ile Glu Met Ile Leu Thr Glu Lys Glu Gln Ile Val
             145                 150                 155

 cct aaa cca gaa gag gag gtt gcc cag aag aaa aag ata tcc cag aag      590
 Pro Lys Pro Glu Glu Glu Val Ala Gln Lys Lys Lys Ile Ser Gln Lys
         160                 165                 170

 aaa ctg aag aaa caa aaa ctt atg gca cgg gag taa attc agcattaaaa      640
 Lys Leu Lys Lys Gln Lys Leu Met Ala Arg Glu 
     175                 180

 taaatgtaat taaaaggaaa aaaaaaaaa                                      669




      <210> 57
      <211> 2269
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (487)..(1617)

      <400> 57
 atggggcctg gccaggctat tcgcctggaa gctcggcgaa ttctcaggat ggcggctggg     60

 gctccaggcg gctgcggcag ctctggagct aaatattaca tttccactcc tggatttaag    120

 atagggctgc ttactgactg gctagaagag gcaaaagaag gcacagtaaa gggaaatatt    180

 ttcatcttca gatttaagga ttcctcgaga aaggaatcaa attcagaaaa tgcagacctc    240

 agacctgcat ccccatcatc acccccttca gagctagaag cgaggaactg ctttcgtctg    300

 gggatcagga gcatcggatt gctgtttccc acaacagaac ccggaagcaa acatccccgg    360

 tgcccaagga tcaggaaggt gtgggaggca gttcaggctg ccagggagca ctcgctgtat    420

 ctaaaccaac cagcccccaa ccagagcgac aaggacaaga agaagggggg ctccaaggag    480

 aaggcc   atg aat tac gaa ttt gag cga gag att ggt ttt atc aat agc     528
          Met Asn Tyr Glu Phe Glu Arg Glu Ile Gly Phe Ile Asn Ser
            1               5                  10

 cag ccg tcg ctc gct gag tgc ctg aca tct ttt ccc cct gtc gct gat      576
 Gln Pro Ser Leu Ala Glu Cys Leu Thr Ser Phe Pro Pro Val Ala Asp
  15                  20                  25                  30

 aca ttt caa agt tca tca atc aag acc tcg acg ctt tca cac tcg aca      624
 Thr Phe Gln Ser Ser Ser Ile Lys Thr Ser Thr Leu Ser His Ser Thr
                  35                  40                  45

 cta att cct cct cct ttt gag cag acc att ccc agc ctg aac ccc ggc      672
 Leu Ile Pro Pro Pro Phe Glu Gln Thr Ile Pro Ser Leu Asn Pro Gly
              50                  55                  60

 agt cac cct cgc cac ggc gct ggc ggc cgc ccc aag ccg agc ccc gcg      720
 Ser His Pro Arg His Gly Ala Gly Gly Arg Pro Lys Pro Ser Pro Ala
          65                  70                  75

 ggc agc cgc ggc agc ccg gtg ccc gcc ggc gcc ctg cag ccg ccc gag      768
 Gly Ser Arg Gly Ser Pro Val Pro Ala Gly Ala Leu Gln Pro Pro Glu
      80                  85                  90

 tac ccc tgg atg aag gag aag aag gcg gcc aag aaa acc gca ctt ctg      816
 Tyr Pro Trp Met Lys Glu Lys Lys Ala Ala Lys Lys Thr Ala Leu Leu
  95                 100                 105                 110

 ccg gcc gcc gcc gcc gcc gcc acc gcc gca gcc acc ggc cct gct tgc      864
 Pro Ala Ala Ala Ala Ala Ala Thr Ala Ala Ala Thr Gly Pro Ala Cys
                 115                 120                 125

 ctc agc cac aaa gaa tcc ctg gaa atc gcc gat ggc agc ggc ggg gga      912
 Leu Ser His Lys Glu Ser Leu Glu Ile Ala Asp Gly Ser Gly Gly Gly
             130                 135                 140

 tcg cgg cgc ctg aga act gct tac acc aac aca cag ctt cta gag ctg      960
 Ser Arg Arg Leu Arg Thr Ala Tyr Thr Asn Thr Gln Leu Leu Glu Leu
         145                 150                 155

 gaa aaa gaa ttt cat ttc aac aag tac ctt tgc aga ccc cga agg gtg     1008
 Glu Lys Glu Phe His Phe Asn Lys Tyr Leu Cys Arg Pro Arg Arg Val
     160                 165                 170

 gag att gca gcg ctg ctg gat ttg act gag aga caa gtg aaa gtg tgg     1056
 Glu Ile Ala Ala Leu Leu Asp Leu Thr Glu Arg Gln Val Lys Val Trp
 175                 180                 185                 190

 ttt cag aac cgg agg atg aag cac aag agg cag acc cag tgc aag gaa     1104
 Phe Gln Asn Arg Arg Met Lys His Lys Arg Gln Thr Gln Cys Lys Glu
                 195                 200                 205

 aac caa aac agc gaa ggg aaa tgt aaa agc ctt gag gac tcc gag aaa     1152
 Asn Gln Asn Ser Glu Gly Lys Cys Lys Ser Leu Glu Asp Ser Glu Lys
             210                 215                 220

 gta gag gag gac gag gaa gag aag acg ctc ttt gag caa gcc ctt agc     1200
 Val Glu Glu Asp Glu Glu Glu Lys Thr Leu Phe Glu Gln Ala Leu Ser
         225                 230                 235

 gtc tct ggg gcc ctt ctg gag agg gaa ggc tac act ttt cag caa aat     1248
 Val Ser Gly Ala Leu Leu Glu Arg Glu Gly Tyr Thr Phe Gln Gln Asn
     240                 245                 250

 gcc ctc tct cag cag cag gct ccc aat gga cac aat ggc gac tcc caa     1296
 Ala Leu Ser Gln Gln Gln Ala Pro Asn Gly His Asn Gly Asp Ser Gln
 255                 260                 265                 270

 agt ttc cca gtc tcg cct tta acc agc aat gag aaa aat ctg aaa cat     1344
 Ser Phe Pro Val Ser Pro Leu Thr Ser Asn Glu Lys Asn Leu Lys His
                 275                 280                 285

 ttt cag cac cag tca ccc act gtt ccc aac tgc ttg tca aca atg ggc     1392
 Phe Gln His Gln Ser Pro Thr Val Pro Asn Cys Leu Ser Thr Met Gly
             290                 295                 300

 cag aac tgt gga gct ggc cta aac aat gac agt cct gag gcc ctt gag     1440
 Gln Asn Cys Gly Ala Gly Leu Asn Asn Asp Ser Pro Glu Ala Leu Glu
         305                 310                 315

 gtc ccc tct ttg cag gac ttt agc gtt ttc tcc aca gat tcc tgc ctg     1488
 Val Pro Ser Leu Gln Asp Phe Ser Val Phe Ser Thr Asp Ser Cys Leu
     320                 325                 330

 cag ctt tca gat gca gtt tca ccc agt ttg cca ggt tcc ctc gac agt     1536
 Gln Leu Ser Asp Ala Val Ser Pro Ser Leu Pro Gly Ser Leu Asp Ser
 335                 340                 345                 350

 ccc gta gat att tca gct gac agc tta gac ttt ttt aca gac aca ctc     1584
 Pro Val Asp Ile Ser Ala Asp Ser Leu Asp Phe Phe Thr Asp Thr Leu
                 355                 360                 365

 acc aca atc gac ttg cag cat ctg aat tac taa aaacatta aagcaaaaca     1635
 Thr Thr Ile Asp Leu Gln His Leu Asn Tyr 
             370                 375

 aagcatcacc aaacaaaaac tcctttgacc aggtggtttt gccttctttt atttgggagt   1695

 ttatttttta ttttcttctt gacctacccc ttccctcctt taagtgttga ggattttctg   1755

 tttagtgatt ccctgaccca gtttcaaaca gagccatctt ttacagatta ttttggagtt   1815

 ttagttgttt taaacctaac tcaacaaccc tttatgtgat tcctgagagc agtatgaggc   1875

 ctgcaagaaa gtgatcatat aattgtatct tcactttctt tttatttttg tattacattg   1935

 ggatgcattg tcatgcatat tttttgtaga ataaattctc ctttgctata agtagcttat   1995

 ttttctcccc ctcttttttc aaggctcata acgggttctt tttcttcttt tagtctaact   2055

 tcgtaaataa aattcgtcac aatttatctt cttttttcaa ttttaataca tttattaagg   2115

 cggcatgttc aaagtcttca atggacagca acaaaacaga aagccaaaaa atgactaggg   2175

 cttctaataa gtgttttttc tttctttttc gcttcttctt ctcctctttc tttttaaagg   2235

 atttgagagg agaagaagaa ccaaaaaaaa aaaa                               2269




      <210> 58
      <211> 731
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (142)..(585)

      <400> 58
 gcaaggtggg gccccaccgg gccatgtctt ccacagacac atatgtgtgc aaaatgatgc     60

 agcagaacag ggggactcct gcagtgctgc ttagaactac tcaaatccag caacacactc    120

 ttacaccaga gatggaataa g  atg gca cct tat acc aga gat gga aac tgc     171
                          Met Ala Pro Tyr Thr Arg Asp Gly Asn Cys
                            1               5                  10

 ccc agc tat gtc aaa aga agg tgg ggg aaa aga gca aca ctt gca aaa      219
 Pro Ser Tyr Val Lys Arg Arg Trp Gly Lys Arg Ala Thr Leu Ala Lys
                  15                  20                  25

 ctg ttg aca tgt gca tct gct tgt ttc tgt gga gag tat ctg cag cat      267
 Leu Leu Thr Cys Ala Ser Ala Cys Phe Cys Gly Glu Tyr Leu Gln His
              30                  35                  40

 acc agg gga cag aaa act cag gct gcc tcc agg gag ggg aag tgg gtg      315
 Thr Arg Gly Gln Lys Thr Gln Ala Ala Ser Arg Glu Gly Lys Trp Val
          45                  50                  55

 ctg gag ccc aga gtg agc ata cag ttt ctg gac gtg gat tcc act gca      363
 Leu Glu Pro Arg Val Ser Ile Gln Phe Leu Asp Val Asp Ser Thr Ala
      60                  65                  70

 tct ttt gtc tat tct gga gac agg gtc tca ctc tgt cac cca ggc tgg      411
 Ser Phe Val Tyr Ser Gly Asp Arg Val Ser Leu Cys His Pro Gly Trp
  75                  80                  85                  90

 agt aaa gtg att caa tca cag ctc agg aag cat cga act ctg ggg ctc      459
 Ser Lys Val Ile Gln Ser Gln Leu Arg Lys His Arg Thr Leu Gly Leu
                  95                 100                 105

 aag caa tcc tcc tgt ctc agc ctc cca aac agc tgg gac tac aag cat      507
 Lys Gln Ser Ser Cys Leu Ser Leu Pro Asn Ser Trp Asp Tyr Lys His
             110                 115                 120

 gaa tca cta tgc ctg gcc aac cta ctc tat ctt ttg agt ttc ata ctt      555
 Glu Ser Leu Cys Leu Ala Asn Leu Leu Tyr Leu Leu Ser Phe Ile Leu
         125                 130                 135

 cat ccc tgg ata acc cgg tca ata aaa taa a atagtgagtg ggttccccaa      606
 His Pro Trp Ile Thr Arg Ser Ile Lys 
     140                 145

 ggaccggcca gaccgggaag aaaagtttaa taagaacaga acgctagggg agcctgaagg    666

 agctcaagca ttttctggaa taccccacag agtaaccctg ccagcctgaa agcaaccgag    726

 actta                                                                731




      <210> 59
      <211> 515
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (191)..(457)

      <400> 59
 cgcgagggtc gcgaagggca caacacttgg cctctcgctg gccctgctcg cggatcccga     60

 gtagagaacg caagcaccca cgcccgcctg caagctcccg ggcgcccccg gcctctcctg    120

 ctcggcggaa cgaggataac ccagtagagc cggacccagg gatattattg ataataaggc    180

 ctctgtaacc   atg gct agt tct gac gta aaa cca aca tca gta agt cat     229
              Met Ala Ser Ser Asp Val Lys Pro Thr Ser Val Ser His
                1               5                  10

 gcc aaa aaa tgg tca gaa gag ata gaa aat ctg tac aga ttt caa caa      277
 Ala Lys Lys Trp Ser Glu Glu Ile Glu Asn Leu Tyr Arg Phe Gln Gln
      15                  20                  25

 gca gga tat cgg gat gaa acc gaa tat aga caa gtg aaa caa gtt tct      325
 Ala Gly Tyr Arg Asp Glu Thr Glu Tyr Arg Gln Val Lys Gln Val Ser
  30                  35                  40                  45

 atg gta gat cgt tgg ccg gag aca gga tat gtg aag aaa ctt cag aga      373
 Met Val Asp Arg Trp Pro Glu Thr Gly Tyr Val Lys Lys Leu Gln Arg
                  50                  55                  60

 agg gac aat acg ttc tat tac tac aac aaa cag agg gaa tgt gat gac      421
 Arg Asp Asn Thr Phe Tyr Tyr Tyr Asn Lys Gln Arg Glu Cys Asp Asp
              65                  70                  75

 aaa gaa gtc cac aaa gtg aaa att tat gct tac tag cctg tcttctttgt      471
 Lys Glu Val His Lys Val Lys Ile Tyr Ala Tyr 
          80                  85

 attacttgtc aattatattt taagtattca tcaaaaaaaa aaaa                     515




      <210> 60
      <211> 983
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (90)..(803)

      <400> 60
 tttcgtcgca cgtggaacct ctcctggtcc tgttgacccg ggcccctcgg aacctccagc     60

 ttggtccggt ctgggactgg aagcctgcc  atg gcg gct tct gcg gcg gag acg     113
                                  Met Ala Ala Ser Ala Ala Glu Thr
                                    1               5

 cgc gtg ttt ctg gag gtg cgg gga cag ctg cag agc gcg ctt ctg atc      161
 Arg Val Phe Leu Glu Val Arg Gly Gln Leu Gln Ser Ala Leu Leu Ile
      10                  15                  20

 ctg gga gaa ccg aaa gaa gga ggt atg ccc atg aat att tcc ata atg      209
 Leu Gly Glu Pro Lys Glu Gly Gly Met Pro Met Asn Ile Ser Ile Met
  25                  30                  35                  40

 cca tct tca ctc cag atg aaa acc cct gaa ggc tgc aca gaa atc cag      257
 Pro Ser Ser Leu Gln Met Lys Thr Pro Glu Gly Cys Thr Glu Ile Gln
                  45                  50                  55

 ctt cca gca gag gtc agg ctt gta cct tcc tct tgc cgt ggg cta cag      305
 Leu Pro Ala Glu Val Arg Leu Val Pro Ser Ser Cys Arg Gly Leu Gln
              60                  65                  70

 ttt gtt gtt gga gat gga ctg cac ctg cga ctg cag acg caa gca aaa      353
 Phe Val Val Gly Asp Gly Leu His Leu Arg Leu Gln Thr Gln Ala Lys
          75                  80                  85

 tta ggc aca aaa ctg att tca atg ttt aat caa agc tcg caa acc caa      401
 Leu Gly Thr Lys Leu Ile Ser Met Phe Asn Gln Ser Ser Gln Thr Gln
      90                  95                 100

 gaa tgt tgc acg ttt tat tgc caa tcc tgc ggt gaa gtc ata ata aaa      449
 Glu Cys Cys Thr Phe Tyr Cys Gln Ser Cys Gly Glu Val Ile Ile Lys
 105                 110                 115                 120

 gac agg aag ctc ctc agg gtg ctc cca ctg ccg agt gag aac tgg gga      497
 Asp Arg Lys Leu Leu Arg Val Leu Pro Leu Pro Ser Glu Asn Trp Gly
                 125                 130                 135

 gct cta gtt gga gaa tgg tgt tgt cat cct gac ccc ttt gct aat aaa      545
 Ala Leu Val Gly Glu Trp Cys Cys His Pro Asp Pro Phe Ala Asn Lys
             140                 145                 150

 tca ctt cat ccg caa gag aat gac tgt ttt att gga gac tct ttc ttc      593
 Ser Leu His Pro Gln Glu Asn Asp Cys Phe Ile Gly Asp Ser Phe Phe
         155                 160                 165

 ttg gtg aat tta aga acc agt ttg tgg cag caa aga cct gaa cta tcc      641
 Leu Val Asn Leu Arg Thr Ser Leu Trp Gln Gln Arg Pro Glu Leu Ser
     170                 175                 180

 cca gtg gag atg tgc tgt gtt tct tct gac aac cat tgt aaa ttg gaa      689
 Pro Val Glu Met Cys Cys Val Ser Ser Asp Asn His Cys Lys Leu Glu
 185                 190                 195                 200

 cca aag gca aat acc aaa gta att tgt aag cgt tgc aag gta atg ttg      737
 Pro Lys Ala Asn Thr Lys Val Ile Cys Lys Arg Cys Lys Val Met Leu
                 205                 210                 215

 gga gag acc gtg tca tca ggt aag aat ttc ata aca aga agc caa aat      785
 Gly Glu Thr Val Ser Ser Gly Lys Asn Phe Ile Thr Arg Ser Gln Asn
             220                 225                 230

 gat tgg ctt ctt gct taa aagcca gaatgatatt ttatagtaaa tatataggaa      839
 Asp Trp Leu Leu Ala 
         235

 agatagatga ttaatatatg ttgtggaatt ggtgcttttc aaaatagacc ccaagtaaca    899

 taccatccaa tataccaaga agtttgtata ttttgacctt cataaaaaca gaccattgaa    959

 ttttaagtaa aaagaaaaaa aaaa                                           983




      <210> 61
      <211> 1267
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (726)..(1229)

      <400> 61
 cccctcgtgc cctctctcag gatgcaaact gatcccctac gaagacaagg ctacccactt     60

 cgcgtcagtc tgcagtccct gcgcgcatgc gctttgctca ggttgccccc gccatatgct    120

 aatcactgcg ctctggagta aggcccctcc ggggaatatg caaatcactc cttccagtgc    180

 gggaggcctt tcattgtccc gcgctaggat tatgcaaata agcaggcctc gggcccagga    240

 tccagtccga actagcgccc tccaccccca gcgcatccca gttttgtaag gcgcgttcct    300

 gccccgcaca cgcacgcgcg aacccttcag cttcttgttc ctttgggccg cgggctgtac    360

 caagtaaacc caggcagcga ggggcaaagc acggcgcccc ccgcgcgggt ctcgtcgacg    420

 gcccgacgcg catagcccct cttcccacag cgctacagga ctagtccgtc tcgccgcgca    480

 agcgccctag gctcttcacg ccccctgcgc gctgtcctac cctacttgcg acgcaggcgc    540

 agaggctggg cgtgcagccg ccgccgcaga gccggagcgg gggccgccgg cgccgcatcc    600

 ctctctacct gccaacatcc tgtattagag aacttgtggc cggaggtgtg gctgtggaga    660

 gctggccggg gagggacgct gctcagctgc tgctctgctc ctgtctcctg tcccctcccc    720

 cggtc    atg aca gag acc cgt gag cca gct gag act ggg ggc tac gcc     767
          Met Thr Glu Thr Arg Glu Pro Ala Glu Thr Gly Gly Tyr Ala
            1               5                  10

 agc ttg gaa gaa gat gat gaa gac ctt tcc cca ggc ccc gag cat tcc      815
 Ser Leu Glu Glu Asp Asp Glu Asp Leu Ser Pro Gly Pro Glu His Ser
  15                  20                  25                  30

 tct gat tca gaa tac act ctc tca gag ccg gac tcc gaa gag gaa gaa      863
 Ser Asp Ser Glu Tyr Thr Leu Ser Glu Pro Asp Ser Glu Glu Glu Glu
                  35                  40                  45

 gat gag gag gag gag gaa gag gag acc act gac gat cct gaa tat gat      911
 Asp Glu Glu Glu Glu Glu Glu Glu Thr Thr Asp Asp Pro Glu Tyr Asp
              50                  55                  60

 cct ggc tac aag gtg aag cag cgc ctt ggc ggg ggc cgt ggt ggc cca      959
 Pro Gly Tyr Lys Val Lys Gln Arg Leu Gly Gly Gly Arg Gly Gly Pro
          65                  70                  75

 tcc cgc cgg gcc ccc cgt gca gcc cag ccc ccg gcc cag cct tgc cag     1007
 Ser Arg Arg Ala Pro Arg Ala Ala Gln Pro Pro Ala Gln Pro Cys Gln
      80                  85                  90

 ctc tgt ggc cgc tca ccc ctt ggg gag gcc cca ccg gga acc cca cgc     1055
 Leu Cys Gly Arg Ser Pro Leu Gly Glu Ala Pro Pro Gly Thr Pro Arg
  95                 100                 105                 110

 tgc acg ggc act tca tgc tgc atg ccc ggg gtg agg tgt agg cag agc     1103
 Cys Thr Gly Thr Ser Cys Cys Met Pro Gly Val Arg Cys Arg Gln Ser
                 115                 120                 125

 ccc cat acg ggg agc ttg gca gaa ggg gtg ggg tgg gag gag ggg gct     1151
 Pro His Thr Gly Ser Leu Ala Glu Gly Val Gly Trp Glu Glu Gly Ala
             130                 135                 140

 gag gaa att ggg gtt gtg aca gtg gtc atg ggg gat ggg gta ctg ccg     1199
 Glu Glu Ile Gly Val Val Thr Val Val Met Gly Asp Gly Val Leu Pro
         145                 150                 155

 gtc tgt gtt gtc tta gaa gta gat gtg tga t ggccagaata aaagccaaaa     1250
 Val Cys Val Val Leu Glu Val Asp Val 
     160                 165

 tctgtaaaaa aaaaaaa                                                  1267




      <210> 62
      <211> 3500
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (524)..(2869)

      <400> 62
 atgggttatg ctttcatgga caaagagcag gttctcacag catcgccccc tacagcatta     60

 gaggagccct ggggagggag ccctgcagat gctccagaag gggaacctgc agatgctcca    120

 gaaggggaac ctgcagatgc tccagaatgg gaacctgcag atgcttcaga aggggaacct    180

 gcagttgctc cagaagggga acctgcagat gctccagaag gggaacctga agatgcttca    240

 gaaggggaac ctacagatgc tccagaaggg gaagccaggg gcaggggcag aggcagggac    300

 ggggcaggaa caagggaagg tggcggcggg cggaggcgag gccgaagcgc cggggcccgc    360

 gggcagaggc cgcaaacgta tccacgcccc tcgtgcatcc tggagcgggg ctgatgacga    420

 acacagggcg cgacggacgc acacaccgcc cagcgctcgc acgacgggcc cctttcctgg    480

 gcgtctactg gcggggcccc cgccccggtt cccgggcggc acg  atg acc gac acc     535
                                                  Met Thr Asp Thr
                                                    1

 cgg cgg cgg gtg aag gtg tac acg ctc aac gag gac cgg cag tgg gac      583
 Arg Arg Arg Val Lys Val Tyr Thr Leu Asn Glu Asp Arg Gln Trp Asp
   5                  10                  15                  20

 gac cgg ggc acc ggg cat gtg tcg tct ggc tac gtg gag cgg ctg aag      631
 Asp Arg Gly Thr Gly His Val Ser Ser Gly Tyr Val Glu Arg Leu Lys
                  25                  30                  35

 ggc atg tcc ctg ctt gtc agg gct gag agc gac ggt tct cta ctt tta      679
 Gly Met Ser Leu Leu Val Arg Ala Glu Ser Asp Gly Ser Leu Leu Leu
              40                  45                  50

 gag tcg aaa ata aat cct aac act gca tac cag aaa caa cag gac act      727
 Glu Ser Lys Ile Asn Pro Asn Thr Ala Tyr Gln Lys Gln Gln Asp Thr
          55                  60                  65

 ctg att gtg tgg tct gaa gca gaa aat tat gac ttg gcc ctt agc ttt      775
 Leu Ile Val Trp Ser Glu Ala Glu Asn Tyr Asp Leu Ala Leu Ser Phe
      70                  75                  80

 caa gaa aaa gct gga tgt gat gaa att tgg gag aaa ata tgt cag gtt      823
 Gln Glu Lys Ala Gly Cys Asp Glu Ile Trp Glu Lys Ile Cys Gln Val
  85                  90                  95                 100

 caa gga aag gac cct tcc gtg gac atc act cag gac ctt gtg gat gaa      871
 Gln Gly Lys Asp Pro Ser Val Asp Ile Thr Gln Asp Leu Val Asp Glu
                 105                 110                 115

 tct gaa gag gag cgt ttt gat gat atg tca tcg cca ggc tta gaa ttg      919
 Ser Glu Glu Glu Arg Phe Asp Asp Met Ser Ser Pro Gly Leu Glu Leu
             120                 125                 130

 cca tct tgt gaa tta agt cgc ctt gaa gaa att gca gaa ctt gtg gca      967
 Pro Ser Cys Glu Leu Ser Arg Leu Glu Glu Ile Ala Glu Leu Val Ala
         135                 140                 145

 tca tct tta cct tca cct ctt cgt cgt gaa aaa ctt gca ctg gca cta     1015
 Ser Ser Leu Pro Ser Pro Leu Arg Arg Glu Lys Leu Ala Leu Ala Leu
     150                 155                 160

 gaa aat gag ggt tat att aaa aag ctc ctg gag ctt ttt cat gtg tgt     1063
 Glu Asn Glu Gly Tyr Ile Lys Lys Leu Leu Glu Leu Phe His Val Cys
 165                 170                 175                 180

 gaa gat ttg gaa aat att gaa gga ctg cac cac ttg tat gaa att atc     1111
 Glu Asp Leu Glu Asn Ile Glu Gly Leu His His Leu Tyr Glu Ile Ile
                 185                 190                 195

 aaa ggc atc ttt ctc ttg aat cga act gct ctt ttt gaa gtt atg ttc     1159
 Lys Gly Ile Phe Leu Leu Asn Arg Thr Ala Leu Phe Glu Val Met Phe
             200                 205                 210

 tct gaa gaa tgt ata atg gac gtc att gga tgt tta gaa tat gat cct     1207
 Ser Glu Glu Cys Ile Met Asp Val Ile Gly Cys Leu Glu Tyr Asp Pro
         215                 220                 225

 gct tta tca caa cca cga aaa cac agg gaa ttt cta aca aaa aca gcc     1255
 Ala Leu Ser Gln Pro Arg Lys His Arg Glu Phe Leu Thr Lys Thr Ala
     230                 235                 240

 aag ttt aaa gaa gtg att ccc ata tca gat cct gag ctg aaa caa aaa     1303
 Lys Phe Lys Glu Val Ile Pro Ile Ser Asp Pro Glu Leu Lys Gln Lys
 245                 250                 255                 260

 att cat cag aca tac aga gtt cag tat ata caa gat atg gtt cta cca     1351
 Ile His Gln Thr Tyr Arg Val Gln Tyr Ile Gln Asp Met Val Leu Pro
                 265                 270                 275

 act cct tcg gtc ttt gaa gaa aac atg tta tca aca ctt cac tct ttt     1399
 Thr Pro Ser Val Phe Glu Glu Asn Met Leu Ser Thr Leu His Ser Phe
             280                 285                 290

 atc ttt ttc aat aag gta gag att gtt ggc atg ttg cag gaa gat gaa     1447
 Ile Phe Phe Asn Lys Val Glu Ile Val Gly Met Leu Gln Glu Asp Glu
         295                 300                 305

 aaa ttt ctg aca gat ttg ttt gca caa cta aca gat gaa gca aca gat     1495
 Lys Phe Leu Thr Asp Leu Phe Ala Gln Leu Thr Asp Glu Ala Thr Asp
     310                 315                 320

 gag gaa aaa aga cag gaa ttg ggc atg gat gat aca cag gtg cga agt     1543
 Glu Glu Lys Arg Gln Glu Leu Gly Met Asp Asp Thr Gln Val Arg Ser
 325                 330                 335                 340

 gct gct act gat ata ttc tca tac ttg gtt gaa tat aat cca tcc atg     1591
 Ala Ala Thr Asp Ile Phe Ser Tyr Leu Val Glu Tyr Asn Pro Ser Met
                 345                 350                 355

 gta cga gag ttt gtc atg cag gag gca caa cag aat gat gat gat att     1639
 Val Arg Glu Phe Val Met Gln Glu Ala Gln Gln Asn Asp Asp Asp Ile
             360                 365                 370

 ttg ctc atc aac ctc att ata gaa cat atg att tgt gat aca gat cct     1687
 Leu Leu Ile Asn Leu Ile Ile Glu His Met Ile Cys Asp Thr Asp Pro
         375                 380                 385

 gaa ctt gga gga gca gtc cag ctt atg ggc ctg ctt cga act tta gtt     1735
 Glu Leu Gly Gly Ala Val Gln Leu Met Gly Leu Leu Arg Thr Leu Val
     390                 395                 400

 gac cca gag aac atg cta gcc act gcc aat aaa aca gaa aag act gaa     1783
 Asp Pro Glu Asn Met Leu Ala Thr Ala Asn Lys Thr Glu Lys Thr Glu
 405                 410                 415                 420

 ttt ctg ggt ttc ttc tac aag cac tgt atg cat gtt ctc act gct cct     1831
 Phe Leu Gly Phe Phe Tyr Lys His Cys Met His Val Leu Thr Ala Pro
                 425                 430                 435

 tta cta gca aat aca aca gaa gac aaa cct agt aaa gat gat ttt cag     1879
 Leu Leu Ala Asn Thr Thr Glu Asp Lys Pro Ser Lys Asp Asp Phe Gln
             440                 445                 450

 act gcc caa cta ttg gca ctt gta ttg gaa ttg tta aca ttt tgt gtg     1927
 Thr Ala Gln Leu Leu Ala Leu Val Leu Glu Leu Leu Thr Phe Cys Val
         455                 460                 465

 gag cac cat acc tac cac ata aag aac tac att att aat aag gat atc     1975
 Glu His His Thr Tyr His Ile Lys Asn Tyr Ile Ile Asn Lys Asp Ile
     470                 475                 480

 ctc cgg aga gtg cta gtt ctt atg gcc tcg aag cat gct ttc ttg gca     2023
 Leu Arg Arg Val Leu Val Leu Met Ala Ser Lys His Ala Phe Leu Ala
 485                 490                 495                 500

 tta tgt gcc ctt cgt ttt aaa aga aag att att gga tta aaa gat gag     2071
 Leu Cys Ala Leu Arg Phe Lys Arg Lys Ile Ile Gly Leu Lys Asp Glu
                 505                 510                 515

 ttt tac aac cgc tac ata atg aaa agt ttt ttg ttt gaa cca gta gtg     2119
 Phe Tyr Asn Arg Tyr Ile Met Lys Ser Phe Leu Phe Glu Pro Val Val
             520                 525                 530

 aaa gca ttt ctc aac aat gga tcc cgc tac aat ctg atg aac tct gcc     2167
 Lys Ala Phe Leu Asn Asn Gly Ser Arg Tyr Asn Leu Met Asn Ser Ala
         535                 540                 545

 ata ata gag atg ttt gaa ttt att aga gtg gaa gat ata aaa tca tta     2215
 Ile Ile Glu Met Phe Glu Phe Ile Arg Val Glu Asp Ile Lys Ser Leu
     550                 555                 560

 act gct cat gta att gaa aat tac tgg aaa gca ctg gaa gat gta gat     2263
 Thr Ala His Val Ile Glu Asn Tyr Trp Lys Ala Leu Glu Asp Val Asp
 565                 570                 575                 580

 tat gta cag aca ttt aaa gga tta aaa ctg aga ttt gaa caa caa aga     2311
 Tyr Val Gln Thr Phe Lys Gly Leu Lys Leu Arg Phe Glu Gln Gln Arg
                 585                 590                 595

 gaa agg caa gat aat ccc aaa ctt gac agt atg cgt tcc att ttg agg     2359
 Glu Arg Gln Asp Asn Pro Lys Leu Asp Ser Met Arg Ser Ile Leu Arg
             600                 605                 610

 aat cac aga tat cga aga gat gcc aga aca cta gaa gat gaa gaa gag     2407
 Asn His Arg Tyr Arg Arg Asp Ala Arg Thr Leu Glu Asp Glu Glu Glu
         615                 620                 625

 atg tgg ttt aac aca gat gaa gat gac atg gaa gat gga gaa gct gta     2455
 Met Trp Phe Asn Thr Asp Glu Asp Asp Met Glu Asp Gly Glu Ala Val
     630                 635                 640

 gtg tct cca tct gac aaa act aaa aat gat gat gat att atg gat cca     2503
 Val Ser Pro Ser Asp Lys Thr Lys Asn Asp Asp Asp Ile Met Asp Pro
 645                 650                 655                 660

 ata agt aaa ttc atg gaa agg aag aaa tta aaa gaa agt gag gaa aag     2551
 Ile Ser Lys Phe Met Glu Arg Lys Lys Leu Lys Glu Ser Glu Glu Lys
                 665                 670                 675

 gaa gtg ctt ctg aaa aca aac ctt tct gga cgg cag agc cca agt ttc     2599
 Glu Val Leu Leu Lys Thr Asn Leu Ser Gly Arg Gln Ser Pro Ser Phe
             680                 685                 690

 aag ctt tcc ctg tcc agt gga acg aag act aac ctc acc agc cag tca     2647
 Lys Leu Ser Leu Ser Ser Gly Thr Lys Thr Asn Leu Thr Ser Gln Ser
         695                 700                 705

 tct aca aca aat ctg cct ggt tct ccg gga tca cct gga tcc cca gga     2695
 Ser Thr Thr Asn Leu Pro Gly Ser Pro Gly Ser Pro Gly Ser Pro Gly
     710                 715                 720

 tct cca ggc tct cct gga tcc gta cct aaa aat aca tct cag acg gca     2743
 Ser Pro Gly Ser Pro Gly Ser Val Pro Lys Asn Thr Ser Gln Thr Ala
 725                 730                 735                 740

 gct att act aca aag gga ggc ctc gtg ggt ctg gta gat tat cct gat     2791
 Ala Ile Thr Thr Lys Gly Gly Leu Val Gly Leu Val Asp Tyr Pro Asp
                 745                 750                 755

 gat gat gaa gat gat gat gag gat gaa gat aag gaa gat acg tta cca     2839
 Asp Asp Glu Asp Asp Asp Glu Asp Glu Asp Lys Glu Asp Thr Leu Pro
             760                 765                 770

 ttg tca aag aaa gca aaa ttt gat tca taa t aatggcaacg gcctaggatc     2890
 Leu Ser Lys Lys Ala Lys Phe Asp Ser 
         775                 780

 agtacctgtt gaaaaaaact ggttctccac ccctccccca tacaaaatcc acaacaaagc   2950

 gcagtggtct cttgtgaatg actgacacag atcagcctct tacacttgac ttctgctcat   3010

 caagtgccaa ttcaatggag caggaggagg ggatatcata tatttagggg aaagacttaa   3070

 gcctttgagc tctccagctt ggaccacaca ttgccctttt ctcagggaag gaaatggaaa   3130

 caaaaagcca acagggcagg ggttttgtaa gtggaactct ggattgactg gtcagttgct   3190

 acaatcagaa tatgctttct tggaccatgt ttgagactca gaagaatggg cctttctgcc   3250

 ataattcttc actagtcaag aatgccagca gtttctttgt ataaagagac ctgcctttaa   3310

 aatcatacat tctgaacatt ttagtcaagc tacaacaggt ttggaaaacc tctgtggggg   3370

 aggggcgagt ataaagtttt cctctttttt aactgttccc tttgcccttc aaactgcaga   3430

 tatttttttt tttaagtggg gacttctccc tacttgatta aagattgagt ggaattctaa   3490

 aaaaaaaaaa                                                          3500




      <210> 63
      <211> 1028
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (55)..(348)

      <400> 63
 cgggcgagga gaagaggtga ccccgcgaaa gataataaat catcattgat caag  atg      57
                                                              Met
                                                                1

 tct tca gca cct gag cct cca aca ttc aaa aag gaa cca ccc aaa gaa      105
 Ser Ser Ala Pro Glu Pro Pro Thr Phe Lys Lys Glu Pro Pro Lys Glu
               5                  10                  15

 aaa gag ttt caa agc cca ggg ctc aga ggg gtg cgc aca aca acc tta      153
 Lys Glu Phe Gln Ser Pro Gly Leu Arg Gly Val Arg Thr Thr Thr Leu
          20                  25                  30

 ttt cgt gct gtg aat cca gag ctc ttc att aaa cct aac aaa cct gta      201
 Phe Arg Ala Val Asn Pro Glu Leu Phe Ile Lys Pro Asn Lys Pro Val
      35                  40                  45

 atg gct ttc gga ttg gta act ctt tca ctt tgc gtg gca tat att ggt      249
 Met Ala Phe Gly Leu Val Thr Leu Ser Leu Cys Val Ala Tyr Ile Gly
  50                  55                  60                  65

 tat cta cat gca ata caa gag aat aaa aag gac ctc tat gaa gct att      297
 Tyr Leu His Ala Ile Gln Glu Asn Lys Lys Asp Leu Tyr Glu Ala Ile
                  70                  75                  80

 gat agt gag ggg cac agt tat atg agg cgg aaa aca tcc aaa tgg gat      345
 Asp Ser Glu Gly His Ser Tyr Met Arg Arg Lys Thr Ser Lys Trp Asp
              85                  90                  95

 tag tagt gctggttagt gcagatggac ctttattaaa ggttctgaaa tcttcaaatg      402
 


 aaagaccttg tgagtgtaca gtatcatgtt tcttgttcta gaacatgcta atgaagagag    462

 aagatagcag ttgcaaccag acaactgtcg taaattttgt cctttcacag ctgcagccat    522

 tatctcattc tttttccaca gagtgagcgt cataatattt ttctttcctt acctcttata    582

 aaagtgccat gagaatggaa gttgtttttg ttaattatta aattctgtat aataaaagta    642

 cccatgctgt taaatttgca tgatgtttta aatattttaa gatgaattat gccggtgcag    702

 ctgtcgtgaa agtttacttg tgttttgcta cttgcaaagg aaatgttcat gttctccctg    762

 gcatagaacc tatattttta aagaaagata aatagaaatt ttaaggcctg aagtcaatat    822

 taaaaatatg agatatgaga aactgagttg gctctgacaa gtagttttta tagtgtcaca    882

 aatggttcat atatttcagt ttccatttta gctatttttg ggacagaatt ttattttaat    942

 ggaaaagatc cttccactca gctactaaaa taaggattaa gaatatccca gagtaattgg   1002

 agtttttctt taaaaaaaaa aaaaaa                                        1028




      <210> 64
      <211> 1003
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (140)..(976)

      <400> 64
 aaggggactc gccgcagatc cgctgtactt gcgtccgcta cagtatgtca atcgcttgcc     60

 ccagcacagc tgtcattctt ctctacagaa gagcttctcc tcatcaactg gggatgatta    120

 cagttcttcc taaaaaagg atg gct gct ctt ttt cta aag agg tta aca cta     172
                      Met Ala Ala Leu Phe Leu Lys Arg Leu Thr Leu
                        1               5                  10

 caa act gta aag tct gaa aat agt tgc att aga tgt ttt ggt aaa cac      220
 Gln Thr Val Lys Ser Glu Asn Ser Cys Ile Arg Cys Phe Gly Lys His
              15                  20                  25

 atc ctg caa aag aca gca cca gca cag ttg tcc cct att gct tct gcc      268
 Ile Leu Gln Lys Thr Ala Pro Ala Gln Leu Ser Pro Ile Ala Ser Ala
          30                  35                  40

 cca aga ctc tcc ttc cta att cat gca aaa gcc ttt agt acc gct gaa      316
 Pro Arg Leu Ser Phe Leu Ile His Ala Lys Ala Phe Ser Thr Ala Glu
      45                  50                  55

 gac acc cag aat gaa gga aaa aag aca aaa aag aat aaa aca gct ttt      364
 Asp Thr Gln Asn Glu Gly Lys Lys Thr Lys Lys Asn Lys Thr Ala Phe
  60                  65                  70                  75

 agt aac gtt gga aga aaa att agt cag cga gtt att cac tta ttt gat      412
 Ser Asn Val Gly Arg Lys Ile Ser Gln Arg Val Ile His Leu Phe Asp
                  80                  85                  90

 gag aag ggc aat gat ttg gga aac atg cac cga gca aat gtg att aga      460
 Glu Lys Gly Asn Asp Leu Gly Asn Met His Arg Ala Asn Val Ile Arg
              95                 100                 105

 ctt atg gat gag cga gac ctg cga ctg gtt caa agg aac acc agc aca      508
 Leu Met Asp Glu Arg Asp Leu Arg Leu Val Gln Arg Asn Thr Ser Thr
         110                 115                 120

 gaa cct gca gag tat cag ctc atg aca gga ttg cag atc ctc cag gag      556
 Glu Pro Ala Glu Tyr Gln Leu Met Thr Gly Leu Gln Ile Leu Gln Glu
     125                 130                 135

 cgg cag agg ctg agg gag atg gag aag gcg aac ccc aaa act gga cca      604
 Arg Gln Arg Leu Arg Glu Met Glu Lys Ala Asn Pro Lys Thr Gly Pro
 140                 145                 150                 155

 acc ctg aga aag gaa ctg att ttg tct tca aat att gga caa cat gat      652
 Thr Leu Arg Lys Glu Leu Ile Leu Ser Ser Asn Ile Gly Gln His Asp
                 160                 165                 170

 ttg gac aca aag act aaa cag att cag cag tgg att aag aaa aaa cac      700
 Leu Asp Thr Lys Thr Lys Gln Ile Gln Gln Trp Ile Lys Lys Lys His
             175                 180                 185

 cta gtc cag att acc ata aag aaa gga aaa aat gta gac gtg tca gaa      748
 Leu Val Gln Ile Thr Ile Lys Lys Gly Lys Asn Val Asp Val Ser Glu
         190                 195                 200

 aat gaa atg gag gag ata ttt cat caa ata ctc cag act atg cct gga      796
 Asn Glu Met Glu Glu Ile Phe His Gln Ile Leu Gln Thr Met Pro Gly
     205                 210                 215

 ata gct aca ttc tca tct agg cca caa gct gtt caa gga gga aaa gct      844
 Ile Ala Thr Phe Ser Ser Arg Pro Gln Ala Val Gln Gly Gly Lys Ala
 220                 225                 230                 235

 tta atg tgt gtt ctt cgt gct ttg agc aaa aat gag gag aag gca tat      892
 Leu Met Cys Val Leu Arg Ala Leu Ser Lys Asn Glu Glu Lys Ala Tyr
                 240                 245                 250

 aaa gaa act caa gag acc cag gaa aga gac act ttg aac aaa gac cat      940
 Lys Glu Thr Gln Glu Thr Gln Glu Arg Asp Thr Leu Asn Lys Asp His
             255                 260                 265

 gga aat gat aag gaa tca aat gtt ctg cat cag taa tttt aataaagaaa      990
 Gly Asn Asp Lys Glu Ser Asn Val Leu His Gln 
         270                 275

 agcatgctct gag                                                      1003




      <210> 65
      <211> 2342
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (62)..(1432)

      <400> 65
 ggtacctcct gccagcacct cttgggtttg ctgagaactc acgggctcca gctacctggc     60

 c    atg acc acc aca ttt ctg caa act tct tcc tcc acc ttt ggg ggt     106
      Met Thr Thr Thr Phe Leu Gln Thr Ser Ser Ser Thr Phe Gly Gly
        1               5                  10                  15

 ggc tca acc cga ggg ggt tcc ctc ctg gct ggg gga ggt ggc ttt ggt      154
 Gly Ser Thr Arg Gly Gly Ser Leu Leu Ala Gly Gly Gly Gly Phe Gly
                  20                  25                  30

 ggg ggg agt ctc tct ggg gga ggt gga agc cga agt atc tca gct tct      202
 Gly Gly Ser Leu Ser Gly Gly Gly Gly Ser Arg Ser Ile Ser Ala Ser
              35                  40                  45

 tct gct agg ttt gtc tct tca ggg tca gga gga gga tat ggg ggt ggc      250
 Ser Ala Arg Phe Val Ser Ser Gly Ser Gly Gly Gly Tyr Gly Gly Gly
          50                  55                  60

 atg agg gtc tgt ggc ttt ggt gga ggg gct ggt agt gtt ttc ggt gga      298
 Met Arg Val Cys Gly Phe Gly Gly Gly Ala Gly Ser Val Phe Gly Gly
      65                  70                  75

 ggc ttt gga ggg ggc gtt ggt ggg ggt ttt ggt ggt ggc ttt ggt ggt      346
 Gly Phe Gly Gly Gly Val Gly Gly Gly Phe Gly Gly Gly Phe Gly Gly
  80                  85                  90                  95

 ggc gat ggt ggt ctc ctc tct ggc aat gag aaa att acc atg cag aac      394
 Gly Asp Gly Gly Leu Leu Ser Gly Asn Glu Lys Ile Thr Met Gln Asn
                 100                 105                 110

 ctc aat gac cgc ctg gcc tcc tac ctg gac aag gta cgt gcc ctg gag      442
 Leu Asn Asp Arg Leu Ala Ser Tyr Leu Asp Lys Val Arg Ala Leu Glu
             115                 120                 125

 gag gcc aat gct gac ctg gag gtg aag atc cat gac tgg tac cag aag      490
 Glu Ala Asn Ala Asp Leu Glu Val Lys Ile His Asp Trp Tyr Gln Lys
         130                 135                 140

 cag acc cca gcc agc cca gaa tgc gac tac agc caa tac ttc aag acc      538
 Gln Thr Pro Ala Ser Pro Glu Cys Asp Tyr Ser Gln Tyr Phe Lys Thr
     145                 150                 155

 att gaa gag ctc cgg gac aag atc atg gcc acc acc atc gac aac tcc      586
 Ile Glu Glu Leu Arg Asp Lys Ile Met Ala Thr Thr Ile Asp Asn Ser
 160                 165                 170                 175

 cgg gtc atc ctg gag atc gac aat gcc agg ctg gct gcg gac gac ttc      634
 Arg Val Ile Leu Glu Ile Asp Asn Ala Arg Leu Ala Ala Asp Asp Phe
                 180                 185                 190

 agg ctc aag tat gag aat gag ctg gcc ctg cgc cag ggc gtt gag gct      682
 Arg Leu Lys Tyr Glu Asn Glu Leu Ala Leu Arg Gln Gly Val Glu Ala
             195                 200                 205

 gac atc aac ggc ttg cgc cga gtc ctg gat gag ctg acc ctg gcc agg      730
 Asp Ile Asn Gly Leu Arg Arg Val Leu Asp Glu Leu Thr Leu Ala Arg
         210                 215                 220

 act gac ctg gag atg cag atc gag ggc ctg aat gag gag cta gcc tac      778
 Thr Asp Leu Glu Met Gln Ile Glu Gly Leu Asn Glu Glu Leu Ala Tyr
     225                 230                 235

 ctg aag aag aac cac gaa gag gag atg aag gag ttc agc agc cag ctg      826
 Leu Lys Lys Asn His Glu Glu Glu Met Lys Glu Phe Ser Ser Gln Leu
 240                 245                 250                 255

 gcc ggc cag gtc aat gtg gag atg gac gca gca ccg ggt gtg gac ctg      874
 Ala Gly Gln Val Asn Val Glu Met Asp Ala Ala Pro Gly Val Asp Leu
                 260                 265                 270

 acc cgt gtg ctg gca gag atg agg gag cag tac gag gcc atg gcg gag      922
 Thr Arg Val Leu Ala Glu Met Arg Glu Gln Tyr Glu Ala Met Ala Glu
             275                 280                 285

 aag aac cgc cgg gat gtc gag gcc tgg ttc ttc agc aag act gag gag      970
 Lys Asn Arg Arg Asp Val Glu Ala Trp Phe Phe Ser Lys Thr Glu Glu
         290                 295                 300

 ctg aac aaa gag gtg gcc tcc aac aca gaa atg atc cag acc agc aag     1018
 Leu Asn Lys Glu Val Ala Ser Asn Thr Glu Met Ile Gln Thr Ser Lys
     305                 310                 315

 acg gag atc aca gac ctg aga cgc acg atg cag gag ctg gag atc gag     1066
 Thr Glu Ile Thr Asp Leu Arg Arg Thr Met Gln Glu Leu Glu Ile Glu
 320                 325                 330                 335

 ctg cag tcc cag ctc agc atg aaa gct ggg ctg gag aac tca ctg gcc     1114
 Leu Gln Ser Gln Leu Ser Met Lys Ala Gly Leu Glu Asn Ser Leu Ala
                 340                 345                 350

 gag aca gag tgc cgc tat gcc acg cag ctg cag cag atc cag ggg ctc     1162
 Glu Thr Glu Cys Arg Tyr Ala Thr Gln Leu Gln Gln Ile Gln Gly Leu
             355                 360                 365

 att ggt ggc ctg gag gcc cag ctg agt gag ctc cga tgc gag atg gag     1210
 Ile Gly Gly Leu Glu Ala Gln Leu Ser Glu Leu Arg Cys Glu Met Glu
         370                 375                 380

 gct cag aac cag gag tac aag atg ctg ctt gac ata aag aca cgg ctg     1258
 Ala Gln Asn Gln Glu Tyr Lys Met Leu Leu Asp Ile Lys Thr Arg Leu
     385                 390                 395

 gag cag gag atc gct act tac cgc agc ctg ctc gag ggc cag gat gcc     1306
 Glu Gln Glu Ile Ala Thr Tyr Arg Ser Leu Leu Glu Gly Gln Asp Ala
 400                 405                 410                 415

 aag atg gct ggc att ggc atc agg gaa gcc tct tca gga ggt ggt ggt     1354
 Lys Met Ala Gly Ile Gly Ile Arg Glu Ala Ser Ser Gly Gly Gly Gly
                 420                 425                 430

 agc agc agc aat ttc cac atc aat gta gaa gag tca gtg gat gga cag     1402
 Ser Ser Ser Asn Phe His Ile Asn Val Glu Glu Ser Val Asp Gly Gln
             435                 440                 445

 gtg gtt tct tcc cac aag aga gaa atc taa g tgtctattgc aggagaaacg     1453
 Val Val Ser Ser His Lys Arg Glu Ile 
         450                 455

 tcccttgcca ctccccactc tcatcaggcc aagtggagga ctggccagag ggcctgcaca   1513

 tgcaaactcc agtccctgcc ttcagagagc tgaaaagggt ccctcggtct tttatttcag   1573

 ggctttgcat gcgctctatt ccccctctgc ctctccccac cttctttgga gcaaggagat   1633

 gcagatcgag ggcctgaatg aggagctagc ctacctgaag aagaaccacg aagagtgggt   1693

 ccctcccatc ctgcaggaga tgaaggagtt cagcagccag ctggccggcc aggtcaatgt   1753

 ggagatggac gcagcaccgg gtgtggacct gacccgtgtg ctggcagaga tgagggagca   1813

 gtacgaggcc atggcggaga agaaccgccg ggatgtcgag gcctggttct tcagcaagac   1873

 tgaggagctg aacaaagagg tggcctccaa cacagaaatg atccagacca gcaagacgga   1933

 gatcacagac ctgagacgca cgatgcagga gctggagatc gagctgcagt cccagctcag   1993

 catgaaagct gggctggaga actcactggc cgagacagag tgccgctatg ccacgcagct   2053

 gcagcagatc caggggctca ttggtggcct ggaggcccag ctgagtgagc tccgatgcga   2113

 gatggaggct cagaaccagg agtacaagat gctgcttgac ataaagacac ggctggagca   2173

 ggagatcgct acttaccgca gcctgctcga gggccaggat gccaagatgg ctggcattgc   2233

 catcagggaa gcctcttcag gaggtggtgg tagcagcagc aatttccaca tcaatgtaga   2293

 agagtcagtg gatggacagg tggtttcttc ccacaagaga gaaatctaa               2342




      <210> 66
      <211> 2662
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (75)..(2633)

      <400> 66
 gcggtcccta attcccgggt cgacgatttc gtagatccac agctaagacg ccgggactcc     60

 ctgttttcct ataa  atg gaa cca ctg aca ttt aaa gat gtc gcc ata gaa     110
                  Met Glu Pro Leu Thr Phe Lys Asp Val Ala Ile Glu
                    1               5                  10

 ttc tct ctg gag gag tgg caa tgc ctg gat act gca cag cgg gat tta      158
 Phe Ser Leu Glu Glu Trp Gln Cys Leu Asp Thr Ala Gln Arg Asp Leu
          15                  20                  25

 tat agg aat gtg ttg tta gag aac tac aga aac ctg gtc ttt ttg ggt      206
 Tyr Arg Asn Val Leu Leu Glu Asn Tyr Arg Asn Leu Val Phe Leu Gly
      30                  35                  40

 att gct gtc tct aag cca tat ctg atc acc tgt ctg gag caa aaa aaa      254
 Ile Ala Val Ser Lys Pro Tyr Leu Ile Thr Cys Leu Glu Gln Lys Lys
  45                  50                  55                  60

 gag ccc tgg aat ata aaa aga cat gag atg gta gcc aaa ccc cca gta      302
 Glu Pro Trp Asn Ile Lys Arg His Glu Met Val Ala Lys Pro Pro Val
                  65                  70                  75

 atg tct ttt cat ttt gcc caa gac ctt tgg cca gag cag aac ata aaa      350
 Met Ser Phe His Phe Ala Gln Asp Leu Trp Pro Glu Gln Asn Ile Lys
              80                  85                  90

 gat tct ttc cag aaa gtg aca ctg aga aga tac gga aaa tgt gaa tat      398
 Asp Ser Phe Gln Lys Val Thr Leu Arg Arg Tyr Gly Lys Cys Glu Tyr
          95                 100                 105

 gag aat tta cag tta agg aaa ggc tgt aaa cat gtg gat gag tgt acg      446
 Glu Asn Leu Gln Leu Arg Lys Gly Cys Lys His Val Asp Glu Cys Thr
     110                 115                 120

 ggg cac aaa gga ggt cat aat aca gtt aac caa tgt ttg aca gct acc      494
 Gly His Lys Gly Gly His Asn Thr Val Asn Gln Cys Leu Thr Ala Thr
 125                 130                 135                 140

 cca agc aaa ata ttc cag tgt aat aaa tat gtg aaa gtc ttt gat aaa      542
 Pro Ser Lys Ile Phe Gln Cys Asn Lys Tyr Val Lys Val Phe Asp Lys
                 145                 150                 155

 ttt tca aat tca aat aga tat aag aga aga cat aca gga aac aaa cac      590
 Phe Ser Asn Ser Asn Arg Tyr Lys Arg Arg His Thr Gly Asn Lys His
             160                 165                 170

 ttc aaa tgt aaa gaa tgt agc aaa tca ttt tgc gtg ctt tca caa cta      638
 Phe Lys Cys Lys Glu Cys Ser Lys Ser Phe Cys Val Leu Ser Gln Leu
         175                 180                 185

 act cag cat aga aga att cat act aga gtg aat tcc tac aaa tgt gaa      686
 Thr Gln His Arg Arg Ile His Thr Arg Val Asn Ser Tyr Lys Cys Glu
     190                 195                 200

 gaa tgt gga aaa gcc ttt aac tgg ttc tca act ctt act aaa cat aag      734
 Glu Cys Gly Lys Ala Phe Asn Trp Phe Ser Thr Leu Thr Lys His Lys
 205                 210                 215                 220

 aga att cat act gga gaa aag ccc tac aaa tgt gaa gaa tgt ggc aaa      782
 Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys
                 225                 230                 235

 gcc ttt aac cag tcc tca caa ctt act agg cat aag ata att cat act      830
 Ala Phe Asn Gln Ser Ser Gln Leu Thr Arg His Lys Ile Ile His Thr
             240                 245                 250

 gaa gag aaa ccc aac aaa tgt gaa gaa tgt ggc aag gcc ttt aaa cag      878
 Glu Glu Lys Pro Asn Lys Cys Glu Glu Cys Gly Lys Ala Phe Lys Gln
         255                 260                 265

 gcc tca cac ctt act ata cat aaa ata att cat act gga gaa aaa cct      926
 Ala Ser His Leu Thr Ile His Lys Ile Ile His Thr Gly Glu Lys Pro
     270                 275                 280

 tac aaa tat gaa gaa tgt ggc aaa gtc ttt agc cag tcc tca cac ctt      974
 Tyr Lys Tyr Glu Glu Cys Gly Lys Val Phe Ser Gln Ser Ser His Leu
 285                 290                 295                 300

 act aca caa aag ata ctt cac act gga gag aac ctc tac aag tgt aaa     1022
 Thr Thr Gln Lys Ile Leu His Thr Gly Glu Asn Leu Tyr Lys Cys Lys
                 305                 310                 315

 gaa tgt gga aaa gct ttt aac cta ttc tca aat ctt act aac cat aag     1070
 Glu Cys Gly Lys Ala Phe Asn Leu Phe Ser Asn Leu Thr Asn His Lys
             320                 325                 330

 aga att cat gct ggg gag aaa ccc tac aaa tgt aaa gaa tgt ggc aga     1118
 Arg Ile His Ala Gly Glu Lys Pro Tyr Lys Cys Lys Glu Cys Gly Arg
         335                 340                 345

 gct ttt aac ata tcc tca aac ctt aat aaa cag gag aaa att cat act     1166
 Ala Phe Asn Ile Ser Ser Asn Leu Asn Lys Gln Glu Lys Ile His Thr
     350                 355                 360

 gga ggg aaa ctc aac aaa tgt gaa gaa tgt gac aaa gct ttt aac cga     1214
 Gly Gly Lys Leu Asn Lys Cys Glu Glu Cys Asp Lys Ala Phe Asn Arg
 365                 370                 375                 380

 tcc tta aaa ctt act gca cat aag aaa att cta atg gaa gag aaa ccc     1262
 Ser Leu Lys Leu Thr Ala His Lys Lys Ile Leu Met Glu Glu Lys Pro
                 385                 390                 395

 tac aaa tgt gaa gaa tgt ggc aaa gtc ttt aac cag ttc tca act ctt     1310
 Tyr Lys Cys Glu Glu Cys Gly Lys Val Phe Asn Gln Phe Ser Thr Leu
             400                 405                 410

 act aga cat aag ata att cat act gga gag aaa ccc tac aaa tgt aaa     1358
 Thr Arg His Lys Ile Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Lys
         415                 420                 425

 gaa tgt ggc aaa gct ttt aac caa tct tca aac ctt act gaa cat aag     1406
 Glu Cys Gly Lys Ala Phe Asn Gln Ser Ser Asn Leu Thr Glu His Lys
     430                 435                 440

 aaa att cat act gca gag aaa tcc tat aaa tgt gaa gaa tgt ggc aaa     1454
 Lys Ile His Thr Ala Glu Lys Ser Tyr Lys Cys Glu Glu Cys Gly Lys
 445                 450                 455                 460

 gct ttt aac caa cac tca aac cta att aac cat agg aaa att tat tct     1502
 Ala Phe Asn Gln His Ser Asn Leu Ile Asn His Arg Lys Ile Tyr Ser
                 465                 470                 475

 gga gag aaa cca tac aaa tgt gaa gaa tgt gga aaa gct ttt aat cga     1550
 Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Asn Arg
             480                 485                 490

 tcc tca acc ctt act aga cat aag aaa att cat act gga gag aaa ccc     1598
 Ser Ser Thr Leu Thr Arg His Lys Lys Ile His Thr Gly Glu Lys Pro
         495                 500                 505

 tac aaa tgt gaa gaa tgt gac aga gct ttt agc cag tct tca aac ctt     1646
 Tyr Lys Cys Glu Glu Cys Asp Arg Ala Phe Ser Gln Ser Ser Asn Leu
     510                 515                 520

 act gaa cat aag aaa att cat act gga gag aaa ccc tat aaa tgt gag     1694
 Thr Glu His Lys Lys Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu
 525                 530                 535                 540

 gaa tgt ggc aaa gct ttt aac cga ttc tca acc ctt act aaa cat aag     1742
 Glu Cys Gly Lys Ala Phe Asn Arg Phe Ser Thr Leu Thr Lys His Lys
                 545                 550                 555

 aga att cat act gga gaa aaa ccc tat aaa tgt gaa gaa tgt gga aaa     1790
 Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys
             560                 565                 570

 gcc ttt aat caa tcc tat caa ctt act aga cat aag ata gtt cat act     1838
 Ala Phe Asn Gln Ser Tyr Gln Leu Thr Arg His Lys Ile Val His Thr
         575                 580                 585

 aaa gag aaa ctc aac aaa tgt gaa gaa ttt ggc aag gcc ttt aaa cag     1886
 Lys Glu Lys Leu Asn Lys Cys Glu Glu Phe Gly Lys Ala Phe Lys Gln
     590                 595                 600

 tcc tca cac cgt act ata cat aaa att att cat act gga gag aaa ccc     1934
 Ser Ser His Arg Thr Ile His Lys Ile Ile His Thr Gly Glu Lys Pro
 605                 610                 615                 620

 tac aaa tgt gaa gaa cat ggc aaa gtt ttt aac cag tcc tca aac ctt     1982
 Tyr Lys Cys Glu Glu His Gly Lys Val Phe Asn Gln Ser Ser Asn Leu
                 625                 630                 635

 act aca caa aag ata att cat act gga gag aac ctc tac aaa ttt gaa     2030
 Thr Thr Gln Lys Ile Ile His Thr Gly Glu Asn Leu Tyr Lys Phe Glu
             640                 645                 650

 gaa cat gga aaa gct ttt aac cta ttc tca aac att act aac cat aag     2078
 Glu His Gly Lys Ala Phe Asn Leu Phe Ser Asn Ile Thr Asn His Lys
         655                 660                 665

 ata att tat act gga gag aaa ccc cac aaa tgt gaa gaa tgt gga aaa     2126
 Ile Ile Tyr Thr Gly Glu Lys Pro His Lys Cys Glu Glu Cys Gly Lys
     670                 675                 680

 gct tat aac cga ttc tca aac cta act ata cat aag aga att cat acg     2174
 Ala Tyr Asn Arg Phe Ser Asn Leu Thr Ile His Lys Arg Ile His Thr
 685                 690                 695                 700

 gga gag aaa cct tac caa tgt gca gaa tgt ggc aaa gcc ttt aac tgc     2222
 Gly Glu Lys Pro Tyr Gln Cys Ala Glu Cys Gly Lys Ala Phe Asn Cys
                 705                 710                 715

 tcc tca acc ctt aat aga cat aag ata att cat act gga gag aaa cct     2270
 Ser Ser Thr Leu Asn Arg His Lys Ile Ile His Thr Gly Glu Lys Pro
             720                 725                 730

 tac aaa tgt aaa gaa tgt ggc aaa gct ttt aac cta tcc tca acc ctt     2318
 Tyr Lys Cys Lys Glu Cys Gly Lys Ala Phe Asn Leu Ser Ser Thr Leu
         735                 740                 745

 act gca cat aag aaa att cat act gga gag aaa ccc tat aaa tgt gaa     2366
 Thr Ala His Lys Lys Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu
     750                 755                 760

 gaa tgt ggc aaa gct ttt aac caa tcc tca aac ctt acc aca cat aag     2414
 Glu Cys Gly Lys Ala Phe Asn Gln Ser Ser Asn Leu Thr Thr His Lys
 765                 770                 775                 780

 aaa att cat act tca gag aaa ccc tac aaa tgt gaa gaa tgt ggc aaa     2462
 Lys Ile His Thr Ser Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys
                 785                 790                 795

 tcc ttt aac cag ttc tca tct ctt aat ata cat aag ata att cat act     2510
 Ser Phe Asn Gln Phe Ser Ser Leu Asn Ile His Lys Ile Ile His Thr
             800                 805                 810

 gga gag aaa ccc tac aaa tgt gga gat tat ggc aga gct ttc aac cta     2558
 Gly Glu Lys Pro Tyr Lys Cys Gly Asp Tyr Gly Arg Ala Phe Asn Leu
         815                 820                 825

 tcc tca aat ctt act aca cat aag aaa att cat act gga gag aaa ccc     2606
 Ser Ser Asn Leu Thr Thr His Lys Lys Ile His Thr Gly Glu Lys Pro
     830                 835                 840

 tac aaa tgt gaa tat ggc aaa act taa tttga tcctacaggt taattacact     2658
 Tyr Lys Cys Glu Tyr Gly Lys Thr 
 845                 850

 tagg                                                                2662




      <210> 67
      <211> 733
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (153)..(413)

      <400> 67
 ccagtgcgtg gaattcgaaa ggtcatagtc ctgtttggcg gccatttctc ttgaaactgc     60

 ggctcgggac ctgcggtacc tgctgtagtc acgagggacg ggcggcggcc tggtcggcag    120

 agagtagcct gcaacattcg gccgtggtta cg  atg agt tta ccc ctc aat ccc     173
                                      Met Ser Leu Pro Leu Asn Pro
                                        1               5

 aaa cct ttc ctc aat gga cta aca gga aag cca gtg atg gtg aaa ctt      221
 Lys Pro Phe Leu Asn Gly Leu Thr Gly Lys Pro Val Met Val Lys Leu
          10                  15                  20

 aag tgg gga atg gag tac aag ggc tat ctg gta tct gta gat ggc tac      269
 Lys Trp Gly Met Glu Tyr Lys Gly Tyr Leu Val Ser Val Asp Gly Tyr
      25                  30                  35

 atg aac atg cag ctt gca aat aca gaa gaa tac ata gat gga gct ttg      317
 Met Asn Met Gln Leu Ala Asn Thr Glu Glu Tyr Ile Asp Gly Ala Leu
  40                  45                  50                  55

 tct gga cat ctg ggt gaa gtt tta ata agg tgt aat aat gtc ctt tat      365
 Ser Gly His Leu Gly Glu Val Leu Ile Arg Cys Asn Asn Val Leu Tyr
                  60                  65                  70

 atc aga ggt gtg gaa gaa gag gaa gaa gat ggg gaa atg aga gaa tag      413
 Ile Arg Gly Val Glu Glu Glu Glu Glu Asp Gly Glu Met Arg Glu 
              75                  80                  85

 catcttttgt gggggatttt ttttatatat atttctagac aataaagatt tgtttgtttt    473

 tcaacttgaa aaaaaatccc ccacaaaaga tgctattctc tcatttcccc atcttcttcc    533

 tcttcttcca cacctctgat ataaaggaca ttattacacc ttattaaaac ttcacccaga    593

 tgtccagaca aagctccatc tatgtattct tctgtatttg caagctgcat gttcatgtag    653

 ccatctacag ataccagata gcccttgtac tccattcccc acttaagttt caccatcact    713

 ggctttcctg ttagtccatg                                                733




      <210> 68
      <211> 899
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (11)..(211)

      <220>
      <221> misc_feature
      <222> (1)...(899)
      <223> n = a,t,c or g

      <400> 68
 gaacaatttt   atg cca aca aat tat aca act tgg atg aaa tgg aca att      49
              Met Pro Thr Asn Tyr Thr Thr Trp Met Lys Trp Thr Ile
                1               5                  10

 att ttt gag atg gag tct tgc tct gtt gcc ctg gct gga atg cag tgg       97
 Ile Phe Glu Met Glu Ser Cys Ser Val Ala Leu Ala Gly Met Gln Trp
      15                  20                  25

 tac aat cac ggc ttc ctc caa cct ccg ctt ccc agg ctc aag caa tcc      145
 Tyr Asn His Gly Phe Leu Gln Pro Pro Leu Pro Arg Leu Lys Gln Ser
  30                  35                  40                  45

 tgc ctc agc ctc cct agc agc tgg gac tct gct cag cgc tcc gga cgc      193
 Cys Leu Ser Leu Pro Ser Ser Trp Asp Ser Ala Gln Arg Ser Gly Arg
                  50                  55                  60

 ctg cag tca cta tgg taa cggcca acgacttccg gaagaagaac ggcgggcggc      247
 Leu Gln Ser Leu Trp 
              65

 gagggtcatt cccagccgca aactgagtgc gctgagcggg gaagcgcaaa ggggcaagtt    307

 acccgtcctg gcgtttctgg ggttcgcctc ggaggctagc ctcggtgctc tcgcaggctc    367

 gctcgcttct gcatccccgt tgccgcccgg agccaactct taagttctgg acgccaggcc    427

 tgaggcagtt ccgccatgga cttctccaag ttcctggcag acgacttcga cgtgaaggag    487

 tggatcaatg cggccttcag ggccggctcc aaggaggcgg cgtccgggaa ggcggatggc    547

 cacgcagcca ccctggtgat gaagctgcag ctgttcatcc aagaggtgaa ccacgccgtg    607

 gaggaaacaa gtcaccaagc tctccagaac atgcccaaag tgctccgtga tgttgaagcc    667

 ctaaaacagg aggcatcttt cctgaaagaa cagatgattc ttgtcaagga ggacattaaa    727

 aaatttgaac aggacacatc tcaatccatg caggtggtgg tagaaattga ccaagtgaag    787

 gccagaatgc aacttgctgg cgaatctctt cangaggcag ataagtggag gacgttgagc    847

 gccgatattg gggagacatt taagacctca gacatagctg ggattctggc cg            899




      <210> 69
      <211> 5468
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (610)..(5259)

      <400> 69
 atggggcaga agctgctgac atgcgctttg ggggtaatcc cccagcctca gcccagccca     60

 ggcctggggc ctgggttcag agagcgacga gcttccgagg cagcagccgg cctagggcta    120

 gggctgacag acgggaccag gagctctcga ggtgtctgga ggctcagcgg cagggacgaa    180

 gaaggagggc actctctctt gtccctgccc cgcctgaact tcctgtgcca ggctccgggc    240

 atgaccctca cagccacggg cctgggacag agagctgatg acccaggaga ccccctctac    300

 taccacctac aaggttcagg cttctcgtgt ccccagctca ggactctgtg ctgtgtatca    360

 gtcctggagc gccggaccca ggaggcccaa ggagctggag gtgaccctca ggcagcaaga    420

 accccacgga agggcgtgag ccctgcagac agctgtgcgg cacctcgggc tgggctcctg    480

 ttaggaggaa gtgcctgcac ccaggcagcg gctcagaggc agctgctcca tgcagaactg    540

 aagctggttc tgcagcagaa aggggagagg acacaggagc ctggggtgca ggtgcctccc    600

 agcaacgcc    atg gag gcc agg agc cgg agt gcc gag ccc gcc ctc cga     648
              Met Glu Ala Arg Ser Arg Ser Ala Glu Pro Ala Leu Arg
                1               5                  10

 ctg aca gcc aaa gac tgg ata cca cga cac tca atc aca act caa gat      696
 Leu Thr Ala Lys Asp Trp Ile Pro Arg His Ser Ile Thr Thr Gln Asp
      15                  20                  25

 tat ctc cag acc aca ccg aca aca gac cca tcc acc ata tac aac ccc      744
 Tyr Leu Gln Thr Thr Pro Thr Thr Asp Pro Ser Thr Ile Tyr Asn Pro
  30                  35                  40                  45

 gat ata cat cca ata acc aca cta tcg aga ata gac gaa cac aga gac      792
 Asp Ile His Pro Ile Thr Thr Leu Ser Arg Ile Asp Glu His Arg Asp
                  50                  55                  60

 acg gaa gag gca cca gaa cgg acc gca gga gct aga aaa acc aga acc      840
 Thr Glu Glu Ala Pro Glu Arg Thr Ala Gly Ala Arg Lys Thr Arg Thr
              65                  70                  75

 aga gag atc cta gaa agc cag ctg ccc tca ggc ttg ctt aaa ggg gag      888
 Arg Glu Ile Leu Glu Ser Gln Leu Pro Ser Gly Leu Leu Lys Gly Glu
          80                  85                  90

 acg ccg gag tgg gag ctg agg cgg gcg gag ttg gtg gaa att atc gtg      936
 Thr Pro Glu Trp Glu Leu Arg Arg Ala Glu Leu Val Glu Ile Ile Val
      95                 100                 105

 gag acg gag gcg cag acc ggg gtc agc ggc atc aac gta gcg ggc ggc      984
 Glu Thr Glu Ala Gln Thr Gly Val Ser Gly Ile Asn Val Ala Gly Gly
 110                 115                 120                 125

 ggc aaa gag gga atc ttc gtt cgg gag ctg cgc gag gac tca ccc gcc     1032
 Gly Lys Glu Gly Ile Phe Val Arg Glu Leu Arg Glu Asp Ser Pro Ala
                 130                 135                 140

 gcc agg agc ctc agc ctg cag gaa ggg gac cag ctg ctg agt gcc cga     1080
 Ala Arg Ser Leu Ser Leu Gln Glu Gly Asp Gln Leu Leu Ser Ala Arg
             145                 150                 155

 gtg ttc ttc gag aac ttc aag tac gag gac gca cta cgc ctg ctg caa     1128
 Val Phe Phe Glu Asn Phe Lys Tyr Glu Asp Ala Leu Arg Leu Leu Gln
         160                 165                 170

 tgc gcc gag cct tac aaa gtc tcc ttc tgc ctg aag cgc act gtg ccc     1176
 Cys Ala Glu Pro Tyr Lys Val Ser Phe Cys Leu Lys Arg Thr Val Pro
     175                 180                 185

 acc ggg gac ctg gct ctg cgg ccc ggg acc gtg tct ggc tac gag atc     1224
 Thr Gly Asp Leu Ala Leu Arg Pro Gly Thr Val Ser Gly Tyr Glu Ile
 190                 195                 200                 205

 aag ggc ccg cgg gcc aag gtg gcc aag ctg aac atc cag agt ctg tcc     1272
 Lys Gly Pro Arg Ala Lys Val Ala Lys Leu Asn Ile Gln Ser Leu Ser
                 210                 215                 220

 cct gtg aag aag aag aag atg gtg cct ggg gct ctg ggg gtc ccc gct     1320
 Pro Val Lys Lys Lys Lys Met Val Pro Gly Ala Leu Gly Val Pro Ala
             225                 230                 235

 gac ctg gcc cct gtt gac gtc gag ttc tcc ttt ccc aag ttc tcc cgc     1368
 Asp Leu Ala Pro Val Asp Val Glu Phe Ser Phe Pro Lys Phe Ser Arg
         240                 245                 250

 ctg cgt cgg ggc ctc aaa gcc gag gct gtc aag ggt cct gtc ccg gct     1416
 Leu Arg Arg Gly Leu Lys Ala Glu Ala Val Lys Gly Pro Val Pro Ala
     255                 260                 265

 gcc cct gcc cgc cgg cgc ctc cag ctg cct cgg ctg cgt gta cga gaa     1464
 Ala Pro Ala Arg Arg Arg Leu Gln Leu Pro Arg Leu Arg Val Arg Glu
 270                 275                 280                 285

 gtg gcc gaa gag gct cag gca gcc cgg ctg gcc gcc gcc gct cct ccc     1512
 Val Ala Glu Glu Ala Gln Ala Ala Arg Leu Ala Ala Ala Ala Pro Pro
                 290                 295                 300

 ccc agg aaa gcc aag gtg gag gct gag gtg gct gca gga gct cgt ttc     1560
 Pro Arg Lys Ala Lys Val Glu Ala Glu Val Ala Ala Gly Ala Arg Phe
             305                 310                 315

 aca gcc cct cag gtg gag ctg gtt ggg ccg cgg ctg cca ggg gcg gag     1608
 Thr Ala Pro Gln Val Glu Leu Val Gly Pro Arg Leu Pro Gly Ala Glu
         320                 325                 330

 gtg ggt gtc ccc cag gtc tca gcc ccc aag gct gcc ccc tca gca gag     1656
 Val Gly Val Pro Gln Val Ser Ala Pro Lys Ala Ala Pro Ser Ala Glu
     335                 340                 345

 gca gct ggt ggc ttt gcc ctc cac ctg cca acc ctt ggg ctc gga gcc     1704
 Ala Ala Gly Gly Phe Ala Leu His Leu Pro Thr Leu Gly Leu Gly Ala
 350                 355                 360                 365

 ccg gct ccg cct gct gtg gag gcc cca gcc gtg gga atc cag gtc ccc     1752
 Pro Ala Pro Pro Ala Val Glu Ala Pro Ala Val Gly Ile Gln Val Pro
                 370                 375                 380

 cag gtg gag ctg cct gcc ttg ccc tca ctg ccc act ctg ccc aca ctt     1800
 Gln Val Glu Leu Pro Ala Leu Pro Ser Leu Pro Thr Leu Pro Thr Leu
             385                 390                 395

 ccc tgc cta gag acc cgg gaa ggg gct gtg tcg gta gtg gtg ccc acc     1848
 Pro Cys Leu Glu Thr Arg Glu Gly Ala Val Ser Val Val Val Pro Thr
         400                 405                 410

 ctg gat gtg gca gca ccg act gtg ggg gtg gac ctg gcc ttg ccg ggt     1896
 Leu Asp Val Ala Ala Pro Thr Val Gly Val Asp Leu Ala Leu Pro Gly
     415                 420                 425

 gca gag gtg gag gcc cgg gga gag gca cct gag gtg gcc ctg aag atg     1944
 Ala Glu Val Glu Ala Arg Gly Glu Ala Pro Glu Val Ala Leu Lys Met
 430                 435                 440                 445

 ccc cgc ctt agt ttt ccc cga ttt ggg gct cga gca aag gaa gtt gct     1992
 Pro Arg Leu Ser Phe Pro Arg Phe Gly Ala Arg Ala Lys Glu Val Ala
                 450                 455                 460

 gag gcc aag gta gcc aag gtc agc cct gag gcc agg gtg aaa ggt ccc     2040
 Glu Ala Lys Val Ala Lys Val Ser Pro Glu Ala Arg Val Lys Gly Pro
             465                 470                 475

 aga ctt cga atg ccc acc ttt ggg ctt tcc ctc ttg gag ccc cgg ccc     2088
 Arg Leu Arg Met Pro Thr Phe Gly Leu Ser Leu Leu Glu Pro Arg Pro
         480                 485                 490

 gct gct cct gaa gtt gta gag agc aag ctg aag ctg ccc acc atc aag     2136
 Ala Ala Pro Glu Val Val Glu Ser Lys Leu Lys Leu Pro Thr Ile Lys
     495                 500                 505

 atg ccc tcc ctt ggc atc gga gtg tca ggg ccc gag gtc aag gtg ccc     2184
 Met Pro Ser Leu Gly Ile Gly Val Ser Gly Pro Glu Val Lys Val Pro
 510                 515                 520                 525

 aag gga cct gaa gtg aag ctc ccc aag gct cct gag gtc aag ctt cca     2232
 Lys Gly Pro Glu Val Lys Leu Pro Lys Ala Pro Glu Val Lys Leu Pro
                 530                 535                 540

 aaa gtg ccc gag gca gcc ctt cca gag gtt cga ctc cca gag gtg gag     2280
 Lys Val Pro Glu Ala Ala Leu Pro Glu Val Arg Leu Pro Glu Val Glu
             545                 550                 555

 ctc ccc aag gtg tca gag atg aaa ctc cca aag gtg cca gag atg gct     2328
 Leu Pro Lys Val Ser Glu Met Lys Leu Pro Lys Val Pro Glu Met Ala
         560                 565                 570

 gtg ccg gag gtg cgg ctt cca gag gta gag ctg ccc aaa gtg tca gag     2376
 Val Pro Glu Val Arg Leu Pro Glu Val Glu Leu Pro Lys Val Ser Glu
     575                 580                 585

 atg aaa ctc cca aag gtg cca gag atg gct gtg ccg gag gtg cgg ctt     2424
 Met Lys Leu Pro Lys Val Pro Glu Met Ala Val Pro Glu Val Arg Leu
 590                 595                 600                 605

 cca gag gta cag ctg ctg aaa gtg tcg gag atg aaa ctc cca aag gtg     2472
 Pro Glu Val Gln Leu Leu Lys Val Ser Glu Met Lys Leu Pro Lys Val
                 610                 615                 620

 cca gag atg gct gtg ccg gag gtg cgg ctt cca gag gta cag ctg ccg     2520
 Pro Glu Met Ala Val Pro Glu Val Arg Leu Pro Glu Val Gln Leu Pro
             625                 630                 635

 aaa gtg tca gag atg aaa ctc cca gag gtg tca gag gtg gct gtg cca     2568
 Lys Val Ser Glu Met Lys Leu Pro Glu Val Ser Glu Val Ala Val Pro
         640                 645                 650

 gag gtg cgg ctt cca gag gtg cag ctg ccg aaa gtg cca gag atg aaa     2616
 Glu Val Arg Leu Pro Glu Val Gln Leu Pro Lys Val Pro Glu Met Lys
     655                 660                 665

 gtc cct gag atg aag ctt cca aag gtg cct gag atg aaa ctt cct gag     2664
 Val Pro Glu Met Lys Leu Pro Lys Val Pro Glu Met Lys Leu Pro Glu
 670                 675                 680                 685

 atg aaa ctc cct gaa gtg caa ctc ccg aag gtg ccc gag atg gcc gtg     2712
 Met Lys Leu Pro Glu Val Gln Leu Pro Lys Val Pro Glu Met Ala Val
                 690                 695                 700

 ccc gat gtg cac ctc cca gaa gtg cag ctt cca aaa gtc cca gag atg     2760
 Pro Asp Val His Leu Pro Glu Val Gln Leu Pro Lys Val Pro Glu Met
             705                 710                 715

 aag ctc cct gag atg aaa ctc cct gag gtg aaa ctc ccg aag gtg ccc     2808
 Lys Leu Pro Glu Met Lys Leu Pro Glu Val Lys Leu Pro Lys Val Pro
         720                 725                 730

 gag atg gct gtg ccc gat gtg cac ctc ccg gaa gtg cag ctc ccg aaa     2856
 Glu Met Ala Val Pro Asp Val His Leu Pro Glu Val Gln Leu Pro Lys
     735                 740                 745

 gtc cca gag atg aaa ctc cct aaa atg cct gag atg gct gtg cca gag     2904
 Val Pro Glu Met Lys Leu Pro Lys Met Pro Glu Met Ala Val Pro Glu
 750                 755                 760                 765

 gtt cga ctc ccc gag gtg cag ctg cca aaa gtc tca gag atg aaa ctc     2952
 Val Arg Leu Pro Glu Val Gln Leu Pro Lys Val Ser Glu Met Lys Leu
                 770                 775                 780

 ccc aag gtg cct gaa atg gcc gtg ccc gat gtg cac ctc cca gag gtg     3000
 Pro Lys Val Pro Glu Met Ala Val Pro Asp Val His Leu Pro Glu Val
             785                 790                 795

 cag ctg ccc aaa gtc tgt gaa atg aaa gtc cct gac atg aag ctc cca     3048
 Gln Leu Pro Lys Val Cys Glu Met Lys Val Pro Asp Met Lys Leu Pro
         800                 805                 810

 gag ata aaa ctc ccc aag gtg cct gag atg gct gtg ccc gat gtg cac     3096
 Glu Ile Lys Leu Pro Lys Val Pro Glu Met Ala Val Pro Asp Val His
     815                 820                 825

 ctc ccc gag gtg cag ctg ccg aaa gtg tca gag att cgg ctg ccg gaa     3144
 Leu Pro Glu Val Gln Leu Pro Lys Val Ser Glu Ile Arg Leu Pro Glu
 830                 835                 840                 845

 atg caa gtg ccg aag gtt ccc gac gtg cat ctt ccg aag gca cca gag     3192
 Met Gln Val Pro Lys Val Pro Asp Val His Leu Pro Lys Ala Pro Glu
                 850                 855                 860

 gtg aag ctg ccc agg gct ccg gag gtg cag cta aag gcc acc aag gca     3240
 Val Lys Leu Pro Arg Ala Pro Glu Val Gln Leu Lys Ala Thr Lys Ala
             865                 870                 875

 gaa cag gca gaa ggg atg gaa ttt ggc ttc aag atg ccc aag atg acc     3288
 Glu Gln Ala Glu Gly Met Glu Phe Gly Phe Lys Met Pro Lys Met Thr
         880                 885                 890

 atg ccc aag cta ggg agg gca gag tcc cca tca cgt ggc aag cca ggc     3336
 Met Pro Lys Leu Gly Arg Ala Glu Ser Pro Ser Arg Gly Lys Pro Gly
     895                 900                 905

 gag gcg ggt gct gag gtc tca ggg aag ctg gta aca ctt ccc tgt ctg     3384
 Glu Ala Gly Ala Glu Val Ser Gly Lys Leu Val Thr Leu Pro Cys Leu
 910                 915                 920                 925

 cag cca gag gtg gat ggt gag gct cat gtg ggt gtc ccc tct ctc act     3432
 Gln Pro Glu Val Asp Gly Glu Ala His Val Gly Val Pro Ser Leu Thr
                 930                 935                 940

 ctg cct tca gtg gag cta gac ctg cca gga gca ctt ggc ctg cag ggg     3480
 Leu Pro Ser Val Glu Leu Asp Leu Pro Gly Ala Leu Gly Leu Gln Gly
             945                 950                 955

 cag gtc cca gcc gct aaa atg ggc aag gga gag cgg gtg gag ggc cct     3528
 Gln Val Pro Ala Ala Lys Met Gly Lys Gly Glu Arg Val Glu Gly Pro
         960                 965                 970

 gag gtg gca gca ggg gtc agg gaa gtg ggc ttc cga gtg ccc tct gtt     3576
 Glu Val Ala Ala Gly Val Arg Glu Val Gly Phe Arg Val Pro Ser Val
     975                 980                 985

 gaa att gtc acc cca cag ctg ccc gcc gtg gaa att gag gaa ggg cgg     3624
 Glu Ile Val Thr Pro Gln Leu Pro Ala Val Glu Ile Glu Glu Gly Arg
 990                 995                1000                1005

 ctg gag atg ata gag aca aaa gtc aag ccc tct tcc aag ttc tcc tta     3672
 Leu Glu Met Ile Glu Thr Lys Val Lys Pro Ser Ser Lys Phe Ser Leu
                1010                1015                1020

 cct aag ttt gga ctc tcg ggg cca aag gtg gct aag gca gag gct gag     3720
 Pro Lys Phe Gly Leu Ser Gly Pro Lys Val Ala Lys Ala Glu Ala Glu
            1025                1030                1035

 ggg gct ggg cga gct acc aag ctg aag gta tcc aaa ttt gcc atc tca     3768
 Gly Ala Gly Arg Ala Thr Lys Leu Lys Val Ser Lys Phe Ala Ile Ser
        1040                1045                1050

 ctc ccc aag gct cgg gtg ggg gct gag gct gag gcc aaa ggg gct ggg     3816
 Leu Pro Lys Ala Arg Val Gly Ala Glu Ala Glu Ala Lys Gly Ala Gly
    1055                1060                1065

 gag gca ggc ctg ctg cct gcc ctc gat ctg tcc atc cca cag ctc agc     3864
 Glu Ala Gly Leu Leu Pro Ala Leu Asp Leu Ser Ile Pro Gln Leu Ser
1070                1075                1080                1085

 ctg gat gcc cac ctg ccc tca ggc aag gta gag gtg gca ggg gcc gac     3912
 Leu Asp Ala His Leu Pro Ser Gly Lys Val Glu Val Ala Gly Ala Asp
                1090                1095                1100

 ctc aag ttc aag ggg ccc agg ttt gct ctc ccc aag ttt ggg gtc aga     3960
 Leu Lys Phe Lys Gly Pro Arg Phe Ala Leu Pro Lys Phe Gly Val Arg
            1105                1110                1115

 ggc cgg gac act gag gca gca gaa cta gtg cca ggg gtg gct gag ttg     4008
 Gly Arg Asp Thr Glu Ala Ala Glu Leu Val Pro Gly Val Ala Glu Leu
        1120                1125                1130

 gag ggc aag ggc tgg ggc tgg gat ggg agg gtg aag atg ccc aag ctg     4056
 Glu Gly Lys Gly Trp Gly Trp Asp Gly Arg Val Lys Met Pro Lys Leu
    1135                1140                1145

 aag atg cct tcc ttt ggg ctg gct cga ggg aag gaa gca gaa gtt caa     4104
 Lys Met Pro Ser Phe Gly Leu Ala Arg Gly Lys Glu Ala Glu Val Gln
1150                1155                1160                1165

 ggt gat cgt gcc agc ccg ggg gaa aag gct gag tcc acc gct gtg cag     4152
 Gly Asp Arg Ala Ser Pro Gly Glu Lys Ala Glu Ser Thr Ala Val Gln
                1170                1175                1180

 ctt aag atc ccc gag gtg gag ctg gtc acg ctg ggc gcc cag gag gaa     4200
 Leu Lys Ile Pro Glu Val Glu Leu Val Thr Leu Gly Ala Gln Glu Glu
            1185                1190                1195

 ggg agg gca gag ggg gct gtg gcc gtc agt gga atg cag ctg tca ggc     4248
 Gly Arg Ala Glu Gly Ala Val Ala Val Ser Gly Met Gln Leu Ser Gly
        1200                1205                1210

 ctg aag gtg tcc aca gcc ggg cag gtg gtc act gag ggc cat gac gcg     4296
 Leu Lys Val Ser Thr Ala Gly Gln Val Val Thr Glu Gly His Asp Ala
    1215                1220                1225

 ggg ctg agg atg cct ccg ctg ggc atc tcc ctg cca cag gtg gag ctg     4344
 Gly Leu Arg Met Pro Pro Leu Gly Ile Ser Leu Pro Gln Val Glu Leu
1230                1235                1240                1245

 acc ggc ttt ggg gag gca ggt acc cca ggg cag cag gct cag agt aca     4392
 Thr Gly Phe Gly Glu Ala Gly Thr Pro Gly Gln Gln Ala Gln Ser Thr
                1250                1255                1260

 gtc cct tca gca gag ggc aca gca ggc tac agg gtt cag gtg ccc cag     4440
 Val Pro Ser Ala Glu Gly Thr Ala Gly Tyr Arg Val Gln Val Pro Gln
            1265                1270                1275

 gtg acc ctg tct ctg cct gga gcc cag gtt gca ggt ggt gag ctg ctg     4488
 Val Thr Leu Ser Leu Pro Gly Ala Gln Val Ala Gly Gly Glu Leu Leu
        1280                1285                1290

 gtg ggt gag ggt gtc ttt aag atg ccc acc gtg aca gtg ccc cag ctt     4536
 Val Gly Glu Gly Val Phe Lys Met Pro Thr Val Thr Val Pro Gln Leu
    1295                1300                1305

 gag ctg gac gtg ggg cta agc cga gag gca cag gcg ggc gag gcg gcc     4584
 Glu Leu Asp Val Gly Leu Ser Arg Glu Ala Gln Ala Gly Glu Ala Ala
1310                1315                1320                1325

 aca ggc gag ggt ggg ctg agg ctg aag ttg ccc aca ctg ggg gcc aga     4632
 Thr Gly Glu Gly Gly Leu Arg Leu Lys Leu Pro Thr Leu Gly Ala Arg
                1330                1335                1340

 gct agg gtg ggg ggc gag ggt gct gag gag cag ccc cca ggg gcc gag     4680
 Ala Arg Val Gly Gly Glu Gly Ala Glu Glu Gln Pro Pro Gly Ala Glu
            1345                1350                1355

 cgt acc ttc tgc ctc tca ctg ccc gac gtg gag ctc tcg cca tcc ggg     4728
 Arg Thr Phe Cys Leu Ser Leu Pro Asp Val Glu Leu Ser Pro Ser Gly
        1360                1365                1370

 ggc aac cat gcc gag tac cag gtg gca gag ggg gag gga gag gcc gga     4776
 Gly Asn His Ala Glu Tyr Gln Val Ala Glu Gly Glu Gly Glu Ala Gly
    1375                1380                1385

 cac aag ctc aag gta cgg ctg ccc cgg ttt ggc ctg gtg cgg gcc aag     4824
 His Lys Leu Lys Val Arg Leu Pro Arg Phe Gly Leu Val Arg Ala Lys
1390                1395                1400                1405

 gag ggg gcc gag gag ggt gag aag gcc aag agc ccc aaa ctc agg ctg     4872
 Glu Gly Ala Glu Glu Gly Glu Lys Ala Lys Ser Pro Lys Leu Arg Leu
                1410                1415                1420

 ccc cga gtg ggc ttc agc caa agt gag atg gtc act ggg gaa ggg tcc     4920
 Pro Arg Val Gly Phe Ser Gln Ser Glu Met Val Thr Gly Glu Gly Ser
            1425                1430                1435

 ccc agc ccc gag gag gag gag gag gag gag gaa gag ggc agt ggg gaa     4968
 Pro Ser Pro Glu Glu Glu Glu Glu Glu Glu Glu Glu Gly Ser Gly Glu
        1440                1445                1450

 ggg gcc tcg ggt cgc cgg ggc cgg gtc cgg gtc cgc ttg cca cgt gta     5016
 Gly Ala Ser Gly Arg Arg Gly Arg Val Arg Val Arg Leu Pro Arg Val
    1455                1460                1465

 ggc ctg gcg gcc cct tct aaa gcc tct cgg ggg cag gag ggc gat gca     5064
 Gly Leu Ala Ala Pro Ser Lys Ala Ser Arg Gly Gln Glu Gly Asp Ala
1470                1475                1480                1485

 gcc ccc aag tcc ccc gtc aga gag aag tca ccc aag ttc cgc ttc ccc     5112
 Ala Pro Lys Ser Pro Val Arg Glu Lys Ser Pro Lys Phe Arg Phe Pro
                1490                1495                1500

 agg gtg tcc cta agc ccc aag gcc cgg agt ggg agt ggg gac cag gaa     5160
 Arg Val Ser Leu Ser Pro Lys Ala Arg Ser Gly Ser Gly Asp Gln Glu
            1505                1510                1515

 gag ggt gga ttg cgg gtg cgg ctg ccc agc gtg ggg ttt tca gag aca     5208
 Glu Gly Gly Leu Arg Val Arg Leu Pro Ser Val Gly Phe Ser Glu Thr
        1520                1525                1530

 ggg gct cca ggc ccg gcc agg atg gag ggg gct cag gct gcg gct gtc     5256
 Gly Ala Pro Gly Pro Ala Arg Met Glu Gly Ala Gln Ala Ala Ala Val
    1535                1540                1545

 tga agcc cctagtcaga tggggatccc ttcttgcctt cctttctcta ccccctcgct     5313
 


 gttgtgtgtg tgataactag cactaaccct aagagggccg ggaggtgggt gactgaccag   5373

 ggctggcagg gaggcctgct cctgtctctc tggcaggagt gcctgtaccc caccaagcca   5433

 tgtgaataaa ataatctgga agtaaaaaaa aaaaa                              5468




      <210> 70
      <211> 2958
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (242)..(2437)

      <400> 70
 ggcacgaggg catggcggag aaggatgaca ccggagtttg acgaaaaggt ggtttttgag     60

 aattctccac tttaccaata cttacaggat ctgggacaca cagactttga aatatgttct    120

 tctttgtcac caaaaacaga aaaatgcaca acagagggac aacaaaagcc tcctacaaga    180

 gtcctaccaa aatacctggg atatagtaat cactcaatga atataaactg cacttactgg    240

 c    atg ctc aag gaa tgg gct att aag caa ggt atc ctg tta aaa gtg     286
      Met Leu Lys Glu Trp Ala Ile Lys Gln Gly Ile Leu Leu Lys Val
        1               5                  10                  15

 gct gaa acc atc aaa agt tgg att ttt ttt tct cag tgc aat aag aaa      334
 Ala Glu Thr Ile Lys Ser Trp Ile Phe Phe Ser Gln Cys Asn Lys Lys
                  20                  25                  30

 gat gac tta ctt cac aag ttg gat att gga ttc cga ctc gac tca tta      382
 Asp Asp Leu Leu His Lys Leu Asp Ile Gly Phe Arg Leu Asp Ser Leu
              35                  40                  45

 cat acc atc ctg caa cag gaa gtc ctg tta caa gag gat gtg gag ctg      430
 His Thr Ile Leu Gln Gln Glu Val Leu Leu Gln Glu Asp Val Glu Leu
          50                  55                  60

 att gag cta ctt gat ccc agt atc ctg tct gca ggg caa tct caa caa      478
 Ile Glu Leu Leu Asp Pro Ser Ile Leu Ser Ala Gly Gln Ser Gln Gln
      65                  70                  75

 cag gaa aat gga cac ctt cca aca ctt tgc tcc ctg gca acc cct aat      526
 Gln Glu Asn Gly His Leu Pro Thr Leu Cys Ser Leu Ala Thr Pro Asn
  80                  85                  90                  95

 att tgg gat ctc tca atg cta ttt gcc ttc att agc ttg ctc gtt atg      574
 Ile Trp Asp Leu Ser Met Leu Phe Ala Phe Ile Ser Leu Leu Val Met
                 100                 105                 110

 ctt ccc act tgg tgg att gtg tct tcc tgg ctg gta tgg gga gtg att      622
 Leu Pro Thr Trp Trp Ile Val Ser Ser Trp Leu Val Trp Gly Val Ile
             115                 120                 125

 cta ttt gtg tat ctg gtc ata aga gct ttg aga tta tgg agg aca gcc      670
 Leu Phe Val Tyr Leu Val Ile Arg Ala Leu Arg Leu Trp Arg Thr Ala
         130                 135                 140

 aaa cta caa gtg acc cta aaa aaa tac agc gtt cat ttg gaa gat atg      718
 Lys Leu Gln Val Thr Leu Lys Lys Tyr Ser Val His Leu Glu Asp Met
     145                 150                 155

 gcc aca aac agc cga gct ttt act aac ctc gtg aga aaa gct tta cgt      766
 Ala Thr Asn Ser Arg Ala Phe Thr Asn Leu Val Arg Lys Ala Leu Arg
 160                 165                 170                 175

 ctc att caa gaa acc gaa gtg att tcc aga gga ttt aca ctg gtc agt      814
 Leu Ile Gln Glu Thr Glu Val Ile Ser Arg Gly Phe Thr Leu Val Ser
                 180                 185                 190

 gct gct tgc cca ttt aat aaa gct gga cag cat cca agt cag cat ctc      862
 Ala Ala Cys Pro Phe Asn Lys Ala Gly Gln His Pro Ser Gln His Leu
             195                 200                 205

 atc ggt ctt cgg aaa gct gtc tac cga act cta aga gcc aac ttc caa      910
 Ile Gly Leu Arg Lys Ala Val Tyr Arg Thr Leu Arg Ala Asn Phe Gln
         210                 215                 220

 gca gca agg cta gct acc cta tat atg ctg aaa aac tac ccc ctg aac      958
 Ala Ala Arg Leu Ala Thr Leu Tyr Met Leu Lys Asn Tyr Pro Leu Asn
     225                 230                 235

 tct gag agt gac aat gta acc aac tac atc tgt gtg gtg cct ttt aaa     1006
 Ser Glu Ser Asp Asn Val Thr Asn Tyr Ile Cys Val Val Pro Phe Lys
 240                 245                 250                 255

 gag ctg ggc ctt gga ctt agt gaa gag cag att tca gaa gag gaa gca     1054
 Glu Leu Gly Leu Gly Leu Ser Glu Glu Gln Ile Ser Glu Glu Glu Ala
                 260                 265                 270

 cat aac ttt aca gat ggc ttc agc ctg cct gca ttg aag gtt ttg ttc     1102
 His Asn Phe Thr Asp Gly Phe Ser Leu Pro Ala Leu Lys Val Leu Phe
             275                 280                 285

 caa ctc tgg gtg gca cag agt tca gag ttc ttc aga cgg tta gcc cta     1150
 Gln Leu Trp Val Ala Gln Ser Ser Glu Phe Phe Arg Arg Leu Ala Leu
         290                 295                 300

 tta ctt tct aca gcc aat tca cct cct ggg ccc tta ctt act cca gca     1198
 Leu Leu Ser Thr Ala Asn Ser Pro Pro Gly Pro Leu Leu Thr Pro Ala
     305                 310                 315

 ctt ctg cct cat cgt atc tta tct gat gtg act caa ggt cta cct cat     1246
 Leu Leu Pro His Arg Ile Leu Ser Asp Val Thr Gln Gly Leu Pro His
 320                 325                 330                 335

 gct cat tct gcc tgt ttg gaa gag ctt aag cgc agc tat gag ttc tat     1294
 Ala His Ser Ala Cys Leu Glu Glu Leu Lys Arg Ser Tyr Glu Phe Tyr
                 340                 345                 350

 cgg tac ttt gaa act cag cac cag tca gta ccg cag tgt tta tcc aaa     1342
 Arg Tyr Phe Glu Thr Gln His Gln Ser Val Pro Gln Cys Leu Ser Lys
             355                 360                 365

 act caa cag aag tca aga gaa ctg aat aat gtt cac aca gca gtg cgt     1390
 Thr Gln Gln Lys Ser Arg Glu Leu Asn Asn Val His Thr Ala Val Arg
         370                 375                 380

 agc ttg cag ctc cat ctg aaa gca tta ctg aat gag gta ata att ctt     1438
 Ser Leu Gln Leu His Leu Lys Ala Leu Leu Asn Glu Val Ile Ile Leu
     385                 390                 395

 gaa gat gaa ctt gaa aag ctt gtt tgt act aaa gaa aca caa gaa cta     1486
 Glu Asp Glu Leu Glu Lys Leu Val Cys Thr Lys Glu Thr Gln Glu Leu
 400                 405                 410                 415

 gtg tca gag gct tat ccc atc cta gaa cag aaa tta aag ttg att cag     1534
 Val Ser Glu Ala Tyr Pro Ile Leu Glu Gln Lys Leu Lys Leu Ile Gln
                 420                 425                 430

 ccc cac gtt caa gca agc aac aat tgc tgg gaa gag gcc att tct cag     1582
 Pro His Val Gln Ala Ser Asn Asn Cys Trp Glu Glu Ala Ile Ser Gln
             435                 440                 445

 gtc gac aaa ctg cta cga aga aat aca gat aaa aaa ggc aag cct gaa     1630
 Val Asp Lys Leu Leu Arg Arg Asn Thr Asp Lys Lys Gly Lys Pro Glu
         450                 455                 460

 ata gca tgt gaa aac cca cat tgt aca gta gta cct ttg aag cag cct     1678
 Ile Ala Cys Glu Asn Pro His Cys Thr Val Val Pro Leu Lys Gln Pro
     465                 470                 475

 act cta cac att gca gac aaa gat cca atc cca gag gag cag gaa tta     1726
 Thr Leu His Ile Ala Asp Lys Asp Pro Ile Pro Glu Glu Gln Glu Leu
 480                 485                 490                 495

 gaa gct tat gta gat gat ata gat att gat agt gat ttc aga aag gat     1774
 Glu Ala Tyr Val Asp Asp Ile Asp Ile Asp Ser Asp Phe Arg Lys Asp
                 500                 505                 510

 gat ttt tat tac ttg tct caa gaa gac aaa gag aga cag aag cgt gag     1822
 Asp Phe Tyr Tyr Leu Ser Gln Glu Asp Lys Glu Arg Gln Lys Arg Glu
             515                 520                 525

 cat gaa gaa tcc aag agg gtg ctc caa gaa tta aaa tct gtg ctg gga     1870
 His Glu Glu Ser Lys Arg Val Leu Gln Glu Leu Lys Ser Val Leu Gly
         530                 535                 540

 ttt aaa gct tca gag gca gaa agg cag aag tgg aag caa ctt cta ttt     1918
 Phe Lys Ala Ser Glu Ala Glu Arg Gln Lys Trp Lys Gln Leu Leu Phe
     545                 550                 555

 agt gat cat gcc gtg ttg aaa tcc ttg tct cct gta gac cca gtg gaa     1966
 Ser Asp His Ala Val Leu Lys Ser Leu Ser Pro Val Asp Pro Val Glu
 560                 565                 570                 575

 ccc ata agt aat tca gaa cca tca atg aat tca gat atg gga aaa gtc     2014
 Pro Ile Ser Asn Ser Glu Pro Ser Met Asn Ser Asp Met Gly Lys Val
                 580                 585                 590

 agt aaa aat gat act gaa gag gaa agt aat aaa tcc gcc aca aca gac     2062
 Ser Lys Asn Asp Thr Glu Glu Glu Ser Asn Lys Ser Ala Thr Thr Asp
             595                 600                 605

 aat gaa ata agt agg act gag tat tta tgt gaa aac tct cta gaa ggt     2110
 Asn Glu Ile Ser Arg Thr Glu Tyr Leu Cys Glu Asn Ser Leu Glu Gly
         610                 615                 620

 aaa aat aaa gat aat tct tca aat gaa gtc ttc ccc caa gga gca gaa     2158
 Lys Asn Lys Asp Asn Ser Ser Asn Glu Val Phe Pro Gln Gly Ala Glu
     625                 630                 635

 gaa aga atg tgt tac caa tgt gag agt gaa gat gaa cca caa gca gat     2206
 Glu Arg Met Cys Tyr Gln Cys Glu Ser Glu Asp Glu Pro Gln Ala Asp
 640                 645                 650                 655

 gga agt ggt ctg acc act gcc cct cca act ccc agg gac tca tta cag     2254
 Gly Ser Gly Leu Thr Thr Ala Pro Pro Thr Pro Arg Asp Ser Leu Gln
                 660                 665                 670

 ccc tcc att aag cag agg ctg gca cgg cta cag ctg tca cca gat ttt     2302
 Pro Ser Ile Lys Gln Arg Leu Ala Arg Leu Gln Leu Ser Pro Asp Phe
             675                 680                 685

 acc ttc act gct ggc ctt gct gca gaa gtg gct gct aga tct ctc tcc     2350
 Thr Phe Thr Ala Gly Leu Ala Ala Glu Val Ala Ala Arg Ser Leu Ser
         690                 695                 700

 ttt acc acc atg cag gaa cag act ttt ggt gat gag gag gaa gaa caa     2398
 Phe Thr Thr Met Gln Glu Gln Thr Phe Gly Asp Glu Glu Glu Glu Gln
     705                 710                 715

 ata ata gaa gaa aat aaa aat gag ata gaa gaa aag taa gaaccaagat      2447
 Ile Ile Glu Glu Asn Lys Asn Glu Ile Glu Glu Lys 
 720                 725                 730

 tcatatgaag tgatattaga ttgttccttt tacaaaagtg tttagcttca agactggaaa   2507

 gggaatatga gtgtaagttt actatatata aagctaagat gtggatttac aggaagaacc   2567

 ctggtttgaa taactgatct gaaattagta gttacctgta aatggcagat cttttaggaa   2627

 aataagagaa aggtaagggc tcttttgaat aaactgctgt tttatttgtg gcacaactga   2687

 tcaatcttgg aaattcttta agtattttta ataagaaatg aattatcatt tcttgccaga   2747

 atttgctacc ttaaggtgat tgggaaaatt ctgttgcaag aacattaaca tttagtatga   2807

 ctccttttta ctgtatttct tgcagtttaa ataactgcaa agctattatg tttaataaac   2867

 aagttggttt ggtattttta ttttttgttt tataccagtt cttaaacgat ccaggtttct   2927

 tgaataaaaa aattaatttt gatcccaaaa a                                  2958




      <210> 71
      <211> 2685
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2685)

      <400> 71
  atg ggg ggt gag ctc ttc aag ccc cag ggg aga att ctg ttc cgt tcc      48
  Met Gly Gly Glu Leu Phe Lys Pro Gln Gly Arg Ile Leu Phe Arg Ser
    1               5                  10                  15

 tgg gac atc cca ggt acc gtc aag cac aga aaa tac ttg tgg cat gaa       96
 Trp Asp Ile Pro Gly Thr Val Lys His Arg Lys Tyr Leu Trp His Glu
              20                  25                  30

 tgt gat gag aac aca gaa ttg cag aag cca aag aaa gag aag cgt aag      144
 Cys Asp Glu Asn Thr Glu Leu Gln Lys Pro Lys Lys Glu Lys Arg Lys
          35                  40                  45

 ggc cct cct tcc acc cct acc tcc ccc acc cgc tgc tac acg cac cag      192
 Gly Pro Pro Ser Thr Pro Thr Ser Pro Thr Arg Cys Tyr Thr His Gln
      50                  55                  60

 gac cac ctg ctg gag ccc ctc gtg tcc tcc ctt gca gca cgc atg gga      240
 Asp His Leu Leu Glu Pro Leu Val Ser Ser Leu Ala Ala Arg Met Gly
  65                  70                  75                  80

 aga aag gcc atc gtc ctc gcc att gct aac acc agc ctt gcg ttt cct      288
 Arg Lys Ala Ile Val Leu Ala Ile Ala Asn Thr Ser Leu Ala Phe Pro
                  85                  90                  95

 ctt tgc cag aat agg ggg gtc att gag gga aat ttc caa agg aag gtg      336
 Leu Cys Gln Asn Arg Gly Val Ile Glu Gly Asn Phe Gln Arg Lys Val
             100                 105                 110

 gaa cgg gat ggg tgg gga ggt aag ggc atg agc aga ggc agt gat cgt      384
 Glu Arg Asp Gly Trp Gly Gly Lys Gly Met Ser Arg Gly Ser Asp Arg
         115                 120                 125

 ggg cag gag gtg tcc ata gaa gac ggg ctg cca ctg gcc ctg gag aca      432
 Gly Gln Glu Val Ser Ile Glu Asp Gly Leu Pro Leu Ala Leu Glu Thr
     130                 135                 140

 gaa gag cag agg aag cgt tac tcc aca gtt gtt atg gct gat gta tcc      480
 Glu Glu Gln Arg Lys Arg Tyr Ser Thr Val Val Met Ala Asp Val Ser
 145                 150                 155                 160

 cag tac cca gtc aat cac ctg gtg acg ttc tgc ctg ggt gag gac gat      528
 Gln Tyr Pro Val Asn His Leu Val Thr Phe Cys Leu Gly Glu Asp Asp
                 165                 170                 175

 ggc gtg cat acc gtg gag gat gcc tcc agg aag ttg gcc gtc atg gat      576
 Gly Val His Thr Val Glu Asp Ala Ser Arg Lys Leu Ala Val Met Asp
             180                 185                 190

 agc cag ggc cga gtc tgg gca cag gag atg ctg ctg cga gtg tct ccc      624
 Ser Gln Gly Arg Val Trp Ala Gln Glu Met Leu Leu Arg Val Ser Pro
         195                 200                 205

 gac cat gtc acg ctg ctc gac ccg gcc tcc aag gtg ccg ggg ggc acg      672
 Asp His Val Thr Leu Leu Asp Pro Ala Ser Lys Val Pro Gly Gly Thr
     210                 215                 220

 agc cgc tcg ttg ctg ctg ctc gtg tgc cag gaa ccc gag cgc gcg cag      720
 Ser Arg Ser Leu Leu Leu Leu Val Cys Gln Glu Pro Glu Arg Ala Gln
 225                 230                 235                 240

 ccc gac gtg cac ttc ttc cag ggc ctg cgc ctc ggg gcg gag ctg atc      768
 Pro Asp Val His Phe Phe Gln Gly Leu Arg Leu Gly Ala Glu Leu Ile
                 245                 250                 255

 cga gag gac atc cag ggg gct ctg cac aat tac cgc tcg ggc cgc ggg      816
 Arg Glu Asp Ile Gln Gly Ala Leu His Asn Tyr Arg Ser Gly Arg Gly
             260                 265                 270

 gag cgc agg gcg gcg gcg ctc agg gcc acg cag gag gag ttg cag cgc      864
 Glu Arg Arg Ala Ala Ala Leu Arg Ala Thr Gln Glu Glu Leu Gln Arg
         275                 280                 285

 gac cgc tcg ccc gcc gct gag acc ccg ccc ctg cag cgc cgc ccg tca      912
 Asp Arg Ser Pro Ala Ala Glu Thr Pro Pro Leu Gln Arg Arg Pro Ser
     290                 295                 300

 gtc cgc gca gtg atc agc acc gta gag cgg ggc gcg ggc cgc gga cga      960
 Val Arg Ala Val Ile Ser Thr Val Glu Arg Gly Ala Gly Arg Gly Arg
 305                 310                 315                 320

 ccc cag gcg aag ccc att ccc gag gca gag gag gcg cag agg cct gag     1008
 Pro Gln Ala Lys Pro Ile Pro Glu Ala Glu Glu Ala Gln Arg Pro Glu
                 325                 330                 335

 ccg gtg ggg acc tcg agc aac gct gac tcg gcc tcc ccg gac ctg ggt     1056
 Pro Val Gly Thr Ser Ser Asn Ala Asp Ser Ala Ser Pro Asp Leu Gly
             340                 345                 350

 ccc cgg ggt cct gac ctg gcg gtt ctg cag gcg gag cgg gaa gtg gac     1104
 Pro Arg Gly Pro Asp Leu Ala Val Leu Gln Ala Glu Arg Glu Val Asp
         355                 360                 365

 atc ctg aac cac gtg ttc gac gac gta gag agc ttt gta tcg agg ctg     1152
 Ile Leu Asn His Val Phe Asp Asp Val Glu Ser Phe Val Ser Arg Leu
     370                 375                 380

 cag aag tcg gcg gag gcg gcc agg gtg ctg gag cac gcg gaa cgc ggc     1200
 Gln Lys Ser Ala Glu Ala Ala Arg Val Leu Glu His Ala Glu Arg Gly
 385                 390                 395                 400

 cgc agg agc cgg cgc cgg gcg gct ggg gag ggc ttg ctg acg ctg cgg     1248
 Arg Arg Ser Arg Arg Arg Ala Ala Gly Glu Gly Leu Leu Thr Leu Arg
                 405                 410                 415

 gcc aag ccg ccc tcg gag gcc gag tac acc gac gtg ctg cag aag atc     1296
 Ala Lys Pro Pro Ser Glu Ala Glu Tyr Thr Asp Val Leu Gln Lys Ile
             420                 425                 430

 aag tac gcc ttc agc ctg ctg gcc cgg ctg cgc ggc aac atc gcc gac     1344
 Lys Tyr Ala Phe Ser Leu Leu Ala Arg Leu Arg Gly Asn Ile Ala Asp
         435                 440                 445

 ccc tcc tct ctg gag ctg ttg cac ttc ctt ttc ggg cct ctg cag atg     1392
 Pro Ser Ser Leu Glu Leu Leu His Phe Leu Phe Gly Pro Leu Gln Met
     450                 455                 460

 att gtg aac acg tcg ggg ggg ccg gag ttc gcg agc agt gtg cgg cgg     1440
 Ile Val Asn Thr Ser Gly Gly Pro Glu Phe Ala Ser Ser Val Arg Arg
 465                 470                 475                 480

 ccg cat ctg aca tcg gat gcc gtg gcg ctg ctg cgg gac aac gtc act     1488
 Pro His Leu Thr Ser Asp Ala Val Ala Leu Leu Arg Asp Asn Val Thr
                 485                 490                 495

 cca cgt gaa aac gag ctc tgg acc tcg ctg ggg gac tcg tgg acc cgc     1536
 Pro Arg Glu Asn Glu Leu Trp Thr Ser Leu Gly Asp Ser Trp Thr Arg
             500                 505                 510

 ccc ggg ctg gag ctg tcc ccg gag gag gga ccc cca tac aga ccc gag     1584
 Pro Gly Leu Glu Leu Ser Pro Glu Glu Gly Pro Pro Tyr Arg Pro Glu
         515                 520                 525

 ttc ttc agc ggc tgg gag ccg ccg gtc act gac ccg cag agc cgc gcc     1632
 Phe Phe Ser Gly Trp Glu Pro Pro Val Thr Asp Pro Gln Ser Arg Ala
     530                 535                 540

 tgg gag gac cca gtt gag aaa cag cta cag cac gag cgg agg cgc cgg     1680
 Trp Glu Asp Pro Val Glu Lys Gln Leu Gln His Glu Arg Arg Arg Arg
 545                 550                 555                 560

 cag caa agc gcc ccc gag gtc gct gtc aat ggt cac cga gac ttg gag     1728
 Gln Gln Ser Ala Pro Glu Val Ala Val Asn Gly His Arg Asp Leu Glu
                 565                 570                 575

 cca gaa tct gag cct cag ctg gag tca gag aca gca gga aaa tgg gtc     1776
 Pro Glu Ser Glu Pro Gln Leu Glu Ser Glu Thr Ala Gly Lys Trp Val
             580                 585                 590

 ctg tgt aat tat gac ttc cag gcc cgc aac agc agt gag ctg tcg gtc     1824
 Leu Cys Asn Tyr Asp Phe Gln Ala Arg Asn Ser Ser Glu Leu Ser Val
         595                 600                 605

 aag cag cgg gac gta ctg gag gtc ctg gat gac agt cgt aag tgg tgg     1872
 Lys Gln Arg Asp Val Leu Glu Val Leu Asp Asp Ser Arg Lys Trp Trp
     610                 615                 620

 aag gtt cgg gac cca gcg ggg cag gag gga tat gtg ccc tac aac atc     1920
 Lys Val Arg Asp Pro Ala Gly Gln Glu Gly Tyr Val Pro Tyr Asn Ile
 625                 630                 635                 640

 ctg aca ccc tac ccc gga ccc cgg ctg cac cac agc caa agc cct gcc     1968
 Leu Thr Pro Tyr Pro Gly Pro Arg Leu His His Ser Gln Ser Pro Ala
                 645                 650                 655

 cgc agc ctg aac agc act cct cct cca cca cca gcc cca gcc ccg gcc     2016
 Arg Ser Leu Asn Ser Thr Pro Pro Pro Pro Pro Ala Pro Ala Pro Ala
             660                 665                 670

 cca cct cca gct ctg gct cgg ccc cgc tgg gac agg ccc cgc tgg gac     2064
 Pro Pro Pro Ala Leu Ala Arg Pro Arg Trp Asp Arg Pro Arg Trp Asp
         675                 680                 685

 agc tgc gat agc tca acg gct tgg acc cca gcg aga agg gtg agt gag     2112
 Ser Cys Asp Ser Ser Thr Ala Trp Thr Pro Ala Arg Arg Val Ser Glu
     690                 695                 700

 aaa ttc tcc cag atg ctc atc gtc aac gag gaa ctg cag gcg cgc ctg     2160
 Lys Phe Ser Gln Met Leu Ile Val Asn Glu Glu Leu Gln Ala Arg Leu
 705                 710                 715                 720

 gcc cag ggc cgc tcg gga ccg agc cgc gca gtc cca ggg ccc cgc gcc     2208
 Ala Gln Gly Arg Ser Gly Pro Ser Arg Ala Val Pro Gly Pro Arg Ala
                 725                 730                 735

 ccg gaa ccg cag ctc agc ccg ggc tcg gac gcc tcc gag gtc cgc gcc     2256
 Pro Glu Pro Gln Leu Ser Pro Gly Ser Asp Ala Ser Glu Val Arg Ala
             740                 745                 750

 tgg ctg cag gcc aag ggc ttt agc tcc ggg acc gtg gac gcg ctg ggt     2304
 Trp Leu Gln Ala Lys Gly Phe Ser Ser Gly Thr Val Asp Ala Leu Gly
         755                 760                 765

 gtg ctg acc ggg gcg cag ctt ttc tcg ctg cag agg gag gag ctg cgg     2352
 Val Leu Thr Gly Ala Gln Leu Phe Ser Leu Gln Arg Glu Glu Leu Arg
     770                 775                 780

 gcg gtg agc ccc gag gag ggg gca cgt gtg tac agc cag gtc acc gtg     2400
 Ala Val Ser Pro Glu Glu Gly Ala Arg Val Tyr Ser Gln Val Thr Val
 785                 790                 795                 800

 cag cgc tcg ctg ctg gag cat ctt gga tct gct ctc ctc agc aat cag     2448
 Gln Arg Ser Leu Leu Glu His Leu Gly Ser Ala Leu Leu Ser Asn Gln
                 805                 810                 815

 aag ctt gaa act ctg gac ctg ggc cag aat cat ttg tgg aag agt ggc     2496
 Lys Leu Glu Thr Leu Asp Leu Gly Gln Asn His Leu Trp Lys Ser Gly
             820                 825                 830

 ata att aag ctc ttt ggg gtt cta aga caa aga act gga tcc ttg aag     2544
 Ile Ile Lys Leu Phe Gly Val Leu Arg Gln Arg Thr Gly Ser Leu Lys
         835                 840                 845

 ata ctc agg ttg aag acc tat gaa act aat ttg gaa atc aag aag ctg     2592
 Ile Leu Arg Leu Lys Thr Tyr Glu Thr Asn Leu Glu Ile Lys Lys Leu
     850                 855                 860

 ttg gag gaa gtg aaa gaa aag aat ccc aag ctg act att gat tgc aat     2640
 Leu Glu Glu Val Lys Glu Lys Asn Pro Lys Leu Thr Ile Asp Cys Asn
 865                 870                 875                 880

 gct tcc ggg gca acg gca cct ccg tgc tgt gac ttt ttt tgc tga         2685
 Ala Ser Gly Ala Thr Ala Pro Pro Cys Cys Asp Phe Phe Cys 
                 885                 890





      <210> 72
      <211> 623
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (168)..(332)

      <400> 72
 ctcaccgtgt gtagttggca tctccgcgcg tccggacacc cgatcccagc atccctgcct     60

 gcaggactgt tcgtgttcag ctcgcgtcct gcagctgtcc gaggtgctcc agttggaggc    120

 tgaggttccc gggctctgta gctgagtggg cggcggcacc ggcggag  atg cct ggg     176
                                                      Met Pro Gly
                                                        1

 aag aag gcg cgc aag aac gct caa ccg agc ccc gcg cgg gct cca gca      224
 Lys Lys Ala Arg Lys Asn Ala Gln Pro Ser Pro Ala Arg Ala Pro Ala
       5                  10                  15

 gag ctg gaa gtc gag tgt gct act caa ctc agg aga ttt gga gac aaa      272
 Glu Leu Glu Val Glu Cys Ala Thr Gln Leu Arg Arg Phe Gly Asp Lys
  20                  25                  30                  35

 ctg aac ttc cgg cag aaa ctt ctg aat ctg ata tcc aaa ctc ttc tgc      320
 Leu Asn Phe Arg Gln Lys Leu Leu Asn Leu Ile Ser Lys Leu Phe Cys
                  40                  45                  50

 tca gga acc tga ctg catcaaaaac ttgcatgagg ggactccttc aaaagagttt      375
 Ser Gly Thr 


 tctcaggagg tgcacgtttc atcaatttga agaaagactg cattgtaatt gagaggaatg    435

 tgaaggtgca ttcatgggtg cccttggaaa cggaagatgg aatacatcaa agtgaatttc    495

 tgttcaagtt ttcccagatt atcattcttt gggatgagag aacattataa aaccactttg    555

 tttattttaa agcaagaatg gaagaccctt gaaaataaag aagtaattat tgacacaaaa    615

 aaaaaaaa                                                             623




      <210> 73
      <211> 2760
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (241)..(1251)

      <400> 73
 gcaggggagg tggctggttt aaggggaact tgagggaagt agggaagact cctctcggga     60

 cctttggagt aggtgacaca tgagcccagc cccagctcac ctgccaatcc agctgaggag    120

 ctcacctgcc aatccagctg aggctgggca gaggtgggtg agaagaggga aaattgcagg    180

 gacctccagt tgggccaggc cagaagctgc tgtagcttta accagacagc tcagacctgt    240
                                                                 
 atg gag gct gcc agt gac agg tta ggt tta ggg cag aga aga agc aag      288
 Met Glu Ala Ala Ser Asp Arg Leu Gly Leu Gly Gln Arg Arg Ser Lys
   1               5                  10                  15

 acc atg gtg ggg aag atg tgg cct gtg ttg tgg aca ctc tgt gca gtc      336
 Thr Met Val Gly Lys Met Trp Pro Val Leu Trp Thr Leu Cys Ala Val
              20                  25                  30

 agg gtg acc gtc gat gcc atc tct gtg gaa act ccg cag gac gtt ctt      384
 Arg Val Thr Val Asp Ala Ile Ser Val Glu Thr Pro Gln Asp Val Leu
          35                  40                  45

 cgg gct tcg cag gga aag agt gtc acc ctg ccc tgc acc tac cac act      432
 Arg Ala Ser Gln Gly Lys Ser Val Thr Leu Pro Cys Thr Tyr His Thr
      50                  55                  60

 tcc acc tcc agt cga gag gga ctt att caa tgg gat aag ctc ctc ctc      480
 Ser Thr Ser Ser Arg Glu Gly Leu Ile Gln Trp Asp Lys Leu Leu Leu
  65                  70                  75                  80

 act cat acg gaa agg gtg gtc atc tgg ccg ttt tca aac aaa aac tac      528
 Thr His Thr Glu Arg Val Val Ile Trp Pro Phe Ser Asn Lys Asn Tyr
                  85                  90                  95

 atc cat ggt gag ctt tat aag aat cgc gtc agc ata tcc aac aat gct      576
 Ile His Gly Glu Leu Tyr Lys Asn Arg Val Ser Ile Ser Asn Asn Ala
             100                 105                 110

 gag cag tcc gat gcc tcc atc acc att gat cag ctg acc atg gct gac      624
 Glu Gln Ser Asp Ala Ser Ile Thr Ile Asp Gln Leu Thr Met Ala Asp
         115                 120                 125

 aac ggc acc tac gag tgt tct gtc tcg ctg atg tca gac ctg gag ggc      672
 Asn Gly Thr Tyr Glu Cys Ser Val Ser Leu Met Ser Asp Leu Glu Gly
     130                 135                 140

 aac acc aag tca cgt gtc cgc ctg ttg gtc ctc gtg cca ccc tcc aaa      720
 Asn Thr Lys Ser Arg Val Arg Leu Leu Val Leu Val Pro Pro Ser Lys
 145                 150                 155                 160

 cca gaa tgc ggc atc gag gga gag acc ata att ggg aac aac atc cag      768
 Pro Glu Cys Gly Ile Glu Gly Glu Thr Ile Ile Gly Asn Asn Ile Gln
                 165                 170                 175

 ctg acc tgc caa tca aag gag ggc tca cca acc cct cag tac agc tgg      816
 Leu Thr Cys Gln Ser Lys Glu Gly Ser Pro Thr Pro Gln Tyr Ser Trp
             180                 185                 190

 aag agg tac aac atc ctg aat cag gag cag ccc ctg gcc cag cca gcc      864
 Lys Arg Tyr Asn Ile Leu Asn Gln Glu Gln Pro Leu Ala Gln Pro Ala
         195                 200                 205

 tca ggt cag cct gtc tcc ctg aag aat atc tcc aca gac aca tcg ggt      912
 Ser Gly Gln Pro Val Ser Leu Lys Asn Ile Ser Thr Asp Thr Ser Gly
     210                 215                 220

 tac tac atc tgt acc tcc agc aat gag gag ggg acg cag ttc tgc aac      960
 Tyr Tyr Ile Cys Thr Ser Ser Asn Glu Glu Gly Thr Gln Phe Cys Asn
 225                 230                 235                 240

 atc acg gtg gcc gtc aga tct ccc tcc atg aac gtg gcc ctg tat gtg     1008
 Ile Thr Val Ala Val Arg Ser Pro Ser Met Asn Val Ala Leu Tyr Val
                 245                 250                 255

 ggc atc gcg gtg ggc gtg gtt gca gcc ctc att atc att ggc atc atc     1056
 Gly Ile Ala Val Gly Val Val Ala Ala Leu Ile Ile Ile Gly Ile Ile
             260                 265                 270

 atc tac tgc tgc tgc tgc cga ggg aag gac gac aac act gaa gac aag     1104
 Ile Tyr Cys Cys Cys Cys Arg Gly Lys Asp Asp Asn Thr Glu Asp Lys
         275                 280                 285

 gag gat gca agg ccg aac cgg gaa gcc tat gag gag cca cca gag cag     1152
 Glu Asp Ala Arg Pro Asn Arg Glu Ala Tyr Glu Glu Pro Pro Glu Gln
     290                 295                 300

 cta aga gaa ctt tcc aga gag agg gag gag gag gat gac tac agg caa     1200
 Leu Arg Glu Leu Ser Arg Glu Arg Glu Glu Glu Asp Asp Tyr Arg Gln
 305                 310                 315                 320

 gaa gag cag agg agc act ggg cgt gaa tcc ccg gac cac ctc gac cag     1248
 Glu Glu Gln Arg Ser Thr Gly Arg Glu Ser Pro Asp His Leu Asp Gln
                 325                 330                 335

 tga cagg ccagcagcag agggcggcgg aggaagggtt aggggttcat tctcccgctt     1305
 


 cctggcctcc cttctccttt ctaagccctg ttctcctgtc cctccatccc agacattgat   1365

 ggggacattt cttccccagt gtcagctgtg gggaacatgg ctggcctggt aagggggtcc   1425

 ctgtgctgat cctgctgacc tcactgtcct gtgaagtaac ccctcctggc tgtgacacct   1485

 ggtgcgggcc tggccctcac tcaagaccag gctgcagcct ccacttccct cgtagttggc   1545

 aggagctcct ggaagcacag cgctgagcat ggggcgctcc cactcagaac tctccaggga   1605

 ggcgatgcca gccttggggg gtgggggctg tcctgctcac ctgtgtgccc agcacctgga   1665

 ggggcaccag gtggagggtt tgcactccac acatctttct tgaatgaatg aaagaataag   1725

 tgagtatgct tgggccctgc attggcctgg cctccagctc ccactccctt tccaacctca   1785

 cttcccgtag ctgccagtat gttccaaacc ctcctgggaa ggccacctcc cactcctgct   1845

 gcacaggccc tggggagctt ttgcccacac actttccatc tctgcctgtc aatatcgtac   1905

 ctgtccctcc aggcccatct caaatcacaa ggatttctct aaccctatcc taattgtcca   1965

 catacgtgga aacaatcctg ttactctgtc ccacgtccaa tcatgggcca caaggcacag   2025

 tcttctgagc gagtgctctc actgtattag agcgccagct ccttggggca gggcctgggc   2085

 ctcatggctt ttgctttccc tgaagcccta gtagctggcg cccatcctag tgggcactta   2145

 agcttaattg gggaaactgc tttgattggt tgtgccttcc cttctctggt ctccttgaga   2205

 tgatcgtaga cacagggatg attcccaccc aaacccacgt attcattcag tgagttaaac   2265

 acgaattgat ttaaagtgaa cacacacaag ggagcttgct tgcagatggt ctgagttctt   2325

 gtgtcctggt aattcctctc caggccagaa taattggcat gtctcctcaa cccacatggg   2385

 gttcctggtt gttcctgcat cccgatacct cagccctggc cctgcccagc ccatttgggc   2445

 tctggttttc tggtggggct gtcctgctgc cctcccacag cctccttctg tttgtcgagc   2505

 atttcttcta ctcttgagag ctcaggcagc gttagggctg cttaggtctc atggaccagt   2565

 ggctggtctc acccaactgc agtttactat tgctatcttt tctggatgat cagaaaaata   2625

 attccataaa tctattgtct acttgcgatt ttttaaaaaa tgtatatttt tatatatatt   2685

 gttaaatcct ttgcttcatt ccaaatgctt tcagtaataa taaaattgtg ggtggaaatt   2745

 cttaaaaaaa aaaaa                                                    2760




      <210> 74
      <211> 1054
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (81)..(719)

      <220>
      <221> misc_feature
      <222> (1)...(1054)
      <223> n = a,t,c or g

      <400> 74
 gccctgtccg gaattcccgt gtcgactatt tcgttgagcc cgctgcccgc ccgcagttcc     60

 cggccccgct ggccccagtc    atg gcg aag cag tac gat gtg ctg ttc cgg     110
                          Met Ala Lys Gln Tyr Asp Val Leu Phe Arg
                            1               5                  10

 ctg ctg ctg atc ggg gac tcc ggg gtg ggc aag acc tgc ctg ctg tgc      158
 Leu Leu Leu Ile Gly Asp Ser Gly Val Gly Lys Thr Cys Leu Leu Cys
                  15                  20                  25

 cgc ttc acc gac aac gag ttc cac tcc tcg cac atc tcc acc atc ggt      206
 Arg Phe Thr Asp Asn Glu Phe His Ser Ser His Ile Ser Thr Ile Gly
              30                  35                  40

 gtt gac ttt aag atg aag acc ata gag gta gac ggc atc aaa gtg cgg      254
 Val Asp Phe Lys Met Lys Thr Ile Glu Val Asp Gly Ile Lys Val Arg
          45                  50                  55

 ata cag atc tgg gac act gca ggg cag gag aga tac cag acc atc aca      302
 Ile Gln Ile Trp Asp Thr Ala Gly Gln Glu Arg Tyr Gln Thr Ile Thr
      60                  65                  70

 aag cag tac tat cgg cgg gcc cag ggg ata ttt ttg gtc tat gac att      350
 Lys Gln Tyr Tyr Arg Arg Ala Gln Gly Ile Phe Leu Val Tyr Asp Ile
  75                  80                  85                  90

 agc agc gag cgc tct tac cag cac atc atg aag tgg gtc agt gac gtg      398
 Ser Ser Glu Arg Ser Tyr Gln His Ile Met Lys Trp Val Ser Asp Val
                  95                 100                 105

 gat gag tac gca cca gaa ggc gtc cag aag atc ctt att ggg aat aag      446
 Asp Glu Tyr Ala Pro Glu Gly Val Gln Lys Ile Leu Ile Gly Asn Lys
             110                 115                 120

 gct gat gag gag cag aaa cgg cag gtg gga aga gag caa ggg cag cag      494
 Ala Asp Glu Glu Gln Lys Arg Gln Val Gly Arg Glu Gln Gly Gln Gln
         125                 130                 135

 ctg gcg aag gag tat ggc atg gac ttc tat gaa aca agt gcc tgc acc      542
 Leu Ala Lys Glu Tyr Gly Met Asp Phe Tyr Glu Thr Ser Ala Cys Thr
     140                 145                 150

 aac ctc aac att aaa gag tca ttc acg cgt ctg aca gag ctg gtg ctg      590
 Asn Leu Asn Ile Lys Glu Ser Phe Thr Arg Leu Thr Glu Leu Val Leu
 155                 160                 165                 170

 cag gcc cat agg aag gag ctg gaa ggc ctc cgg atg cgt gcc agc aat      638
 Gln Ala His Arg Lys Glu Leu Glu Gly Leu Arg Met Arg Ala Ser Asn
                 175                 180                 185

 gag ttg gca ctg gca gag ctg gag gag gag gag ggc aaa ccc gag ggc      686
 Glu Leu Ala Leu Ala Glu Leu Glu Glu Glu Glu Gly Lys Pro Glu Gly
             190                 195                 200

 cca gcg aac tct tcg aaa acc tgc tgg tgc tga gtcctgtn tggggcaccc      737
 Pro Ala Asn Ser Ser Lys Thr Cys Trp Cys 
         205                 210

 cacacgacac ccctcttccc tcaggaggcc cgtgggcaga caggggagcc ggggctttgc    797

 cctgctgctg tcctctcatg tgatgaccct attgagtatc agtagccact actccccctg    857

 cctggccctg agagcggctc tgctgtcatc tcaagcagcc cctgtcccca gcccgtccac    917

 cctggagtgg tcttcttcag cctgtttccc cgaccacagg cctgctacga cccccacgat    977

 gtgccgcaag cactgtctca ccatcccgca cccaccagac aacagccagg gctggagtcc   1037

 aggccaaaaa aaaaaaa                                                  1054




      <210> 75
      <211> 3962
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (652)..(3900)

      <400> 75
 ggagaaaatt tacagaaacc cagagccaaa ggtgctctca ggggatcccc tgaaacattc     60

 aaagccattg cggccccaga agcttgggta ggcggggaag cagctggagt gcgaccgccg    120

 cggcagccac cctgcaaccg ccagtcggag gtgcagtccg taggccctgg cccccgggtg    180

 ggcccttggg gagtcggcgc cgctcccggg gagctgcaag gctcgcccct gcccggcgtg    240

 gagggcgcgg ggggcgcgga ggatattctt ggtgatcttg gaagtgtccg tatcatggaa    300

 tcaatctcta tgatgggaag ccctaagagc cttagtgaaa cttttttacc taatggcata    360

 aatggtatca aagatgcaag gaaggtcact gtaggtgtga ttggaagtgg agattttgcc    420

 aaatccttga ccattcgact tattagatgc ggctatcatg tggtcatagg aagtagaaat    480

 cctaagtttg cttctgaatt ttttcctcat gtggtagatg tcactcatca tgaagatgct    540

 ctcacaaaaa caaatataat atttgttgct atacacagag aacattatac ctccctgtgg    600

 gacctgagac atctgcttgt gggtaaaatc ctgattgatg tgagcaataa c atg agg     657
                                                          Met Arg
                                                            1

 ata aac cag tac cca gaa tcc aat gct gaa tat ttg gct tca tta ttc      705
 Ile Asn Gln Tyr Pro Glu Ser Asn Ala Glu Tyr Leu Ala Ser Leu Phe
           5                  10                  15

 cca gat tct ttg att gtc aaa gga ttt aat gtt gtc tca gct tgg gca      753
 Pro Asp Ser Leu Ile Val Lys Gly Phe Asn Val Val Ser Ala Trp Ala
      20                  25                  30

 ctt cag tta gga cct aag gat gcc agc cgg cag gtt tat ata tgc agc      801
 Leu Gln Leu Gly Pro Lys Asp Ala Ser Arg Gln Val Tyr Ile Cys Ser
  35                  40                  45                  50

 aac aat att caa gcg cga caa cag gtt att gaa ctt gcc cgc cag ttg      849
 Asn Asn Ile Gln Ala Arg Gln Gln Val Ile Glu Leu Ala Arg Gln Leu
                  55                  60                  65

 aat ttc att ccc att gac ttg gga tcc tta tca tca gcc aga gag att      897
 Asn Phe Ile Pro Ile Asp Leu Gly Ser Leu Ser Ser Ala Arg Glu Ile
              70                  75                  80

 gaa aat tta ccc cta cga ctc ttt act ctc tgg aga ggg cca gtg gtg      945
 Glu Asn Leu Pro Leu Arg Leu Phe Thr Leu Trp Arg Gly Pro Val Val
          85                  90                  95

 gta gct ata agc ttg gcc aca ttt ttt ttc ctt tat tcc ttt gtc aga      993
 Val Ala Ile Ser Leu Ala Thr Phe Phe Phe Leu Tyr Ser Phe Val Arg
     100                 105                 110

 gat gtg att cat cca tat gct aga aac caa cag agt gac ttt tac aaa     1041
 Asp Val Ile His Pro Tyr Ala Arg Asn Gln Gln Ser Asp Phe Tyr Lys
 115                 120                 125                 130

 att cct ata gag att gtg aat aaa acc tta cct ata gtt gcc att act     1089
 Ile Pro Ile Glu Ile Val Asn Lys Thr Leu Pro Ile Val Ala Ile Thr
                 135                 140                 145

 ttg ctc tcc cta gta tac ctt gca ggt ctt ctg gca gct gct tat caa     1137
 Leu Leu Ser Leu Val Tyr Leu Ala Gly Leu Leu Ala Ala Ala Tyr Gln
             150                 155                 160

 ctt tat tac ggc acc aag tat agg aga ttt cca cct tgg ttg gaa acc     1185
 Leu Tyr Tyr Gly Thr Lys Tyr Arg Arg Phe Pro Pro Trp Leu Glu Thr
         165                 170                 175

 tgg tta cag tgt aga aaa cag ctt gga tta cta agt ttt ttc ttc gct     1233
 Trp Leu Gln Cys Arg Lys Gln Leu Gly Leu Leu Ser Phe Phe Phe Ala
     180                 185                 190

 atg gtc cat gtt gcc tac agc ctc tgc tta ccg atg aga agg tca gag     1281
 Met Val His Val Ala Tyr Ser Leu Cys Leu Pro Met Arg Arg Ser Glu
 195                 200                 205                 210

 aga tat ttg ttt ctc aac atg gct tat cag cag tct aca ctt gga tat     1329
 Arg Tyr Leu Phe Leu Asn Met Ala Tyr Gln Gln Ser Thr Leu Gly Tyr
                 215                 220                 225

 gtc gct ctg ctc ata agt act ttc cat gtt tta att tat gga tgg aaa     1377
 Val Ala Leu Leu Ile Ser Thr Phe His Val Leu Ile Tyr Gly Trp Lys
             230                 235                 240

 cga gct ttt gag gaa gag tac tac aga ttt tat aca cca cca aac ttt     1425
 Arg Ala Phe Glu Glu Glu Tyr Tyr Arg Phe Tyr Thr Pro Pro Asn Phe
         245                 250                 255

 gtt ctt gct ctt gtt ttg ccc tca att gta att ctg gat ctg tct gtg     1473
 Val Leu Ala Leu Val Leu Pro Ser Ile Val Ile Leu Asp Leu Ser Val
     260                 265                 270

 gag gtt ctg gct tcc cca gct gct gcc tgg aaa tgc tta ggt gct aat     1521
 Glu Val Leu Ala Ser Pro Ala Ala Ala Trp Lys Cys Leu Gly Ala Asn
 275                 280                 285                 290

 atc ctg aga gga gga ttg tca gag ata gta ctc ccc ata gag tgg cag     1569
 Ile Leu Arg Gly Gly Leu Ser Glu Ile Val Leu Pro Ile Glu Trp Gln
                 295                 300                 305

 cag gac agg aag atc ccc cca ctc tcc acc ccg ccg cca ccg gcc atg     1617
 Gln Asp Arg Lys Ile Pro Pro Leu Ser Thr Pro Pro Pro Pro Ala Met
             310                 315                 320

 tgg aca gag gaa gcc ggg gcg acc gcc gag gcc cag gaa tcc ggc atc     1665
 Trp Thr Glu Glu Ala Gly Ala Thr Ala Glu Ala Gln Glu Ser Gly Ile
         325                 330                 335

 agg aac aag tct agc agt tcc agt caa atc ccg gtg gtt ggg gtg gtg     1713
 Arg Asn Lys Ser Ser Ser Ser Ser Gln Ile Pro Val Val Gly Val Val
     340                 345                 350

 acg gag gac gat gag gcg cag gat tcc att gat ccc cca gag agc cct     1761
 Thr Glu Asp Asp Glu Ala Gln Asp Ser Ile Asp Pro Pro Glu Ser Pro
 355                 360                 365                 370

 gat cgt gcc tta aaa gcc gcg aat tcc tgg agg aac cct gtc ctg cct     1809
 Asp Arg Ala Leu Lys Ala Ala Asn Ser Trp Arg Asn Pro Val Leu Pro
                 375                 380                 385

 cac act aat ggt gtg ggg cca ctg tgg gaa ttc ctg ttg agg ctt ctc     1857
 His Thr Asn Gly Val Gly Pro Leu Trp Glu Phe Leu Leu Arg Leu Leu
             390                 395                 400

 aaa tct cag gct gcg tca gga acc ctg tct ctt gcg ttc aca tcc tgg     1905
 Lys Ser Gln Ala Ala Ser Gly Thr Leu Ser Leu Ala Phe Thr Ser Trp
         405                 410                 415

 agc ctt gga gag ttc ctt ggg agt ggg aca tgg atg aag ctg gaa acc     1953
 Ser Leu Gly Glu Phe Leu Gly Ser Gly Thr Trp Met Lys Leu Glu Thr
     420                 425                 430

 ata att ctc agc aaa cta aca cag gaa cag aaa tcc aaa cac tgc atg     2001
 Ile Ile Leu Ser Lys Leu Thr Gln Glu Gln Lys Ser Lys His Cys Met
 435                 440                 445                 450

 ttc tca ctg ata agt ggg agc ttg cca ttt ttg aaa aag aaa gtg tcg     2049
 Phe Ser Leu Ile Ser Gly Ser Leu Pro Phe Leu Lys Lys Lys Val Ser
                 455                 460                 465

 gat gaa ata act tat gct gaa gat act gct aat tca att gca ctt ctg     2097
 Asp Glu Ile Thr Tyr Ala Glu Asp Thr Ala Asn Ser Ile Ala Leu Leu
             470                 475                 480

 ggt gac tta atg aaa ata cca agt tct gaa ttg agg ata caa att tgt     2145
 Gly Asp Leu Met Lys Ile Pro Ser Ser Glu Leu Arg Ile Gln Ile Cys
         485                 490                 495

 aag tgt att gtt gat ttt tat cat gca gaa cca cca aag aag cat att     2193
 Lys Cys Ile Val Asp Phe Tyr His Ala Glu Pro Pro Lys Lys His Ile
     500                 505                 510

 cca gaa gtt aat tgt act ata atg atg aaa gca caa gca gcc agt gga     2241
 Pro Glu Val Asn Cys Thr Ile Met Met Lys Ala Gln Ala Ala Ser Gly
 515                 520                 525                 530

 atc tgt act cac ctc aat gac cca gat ccc tct gga cag ctt tta ttt     2289
 Ile Cys Thr His Leu Asn Asp Pro Asp Pro Ser Gly Gln Leu Leu Phe
                 535                 540                 545

 cgt tca tca gaa ata ctt tgg aac ttg ctg gaa aaa tct tca aaa gaa     2337
 Arg Ser Ser Glu Ile Leu Trp Asn Leu Leu Glu Lys Ser Ser Lys Glu
             550                 555                 560

 gaa gtc ata caa cag ctt agt aac ttg gaa tgt ttg ctg gct ttg aag     2385
 Glu Val Ile Gln Gln Leu Ser Asn Leu Glu Cys Leu Leu Ala Leu Lys
         565                 570                 575

 gaa gta ttt aaa aat ctg ttt atg aga ggt ttc agt cat tat gac cgt     2433
 Glu Val Phe Lys Asn Leu Phe Met Arg Gly Phe Ser His Tyr Asp Arg
     580                 585                 590

 cag ctt aga aat gac ata tta gtg atc act aca att ata gct caa aat     2481
 Gln Leu Arg Asn Asp Ile Leu Val Ile Thr Thr Ile Ile Ala Gln Asn
 595                 600                 605                 610

 cct gaa gca cca atg att gaa tgt ggc ttt acc aag gat ttg ata ctg     2529
 Pro Glu Ala Pro Met Ile Glu Cys Gly Phe Thr Lys Asp Leu Ile Leu
                 615                 620                 625

 ttt gcc acc ttt aat gaa gtt aaa agt caa aat ctt ttg gta aaa gga     2577
 Phe Ala Thr Phe Asn Glu Val Lys Ser Gln Asn Leu Leu Val Lys Gly
             630                 635                 640

 ctt aag ctt tct aat tcc tat gaa gat ttt gag ttg aag aaa tta cta     2625
 Leu Lys Leu Ser Asn Ser Tyr Glu Asp Phe Glu Leu Lys Lys Leu Leu
         645                 650                 655

 ttc aat gta att gtg atc tta tgt aaa gat tta cct act gta cag cta     2673
 Phe Asn Val Ile Val Ile Leu Cys Lys Asp Leu Pro Thr Val Gln Leu
     660                 665                 670

 tta att gat ggc aaa gtt att ttg gct ttg ttt acc tat gtt aag aag     2721
 Leu Ile Asp Gly Lys Val Ile Leu Ala Leu Phe Thr Tyr Val Lys Lys
 675                 680                 685                 690

 cct gag aag caa aaa ata att gac tgg tct gca gca cag cat gaa gaa     2769
 Pro Glu Lys Gln Lys Ile Ile Asp Trp Ser Ala Ala Gln His Glu Glu
                 695                 700                 705

 tta caa ctg cat gca att gcc act ttg tca tca gtg gct cct tta tta     2817
 Leu Gln Leu His Ala Ile Ala Thr Leu Ser Ser Val Ala Pro Leu Leu
             710                 715                 720

 ata gaa gaa tac atg tca tgc cag gga aat gct cga gtc ctt gca ttt     2865
 Ile Glu Glu Tyr Met Ser Cys Gln Gly Asn Ala Arg Val Leu Ala Phe
         725                 730                 735

 cta gaa tgg tgt gag agt gaa gat ccg ttt ttc agt cat ggt aac agt     2913
 Leu Glu Trp Cys Glu Ser Glu Asp Pro Phe Phe Ser His Gly Asn Ser
     740                 745                 750

 ttt cat ggt aca ggt ggc cga ggc aac aag ttt gcc cag atg cgt tac     2961
 Phe His Gly Thr Gly Gly Arg Gly Asn Lys Phe Ala Gln Met Arg Tyr
 755                 760                 765                 770

 agt tta aga ctc ctg aga gcc atg gtc tac ctt gaa gat gag act gta     3009
 Ser Leu Arg Leu Leu Arg Ala Met Val Tyr Leu Glu Asp Glu Thr Val
                 775                 780                 785

 aac aaa gat ctt tgt gaa aag gga aca att cag caa atg ata ggt ctt     3057
 Asn Lys Asp Leu Cys Glu Lys Gly Thr Ile Gln Gln Met Ile Gly Leu
             790                 795                 800

 cat gac ctg tat ctt gtg cga cct cct atc tca tcc tgt gac tta gaa     3105
 His Asp Leu Tyr Leu Val Arg Pro Pro Ile Ser Ser Cys Asp Leu Glu
         805                 810                 815

 tgc cgt gac cat ctg gga atg cag cac agt acc cct ctt tat gac aga     3153
 Cys Arg Asp His Leu Gly Met Gln His Ser Thr Pro Leu Tyr Asp Arg
     820                 825                 830

 aca ata cag aaa gac aaa gta cac cag att ggc tac agg tta aga tta     3201
 Thr Ile Gln Lys Asp Lys Val His Gln Ile Gly Tyr Arg Leu Arg Leu
 835                 840                 845                 850

 ggc ttt caa atc att tct ccc att aat caa aac ttt aca gag gag aca     3249
 Gly Phe Gln Ile Ile Ser Pro Ile Asn Gln Asn Phe Thr Glu Glu Thr
                 855                 860                 865

 gtg att ttt acc att cat tca act ggt ttg cac aga ggg gaa ggg aag     3297
 Val Ile Phe Thr Ile His Ser Thr Gly Leu His Arg Gly Glu Gly Lys
             870                 875                 880

 gga aaa agg gaa ggg agc att gct ttt ggc agt gtg ggg aag att gga     3345
 Gly Lys Arg Glu Gly Ser Ile Ala Phe Gly Ser Val Gly Lys Ile Gly
         885                 890                 895

 gaa ata tgg aat gaa ata tat gaa gaa ata aaa tta gaa aaa tta aga     3393
 Glu Ile Trp Asn Glu Ile Tyr Glu Glu Ile Lys Leu Glu Lys Leu Arg
     900                 905                 910

 cca gtc act aca gat aaa aaa gct ttg gaa gct att aca aca gca tca     3441
 Pro Val Thr Thr Asp Lys Lys Ala Leu Glu Ala Ile Thr Thr Ala Ser
 915                 920                 925                 930

 gaa aat att gga aag atg gtt gct tct ctg caa agt gat ata att gaa     3489
 Glu Asn Ile Gly Lys Met Val Ala Ser Leu Gln Ser Asp Ile Ile Glu
                 935                 940                 945

 agc caa gca tgc caa gac atg caa aat gaa caa aaa gta tat gca aaa     3537
 Ser Gln Ala Cys Gln Asp Met Gln Asn Glu Gln Lys Val Tyr Ala Lys
             950                 955                 960

 ata cag gcc acg cac aag caa aga gag ctg gct aat aaa tca tgg gaa     3585
 Ile Gln Ala Thr His Lys Gln Arg Glu Leu Ala Asn Lys Ser Trp Glu
         965                 970                 975

 gat ttc ttg gct aga aca tca aac gct aaa acg tta aag aaa gca aaa     3633
 Asp Phe Leu Ala Arg Thr Ser Asn Ala Lys Thr Leu Lys Lys Ala Lys
     980                 985                 990

 agc ctt caa gaa aaa gct ata gaa gcc tcc aga tac cat aaa cga cca     3681
 Ser Leu Gln Glu Lys Ala Ile Glu Ala Ser Arg Tyr His Lys Arg Pro
 995                1000                1005                1010

 caa aat gca ata ttt cac caa aca cat att aaa ggc ctt aac aca acg     3729
 Gln Asn Ala Ile Phe His Gln Thr His Ile Lys Gly Leu Asn Thr Thr
                1015                1020                1025

 gtg ccc tct ggt gga gta gta aca gtg gaa agc act cct gcc cga tta     3777
 Val Pro Ser Gly Gly Val Val Thr Val Glu Ser Thr Pro Ala Arg Leu
            1030                1035                1040

 gta gga gga cct ctg gtt gat acg gat att gct ctt aaa aaa ctg ccc     3825
 Val Gly Gly Pro Leu Val Asp Thr Asp Ile Ala Leu Lys Lys Leu Pro
        1045                1050                1055

 att cga gga gga gcc ttg cag agg gtg aaa gca gtt aaa att gtg gat     3873
 Ile Arg Gly Gly Ala Leu Gln Arg Val Lys Ala Val Lys Ile Val Asp
    1060                1065                1070

 gca cca aaa aag agt att cct acg taa tatac tatagagact ttttgaaata     3925
 Ala Pro Lys Lys Ser Ile Pro Thr 
1075                1080

 aagtcagctt ataatttttt agctgaaaaa aaaaaaa                            3962




      <210> 76
      <211> 2101
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (336)..(1346)

      <400> 76
 acttgaatga agcagtccca gagacagagc gcctggattc aaaagcactg aaaactcgag     60

 cccagctctc tgtgaagaac agacgccaga gaccctctag gacaagactg tatgatagtg    120

 ttagttccac agatggggag gacagtctag agagaaagcc atcaaacagt ttctataacc    180

 acatgcatat taccaaatta cttccaccta agggtttgag aacgtcttct ccagaatcag    240

 attctggtgt tccacccctc accccggtgg atagcaatgt gcccttctcg tctgaccaca    300

 tagctgaatt tcaagaagaa ccactggacc cagaa   atg ggg cct ctc tcc tct     353
                                          Met Gly Pro Leu Ser Ser
                                            1               5

 atg tgg gga gac act tca ctg ttt tct act tca aag tct gat cat gat      401
 Met Trp Gly Asp Thr Ser Leu Phe Ser Thr Ser Lys Ser Asp His Asp
              10                  15                  20

 gtg gaa gaa tct cct tgc cat cac caa acc acc aac aag aaa ata tta      449
 Val Glu Glu Ser Pro Cys His His Gln Thr Thr Asn Lys Lys Ile Leu
          25                  30                  35

 cga gaa aaa gat gat gcc aaa gat ccc aaa tca cta agg gca tcc agt      497
 Arg Glu Lys Asp Asp Ala Lys Asp Pro Lys Ser Leu Arg Ala Ser Ser
      40                  45                  50

 tca ttg gcg gtg caa gga gga aaa att aag cgg aag ttt gtg gat ctg      545
 Ser Leu Ala Val Gln Gly Gly Lys Ile Lys Arg Lys Phe Val Asp Leu
  55                  60                  65                  70

 ggg gcg cct ttg cga agg aat tcc agc aag gga aag aag tgg aaa gaa      593
 Gly Ala Pro Leu Arg Arg Asn Ser Ser Lys Gly Lys Lys Trp Lys Glu
                  75                  80                  85

 aaa gaa aaa gaa gcc agt agg ttt tct gca ggt agc agg atc ttc aga      641
 Lys Glu Lys Glu Ala Ser Arg Phe Ser Ala Gly Ser Arg Ile Phe Arg
              90                  95                 100

 ggc aga ctg gaa aac tgg aca ccc aag cca tgt tca aca gct cag acc      689
 Gly Arg Leu Glu Asn Trp Thr Pro Lys Pro Cys Ser Thr Ala Gln Thr
         105                 110                 115

 tcc act cgt tcc cct tgc atg cct ttc tca tgg ttt aat gac agc cgg      737
 Ser Thr Arg Ser Pro Cys Met Pro Phe Ser Trp Phe Asn Asp Ser Arg
     120                 125                 130

 aaa gga tcc tat tcc ttc agg aac ctg cct gcg cct aca agt tcc ctt      785
 Lys Gly Ser Tyr Ser Phe Arg Asn Leu Pro Ala Pro Thr Ser Ser Leu
 135                 140                 145                 150

 cag cct tct cct gag act cta att tca gat aaa aag ggg tcc aag aat      833
 Gln Pro Ser Pro Glu Thr Leu Ile Ser Asp Lys Lys Gly Ser Lys Asn
                 155                 160                 165

 ttt acc ttc aat gat gac ttc agt ccc agc agt acc agt tca gca gac      881
 Phe Thr Phe Asn Asp Asp Phe Ser Pro Ser Ser Thr Ser Ser Ala Asp
             170                 175                 180

 ctc agc ggc tta gga gca gaa cct aaa aca cca ggg ctc tct cag ccc      929
 Leu Ser Gly Leu Gly Ala Glu Pro Lys Thr Pro Gly Leu Ser Gln Pro
         185                 190                 195

 tta gca ctg tca tca gat gag atc ctt gat gat gga cag tct ccc aaa      977
 Leu Ala Leu Ser Ser Asp Glu Ile Leu Asp Asp Gly Gln Ser Pro Lys
     200                 205                 210

 cac agt cag tgt cag aat cgg gcc gtt cag gaa tgg agt gtg cag cag     1025
 His Ser Gln Cys Gln Asn Arg Ala Val Gln Glu Trp Ser Val Gln Gln
 215                 220                 225                 230

 gtt tct cac tgg tta atg agc cta aat ctg gag cag tat gta tct gaa     1073
 Val Ser His Trp Leu Met Ser Leu Asn Leu Glu Gln Tyr Val Ser Glu
                 235                 240                 245

 ttc agt gcc caa aac atc act gga gaa cag ctc ctg cag ttg gat gga     1121
 Phe Ser Ala Gln Asn Ile Thr Gly Glu Gln Leu Leu Gln Leu Asp Gly
             250                 255                 260

 aat aaa ctt aag gct ctt gga atg aca gca tcc cag gac cga gca gtg     1169
 Asn Lys Leu Lys Ala Leu Gly Met Thr Ala Ser Gln Asp Arg Ala Val
         265                 270                 275

 gtc aaa aag aaa ctc aag gaa atg aag atg tct cta gag aag gct cgg     1217
 Val Lys Lys Lys Leu Lys Glu Met Lys Met Ser Leu Glu Lys Ala Arg
     280                 285                 290

 aag gcc caa gag aaa atg gaa aaa caa aga gaa aag cta agg aga aag     1265
 Lys Ala Gln Glu Lys Met Glu Lys Gln Arg Glu Lys Leu Arg Arg Lys
 295                 300                 305                 310

 gag caa gag caa atg cag agg aag tcc aaa aag aca gaa aag atg acg     1313
 Glu Gln Glu Gln Met Gln Arg Lys Ser Lys Lys Thr Glu Lys Met Thr
                 315                 320                 325

 tca act aca gcc gag ggt gct ggt gag cag taa cacatacc ctcttacaga     1364
 Ser Thr Thr Ala Glu Gly Ala Gly Glu Gln 
             330                 335

 tgatggagat gctccaagag aagtccccac ctcttcctgc cctgctctcc tccagaggat   1424

 gaaaaagaaa ctaaatgata agggtaatgc ggctctaggc cggctgagga actgtgtgtt   1484

 gaataactgc attttctgca atagaatgca ctcttaattt taactactaa aataatccca   1544

 agccaccttt ggttcattaa caaaccagag atttcattta agtagctgtg ttttgctctt   1604

 ctctaactta ccaacatctt gtgttgtgtt gggtgtgttt tgtcacttgg agaactagtg   1664

 tgaccccacc caagagcatg acacaccctg gtgttgttaa tggagcgccg tgaattttca   1724

 gtgtgggatc ctgaaatggc aattgcacat gtctgcatgg cagagagcac cctgccatga   1784

 gatctgagac cagtacttaa cttctaggac tgcaacacct actccaatgt gtgggaaaga   1844

 tttgctctta attctcagtc tggacagtga gaccaccccg ctgtggaaac atgggtgctc   1904

 tgctctgtag ttacctacta agggaaaagg caagcaagtc attctgcttg ctaggcatca   1964

 aaaagaaaga aaaaaaatta tagctatttg ttaaccactg aaaaaagcaa aagccttaag   2024

 aatgtggatg tgggtattac cttggggttc tgagggtaat atttatcctc tagatacggc   2084

 tgaacaaaaa aaaaaaa                                                  2101




      <210> 77
      <211> 3087
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (544)..(2964)

      <400> 77
 ccgcaattcc cgggtcgacg agttcgtgtt tcagtaaaag atgatgaaag ccactatcaa     60

 ttctcactgc tgagtggcag ggagaagcag caccactctc agctcttttc taatcttgta    120

 acttagtgct agaagtctct ccaggctatt accatgggca tttgttctct gttggagctg    180

 taagcagatg aacccaagta gagaagatag atcttggaag gagagatcca ttgagtccag    240

 aagccagatc agcaaatgga ggaacctcgg aggtgaccag aaagatctcc atcggttgcc    300

 caaggctagc cttggaggag cctccctcgg ggtcaggaat cgagcgggga caccgctggg    360

 ccactcggaa ggaccgtttc ctggggactg atcaagagga gggaaggtcc tattacagcc    420

 cagaggccac gtggggcctg agccccaaac ctcagctgct gttccagcag ccccgtagct    480

 gggtggagcc tccgggcctg acgtgggcct tcactggaga agtgactcag ggatcctccc    540

 agg  atg tct gcc tca cca gac gac ctg agt aca ggg gga agg tta cag     588
      Met Ser Ala Ser Pro Asp Asp Leu Ser Thr Gly Gly Arg Leu Gln
        1               5                  10                  15

 aac atg aca gtg gat gaa tgc ttc cag tct cgg aac acc gtc ctc cag      636
 Asn Met Thr Val Asp Glu Cys Phe Gln Ser Arg Asn Thr Val Leu Gln
                  20                  25                  30

 ggg cag ccc ttt ggg ggt gtc ccc acc gtg ctg tgc ctc aac atc gcc      684
 Gly Gln Pro Phe Gly Gly Val Pro Thr Val Leu Cys Leu Asn Ile Ala
              35                  40                  45

 ctg tgg gtg ctc gtc ctt gtg gtt tac tcc ttc ctc cgg aaa gct gcg      732
 Leu Trp Val Leu Val Leu Val Val Tyr Ser Phe Leu Arg Lys Ala Ala
          50                  55                  60

 tgg gac tat ggg cgc ctg gct ctg ctg ata cac aat gac agc ctg acc      780
 Trp Asp Tyr Gly Arg Leu Ala Leu Leu Ile His Asn Asp Ser Leu Thr
      65                  70                  75

 tcg ctg atc tat ggg gag cag agc gag aag aca tct ccc tcg gag act      828
 Ser Leu Ile Tyr Gly Glu Gln Ser Glu Lys Thr Ser Pro Ser Glu Thr
  80                  85                  90                  95

 tcc ttg gag atg gaa cgc aga gac aag gga ttc tgt tcc tgg ttc ttc      876
 Ser Leu Glu Met Glu Arg Arg Asp Lys Gly Phe Cys Ser Trp Phe Phe
                 100                 105                 110

 aac agc ata aca atg aag gac gag gat ctg att aac aag tgt ggg gac      924
 Asn Ser Ile Thr Met Lys Asp Glu Asp Leu Ile Asn Lys Cys Gly Asp
             115                 120                 125

 gac gcg cgc atc tac atc gtg ttc cag tac cac ctc atc atc ttt gtg      972
 Asp Ala Arg Ile Tyr Ile Val Phe Gln Tyr His Leu Ile Ile Phe Val
         130                 135                 140

 ctc atc atc tgt atc ccc tcc ctg ggc atc att ttg ccc atc aac tat     1020
 Leu Ile Ile Cys Ile Pro Ser Leu Gly Ile Ile Leu Pro Ile Asn Tyr
     145                 150                 155

 act gga tct gtt ctg gac tgg agc agt cac ttt gct cgg acc acc att     1068
 Thr Gly Ser Val Leu Asp Trp Ser Ser His Phe Ala Arg Thr Thr Ile
 160                 165                 170                 175

 gtc aat gtc tcc aca gag agc aag ctc ctg tgg ctg cat agc ctg ctg     1116
 Val Asn Val Ser Thr Glu Ser Lys Leu Leu Trp Leu His Ser Leu Leu
                 180                 185                 190

 tcc ttc ttc tac ttc atc acc aac ttc atg ttc atg gct cat cac tgc     1164
 Ser Phe Phe Tyr Phe Ile Thr Asn Phe Met Phe Met Ala His His Cys
             195                 200                 205

 ctg ggg ttt gcg ccc agg aat agc caa aag gtc aca agg aca cta atg     1212
 Leu Gly Phe Ala Pro Arg Asn Ser Gln Lys Val Thr Arg Thr Leu Met
         210                 215                 220

 atc acc tat gtg ccc aag gac att gaa gac cca gaa ctc atc att aag     1260
 Ile Thr Tyr Val Pro Lys Asp Ile Glu Asp Pro Glu Leu Ile Ile Lys
     225                 230                 235

 cat ttt cac gag gcc tat cca ggc agt gtc gtg aca aga gtc cac ttc     1308
 His Phe His Glu Ala Tyr Pro Gly Ser Val Val Thr Arg Val His Phe
 240                 245                 250                 255

 tgc tac gac gtc agg aac ctg atc gac ttg gac gat cag agg cgc cat     1356
 Cys Tyr Asp Val Arg Asn Leu Ile Asp Leu Asp Asp Gln Arg Arg His
                 260                 265                 270

 gcc atg cgg ggc cgg ctt ttc tat aca gcc aag gcc aag aag act ggg     1404
 Ala Met Arg Gly Arg Leu Phe Tyr Thr Ala Lys Ala Lys Lys Thr Gly
             275                 280                 285

 aag gtg atg atc agg atc cac ccc tgt gcc cgc ctg tgc ttc tgc aag     1452
 Lys Val Met Ile Arg Ile His Pro Cys Ala Arg Leu Cys Phe Cys Lys
         290                 295                 300

 tgc tgg acc tgc ttc aag gag gtg gat gca gag cag tat tac agc gag     1500
 Cys Trp Thr Cys Phe Lys Glu Val Asp Ala Glu Gln Tyr Tyr Ser Glu
     305                 310                 315

 cta gag gag cag cta acg gac gag ttc aac gcc gag ctc aac cgc gtg     1548
 Leu Glu Glu Gln Leu Thr Asp Glu Phe Asn Ala Glu Leu Asn Arg Val
 320                 325                 330                 335

 ccg ctc aag cgg ctg gac ctg atc ttt gtc acc ttc cag gac tcc agg     1596
 Pro Leu Lys Arg Leu Asp Leu Ile Phe Val Thr Phe Gln Asp Ser Arg
                 340                 345                 350

 atg gcc aag cgt gtc cgt aag gat tac aag tat gtc cag tgt ggt gtg     1644
 Met Ala Lys Arg Val Arg Lys Asp Tyr Lys Tyr Val Gln Cys Gly Val
             355                 360                 365

 caa ccc cag cag tcc tca gtg acc acc atc gtc aaa tca tat tac tgg     1692
 Gln Pro Gln Gln Ser Ser Val Thr Thr Ile Val Lys Ser Tyr Tyr Trp
         370                 375                 380

 agg gtc act atg gcc cca cac ccc aaa gac att att tgg aaa cac ctg     1740
 Arg Val Thr Met Ala Pro His Pro Lys Asp Ile Ile Trp Lys His Leu
     385                 390                 395

 tct gtc cgc cgc ttc ttt tgg tgg gcc cgc ttt atc gca atc aac acc     1788
 Ser Val Arg Arg Phe Phe Trp Trp Ala Arg Phe Ile Ala Ile Asn Thr
 400                 405                 410                 415

 ttc ctc ttc ttc ctc ttc ttc ttt ctc acc acg cct gcc atc atc atg     1836
 Phe Leu Phe Phe Leu Phe Phe Phe Leu Thr Thr Pro Ala Ile Ile Met
                 420                 425                 430

 aac act atc gac atg tac aac gtc acc cgc ccc atc gag aag ctg cag     1884
 Asn Thr Ile Asp Met Tyr Asn Val Thr Arg Pro Ile Glu Lys Leu Gln
             435                 440                 445

 aac cca att gtg acc cag ttc ttc ccc tct gtg atg ctc tgg ggc ttc     1932
 Asn Pro Ile Val Thr Gln Phe Phe Pro Ser Val Met Leu Trp Gly Phe
         450                 455                 460

 aca gtg ata ctg cct ctg att gtc tac ttc tcc gcc ttc ctc gag gcc     1980
 Thr Val Ile Leu Pro Leu Ile Val Tyr Phe Ser Ala Phe Leu Glu Ala
     465                 470                 475

 cac tgg acc aga tca agt cag aat ctg gtc atg gtg cac aag tgc tac     2028
 His Trp Thr Arg Ser Ser Gln Asn Leu Val Met Val His Lys Cys Tyr
 480                 485                 490                 495

 atc ttt ctg gtg ttc atg gta gtc att ctg ccc tct atg gga ctg acc     2076
 Ile Phe Leu Val Phe Met Val Val Ile Leu Pro Ser Met Gly Leu Thr
                 500                 505                 510

 agt ttg gat gtc ttt ctc cgc tgg ctc ttt gac atc tac tat cta gag     2124
 Ser Leu Asp Val Phe Leu Arg Trp Leu Phe Asp Ile Tyr Tyr Leu Glu
             515                 520                 525

 caa gca tcc atc agg ttc cag tgt gtg ttc ctg cca gac aac ggc gcc     2172
 Gln Ala Ser Ile Arg Phe Gln Cys Val Phe Leu Pro Asp Asn Gly Ala
         530                 535                 540

 ttc ttt gtc aac tac gtg atc acg gca gct tta ctt ggc aca ggc atg     2220
 Phe Phe Val Asn Tyr Val Ile Thr Ala Ala Leu Leu Gly Thr Gly Met
     545                 550                 555

 gag ctg ctg cgt ctg ggg tca ctc ttc tgc tac agc acc cgc ctc ttc     2268
 Glu Leu Leu Arg Leu Gly Ser Leu Phe Cys Tyr Ser Thr Arg Leu Phe
 560                 565                 570                 575

 ttc tct aga tca gag cca gag aga gtc aac atc aga aag aac cag gcc     2316
 Phe Ser Arg Ser Glu Pro Glu Arg Val Asn Ile Arg Lys Asn Gln Ala
                 580                 585                 590

 ata gac ttc cag ttt ggg cgt gag tat gcg tgg atg atg aac gtg ttc     2364
 Ile Asp Phe Gln Phe Gly Arg Glu Tyr Ala Trp Met Met Asn Val Phe
             595                 600                 605

 agc gtg gtg atg gcg tac agc atc act tgc ccc atc att gtg cct ttt     2412
 Ser Val Val Met Ala Tyr Ser Ile Thr Cys Pro Ile Ile Val Pro Phe
         610                 615                 620

 ggg ttg ctc tac ctg tgc atg aag cac ttg acg gat cgc tat aac atg     2460
 Gly Leu Leu Tyr Leu Cys Met Lys His Leu Thr Asp Arg Tyr Asn Met
     625                 630                 635

 tac tac tcc ttt gca ccc acc aaa ctg aac gag cag atc cac atg gct     2508
 Tyr Tyr Ser Phe Ala Pro Thr Lys Leu Asn Glu Gln Ile His Met Ala
 640                 645                 650                 655

 gcc gtc tcc cag gcc atc ttt gcg cca ctc ttg ggt ctg ttc tgg atg     2556
 Ala Val Ser Gln Ala Ile Phe Ala Pro Leu Leu Gly Leu Phe Trp Met
                 660                 665                 670

 ctg ttc ttc tcc atc ctg cgg ttg ggt tct ctc cac gcc atc acc atc     2604
 Leu Phe Phe Ser Ile Leu Arg Leu Gly Ser Leu His Ala Ile Thr Ile
             675                 680                 685

 ttt tcc ctg tcc acc ctc ctc att gcc atg gtg att gcc ttt gtt ggc     2652
 Phe Ser Leu Ser Thr Leu Leu Ile Ala Met Val Ile Ala Phe Val Gly
         690                 695                 700

 att ttt ctg ggg aag ctt cgg atg gtt gcc gac tac gag ccc gag gag     2700
 Ile Phe Leu Gly Lys Leu Arg Met Val Ala Asp Tyr Glu Pro Glu Glu
     705                 710                 715

 gag gag atc cag aca gtg ttt gac atg gag cca agc agc acc tcc tcc     2748
 Glu Glu Ile Gln Thr Val Phe Asp Met Glu Pro Ser Ser Thr Ser Ser
 720                 725                 730                 735

 acg ccc acc tcc ctc ctg tat gtg gcc acc gtg ctg caa gaa ccg gag     2796
 Thr Pro Thr Ser Leu Leu Tyr Val Ala Thr Val Leu Gln Glu Pro Glu
                 740                 745                 750

 ttg aat ctg acc ccc gcc tcc tcc cca gcc agg cac acc tat ggc acc     2844
 Leu Asn Leu Thr Pro Ala Ser Ser Pro Ala Arg His Thr Tyr Gly Thr
             755                 760                 765

 atg aac aac cag ccg gaa gag gga gaa gaa gag agt ggt ctg agg ggc     2892
 Met Asn Asn Gln Pro Glu Glu Gly Glu Glu Glu Ser Gly Leu Arg Gly
         770                 775                 780

 ttt gcg agg gag cta gac tcg gcc cag ttc cag gaa ggg ctg gaa ctg     2940
 Phe Ala Arg Glu Leu Asp Ser Ala Gln Phe Gln Glu Gly Leu Glu Leu
     785                 790                 795

 gag ggc cag aac cag tac cac tga ccgggacctg aggcctccac tggcgacttg    2994
 Glu Gly Gln Asn Gln Tyr His 
 800                 805

 ttgaggggtc aggggagggc ctggcaaggg gaggcaggag ggtggcctgg acctccccac   3054

 tacctcctgc agactttgag aagcctacag tgg                                3087




      <210> 78
      <211> 1625
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (164)..(1402)

      <400> 78
 gtggcgcctg ctctccatcc aggccccatt ccggctccca cccgacgctg cttttgttcc     60

 cacgtttcgg ggggcagctg gcactgtgat tcctgcccca tgagtgccta gaggcacgga    120

 gccaccaggg atcaccccac gtgggacaca gggcttgggg agg  atg ggg cag gac     175
                                                  Met Gly Gln Asp
                                                    1

 cag acc aag cag cag atc gag aag ggg ctc cag ctg tac cag tcc aac      223
 Gln Thr Lys Gln Gln Ile Glu Lys Gly Leu Gln Leu Tyr Gln Ser Asn
   5                  10                  15                  20

 cag aca gag aag gca ttg cag gtg tgg aca aag gtg ctg gag aag agc      271
 Gln Thr Glu Lys Ala Leu Gln Val Trp Thr Lys Val Leu Glu Lys Ser
                  25                  30                  35

 tcg gac ctc atg ggg cgc ttc cgc gtg ctg ggc tgc ctg gtc aca gcc      319
 Ser Asp Leu Met Gly Arg Phe Arg Val Leu Gly Cys Leu Val Thr Ala
              40                  45                  50

 cac tcg gag atg ggc cgc tac aag gag atg ctg aag ttc gct gtg gtc      367
 His Ser Glu Met Gly Arg Tyr Lys Glu Met Leu Lys Phe Ala Val Val
          55                  60                  65

 cag atc gac acg gcc cgg gag ctg gag gat gcc gac ttc ctc ctg gag      415
 Gln Ile Asp Thr Ala Arg Glu Leu Glu Asp Ala Asp Phe Leu Leu Glu
      70                  75                  80

 agc tac ctg aac ctg gca cgc agc aac gag aag ctg tgc gag ttt cac      463
 Ser Tyr Leu Asn Leu Ala Arg Ser Asn Glu Lys Leu Cys Glu Phe His
  85                  90                  95                 100

 aag acc atc tcc tac tgc aag acc tgc ctt ggc gtg cca ggt acc agg      511
 Lys Thr Ile Ser Tyr Cys Lys Thr Cys Leu Gly Val Pro Gly Thr Arg
                 105                 110                 115

 gca ggt gcc cag ctc gga ggc cag gtc agc ctg agc atg ggc aat gcc      559
 Ala Gly Ala Gln Leu Gly Gly Gln Val Ser Leu Ser Met Gly Asn Ala
             120                 125                 130

 ttc ctg ggc ctc agc gtc ttc cag aag gcc ctg gag agc ttc gag aag      607
 Phe Leu Gly Leu Ser Val Phe Gln Lys Ala Leu Glu Ser Phe Glu Lys
         135                 140                 145

 gcc ctg cgc tac gcg cac aac aat gat gac acc atg ctc gag tgc cgc      655
 Ala Leu Arg Tyr Ala His Asn Asn Asp Asp Thr Met Leu Glu Cys Arg
     150                 155                 160

 gtg tgc tgc agc ctg ggc agc ttc tat gcc cag gtc aag gac tac gag      703
 Val Cys Cys Ser Leu Gly Ser Phe Tyr Ala Gln Val Lys Asp Tyr Glu
 165                 170                 175                 180

 aaa gcc ctg ttc ttc ccc tgc aag gcg gca gag ctt gtc aac aac tat      751
 Lys Ala Leu Phe Phe Pro Cys Lys Ala Ala Glu Leu Val Asn Asn Tyr
                 185                 190                 195

 ggc aaa ggc tgg agc ctg aag tac cgg gcc atg agc cag tac cac atg      799
 Gly Lys Gly Trp Ser Leu Lys Tyr Arg Ala Met Ser Gln Tyr His Met
             200                 205                 210

 gcc gtg gcc tat cgc ctg ctg ggc cgc ctg ggc agt gcc atg gag tgt      847
 Ala Val Ala Tyr Arg Leu Leu Gly Arg Leu Gly Ser Ala Met Glu Cys
         215                 220                 225

 tgt gag gag tct atg aag atc gcg ctg cag cac ggg gac cgg cca ctg      895
 Cys Glu Glu Ser Met Lys Ile Ala Leu Gln His Gly Asp Arg Pro Leu
     230                 235                 240

 cag gcg ctc tgc ctg ctc tgc ttc gct gac atc cac cgg agc cgt ggg      943
 Gln Ala Leu Cys Leu Leu Cys Phe Ala Asp Ile His Arg Ser Arg Gly
 245                 250                 255                 260

 gac ctg gag aca gcc ttc ccc agg tac gac tcc gcc atg agc atc atg      991
 Asp Leu Glu Thr Ala Phe Pro Arg Tyr Asp Ser Ala Met Ser Ile Met
                 265                 270                 275

 acc gag atc gga aac cgc ctg ggg cag gtg cag gcg ctg ctg ggt gtg     1039
 Thr Glu Ile Gly Asn Arg Leu Gly Gln Val Gln Ala Leu Leu Gly Val
             280                 285                 290

 gcc aag tgc tgg gtg gcc agg aag gcg ctg gac aag gct ctg gat gcc     1087
 Ala Lys Cys Trp Val Ala Arg Lys Ala Leu Asp Lys Ala Leu Asp Ala
         295                 300                 305

 atc gag aga gcc cag gat ctg gcc gag gag gtg ggg aac aag ctg agc     1135
 Ile Glu Arg Ala Gln Asp Leu Ala Glu Glu Val Gly Asn Lys Leu Ser
     310                 315                 320

 cag ctc aag ctg cac tgt ctg agc gag agc att tac cgc agc aaa ggg     1183
 Gln Leu Lys Leu His Cys Leu Ser Glu Ser Ile Tyr Arg Ser Lys Gly
 325                 330                 335                 340

 ctg cag cgg gaa ctg cgg gcg cac gtt gtg agg ttc cac gag tgc gtg     1231
 Leu Gln Arg Glu Leu Arg Ala His Val Val Arg Phe His Glu Cys Val
                 345                 350                 355

 gag gag acg gag ctc tac tgc ggc ctg tgc ggc gag tcc ata ggc gag     1279
 Glu Glu Thr Glu Leu Tyr Cys Gly Leu Cys Gly Glu Ser Ile Gly Glu
             360                 365                 370

 aag aac agc cgg ctg cag gcc cta ccc tgc tcc cac atc ttc cac ctc     1327
 Lys Asn Ser Arg Leu Gln Ala Leu Pro Cys Ser His Ile Phe His Leu
         375                 380                 385

 agg tgc ctg cag aac aac ggg acc cgg agc tgt ccc aac tgc cgc cgc     1375
 Arg Cys Leu Gln Asn Asn Gly Thr Arg Ser Cys Pro Asn Cys Arg Arg
     390                 395                 400

 tca tcc atg aag cct ggc ttt gta tga ctcct ggcagcaggc gtgggcttcc     1427
 Ser Ser Met Lys Pro Gly Phe Val 
 405                 410

 tcctcgccac tcctgctctt tctccactgc acgccagagg cccatttact cctggggcag   1487

 ctgccaggtc gtcctcacca tagccaaggc cttggggcct gcccagggct gctcccctgg   1547

 gcccagctcc cctccctgcc tctttgtact ttgctcttta tagaaaaata aactgtttgt   1607

 acctggaaaa aaaaaaaa                                                 1625




      <210> 79
      <211> 1639
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (337)..(1494)

      <400> 79
 atgcgccttt ctcattggcc gcgccgcttg ctagcttcgg gcggagggga gcgccgggcc     60

 gacggtgggc ggtcacgtga cggttacgac tgcactctcg ctggtgtcgg tgggcggtca    120

 cgtgatggtt atggccgcac tctcgctggt ggcggcctgt tgggccaacc ttttggggtg    180

 tgtgtgaatg gagctgtgga catttgctgt ccctgggcct tgtctcaggc acaagcgatg    240

 atggtggtgg cagctctgtc ccaggctgac ttcctgccag ctgctccagg ctattcctgg    300

 gcggctccag ggagcagtgt cagggccagg gagacg  atg gtc tcc gtg act atg     354
                                          Met Val Ser Val Thr Met
                                            1               5

 gcc act tcc gag tgg atc cag ttc ttt aag gaa gcc ggc att cct cca      402
 Ala Thr Ser Glu Trp Ile Gln Phe Phe Lys Glu Ala Gly Ile Pro Pro
              10                  15                  20

 gga cct gcc gtc aat tat gcc gtg atg ttt gtg gat aat agg att cag      450
 Gly Pro Ala Val Asn Tyr Ala Val Met Phe Val Asp Asn Arg Ile Gln
          25                  30                  35

 aag agc atg ctg ctg gat ctc aat aag gag ata atg aat gag ctg ggc      498
 Lys Ser Met Leu Leu Asp Leu Asn Lys Glu Ile Met Asn Glu Leu Gly
      40                  45                  50

 gtg acc gtg gtg ggt gac atc atc gcc att ctc aag cat gcc aaa gtg      546
 Val Thr Val Val Gly Asp Ile Ile Ala Ile Leu Lys His Ala Lys Val
  55                  60                  65                  70

 gtg cac cgt cag gac atg tgc aaa gct gcc act gag tca gta ccc tgc      594
 Val His Arg Gln Asp Met Cys Lys Ala Ala Thr Glu Ser Val Pro Cys
                  75                  80                  85

 agc cct agc ccc ctt gca ggc gaa att cgc cgt ggc acc agt gct gcc      642
 Ser Pro Ser Pro Leu Ala Gly Glu Ile Arg Arg Gly Thr Ser Ala Ala
              90                  95                 100

 tcc cga atg atc acc aac agc ctg aac cat gac tct cca ccc agc aca      690
 Ser Arg Met Ile Thr Asn Ser Leu Asn His Asp Ser Pro Pro Ser Thr
         105                 110                 115

 ccc ccc agg cgc ccg gac acc agc acc tcc aag atc tcg gtc act gtg      738
 Pro Pro Arg Arg Pro Asp Thr Ser Thr Ser Lys Ile Ser Val Thr Val
     120                 125                 130

 tcc aac aag atg gca gca aag agt gcc aag gcc act gca gcc ctg gcc      786
 Ser Asn Lys Met Ala Ala Lys Ser Ala Lys Ala Thr Ala Ala Leu Ala
 135                 140                 145                 150

 cgc cgg gag gag gag agc ctg gct gtt cct gcc aag cgg cgc cgg gtc      834
 Arg Arg Glu Glu Glu Ser Leu Ala Val Pro Ala Lys Arg Arg Arg Val
                 155                 160                 165

 act gct gag atg gag ggg aag tac gtc atc aac atg ccc aaa ggc acc      882
 Thr Ala Glu Met Glu Gly Lys Tyr Val Ile Asn Met Pro Lys Gly Thr
             170                 175                 180

 aca ccc cgc acc cgc aag atc ctg gag cag cag cag gct gca aaa ggt      930
 Thr Pro Arg Thr Arg Lys Ile Leu Glu Gln Gln Gln Ala Ala Lys Gly
         185                 190                 195

 ctc cat agg acg tct gtg ttt gac cgc ctc ggc gcc gag acc aag gca      978
 Leu His Arg Thr Ser Val Phe Asp Arg Leu Gly Ala Glu Thr Lys Ala
     200                 205                 210

 gac acc acg aca ggg agt aaa ccc aca gga gtc ttc agc cgc ctg ggg     1026
 Asp Thr Thr Thr Gly Ser Lys Pro Thr Gly Val Phe Ser Arg Leu Gly
 215                 220                 225                 230

 gcc acc cca gaa acg gac gag gat ctg gct tgg gac agc gac aat gac     1074
 Ala Thr Pro Glu Thr Asp Glu Asp Leu Ala Trp Asp Ser Asp Asn Asp
                 235                 240                 245

 agc agc agc tct gtc ttg cag tat gcc ggg gtc ctg aag aag cta gga     1122
 Ser Ser Ser Ser Val Leu Gln Tyr Ala Gly Val Leu Lys Lys Leu Gly
             250                 255                 260

 cgg ggc cca gcc aag gcc agt ccc cag cca gca ctg act gtc aaa gcc     1170
 Arg Gly Pro Ala Lys Ala Ser Pro Gln Pro Ala Leu Thr Val Lys Ala
         265                 270                 275

 aag gcc aca agc tca gcg aca acg gct gct gcc ccg aca ctg cgg cgc     1218
 Lys Ala Thr Ser Ser Ala Thr Thr Ala Ala Ala Pro Thr Leu Arg Arg
     280                 285                 290

 ctg gcg ctt tcc tca cgg tct ggg ctt gag agg aag ccg gag tcc ttg     1266
 Leu Ala Leu Ser Ser Arg Ser Gly Leu Glu Arg Lys Pro Glu Ser Leu
 295                 300                 305                 310

 tct aaa gtc agc atc atc aag aga ctg ggc gca gct gcc ctt gtg ccc     1314
 Ser Lys Val Ser Ile Ile Lys Arg Leu Gly Ala Ala Ala Leu Val Pro
                 315                 320                 325

 gag gcc cag gac agc cag gtc acc agc acc aag agt aag tcc tca gcc     1362
 Glu Ala Gln Asp Ser Gln Val Thr Ser Thr Lys Ser Lys Ser Ser Ala
             330                 335                 340

 gag gtc aag gtc acc att aag agg act ctg gtg ggg ccc cgg ggg agc     1410
 Glu Val Lys Val Thr Ile Lys Arg Thr Leu Val Gly Pro Arg Gly Ser
         345                 350                 355

 agc tcc agc gag ggc ctt ggt gcc cag atg gac cac gcg ggc act gtg     1458
 Ser Ser Ser Glu Gly Leu Gly Ala Gln Met Asp His Ala Gly Thr Val
     360                 365                 370

 agc gtg ttc aaa aga ctg ggc cgc agg acc ttc tag ccca cctgtgggcg     1508
 Ser Val Phe Lys Arg Leu Gly Arg Arg Thr Phe 
 375                 380                 385

 gggtgcaggc agcagagcct gcgggcatct gcctggccgc cccaggctcc tggcttcatc   1568

 acgcctccca ccagctcctg gatgacacag cttgtctccc tcgggctcta gagctaggcc   1628

 cgagcattcg c                                                        1639




      <210> 80
      <211> 12279
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (8405)..(12226)

      <400> 80
 atgtcgggcc ctcgcgccgg cttctaccgg caggagctga acaagaccgt gtgggaggtg     60

 ccgcagcggc tgcaggggct gcgcccggtg ggctccggcg cctacggctc cgtctgttcg    120

 gcctacgacg cccggctgcg ccagaaggtg gcggtgaaga agctgtcgcg ccccttccag    180

 tcgctgatcc acgcgcgcag aacgtaccgg gagctgcggc tgctcaagca cctgaagcac    240

 gagaacgtca tcgggcttct ggacgtcttc acgccggcca cgtccatcga ggacttcagc    300

 gaagtgtact tggtgaccac cctgatgggc gccgacctga acaacatcgt caagtgccag    360

 gcgctgagcg acgagcacgt tcaattcctg gtttaccagc tgctgcgcgg gctgaagtac    420

 atccactcgg ccgggatcat ccaccgggac ctgaagccca gcaacgtggc tgtgaacgag    480

 gactgtgagc tcagggtgag gcccgtgggc aggggtgggc agggcggcgg cggagcccgt    540

 gcggagcttg agaacaccac gtggtcgccc cagatcctgg attttgggct ggcgcgccag    600

 gcggacgagg agatgaccgg ctatgtggcc acgcgctggt accgggcacc tgagatcatg    660

 ctcaactgga tgcattacaa ccaaacagtg gatatctggt ccgtgggctg catcatggct    720

 gagctgctcc agggcaaggc cctcttcccg ggaagcgact gtatccttgg cccaggagag    780

 cgggctctgg gcagcgcccc aaagttttgg gtctgggggc ccaggagggg tctgtggctg    840

 gcccgtgggt gtttcctgag tgacacagac attgaccagc tgaagcgcat catggaagtg    900

 gtgggcacac ccagccctga ggttctggca aaaatctcct cagaacacgc ccggacatat    960

 atccagtccc tgccccccat gccccagaag gacctgagca gcatcttccg tggagccaac   1020

 cccctggcca tagacctcct tggaaggatg ctggtgctgg acagtgacca gagggtcagt   1080

 gcagctgagg cactggccca cgcctacttc agccagtacc acgaccccga ggatgagcca   1140

 gaggccgagc catatgatga gagcgttgag gccaaggagc gcacgctgga ggagtggaag   1200

 gagctcactt accaggaagt cctcagcttc aagcccccag agccaccgaa gccacctggc   1260

 agcctggaga ttgagcagct ccggccctcc ccaggctccg gccctccccc ggcggcggcc   1320

 gcctcgggtt tccggagggg ccggagggcg ggcgagggcg tcacgtgcgc gccgcccgcg   1380

 ggccgtggct tttaccgcca ggaggtgacc aagacggcct gggaggtgcg cgccgtgtac   1440

 cgggacctgc agcccgtggg ctcgggcgcc tacggcgcgg tgtgctcggc cgtggacggc   1500

 cgcaccggcg ctaaggtggc catcaagaag ctgtatcggc ctttccagtc cgagctgttc   1560

 gccaagcgcg cctaccgcga gctgcgcctg ctcaagcaca tgcgccacga gaacgtgatc   1620

 gggctgctgg acgtattcac tcctgatgag accctggatg acttcacgga cttttacctg   1680

 gtgatgccgt tcatgggcac cgacctgggc aagctcatga aacatgagaa gctaggcgag   1740

 gaccggatcc agttcctcgt gtaccagatg ctgaaggggc tgaggtatat ccacgctgcc   1800

 ggcatcatcc acagagacct gaagcccggc aacctggctg tgaacgaaga ctgtgagctg   1860

 aagatcctgg acttcggcct ggccaggcag gcagacagtg agatgactgg gtacgtggtg   1920

 acccggtggt accgggctcc cgaggtcatc ttgaattgga tgcgctacac gcagacggtg   1980

 gacatctggt ctgtgggctg catcatggcg gagatgatca caggcaagac gctgttcaag   2040

 ggcagcgacc gtatcctcca gccgcagggc ggcaccaggg gcggctgtgt tcctgacctc   2100

 ggtgcagacc tggaccagct gaaggagatc atgaaggtga cggggacgcc tccggctgag   2160

 tttgtgcagc ggctgcagag cgatgaggcc aagaactaca tgaagggcct ccccgaattg   2220

 gagaagaagg attttgcctc tatcctgacc aatgcaagcc ctctggctgt gaacctcctg   2280

 gagaagatgc tggtgctgga cgcggagcag cgggtgacgg caggcgaggc gctggcccat   2340

 ccctacttcg agtccctgca cgacacggaa gatgagcccc aggtccagaa gtatgatgac   2400

 tcctttgacg acgttgaccg cacactggat gaatggaagc ggcatccggg cctgggggac   2460

 gtgatcgcca tcagttccgg agccacgctg acttgtggca tggctgctgt ccacactggg   2520

 cccaaagtgt gggcccatag gtggcctgag gactgggggc cccaaaattc tgtgacccag   2580

 ctggatgtga actcccgcgg gggcagggtc ttcctgcgcc cgggccgggt gggccttggg   2640

 gctgcgctgg accctgaccc agctggtgca gaacggggct ctcatgggca ggctcggcca   2700

 cgggcgttcg gccccgagtg cgagatcgag cgtcctgagc gcctgaccgc agccctggat   2760

 cgcctgcggc agcgcggcct ggaacagagg tgtctgcggt tgtcagcccg cgaggcctcg   2820

 gaagaggagc tgggcctggt gcacagccca gagtatgtat ccctggtcag ggagacccag   2880

 gtcctaggca aggaggagct gcaggcgctg tccggacagt tcgacgccat ctacttccac   2940

 ccgagtacct ttcactgcgc gcggctggcc gcaggggctg gactgcagct ggtggacgct   3000

 gtgctcactg gagctgtgca aaatgggctt gccctggtga ggcctcccgg gcaccatggc   3060

 cagagggcgg ctgccaacgg gttctgtgtg ttcaacaacg tggccatagc agctgcacat   3120

 gccaagcaga aacacgggct acacaggatc ctcgtcgtgg actgggatgt gcaccatggc   3180

 caggggatcc agtatctctt tgaggatgac cccagcgtcc tttacttctc ctggcaccgc   3240

 tatgagcatg ggcgcttctg gcctttcctg cgagagtcag atgcagacgc agtggggcgg   3300

 ggacagggcc tcggcttcac tgtcaacctg ccctggaacc aggtgcccac cctcaagccc   3360

 cagtttgacc ctgagctggt gctggtctcg gcaggatttg actcagccat cggggaccct   3420

 gaggggcaaa tgcaggccac gccagagtgc ttcgcccacc tcacacagct gctgcaggtg   3480

 ctggccggcg gccgggtctg tgccgtgctg gagggcggct accacctgga gtcactggcg   3540

 gagtcagtgt gcatgacagt acagacgctg ctgggtgacc cggccccacc cctgtcaggg   3600

 ccaatggcgc catgtcagag gtgcgagggg agtgccctag agtccatcca gagtgcccgt   3660

 gctgcccagg ccccgcactg gaagagcctc cagcagcaag atgtgaccgc tgtgccgatg   3720

 agccccagca gccactcccc agaggggagg cctccacctc tgctgcctgg gggtccagtg   3780

 tgtaaggcag ctgcatctgc accgagctcc ctcctggacc agccgtgcct ctgccccgca   3840

 ccctctgtcc gcaccgctgt tgccctgaca acgccggata tcacattggt tctgccccct   3900

 gacgtcatcc aacaggaagc gtcagccctg agggaggaga cagaagcctg ggccaggcca   3960

 cacgagtccc tggcccggga ggaggccctc actgcacttg ggaagctcct gtacctctta   4020

 gatgggatgc tggatgggca ggtgaacagt ggtatagcag ccactccagc ctctgctgca   4080

 gcagccaccc tggatgtggc tgttcggaga ggcctgtccc acggagccca gagctggggt   4140

 gtgggagaag ggctgctgga ggcaatgcca ggtgggtctc cagcacagag gctcagcagt   4200

 cacagcaccc ctgcccatgg ccccgtgaat gctcttccac ctctgcctct gcggtttggg   4260

 ctcaggagga tgaccggtgg tttcctgagc tgcatcttgg gcttggtgct gcccctggcc   4320

 tatggcttcc agcctgacct ggtgctggtg gcgctggggc ctggccatgg cctgcagggc   4380

 ccccacgctg cactcctggc tgcaatgctt cgggggctgg cagggggccg agtcctggcc   4440

 ctcctggagg agaactccac accccagcta gcagggatcc tggcccgggt gctgaatgga   4500

 gaggcacctc ctagcctagg cccttcctct gtggcctccc cagaggacgt ccaggccctg   4560

 atgtacctga gagggcagct ggagcctcag tggaagatgt tgcaggccca tgcaacccac   4620

 gctcggtccc gttccggccc ctgcgccccg ctgcgcttcg ctccccgccc ttgcgccgtt   4680

 agtaaacatc gctcaaacga aacgctggct ctgcctcctt tactgagcac gctcggcctc   4740

 ggtctctcac ccgcggtgcc ggactcaggc cggaagtatg ccgcggccca ggcctcacca   4800

 acttcacgcg ctgccggcgt tcccgtgacg tatttccggc gcgcccgccc tagtgctctt   4860

 cacactggcg cggctgtgac gcgacggagg cggcgagagc ggcagccgtg ggcactttcc   4920

 acgggtgagg cctggagaac gggtggacgt gcaggccaga acccgggacc cacccggctg   4980

 agcccccaga ctctccgctg cccacgaccc tcggagtggc accctctcct ggccgtctcc   5040

 tctcgtgggt cccgaagaac gggtgcaaag ccgagttcgt ccgctgtact gcgcgggcgc   5100

 gcgtttcgtt cttcggtttt gccacggttc tgtgactccc taaaggttga gggctactga   5160

 attagaagaa acgccgagct ggcttctggt gggctgccgg gcgccgggca gcgtgcttgg   5220

 actggggagg gcagggcgtg tttactctga gtagagcaac cgcaagacct cctttaaaaa   5280

 ataccagttc tgagcttcgg cattggagag gccgcctgtc attcagcctc ttcggaccct   5340

 ctctcactcc ctgtcttccg gagcgtgagt gaagcccggg tgaggtgttt tcccacacgc   5400

 cgggggcccg gagctgagaa ggggcatggc cagcatcacg cagctgttcg acgacctgtg   5460

 tgaggccctc ctgccggctg ccaagactca cctgggccag cgcagtgtga accggaagag   5520

 ggcaaagcgg agcctcaaga aggtggccta caatgctctt ttcacaaatc tttttcaaga   5580

 tgagactcaa cagctgcagc ctgacatgtc aaaactacca gcgagaaaca agatcctcat   5640

 gttgtccttt gacttgagag tgggtggcct gggccccaag gccgaccgtt tggaggagct   5700

 tgtggaggag ctggaagcag ccccttgctg tccgcttttg gaggtggggt ctgttttgga   5760

 cctcctggtt cagctggcag ggagtggtcc ccctcaagtt ctgccgagaa aacgagacta   5820

 cttccttaac aacaagcatg tggggagaaa cgttccgtac agcggctatg attgcgacga   5880

 cctgagtgtg tttgagatgg acgttcagtc tctgatctcc agagaagagt gtttgtgtca   5940

 cagcatgatc caggaaacac ttcaggttat ggaggctgct ccaggcactg gcctgcccac   6000

 cgtcgggctc ttctcatttg gtgacccttg tggtgacagg ttcgagagag acacccgggt   6060

 ctcgctcttc ggggcccttg tgcacagccg cacttatgac atggacgtcc gactgggcct   6120

 gccccccgtg ccagacaatg cggacctctc tgggctggct attaaggtcc caccgagtgt   6180

 ggatcagtgg gaagacgaag gattccagtc agcgtccaac ttgactcctg attcccagtc   6240

 tgagcccagc gtgaccccag acgtggacct gtgggaagcc gcacttacct atgaggccag   6300

 caagcggagg tgctgggagc gagttggctg gctgaatgat gggcaggggt ctgcacggac   6360

 ggtctgtgtt tatcctcctc tgttgggggc tcaggctcct ctccccctgg ctgttgtgga   6420

 tgttgttgcc gtggacgggg gtgtggatgc tgctgtggac aggcatgtgg atgttgccgt   6480

 ggacaggcat gtggataggc atgtggatgt tgccgtggac agggatgtgg atgctgccat   6540

 ggacaggagt gtggatgatg ctgccgtgga cagggatgtg gatgatgctg ccgtgaatag   6600

 gggtgtagat gctgccatgg actggggtgt ggatgctgcc atggacacgg gtgtggatga   6660

 tgctgcagtg gatagggttg tggatgatgt tcccatggac aggggtgtgg atactgctgt   6720

 ggacaggggt gtggctgatg ctgccgtgga cagggggggt gtggatgatg ctgcggtgga   6780

 cctgggtgtg gatgctgcca tggacgggag tgtgggcgat gctgccgtgg acctgggtgt   6840

 ggatgctgct gtggacaggg gtgtggatga tgctgccatg gggggtgtgg atgatgctgc   6900

 tgtggacctg gatgtggatg ctgctgtgga cgggggtgtg ggtgctggta ccatgggggg   6960

 tgtggatgat gctgctgtgg acctgggtgt agatgctgct gtggacgggg ggggtgtgga   7020

 tgatgctgct gtggataggg gtgtggatga tgctgccgtg gacgggggtg tgggcgatgc   7080

 tgccgtggac ctgggtgtgg atgatgctgc tgtggaactg ggtgtggatg ctgctgtgga   7140

 caggggtgtg gatgctgctg ctgtggacgg gggtgtgggc gatgctgctg tggacctgga   7200

 tgtggatgat gctgccgtgg acttgggtgt ggatgctgct gtggacaggg gtgtggatga   7260

 tgctgccgtg gacctgggtg tggatgctgc tgtggacagg ggtgtggatg ctgctgtgga   7320

 caggggtgtg gatgatgctg ccatggaggg tgtggatgat gctgctgtgg acctgggtgt   7380

 agatgctgct gtggacgggc gtgtggatga tgctgccgtg gatgggtggg gtgtggatgc   7440

 tgccatggat ggggtatgga tgatgctgcc atggacaggg ggtgtggatg atgctgcagt   7500

 ggacctggat gtggatgctg ctgtggacag gggtgtggat gatgctgcca tgaacaggga   7560

 tgtggatgct gccatggacc tgggtgtgga tgctgccatg gacaggggct gggccagtcg   7620

 gatacccccg gccatgccca ggaccccagg aagcccccct ggccacagag aggagcctta   7680

 cctgacggag gcgggaaggg acgctttcga caagttctgc aggctccacc aaggggagct   7740

 ccagctgctt gctgggggcg tcctacaggc cccgcagccc gtgctggtga aggagtgcga   7800

 gctggtgaaa gacgtgctga acgtcttgat tggggtcgtg tctgccacgt tttcgctctg   7860

 ccagccggcc caggcctttg tggtgaagcg gggcgtccac gtgtcaggag cgtctcccga   7920

 gagcatcagc agcctgctct cggaagtggc cgagtatggg acctgctaca cgcgcctgag   7980

 tcatttctct ctgcagcccg tcctggactc tttgtacagc aagggcctcg tgttccaggc   8040

 cttcaccagt ggcctgagga ggtacctgca gtattaccgg gcctgcgtcc tttccactcc   8100

 gcccaccctg agcctcctca ccattggttt tctcttcaag aaacttggcc ggcagctcag   8160

 gtacctggcc gagctctgtg gcgttggcgc tgtgctcccg ggcacctgtg gaggaggccc   8220

 cagggccgcg tttcccaccg gcgtgaagct gctgtcctac ctctaccagg aggctctgca   8280

 caactgcagc aacgagcact accctgtact gctgtccctg ctgaagacca gctgcgagcc   8340

 ctacacccgg ttcatccacg actgggtgta cagcggggtg ttcagagacg cttatggcga   8400

 gttc atg att cag gtg aac cac gag tac ctc agc ttc cga gat aag ttg    8449
      Met Ile Gln Val Asn His Glu Tyr Leu Ser Phe Arg Asp Lys Leu
        1               5                  10                  15

 tac tgg aca cat ggc tac gtg ctc atc tcc aaa gag gtg gag gac tgt     8497
 Tyr Trp Thr His Gly Tyr Val Leu Ile Ser Lys Glu Val Glu Asp Cys
                  20                  25                  30

 gtt ccc gtg ttt ctg aag cac att gcc cac gac ata tac gtc tgc gga     8545
 Val Pro Val Phe Leu Lys His Ile Ala His Asp Ile Tyr Val Cys Gly
              35                  40                  45

 aag acc att aac ctg ctg aag ctc tgc tgc ccc cgg cat tac ctc tgt     8593
 Lys Thr Ile Asn Leu Leu Lys Leu Cys Cys Pro Arg His Tyr Leu Cys
          50                  55                  60

 tgg tcc gac gtc cct gtc ccc cgg atc tcg gtg att ttc tcc ctt gag     8641
 Trp Ser Asp Val Pro Val Pro Arg Ile Ser Val Ile Phe Ser Leu Glu
      65                  70                  75

 gag ttg aag gag att gag aag gac tgt gcc gtc tac gtt ggg cgc atg     8689
 Glu Leu Lys Glu Ile Glu Lys Asp Cys Ala Val Tyr Val Gly Arg Met
  80                  85                  90                  95

 gag agg gtg gcc cgc cac agc tct gtc agc aag gag gag aag gaa tta     8737
 Glu Arg Val Ala Arg His Ser Ser Val Ser Lys Glu Glu Lys Glu Leu
                 100                 105                 110

 cgt atg gaa att gca aaa caa gaa tta atc gct cat gcc cgg gaa gca     8785
 Arg Met Glu Ile Ala Lys Gln Glu Leu Ile Ala His Ala Arg Glu Ala
             115                 120                 125

 gca tcc agg gtc ctg agt gca ctg agt gac cgg cag atg tca gaa cgg     8833
 Ala Ser Arg Val Leu Ser Ala Leu Ser Asp Arg Gln Met Ser Glu Arg
         130                 135                 140

 atg gcc ttg gat gcc cgg aag cgt gag cag ttt cag agg ctg aaa gaa     8881
 Met Ala Leu Asp Ala Arg Lys Arg Glu Gln Phe Gln Arg Leu Lys Glu
     145                 150                 155

 caa ttt gtg aag gac cag gag cga cgc cag gcg gcc agg cag gag gag     8929
 Gln Phe Val Lys Asp Gln Glu Arg Arg Gln Ala Ala Arg Gln Glu Glu
 160                 165                 170                 175

 ctg gat gat gac ttc agc tac gcc cgt gaa ctc cga gac agg gag aga     8977
 Leu Asp Asp Asp Phe Ser Tyr Ala Arg Glu Leu Arg Asp Arg Glu Arg
                 180                 185                 190

 agg ctg aag tcc ctg gag gag gag ctg gag agg aag gcg agg cag gca     9025
 Arg Leu Lys Ser Leu Glu Glu Glu Leu Glu Arg Lys Ala Arg Gln Ala
             195                 200                 205

 ctg gtc gac cac tac agc aag ctc tct gca gag gca gct cgt cgg gag     9073
 Leu Val Asp His Tyr Ser Lys Leu Ser Ala Glu Ala Ala Arg Arg Glu
         210                 215                 220

 cag aag gca ctg tgg aga atc cag agg cac cga ctg gag agt gca cgg     9121
 Gln Lys Ala Leu Trp Arg Ile Gln Arg His Arg Leu Glu Ser Ala Arg
     225                 230                 235

 ctt cgt ttt ctc tta gaa gat gag aaa cac att cag gag atg ctg aaa     9169
 Leu Arg Phe Leu Leu Glu Asp Glu Lys His Ile Gln Glu Met Leu Lys
 240                 245                 250                 255

 gca gtg tct gag gct cac cag ccc cag gag ccg cca gac gtc ctc ttg     9217
 Ala Val Ser Glu Ala His Gln Pro Gln Glu Pro Pro Asp Val Leu Leu
                 260                 265                 270

 agc gtg cac ccc cag gtc acg tct ccg ggc cct gag cac cca gag gga     9265
 Ser Val His Pro Gln Val Thr Ser Pro Gly Pro Glu His Pro Glu Gly
             275                 280                 285

 ggc caa ggc tgt gat tct ggg tct gca gag caa cac tcg cct gcc tgg     9313
 Gly Gln Gly Cys Asp Ser Gly Ser Ala Glu Gln His Ser Pro Ala Trp
         290                 295                 300

 gat ggc tgg aac agg cca ggc ctg ctg acc cca cag ccc ctt aag cct     9361
 Asp Gly Trp Asn Arg Pro Gly Leu Leu Thr Pro Gln Pro Leu Lys Pro
     305                 310                 315

 cta gca gtg ggg gct ggt ggc agg ggg ctg cag cag gcg gag ggg gcc     9409
 Leu Ala Val Gly Ala Gly Gly Arg Gly Leu Gln Gln Ala Glu Gly Ala
 320                 325                 330                 335

 aga ccc ttc tct gac agc ctc agc att gga gac ttc cta cct gtg ggc     9457
 Arg Pro Phe Ser Asp Ser Leu Ser Ile Gly Asp Phe Leu Pro Val Gly
                 340                 345                 350

 cca ggg gct gag ccg tcc gtg cag act ggc atg gtc cct ctc ctg gag     9505
 Pro Gly Ala Glu Pro Ser Val Gln Thr Gly Met Val Pro Leu Leu Glu
             355                 360                 365

 gtg gcg ctg cag acc att aac ttg gac ctg ccc ccc tca gct cct ggg     9553
 Val Ala Leu Gln Thr Ile Asn Leu Asp Leu Pro Pro Ser Ala Pro Gly
         370                 375                 380

 gag gca ccc gca gca gcc agc act cag ccc tcc agg cca cag gag tac     9601
 Glu Ala Pro Ala Ala Ala Ser Thr Gln Pro Ser Arg Pro Gln Glu Tyr
     385                 390                 395

 gac ttt agt act gtc ctg agg cca gct gtg gcc acc tca cct gca cca     9649
 Asp Phe Ser Thr Val Leu Arg Pro Ala Val Ala Thr Ser Pro Ala Pro
 400                 405                 410                 415

 ggg ccc ctg cag gct gca gag tgc agc ttg ggc agc tca ggg cta cag     9697
 Gly Pro Leu Gln Ala Ala Glu Cys Ser Leu Gly Ser Ser Gly Leu Gln
                 420                 425                 430

 ctg tgg gag gac agt tgt ggg aag atg gat gcc tgt ggc tcc gcc tcg     9745
 Leu Trp Glu Asp Ser Cys Gly Lys Met Asp Ala Cys Gly Ser Ala Ser
             435                 440                 445

 cgg gag act ctg ctc ccc tca cac cca ccc agg cgt gct gct ctg gag     9793
 Arg Glu Thr Leu Leu Pro Ser His Pro Pro Arg Arg Ala Ala Leu Glu
         450                 455                 460

 gag ggg agc agc cag ccc aca gag cgg ctc ttt ggg cag gtg tca ggg     9841
 Glu Gly Ser Ser Gln Pro Thr Glu Arg Leu Phe Gly Gln Val Ser Gly
     465                 470                 475

 ggt ggt ctt ccc aca ggg gac tac gct tct gaa ata gct ccc acc cgg     9889
 Gly Gly Leu Pro Thr Gly Asp Tyr Ala Ser Glu Ile Ala Pro Thr Arg
 480                 485                 490                 495

 cca cgg tgg aac acc cac ggg cac gtg tct gac gcc agc atc agg gtc     9937
 Pro Arg Trp Asn Thr His Gly His Val Ser Asp Ala Ser Ile Arg Val
                 500                 505                 510

 ggg gag aat gtg tca gat gtg gct ccc acc cag cca cgg tgg aac acc     9985
 Gly Glu Asn Val Ser Asp Val Ala Pro Thr Gln Pro Arg Trp Asn Thr
             515                 520                 525

 cac gga cac gta tcc aat gcc agc atc agc tta ggg gag tct gtg tca    10033
 His Gly His Val Ser Asn Ala Ser Ile Ser Leu Gly Glu Ser Val Ser
         530                 535                 540

 gat gtg gct ccc act cgg cca cgg tgg aac atc cat gga cat gtg tcc    10081
 Asp Val Ala Pro Thr Arg Pro Arg Trp Asn Ile His Gly His Val Ser
     545                 550                 555

 aac gcc agc atc agg gtc ggg gag aat gtg tca gat gtg gct ccc acc    10129
 Asn Ala Ser Ile Arg Val Gly Glu Asn Val Ser Asp Val Ala Pro Thr
 560                 565                 570                 575

 agg cca cgg tgg aat acc cac ggg cac gtg tcc aac gcc agc atc agg    10177
 Arg Pro Arg Trp Asn Thr His Gly His Val Ser Asn Ala Ser Ile Arg
                 580                 585                 590

 gtt ggg gag aac gtg tcg gac gtg gct ccc acc cgg cca cgg tgg aac    10225
 Val Gly Glu Asn Val Ser Asp Val Ala Pro Thr Arg Pro Arg Trp Asn
             595                 600                 605

 acc cat gga cac gtg tcc gat gcc agc atc agc ttg ggg gag tct gtg    10273
 Thr His Gly His Val Ser Asp Ala Ser Ile Ser Leu Gly Glu Ser Val
         610                 615                 620

 tca gac atg gct ccc gcc cgg cca cgg tgg aac acc cat gga cac gtg    10321
 Ser Asp Met Ala Pro Ala Arg Pro Arg Trp Asn Thr His Gly His Val
     625                 630                 635

 tct gat gcc agc atc agc ttg ggg gag tct gtg tca gac atg gct ccc    10369
 Ser Asp Ala Ser Ile Ser Leu Gly Glu Ser Val Ser Asp Met Ala Pro
 640                 645                 650                 655

 acc cgg cca cgg tgg aac acc cac gga cat gtg tct gac acc agc atc    10417
 Thr Arg Pro Arg Trp Asn Thr His Gly His Val Ser Asp Thr Ser Ile
                 660                 665                 670

 agg gtt ggg gag aac gta tcg gac gtg gct ccc atc cgg tca cgg tgc    10465
 Arg Val Gly Glu Asn Val Ser Asp Val Ala Pro Ile Arg Ser Arg Cys
             675                 680                 685

 aac acc cat gga cac gtg tcc gac gcc agc atc agc ttg ggg gag cct    10513
 Asn Thr His Gly His Val Ser Asp Ala Ser Ile Ser Leu Gly Glu Pro
         690                 695                 700

 gtg tcg gat gtg gtt tcc acc cgg cca cgg tgg aac acc cat gta ccc    10561
 Val Ser Asp Val Val Ser Thr Arg Pro Arg Trp Asn Thr His Val Pro
     705                 710                 715

 atc cct ccg ccc cac atg gtg ctg ggg gct ctc tca cca gaa gct gag    10609
 Ile Pro Pro Pro His Met Val Leu Gly Ala Leu Ser Pro Glu Ala Glu
 720                 725                 730                 735

 ccc aac aca ccc agg ccc caa cag agc ccc cct ggc cac acg tcc cag    10657
 Pro Asn Thr Pro Arg Pro Gln Gln Ser Pro Pro Gly His Thr Ser Gln
                 740                 745                 750

 tca gcg ctc agc ctg gga gca cag agc act gtg ctg gac tgt ggg cca    10705
 Ser Ala Leu Ser Leu Gly Ala Gln Ser Thr Val Leu Asp Cys Gly Pro
             755                 760                 765

 cgg ctg cct gta gaa gtg ggg cca tct ctg tcc tcc ccc agc tcg ggc    10753
 Arg Leu Pro Val Glu Val Gly Pro Ser Leu Ser Ser Pro Ser Ser Gly
         770                 775                 780

 tgc ggg gag ggg agc atc agc gtg ggg gag aac gtg tca gac gtg gct    10801
 Cys Gly Glu Gly Ser Ile Ser Val Gly Glu Asn Val Ser Asp Val Ala
     785                 790                 795

 ccc acc caa cca tgg tgg ccc aac acc ccg gga gac agt gtc tct gaa    10849
 Pro Thr Gln Pro Trp Trp Pro Asn Thr Pro Gly Asp Ser Val Ser Glu
 800                 805                 810                 815

 gaa cta ggc cct ggg agg agc ggg gac act gag gac ctc tct cca aat    10897
 Glu Leu Gly Pro Gly Arg Ser Gly Asp Thr Glu Asp Leu Ser Pro Asn
                 820                 825                 830

 tgg cct ctc aac tca cag gaa gac aca gct gcc cag agc agc cca ggc    10945
 Trp Pro Leu Asn Ser Gln Glu Asp Thr Ala Ala Gln Ser Ser Pro Gly
             835                 840                 845

 cgt ggt gag gag gcg gag gca tcg gcg gcg gag gct cag ggt ggg gag    10993
 Arg Gly Glu Glu Ala Glu Ala Ser Ala Ala Glu Ala Gln Gly Gly Glu
         850                 855                 860

 cag gcc tac ctg gca ggc ctg gca ggg cag tac cac ttg gag cgg tac    11041
 Gln Ala Tyr Leu Ala Gly Leu Ala Gly Gln Tyr His Leu Glu Arg Tyr
     865                 870                 875

 ccg gac agt tac gag tcc atg tcc gag ccg ccc att gct cat ctt ttg    11089
 Pro Asp Ser Tyr Glu Ser Met Ser Glu Pro Pro Ile Ala His Leu Leu
 880                 885                 890                 895

 cgc ccc gtg ctt ccc cgg gcc ttc gcc ttc ccc gtg gac ccc cag gtc    11137
 Arg Pro Val Leu Pro Arg Ala Phe Ala Phe Pro Val Asp Pro Gln Val
                 900                 905                 910

 cag tct gcc gct gat gag act gct gtg cag ctg agc gag ttg ctg acg    11185
 Gln Ser Ala Ala Asp Glu Thr Ala Val Gln Leu Ser Glu Leu Leu Thr
             915                 920                 925

 ctg ccc gtg ctc atg aag cgc tcc atc acg gca ccg ctg gcc gcc cac    11233
 Leu Pro Val Leu Met Lys Arg Ser Ile Thr Ala Pro Leu Ala Ala His
         930                 935                 940

 atc tcc ttg gtg aac aag gcc gct gtc gac tac ttc ttc gtg gag ctg    11281
 Ile Ser Leu Val Asn Lys Ala Ala Val Asp Tyr Phe Phe Val Glu Leu
     945                 950                 955

 cac ctg gag gcg cac tat gag gca ctg cgg cac ttc ctg ctg atg gag    11329
 His Leu Glu Ala His Tyr Glu Ala Leu Arg His Phe Leu Leu Met Glu
 960                 965                 970                 975

 gac ggc gag ttc gcc cag tcc ctc agc gac ctg ctc ttt gag aag gtg    11377
 Asp Gly Glu Phe Ala Gln Ser Leu Ser Asp Leu Leu Phe Glu Lys Val
                 980                 985                 990

 gcc tcc gga cac ggg ctt gga gct ggg caa acg ccc gga gag ctg ctc    11425
 Ala Ser Gly His Gly Leu Gly Ala Gly Gln Thr Pro Gly Glu Leu Leu
             995                1000                1005

 aac ccg ctg gtg ctg aac tct gtg ctg agc aag gcc ctg cag tgc agc    11473
 Asn Pro Leu Val Leu Asn Ser Val Leu Ser Lys Ala Leu Gln Cys Ser
        1010                1015                1020

 ctg cat ggg gac acc ccg cac gcc tcc aac ctc tcc ctc gct ctc aag    11521
 Leu His Gly Asp Thr Pro His Ala Ser Asn Leu Ser Leu Ala Leu Lys
    1025                1030                1035

 tac ctg ccc gag gtg ttt gcc ccc aac gcc ccg gat gtg ctg agc tgc    11569
 Tyr Leu Pro Glu Val Phe Ala Pro Asn Ala Pro Asp Val Leu Ser Cys
1040                1045                1050                1055

 ctg gag ctc agg tac aag gtg gac tgg cct ctc aac att gtc atc acc    11617
 Leu Glu Leu Arg Tyr Lys Val Asp Trp Pro Leu Asn Ile Val Ile Thr
                1060                1065                1070

 gag ggc tgc ctg agc aag tac agc ggc gtc ttc tcc ttc ctg ctg cag    11665
 Glu Gly Cys Leu Ser Lys Tyr Ser Gly Val Phe Ser Phe Leu Leu Gln
            1075                1080                1085

 ctg aag ctc atg atg tgg gcg ctc aag gac gtc tgc ttc cac ctc aag    11713
 Leu Lys Leu Met Met Trp Ala Leu Lys Asp Val Cys Phe His Leu Lys
        1090                1095                1100

 cgc aca gcc ctg ctg agc cac atg gcc ggc tct gtg cag ttc cgt cag    11761
 Arg Thr Ala Leu Leu Ser His Met Ala Gly Ser Val Gln Phe Arg Gln
    1105                1110                1115

 ctg cag ctg ttc aag cac gag atg cag cat ttc gtg aag gtc atc cag    11809
 Leu Gln Leu Phe Lys His Glu Met Gln His Phe Val Lys Val Ile Gln
1120                1125                1130                1135

 ggc tac atc gcc aac cag atc ctg cac gtc acc tgg tgc gag ttc agg    11857
 Gly Tyr Ile Ala Asn Gln Ile Leu His Val Thr Trp Cys Glu Phe Arg
                1140                1145                1150

 gcc agg ttg gcc acc gtg ggc gac ctg gag gag atc cag cgt gcg cac    11905
 Ala Arg Leu Ala Thr Val Gly Asp Leu Glu Glu Ile Gln Arg Ala His
            1155                1160                1165

 gca gag tac ctg cac aag gcc gtc ttc agg ggc ctg ctc acg gag aag    11953
 Ala Glu Tyr Leu His Lys Ala Val Phe Arg Gly Leu Leu Thr Glu Lys
        1170                1175                1180

 gcg gcg ccc gtc atg aac gtc atc cac agc atc ttc agc ctc gtg ctc    12001
 Ala Ala Pro Val Met Asn Val Ile His Ser Ile Phe Ser Leu Val Leu
    1185                1190                1195

 aag ttc cgc agc cag ctc atc tcc cag gcc tgg ggg ccc cct ggg ggc    12049
 Lys Phe Arg Ser Gln Leu Ile Ser Gln Ala Trp Gly Pro Pro Gly Gly
1200                1205                1210                1215

 ccg cgg ggt gca gag cac ccc aac ttt gca ctc atg cag cag tcc tac    12097
 Pro Arg Gly Ala Glu His Pro Asn Phe Ala Leu Met Gln Gln Ser Tyr
                1220                1225                1230

 aac acc ttc aag tac tac tcc cac ttt ctc ttc aaa gtg gtg acc aag    12145
 Asn Thr Phe Lys Tyr Tyr Ser His Phe Leu Phe Lys Val Val Thr Lys
            1235                1240                1245

 ctg gtg aac cgc ggc tac cag ccc cac ctg gag gac ttt ctg ctg cgc    12193
 Leu Val Asn Arg Gly Tyr Gln Pro His Leu Glu Asp Phe Leu Leu Arg
        1250                1255                1260

 atc aac ttc aac aac tac tac cag gac gcc tga ggctgctc tgcgggggac    12244
 Ile Asn Phe Asn Asn Tyr Tyr Gln Asp Ala 
    1265                1270

 gtgcacaata aaggtgttct cggaaaaaaa aaaaa                             12279




      <210> 81
      <211> 965
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (689)..(883)

      <400> 81
 ctcagcacca tttaatgtat taaaaaacag ctttaaaaac aaaacaaaac aaaaaaaact     60

 tgaaatagga acttcaccgt ctcttaagag cgatatattt aatacattca caagattcga    120

 aatgaaaaac aaacattatt catgctacag gtttttaatt ttccttggac aacaccaaaa    180

 acacagtact caaacggcat gttttttttt tgtttttttg gtttcttttt gagatggaat    240

 ttcactcttg ttgcccaggc tggtcttgaa ctctgggctc aagcgatcct cctgcctcag    300

 cctccctaag tgctgggatt acaagcatga gccaccacac tcagccttca aaggtattta    360

 tcatctatgt ccattatact atataatagt tatttgtgtc ttcctccatt acattataat    420

 tttgacttcc tgtaattcac ctttgattct tcagcactta atagtctgcc tgggactaag    480

 tgctcaataa attctgaact caaatcacta acagcaaaag aaaaattaat gaccagctat    540

 ttaagacaga tatataggat gaaatttctc attacattat ttatgcattc cccttaattg    600

 tgtgcctaac acgtttaact gccttatttt atttttttac aaacagggtc tcactttgtc    660

 acccaccctg aggtgcagtg gtgtaact   atg gct cac tgc agc ctc aac ctc     712
                                  Met Ala His Cys Ser Leu Asn Leu
                                    1               5

 cca ggc tcg gat gat cct cct gcc tca gcc tcc caa gta gct agg aca      760
 Pro Gly Ser Asp Asp Pro Pro Ala Ser Ala Ser Gln Val Ala Arg Thr
      10                  15                  20

 aca ggt gca cgc cac cat gcc cag cta att ttt gta ttt ttt gta gag      808
 Thr Gly Ala Arg His His Ala Gln Leu Ile Phe Val Phe Phe Val Glu
  25                  30                  35                  40

 atg ggg ttt cac tat att tcc cag gct ggt ctt gaa ctc tgg gct caa      856
 Met Gly Phe His Tyr Ile Ser Gln Ala Gly Leu Glu Leu Trp Ala Gln
                  45                  50                  55

 gcg atc ctc ctg cct cag cct ccc taa gtgct gggattacag gtgtggggcc      908
 Ala Ile Leu Leu Pro Gln Pro Pro 
              60

 accgcacctt gacctgcctt atttttttag atcgaaaagc agagcagctt taaagag       965




      <210> 82
      <211> 593
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (12)..(434)

      <220>
      <221> misc_feature
      <222> (1)...(593)
      <223> n = a,t,c or g

      <400> 82
 cgggactcca a atg ggt cgc agt cgc agc cgc tct cca cgg agg gaa cgt      50
              Met Gly Arg Ser Arg Ser Arg Ser Pro Arg Arg Glu Arg
                1               5                  10

 agg cgt tcc cgg tcc aca tcc cgg gag aga gaa cgc agg cgc cga gaa       98
 Arg Arg Ser Arg Ser Thr Ser Arg Glu Arg Glu Arg Arg Arg Arg Glu
      15                  20                  25

 agg tcc agg tct cgg gag aga gat cgg aga agg agc cgc tcg cga tcc      146
 Arg Ser Arg Ser Arg Glu Arg Asp Arg Arg Arg Ser Arg Ser Arg Ser
  30                  35                  40                  45

 ccg cac cga aga cgc tcc cga tct cca aga cga cat aga tcc aca tct      194
 Pro His Arg Arg Arg Ser Arg Ser Pro Arg Arg His Arg Ser Thr Ser
                  50                  55                  60

 cct tcc cct tct cga ctg aaa gaa aga aga gat gag gaa aag aaa gaa      242
 Pro Ser Pro Ser Arg Leu Lys Glu Arg Arg Asp Glu Glu Lys Lys Glu
              65                  70                  75

 aca aaa gaa aca aag agc aaa gaa cgg cag att act gag gaa gac tta      290
 Thr Lys Glu Thr Lys Ser Lys Glu Arg Gln Ile Thr Glu Glu Asp Leu
          80                  85                  90

 gag ggc aaa aca gag gaa gaa ata gaa atg atg aag tta atg gga ttt      338
 Glu Gly Lys Thr Glu Glu Glu Ile Glu Met Met Lys Leu Met Gly Phe
      95                 100                 105

 gcc tcc ttt gac tcc aca aaa ggt aag aag gtg gat ggc tct gta aat      386
 Ala Ser Phe Asp Ser Thr Lys Gly Lys Lys Val Asp Gly Ser Val Asn
 110                 115                 120                 125

 gcc tat gcc ata aat gtc tct cag aag agg aag tac agg tat gca tag      434
 Ala Tyr Ala Ile Asn Val Ser Gln Lys Arg Lys Tyr Arg Tyr Ala 
                 130                 135                 140

 cccccattat tatgtttgaa ctaataaatc agttttttac ttcaaacttt attatgagat    494

 aatcatgttt gtaggaaatg tagcagtttt ccatactgtt ccttgtttgg aatggaaata    554

 ttncatttgc ttatattcct gggtgtgttc aaaattgtt                           593




      <210> 83
      <211> 533
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (411)..(506)

      <400> 83
 tactactact actaaattcg cggccggtcg acaaaacata agaaaataag agagttggaa     60

 agaaatctgg taaaacttat gcaaataaaa aatacagtca ttaaattttt aagaaatcag    120

 tgaatgggtt aaaggaggaa tgtgaatgga agctaaagga gaaataagtg agtggaagaa    180

 atatgtgaag aaattaccca gaatgcagga aagagagagg aaaaaaagaa aaaacaggaa    240

 atcttgagag acacagatgt tgaaatggga aggtctaact taatgtctaa tggaagttga    300

 caagagaaaa agcaatatgg agatgaagca atatttgaag agagaatggc tgaaaatact    360

 gaagaattaa tgaagggtag aagtccttag atttagaaag cctaggccag   atg tgg     416
                                                          Met Trp
                                                            1

 tgg ctc atg cct ata atc cca gca ctt ttg gag gcc gag gcg aga gga      464
 Trp Leu Met Pro Ile Ile Pro Ala Leu Leu Glu Ala Glu Ala Arg Gly
           5                  10                  15

 ttg ctt gag gcc agg aat ttg aga caa gcc tgg gca aca tag cgagacc      513
 Leu Leu Glu Ala Arg Asn Leu Arg Gln Ala Trp Ala Thr 
      20                  25                  30

 tcatctctat aaaaaaaaaa                                                533




      <210> 84
      <211> 1913
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (70)..(1758)

      <400> 84
 cttatctttc tgaagcacag agaagcggtt atacgcagaa gtttgggaga actgggtaag     60

 gccgcacac    atg gaa att gcc agt ttc gtg ggt ccc aac gtc aat act     108
              Met Glu Ile Ala Ser Phe Val Gly Pro Asn Val Asn Thr
                1               5                  10

 gtg ggc aac ctt aga ccg gct caa agc gca gct ggg gac ggt gat gaa      156
 Val Gly Asn Leu Arg Pro Ala Gln Ser Ala Ala Gly Asp Gly Asp Glu
      15                  20                  25

 gtg cag agc gtc cac agc cag cga caa gac tgc caa gca act ggc agc      204
 Val Gln Ser Val His Ser Gln Arg Gln Asp Cys Gln Ala Thr Gly Ser
  30                  35                  40                  45

 ctg agt aac gga gaa aac aac gaa aaa aac gca ttc acc acc tac caa      252
 Leu Ser Asn Gly Glu Asn Asn Glu Lys Asn Ala Phe Thr Thr Tyr Gln
                  50                  55                  60

 caa gaa aca aaa aac acg acc acc cca cag tca gtc tac ttt tta ggc      300
 Gln Glu Thr Lys Asn Thr Thr Thr Pro Gln Ser Val Tyr Phe Leu Gly
              65                  70                  75

 gtg aat aag atg agc agc cag cac cgc gaa ggc tca cgg gga acg tcc      348
 Val Asn Lys Met Ser Ser Gln His Arg Glu Gly Ser Arg Gly Thr Ser
          80                  85                  90

 ccg ccc ctt ccg gtt ctt gcc tgc ttt gag ctg gct gtc gcg aga gtt      396
 Pro Pro Leu Pro Val Leu Ala Cys Phe Glu Leu Ala Val Ala Arg Val
      95                 100                 105

 ggt ccg cgg acg ccg gaa gta gtt cgt cgc tcc cta gcg gcc gaa ggg      444
 Gly Pro Arg Thr Pro Glu Val Val Arg Arg Ser Leu Ala Ala Glu Gly
 110                 115                 120                 125

 gcg ggc tcg cgg ggt ctc gac tgc ttt cgg ctt gct cgg cgg agc aag      492
 Ala Gly Ser Arg Gly Leu Asp Cys Phe Arg Leu Ala Arg Arg Ser Lys
                 130                 135                 140

 atg gcg gac atc tcc ctg gac gaa ctc atc agg aag cgc ggg gcg gcg      540
 Met Ala Asp Ile Ser Leu Asp Glu Leu Ile Arg Lys Arg Gly Ala Ala
             145                 150                 155

 gcg aaa gga cgg ctt aat gcc aga ccg gga gtt gga ggt gtc cga tct      588
 Ala Lys Gly Arg Leu Asn Ala Arg Pro Gly Val Gly Gly Val Arg Ser
         160                 165                 170

 cga gtt ggg atc cag caa ggc ctt ctc agc cag tca aca cgc aca gcc      636
 Arg Val Gly Ile Gln Gln Gly Leu Leu Ser Gln Ser Thr Arg Thr Ala
     175                 180                 185

 acc ttc cag cag aga ttt gat gcc cgg cag aag att ggc ctc tca gat      684
 Thr Phe Gln Gln Arg Phe Asp Ala Arg Gln Lys Ile Gly Leu Ser Asp
 190                 195                 200                 205

 gcc cgg ctc aaa ctg gga gtc aag gat gcc cgg gag aag ctt ttg cag      732
 Ala Arg Leu Lys Leu Gly Val Lys Asp Ala Arg Glu Lys Leu Leu Gln
                 210                 215                 220

 aaa gat gcc cga ttt cga atc aaa ggg aaa gtg cag gat gcc aga gag      780
 Lys Asp Ala Arg Phe Arg Ile Lys Gly Lys Val Gln Asp Ala Arg Glu
             225                 230                 235

 atg ttg aac tct cgc aag cag cag acc acg gtg ccc cag aag ccc cgc      828
 Met Leu Asn Ser Arg Lys Gln Gln Thr Thr Val Pro Gln Lys Pro Arg
         240                 245                 250

 cag gtt gct gat gcc cgg gag aag atc agc ttg aag agg agt tcc cct      876
 Gln Val Ala Asp Ala Arg Glu Lys Ile Ser Leu Lys Arg Ser Ser Pro
     255                 260                 265

 gct gcc ttc ata aac cca ccc att ggg aca gtg acc cct gct ctg aag      924
 Ala Ala Phe Ile Asn Pro Pro Ile Gly Thr Val Thr Pro Ala Leu Lys
 270                 275                 280                 285

 ctc acc aaa acc atc cag gtt cca cag cag aaa gcc atg gca cca ctt      972
 Leu Thr Lys Thr Ile Gln Val Pro Gln Gln Lys Ala Met Ala Pro Leu
                 290                 295                 300

 cat ccc cat cct gcc gga atg aga atc aat gtt gtc aat aac cac cag     1020
 His Pro His Pro Ala Gly Met Arg Ile Asn Val Val Asn Asn His Gln
             305                 310                 315

 gcc aaa cag aat tta tat gac ctg gat gaa gat gat gat ggt ata gct     1068
 Ala Lys Gln Asn Leu Tyr Asp Leu Asp Glu Asp Asp Asp Gly Ile Ala
         320                 325                 330

 tcc gtt cct act aaa cag atg aag ttt gca gcc tca ggc ggc ttt ctc     1116
 Ser Val Pro Thr Lys Gln Met Lys Phe Ala Ala Ser Gly Gly Phe Leu
     335                 340                 345

 cac cac atg gct ggg cta agc agt tcc aag ctt tcc atg tcc aag gcc     1164
 His His Met Ala Gly Leu Ser Ser Ser Lys Leu Ser Met Ser Lys Ala
 350                 355                 360                 365

 ctc cct ctc acc aaa gtg gtt cag aat gat gca tac aca gct cct gct     1212
 Leu Pro Leu Thr Lys Val Val Gln Asn Asp Ala Tyr Thr Ala Pro Ala
                 370                 375                 380

 ctc cct tcc tct att cga aca aaa gcc ttg acc aac atg tcc cgg aca     1260
 Leu Pro Ser Ser Ile Arg Thr Lys Ala Leu Thr Asn Met Ser Arg Thr
             385                 390                 395

 ctg gtg aac aag gaa gaa ccc ccc aaa gag ctg cca gct gct gag cct     1308
 Leu Val Asn Lys Glu Glu Pro Pro Lys Glu Leu Pro Ala Ala Glu Pro
         400                 405                 410

 gtt ctc agc cca ttg gaa ggc acc aag atg act gtg aat aat ctg cac     1356
 Val Leu Ser Pro Leu Glu Gly Thr Lys Met Thr Val Asn Asn Leu His
     415                 420                 425

 cct cga gtc act gag gag gac att gtt gag ctt ttc tgt gtg tgt ggg     1404
 Pro Arg Val Thr Glu Glu Asp Ile Val Glu Leu Phe Cys Val Cys Gly
 430                 435                 440                 445

 gcc ctc aag cga gct cga ctg gtc cat cct ggg gta gcg gag gtg gtg     1452
 Ala Leu Lys Arg Ala Arg Leu Val His Pro Gly Val Ala Glu Val Val
                 450                 455                 460

 ttt gtg aaa aag gac gat gcc atc acc gca tat aag aag tac aac aac     1500
 Phe Val Lys Lys Asp Asp Ala Ile Thr Ala Tyr Lys Lys Tyr Asn Asn
             465                 470                 475

 cgg tgt ctg gac ggg cag ccg atg aag tgc aac ctt cac atg aat ggg     1548
 Arg Cys Leu Asp Gly Gln Pro Met Lys Cys Asn Leu His Met Asn Gly
         480                 485                 490

 aat gtt atc acc tca gac cag ccc atc ctg ctg cgg ctg agt gac agc     1596
 Asn Val Ile Thr Ser Asp Gln Pro Ile Leu Leu Arg Leu Ser Asp Ser
     495                 500                 505

 cca tca atg aaa aag gag agc gag ctg cct cgc agg gtg aac tct gcc     1644
 Pro Ser Met Lys Lys Glu Ser Glu Leu Pro Arg Arg Val Asn Ser Ala
 510                 515                 520                 525

 tcc tcc tcc aac ccc cct gct gaa gtg gac cct gac acc atc ctg aag     1692
 Ser Ser Ser Asn Pro Pro Ala Glu Val Asp Pro Asp Thr Ile Leu Lys
                 530                 535                 540

 gca ctc ttc aag tcc tca ggg gcc tct gtg acc acg cag ccc aca gaa     1740
 Ala Leu Phe Lys Ser Ser Gly Ala Ser Val Thr Thr Gln Pro Thr Glu
             545                 550                 555

 ttc aaa atc aag ctt tga gcaggg gagtgaggca gccagaagtg ggggcagagg     1794
 Phe Lys Ile Lys Leu 
         560

 agggtggctc tgtttcccca aggcaaagct tatgaccaat gggccatcgg actggagacc   1854

 cctgattgtg ggaagggttg ccagggataa agagcttcct cactggaaaa aaaaaaaaa    1913




      <210> 85
      <211> 666
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (478)..(624)

      <400> 85
 aaaacagtgt agtctttgtg actgaatggt gtgtatgctt tcactgttgt ttttggatat     60

 ggaacaactt ttatctccag tgtaatggct ccatggctgg gaaggcagcg acaatgacag    120

 cacacagcac tgttgggttt tcttttactc tattttccta acaacttagt gtttggattt    180

 taccctttag aagttggatt caagcttcct tcttgaggta gcccctaagt gtcatgggct    240

 caaacaccca ctaccaaaag agtctgctct tttcatggta gcttttggca gacctggaag    300

 gagattgtgt cacatggcct gtaaacaaaa ccagtaattc actgggtgaa gaccaaatgc    360

 ctcatcaact gccaagcctc tgtctgtctc ccttagatca gtagcccatg atccctttac    420

 gaacctcagc ctcggctctg cttttattgt ttttcactgc atagcgctgc ctttgct       477                                                                 
 atg tcc ttt agt tca cca tct atg aat tgg caa gaa aaa ttt tcc tgc      525
 Met Ser Phe Ser Ser Pro Ser Met Asn Trp Gln Glu Lys Phe Ser Cys
   1               5                  10                  15

 cag gca cag tgg ctc act cct gtg ctc cca gca ctt tgg gag gct gaa      573
 Gln Ala Gln Trp Leu Thr Pro Val Leu Pro Ala Leu Trp Glu Ala Glu
              20                  25                  30

 gtg gga gca ttg ctt gag ccc aga agt ttg aga cca gcc tgg gca aca      621
 Val Gly Ala Leu Leu Glu Pro Arg Ser Leu Arg Pro Ala Trp Ala Thr
          35                  40                  45

 tag agagacccca tctctacaca aaatttaaac aaaaaaaaaa aa                   666
 






      <210> 86
      <211> 1157
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (258)..(911)

      <400> 86
 cacgcgtccg gaacacagta cttggcacaa tgccaaattg aatgaggagg gaagaaggag     60

 agggaagcac acattgacat taagagtaaa agaattgttc ttaccatgtt atatacttta    120

 atatatggaa tcgcctgaat acaggtctcc atacaaaact ctaagaaact tctaaggaat    180

 cccttaccta taaagctctt ttggaaagaa tgaggtttta attttcttct aacatcaaca    240

 aaccctcaca aatattc   atg ttg cag acc aaa cct gga cca ccc aaa aag     290
                      Met Leu Gln Thr Lys Pro Gly Pro Pro Lys Lys
                        1               5                  10

 ccg aag acc cct tca aga cca tca gcc tta gca tat tgc tat cac tgc      338
 Pro Lys Thr Pro Ser Arg Pro Ser Ala Leu Ala Tyr Cys Tyr His Cys
              15                  20                  25

 gcg caa aaa ggc cat tat gga cac gaa tgt cca gaa aga gaa gtg tat      386
 Ala Gln Lys Gly His Tyr Gly His Glu Cys Pro Glu Arg Glu Val Tyr
          30                  35                  40

 gac ccg tct cca gta tct cca ttc atc tgc tac tat gat gac aaa tat      434
 Asp Pro Ser Pro Val Ser Pro Phe Ile Cys Tyr Tyr Asp Asp Lys Tyr
      45                  50                  55

 gaa att cag gag aga gaa aag aga cta aaa caa aaa ata aaa gta ctc      482
 Glu Ile Gln Glu Arg Glu Lys Arg Leu Lys Gln Lys Ile Lys Val Leu
  60                  65                  70                  75

 aag aaa aat ggg gtt atc cca gag cca tcc aag cta cct tat ata aaa      530
 Lys Lys Asn Gly Val Ile Pro Glu Pro Ser Lys Leu Pro Tyr Ile Lys
                  80                  85                  90

 gca gca aat gag aac ccc cac cat gat ata agg aag ggc cgt gcc tca      578
 Ala Ala Asn Glu Asn Pro His His Asp Ile Arg Lys Gly Arg Ala Ser
              95                 100                 105

 tgg aaa agc aac agg tgg cct caa gaa aat aaa gaa aca caa aaa gaa      626
 Trp Lys Ser Asn Arg Trp Pro Gln Glu Asn Lys Glu Thr Gln Lys Glu
         110                 115                 120

 atg aag aac aag aat aga aac tgg gag aag cac agg aag gct gac aga      674
 Met Lys Asn Lys Asn Arg Asn Trp Glu Lys His Arg Lys Ala Asp Arg
     125                 130                 135

 cat cgt gaa gtg gat gag gat ttt ccc agg ggc ccc aaa acc tac tct      722
 His Arg Glu Val Asp Glu Asp Phe Pro Arg Gly Pro Lys Thr Tyr Ser
 140                 145                 150                 155

 tct cct ggc agt ttt aaa acc cag aag cct tct aag ccc ttt cac cgt      770
 Ser Pro Gly Ser Phe Lys Thr Gln Lys Pro Ser Lys Pro Phe His Arg
                 160                 165                 170

 tca tca cat tac cac acg tca aga gaa gac aag tct ccc aag gaa ggc      818
 Ser Ser His Tyr His Thr Ser Arg Glu Asp Lys Ser Pro Lys Glu Gly
             175                 180                 185

 aag agg ggc aag cag aag aaa aag gag agg tgc tgg gaa gat gat gac      866
 Lys Arg Gly Lys Gln Lys Lys Lys Glu Arg Cys Trp Glu Asp Asp Asp
         190                 195                 200

 aat gat aac tta ttt ctt att aag cag aga aaa aaa aag tct taa gcc      914
 Asn Asp Asn Leu Phe Leu Ile Lys Gln Arg Lys Lys Lys Ser 
     205                 210                 215

 gtcaggcagc ctctgatgtg gcttttcatt gttcatttgg cctttgtgtc tataaccttc    974

 tggcactgtg tttattatct atgattaaat aaagtgagtt tttggttttg tttttttaat   1034

 ttcagccatt cctagagtta ctgaatatcc atggagatct caattctctg tgtccaacag   1094

 gatattaggt aagaaagtac aaagataaac ctggacttct cctattccaa tatgtcatct   1154

 tta                                                                 1157




      <210> 87
      <211> 964
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (10)..(816)

      <400> 87
 ctgatttgc    atg gat gga ctc tcc ccc tct cag agt atg aag aga ggg      48
              Met Asp Gly Leu Ser Pro Ser Gln Ser Met Lys Arg Gly
                1               5                  10

 aga gat ctg ggg gaa gct cag ctt cag ctg tgg gta gag aag aca gga       96
 Arg Asp Leu Gly Glu Ala Gln Leu Gln Leu Trp Val Glu Lys Thr Gly
      15                  20                  25

 ctc agg aca atc tcc agc atg gcc agc ttc cct ctc ctc ctc acc ctc      144
 Leu Arg Thr Ile Ser Ser Met Ala Ser Phe Pro Leu Leu Leu Thr Leu
  30                  35                  40                  45

 ctc act cac tgt gca ggg tcc tgg gcc cag tct gtg ctg act cag cca      192
 Leu Thr His Cys Ala Gly Ser Trp Ala Gln Ser Val Leu Thr Gln Pro
                  50                  55                  60

 ccc tca gcg tct ggg acc ccc ggg cag agg gtc acc atc tct tgt tct      240
 Pro Ser Ala Ser Gly Thr Pro Gly Gln Arg Val Thr Ile Ser Cys Ser
              65                  70                  75

 gga agc cgc tcc aac gtc gga agt aat aat gtt aac tgg tac cag cag      288
 Gly Ser Arg Ser Asn Val Gly Ser Asn Asn Val Asn Trp Tyr Gln Gln
          80                  85                  90

 ctc cca gga acg gcc ccc aaa ctc ctc atc tat agt aat aat cag cgg      336
 Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile Tyr Ser Asn Asn Gln Arg
      95                 100                 105

 ccc tca ggg gtc cct gac cga ttc tct ggc tcc aag tct ggc acc tca      384
 Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser
 110                 115                 120                 125

 gcc tcc ctg gcc atc agt ggg ctc cag tct gag gat gag gct gat tat      432
 Ala Ser Leu Ala Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr
                 130                 135                 140

 tac tgt gca aca tgg gat gac agt act gtg gtc ttc ggc gga ggg acc      480
 Tyr Cys Ala Thr Trp Asp Asp Ser Thr Val Val Phe Gly Gly Gly Thr
             145                 150                 155

 aag ctg acc gtc cct ggt cag ccc aag gct gcc ccc tcg gtc act ctg      528
 Lys Leu Thr Val Pro Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu
         160                 165                 170

 ttc ccg ccc tcc tct gag gag ctt caa gcc aac aag gcc aca ctg gtg      576
 Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val
     175                 180                 185

 tgt ctc ata agt gac ttc tac ccg gga gcc gtg aca gtg gcc tgg aag      624
 Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys
 190                 195                 200                 205

 gca gat agc agc ccc gtc aag gcg gga gtg gag acc acc aca ccc tcc      672
 Ala Asp Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser
                 210                 215                 220

 aaa caa agc aac aac aag tac gcg gcc agc agc tat ctg agc ctg acg      720
 Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr
             225                 230                 235

 cct gag cag tgg aag tcc cac aga agc tac agc tgc cag gtc acg cat      768
 Pro Glu Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His
         240                 245                 250

 gaa ggg agc acc gtg gag aag aca gtg gcc cct aca gaa tgt tca tag      816
 Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
     255                 260                 265

 gttctcaacc ctcacccccc accacgggag actagagctg caggatccca ggggaggggt    876

 ctctcctccc accccaaggc atcaagccct tctccctgca ctcaataaac cctcaataaa    936

 tattctcatt gtcaatcaaa aaaaaaaa                                       964




      <210> 88
      <211> 755
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (259)..(672)

      <400> 88
 tctcactgag aaatcaaggg gcagaatcaa tatcgttacc gttcactgaa cagccatttt     60

 caaatggaca agatggagat aggctcctga gtattttgaa aaacaataga aagagcccct    120

 cacagtccag ccttctaggt aacaaattta aaaacaaaat atttgaaaaa aaaattagaa    180

 actgcgcaac cacaggaaaa ccgcctggca aagattcaaa gtgtaggcaa aaacctgcag    240

 agagtgaaca gagtcctc  atg ggc cca agg agc atc cag gaa agg cac ttc     291
                      Met Gly Pro Arg Ser Ile Gln Glu Arg His Phe
                        1               5                  10

 aaa aag gtg gga aag cac agc act agg aaa gaa cag gat gcc cag gca      339
 Lys Lys Val Gly Lys His Ser Thr Arg Lys Glu Gln Asp Ala Gln Ala
              15                  20                  25

 ttt gtg gac aat gct gcc aaa gga aaa agg ctt gag ggt cca gcc cca      387
 Phe Val Asp Asn Ala Ala Lys Gly Lys Arg Leu Glu Gly Pro Ala Pro
          30                  35                  40

 agg gag ctg gaa cag cct cac ata gtg cag ggg cct gag aag gta gtg      435
 Arg Glu Leu Glu Gln Pro His Ile Val Gln Gly Pro Glu Lys Val Val
      45                  50                  55

 gga aac acc atc tac acc aag cct tca ttc acc caa gag cat aag gca      483
 Gly Asn Thr Ile Tyr Thr Lys Pro Ser Phe Thr Gln Glu His Lys Ala
  60                  65                  70                  75

 gca gtc tcc tct gtg ctg aaa ccc ttc tcc atg ggc gtg cct tct gcc      531
 Ala Val Ser Ser Val Leu Lys Pro Phe Ser Met Gly Val Pro Ser Ala
                  80                  85                  90

 tct agc cct gca aaa gcc cta cct cag gtc aga gac aga tcg aaa gac      579
 Ser Ser Pro Ala Lys Ala Leu Pro Gln Val Arg Asp Arg Ser Lys Asp
              95                 100                 105

 tta gcc tac acc att tta att tta gaa atg gca atg gct aga gtg aaa      627
 Leu Ala Tyr Thr Ile Leu Ile Leu Glu Met Ala Met Ala Arg Val Lys
         110                 115                 120

 aac atg aag gct gct aaa cca atc aca cat tcc aga aaa aaa tag cgc      675
 Asn Met Lys Ala Ala Lys Pro Ile Thr His Ser Arg Lys Lys 
     125                 130                 135

 ttttataaaa ctcactccat tgtggcccac agaacaccca aggccaaaaa gattagaaag    735

 tttagaaagg gcagtgtatt                                                755




      <210> 89
      <211> 5599
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (314)..(4159)

      <400> 89
 tcagccatta ctttgctcgg cgctgctccc aggcatctcc gaccctcggt gctgtgggga     60

 gccccacact tgggctcctc gcctctcgcc ctcgctcccc gtccctcctc ccctctctcc    120

 gccccttccc ccttttcttt ctcctctctt tcttcccctc tctcccttct ttcggccgcc    180

 gtctcccccg cgccctcctc ggggcggagg gaagccgtga agggggaggg agggctcggt    240

 gtcaattttt ttttgtgtgg ctgcggccgt agcctgtggc gggcaagcgg ggagaccccg    300

 gcgcagcaga acc   atg gat ggc ccg acg cgg ggc cat gga ctc cgc aaa     349
                  Met Asp Gly Pro Thr Arg Gly His Gly Leu Arg Lys
                    1               5                  10

 aag cgg cgg tcg cgg tcg cag cga gac cgg gag agg cgc tcc cgg ggc      397
 Lys Arg Arg Ser Arg Ser Gln Arg Asp Arg Glu Arg Arg Ser Arg Gly
          15                  20                  25

 ggg ctg ggg gcc ggc gcg gcc ggc ggc ggc ggg gct ggc cgg acc cgg      445
 Gly Leu Gly Ala Gly Ala Ala Gly Gly Gly Gly Ala Gly Arg Thr Arg
      30                  35                  40

 gcg ctc tca ctc gcc tcg tcg tcg ggc tcc gac aag gaa gac aat ggg      493
 Ala Leu Ser Leu Ala Ser Ser Ser Gly Ser Asp Lys Glu Asp Asn Gly
  45                  50                  55                  60

 aag ccc ccg tcc tcc gcc ccg tcc cgg ccc aga ccc ccg cgg agg aag      541
 Lys Pro Pro Ser Ser Ala Pro Ser Arg Pro Arg Pro Pro Arg Arg Lys
                  65                  70                  75

 cgg aga gag tcc acc tcg gca gaa gag gac atc att gat gga ttt gcc      589
 Arg Arg Glu Ser Thr Ser Ala Glu Glu Asp Ile Ile Asp Gly Phe Ala
              80                  85                  90

 atg acc agc ttt gtc act ttt gaa gcg ctg gag aaa gat gta gca ctt      637
 Met Thr Ser Phe Val Thr Phe Glu Ala Leu Glu Lys Asp Val Ala Leu
          95                 100                 105

 aag cct cag gaa cgt gtg gag aaa cgc cag acg ccc ctg acc aag aag      685
 Lys Pro Gln Glu Arg Val Glu Lys Arg Gln Thr Pro Leu Thr Lys Lys
     110                 115                 120

 aaa cga gaa gca ctt acc aat ggc ttg tcc ttt cat tca aag aag agc      733
 Lys Arg Glu Ala Leu Thr Asn Gly Leu Ser Phe His Ser Lys Lys Ser
 125                 130                 135                 140

 aga ctc agc cac cca cac cac tac agc tca gat cga gaa aat gac cgc      781
 Arg Leu Ser His Pro His His Tyr Ser Ser Asp Arg Glu Asn Asp Arg
                 145                 150                 155

 aat ctc tgc cag cac ctt ggg aag aga aag aaa atg ccg aag gca ctc      829
 Asn Leu Cys Gln His Leu Gly Lys Arg Lys Lys Met Pro Lys Ala Leu
             160                 165                 170

 aga cag ctc aag cca gga cag aac agc tgc agg gac agt gac agt gaa      877
 Arg Gln Leu Lys Pro Gly Gln Asn Ser Cys Arg Asp Ser Asp Ser Glu
         175                 180                 185

 agt gcc agt gga gaa tcc aag ggc ttc cac cgg agc agc tct cgg gaa      925
 Ser Ala Ser Gly Glu Ser Lys Gly Phe His Arg Ser Ser Ser Arg Glu
     190                 195                 200

 agg ctc agt gat agt tca gct cct tcc agc ttg gga aca ggc tac ttc      973
 Arg Leu Ser Asp Ser Ser Ala Pro Ser Ser Leu Gly Thr Gly Tyr Phe
 205                 210                 215                 220

 tgt gac agt gac agt gac cag gaa gag aag gca tca gat gcc agc tct     1021
 Cys Asp Ser Asp Ser Asp Gln Glu Glu Lys Ala Ser Asp Ala Ser Ser
                 225                 230                 235

 gaa aaa ctc ttc aac act gtt att gta aac aaa gat ccg gag tta ggt     1069
 Glu Lys Leu Phe Asn Thr Val Ile Val Asn Lys Asp Pro Glu Leu Gly
             240                 245                 250

 gtt ggc acg cta cca gaa cat gac agc cag gat gca ggg ccg att gtc     1117
 Val Gly Thr Leu Pro Glu His Asp Ser Gln Asp Ala Gly Pro Ile Val
         255                 260                 265

 ccc aag ata tcg ggt cta gag aga agc cag gag aag agc cag gac tgt     1165
 Pro Lys Ile Ser Gly Leu Glu Arg Ser Gln Glu Lys Ser Gln Asp Cys
     270                 275                 280

 tgc aaa gag cca atc ttt gag cct gtg gtg ctt aaa gac ccc tgc cct     1213
 Cys Lys Glu Pro Ile Phe Glu Pro Val Val Leu Lys Asp Pro Cys Pro
 285                 290                 295                 300

 cag gtc gca cag cca ata ccc cag ccg cag acg gag ccc caa ctc cga     1261
 Gln Val Ala Gln Pro Ile Pro Gln Pro Gln Thr Glu Pro Gln Leu Arg
                 305                 310                 315

 gct cct tct ccg gac cct gac ttg gtg cag cgc aca gag gcc cca cct     1309
 Ala Pro Ser Pro Asp Pro Asp Leu Val Gln Arg Thr Glu Ala Pro Pro
             320                 325                 330

 caa ccc cca cct ctg agt aca cag cca cca cag ggc cct cct gag gcc     1357
 Gln Pro Pro Pro Leu Ser Thr Gln Pro Pro Gln Gly Pro Pro Glu Ala
         335                 340                 345

 cag ctc cag cct gcc ccg cag cct cag gtg cag agg cca ccc agg cca     1405
 Gln Leu Gln Pro Ala Pro Gln Pro Gln Val Gln Arg Pro Pro Arg Pro
     350                 355                 360

 cag tcc ccc acc cag ctg ctc cat cag aac ctc cca cct gtg cag gcc     1453
 Gln Ser Pro Thr Gln Leu Leu His Gln Asn Leu Pro Pro Val Gln Ala
 365                 370                 375                 380

 cac ccc tct gct cag agc ctc tcc cag cca ttg tca gcc tac aac agc     1501
 His Pro Ser Ala Gln Ser Leu Ser Gln Pro Leu Ser Ala Tyr Asn Ser
                 385                 390                 395

 agt agc tta agc ctc aac agt tta agc agc agc aga agc agc act cca     1549
 Ser Ser Leu Ser Leu Asn Ser Leu Ser Ser Ser Arg Ser Ser Thr Pro
             400                 405                 410

 gcg aag act cag ccc gcc cca cct cac atc tcc cac cac ccc tct gcc     1597
 Ala Lys Thr Gln Pro Ala Pro Pro His Ile Ser His His Pro Ser Ala
         415                 420                 425

 tcc ccg ttc ccc ctc tcc ctg ccc aac cac agc ccc ctg cac agc ttc     1645
 Ser Pro Phe Pro Leu Ser Leu Pro Asn His Ser Pro Leu His Ser Phe
     430                 435                 440

 aca ccc acc ctc cag ccc ccc gca cac tca cat cac ccc aat atg ttt     1693
 Thr Pro Thr Leu Gln Pro Pro Ala His Ser His His Pro Asn Met Phe
 445                 450                 455                 460

 gcc cct ccc act gct ctg cct cct cca cca cca ctg aca tca gga agt     1741
 Ala Pro Pro Thr Ala Leu Pro Pro Pro Pro Pro Leu Thr Ser Gly Ser
                 465                 470                 475

 ctg cag gtg gcc gga cac ccg gcc ggg agc act tac tca gag caa gac     1789
 Leu Gln Val Ala Gly His Pro Ala Gly Ser Thr Tyr Ser Glu Gln Asp
             480                 485                 490

 atc ttg cga cag gaa ctg aac act cgt ttt ttg gcc tct cag agt gct     1837
 Ile Leu Arg Gln Glu Leu Asn Thr Arg Phe Leu Ala Ser Gln Ser Ala
         495                 500                 505

 gac cgc ggg gct tcc ctg ggc cct ccg ccc tac ctg cgg acc gag ttc     1885
 Asp Arg Gly Ala Ser Leu Gly Pro Pro Pro Tyr Leu Arg Thr Glu Phe
     510                 515                 520

 cat cag cac cag cac cag cac cag cac acc cac cag cac acg cac cag     1933
 His Gln His Gln His Gln His Gln His Thr His Gln His Thr His Gln
 525                 530                 535                 540

 cac acc ttc acg ccg ttc ccc cac gcc atc cca ccc acc gcc atc atg     1981
 His Thr Phe Thr Pro Phe Pro His Ala Ile Pro Pro Thr Ala Ile Met
                 545                 550                 555

 ccg acg cca gca cct ccc atg ttt gac aaa tac cct aca aaa gtt gac     2029
 Pro Thr Pro Ala Pro Pro Met Phe Asp Lys Tyr Pro Thr Lys Val Asp
             560                 565                 570

 cca ttc tac cgg cac agt ctc ttc cat tcc tat cct cct gca gtg tcg     2077
 Pro Phe Tyr Arg His Ser Leu Phe His Ser Tyr Pro Pro Ala Val Ser
         575                 580                 585

 ggc atc ccc cct atg atc cca ccc act ggc cct ttt ggt tca cta caa     2125
 Gly Ile Pro Pro Met Ile Pro Pro Thr Gly Pro Phe Gly Ser Leu Gln
     590                 595                 600

 gga gca ttt cag ccg aag aca tcc aac cct atc gat gtc gct gct cgg     2173
 Gly Ala Phe Gln Pro Lys Thr Ser Asn Pro Ile Asp Val Ala Ala Arg
 605                 610                 615                 620

 cct ggg aca gtc cca cac act tta ctc caa aag gac ccg agg ttg aca     2221
 Pro Gly Thr Val Pro His Thr Leu Leu Gln Lys Asp Pro Arg Leu Thr
                 625                 630                 635

 gat cct ttc aga cct atg tta agg aaa cca ggg aag tgg tgt gct atg     2269
 Asp Pro Phe Arg Pro Met Leu Arg Lys Pro Gly Lys Trp Cys Ala Met
             640                 645                 650

 cat gtt cac atc gcc tgg cag att tac cac cac caa cag aaa gtc aag     2317
 His Val His Ile Ala Trp Gln Ile Tyr His His Gln Gln Lys Val Lys
         655                 660                 665

 aaa cag atg cag tca gac cca cat aag ctg gac ttt gga ctg aaa cct     2365
 Lys Gln Met Gln Ser Asp Pro His Lys Leu Asp Phe Gly Leu Lys Pro
     670                 675                 680

 gag ttc ctg agc cgc cct cca ggc ccc agt ctt ttt gga gcc atc cac     2413
 Glu Phe Leu Ser Arg Pro Pro Gly Pro Ser Leu Phe Gly Ala Ile His
 685                 690                 695                 700

 cac ccc cat gac ctg gca cgg cct tca act ttg ttc tct gcc gct ggt     2461
 His Pro His Asp Leu Ala Arg Pro Ser Thr Leu Phe Ser Ala Ala Gly
                 705                 710                 715

 gct gca cac cca act ggg acc cct ttt ggg cca cct cct cat cac agc     2509
 Ala Ala His Pro Thr Gly Thr Pro Phe Gly Pro Pro Pro His His Ser
             720                 725                 730

 aac ttc ctc aac cct gct gcc cac cta gag cct ttt aat cgg ccg tct     2557
 Asn Phe Leu Asn Pro Ala Ala His Leu Glu Pro Phe Asn Arg Pro Ser
         735                 740                 745

 aca ttc aca ggc cta gca gca gtt ggt ggc aat gcc ttc ggg gga ctt     2605
 Thr Phe Thr Gly Leu Ala Ala Val Gly Gly Asn Ala Phe Gly Gly Leu
     750                 755                 760

 gga aat cct tcc gtt aca ccc aac tca atg ttc ggc cac aag gat ggc     2653
 Gly Asn Pro Ser Val Thr Pro Asn Ser Met Phe Gly His Lys Asp Gly
 765                 770                 775                 780

 ccc agt gtg cag aac ttt agc aac cct cac gaa ccc tgg aac cgg ctg     2701
 Pro Ser Val Gln Asn Phe Ser Asn Pro His Glu Pro Trp Asn Arg Leu
                 785                 790                 795

 cac cga acg cct ccg tcg ttc ccg acc cct ccg ccc tgg ctg aag cca     2749
 His Arg Thr Pro Pro Ser Phe Pro Thr Pro Pro Pro Trp Leu Lys Pro
             800                 805                 810

 ggg gag ctg gag cgc agc gcg tcc gct gca gct cat gac aga gat aga     2797
 Gly Glu Leu Glu Arg Ser Ala Ser Ala Ala Ala His Asp Arg Asp Arg
         815                 820                 825

 gat gta gat aaa cga gac tca tct gtt agt aaa gat gac aaa gaa agg     2845
 Asp Val Asp Lys Arg Asp Ser Ser Val Ser Lys Asp Asp Lys Glu Arg
     830                 835                 840

 gaa agc gtc gag aag aga cac tcc agc cac cct tca cca gca cct gtc     2893
 Glu Ser Val Glu Lys Arg His Ser Ser His Pro Ser Pro Ala Pro Val
 845                 850                 855                 860

 ctc ccg gtg aat gcc ctg gga cat acc cgc agc tcc act gaa cag atc     2941
 Leu Pro Val Asn Ala Leu Gly His Thr Arg Ser Ser Thr Glu Gln Ile
                 865                 870                 875

 cgg gct cat ctg aac act gag gct cgg gag aag gac aaa ccc aaa gag     2989
 Arg Ala His Leu Asn Thr Glu Ala Arg Glu Lys Asp Lys Pro Lys Glu
             880                 885                 890

 agg gag aga gac cac tcg gaa tcc cgc aag gac ctg gcc gcc gac gag     3037
 Arg Glu Arg Asp His Ser Glu Ser Arg Lys Asp Leu Ala Ala Asp Glu
         895                 900                 905

 cac aag gcg aaa gag ggc cac ctg ccc gag aag gac ggg cac ggc cac     3085
 His Lys Ala Lys Glu Gly His Leu Pro Glu Lys Asp Gly His Gly His
     910                 915                 920

 gag ggg cgc gcc gcg ggc gaa gag gcc aag cag ctg gcc cgg gtg ccg     3133
 Glu Gly Arg Ala Ala Gly Glu Glu Ala Lys Gln Leu Ala Arg Val Pro
 925                 930                 935                 940

 tct ccc tac gtg cgg acc ccg gtg gtg gag agt gcc agg ccc aac agc     3181
 Ser Pro Tyr Val Arg Thr Pro Val Val Glu Ser Ala Arg Pro Asn Ser
                 945                 950                 955

 acc tcg agc ccg gga ggg ccg agc ccg cgc aag ggt gag ccg gcc tac     3229
 Thr Ser Ser Pro Gly Gly Pro Ser Pro Arg Lys Gly Glu Pro Ala Tyr
             960                 965                 970

 gag aac ccc aag aag agc tcc gag gtc aag gtg aag gag gag cgg aag     3277
 Glu Asn Pro Lys Lys Ser Ser Glu Val Lys Val Lys Glu Glu Arg Lys
         975                 980                 985

 gaa gac cat gac ctg cct cca gag gcc ccg cag acc cac cgg gcc tcg     3325
 Glu Asp His Asp Leu Pro Pro Glu Ala Pro Gln Thr His Arg Ala Ser
     990                 995                1000

 gag ccg ccg cct ccc aac tcc tcg tcc agc gtg cac ccg ggg ccc ctg     3373
 Glu Pro Pro Pro Pro Asn Ser Ser Ser Ser Val His Pro Gly Pro Leu
1005                1010                1015                1020

 gcc tcg atg ccc atg acg gtg ggg gtg acg ggc att cac ccc atg aac     3421
 Ala Ser Met Pro Met Thr Val Gly Val Thr Gly Ile His Pro Met Asn
                1025                1030                1035

 agc atc agc agc ctg gac agg act cgc atg atg acc ccc ttc atg ggc     3469
 Ser Ile Ser Ser Leu Asp Arg Thr Arg Met Met Thr Pro Phe Met Gly
            1040                1045                1050

 atc agc ccc ctc ccg ggc gga gag cgc ttc ccg tac cct tct ttc cac     3517
 Ile Ser Pro Leu Pro Gly Gly Glu Arg Phe Pro Tyr Pro Ser Phe His
        1055                1060                1065

 tgg gac ccc atc cgg gac ccc ttg agg gat cct tac cga gaa ctt gac     3565
 Trp Asp Pro Ile Arg Asp Pro Leu Arg Asp Pro Tyr Arg Glu Leu Asp
    1070                1075                1080

 att cac cgg aga gac ccg ctg ggc agg gac ttc ctg cta agg aac gac     3613
 Ile His Arg Arg Asp Pro Leu Gly Arg Asp Phe Leu Leu Arg Asn Asp
1085                1090                1095                1100

 ccg ctc cac cgg ctc tcg act ccc cgg ctg tac gaa gcc gac cgc tcc     3661
 Pro Leu His Arg Leu Ser Thr Pro Arg Leu Tyr Glu Ala Asp Arg Ser
                1105                1110                1115

 ttc agg gac cgg gag cct cac gac tac agc cac cac cac cac cac cac     3709
 Phe Arg Asp Arg Glu Pro His Asp Tyr Ser His His His His His His
            1120                1125                1130

 cac cac ccg ctg tct gtg gac cct cgg cgg gag cac gag cgg gga ggc     3757
 His His Pro Leu Ser Val Asp Pro Arg Arg Glu His Glu Arg Gly Gly
        1135                1140                1145

 cac ctg gac gag cgg gag cgc ttg cac atg ctc aga gaa gac tac gag     3805
 His Leu Asp Glu Arg Glu Arg Leu His Met Leu Arg Glu Asp Tyr Glu
    1150                1155                1160

 cac acg cgg ctc cac tcc gtg cac ccc gcc tcc ctc gac gga cac ctc     3853
 His Thr Arg Leu His Ser Val His Pro Ala Ser Leu Asp Gly His Leu
1165                1170                1175                1180

 ccc cac ccc agc ctc atc acc ccg gga ctc ccc agc atg cac tat ccc     3901
 Pro His Pro Ser Leu Ile Thr Pro Gly Leu Pro Ser Met His Tyr Pro
                1185                1190                1195

 cgc atc agc ccc acc gcg ggc aac cag aac gga ctc ctc aac aag acc     3949
 Arg Ile Ser Pro Thr Ala Gly Asn Gln Asn Gly Leu Leu Asn Lys Thr
            1200                1205                1210

 cct ccg aca gca gcg ctg agc gca cct ccc ccg ctc atc tcc acg ctg     3997
 Pro Pro Thr Ala Ala Leu Ser Ala Pro Pro Pro Leu Ile Ser Thr Leu
        1215                1220                1225

 ggg ggc cgc ccg gtc tct ccc aga agg acg act cct ctg tcc gca gag     4045
 Gly Gly Arg Pro Val Ser Pro Arg Arg Thr Thr Pro Leu Ser Ala Glu
    1230                1235                1240

 ata agg gga gag gcc ccc ttc cca cac gct gaa gga tat cga ggc ccg     4093
 Ile Arg Gly Glu Ala Pro Phe Pro His Ala Glu Gly Tyr Arg Gly Pro
1245                1250                1255                1260

 ata agc cga gaa cag gag caa gaa cga gga aga aga aac cct agg cag     4141
 Ile Ser Arg Glu Gln Glu Gln Glu Arg Gly Arg Arg Asn Pro Arg Gln
                1265                1270                1275

 aca cca ggc cag gct tga gagaca gaactcctgc atggctcaca cagactgggg     4195
 Thr Pro Gly Gln Ala 
            1280

 gggaaagccc caccccttcc ccttgtaaaa aatgtataga ctcagtgcac attttgaaat   4255

 gttttgtata ttatatgttg agatttttca gatcttttag cccagtcata tgttctcacg   4315

 tctcctactt tttgtttctc gtataaaact ttttgatttg aaccaaaaca gtgaagatga   4375

 caacacacac caattggatg ataattgtag cgggggcggt gggggggaga agtccacgcc   4435

 atccatcatg caaaattctt tcagatgagg tgggaaggcc gtgtacatag ttatgtaaaa   4495

 agagattgct tcatgagcta atggttcata tatgcaaaag ggtaagatga aagctttact   4555

 ttgtacaaat gtaaatagat aaagtaacat aatacattaa tacttcttaa aatgtgctat   4615

 ttgcaaactt acttaatatc agtgaacaca gtcggctaaa gctgtgttcc catatattgt   4675

 tatagacagc taaacccttc aactatgcaa tgaatgttcg ggcttttcac aaaagcccgc   4735

 ctaactcaaa ggagcctttt caaatccatt tacagcatac ttaaggtcat attttccctg   4795

 aacaagcgct tacgtgatat gactctgttt tccttgcttg ttttttttca aacggagaaa   4855

 catcctgttt tgcaaattgg accccaggct ggaacttagc atctgaagtt gccgcttgtg   4915

 ggctctgggg gaaagtgtag ccccggagag gtaactgagg acatgagcaa ccagtgccag   4975

 ggagggtggg atttgccaga tgccaaaatc aggggacggg tggtggtgtc tgtcagacac   5035

 acacaggtcg ccagtgactt cacacacacc tcatgtgaga accatgcctt ttttagtgtg   5095

 tcctatttca tacctgtaca cacttcctcg ttttgtaatg agatttactt acacccaaac   5155

 agatcctgaa agaaagcttc aagttttctc agatgatgga tatgttttca ctgtattcaa   5215

 taactgacgg atgtaaggtg cacgtttcct gatgtgacgc actgtattcc agctggtgat   5275

 caagtctggg aacagccgta acaggtcaac cttgtggagc catcgcgagt tagagggtga   5335

 aagatggcag aaaaaaaagt cttgtgtgtg agtgtgtttt ttgagtttgc atcaatctta   5395

 atgtctcttc ataatacttt tataatacat taagcctctt gtctacatat ttggagagaa   5455

 tatgacttta ctagcagaga aatacaatat atcttgtcta ctggactgta aaatatatgt   5515

 atgaaataaa attagttcca tttggtcttc tagtatatta aagtgctatc tgacgttgtt   5575

 atcctgtttt tgcaaaaaaa aaaa                                          5599




      <210> 90
      <211> 834
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (317)..(718)

      <400> 90
 acacatgaga catctctcca cccccatcct gctcaccgaa gcgctcaatg actactttcc     60

 accaacactg cactataccc ccctgtgtgc cccctttcat attctgattt gcaggctact    120

 ggtccaccct gctggggtgg tctttgtttt ttggggtttt gtctcccttc acagttgaca    180

 caatccagag gacaggaagc atttctcttt tctctcaata gcaccatcca actggctgac    240

 cagccatagg tctccaagtt caggaaactg gggtttggaa agaaatgctg agcatctcga    300

 ggggttggct atctag    atg cag agt ata cta gga gtc tcc ttc cat cgt     349
                      Met Gln Ser Ile Leu Gly Val Ser Phe His Arg
                        1               5                  10

 aag gca ttc agc tgc tct ctt ggg agt ccc cat tct cct acc tca gtc      397
 Lys Ala Phe Ser Cys Ser Leu Gly Ser Pro His Ser Pro Thr Ser Val
              15                  20                  25

 tgt ccc ctg gga gga gtg act cag ggg ctg ata ctc act aga ccc tcc      445
 Cys Pro Leu Gly Gly Val Thr Gln Gly Leu Ile Leu Thr Arg Pro Ser
          30                  35                  40

 aag aga cat ggc agc tgt ggg aat att agg tca ccc cat tct acc acc      493
 Lys Arg His Gly Ser Cys Gly Asn Ile Arg Ser Pro His Ser Thr Thr
      45                  50                  55

 cag gac caa gaa aac ata gga gag tgt gct gaa gac aca ata ccc ttt      541
 Gln Asp Gln Glu Asn Ile Gly Glu Cys Ala Glu Asp Thr Ile Pro Phe
  60                  65                  70                  75

 gaa gtt tcc aaa ggg gag cct caa cca aaa gac aat ctg ata aga tct      589
 Glu Val Ser Lys Gly Glu Pro Gln Pro Lys Asp Asn Leu Ile Arg Ser
                  80                  85                  90

 ctg ttt tta ggc cag gtg ggg tat ctc atg cct gta atc cca gca ctt      637
 Leu Phe Leu Gly Gln Val Gly Tyr Leu Met Pro Val Ile Pro Ala Leu
              95                 100                 105

 tgg gag acc aag gcg ggt gga tca cga ggt cag gag ata gag agc atc      685
 Trp Glu Thr Lys Ala Gly Gly Ser Arg Gly Gln Glu Ile Glu Ser Ile
         110                 115                 120

 ctg gct aac atg gtg aaa tcc tgt ctc tac taa aaggctcc tgtagtccca      736
 Leu Ala Asn Met Val Lys Ser Cys Leu Tyr 
     125                 130

 gctactcagg aggctgaggc aggagaatgg catgaacccg aaaggaagag cttgcagtga    796

 gccgaggtcg cggacgcgtg ggtcgacccg ggaattcc                            834




      <210> 91
      <211> 3185
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (623)..(3013)

      <400> 91
 gagagaagat agaatggctc ttgacaattt attggcaaac ctacccccgg ccaagccagg     60

 aaaaagtagc agtttagaaa tgactcccta caatacacct cagctatctc cagcaaccac    120

 tccagcaaat aaaaagaatc gattacctat agcaactcgg agcagaagcc gcaccaatat    180

 gctaatggac ctacatatgg accatgaagg atcatctcaa gaaaccatcc aggaggtgca    240

 accagaagag gtgttggtca tttccttagg tacaggtccc cagcttactc cagggatgat    300

 gtcagaaaat gaggtcctaa acatgcagct ttcggatgga ggacaaggag atgtccctgt    360

 tgatgaaaac aaactccatg gtaaacctga taaaaccttg cgcttttccc tctgcagtga    420

 taatctggaa ggaatatctg aaggtccttc aaatcgctcc aattcagtgt cctccctaga    480

 cctagaagga gagtctgtgt cagaacttgg agcaggacct tctggcagta atggagttga    540

 agctctacag ctgttagaac atgagcaagc tacaacacag gataaccttg atgataagct    600

 aaggaagttt gaaattcgtg ac atg atg gga tta aca gat gat agg gac ata     652
                          Met Met Gly Leu Thr Asp Asp Arg Asp Ile
                            1               5                  10

 tca gaa aca gtg agt gag acc tgg agt aca gac gtc ttg gga agt gac      700
 Ser Glu Thr Val Ser Glu Thr Trp Ser Thr Asp Val Leu Gly Ser Asp
                  15                  20                  25

 ttt gac cct aat att gat gaa gat cgc ttg caa gaa att gca ggt gct      748
 Phe Asp Pro Asn Ile Asp Glu Asp Arg Leu Gln Glu Ile Ala Gly Ala
              30                  35                  40

 gca gca gag aac atg tta ggc agt ttg ctg tgc ctc cca ggt tca ggg      796
 Ala Ala Glu Asn Met Leu Gly Ser Leu Leu Cys Leu Pro Gly Ser Gly
          45                  50                  55

 tca gtg ctt ctt gac ccc tgc act ggt tct acc ata tca gag aca aca      844
 Ser Val Leu Leu Asp Pro Cys Thr Gly Ser Thr Ile Ser Glu Thr Thr
      60                  65                  70

 agt gaa gct tgg agt gta gag gta ttg cca agt gac tca gag gcc cca      892
 Ser Glu Ala Trp Ser Val Glu Val Leu Pro Ser Asp Ser Glu Ala Pro
  75                  80                  85                  90

 gac cta aag cag gag gag cgt ctg caa gaa ctg gag agc tgt tct gga      940
 Asp Leu Lys Gln Glu Glu Arg Leu Gln Glu Leu Glu Ser Cys Ser Gly
                  95                 100                 105

 ctg ggt agc aca tct gat gat acg gat gtc agg gag gtc agt tcc cgc      988
 Leu Gly Ser Thr Ser Asp Asp Thr Asp Val Arg Glu Val Ser Ser Arg
             110                 115                 120

 ccc agc aca cca ggc ctc agt gtt gtg tcc ggc ata agt gca acc tct     1036
 Pro Ser Thr Pro Gly Leu Ser Val Val Ser Gly Ile Ser Ala Thr Ser
         125                 130                 135

 gag gat att ccc aat aag att gaa gac ctg aga tct gag tgc agc tct     1084
 Glu Asp Ile Pro Asn Lys Ile Glu Asp Leu Arg Ser Glu Cys Ser Ser
     140                 145                 150

 gat ttt ggg ggt aaa gat tct gtc act agt cca gac atg gat gaa ata     1132
 Asp Phe Gly Gly Lys Asp Ser Val Thr Ser Pro Asp Met Asp Glu Ile
 155                 160                 165                 170

 act cac ggt gcc cac cag ctg acc tct cct cct tct cag tca gag tct     1180
 Thr His Gly Ala His Gln Leu Thr Ser Pro Pro Ser Gln Ser Glu Ser
                 175                 180                 185

 ctg ctg gcc atg ttt gat cca ctg tct tca cat gaa ggg gct tct gct     1228
 Leu Leu Ala Met Phe Asp Pro Leu Ser Ser His Glu Gly Ala Ser Ala
             190                 195                 200

 gtg gta agg cca aag gtt cac tat gct agg cca tcg cat cca cca cca     1276
 Val Val Arg Pro Lys Val His Tyr Ala Arg Pro Ser His Pro Pro Pro
         205                 210                 215

 gat ccc cca atc ctg gaa gga gct gtg gga gga aat gag gcc agg ttg     1324
 Asp Pro Pro Ile Leu Glu Gly Ala Val Gly Gly Asn Glu Ala Arg Leu
     220                 225                 230

 cca aac ttt ggt tcc cat gtt tta act cca gct gaa atg gag gca ttc     1372
 Pro Asn Phe Gly Ser His Val Leu Thr Pro Ala Glu Met Glu Ala Phe
 235                 240                 245                 250

 aag caa agg cat tct tac cct gag aga cta gtt cga agc agg agc tct     1420
 Lys Gln Arg His Ser Tyr Pro Glu Arg Leu Val Arg Ser Arg Ser Ser
                 255                 260                 265

 gat ata gta tct tct gtc cgg aga ccc atg agt gac ccc agc tgg aac     1468
 Asp Ile Val Ser Ser Val Arg Arg Pro Met Ser Asp Pro Ser Trp Asn
             270                 275                 280

 cgg cgt cca gga aat gaa gag cga gaa ctc cct cca gct gca gcc att     1516
 Arg Arg Pro Gly Asn Glu Glu Arg Glu Leu Pro Pro Ala Ala Ala Ile
         285                 290                 295

 ggt gct act tct ttg gtg gct gca cct cat tca tca tct tca tcc ccg     1564
 Gly Ala Thr Ser Leu Val Ala Ala Pro His Ser Ser Ser Ser Ser Pro
     300                 305                 310

 agt aag gac tcc tca aga gga gag act gaa gaa cgc aaa gat agc gat     1612
 Ser Lys Asp Ser Ser Arg Gly Glu Thr Glu Glu Arg Lys Asp Ser Asp
 315                 320                 325                 330

 gat gag aaa tca gac agg aac aga cct tgg tgg aga aaa cgt ttt gtt     1660
 Asp Glu Lys Ser Asp Arg Asn Arg Pro Trp Trp Arg Lys Arg Phe Val
                 335                 340                 345

 tca gcc atg cct aaa gat gat ccc agc cct aga ctc agt gca caa gct     1708
 Ser Ala Met Pro Lys Asp Asp Pro Ser Pro Arg Leu Ser Ala Gln Ala
             350                 355                 360

 cag gtg gct gag gat att ctg gac aaa tac agg aat gcc att aaa cgg     1756
 Gln Val Ala Glu Asp Ile Leu Asp Lys Tyr Arg Asn Ala Ile Lys Arg
         365                 370                 375

 acc agc ccc agt gat gga gca atg gca aac tat gaa agt aca gag gtt     1804
 Thr Ser Pro Ser Asp Gly Ala Met Ala Asn Tyr Glu Ser Thr Glu Val
     380                 385                 390

 atg ggt gat ggt gaa agt gca cat gat tct ccc cgt gac gaa gca ctg     1852
 Met Gly Asp Gly Glu Ser Ala His Asp Ser Pro Arg Asp Glu Ala Leu
 395                 400                 405                 410

 cag aac atc tcg gct gat gat ctc cca gac tct gca agc caa gca gcc     1900
 Gln Asn Ile Ser Ala Asp Asp Leu Pro Asp Ser Ala Ser Gln Ala Ala
                 415                 420                 425

 cac ccg cag gat tca gct ttc tct tac aga gat gca aaa aag aaa ctg     1948
 His Pro Gln Asp Ser Ala Phe Ser Tyr Arg Asp Ala Lys Lys Lys Leu
             430                 435                 440

 agg ctt gct ctt tgc tct gcg gac tct gtt gcc ttc cca gtg ctg acc     1996
 Arg Leu Ala Leu Cys Ser Ala Asp Ser Val Ala Phe Pro Val Leu Thr
         445                 450                 455

 cat tca aca agg aat ggt tta cca gac cac aca gac cca gaa gac aat     2044
 His Ser Thr Arg Asn Gly Leu Pro Asp His Thr Asp Pro Glu Asp Asn
     460                 465                 470

 gaa att gta tgc ttc tta aaa gtt caa ata gct gaa gca att aat tta     2092
 Glu Ile Val Cys Phe Leu Lys Val Gln Ile Ala Glu Ala Ile Asn Leu
 475                 480                 485                 490

 caa gat aag aat cta atg gct caa ctt caa gaa aca atg cgc tgt gtg     2140
 Gln Asp Lys Asn Leu Met Ala Gln Leu Gln Glu Thr Met Arg Cys Val
                 495                 500                 505

 tgc cgt ttt gat aat agg act tgt agg aaa ctg ctg gct tcg att gct     2188
 Cys Arg Phe Asp Asn Arg Thr Cys Arg Lys Leu Leu Ala Ser Ile Ala
             510                 515                 520

 gag gac tac aga aaa aga gcc cca tat att gct tat ctc act cgt tgt     2236
 Glu Asp Tyr Arg Lys Arg Ala Pro Tyr Ile Ala Tyr Leu Thr Arg Cys
         525                 530                 535

 cga caa gga cta cag acc aca cag gct cac ctg gaa agg cta ttg caa     2284
 Arg Gln Gly Leu Gln Thr Thr Gln Ala His Leu Glu Arg Leu Leu Gln
     540                 545                 550

 aga gtt ttg cgg gac aaa gaa gtg gcc aat cga tac ttt acc act gtc     2332
 Arg Val Leu Arg Asp Lys Glu Val Ala Asn Arg Tyr Phe Thr Thr Val
 555                 560                 565                 570

 tgt gtg aga tta ctg ctt gag agc aaa gaa aag aag atc agg gaa ttc     2380
 Cys Val Arg Leu Leu Leu Glu Ser Lys Glu Lys Lys Ile Arg Glu Phe
                 575                 580                 585

 att caa gac ttt cag aaa ctc acc gca gct gac gat aaa act gct cag     2428
 Ile Gln Asp Phe Gln Lys Leu Thr Ala Ala Asp Asp Lys Thr Ala Gln
             590                 595                 600

 gta gaa gat ttt ctg cag ttt ctt tat ggt gca atg gcc cag gat gtc     2476
 Val Glu Asp Phe Leu Gln Phe Leu Tyr Gly Ala Met Ala Gln Asp Val
         605                 610                 615

 ata tgg caa aac gcg agt gaa gaa cag ctt caa gat gca cag ctg gcc     2524
 Ile Trp Gln Asn Ala Ser Glu Glu Gln Leu Gln Asp Ala Gln Leu Ala
     620                 625                 630

 att gag cga agc gtg atg aac cgg att ttc aag ctc gcc ttc tac cct     2572
 Ile Glu Arg Ser Val Met Asn Arg Ile Phe Lys Leu Ala Phe Tyr Pro
 635                 640                 645                 650

 aat caa gat ggg gac ata ctt cgc gac cag gtt ctt cat gaa cat atc     2620
 Asn Gln Asp Gly Asp Ile Leu Arg Asp Gln Val Leu His Glu His Ile
                 655                 660                 665

 cag aga ttg tct aaa gta gtg act gca aat cac aga gct ctt cag ata     2668
 Gln Arg Leu Ser Lys Val Val Thr Ala Asn His Arg Ala Leu Gln Ile
             670                 675                 680

 cca gag gtt tat ctt cga gaa gca cca tgg cca tct gca caa tca gaa     2716
 Pro Glu Val Tyr Leu Arg Glu Ala Pro Trp Pro Ser Ala Gln Ser Glu
         685                 690                 695

 atc agg aca ata agt gct tat aaa acc ccc cgg gac aaa gtg cag tgc     2764
 Ile Arg Thr Ile Ser Ala Tyr Lys Thr Pro Arg Asp Lys Val Gln Cys
     700                 705                 710

 atc ctg aga atg tgc tct acg att atg aac ctc ctg agc ctg gcc aat     2812
 Ile Leu Arg Met Cys Ser Thr Ile Met Asn Leu Leu Ser Leu Ala Asn
 715                 720                 725                 730

 gag gac tct gtc cct gga gcg gat gac ttt gtt cct gtg ttg gtg ttt     2860
 Glu Asp Ser Val Pro Gly Ala Asp Asp Phe Val Pro Val Leu Val Phe
                 735                 740                 745

 gtg ttg ata aag gca aat cca ccc tgt ttg ctg tct act gtg cag tat     2908
 Val Leu Ile Lys Ala Asn Pro Pro Cys Leu Leu Ser Thr Val Gln Tyr
             750                 755                 760

 atc agt agc ttt tat gct agc tgt ctg tct gga gag gag tcc tat tgg     2956
 Ile Ser Ser Phe Tyr Ala Ser Cys Leu Ser Gly Glu Glu Ser Tyr Trp
         765                 770                 775

 tgg atg cag ttc aca gca gca gta gaa ttc att aaa acc atc gat gac     3004
 Trp Met Gln Phe Thr Ala Ala Val Glu Phe Ile Lys Thr Ile Asp Asp
     780                 785                 790

 cga aag tga ccaagac caaggcccac caaggcagca gactgttaat cagacaaaca     3060
 Arg Lys 
 795

 gatctctgag aaggtgcatc agctgctttg aaggctgaag attgttttgt atgatactgc   3120

 acagcatcag gcattttaaa gcagatcttt actaaacagg ttaatgagct aacaaaaaaa   3180

 aaaaa                                                               3185




      <210> 92
      <211> 1607
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (148)..(1152)

      <220>
      <221> misc_feature
      <222> (1)...(1607)
      <223> n = a,t,c or g

      <400> 92
 ctcgcgaatg ttaggcctgt gggtgccata gcgaccggga ggttgggctg gccagattca     60

 gctgccggga ccggaccagg tgcttaggag aacatgcagt agaacttttc atcaaacaaa    120

 tggaacacgt cacagaattt tgctaac    atg gac aac tct gca cag aaa aat     171
                                  Met Asp Asn Ser Ala Gln Lys Asn
                                    1               5

 gaa cgc act ggc aaa cat ccc aga cgt gcc agt gaa gta cag aaa ggt      219
 Glu Arg Thr Gly Lys His Pro Arg Arg Ala Ser Glu Val Gln Lys Gly
      10                  15                  20

 ttt act gct gca tat cca aca caa tcc tcc att cct ttt aaa tct caa      267
 Phe Thr Ala Ala Tyr Pro Thr Gln Ser Ser Ile Pro Phe Lys Ser Gln
  25                  30                  35                  40

 gct tca gta atc cca gaa tca gaa aaa aaa gga ttc aat agt caa gcc      315
 Ala Ser Val Ile Pro Glu Ser Glu Lys Lys Gly Phe Asn Ser Gln Ala
                  45                  50                  55

 aag aga ttt cct cat aag aag aat gat atc cca gga cct ggg ttc tac      363
 Lys Arg Phe Pro His Lys Lys Asn Asp Ile Pro Gly Pro Gly Phe Tyr
              60                  65                  70

 aat gtt att cac cag tca ccg gtg tcc aac agt gtc tca ttg tcc aag      411
 Asn Val Ile His Gln Ser Pro Val Ser Asn Ser Val Ser Leu Ser Lys
          75                  80                  85

 aaa gga act tgc atg ttt ccc tca atg tgc gcc cga ttg gac acc atc      459
 Lys Gly Thr Cys Met Phe Pro Ser Met Cys Ala Arg Leu Asp Thr Ile
      90                  95                 100

 att tct aaa tac cct gca gcg aat gca tac act atc cca tcg gat ttt      507
 Ile Ser Lys Tyr Pro Ala Ala Asn Ala Tyr Thr Ile Pro Ser Asp Phe
 105                 110                 115                 120

 att tcc aag aga gac ttt agt aat tcg tgt tcc agc atg ttc cag ttg      555
 Ile Ser Lys Arg Asp Phe Ser Asn Ser Cys Ser Ser Met Phe Gln Leu
                 125                 130                 135

 cca agc ttt atg aaa gct ctc aag ttt gaa act cct gca cca aac tat      603
 Pro Ser Phe Met Lys Ala Leu Lys Phe Glu Thr Pro Ala Pro Asn Tyr
             140                 145                 150

 tac aat gcc tct gtc tct tgc tgc aag cag aga aac aac gtc tgt act      651
 Tyr Asn Ala Ser Val Ser Cys Cys Lys Gln Arg Asn Asn Val Cys Thr
         155                 160                 165

 cga gcc ggg ttt atg tca aaa acc caa aga gga tct ttc gct ttt gct      699
 Arg Ala Gly Phe Met Ser Lys Thr Gln Arg Gly Ser Phe Ala Phe Ala
     170                 175                 180

 gat aaa gga cct ccc cca ggg cat tat gat atc aac gaa tcc ctt gtg      747
 Asp Lys Gly Pro Pro Pro Gly His Tyr Asp Ile Asn Glu Ser Leu Val
 185                 190                 195                 200

 aag cag tcg cca aat aca tta atg tct tgt ttt aaa tca aaa acc aac      795
 Lys Gln Ser Pro Asn Thr Leu Met Ser Cys Phe Lys Ser Lys Thr Asn
                 205                 210                 215

 cgt gga tta aaa ctg acg tca aca ggc ccg gga cct ggt tat tac aac      843
 Arg Gly Leu Lys Leu Thr Ser Thr Gly Pro Gly Pro Gly Tyr Tyr Asn
             220                 225                 230

 ccc agt gat tgc aca aaa gtt cca aaa aag act ctt ttc ccg aaa aac      891
 Pro Ser Asp Cys Thr Lys Val Pro Lys Lys Thr Leu Phe Pro Lys Asn
         235                 240                 245

 ccc atc ctg aac ttc tct gct cag cct tcg cct ctg cct ccg aag cca      939
 Pro Ile Leu Asn Phe Ser Ala Gln Pro Ser Pro Leu Pro Pro Lys Pro
     250                 255                 260

 cct ttc cca ggt cct ggt cag tat gag atc gtg gac tac tta ggc ccc      987
 Pro Phe Pro Gly Pro Gly Gln Tyr Glu Ile Val Asp Tyr Leu Gly Pro
 265                 270                 275                 280

 cgc aag cat ttc atc tct agt gca tca ttc gtg tcc aat acc agc cgg     1035
 Arg Lys His Phe Ile Ser Ser Ala Ser Phe Val Ser Asn Thr Ser Arg
                 285                 290                 295

 tgg aca gcg gcg ccg cct cag cca ggc ctg cct ggc cca gct acg tac     1083
 Trp Thr Ala Ala Pro Pro Gln Pro Gly Leu Pro Gly Pro Ala Thr Tyr
             300                 305                 310

 aag cca gag ctt cca gga aag cag tcc ttc ctc tac aac gag gac aag     1131
 Lys Pro Glu Leu Pro Gly Lys Gln Ser Phe Leu Tyr Asn Glu Asp Lys
         315                 320                 325

 aaa tgg atc ccg gtt ctg tag gg atgtcacaca aggtcaagga gaactccagc     1184
 Lys Trp Ile Pro Val Leu 
     330

 caccagccca ccctgcccag cgtccccagg acattcctca ggaggagacc gatcatgagt   1244

 gtggcagctg aacttggggg gtggctctac cactctggcc tggcatccta gccggactgc   1304

 tgccattgcc tttgtcttga gctggagaca ttgctccctg gagacttcac cccagcccca   1364

 cagactccag tggcttcntg agcagaaggg aggagtggac agagccccct ggctgcttcc   1424

 ccacgcaccc atccaggctg ccttccggca cgactccctg ccgcagactg aagggactcc   1484

 tgaagcgcag acttcaagga ggatcagtcc accctgaagg tggccaagcc tggaagcccc   1544

 acccttccct gtttcattcc ttcattcatt tacacattca ttcattccct caaaaaaaaa   1604

 aaa                                                                 1607




      <210> 93
      <211> 1316
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (107)..(1078)

      <400> 93
 gggctgcctg tgacgcgcgg cgcggtcggt cctgcctgta acggcggcgg cggctgctgc     60

 tccagacacc tgcggcggcg gcggcgaccc cgcggcgggc gcggag   atg tgg ccc     115
                                                      Met Trp Pro
                                                        1

 ctg gta gcg gcg ctg ttg ctg ggc tcg gcg tgc tgc gga tca gct cag      163
 Leu Val Ala Ala Leu Leu Leu Gly Ser Ala Cys Cys Gly Ser Ala Gln
       5                  10                  15

 cta cta ttt aat aaa aca aaa tct gta gaa ttc acg ttt tgt aat gac      211
 Leu Leu Phe Asn Lys Thr Lys Ser Val Glu Phe Thr Phe Cys Asn Asp
  20                  25                  30                  35

 act gtc gtc att cca tgc ttt gtt act aat atg gag gca caa aac act      259
 Thr Val Val Ile Pro Cys Phe Val Thr Asn Met Glu Ala Gln Asn Thr
                  40                  45                  50

 act gaa gta tac gta aag tgg aaa ttt aaa gga aga gat att tac acc      307
 Thr Glu Val Tyr Val Lys Trp Lys Phe Lys Gly Arg Asp Ile Tyr Thr
              55                  60                  65

 ttt gat gga gct cta aac aag tcc act gtc ccc act gac ttt agt agt      355
 Phe Asp Gly Ala Leu Asn Lys Ser Thr Val Pro Thr Asp Phe Ser Ser
          70                  75                  80

 gca aaa att gaa gtc tca caa tta cta aaa gga gat gcc tct ttg aag      403
 Ala Lys Ile Glu Val Ser Gln Leu Leu Lys Gly Asp Ala Ser Leu Lys
      85                  90                  95

 atg gat aag agt gat gct gtc tca cac aca gga aac tac act tgt gaa      451
 Met Asp Lys Ser Asp Ala Val Ser His Thr Gly Asn Tyr Thr Cys Glu
 100                 105                 110                 115

 gta aca gaa tta acc aga gaa ggt gaa acg atc atc gag cta aaa tat      499
 Val Thr Glu Leu Thr Arg Glu Gly Glu Thr Ile Ile Glu Leu Lys Tyr
                 120                 125                 130

 cgt gtt gtt tca tgg ttt tct cca aat gaa aat att ctt att gtt att      547
 Arg Val Val Ser Trp Phe Ser Pro Asn Glu Asn Ile Leu Ile Val Ile
             135                 140                 145

 ttc cca att ttt gct ata ctc ctg ttc tgg gga cag ttt ggt att aaa      595
 Phe Pro Ile Phe Ala Ile Leu Leu Phe Trp Gly Gln Phe Gly Ile Lys
         150                 155                 160

 aca ctt aaa tat aga tcc ggt ggt atg gat gag aaa aca att gct tta      643
 Thr Leu Lys Tyr Arg Ser Gly Gly Met Asp Glu Lys Thr Ile Ala Leu
     165                 170                 175

 ctt gtt gct gga cta gtg atc act gtc att gtc att gtt gga gcc att      691
 Leu Val Ala Gly Leu Val Ile Thr Val Ile Val Ile Val Gly Ala Ile
 180                 185                 190                 195

 ctt ttc gtc cca ggt gaa tat tca tta aag aat gct act ggc ctt ggt      739
 Leu Phe Val Pro Gly Glu Tyr Ser Leu Lys Asn Ala Thr Gly Leu Gly
                 200                 205                 210

 tta att gtg act tct aca ggg ata tta ata tta ctt cac tac tat gtg      787
 Leu Ile Val Thr Ser Thr Gly Ile Leu Ile Leu Leu His Tyr Tyr Val
             215                 220                 225

 ttt agt aca gcg att gga tta acc tcc ttc gtc att gcc ata ttg gtt      835
 Phe Ser Thr Ala Ile Gly Leu Thr Ser Phe Val Ile Ala Ile Leu Val
         230                 235                 240

 att cag gtg ata gcc tat atc ctc gct gtg gtt gga ctg agt ctc tgt      883
 Ile Gln Val Ile Ala Tyr Ile Leu Ala Val Val Gly Leu Ser Leu Cys
     245                 250                 255

 att gcg gcg tgt ata cca atg cat ggc cct ctt ctg att tca ggt ttg      931
 Ile Ala Ala Cys Ile Pro Met His Gly Pro Leu Leu Ile Ser Gly Leu
 260                 265                 270                 275

 agt atc tta gct cta gca caa tta ctt gga cta gtt tat atg aaa ttt      979
 Ser Ile Leu Ala Leu Ala Gln Leu Leu Gly Leu Val Tyr Met Lys Phe
                 280                 285                 290

 gtg gct tcc aat cag aag act ata caa cct cct agg aaa gct gta gag     1027
 Val Ala Ser Asn Gln Lys Thr Ile Gln Pro Pro Arg Lys Ala Val Glu
             295                 300                 305

 gaa ccc ctt aat gca ttc aaa gaa tca aaa gga atg atg aat gat gaa     1075
 Glu Pro Leu Asn Ala Phe Lys Glu Ser Lys Gly Met Met Asn Asp Glu
         310                 315                 320

 taa ctga agtgaagtga tggactccga tttggagagt agtaagacgt gaaaggaata     1132
 


 cacttgtgtt taagcaccat ggccttgatg attcactgtt ggggagaaga aacaagaaaa   1192

 gtaactggtt gtcacctatg agacccttac gtgattgtta gttaagtttt tattcaaagc   1252

 agctgtaatt tagttaataa aataattatg atctatgttg tttgcccaat tgaaaaaaaa   1312

 aaaa                                                                1316




      <210> 94
      <211> 4415
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (97)..(2109)

      <400> 94
 gcacgagcgg cggcggcggc ggcagtggcg gtcccactgg caggcgggca agaggggagt     60

 ccgggcggcg gccggcgtgg gagccggggg accacc  atg gta aag aag cgg aaa     114
                                          Met Val Lys Lys Arg Lys
                                            1               5

 ggc cgc gtc gtg atc gac tcg gac aca gag gac agc ggc agc gac gag      162
 Gly Arg Val Val Ile Asp Ser Asp Thr Glu Asp Ser Gly Ser Asp Glu
              10                  15                  20

 aac ctg gat cag gag ctc ttg tcc ctg gca aag cga aag cgc agt gac      210
 Asn Leu Asp Gln Glu Leu Leu Ser Leu Ala Lys Arg Lys Arg Ser Asp
          25                  30                  35

 tct gag gag aag gag ccg cct gtg agt cag cct gca gcc tcg tca gac      258
 Ser Glu Glu Lys Glu Pro Pro Val Ser Gln Pro Ala Ala Ser Ser Asp
      40                  45                  50

 tcg gag acg tct gac agt gac gat gag tgg aca ttt ggg agc aat aaa      306
 Ser Glu Thr Ser Asp Ser Asp Asp Glu Trp Thr Phe Gly Ser Asn Lys
  55                  60                  65                  70

 aat aag aag aaa gga aaa gcc aga aaa ata gag aag aaa gga acc atg      354
 Asn Lys Lys Lys Gly Lys Ala Arg Lys Ile Glu Lys Lys Gly Thr Met
                  75                  80                  85

 aag aaa cag gcc aac aaa act gcc tcc tca ggc agt tca gac aaa gac      402
 Lys Lys Gln Ala Asn Lys Thr Ala Ser Ser Gly Ser Ser Asp Lys Asp
              90                  95                 100

 agt tca gct gag agc tca gcc cct gag gaa ggt gaa gtg tca gac tct      450
 Ser Ser Ala Glu Ser Ser Ala Pro Glu Glu Gly Glu Val Ser Asp Ser
         105                 110                 115

 gac agc aac agc tcc tct tcc agt tca gat tca gac tct tcc tca gaa      498
 Asp Ser Asn Ser Ser Ser Ser Ser Ser Asp Ser Asp Ser Ser Ser Glu
     120                 125                 130

 gat gaa gag ttc cat gat ggc tat gga gaa gac ctc atg gga gat gag      546
 Asp Glu Glu Phe His Asp Gly Tyr Gly Glu Asp Leu Met Gly Asp Glu
 135                 140                 145                 150

 gaa gac agg gcc cgt ctg gaa cag atg aca gag aaa gag aga gag caa      594
 Glu Asp Arg Ala Arg Leu Glu Gln Met Thr Glu Lys Glu Arg Glu Gln
                 155                 160                 165

 gaa ctg ttc aat cgc ata gag aag agg gag gtg ttg aaa aga aga ttt      642
 Glu Leu Phe Asn Arg Ile Glu Lys Arg Glu Val Leu Lys Arg Arg Phe
             170                 175                 180

 gaa atc aag aaa aaa cta aaa aca gcc aaa aag aaa gaa aag aaa gaa      690
 Glu Ile Lys Lys Lys Leu Lys Thr Ala Lys Lys Lys Glu Lys Lys Glu
         185                 190                 195

 aag aag aaa aag caa gaa gag gag caa gaa aag aaa aaa ctg aca cag      738
 Lys Lys Lys Lys Gln Glu Glu Glu Gln Glu Lys Lys Lys Leu Thr Gln
     200                 205                 210

 att caa gaa tct cag gta aca tcc cac aac aag gaa cgg cgt tcc aag      786
 Ile Gln Glu Ser Gln Val Thr Ser His Asn Lys Glu Arg Arg Ser Lys
 215                 220                 225                 230

 cgg gat gag aaa cta gac aag aaa tct caa gcc atg gag gag cta aaa      834
 Arg Asp Glu Lys Leu Asp Lys Lys Ser Gln Ala Met Glu Glu Leu Lys
                 235                 240                 245

 gca gag cga gaa aaa cga aag aac aga aca gct gag ctc ctt gcc aaa      882
 Ala Glu Arg Glu Lys Arg Lys Asn Arg Thr Ala Glu Leu Leu Ala Lys
             250                 255                 260

 aaa cag cca tta aaa acc agt gag gtc tac tct gat gat gaa gag gag      930
 Lys Gln Pro Leu Lys Thr Ser Glu Val Tyr Ser Asp Asp Glu Glu Glu
         265                 270                 275

 gaa gag gat gac aaa tcc agt gaa aag tca gac cgc tca tca cga aca      978
 Glu Glu Asp Asp Lys Ser Ser Glu Lys Ser Asp Arg Ser Ser Arg Thr
     280                 285                 290

 tca tcg tct gat gaa gaa gag gag aaa gaa gag atc cct ccc aaa tcc     1026
 Ser Ser Ser Asp Glu Glu Glu Glu Lys Glu Glu Ile Pro Pro Lys Ser
 295                 300                 305                 310

 caa cca gtt tcc tta cct gaa gaa ttg aat cgg gtt cga tta tca cgg     1074
 Gln Pro Val Ser Leu Pro Glu Glu Leu Asn Arg Val Arg Leu Ser Arg
                 315                 320                 325

 cat aag cta gaa cgc tgg tgt cac atg ccc ttc ttt gct aaa act gtc     1122
 His Lys Leu Glu Arg Trp Cys His Met Pro Phe Phe Ala Lys Thr Val
             330                 335                 340

 aca gga tgt ttt gtg cgg att ggc atc gga aac cac aac agc aaa cca     1170
 Thr Gly Cys Phe Val Arg Ile Gly Ile Gly Asn His Asn Ser Lys Pro
         345                 350                 355

 gtt tac cgg gtc gct gag att acg ggt gtt gtg gaa act gcc aaa gtt     1218
 Val Tyr Arg Val Ala Glu Ile Thr Gly Val Val Glu Thr Ala Lys Val
     360                 365                 370

 tac caa cta ggt ggc acc aga aca aac aaa ggg ctg caa cta cgg cat     1266
 Tyr Gln Leu Gly Gly Thr Arg Thr Asn Lys Gly Leu Gln Leu Arg His
 375                 380                 385                 390

 ggc aat gac caa cgc gtg ttc cgt tta gag ttt gtc tca aac caa gaa     1314
 Gly Asn Asp Gln Arg Val Phe Arg Leu Glu Phe Val Ser Asn Gln Glu
                 395                 400                 405

 ttc acc gaa agt gag ttt atg aag tgg aaa gaa gcg atg ttc tct gct     1362
 Phe Thr Glu Ser Glu Phe Met Lys Trp Lys Glu Ala Met Phe Ser Ala
             410                 415                 420

 ggc atg cag ttg ccc act cta gat gaa atc aat aaa aag gaa tta tct     1410
 Gly Met Gln Leu Pro Thr Leu Asp Glu Ile Asn Lys Lys Glu Leu Ser
         425                 430                 435

 att aaa gaa gct ctt aat tat aaa ttc aat gat cag gac att gaa gag     1458
 Ile Lys Glu Ala Leu Asn Tyr Lys Phe Asn Asp Gln Asp Ile Glu Glu
     440                 445                 450

 att gta aaa gag aaa gaa agg ttc aga aaa gct cca ccc aac tac gct     1506
 Ile Val Lys Glu Lys Glu Arg Phe Arg Lys Ala Pro Pro Asn Tyr Ala
 455                 460                 465                 470

 atg aag aag act cag cta ctg aag gaa aag gcc atg gct gag gac ctg     1554
 Met Lys Lys Thr Gln Leu Leu Lys Glu Lys Ala Met Ala Glu Asp Leu
                 475                 480                 485

 ggg gat cag gac aag gcc aaa caa atc caa gat caa ctg aat gag ctg     1602
 Gly Asp Gln Asp Lys Ala Lys Gln Ile Gln Asp Gln Leu Asn Glu Leu
             490                 495                 500

 gag gaa cgg gca gag gcc ctg gac cgc cag cgg acc aag aac ata tcc     1650
 Glu Glu Arg Ala Glu Ala Leu Asp Arg Gln Arg Thr Lys Asn Ile Ser
         505                 510                 515

 gct atc agt tac atc aac cag cgg aac cgg gag tgg aac att gta gag     1698
 Ala Ile Ser Tyr Ile Asn Gln Arg Asn Arg Glu Trp Asn Ile Val Glu
     520                 525                 530

 tct gag aag gcc ctt gtg gct gaa agt cac aac atg aaa aac caa cag     1746
 Ser Glu Lys Ala Leu Val Ala Glu Ser His Asn Met Lys Asn Gln Gln
 535                 540                 545                 550

 atg gat ccc ttt act cgg cgg cag tgc aag cct acc atc gtt tct aat     1794
 Met Asp Pro Phe Thr Arg Arg Gln Cys Lys Pro Thr Ile Val Ser Asn
                 555                 560                 565

 tcc aga gac cca gct gtt caa gct gcc atc ttg gcc cag ctg aat gca     1842
 Ser Arg Asp Pro Ala Val Gln Ala Ala Ile Leu Ala Gln Leu Asn Ala
             570                 575                 580

 aaa tac ggt tct gga gtg tta cca gat gct cca aag gaa atg agc aag     1890
 Lys Tyr Gly Ser Gly Val Leu Pro Asp Ala Pro Lys Glu Met Ser Lys
         585                 590                 595

 ggt caa ggc aaa gat aaa gat ttg aat tct aag tca gcc agt gac ctc     1938
 Gly Gln Gly Lys Asp Lys Asp Leu Asn Ser Lys Ser Ala Ser Asp Leu
     600                 605                 610

 tca gaa gat ctg ttc aaa gta cac gat ttt gat gtg aag att gac tta     1986
 Ser Glu Asp Leu Phe Lys Val His Asp Phe Asp Val Lys Ile Asp Leu
 615                 620                 625                 630

 caa gtt ccc agc tca gag tca aag gct tta gcc atc acc tcc aag gct     2034
 Gln Val Pro Ser Ser Glu Ser Lys Ala Leu Ala Ile Thr Ser Lys Ala
                 635                 640                 645

 ccg cca gcc aag gat ggg gct cca agg aga tct ctg aac ttg gaa gac     2082
 Pro Pro Ala Lys Asp Gly Ala Pro Arg Arg Ser Leu Asn Leu Glu Asp
             650                 655                 660

 tac aaa aaa cga cga ggg ctt att tga gcaca cccagcctgc tgcttctgac     2134
 Tyr Lys Lys Arg Arg Gly Leu Ile 
         665                 670

 cctgcatgcc ccatcgcagc gtcccacctt tcctcctttc ctttgattta gcctctttgg   2194

 gctggagcag ctgttgaact gggaagagac tctaaactgc cagtcatctg taatataaac   2254

 catttgctgt atagacctcc tttgtctgca caccatctcc caccagcctc ccctccccca   2314

 gggccccacc cagtgtgggc ctgggctctc ttgggcttta tccatgtctt tagatttgtg   2374

 tttgcctttt gtttttttaa ccgcgcagtt cattggccac tctgcacgca ttcagtatta   2434

 ccatggagct gggaatcttg ctggagcccc tggggcaata gcagcagcac caggcggtct   2494

 cctctacaga ctgccttggc ccacccattg aacattcggc acgtgacctt gtggggggag   2554

 cggggattgg gcacctgcga tcctctttcc tctcttcatc tttctcttct gcccttcttt   2614

 ttggaagaag gggtttcaaa accagtttag tttccaaaaa gtgtacattt gtgggggggg   2674

 ggggtctaat ttgagagcga gagtgtgtat gtgtgtgtgt gtaagtgtgt ggattttttt   2734

 atcatttttt taaaatgcag tactctttgt atcagtctgt catgggtcta tagctgtttc   2794

 agattttttt cagctgtact tgagcatctg aaactgcaag aaagaaactc attaaatgtg   2854

 attcttctta ctaaacaggc ctgactgctg tagctgtgta acttccccat tcccacctac   2914

 tcttcccatc ctttcccaac tttggagaaa actccccagt ttagccccct gacctgcagg   2974

 ctgtgtcctg gcaggtgtgg gagggaagcc catggccagg taccagggag ggcagtgaat   3034

 gtcttgctct tcccatgggt acagcccaca gcttcttggc tgaacgtaga acttcttttt   3094

 ctcacccagt ataccagcct cttcctggtg attctgtttt gctgctttgg caagaactac   3154

 attttgtttt taagagaaat ttctgaatat gaatgtggag agcaaacaca aaaagattta   3214

 ggttacgccg ggtgcagtag ctcacgcctg taatcccagc actttgggag gcctaggcgg   3274

 gtggatcacc tgaggtcagg agttcaagac caatctgact aacacggtga aaccccatct   3334

 ctactaaaac tacaaaactt agccgggcat ggtggtgcgt gcctgtaatc ccagctactc   3394

 ggggggctga gacaggagaa tcccttgaac ctgggaggcg gaggttgtgg tgagccaaga   3454

 tcgtgccact gcactccagt ctgggtgaca gagtgagact ccgcctcaaa aagatttagg   3514

 ttgcaaatgt ttcaagcatg tgcagttttg tgtgtgtgta tacatatata tggtcagcat   3574

 atatattgtg cagctagggc gaagccagca gaggtgtgtg tatgtcttta tgaaatgttt   3634

 gaaaagagat aaactgactg cttgataatc actctcaggt gtaaagctcc aagtgtaaat   3694

 aaaagtggca tttaacaaat ctttcagaac aaagtacagc tgactatata taccaagagc   3754

 taagctaaag gaacagctga gagctccgat ctccacgaga gactaatcta aaagctctgc   3814

 tttgtacttc ctcaccctgc tttcgtacaa ggaaggggga cgatgggaaa tcatggactt   3874

 gtaagttgta tttaaacata aaaatgaact tggtaacttc tgggtttagt agagcctcag   3934

 tgtcgcttta acttagttta cttttttttt atttttaaag cagcaatgga tggttttaaa   3994

 ggagtattat gattgtaaaa ttgctaaata tgactgtaac acagctttgt ggtagctgtg   4054

 acacagttca cttgggcaaa ggagtggtga tggactcgtt aaaatcatat atacttgaat   4114

 agtccattga ccgaaactct ttatagacta ttgtgtaaat gtggaatcac agactgttaa   4174

 cattgcctgg acttcagcag agtcctggag ctgctgggac ctctcctatc atgatgaact   4234

 tggacttttt tttttgattt ctggttttaa aaaacataaa attatagaat ccagataatt   4294

 cgctggagtc attctgatcc accatgtaga tctgtattta gtatcatttg gatttggaga   4354

 agtgttgatt acattatggc tgtgtaataa aatttttatt aaaactgcaa aaaaaaaaaa   4414

 a                                                                   4415




      <210> 95
      <211> 1926
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (797)..(1573)

      <400> 95
 gctagggagc tccccagaga gaacatgagg aggaggcttt ttaggacaaa tagataaaag     60

 caaagataat atttcattgg ttacagttat acagttacac agttatacag ttgccttatt    120

 tggtctatcc catgaggaag tcctagttac taattacgtt tttgttggct gcttctgatt    180

 ggttgagctt aagttctgtg tttctttaac ataggcattt acaagaaata ccacaaataa    240

 agtttcagac atgcttgcaa atcaagcaag gttaaggtca cttaggaggc ccaactggct    300

 ctgtctgctc aaggattctt ctggcctcgt ctccatttta catgaactgt tgcataaata    360

 aacacagagt acctgaaaca acggaggtga tcattctgcc taccgagtgt tggccaggcc    420

 aagcttggag tgttgctctt attcttaggg agtttatttt taagtaatct catctgtaaa    480

 tgggattaca atccacaaac tgaccttgta tatgattcca ttccttctcc cagcccagcc    540

 ccacactcca aggttttccc tttgcttata aggggtagtc accctttttt atttcgacct    600

 tccaaacatt ctgggagttt tcctccttta ggccaactac agcgcagagg agcgctttct    660

 cctgctgggt ttctccgact ggccttccct gcagccggtc ctcttcgccc ttgtcctcct    720

 gtgctacctc ctgaccttga cgggcaactc ggcgctggtg ctgctggcgg tgcgcgaccc    780

 gcgcctgcac acgccc    atg tac tac ttc ctc tgc cac ctg gcc ttg gta     829
                      Met Tyr Tyr Phe Leu Cys His Leu Ala Leu Val
                        1               5                  10

 gac gcg ggc ttc act act agc gtg gtg ccg ccg ctg ctg gcc aac ctg      877
 Asp Ala Gly Phe Thr Thr Ser Val Val Pro Pro Leu Leu Ala Asn Leu
              15                  20                  25

 cgc gga cca gcg ctc tgg ctg ccg cgc agc cac tgc acg gcc cag ctg      925
 Arg Gly Pro Ala Leu Trp Leu Pro Arg Ser His Cys Thr Ala Gln Leu
          30                  35                  40

 tgc gca tcg ctg gct ctg ggt tcg gcc gaa tgc gtc ctc ctg gcg gtg      973
 Cys Ala Ser Leu Ala Leu Gly Ser Ala Glu Cys Val Leu Leu Ala Val
      45                  50                  55

 atg gct ctg gac cgc gcg gcc gca gtg tgc cgc ccg ctg cgc tat gcg     1021
 Met Ala Leu Asp Arg Ala Ala Ala Val Cys Arg Pro Leu Arg Tyr Ala
  60                  65                  70                  75

 ggg ctc gtc tcc ccg cgc cta tgt cgc acg ctg gcc agc gcc tcc tgg     1069
 Gly Leu Val Ser Pro Arg Leu Cys Arg Thr Leu Ala Ser Ala Ser Trp
                  80                  85                  90

 cta agc ggc ctc acc aac tcg gtt gcg caa acc gcg ctc ctg gct gag     1117
 Leu Ser Gly Leu Thr Asn Ser Val Ala Gln Thr Ala Leu Leu Ala Glu
              95                 100                 105

 cgg ccg ctg tgc gcg ccc cgc ctg ctg gac cac ttc atc tgt gag ctg     1165
 Arg Pro Leu Cys Ala Pro Arg Leu Leu Asp His Phe Ile Cys Glu Leu
         110                 115                 120

 ccg gcg ttg ctc aag ctg gcc tgc gga ggc gac gga gac act acc gag     1213
 Pro Ala Leu Leu Lys Leu Ala Cys Gly Gly Asp Gly Asp Thr Thr Glu
     125                 130                 135

 aac cag atg ttc gcc gcc cgc gtg gtc atc ctg ctg ctg ccg ttt gcc     1261
 Asn Gln Met Phe Ala Ala Arg Val Val Ile Leu Leu Leu Pro Phe Ala
 140                 145                 150                 155

 gtc atc ctg gcc tcc tac ggt gcc gtg gcc cga gct gtc tgt tgc atg     1309
 Val Ile Leu Ala Ser Tyr Gly Ala Val Ala Arg Ala Val Cys Cys Met
                 160                 165                 170

 cgg ttc agc gga ggc cgg agg agg gcg gtg ggc acg tgt ggg tcc cac     1357
 Arg Phe Ser Gly Gly Arg Arg Arg Ala Val Gly Thr Cys Gly Ser His
             175                 180                 185

 ctg aca gcc gtc tgc ctg ttc tac ggc tcg gcc atc tac acc tac ctg     1405
 Leu Thr Ala Val Cys Leu Phe Tyr Gly Ser Ala Ile Tyr Thr Tyr Leu
         190                 195                 200

 cag ccc gcg cag cgc tac aac cag gca cgg ggc aag ttc gta tcg ctc     1453
 Gln Pro Ala Gln Arg Tyr Asn Gln Ala Arg Gly Lys Phe Val Ser Leu
     205                 210                 215

 ttc tac acc gtg gtc aca cct gct ctc aac ccg ctc atc tac acc ctc     1501
 Phe Tyr Thr Val Val Thr Pro Ala Leu Asn Pro Leu Ile Tyr Thr Leu
 220                 225                 230                 235

 agg aat aag aaa gtg aag ggg gca gcg agg agg ctg ctg cgg agt ctg     1549
 Arg Asn Lys Lys Val Lys Gly Ala Ala Arg Arg Leu Leu Arg Ser Leu
                 240                 245                 250

 ggg aga ggc cag gct ggg cag tga gtagttgggg aggggagaaa gtattaagcc    1603
 Gly Arg Gly Gln Ala Gly Gln 
             255

 agaacccaag gatggaaata ccccttagtg agtcagttta gacttcaggc tgttcatttt   1663

 tgtatgataa tctgcaagat ttgtcctaag gagtccaatg ggggatatgt tttcctcccg   1723

 tgaggaaatg tttagttctt gagggaaaat ccctaaatcc tctatatact caggtttagg   1783

 gaaggaaaac ctacccctca caactccacg cgcagggaaa atgatggaag tgacgctcgc   1843

 ctttagcttc ctccctatct gatggaagac catggaagac ctcttggtct ctgcaatcag   1903

 aagtctcaag ttgacaagaa aat                                           1926




      <210> 96
      <211> 849
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (532)..(849)

      <400> 96
 ccattcttac aggagtaagg tggtatcata ttgtgctttt gatttgcatt tcccagatca     60

 cagctattta aaacaaaaca aaaacctaaa tttaaaggcc tggaataaat cttaggccta    120

 ccattatctt cctcaaacta gttcaagttc tttagttcat ttctatttca caaagatgtt    180

 taccaacatt actgactcaa acagactatg gtcaatccag tcattttctc actctgccat    240

 ctgtcaaaac aagttgattt ttgctcacta gagaacatat tcataatgca gcaaaataaa    300

 cttgtatgca gcttattttc ggaagtttaa attttattac tactttttaa acacagggct    360

 gcatttgaca tgtttacact cattcccagt gatttccagc agtggacagt aaagtcattt    420

 agaaatttga ctgcaagcaa attattacca tgccaaacta ttaaaacaca ttattgactg    480

 attgactgac aaggtctctg tcacccaagc tgggagcaca gcagcacaat c atg gct     537
                                                          Met Ala
                                                            1

 cac tgc agc ctt gac ctc tcg ggt tca ggt gat cct ccc acc tca acc      585
 His Cys Ser Leu Asp Leu Ser Gly Ser Gly Asp Pro Pro Thr Ser Thr
           5                  10                  15

 tcc caa gta gct agg act ata ggt gca tgc cat cac gtc cag cta att      633
 Ser Gln Val Ala Arg Thr Ile Gly Ala Cys His His Val Gln Leu Ile
      20                  25                  30

 ttt gta ttt ttc gga gag aca ggg ttt cac cat gtt gcc cca cta gtc      681
 Phe Val Phe Phe Gly Glu Thr Gly Phe His His Val Ala Pro Leu Val
  35                  40                  45                  50

 ttg gaa ctc ctg gac tca agt gat cca cct acc ttg gcc tcc cag agt      729
 Leu Glu Leu Leu Asp Ser Ser Asp Pro Pro Thr Leu Ala Ser Gln Ser
                  55                  60                  65

 ggt ggg aac agg cat gag cca cca cac agg gcc cta aaa cac att ttt      777
 Gly Gly Asn Arg His Glu Pro Pro His Arg Ala Leu Lys His Ile Phe
              70                  75                  80

 tta aaa cac att tgg cta ttt agt ttt tat ttt cac caa aat gga cat      825
 Leu Lys His Ile Trp Leu Phe Ser Phe Tyr Phe His Gln Asn Gly His
          85                  90                  95

 gag gaa act atg gat cag ata taa                                      849
 Glu Glu Thr Met Asp Gln Ile 
     100                 105





      <210> 97
      <211> 1470
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (256)..(1470)

      <400> 97
 actgcactcc agcctgtaat ttcagctacc cttgaggctg aggcaggaga atcactggag     60

 cctgggaggt ggaagttgca gtgaaccaag atggtgccaa cacactccag cttgggcaac    120

 agagccagac ttcatccttg aggccgttca gttgtaataa acttgcacag gggaggtagt    180

 tgggaagggc caggagaact tcccctaata taggagacga caggctcatc gctgggcatc    240

 agcatccgca caaca atg gtg cca ttc tct ctc ggg gag gtg atg acg gtc     291
                  Met Val Pro Phe Ser Leu Gly Glu Val Met Thr Val
                    1               5                  10

 cct cgc gcc gga ggg ccc agg gag gaa aga gat aag cag aaa gac acc      339
 Pro Arg Ala Gly Gly Pro Arg Glu Glu Arg Asp Lys Gln Lys Asp Thr
          15                  20                  25

 agg gaa gaa cac cac gct tcg gac caa cgc cag cca cag cca ctg aga      387
 Arg Glu Glu His His Ala Ser Asp Gln Arg Gln Pro Gln Pro Leu Arg
      30                  35                  40

 agt cgc cgc atc cgg cgg cgc cga cac acg ttt cca ggg ctc ttg aga      435
 Ser Arg Arg Ile Arg Arg Arg Arg His Thr Phe Pro Gly Leu Leu Arg
  45                  50                  55                  60

 gac cat acc ctg gga gtc tcg cgg gat ctc act ttt ctc ggc ggc gca      483
 Asp His Thr Leu Gly Val Ser Arg Asp Leu Thr Phe Leu Gly Gly Ala
                  65                  70                  75

 ggg aat gag aca gat cgc ggg aat tcc acc cgc gcc ggg aga tgg tct      531
 Gly Asn Glu Thr Asp Arg Gly Asn Ser Thr Arg Ala Gly Arg Trp Ser
              80                  85                  90

 ggt gac ttc gcg gct cct ccc acg tct ctc tgg gca gtc cgc ctt gcg      579
 Gly Asp Phe Ala Ala Pro Pro Thr Ser Leu Trp Ala Val Arg Leu Ala
          95                 100                 105

 cat gcg cag gcg gcg gtg gca agg cta cgg ttc gcg cca gcg gcc ggc      627
 His Ala Gln Ala Ala Val Ala Arg Leu Arg Phe Ala Pro Ala Ala Gly
     110                 115                 120

 gct atg ggg ctg agc cgc gtg cgg gcg gtt ttc ttt gac ttg gac aac      675
 Ala Met Gly Leu Ser Arg Val Arg Ala Val Phe Phe Asp Leu Asp Asn
 125                 130                 135                 140

 act ctc atc gac acg gcc ggg gcg agc agg aga ggc atg ttg gag gta      723
 Thr Leu Ile Asp Thr Ala Gly Ala Ser Arg Arg Gly Met Leu Glu Val
                 145                 150                 155

 ata aaa ctc tta caa tca aaa tac cat tat aaa gaa gag gct gaa atc      771
 Ile Lys Leu Leu Gln Ser Lys Tyr His Tyr Lys Glu Glu Ala Glu Ile
             160                 165                 170

 atc tgt gat aaa gtt caa gtt aaa ctc agc aag gaa tgt ttt cat cct      819
 Ile Cys Asp Lys Val Gln Val Lys Leu Ser Lys Glu Cys Phe His Pro
         175                 180                 185

 tac aat aca tgc att act gat tta agg act tca cat tgg gaa gaa gca      867
 Tyr Asn Thr Cys Ile Thr Asp Leu Arg Thr Ser His Trp Glu Glu Ala
     190                 195                 200

 atc cag gaa aca aaa ggt ggt gca gcc aat aga aaa ttg gct gaa gaa      915
 Ile Gln Glu Thr Lys Gly Gly Ala Ala Asn Arg Lys Leu Ala Glu Glu
 205                 210                 215                 220

 tgt tat ttc ctt tgg aaa tct aca cgt tta cag cat atg aca cta gca      963
 Cys Tyr Phe Leu Trp Lys Ser Thr Arg Leu Gln His Met Thr Leu Ala
                 225                 230                 235

 gaa gac gtc aaa gcc atg ctt act gaa ctt cga aag gag gtc cgc cta     1011
 Glu Asp Val Lys Ala Met Leu Thr Glu Leu Arg Lys Glu Val Arg Leu
             240                 245                 250

 ctt cta tta acg aat ggg gac aga cag acc cag agg gag aag att gag     1059
 Leu Leu Leu Thr Asn Gly Asp Arg Gln Thr Gln Arg Glu Lys Ile Glu
         255                 260                 265

 gct tgt gcc tgt cag tcc tat ttt gac gct gtt gtt gta ggt gga gag     1107
 Ala Cys Ala Cys Gln Ser Tyr Phe Asp Ala Val Val Val Gly Gly Glu
     270                 275                 280

 cag aga gag gag aaa cca gca ccg tcc ata ttt tat tac tgc tgc aat     1155
 Gln Arg Glu Glu Lys Pro Ala Pro Ser Ile Phe Tyr Tyr Cys Cys Asn
 285                 290                 295                 300

 ctt ctc gga gta caa cct ggg gac tgt gtg atg gtc ggt gac aca tta     1203
 Leu Leu Gly Val Gln Pro Gly Asp Cys Val Met Val Gly Asp Thr Leu
                 305                 310                 315

 gaa acc gac atc caa gga ggc ctc aat gca gga ttg aaa gca aca gtc     1251
 Glu Thr Asp Ile Gln Gly Gly Leu Asn Ala Gly Leu Lys Ala Thr Val
             320                 325                 330

 tgg atc aat aaa aat gga ata gtg cca ctg aag tcc tcc cca gtt ccg     1299
 Trp Ile Asn Lys Asn Gly Ile Val Pro Leu Lys Ser Ser Pro Val Pro
         335                 340                 345

 cat tac atg gtt tct tct gtg cta gag tta cct gct ctc tta caa agt     1347
 His Tyr Met Val Ser Ser Val Leu Glu Leu Pro Ala Leu Leu Gln Ser
     350                 355                 360

 ata gac tgc aaa gtc aga cct cag cat ctg ggg atg cca gtg ccc gca     1395
 Ile Asp Cys Lys Val Arg Pro Gln His Leu Gly Met Pro Val Pro Ala
 365                 370                 375                 380

 tct ttg gag gag tct gct gtg tac ctc att att tct cag cct tcc cct     1443
 Ser Leu Glu Glu Ser Ala Val Tyr Leu Ile Ile Ser Gln Pro Ser Pro
                 385                 390                 395

 ctg ctg gtc agg act cgc ttt ctt tag                                 1470
 Leu Leu Val Arg Thr Arg Phe Leu 
             400





      <210> 98
      <211> 2015
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (472)..(1548)

      <400> 98
 atgtggcagg acaacagggt aatagaggca agagggtcag caggaaaacc tgtgaacaaa     60

 tgtctctgca tcataaacaa ggtgtttagg aagcccaata acatcactca gggactccca    120

 cgtagcagtc cggggccact cactgggcaa acacgcgtat cgcagatcaa cgtggccgct    180

 acaagaggac cccggaagtc tcggccctac attaggcgca cacacggaaa tgcttctttc    240

 cgagccctca ttggctctga cggcattcat tcaacgcaga gctttctgag taatgtagtt    300

 gaccagctta ccccacgtgg tcccatggcg gcggccgcgc taaggttccc cgttcagggc    360

 acagtgactt ttgaagacgt ggctgtgaaa tttacccagg aggaatggaa tctccttagt    420

 gaggctcaga gatgcctgta ccgtgatgtg acgctggaga acctggcact t atg tcc     477
                                                          Met Ser
                                                            1

 tcc ctg ggt tgt tgg tgt gga gtg gaa gat gag gcg gca cct tct aag      525
 Ser Leu Gly Cys Trp Cys Gly Val Glu Asp Glu Ala Ala Pro Ser Lys
           5                  10                  15

 cag agt att tat ata caa aga gag act cag gtc agg act cct atg gca      573
 Gln Ser Ile Tyr Ile Gln Arg Glu Thr Gln Val Arg Thr Pro Met Ala
      20                  25                  30

 ggt gtg tct ccc aag aag gcc cac ccc tgt gag atg tgt ggc ccg atc      621
 Gly Val Ser Pro Lys Lys Ala His Pro Cys Glu Met Cys Gly Pro Ile
  35                  40                  45                  50

 ttg gga gac att ttg cat gtg gca gat cat cag gga aca cat cac aag      669
 Leu Gly Asp Ile Leu His Val Ala Asp His Gln Gly Thr His His Lys
                  55                  60                  65

 cag aaa ctg cac agg tgt gag gcc tgg ggg aat aaa ttg tat gac agt      717
 Gln Lys Leu His Arg Cys Glu Ala Trp Gly Asn Lys Leu Tyr Asp Ser
              70                  75                  80

 gga aac ttt cat cag cac cag aat gag cac att gga gag aaa ccc tac      765
 Gly Asn Phe His Gln His Gln Asn Glu His Ile Gly Glu Lys Pro Tyr
          85                  90                  95

 aga ggg agt gtt gag gag gcg ttg ttt gcg aag agg tgt aag ttg cat      813
 Arg Gly Ser Val Glu Glu Ala Leu Phe Ala Lys Arg Cys Lys Leu His
     100                 105                 110

 gtg tca ggg gag tca tct gtc ttc agt gag agt ggg aaa gac ttt ttg      861
 Val Ser Gly Glu Ser Ser Val Phe Ser Glu Ser Gly Lys Asp Phe Leu
 115                 120                 125                 130

 ctc agg tca gga tta ctc cag caa gag gcc act cac act ggg aag tca      909
 Leu Arg Ser Gly Leu Leu Gln Gln Glu Ala Thr His Thr Gly Lys Ser
                 135                 140                 145

 aac agc aaa act gag tgt gtg tct ctg ttt cat ggg gga aaa agc cat      957
 Asn Ser Lys Thr Glu Cys Val Ser Leu Phe His Gly Gly Lys Ser His
             150                 155                 160

 tac agc tgt gga gga tgc atg aaa cat ttt agc acc aaa gat ata ctc     1005
 Tyr Ser Cys Gly Gly Cys Met Lys His Phe Ser Thr Lys Asp Ile Leu
         165                 170                 175

 agt cag cac gag aga ctg ctc cct aca gaa gaa cct tct gtg tgg tgt     1053
 Ser Gln His Glu Arg Leu Leu Pro Thr Glu Glu Pro Ser Val Trp Cys
     180                 185                 190

 gaa tgt ggg aaa tcc tct agc aaa tat gac agc ttc agt aat cat caa     1101
 Glu Cys Gly Lys Ser Ser Ser Lys Tyr Asp Ser Phe Ser Asn His Gln
 195                 200                 205                 210

 gga gtt cac act aga gaa aaa cct tat acg tgt ggg ata tgt ggg aaa     1149
 Gly Val His Thr Arg Glu Lys Pro Tyr Thr Cys Gly Ile Cys Gly Lys
                 215                 220                 225

 tta ttt aac agt aag tcc cac ctc ctt gta cac cag aga att cac act     1197
 Leu Phe Asn Ser Lys Ser His Leu Leu Val His Gln Arg Ile His Thr
             230                 235                 240

 gga gag aag cca tat gag tgt gag gtt tgt cag aaa ttt ttt agg cac     1245
 Gly Glu Lys Pro Tyr Glu Cys Glu Val Cys Gln Lys Phe Phe Arg His
         245                 250                 255

 aag tac cac ctc att gca cac cag aga gtt cac act gga gaa agg cca     1293
 Lys Tyr His Leu Ile Ala His Gln Arg Val His Thr Gly Glu Arg Pro
     260                 265                 270

 tat gaa tgc agt gat tgt ggg aag tca ttt acc cac agc tct aca ttc     1341
 Tyr Glu Cys Ser Asp Cys Gly Lys Ser Phe Thr His Ser Ser Thr Phe
 275                 280                 285                 290

 cgt gtt cat aag aga gtt cac act ggt cag aag cct tat gag tgc agt     1389
 Arg Val His Lys Arg Val His Thr Gly Gln Lys Pro Tyr Glu Cys Ser
                 295                 300                 305

 gaa tgt ggg aaa tct ttt gcc gaa agc tcc agt ctc act aaa cac agg     1437
 Glu Cys Gly Lys Ser Phe Ala Glu Ser Ser Ser Leu Thr Lys His Arg
             310                 315                 320

 aga gtt cac act gga gaa aag cct tac ggg tgc agt gaa tgt gaa aaa     1485
 Arg Val His Thr Gly Glu Lys Pro Tyr Gly Cys Ser Glu Cys Glu Lys
         325                 330                 335

 aaa ttt agg caa atc tct tca ctt cgt cat cat cag aga gtt cac aaa     1533
 Lys Phe Arg Gln Ile Ser Ser Leu Arg His His Gln Arg Val His Lys
     340                 345                 350

 aga aag ggc tta tga gtgcagtgag tccagtctca ttaaatattg gagaatacac     1588
 Arg Lys Gly Leu 
 355

 acctgagtaa gatcctgtga ttgcagcaaa tgtggaaaat gtttacccaa aggtctgctc   1648

 tccttggata ttggagagtt cacactagag aagagtcctt acaagtaaaa taaatttggg   1708

 cagttttgta gccacacctc tgtattcctt caggattata gttaacactg aatgaaggcc   1768

 ttactagtgt gacaaataca ggatatttat ccagaagtct ggctgcataa ctcacaggag   1828

 agctgtcatg tgggaggatt gctacatggg aggatttgct tgagcctggg aggcagaggt   1888

 tgcagtgagc cgagattgca acactgcagt ccagtctgga ccacagagtg agaccctgtt   1948

 tcaaaaataa aatatataaa tgacatccaa taaagtatgc atatttgagc tgtaaaaaaa   2008

 aaaaaaa                                                             2015




      <210> 99
      <211> 949
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (115)..(687)

      <400> 99
 taagcttgcg gccgccggct gaatgaagcc tgggacgcgg gagccgcgcc gcgcgcagtg     60

 tctgcagtgc cggaggtctg ggaggctccg ggcgaagcct ccctgctgca ggtt  atg     117
                                                              Met
                                                                1

 atg atg tca gac aat gct aaa ggc aga gca gct cat tca tgg aag aaa      165
 Met Met Ser Asp Asn Ala Lys Gly Arg Ala Ala His Ser Trp Lys Lys
               5                  10                  15

 aga ggg agt att tct tct cta agt aat cat gaa ttt tgg cga aag gaa      213
 Arg Gly Ser Ile Ser Ser Leu Ser Asn His Glu Phe Trp Arg Lys Glu
          20                  25                  30

 att cat ggg cgc atc aaa gat tct atg agt act gtg tct tat atg gaa      261
 Ile His Gly Arg Ile Lys Asp Ser Met Ser Thr Val Ser Tyr Met Glu
      35                  40                  45

 gaa ccc agt cag cgt gat gat atc tct cgc ctt aca gtt cag atg gaa      309
 Glu Pro Ser Gln Arg Asp Asp Ile Ser Arg Leu Thr Val Gln Met Glu
  50                  55                  60                  65

 aac acc tat cag ttg ggt cct ccc aaa cat ttt cct gtg gtc acc gtc      357
 Asn Thr Tyr Gln Leu Gly Pro Pro Lys His Phe Pro Val Val Thr Val
                  70                  75                  80

 aat cat att ttg aaa gat gta gta acc agc tat cta caa gta gaa gaa      405
 Asn His Ile Leu Lys Asp Val Val Thr Ser Tyr Leu Gln Val Glu Glu
              85                  90                  95

 tat gaa cca gag ctc tgt aga cag atg act aaa acc att tct gag gtt      453
 Tyr Glu Pro Glu Leu Cys Arg Gln Met Thr Lys Thr Ile Ser Glu Val
         100                 105                 110

 att aaa gcc cag gtc aag gac ttg atg att cca cgg tat aaa cta att      501
 Ile Lys Ala Gln Val Lys Asp Leu Met Ile Pro Arg Tyr Lys Leu Ile
     115                 120                 125

 gtg att gtt cac att gga caa ctg aac agg cag agc ata ctt att gga      549
 Val Ile Val His Ile Gly Gln Leu Asn Arg Gln Ser Ile Leu Ile Gly
 130                 135                 140                 145

 agc aga tgc ctc tgg gat cct aaa agt gat acc ttt tca tct tat gtt      597
 Ser Arg Cys Leu Trp Asp Pro Lys Ser Asp Thr Phe Ser Ser Tyr Val
                 150                 155                 160

 ttc aga aat tct tct ctc ttc gct ctt gca aat gtc tat gca gtt tac      645
 Phe Arg Asn Ser Ser Leu Phe Ala Leu Ala Asn Val Tyr Ala Val Tyr
             165                 170                 175

 ctt gag gtg att gaa aat aag aaa tct agc tct tac ttt tga aaattct      694
 Leu Glu Val Ile Glu Asn Lys Lys Ser Ser Ser Tyr Phe 
         180                 185                 190

 gaggcaggct gtatgtctgt acacaaaagt tttactggca aaaactttga gaaagaaaca    754

 acactgatat tttcaagcaa ctggaagctt ttgaattctt ttcaaattcc aataaagaat    814

 tacggggagg ggagggtagc caacagaaag aaatcctgtt taaccaaaag caggaaactt    874

 gaaacttggg tttttgccgg gatgcctttc caaagaaaaa agaattccca aataaaaaaa    934

 tcgcttctgg gaccc                                                     949




      <210> 100
      <211> 3018
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (144)..(2756)

      <220>
      <221> misc_feature
      <222> (1)...(3018)
      <223> n = a,t,c or g

      <400> 100
 ccggtccgga attcccgggc gaggcggcag ctgcgcggcg gcaccggggc ggctgcggcg     60

 cgctcggagc cccgagggca cgcggcccgg gcagctcggt gtgcgccccc gcgagagccg    120

 gggccccagg cccgccggac acc    atg aac cac ctg aac gtg ctg gcc aaa     170
                              Met Asn His Leu Asn Val Leu Ala Lys
                                1               5

 gcg ctc tat gac aat gtg gcc gag tcc ccg gat gag ctc tcc ttc cgc      218
 Ala Leu Tyr Asp Asn Val Ala Glu Ser Pro Asp Glu Leu Ser Phe Arg
  10                  15                  20                  25

 aag ggt gac atc atg acg gtg ctg gag cag gac acg cag ggc ctg gac      266
 Lys Gly Asp Ile Met Thr Val Leu Glu Gln Asp Thr Gln Gly Leu Asp
                  30                  35                  40

 ggc tgg tgg ctc tgc tcg ctg cat ggg cgc cag ggc atc gtg cct ggg      314
 Gly Trp Trp Leu Cys Ser Leu His Gly Arg Gln Gly Ile Val Pro Gly
              45                  50                  55

 aac cgc ctc aag atc ttg gtg ggc atg tat gat aag aag cca gca ggg      362
 Asn Arg Leu Lys Ile Leu Val Gly Met Tyr Asp Lys Lys Pro Ala Gly
          60                  65                  70

 cct ggc tcc ggc cct ccc gcc acc ccg gcc cag cct cag cct ggc ctc      410
 Pro Gly Ser Gly Pro Pro Ala Thr Pro Ala Gln Pro Gln Pro Gly Leu
      75                  80                  85

 cat gcc cca gcg cct ccg gcc tcc cag tac acg ccc atg ctc ccc aac      458
 His Ala Pro Ala Pro Pro Ala Ser Gln Tyr Thr Pro Met Leu Pro Asn
  90                  95                 100                 105

 acc tac cag ccc cag cca gac agc gtc tac ctg gtg ccc act ccc agc      506
 Thr Tyr Gln Pro Gln Pro Asp Ser Val Tyr Leu Val Pro Thr Pro Ser
                 110                 115                 120

 aag gct cag caa ggc ctc tac caa gtc ccg ggt ccc agc cct cag ttc      554
 Lys Ala Gln Gln Gly Leu Tyr Gln Val Pro Gly Pro Ser Pro Gln Phe
             125                 130                 135

 cag tct ccc cca gcc aag cag aca tcc acc ttc tcg aag cag aca ccc      602
 Gln Ser Pro Pro Ala Lys Gln Thr Ser Thr Phe Ser Lys Gln Thr Pro
         140                 145                 150

 cat cac ccg ttt ccc agc ccg gcc aca gac ctg tac cag gtg ccc cca      650
 His His Pro Phe Pro Ser Pro Ala Thr Asp Leu Tyr Gln Val Pro Pro
     155                 160                 165

 ggg cct gga ggc cct gcc cag gat att tac cag gtg cca cct tct gcc      698
 Gly Pro Gly Gly Pro Ala Gln Asp Ile Tyr Gln Val Pro Pro Ser Ala
 170                 175                 180                 185

 ggg atg ggg cat gac atc tac cag gtc ccc ccg tcc atg gac aca cgc      746
 Gly Met Gly His Asp Ile Tyr Gln Val Pro Pro Ser Met Asp Thr Arg
                 190                 195                 200

 agc tgg gag ggc acg aag ccc ccg gca aag gtg gtg gtg ccc acc cgc      794
 Ser Trp Glu Gly Thr Lys Pro Pro Ala Lys Val Val Val Pro Thr Arg
             205                 210                 215

 gtg ggg cag ggc tat gta tac gag gcc gcc cag ccg gag cag gac gag      842
 Val Gly Gln Gly Tyr Val Tyr Glu Ala Ala Gln Pro Glu Gln Asp Glu
         220                 225                 230

 tac gac acc ccg cga cac ctg ctg gcc ccg ggg cca cag gac atc tat      890
 Tyr Asp Thr Pro Arg His Leu Leu Ala Pro Gly Pro Gln Asp Ile Tyr
     235                 240                 245

 gat gtg ccc ccg gtt cgg ggg ctg ctt ccc agc cag tat ggc cag gag      938
 Asp Val Pro Pro Val Arg Gly Leu Leu Pro Ser Gln Tyr Gly Gln Glu
 250                 255                 260                 265

 gtg tat gac aca ccc ccc atg gct gtc aag ggt ccc aat ggc cga gac      986
 Val Tyr Asp Thr Pro Pro Met Ala Val Lys Gly Pro Asn Gly Arg Asp
                 270                 275                 280

 ccg ttg ctg gag gtg tat gac gtg ccc ccc agt gtg gag aag ggc ctg     1034
 Pro Leu Leu Glu Val Tyr Asp Val Pro Pro Ser Val Glu Lys Gly Leu
             285                 290                 295

 cca ccg tcc aac cac cac gca gtc tac gac gtt cct cca tcg gtg agc     1082
 Pro Pro Ser Asn His His Ala Val Tyr Asp Val Pro Pro Ser Val Ser
         300                 305                 310

 aag gat gtg ccc gat ggc cca ctg ctg cgt gag gag acc tac gat gtg     1130
 Lys Asp Val Pro Asp Gly Pro Leu Leu Arg Glu Glu Thr Tyr Asp Val
     315                 320                 325

 ccc ccc gcc ttc gcc aag gcc aag ccc ttt gac ccg gcc cgc acc ccc     1178
 Pro Pro Ala Phe Ala Lys Ala Lys Pro Phe Asp Pro Ala Arg Thr Pro
 330                 335                 340                 345

 ctg gta ctg ggt gcg ccc cct cca gac tcc ccg ccg gcc gag gac gtg     1226
 Leu Val Leu Gly Ala Pro Pro Pro Asp Ser Pro Pro Ala Glu Asp Val
                 350                 355                 360

 tat tac gtg ccg ccc ccg gct cct gac ctc tac gac gtg ccc cct ggc     1274
 Tyr Tyr Val Pro Pro Pro Ala Pro Asp Leu Tyr Asp Val Pro Pro Gly
             365                 370                 375

 ttg cgg cgg cct ggc ccg ggc acc ctg tac gat gtg ccc cgt gaa cgg     1322
 Leu Arg Arg Pro Gly Pro Gly Thr Leu Tyr Asp Val Pro Arg Glu Arg
         380                 385                 390

 gtg ctt cct cct gag gtg gct gat ggt ggc gtg gtc gac agt ggt gtg     1370
 Val Leu Pro Pro Glu Val Ala Asp Gly Gly Val Val Asp Ser Gly Val
     395                 400                 405

 tat gcg gtg cct ccc cca gct gaa cgt gaa gcc ccg gca gag ggc aag     1418
 Tyr Ala Val Pro Pro Pro Ala Glu Arg Glu Ala Pro Ala Glu Gly Lys
 410                 415                 420                 425

 cgc ctg tcg gcc tcc agc acc ggc agc aca cgc agc agc cag tct gcg     1466
 Arg Leu Ser Ala Ser Ser Thr Gly Ser Thr Arg Ser Ser Gln Ser Ala
                 430                 435                 440

 tcc tcc ttg gag gtg gca ggg ccg ggc cgg gaa ccc ctg gag ctg gaa     1514
 Ser Ser Leu Glu Val Ala Gly Pro Gly Arg Glu Pro Leu Glu Leu Glu
             445                 450                 455

 gtt gct gtg gag gcc ctg gca cgg ctg cag cag ggt gtg agc gcc acc     1562
 Val Ala Val Glu Ala Leu Ala Arg Leu Gln Gln Gly Val Ser Ala Thr
         460                 465                 470

 gtt gcc cac ctt ctg gac ctg gca ggc agc gcc ggt gcg act ggg agc     1610
 Val Ala His Leu Leu Asp Leu Ala Gly Ser Ala Gly Ala Thr Gly Ser
     475                 480                 485

 tgg cgt agc ccc tct gag cca cag gag ccg ctg gtg cag gac ctg cag     1658
 Trp Arg Ser Pro Ser Glu Pro Gln Glu Pro Leu Val Gln Asp Leu Gln
 490                 495                 500                 505

 gct gct gtg gcc gcc gtc cag agt gcc gtc cac gag ctg ttg gag ttt     1706
 Ala Ala Val Ala Ala Val Gln Ser Ala Val His Glu Leu Leu Glu Phe
                 510                 515                 520

 gcc cgc agc gcg gtg ggc aat gct gcc cac aca tct gac cgt gcc ctg     1754
 Ala Arg Ser Ala Val Gly Asn Ala Ala His Thr Ser Asp Arg Ala Leu
             525                 530                 535

 cat gcc aag ctt agc cgg cag ctg cag aag atg gag gac gtg cac cag     1802
 His Ala Lys Leu Ser Arg Gln Leu Gln Lys Met Glu Asp Val His Gln
         540                 545                 550

 acg ctg gtg gca cat ggt cag gcc ctc gac gct ggc cgg gga ggc tct     1850
 Thr Leu Val Ala His Gly Gln Ala Leu Asp Ala Gly Arg Gly Gly Ser
     555                 560                 565

 gga gcc acc ctt gag gac ctg gac cgg ctg gtg gcc tgc tcg cgg gct     1898
 Gly Ala Thr Leu Glu Asp Leu Asp Arg Leu Val Ala Cys Ser Arg Ala
 570                 575                 580                 585

 gtg ccc gag gac gcc aag cag ctg gcc tcc ttc ctg cac ggc aat gcc     1946
 Val Pro Glu Asp Ala Lys Gln Leu Ala Ser Phe Leu His Gly Asn Ala
                 590                 595                 600

 tca ctg ctc ttc aga cgg acc aag gcc act gcc ccg ggg cct gag ggg     1994
 Ser Leu Leu Phe Arg Arg Thr Lys Ala Thr Ala Pro Gly Pro Glu Gly
             605                 610                 615

 ggt ggc acc ctg cac ccc aac ccc act gac aag acc agc agc atc cag     2042
 Gly Gly Thr Leu His Pro Asn Pro Thr Asp Lys Thr Ser Ser Ile Gln
         620                 625                 630

 tca cga ccc ctg ccc tca ccc cct aag ttc acc tcc cag gac tcg cca     2090
 Ser Arg Pro Leu Pro Ser Pro Pro Lys Phe Thr Ser Gln Asp Ser Pro
     635                 640                 645

 gat ggg cag tac gag aac agc gag ggg ggc tgg atg gag gac tat gac     2138
 Asp Gly Gln Tyr Glu Asn Ser Glu Gly Gly Trp Met Glu Asp Tyr Asp
 650                 655                 660                 665

 tac gtc cac cta cag ggg aag gag gag ttt gag aag acc cag aag gag     2186
 Tyr Val His Leu Gln Gly Lys Glu Glu Phe Glu Lys Thr Gln Lys Glu
                 670                 675                 680

 ctg ctg gaa aag ggc agc atc acg cgg cag ggc aag agc cag ctg gag     2234
 Leu Leu Glu Lys Gly Ser Ile Thr Arg Gln Gly Lys Ser Gln Leu Glu
             685                 690                 695

 ttg cag cag ctg aag cag ttt gaa cga ctg gaa cag gag gtg tca cgg     2282
 Leu Gln Gln Leu Lys Gln Phe Glu Arg Leu Glu Gln Glu Val Ser Arg
         700                 705                 710

 ccc ata gac cac gac ctg gcc aac tgg acg cca gcc caa ccc ctg gcc     2330
 Pro Ile Asp His Asp Leu Ala Asn Trp Thr Pro Ala Gln Pro Leu Ala
     715                 720                 725

 ccg ggg cga aca ggc ggc ctg ggg ccc tcg gac cgg cag ctg ctg ctc     2378
 Pro Gly Arg Thr Gly Gly Leu Gly Pro Ser Asp Arg Gln Leu Leu Leu
 730                 735                 740                 745

 ttc tac ctg gag cag tgt gag gcc aac ctg acc aca ctg acc aac gcc     2426
 Phe Tyr Leu Glu Gln Cys Glu Ala Asn Leu Thr Thr Leu Thr Asn Ala
                 750                 755                 760

 gtg gac gcc ttc ttt acc gcc gtg gcc acc aac cag ccg ccc aag atc     2474
 Val Asp Ala Phe Phe Thr Ala Val Ala Thr Asn Gln Pro Pro Lys Ile
             765                 770                 775

 ttt gtg gcg cac agc aag ttc gtc atc ctc agc gcc cac aag ctg gtg     2522
 Phe Val Ala His Ser Lys Phe Val Ile Leu Ser Ala His Lys Leu Val
         780                 785                 790

 ttc atc ggg gac aca ctg tca cgg cag gcc aag gct gct gac gtg cgc     2570
 Phe Ile Gly Asp Thr Leu Ser Arg Gln Ala Lys Ala Ala Asp Val Arg
     795                 800                 805

 acg cag gtg acc cac tac agc aac ctg ctg tgc gac ctc ctg cgc ggc     2618
 Thr Gln Val Thr His Tyr Ser Asn Leu Leu Cys Asp Leu Leu Arg Gly
 810                 815                 820                 825

 atc gtg gcc acc acc aag gcc gct gcc ttg cag tac cca tcg cct tcc     2666
 Ile Val Ala Thr Thr Lys Ala Ala Ala Leu Gln Tyr Pro Ser Pro Ser
                 830                 835                 840

 gcg gcc cag gac atg gtg gag agg gtc aag gag ctg ggc cac agc acc     2714
 Ala Ala Gln Asp Met Val Glu Arg Val Lys Glu Leu Gly His Ser Thr
             845                 850                 855

 cag cag ttc cgc cgc gtc cta ggc cag ctg gca gcc gcc tga gggtggt     2763
 Gln Gln Phe Arg Arg Val Leu Gly Gln Leu Ala Ala Ala 
         860                 865                 870

 gaccccagga gggaggcagg ggaggggtgc ggcggtccca gctccctggc tcccatgtca   2823

 agagtcgctg tgccacaggc ttagggacag gaccccagct ctgcgtcggt cctggtgccc   2883

 tggatgccag gaatctgtat atatttatgg ccgggcaggg tgtggggcca tgctcctcag   2943

 gagccgaagc ccaggggccg gccagtggct tccccagcat gncacacggg cccgggttgg   3003

 gtcacagacg gggct                                                    3018




      <210> 101
      <211> 1364
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (98)..(1273)

      <400> 101
 aaggatcctt aattaaatta atcccccccc cccaggctta cgaggcctgt gtcgggtaga     60

 aagggtcctt cctggaccgg gaccctctgc cacgacc atg gac cgt agg aaa aag     115
                                          Met Asp Arg Arg Lys Lys
                                            1               5

 cct ttg gac gtc acg gcc tcc tcg ttg gta gat ctt aag gct gaa ctc      163
 Pro Leu Asp Val Thr Ala Ser Ser Leu Val Asp Leu Lys Ala Glu Leu
              10                  15                  20

 ttc cga aag caa gaa gaa ttc aaa caa gaa aaa ctt cta aaa gat tct      211
 Phe Arg Lys Gln Glu Glu Phe Lys Gln Glu Lys Leu Leu Lys Asp Ser
          25                  30                  35

 gga gtt ttt gga aaa cca aaa aca act aac aag aaa cca agt atc tgg      259
 Gly Val Phe Gly Lys Pro Lys Thr Thr Asn Lys Lys Pro Ser Ile Trp
      40                  45                  50

 agc aaa cag aat gta ggc gtt tca aat cga gct gag aag gat gct gaa      307
 Ser Lys Gln Asn Val Gly Val Ser Asn Arg Ala Glu Lys Asp Ala Glu
  55                  60                  65                  70

 cag aag att gaa gaa cag aag act tta gac aaa gca agg gaa aaa ttg      355
 Gln Lys Ile Glu Glu Gln Lys Thr Leu Asp Lys Ala Arg Glu Lys Leu
                  75                  80                  85

 gaa gaa aaa gcc aaa tta tat gaa aaa atg act aaa gga gac ttt ata      403
 Glu Glu Lys Ala Lys Leu Tyr Glu Lys Met Thr Lys Gly Asp Phe Ile
              90                  95                 100

 gat gaa gaa gta gag gat atg tac ctt gtg gat ttc aca cag aag atc      451
 Asp Glu Glu Val Glu Asp Met Tyr Leu Val Asp Phe Thr Gln Lys Ile
         105                 110                 115

 ata gac aag cgc aaa gaa atg gag gca tct ggt gcc cat aga gat tct      499
 Ile Asp Lys Arg Lys Glu Met Glu Ala Ser Gly Ala His Arg Asp Ser
     120                 125                 130

 caa aag gca gga gaa agg gac gac gat gag gaa aac ctt cct gag gga      547
 Gln Lys Ala Gly Glu Arg Asp Asp Asp Glu Glu Asn Leu Pro Glu Gly
 135                 140                 145                 150

 gag atc cct cct ccc caa gac ccc agt gaa gaa tgg gtg gat tac gtg      595
 Glu Ile Pro Pro Pro Gln Asp Pro Ser Glu Glu Trp Val Asp Tyr Val
                 155                 160                 165

 gac tct ttg ggg cgt tcc cgg cgc tgt atg aga aag gat ttg cca gat      643
 Asp Ser Leu Gly Arg Ser Arg Arg Cys Met Arg Lys Asp Leu Pro Asp
             170                 175                 180

 ctg ctg gag atg gat aaa aat ctt cag ggg aga ctt ttt att agt cct      691
 Leu Leu Glu Met Asp Lys Asn Leu Gln Gly Arg Leu Phe Ile Ser Pro
         185                 190                 195

 gct aat gaa aaa acc cta tta tct gaa gat atg aga aaa gaa ctt cag      739
 Ala Asn Glu Lys Thr Leu Leu Ser Glu Asp Met Arg Lys Glu Leu Gln
     200                 205                 210

 cgc cag caa tgg gag gaa gaa gaa aga gag gcc ctg aag agg ccc atg      787
 Arg Gln Gln Trp Glu Glu Glu Glu Arg Glu Ala Leu Lys Arg Pro Met
 215                 220                 225                 230

 ggg ccc gta cat tat gaa gac att cgg gaa aat gat gga gat gtt att      835
 Gly Pro Val His Tyr Glu Asp Ile Arg Glu Asn Asp Gly Asp Val Ile
                 235                 240                 245

 ggg cct ttg cca ccg gag cca gag gct gtg cca acc cca cgt cct gct      883
 Gly Pro Leu Pro Pro Glu Pro Glu Ala Val Pro Thr Pro Arg Pro Ala
             250                 255                 260

 gcc cag agt agc aaa gta gaa gtc att gtc cag gag agg aag gac acc      931
 Ala Gln Ser Ser Lys Val Glu Val Ile Val Gln Glu Arg Lys Asp Thr
         265                 270                 275

 aag cct gga gtg cca cac atc cgg gag tgg gac cgc gga aaa gaa ttt      979
 Lys Pro Gly Val Pro His Ile Arg Glu Trp Asp Arg Gly Lys Glu Phe
     280                 285                 290

 tcc ttt gga tac tgg tcg aag agg cag tca gat ctc cgg gct gag aga     1027
 Ser Phe Gly Tyr Trp Ser Lys Arg Gln Ser Asp Leu Arg Ala Glu Arg
 295                 300                 305                 310

 gat cct gag ttt gcc cca ccg tca gat tac ttt gtg ggt cag aag aga     1075
 Asp Pro Glu Phe Ala Pro Pro Ser Asp Tyr Phe Val Gly Gln Lys Arg
                 315                 320                 325

 act ggt ttt tcc agc agc cag gca tgg agc aga cct ggg cca gca cag     1123
 Thr Gly Phe Ser Ser Ser Gln Ala Trp Ser Arg Pro Gly Pro Ala Gln
             330                 335                 340

 agt gac cca ggg cag tgc cct gac cag agc cac gga cct agc cct gaa     1171
 Ser Asp Pro Gly Gln Cys Pro Asp Gln Ser His Gly Pro Ser Pro Glu
         345                 350                 355

 cat acg tca ccc act cct gcc ccc gac aac cca cca caa gcc ccc aca     1219
 His Thr Ser Pro Thr Pro Ala Pro Asp Asn Pro Pro Gln Ala Pro Thr
     360                 365                 370

 gtt act ttc aaa act ctg gat gac atg att tcc tat tac aaa caa gtg     1267
 Val Thr Phe Lys Thr Leu Asp Asp Met Ile Ser Tyr Tyr Lys Gln Val
 375                 380                 385                 390

 aca tga tctttcaaaa aaaaaaaaaa agggcggccg ctctagagta tccctcaagg      1323
 Thr 


 ggcccaagct tacgcgtacc cagctttctt gtacaaagtg g                       1364




      <210> 102
      <211> 1592
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (98)..(1501)

      <400> 102
 aaggatcctt aattaaatta atcccccccc cccaggctta cgaggcctgt gtcgggtaga     60

 aagggtcctt cctggaccgg gaccctctgc cacgacc atg gac cgt agg aaa aag     115
                                          Met Asp Arg Arg Lys Lys
                                            1               5

 cct ttg gac gtc acg gcc tcc tcg ttg gta gat ctt aag gct gaa ctc      163
 Pro Leu Asp Val Thr Ala Ser Ser Leu Val Asp Leu Lys Ala Glu Leu
              10                  15                  20

 ttc cga aag caa gaa gaa ttc aaa caa gaa aaa ctt cta aaa gat tct      211
 Phe Arg Lys Gln Glu Glu Phe Lys Gln Glu Lys Leu Leu Lys Asp Ser
          25                  30                  35

 gga gtt ttt gga aaa cca aaa aca act aac aag aaa cca agt atc tgg      259
 Gly Val Phe Gly Lys Pro Lys Thr Thr Asn Lys Lys Pro Ser Ile Trp
      40                  45                  50

 agc aaa cag aat gta ggc gtt tca aat cga gct gag aag gat gct gaa      307
 Ser Lys Gln Asn Val Gly Val Ser Asn Arg Ala Glu Lys Asp Ala Glu
  55                  60                  65                  70

 cag aag att gaa gaa cag aag act tta gac aaa gca agg gaa aaa ttg      355
 Gln Lys Ile Glu Glu Gln Lys Thr Leu Asp Lys Ala Arg Glu Lys Leu
                  75                  80                  85

 gaa gaa aaa gcc aaa tta tat gaa aaa atg act aaa gga gac ttt ata      403
 Glu Glu Lys Ala Lys Leu Tyr Glu Lys Met Thr Lys Gly Asp Phe Ile
              90                  95                 100

 gat gaa gaa gta gag gat atg tac ctt gtg gat ttc aca cag aag atc      451
 Asp Glu Glu Val Glu Asp Met Tyr Leu Val Asp Phe Thr Gln Lys Ile
         105                 110                 115

 ata gac aag cgc aaa gaa atg gag gca tct ggt gcc cat aga gat tct      499
 Ile Asp Lys Arg Lys Glu Met Glu Ala Ser Gly Ala His Arg Asp Ser
     120                 125                 130

 caa aag gca gga gaa agg gac gac gat gag gaa aac ctt cct gag gga      547
 Gln Lys Ala Gly Glu Arg Asp Asp Asp Glu Glu Asn Leu Pro Glu Gly
 135                 140                 145                 150

 gag atc cct cct ccc caa gac ccc agt gaa gaa tgg gtg gat tac gtg      595
 Glu Ile Pro Pro Pro Gln Asp Pro Ser Glu Glu Trp Val Asp Tyr Val
                 155                 160                 165

 gac tct ttg ggg cgt tcc cgg cgc tgt atg aga aag gat ttg cca gat      643
 Asp Ser Leu Gly Arg Ser Arg Arg Cys Met Arg Lys Asp Leu Pro Asp
             170                 175                 180

 ctg ctg gag atg gat aaa aat ctt cag ggg aga ctt ttt att agt cct      691
 Leu Leu Glu Met Asp Lys Asn Leu Gln Gly Arg Leu Phe Ile Ser Pro
         185                 190                 195

 gct aat gaa aaa acc cta tta tct gaa gat atg aga aaa gaa ctt cag      739
 Ala Asn Glu Lys Thr Leu Leu Ser Glu Asp Met Arg Lys Glu Leu Gln
     200                 205                 210

 cgc cag caa tgg gag gaa gaa gaa aga gag gcc ctg aag agg ccc atg      787
 Arg Gln Gln Trp Glu Glu Glu Glu Arg Glu Ala Leu Lys Arg Pro Met
 215                 220                 225                 230

 ggg ccc gta cat tat gaa gac att cgg gaa aat gag gcc cgg caa ctt      835
 Gly Pro Val His Tyr Glu Asp Ile Arg Glu Asn Glu Ala Arg Gln Leu
                 235                 240                 245

 ggt gtt ggg tat ttt gcc ttt gcc cga gac aaa gag ttg aga aac aag      883
 Gly Val Gly Tyr Phe Ala Phe Ala Arg Asp Lys Glu Leu Arg Asn Lys
             250                 255                 260

 cag atg aaa acc tta gag atg ctg cgt gaa cag aca aca gat cag aga      931
 Gln Met Lys Thr Leu Glu Met Leu Arg Glu Gln Thr Thr Asp Gln Arg
         265                 270                 275

 aca aaa cga gaa aac ata aag gaa aag cga aag gct atc tta gag gca      979
 Thr Lys Arg Glu Asn Ile Lys Glu Lys Arg Lys Ala Ile Leu Glu Ala
     280                 285                 290

 aga ctt gcc aaa ctt cga caa aaa agg atg aaa aaa tca aaa gaa ggt     1027
 Arg Leu Ala Lys Leu Arg Gln Lys Arg Met Lys Lys Ser Lys Glu Gly
 295                 300                 305                 310

 gga aca gaa gaa gaa aat aga gat gga gat gtt att ggg cct ttg cca     1075
 Gly Thr Glu Glu Glu Asn Arg Asp Gly Asp Val Ile Gly Pro Leu Pro
                 315                 320                 325

 ccg gag cca gag gct gtg cca acc cca cgt cct gct gcc cag agt agc     1123
 Pro Glu Pro Glu Ala Val Pro Thr Pro Arg Pro Ala Ala Gln Ser Ser
             330                 335                 340

 aaa gta gaa gtc att gtc cag gag agg aag gac acc aag cct gga gtg     1171
 Lys Val Glu Val Ile Val Gln Glu Arg Lys Asp Thr Lys Pro Gly Val
         345                 350                 355

 cca cac atc cgg gag tgg gac cgc gga aaa gaa ttt tcc ttt gga tac     1219
 Pro His Ile Arg Glu Trp Asp Arg Gly Lys Glu Phe Ser Phe Gly Tyr
     360                 365                 370

 tgg tcg aag agg cag tca gat ctc cgg gct gag aga gat cct gag ttt     1267
 Trp Ser Lys Arg Gln Ser Asp Leu Arg Ala Glu Arg Asp Pro Glu Phe
 375                 380                 385                 390

 gcc cca ccg tca gat tac ttt gtg ggt cag aag aga act ggt ttt tcc     1315
 Ala Pro Pro Ser Asp Tyr Phe Val Gly Gln Lys Arg Thr Gly Phe Ser
                 395                 400                 405

 agc agc cag gca tgg agc aga cct ggg cca gca cag agt gac cca ggg     1363
 Ser Ser Gln Ala Trp Ser Arg Pro Gly Pro Ala Gln Ser Asp Pro Gly
             410                 415                 420

 cag tgc cct gac cag agc cac gga cct agc cct gaa cat acg tca ccc     1411
 Gln Cys Pro Asp Gln Ser His Gly Pro Ser Pro Glu His Thr Ser Pro
         425                 430                 435

 act cct gcc ccc gac aac cca cca caa gcc ccc aca gtt act ttc aaa     1459
 Thr Pro Ala Pro Asp Asn Pro Pro Gln Ala Pro Thr Val Thr Phe Lys
     440                 445                 450

 act ctg gat gac atg att tcc tat tac aaa caa gtg aca tga tctttca     1508
 Thr Leu Asp Asp Met Ile Ser Tyr Tyr Lys Gln Val Thr 
 455                 460                 465

 aaaaaaaaaa aaaagggcgg ccgctctaga gtatccctca aggggcccaa gcttacgcgt   1568

 acccagcttt cttgtacaaa gtgg                                          1592




      <210> 103
      <211> 498
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (100)..(342)

      <400> 103
 tgaaagccat tttttttttc agctcacttc aagggtacct gaagcgaatt ggcaccaaag     60

 cagcagctgt attgccgcag ttctagcttc accttcacg   atg ttt ccc ttg gtc     114
                                              Met Phe Pro Leu Val
                                                1               5

 aaa agc gca cta aat cgt ctc caa gtt cga agc att cag caa aca atg      162
 Lys Ser Ala Leu Asn Arg Leu Gln Val Arg Ser Ile Gln Gln Thr Met
                  10                  15                  20

 gca agg cag agc cac cag aaa cgt aca cct gat ttt cat gac aaa tac      210
 Ala Arg Gln Ser His Gln Lys Arg Thr Pro Asp Phe His Asp Lys Tyr
              25                  30                  35

 ggt aat gct gta tta gct agt gga gcc act ttc tgt att gtt aca tgg      258
 Gly Asn Ala Val Leu Ala Ser Gly Ala Thr Phe Cys Ile Val Thr Trp
          40                  45                  50

 aca tat gta gca aca caa gtc gga ata gaa tgg aac ctg tcc cct gtt      306
 Thr Tyr Val Ala Thr Gln Val Gly Ile Glu Trp Asn Leu Ser Pro Val
      55                  60                  65

 ggc aga gtt acc cca aag gaa tgg agg aat cag taa tcat cccagctggt      356
 Gly Arg Val Thr Pro Lys Glu Trp Arg Asn Gln 
  70                  75                  80

 gtaataatga attgtttaaa aaacagctca taattgatgc caaattaaag cactgtgtac    416

 ccattaagat atggcattat tgaagaaata aagtacattt gaaaccttca aaagtcggac    476

 ggccgcgaat ttagtagtag ta                                             498




      <210> 104
      <211> 765
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (342)..(710)

      <400> 104
 gagcgcctga gaccttcgca gagcgtggaa ttcgtgtaaa agtcatttat gttatttaaa     60

 tgatgtactg tactgctgtt tacatggacg ttttgtgcgg gtgctttgaa gtgccttgca    120

 tcagggatta ggagcaatta aattattttt tcacgggact gtgtaaagca tgtaactagg    180

 tattgctttg gtatataact attgtagctt tacaagagat tgttttattt gaatggggaa    240

 aatacccttt aaattatgac ggacatccac tagagatggg tttgaggatt ttccaagcgt    300

 gtaataatga tgtttttcct aacatgacag atgagtagta a    atg ttg ata tat     353
                                                  Met Leu Ile Tyr
                                                    1

 cct atg gga ctt cta aaa gga act atg tct gga agg ctg tgg tcc aag      401
 Pro Met Gly Leu Leu Lys Gly Thr Met Ser Gly Arg Leu Trp Ser Lys
   5                  10                  15                  20

 gcc att ttt gct ggc tat aag cgg ggt ctc cgg aac caa agg gag cac      449
 Ala Ile Phe Ala Gly Tyr Lys Arg Gly Leu Arg Asn Gln Arg Glu His
                  25                  30                  35

 aca gct ctt ctt aaa att gaa ggt gtt tac gcc cga gat gaa aca gaa      497
 Thr Ala Leu Leu Lys Ile Glu Gly Val Tyr Ala Arg Asp Glu Thr Glu
              40                  45                  50

 ttc tat ttg ggc aag aga tgc gct tat gta tat aaa gca aag aac aac      545
 Phe Tyr Leu Gly Lys Arg Cys Ala Tyr Val Tyr Lys Ala Lys Asn Asn
          55                  60                  65

 aca gtc act cct ggc ggc aaa cca aac aaa acc aga gtc atc tgg gga      593
 Thr Val Thr Pro Gly Gly Lys Pro Asn Lys Thr Arg Val Ile Trp Gly
      70                  75                  80

 aaa gta act cgg gcc cat gga aac agt ggc atg gtt cgt gcc aaa ttc      641
 Lys Val Thr Arg Ala His Gly Asn Ser Gly Met Val Arg Ala Lys Phe
  85                  90                  95                 100

 cga agc aat ctt cct gct aag gcc att gga cac aga atc cga gtg atg      689
 Arg Ser Asn Leu Pro Ala Lys Ala Ile Gly His Arg Ile Arg Val Met
                 105                 110                 115

 ctg tac ccc tca agg att taa ac taacgaaaaa tcaataaatc aatgtggatt      742
 Leu Tyr Pro Ser Arg Ile 
             120

 tgtgctcttg taaaaaaaaa aaa                                            765




      <210> 105
      <211> 9405
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (496)..(9405)

      <400> 105
 atttttatgc ggcggaccgt gcggaagaac gtctaggagg gaggagtggg aggttggggg     60

 tgtcgctagg cgcccttagc tccctccctc tggaggagct gccgcggcca ctctgctgcc    120

 gccgctgccg acgccatttt gggttcgctt tgcgagggga aacgatccca gtgtcggttg    180

 cgggatccgc ctcctctcag tttgcccctt tagccctcca cctttccctt ctcctctctc    240

 gcatttccgc cagtcggctt acccgctggc cgcctcctga caagcgggag ggatccgcgg    300

 tggacccagg gaagcggagg agcctggcgg ccaccccctc ttcctcactt ccctgtactc    360

 tcatcgctct cggcctcggc ctcggcctcc gacacgagaa agatgctggt ttcgagtttt    420

 ggagatcctt gttttttatg gaacacagtt ctgtaaaatt ttcataagat tccttggcaa    480

 taacatacgc ttgtg atg gac cct aga aat act gct atg tta gga ttg ggt     531
                  Met Asp Pro Arg Asn Thr Ala Met Leu Gly Leu Gly
                    1               5                  10

 tct gat tcc gaa ggt ttt tca aga aag agt cct tct gcc atc agt act      579
 Ser Asp Ser Glu Gly Phe Ser Arg Lys Ser Pro Ser Ala Ile Ser Thr
          15                  20                  25

 ggc aca ttg gtc agt aag aga gaa gta gag cta gaa aaa aac aca aag      627
 Gly Thr Leu Val Ser Lys Arg Glu Val Glu Leu Glu Lys Asn Thr Lys
      30                  35                  40

 gag gaa gag gac ctt cgc aaa cgg aat cga gaa aga aac atc gaa act      675
 Glu Glu Glu Asp Leu Arg Lys Arg Asn Arg Glu Arg Asn Ile Glu Thr
  45                  50                  55                  60

 ggg aaa gat gat ggt ttg act gat gca cag caa cag ttt tca gtg aaa      723
 Gly Lys Asp Asp Gly Leu Thr Asp Ala Gln Gln Gln Phe Ser Val Lys
                  65                  70                  75

 gaa aca aac ttt tca gag gga att tta aaa ttg aaa att ggc ctc cag      771
 Glu Thr Asn Phe Ser Glu Gly Ile Leu Lys Leu Lys Ile Gly Leu Gln
              80                  85                  90

 gct aag aga act aaa aaa cct cca aag aac ttg gag aac tat gta tgt      819
 Ala Lys Arg Thr Lys Lys Pro Pro Lys Asn Leu Glu Asn Tyr Val Cys
          95                 100                 105

 cga cct gcc ata aaa aca act att aag cac cca agg aaa gca ctt aaa      867
 Arg Pro Ala Ile Lys Thr Thr Ile Lys His Pro Arg Lys Ala Leu Lys
     110                 115                 120

 agt gga aag atg acg gat gaa aag aat gaa cac tgt cct tca aaa cga      915
 Ser Gly Lys Met Thr Asp Glu Lys Asn Glu His Cys Pro Ser Lys Arg
 125                 130                 135                 140

 gac cct tca aag ttg tac aag aaa gca gat gat gtt gca gcc att gaa      963
 Asp Pro Ser Lys Leu Tyr Lys Lys Ala Asp Asp Val Ala Ala Ile Glu
                 145                 150                 155

 tgc cag tct gaa gaa gtc atc cgt ctt cat tca cag gga gaa aac aat     1011
 Cys Gln Ser Glu Glu Val Ile Arg Leu His Ser Gln Gly Glu Asn Asn
             160                 165                 170

 cct ttg tct aag aag ctg tct cca gta cac tca gaa atg gca gat tat     1059
 Pro Leu Ser Lys Lys Leu Ser Pro Val His Ser Glu Met Ala Asp Tyr
         175                 180                 185

 att aat gca acg cca tct act ctt ctt ggt agc cgg gat cct gat tta     1107
 Ile Asn Ala Thr Pro Ser Thr Leu Leu Gly Ser Arg Asp Pro Asp Leu
     190                 195                 200

 aag gac aga gca tta ctt aat gga gga act agt gta aca gaa aag ttg     1155
 Lys Asp Arg Ala Leu Leu Asn Gly Gly Thr Ser Val Thr Glu Lys Leu
 205                 210                 215                 220

 gca cag ctg att gct acc tgt cct cct tcc aag tct tcc aag aca aaa     1203
 Ala Gln Leu Ile Ala Thr Cys Pro Pro Ser Lys Ser Ser Lys Thr Lys
                 225                 230                 235

 ccg aag aag tta gga act ggc act aca gca gga ttg gtt agc aag gat     1251
 Pro Lys Lys Leu Gly Thr Gly Thr Thr Ala Gly Leu Val Ser Lys Asp
             240                 245                 250

 ttg atc agg aaa gca ggt gtt ggc tct gta gct gga ata ata cat aag     1299
 Leu Ile Arg Lys Ala Gly Val Gly Ser Val Ala Gly Ile Ile His Lys
         255                 260                 265

 gac tta ata aaa aag cca acc atc agc aca gca gtt gga ttg gta act     1347
 Asp Leu Ile Lys Lys Pro Thr Ile Ser Thr Ala Val Gly Leu Val Thr
     270                 275                 280

 aaa gat cct ggg aaa aag cca gtg ttt aat gca gca gta gga ttg gtc     1395
 Lys Asp Pro Gly Lys Lys Pro Val Phe Asn Ala Ala Val Gly Leu Val
 285                 290                 295                 300

 aat aag gac tct gtg aaa aaa ctg gga act ggc act aca gcg gta ttc     1443
 Asn Lys Asp Ser Val Lys Lys Leu Gly Thr Gly Thr Thr Ala Val Phe
                 305                 310                 315

 att aat aaa aac tta ggc aaa aag cca gga act atc act aca gta gga     1491
 Ile Asn Lys Asn Leu Gly Lys Lys Pro Gly Thr Ile Thr Thr Val Gly
             320                 325                 330

 ctg cta agc aaa gat tca gga aag aag cta gga att ggt att gtt cca     1539
 Leu Leu Ser Lys Asp Ser Gly Lys Lys Leu Gly Ile Gly Ile Val Pro
         335                 340                 345

 ggt tta gtg cat aaa gag tct ggc aag aag tta gga ctt ggc act gtg     1587
 Gly Leu Val His Lys Glu Ser Gly Lys Lys Leu Gly Leu Gly Thr Val
     350                 355                 360

 gtt gga ctg gtt aat aaa gat ttg gga aag aaa ttg ggt tct act gtt     1635
 Val Gly Leu Val Asn Lys Asp Leu Gly Lys Lys Leu Gly Ser Thr Val
 365                 370                 375                 380

 ggc cta gtg gcc aag gac tgt gca aag aag att gta gca agt tca gca     1683
 Gly Leu Val Ala Lys Asp Cys Ala Lys Lys Ile Val Ala Ser Ser Ala
                 385                 390                 395

 atg gga ttg gtt aat aag gac att gga aag aaa cta atg agt tgt cct     1731
 Met Gly Leu Val Asn Lys Asp Ile Gly Lys Lys Leu Met Ser Cys Pro
             400                 405                 410

 ttg gca ggt ctg atc agt aaa gat gcc ata aac ctt aaa gcc gaa gca     1779
 Leu Ala Gly Leu Ile Ser Lys Asp Ala Ile Asn Leu Lys Ala Glu Ala
         415                 420                 425

 ctg ctc ccc act cag gaa ccg ctt aag gct tct tgt agt aca aac atc     1827
 Leu Leu Pro Thr Gln Glu Pro Leu Lys Ala Ser Cys Ser Thr Asn Ile
     430                 435                 440

 aat aat cag gaa agt cag gaa ctt tct gaa tcc ctg aaa gat agt gcc     1875
 Asn Asn Gln Glu Ser Gln Glu Leu Ser Glu Ser Leu Lys Asp Ser Ala
 445                 450                 455                 460

 acc agc aaa act ttt gaa aag aat gtt gta cgg cag aat aaa gaa agc     1923
 Thr Ser Lys Thr Phe Glu Lys Asn Val Val Arg Gln Asn Lys Glu Ser
                 465                 470                 475

 ata ttg gaa aag ttc tca gta cga aaa gaa atc att aat ttg gag aaa     1971
 Ile Leu Glu Lys Phe Ser Val Arg Lys Glu Ile Ile Asn Leu Glu Lys
             480                 485                 490

 gaa atg ttt aat gaa gga aca tgc att cag caa gac agt ttc tca tcc     2019
 Glu Met Phe Asn Glu Gly Thr Cys Ile Gln Gln Asp Ser Phe Ser Ser
         495                 500                 505

 agt gaa aag gga tct tat gaa acc tca aag cat gaa aag cag cct cct     2067
 Ser Glu Lys Gly Ser Tyr Glu Thr Ser Lys His Glu Lys Gln Pro Pro
     510                 515                 520

 gta tat tgc act tct ccg gac ttt aaa atg gga ggt gct tct gat gta     2115
 Val Tyr Cys Thr Ser Pro Asp Phe Lys Met Gly Gly Ala Ser Asp Val
 525                 530                 535                 540

 tct acc gct aaa tcc cca ttc agt gca gta gga gaa agc aat ctc cct     2163
 Ser Thr Ala Lys Ser Pro Phe Ser Ala Val Gly Glu Ser Asn Leu Pro
                 545                 550                 555

 tcc cca tca cct act gta tct gtt aat cct tta acc aga agt ccc cct     2211
 Ser Pro Ser Pro Thr Val Ser Val Asn Pro Leu Thr Arg Ser Pro Pro
             560                 565                 570

 gaa att tct tca cag ttg gct cct aat cca tta ctt tta agt tct act     2259
 Glu Ile Ser Ser Gln Leu Ala Pro Asn Pro Leu Leu Leu Ser Ser Thr
         575                 580                 585

 aca gaa cta atc gaa gaa gtt tct gaa tct gtt gga aag aac cag ttt     2307
 Thr Glu Leu Ile Glu Glu Val Ser Glu Ser Val Gly Lys Asn Gln Phe
     590                 595                 600

 act tct gaa agt acc cac ttg aac gtt ggt cat agg tca gtt ggt cat     2355
 Thr Ser Glu Ser Thr His Leu Asn Val Gly His Arg Ser Val Gly His
 605                 610                 615                 620

 agt ata agt att gaa tgt aaa ggg att gat aaa gag gta aat gat tca     2403
 Ser Ile Ser Ile Glu Cys Lys Gly Ile Asp Lys Glu Val Asn Asp Ser
                 625                 630                 635

 aaa act acc cat ata gat att cca aga ata agc tct tcc ctt gga aaa     2451
 Lys Thr Thr His Ile Asp Ile Pro Arg Ile Ser Ser Ser Leu Gly Lys
             640                 645                 650

 aag cca agt ttg act tct gaa tcc agc att cat act att act cct tca     2499
 Lys Pro Ser Leu Thr Ser Glu Ser Ser Ile His Thr Ile Thr Pro Ser
         655                 660                 665

 gtt gtt aac ttc act agt tta ttt agt aat aag cct ttt tta aaa ctg     2547
 Val Val Asn Phe Thr Ser Leu Phe Ser Asn Lys Pro Phe Leu Lys Leu
     670                 675                 680

 ggt gca gta tct gca tca gac aaa cac tgc caa gtt gct gaa agc cta     2595
 Gly Ala Val Ser Ala Ser Asp Lys His Cys Gln Val Ala Glu Ser Leu
 685                 690                 695                 700

 agt act agt ttg cag tcc aaa cca tta aaa aaa aga aaa gga aga aaa     2643
 Ser Thr Ser Leu Gln Ser Lys Pro Leu Lys Lys Arg Lys Gly Arg Lys
                 705                 710                 715

 cct cgg tgg act aaa gtg gtg gca aga agc aca tgc cgg tct cca aaa     2691
 Pro Arg Trp Thr Lys Val Val Ala Arg Ser Thr Cys Arg Ser Pro Lys
             720                 725                 730

 ggg cta gaa tta gaa aga tca gag ctt ttt aaa aac gtt tca tgt agc     2739
 Gly Leu Glu Leu Glu Arg Ser Glu Leu Phe Lys Asn Val Ser Cys Ser
         735                 740                 745

 tca cta tca aat agt aat tct gag cca gcc aag ttt atg aaa aac att     2787
 Ser Leu Ser Asn Ser Asn Ser Glu Pro Ala Lys Phe Met Lys Asn Ile
     750                 755                 760

 gga ccc cct tca ttt gta gat cat gac ttc ctt aaa cgc cga ttg cca     2835
 Gly Pro Pro Ser Phe Val Asp His Asp Phe Leu Lys Arg Arg Leu Pro
 765                 770                 775                 780

 aag ttg agc aaa tcc aca gct cca tct ctt gct ctc tta gct gat agt     2883
 Lys Leu Ser Lys Ser Thr Ala Pro Ser Leu Ala Leu Leu Ala Asp Ser
                 785                 790                 795

 gaa aaa cca tct cat aag tct ttt gct act cac aaa cta tcc tcc agt     2931
 Glu Lys Pro Ser His Lys Ser Phe Ala Thr His Lys Leu Ser Ser Ser
             800                 805                 810

 atg tgt gtc tct agt gac ctt ttg tct gat att tat aag ccc aaa aga     2979
 Met Cys Val Ser Ser Asp Leu Leu Ser Asp Ile Tyr Lys Pro Lys Arg
         815                 820                 825

 gga agg cct aaa tct aag gag atg cct caa ctg gaa ggg cca cct aaa     3027
 Gly Arg Pro Lys Ser Lys Glu Met Pro Gln Leu Glu Gly Pro Pro Lys
     830                 835                 840

 agg act tta aaa atc cct gct tct aaa gtg ttt tct tta cag tct aag     3075
 Arg Thr Leu Lys Ile Pro Ala Ser Lys Val Phe Ser Leu Gln Ser Lys
 845                 850                 855                 860

 gaa gaa caa gaa ccc cca att tta cag cca gaa att gaa atc cct tcc     3123
 Glu Glu Gln Glu Pro Pro Ile Leu Gln Pro Glu Ile Glu Ile Pro Ser
                 865                 870                 875

 ttc aaa caa ggt ctg tct gtg tct cct ttt cca aaa aag aga ggc agg     3171
 Phe Lys Gln Gly Leu Ser Val Ser Pro Phe Pro Lys Lys Arg Gly Arg
             880                 885                 890

 cct aag agg caa atg agg tca cca gtc aag atg aag cca cct gta ctg     3219
 Pro Lys Arg Gln Met Arg Ser Pro Val Lys Met Lys Pro Pro Val Leu
         895                 900                 905

 tca gtg gct cca ttt gtt gcc act gaa agt cca agc aag cta gaa tct     3267
 Ser Val Ala Pro Phe Val Ala Thr Glu Ser Pro Ser Lys Leu Glu Ser
     910                 915                 920

 gaa agt gac aac cat aga agt agc agt gat ttc ttt gag agc gag gat     3315
 Glu Ser Asp Asn His Arg Ser Ser Ser Asp Phe Phe Glu Ser Glu Asp
 925                 930                 935                 940

 caa ctt cag gat cca gat gac cta gat gac agt cat agg cca agt gtc     3363
 Gln Leu Gln Asp Pro Asp Asp Leu Asp Asp Ser His Arg Pro Ser Val
                 945                 950                 955

 tgt agt atg agt gac ctt gag atg gaa cca gat aaa aaa att acc aag     3411
 Cys Ser Met Ser Asp Leu Glu Met Glu Pro Asp Lys Lys Ile Thr Lys
             960                 965                 970

 aga aac aat gga caa tta atg aaa aca att atc cgc aaa ata aat aaa     3459
 Arg Asn Asn Gly Gln Leu Met Lys Thr Ile Ile Arg Lys Ile Asn Lys
         975                 980                 985

 atg aag act tta aag aga aag aaa ctg ttg aat cag att ctt tca agt     3507
 Met Lys Thr Leu Lys Arg Lys Lys Leu Leu Asn Gln Ile Leu Ser Ser
     990                 995                1000

 tct gta gaa tca agt aat aaa ggg aaa gtg caa tcc aaa ctc cat aat     3555
 Ser Val Glu Ser Ser Asn Lys Gly Lys Val Gln Ser Lys Leu His Asn
1005                1010                1015                1020

 acg gta tca agt ctt gct gcc aca ttt ggc tct aaa ttg ggc caa cag     3603
 Thr Val Ser Ser Leu Ala Ala Thr Phe Gly Ser Lys Leu Gly Gln Gln
                1025                1030                1035

 ata aat gtc agc aag aaa gga acc att tat ata gga aag aga aga ggt     3651
 Ile Asn Val Ser Lys Lys Gly Thr Ile Tyr Ile Gly Lys Arg Arg Gly
            1040                1045                1050

 cgc aaa cca aaa act gtc tta aat ggt att ctt tct ggt agt cct act     3699
 Arg Lys Pro Lys Thr Val Leu Asn Gly Ile Leu Ser Gly Ser Pro Thr
        1055                1060                1065

 agc ctt gct gtt ctt gag caa aca gct caa cag gca gct ggg tca gca     3747
 Ser Leu Ala Val Leu Glu Gln Thr Ala Gln Gln Ala Ala Gly Ser Ala
    1070                1075                1080

 tta gga cag att ctt ccc cca tta ctg cct tca tct gct agt agt tct     3795
 Leu Gly Gln Ile Leu Pro Pro Leu Leu Pro Ser Ser Ala Ser Ser Ser
1085                1090                1095                1100

 gag att ctt cca tca cct att tgc tct cag tct tct ggg act agt gga     3843
 Glu Ile Leu Pro Ser Pro Ile Cys Ser Gln Ser Ser Gly Thr Ser Gly
                1105                1110                1115

 ggt cag agc cct gta agt agt gat gca ggt ttt gtt gaa ccc agt tca     3891
 Gly Gln Ser Pro Val Ser Ser Asp Ala Gly Phe Val Glu Pro Ser Ser
            1120                1125                1130

 gtg cca tat ttg cat tta cac tcc aga cag ggc agt atg att cag act     3939
 Val Pro Tyr Leu His Leu His Ser Arg Gln Gly Ser Met Ile Gln Thr
        1135                1140                1145

 ctt gca atg aag aag gcc tca aag ggg agg agg cgg tta tct cct cct     3987
 Leu Ala Met Lys Lys Ala Ser Lys Gly Arg Arg Arg Leu Ser Pro Pro
    1150                1155                1160

 act ttg ttg cca aat tct cct tcg cac ttg agt gaa ctc aca tct cta     4035
 Thr Leu Leu Pro Asn Ser Pro Ser His Leu Ser Glu Leu Thr Ser Leu
1165                1170                1175                1180

 aaa gaa gct act cct tcc cca atc agt gag tct cat agt gat gag acc     4083
 Lys Glu Ala Thr Pro Ser Pro Ile Ser Glu Ser His Ser Asp Glu Thr
                1185                1190                1195

 att ccc agt gat agt gga att gga aca gat aat aac agc aca tca gac     4131
 Ile Pro Ser Asp Ser Gly Ile Gly Thr Asp Asn Asn Ser Thr Ser Asp
            1200                1205                1210

 agg gca gag aaa ttt tgt ggg caa aaa aag agg agg cat tct ttt gag     4179
 Arg Ala Glu Lys Phe Cys Gly Gln Lys Lys Arg Arg His Ser Phe Glu
        1215                1220                1225

 cat gtt tct ctg att ccc cct gaa acc tct aca gtg cta agc agt ctt     4227
 His Val Ser Leu Ile Pro Pro Glu Thr Ser Thr Val Leu Ser Ser Leu
    1230                1235                1240

 aaa gaa aaa cat aaa cac aaa tgt aag cgc agg aat cat gat tac ctc     4275
 Lys Glu Lys His Lys His Lys Cys Lys Arg Arg Asn His Asp Tyr Leu
1245                1250                1255                1260

 agc tat gac aag atg aaa agg cag aaa cga aaa cgg aaa aag aaa tat     4323
 Ser Tyr Asp Lys Met Lys Arg Gln Lys Arg Lys Arg Lys Lys Lys Tyr
                1265                1270                1275

 ccc cag ctt cga aat aga cag gat cca gac ttt att gca gag ctg gag     4371
 Pro Gln Leu Arg Asn Arg Gln Asp Pro Asp Phe Ile Ala Glu Leu Glu
            1280                1285                1290

 gaa cta ata agt cgc cta agt gaa att cgg atc act cat cga agt cat     4419
 Glu Leu Ile Ser Arg Leu Ser Glu Ile Arg Ile Thr His Arg Ser His
        1295                1300                1305

 cat ttt atc ccc cga gat ctt ctg cca act atc ttt cga atc aac ttt     4467
 His Phe Ile Pro Arg Asp Leu Leu Pro Thr Ile Phe Arg Ile Asn Phe
    1310                1315                1320

 aat agt ttc tat aca cat cct tct ttc ccc tta gac cct ttg cac tac     4515
 Asn Ser Phe Tyr Thr His Pro Ser Phe Pro Leu Asp Pro Leu His Tyr
1325                1330                1335                1340

 att cga aaa cct gac tta aaa aag aaa aga ggg aga ccc cct aag atg     4563
 Ile Arg Lys Pro Asp Leu Lys Lys Lys Arg Gly Arg Pro Pro Lys Met
                1345                1350                1355

 agg gag gca atg gct gaa atg cct ttt atg cac agc ctt agt ttt cct     4611
 Arg Glu Ala Met Ala Glu Met Pro Phe Met His Ser Leu Ser Phe Pro
            1360                1365                1370

 ctt tct agt act gga ttc tat cca tct tat ggt atg cct tac tct cct     4659
 Leu Ser Ser Thr Gly Phe Tyr Pro Ser Tyr Gly Met Pro Tyr Ser Pro
        1375                1380                1385

 tca ccc ctt aca gct gct ccc ata gga tta ggt tac tat gga agg tat     4707
 Ser Pro Leu Thr Ala Ala Pro Ile Gly Leu Gly Tyr Tyr Gly Arg Tyr
    1390                1395                1400

 cct ccc act ctt tat cca cct cct cca tct cct tct ttc acc acg cca     4755
 Pro Pro Thr Leu Tyr Pro Pro Pro Pro Ser Pro Ser Phe Thr Thr Pro
1405                1410                1415                1420

 ctt cca cct cct tcc tat atg cat gct ggt cat tta ctt ctc aat cct     4803
 Leu Pro Pro Pro Ser Tyr Met His Ala Gly His Leu Leu Leu Asn Pro
                1425                1430                1435

 gcc aaa tac cat aag aaa aag cat aag cta ctt cga cag gag gcc ttt     4851
 Ala Lys Tyr His Lys Lys Lys His Lys Leu Leu Arg Gln Glu Ala Phe
            1440                1445                1450

 ctt aca acc agc agg act ccc ctc ctt tcc atg agt acc tac ccc agt     4899
 Leu Thr Thr Ser Arg Thr Pro Leu Leu Ser Met Ser Thr Tyr Pro Ser
        1455                1460                1465

 gtt cct cct gag atg gcc tat ggt tgg atg gtt gag cac aaa cac agg     4947
 Val Pro Pro Glu Met Ala Tyr Gly Trp Met Val Glu His Lys His Arg
    1470                1475                1480

 cac cgt cac aaa cac aga gaa cac cgt tct tct gaa caa ccc cag gtt     4995
 His Arg His Lys His Arg Glu His Arg Ser Ser Glu Gln Pro Gln Val
1485                1490                1495                1500

 tct atg gac act ggc tct tcc cga tct gtc ctg gaa tct ttg aag cgc     5043
 Ser Met Asp Thr Gly Ser Ser Arg Ser Val Leu Glu Ser Leu Lys Arg
                1505                1510                1515

 tat aga ttt gga aag gat gct gtt gga gag cga tat aag cat aag gaa     5091
 Tyr Arg Phe Gly Lys Asp Ala Val Gly Glu Arg Tyr Lys His Lys Glu
            1520                1525                1530

 aag cac cgt tgt cac atg tcc tgc cct cat ctc tct cct tca aaa agc     5139
 Lys His Arg Cys His Met Ser Cys Pro His Leu Ser Pro Ser Lys Ser
        1535                1540                1545

 tta ata aac aga gag gaa cag tgg gtc cac cga gag cct tca gaa tct     5187
 Leu Ile Asn Arg Glu Glu Gln Trp Val His Arg Glu Pro Ser Glu Ser
    1550                1555                1560

 agt cca ttg gcc ttg gga ttg cag aca cct tta cag att gac tgt tca     5235
 Ser Pro Leu Ala Leu Gly Leu Gln Thr Pro Leu Gln Ile Asp Cys Ser
1565                1570                1575                1580

 gaa agt tct cca agc tta tcc ctt gga gga ttc act ccc aac tct gag     5283
 Glu Ser Ser Pro Ser Leu Ser Leu Gly Gly Phe Thr Pro Asn Ser Glu
                1585                1590                1595

 cca gcc agc agt gat gaa cat aca aac ctt ttc aca agt gca ata ggc     5331
 Pro Ala Ser Ser Asp Glu His Thr Asn Leu Phe Thr Ser Ala Ile Gly
            1600                1605                1610

 agc tgc aga gtt tca aac cct aac tcc agt ggc cgg aag aaa tta act     5379
 Ser Cys Arg Val Ser Asn Pro Asn Ser Ser Gly Arg Lys Lys Leu Thr
        1615                1620                1625

 gac agc cct gga ctc ttt tct gca cag gac act tca cta aat cgg ctt     5427
 Asp Ser Pro Gly Leu Phe Ser Ala Gln Asp Thr Ser Leu Asn Arg Leu
    1630                1635                1640

 cac aga aag gag tca ctg cct tct aac gaa agg gca gta cag act ttg     5475
 His Arg Lys Glu Ser Leu Pro Ser Asn Glu Arg Ala Val Gln Thr Leu
1645                1650                1655                1660

 gca ggc tcc cag cca acc tct gat aaa ccc tcc cag cgg cca tca gag     5523
 Ala Gly Ser Gln Pro Thr Ser Asp Lys Pro Ser Gln Arg Pro Ser Glu
                1665                1670                1675

 agc aca aat tgt agc cct acc cgg aaa agg tct tca tct gag agt act     5571
 Ser Thr Asn Cys Ser Pro Thr Arg Lys Arg Ser Ser Ser Glu Ser Thr
            1680                1685                1690

 tct tca aca gta aac gga gtt ccc tct cga agt cca aga tta gtt gct     5619
 Ser Ser Thr Val Asn Gly Val Pro Ser Arg Ser Pro Arg Leu Val Ala
        1695                1700                1705

 tct ggg gat gac tct gtg gat agt ctg ctg cag cgg atg gta caa aat     5667
 Ser Gly Asp Asp Ser Val Asp Ser Leu Leu Gln Arg Met Val Gln Asn
    1710                1715                1720

 gag gac caa gag ccc atg gag aaa agt att gat gct gtg att gca act     5715
 Glu Asp Gln Glu Pro Met Glu Lys Ser Ile Asp Ala Val Ile Ala Thr
1725                1730                1735                1740

 gcc tct gca cca cct tct tcc agt cca ggc cgt agc cac agc aag gac     5763
 Ala Ser Ala Pro Pro Ser Ser Ser Pro Gly Arg Ser His Ser Lys Asp
                1745                1750                1755

 cga acc ctg gga aaa cca gac agc ctt tta gtg cct gca gtc gca agt     5811
 Arg Thr Leu Gly Lys Pro Asp Ser Leu Leu Val Pro Ala Val Ala Ser
            1760                1765                1770

 gac tct tgc aat aat agc atc tca ctc cta tct gaa aag ttg aca agc     5859
 Asp Ser Cys Asn Asn Ser Ile Ser Leu Leu Ser Glu Lys Leu Thr Ser
        1775                1780                1785

 agc tgt tcc ccc cat cat atc aag aga agt gta gtg gaa gct atg caa     5907
 Ser Cys Ser Pro His His Ile Lys Arg Ser Val Val Glu Ala Met Gln
    1790                1795                1800

 cgc caa gct cgg aaa atg tgc aat tac gac aaa atc ttg gcc aca aag     5955
 Arg Gln Ala Arg Lys Met Cys Asn Tyr Asp Lys Ile Leu Ala Thr Lys
1805                1810                1815                1820

 aaa aac cta gac cat gtc aat aaa atc tta aaa gcc aaa aaa ctt caa     6003
 Lys Asn Leu Asp His Val Asn Lys Ile Leu Lys Ala Lys Lys Leu Gln
                1825                1830                1835

 agg cag gcc agg aca ggg aat aac ttt gtg aaa cgt agg cca ggt cga     6051
 Arg Gln Ala Arg Thr Gly Asn Asn Phe Val Lys Arg Arg Pro Gly Arg
            1840                1845                1850

 cct cgg aaa tgt ccc ctt cag gct gtc gta tca atg caa gca ttc cag     6099
 Pro Arg Lys Cys Pro Leu Gln Ala Val Val Ser Met Gln Ala Phe Gln
        1855                1860                1865

 gct gct cag ttt gtc aac cca gaa ttg aac aga gac gag gaa gga gca     6147
 Ala Ala Gln Phe Val Asn Pro Glu Leu Asn Arg Asp Glu Glu Gly Ala
    1870                1875                1880

 gca ctg cac ctc agt cct gac aca gtt aca gat gta att gag gct gtt     6195
 Ala Leu His Leu Ser Pro Asp Thr Val Thr Asp Val Ile Glu Ala Val
1885                1890                1895                1900

 gtt cag agt gta aat ctg aac cca gaa cat aaa aag ggg ttg aag aga     6243
 Val Gln Ser Val Asn Leu Asn Pro Glu His Lys Lys Gly Leu Lys Arg
                1905                1910                1915

 aaa ggt tgg cta ttg gaa gaa cag acc aga aaa aag cag aag cca tta     6291
 Lys Gly Trp Leu Leu Glu Glu Gln Thr Arg Lys Lys Gln Lys Pro Leu
            1920                1925                1930

 cca gag gaa gaa gag caa gag aat aat aaa agc ttt aat gaa gca cca     6339
 Pro Glu Glu Glu Glu Gln Glu Asn Asn Lys Ser Phe Asn Glu Ala Pro
        1935                1940                1945

 gtt gag att ccc agt cct tct gaa acc cca gct aaa cct tct gaa cct     6387
 Val Glu Ile Pro Ser Pro Ser Glu Thr Pro Ala Lys Pro Ser Glu Pro
    1950                1955                1960

 gaa agt acc ttg cag cct gtg ctt tct ctc atc cca agg gaa aag aag     6435
 Glu Ser Thr Leu Gln Pro Val Leu Ser Leu Ile Pro Arg Glu Lys Lys
1965                1970                1975                1980

 ccc cca cgt ccc cca aag aag aag tat cag aaa gca ggg ctg tat tct     6483
 Pro Pro Arg Pro Pro Lys Lys Lys Tyr Gln Lys Ala Gly Leu Tyr Ser
                1985                1990                1995

 gac gtt tac aaa act aca gac cca aag agt cga ttg atc caa tta aag     6531
 Asp Val Tyr Lys Thr Thr Asp Pro Lys Ser Arg Leu Ile Gln Leu Lys
            2000                2005                2010

 aaa gag aag ctg gag tat act cca gga gag cat gaa tat gga tta ttt     6579
 Lys Glu Lys Leu Glu Tyr Thr Pro Gly Glu His Glu Tyr Gly Leu Phe
        2015                2020                2025

 cca gcg ccc att cat gtt gtg ttt ttt gtt tca gga aag tat cta aga     6627
 Pro Ala Pro Ile His Val Val Phe Phe Val Ser Gly Lys Tyr Leu Arg
    2030                2035                2040

 caa aag aga att gac ttc cag ctt cct tat gat atc ctt tgg cag tgg     6675
 Gln Lys Arg Ile Asp Phe Gln Leu Pro Tyr Asp Ile Leu Trp Gln Trp
2045                2050                2055                2060

 aaa cac aat cag cta tac aaa aag cca gat gtc cca cta tat aag aaa     6723
 Lys His Asn Gln Leu Tyr Lys Lys Pro Asp Val Pro Leu Tyr Lys Lys
                2065                2070                2075

 att cgt tca aat gtc tac gtt gat gtc aaa ccc ctt tct ggt tac gaa     6771
 Ile Arg Ser Asn Val Tyr Val Asp Val Lys Pro Leu Ser Gly Tyr Glu
            2080                2085                2090

 gct acc acc tgt aac tgt aag aag cca gat gat gac acc agg aag ggc     6819
 Ala Thr Thr Cys Asn Cys Lys Lys Pro Asp Asp Asp Thr Arg Lys Gly
        2095                2100                2105

 tgt gtt gat gac tgc ctc aat aga atg atc ttt gct gag tgt tcc ccc     6867
 Cys Val Asp Asp Cys Leu Asn Arg Met Ile Phe Ala Glu Cys Ser Pro
    2110                2115                2120

 aac act tgc cca tgt ggc gag caa tgc tgt aac cag agg ata cag agg     6915
 Asn Thr Cys Pro Cys Gly Glu Gln Cys Cys Asn Gln Arg Ile Gln Arg
2125                2130                2135                2140

 cat gaa tgg gtg caa tgt cta gaa cga ttt cga gct gag gaa aaa ggt     6963
 His Glu Trp Val Gln Cys Leu Glu Arg Phe Arg Ala Glu Glu Lys Gly
                2145                2150                2155

 tgg gga atc aga acc aaa gag ccc cta aaa gct ggg cag ttc atc att     7011
 Trp Gly Ile Arg Thr Lys Glu Pro Leu Lys Ala Gly Gln Phe Ile Ile
            2160                2165                2170

 gaa tac cta ggg gag gtc gtc agt gaa cag gag ttc agg aac agg atg     7059
 Glu Tyr Leu Gly Glu Val Val Ser Glu Gln Glu Phe Arg Asn Arg Met
        2175                2180                2185

 att gag cag tat cat aat cac agt gac cac tac tgc ctg aac ctg gat     7107
 Ile Glu Gln Tyr His Asn His Ser Asp His Tyr Cys Leu Asn Leu Asp
    2190                2195                2200

 agt ggg atg gtg att gac agt tac cgc atg gga aat gag gcc cga ttc     7155
 Ser Gly Met Val Ile Asp Ser Tyr Arg Met Gly Asn Glu Ala Arg Phe
2205                2210                2215                2220

 atc aac cat agc tgt gac cca aat tgt gaa atg cag aaa tgg tct gtt     7203
 Ile Asn His Ser Cys Asp Pro Asn Cys Glu Met Gln Lys Trp Ser Val
                2225                2230                2235

 aat gga gta tac cgg att gga ctc tat gct ctt aaa gac atg cca gct     7251
 Asn Gly Val Tyr Arg Ile Gly Leu Tyr Ala Leu Lys Asp Met Pro Ala
            2240                2245                2250

 ggg act gaa ctc act tat gat tat aac ttt cat tcc ttc aat gtg gaa     7299
 Gly Thr Glu Leu Thr Tyr Asp Tyr Asn Phe His Ser Phe Asn Val Glu
        2255                2260                2265

 aaa cag caa ctt tgt aag tgt ggc ttt gag aaa tgt cga gga atc atc     7347
 Lys Gln Gln Leu Cys Lys Cys Gly Phe Glu Lys Cys Arg Gly Ile Ile
    2270                2275                2280

 gga ggc aag agt cag cgt gtg aat gga ctc acc agc agc aaa aac agc     7395
 Gly Gly Lys Ser Gln Arg Val Asn Gly Leu Thr Ser Ser Lys Asn Ser
2285                2290                2295                2300

 cag ccc atg gcc aca cac aaa aaa tct gga cgg tca aaa gag aag aga     7443
 Gln Pro Met Ala Thr His Lys Lys Ser Gly Arg Ser Lys Glu Lys Arg
                2305                2310                2315

 aag tct aag cac aag ctg aag aaa agg aga ggc cat ctc tct gag gaa     7491
 Lys Ser Lys His Lys Leu Lys Lys Arg Arg Gly His Leu Ser Glu Glu
            2320                2325                2330

 ccc agt gaa aat atc aac acc cca act aga ttg acc ccc caa tta cag     7539
 Pro Ser Glu Asn Ile Asn Thr Pro Thr Arg Leu Thr Pro Gln Leu Gln
        2335                2340                2345

 atg aag cca atg tcc aat cgt gaa agg aac ttt gtg tta aag cat cat     7587
 Met Lys Pro Met Ser Asn Arg Glu Arg Asn Phe Val Leu Lys His His
    2350                2355                2360

 gta ttc ttg gtc cga aac tgg gag aag att cgt caa aaa cag gag gaa     7635
 Val Phe Leu Val Arg Asn Trp Glu Lys Ile Arg Gln Lys Gln Glu Glu
2365                2370                2375                2380

 gta aag cac acc agt gat aat att cac tca gca tca tta tat acc cgt     7683
 Val Lys His Thr Ser Asp Asn Ile His Ser Ala Ser Leu Tyr Thr Arg
                2385                2390                2395

 tgg aat ggg atc tgc cga gat gat ggg aat atc aag tct gat gtc ttc     7731
 Trp Asn Gly Ile Cys Arg Asp Asp Gly Asn Ile Lys Ser Asp Val Phe
            2400                2405                2410

 atg acc cag ttc tct gcc ctg cag aca gct cga tct gtt cga aca aga     7779
 Met Thr Gln Phe Ser Ala Leu Gln Thr Ala Arg Ser Val Arg Thr Arg
        2415                2420                2425

 cgg ttg gca gct gca gag gaa aat att gaa gtg gct cgg gca gcc cgc     7827
 Arg Leu Ala Ala Ala Glu Glu Asn Ile Glu Val Ala Arg Ala Ala Arg
    2430                2435                2440

 cta gcc cag atc ttc aaa gaa att tgt gat ggt atc atc tct tat aaa     7875
 Leu Ala Gln Ile Phe Lys Glu Ile Cys Asp Gly Ile Ile Ser Tyr Lys
2445                2450                2455                2460

 gat tct tcc cgg caa gca ctg gca gct cca ctt ttg aac ctt ccc cca     7923
 Asp Ser Ser Arg Gln Ala Leu Ala Ala Pro Leu Leu Asn Leu Pro Pro
                2465                2470                2475

 aag aaa aag aat gct gat tat tat gag aag atc tct gat ccc cta gat     7971
 Lys Lys Lys Asn Ala Asp Tyr Tyr Glu Lys Ile Ser Asp Pro Leu Asp
            2480                2485                2490

 ctt atc acc ata gag aag cag atc ctc act ggt tac tat aag aca gtg     8019
 Leu Ile Thr Ile Glu Lys Gln Ile Leu Thr Gly Tyr Tyr Lys Thr Val
        2495                2500                2505

 gaa gct ttt gat gct gac atg ctc aaa gtc ttt cgg aat gct gag aag     8067
 Glu Ala Phe Asp Ala Asp Met Leu Lys Val Phe Arg Asn Ala Glu Lys
    2510                2515                2520

 tac tat ggg cgt aaa tcc cca gtt ggg aga gat gtt tgt cgt cta cga     8115
 Tyr Tyr Gly Arg Lys Ser Pro Val Gly Arg Asp Val Cys Arg Leu Arg
2525                2530                2535                2540

 aag gcc tat tac aat gcc cgg cat gag gca tca gcc cag att gat gag     8163
 Lys Ala Tyr Tyr Asn Ala Arg His Glu Ala Ser Ala Gln Ile Asp Glu
                2545                2550                2555

 att gtg gga gag aca gca agt gag gca gac agc agt gag acc tca gtc     8211
 Ile Val Gly Glu Thr Ala Ser Glu Ala Asp Ser Ser Glu Thr Ser Val
            2560                2565                2570

 tct gaa aag gag aat ggg cat gag aag gac gac gat gtt att cgc tgt     8259
 Ser Glu Lys Glu Asn Gly His Glu Lys Asp Asp Asp Val Ile Arg Cys
        2575                2580                2585

 atc tgt ggc ctc tac aac gat gaa ggt ctc atg atc cag tgt gac aag     8307
 Ile Cys Gly Leu Tyr Asn Asp Glu Gly Leu Met Ile Gln Cys Asp Lys
    2590                2595                2600

 tgc atg gta tgg cag cac tgt gat tgt atg gga gtg aac tca gat gtg     8355
 Cys Met Val Trp Gln His Cys Asp Cys Met Gly Val Asn Ser Asp Val
2605                2610                2615                2620

 gag cac tac ctt tgt gag cag tgt gac cca agg cct gtg gac agg gag     8403
 Glu His Tyr Leu Cys Glu Gln Cys Asp Pro Arg Pro Val Asp Arg Glu
                2625                2630                2635

 gtt ccc atg atc cct cgg ccc cac tat gcc caa cct ggc tgt gtc tac     8451
 Val Pro Met Ile Pro Arg Pro His Tyr Ala Gln Pro Gly Cys Val Tyr
            2640                2645                2650

 ttc atc tgt ttg ctc cga gat gac ttg ctg ctt cgt cag ggt gac tgt     8499
 Phe Ile Cys Leu Leu Arg Asp Asp Leu Leu Leu Arg Gln Gly Asp Cys
        2655                2660                2665

 gtg tat ctg atg agg gat agt cgg cgc acc cct gat ggc cac ccg gtc     8547
 Val Tyr Leu Met Arg Asp Ser Arg Arg Thr Pro Asp Gly His Pro Val
    2670                2675                2680

 cgt cag tcc tat cga ctg tta tct cac att aac cga cat aaa ctt gac     8595
 Arg Gln Ser Tyr Arg Leu Leu Ser His Ile Asn Arg His Lys Leu Asp
2685                2690                2695                2700

 atc ttt cgc att gag aag ctt tgg aag aat gaa aaa gag gaa cgg ttt     8643
 Ile Phe Arg Ile Glu Lys Leu Trp Lys Asn Glu Lys Glu Glu Arg Phe
                2705                2710                2715

 gcc ttt ggt cac cat tat ttc cgt ccc cac gaa aca cac cac tct cca     8691
 Ala Phe Gly His His Tyr Phe Arg Pro His Glu Thr His His Ser Pro
            2720                2725                2730

 tcc cgt cgg ttc tat cat aat gaa cta ttt cgg gtg cca ctc tat gag     8739
 Ser Arg Arg Phe Tyr His Asn Glu Leu Phe Arg Val Pro Leu Tyr Glu
        2735                2740                2745

 atc att ccc ttg gag gct gta gtg ggg acc tgc tgt gtg ttg gac ctt     8787
 Ile Ile Pro Leu Glu Ala Val Val Gly Thr Cys Cys Val Leu Asp Leu
    2750                2755                2760

 tat acg tat tgt aaa ggg aga ccc aaa gga gta aag gag caa gat gtg     8835
 Tyr Thr Tyr Cys Lys Gly Arg Pro Lys Gly Val Lys Glu Gln Asp Val
2765                2770                2775                2780

 tac atc tgt gat tat cgg ctt gac aag tca gca cac ctg ttt tac aag     8883
 Tyr Ile Cys Asp Tyr Arg Leu Asp Lys Ser Ala His Leu Phe Tyr Lys
                2785                2790                2795

 atc cac cgg aac cgc tat cct gtc tgc acc aaa ccc tat gct ttt gat     8931
 Ile His Arg Asn Arg Tyr Pro Val Cys Thr Lys Pro Tyr Ala Phe Asp
            2800                2805                2810

 cac ttc ccc aag aag ctc act ccc aaa aaa gat ttc tcg cct cat tac     8979
 His Phe Pro Lys Lys Leu Thr Pro Lys Lys Asp Phe Ser Pro His Tyr
        2815                2820                2825

 gtc cca gac aac tac aag agg aat gga gga cga tca tcc tgg aag tct     9027
 Val Pro Asp Asn Tyr Lys Arg Asn Gly Gly Arg Ser Ser Trp Lys Ser
    2830                2835                2840

 gag cgc tca aag cca ccc cta aaa gac ttg ggc cag gag gat gat gct     9075
 Glu Arg Ser Lys Pro Pro Leu Lys Asp Leu Gly Gln Glu Asp Asp Ala
2845                2850                2855                2860

 cta ccc ttg att gaa gag gtt cta gcc agt caa gag caa gca gcc aat     9123
 Leu Pro Leu Ile Glu Glu Val Leu Ala Ser Gln Glu Gln Ala Ala Asn
                2865                2870                2875

 gag ata ccc agc ctg gag gag cca gaa cgg gaa ggg gcc act gct aac     9171
 Glu Ile Pro Ser Leu Glu Glu Pro Glu Arg Glu Gly Ala Thr Ala Asn
            2880                2885                2890

 gtc agt gag ggt gaa aaa aaa aca gag gaa agt agt caa gaa ccc cag     9219
 Val Ser Glu Gly Glu Lys Lys Thr Glu Glu Ser Ser Gln Glu Pro Gln
        2895                2900                2905

 tca acc tgt acc cct gag gaa cga cgg cat aac caa cgg gaa cga ctc     9267
 Ser Thr Cys Thr Pro Glu Glu Arg Arg His Asn Gln Arg Glu Arg Leu
    2910                2915                2920

 aac cag atc ttg ctc aat ctc ctt gaa aaa atc cct gga aaa aat gcc     9315
 Asn Gln Ile Leu Leu Asn Leu Leu Glu Lys Ile Pro Gly Lys Asn Ala
2925                2930                2935                2940

 att gat gtg acc tac ttg ctg gag gaa gga tca ggc agg aaa ctg cga     9363
 Ile Asp Val Thr Tyr Leu Leu Glu Glu Gly Ser Gly Arg Lys Leu Arg
                2945                2950                2955

 agg cgt act ttg ttt atc cca gaa aac agc ttt cga aag tga             9405
 Arg Arg Thr Leu Phe Ile Pro Glu Asn Ser Phe Arg Lys 
            2960                2965





      <210> 106
      <211> 616
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (58)..(240)

      <400> 106
 gtagggagcg ctcagtctag gccccttgta tgtgcaggtc acaatagaat tcgatga        57                                                                 
 atg cag caa acc aac ata gct cat ttt aag ttc aaa ctc cca ggc tca      105
 Met Gln Gln Thr Asn Ile Ala His Phe Lys Phe Lys Leu Pro Gly Ser
   1               5                  10                  15

 agt gat cca ccc acc tca gct tcc cag gta gct aga act aaa agt gcg      153
 Ser Asp Pro Pro Thr Ser Ala Ser Gln Val Ala Arg Thr Lys Ser Ala
              20                  25                  30

 cac cac cac atg cag cta att ttt ttt gta gag atg ggg ttt tgc cat      201
 His His His Met Gln Leu Ile Phe Phe Val Glu Met Gly Phe Cys His
          35                  40                  45

 gtt gcc caa gct ggg tct cga aat cct ggg ctc aag tga tccgcctcct       250
 Val Ala Gln Ala Gly Ser Arg Asn Pro Gly Leu Lys 
      50                  55                  60

 ctggcttccc aaagcactag gaatacaggt gtgagccaac acatccggcc atggatgcat    310

 aggggtttac cagaagggaa gggtcacata ggaagtcaac tagtggaaaa aagcgtaagt    370

 gtttaggaac ctggaatctt tcctggaggg aaaagggtag gatttgtagg aagggaacgg    430

 gggtagaggg aggagataaa gcatgaaaga tacaccagta agagtgtgtc ctctggtgga    490

 tgctgaggtt aagaagaaaa aagagtggga ggactttgcc tagaaaggag tttgggcttt    550

 atctaggaga tacggatccc atgaaggatc tttactagag gagtattatt gtctcctcgt    610

 ccaagc                                                               616




      <210> 107
      <211> 1635
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (288)..(650)

      <400> 107
 ccggaattcc cgggtcgacg tttcgtggtg cgcctgcagg gatcggaagc cggttggggt     60

 gtgagaggtt ttctcgctct aggtaagcga aacaagccgg gggactgcga gccagggact    120

 cgggccgcgg ggcgggaaga agtggggcag cgcttggcca ggccgaaagg actttggggg    180

 tgggggctgg gagtccgtgt ctcgaatgag ggaggagagg tggagttgcc ggggctcagg    240

 cccggcctcg agcatgggcg gatgagagga gtcgggagcc gaggcct  atg gtc ctt     296
                                                      Met Val Leu
                                                        1

 cgg gtg agg gga gac gga gcc agc gag gag atg gag cag aag ctt gtg      344
 Arg Val Arg Gly Asp Gly Ala Ser Glu Glu Met Glu Gln Lys Leu Val
       5                  10                  15

 gag gag att ctt caa gca atc act atg tca aca gac aca ggt gtt tcc      392
 Glu Glu Ile Leu Gln Ala Ile Thr Met Ser Thr Asp Thr Gly Val Ser
  20                  25                  30                  35

 ctt cct tca tat gag gaa gat cag gga tca aaa ctc att cga aaa gct      440
 Leu Pro Ser Tyr Glu Glu Asp Gln Gly Ser Lys Leu Ile Arg Lys Ala
                  40                  45                  50

 aaa gag gca cca ttc gta ccc gtt gga ata gcg ggt ttt gca gca att      488
 Lys Glu Ala Pro Phe Val Pro Val Gly Ile Ala Gly Phe Ala Ala Ile
              55                  60                  65

 gtt gca tat gga tta tat aaa ctg aag agc agg gga aat act aaa atg      536
 Val Ala Tyr Gly Leu Tyr Lys Leu Lys Ser Arg Gly Asn Thr Lys Met
          70                  75                  80

 tcc att cat ctg atc cac atg cgt gtg gca gcc caa ggc ttt gtt gta      584
 Ser Ile His Leu Ile His Met Arg Val Ala Ala Gln Gly Phe Val Val
      85                  90                  95

 gga gca atg act gtt ggt atg ggc tat tcc atg tat cgg gaa ttc tgg      632
 Gly Ala Met Thr Val Gly Met Gly Tyr Ser Met Tyr Arg Glu Phe Trp
 100                 105                 110                 115

 gca aaa cct aag cct tag aagaag agatgctgtc ttggtcttgt tggaggagct      686
 Ala Lys Pro Lys Pro 
                 120

 tgctttagtt agatgtctta ttattaaagt tacctattat tgttggaaat aaactaattt    746

 gtatgggttt agatggtaac atggcatttt gaatattggc ttcctttctt gcaggcttga    806

 tttgcttggt gaccgaatta ctagtgacta gtttactaac taggtcattc aaggaagtca    866

 agttaactta aacatgtcac ctaaatgcac ttgatggtgt tgaaatgtcc accttcttaa    926

 atttttaaga tgaacttagt tctaaagaag ataacaggcc aatcctgaag gtactccctg    986

 tttgctgcag aatgtcagat attttggatg ttgcataaga gtcctatttg ccccagttaa   1046

 ttcaactttt gtctgcctgt tttgtggact ggctggctct gttagaactc tgtccaaaaa   1106

 gtgcatggaa tataacttgt aaagcttccc acaattgaca atatatatgc atgtgtttaa   1166

 accaaatcca gaaagcttaa acaatagagc tgcataatag tatttattaa agaatcacaa   1226

 ctgtaaacat gagaataact taaggattct agtttagttt tttgtaattg caaattatat   1286

 ttttgctgct gatatattag aataattttt aaatgtcatc ttgaaataga aatatgtatt   1346

 ttaagcactc acgcaaaggt aaatgaacac gttttaaatg tgtgtgttgc taattttttc   1406

 cataagaatt gtaaacattg aactgaacaa attacctata atggatttgg ttaatgactt   1466

 atgagcaagc tggtttggcc agacagtata cccaaacttt tatataatat acagaaggct   1526

 atcacacttg tgaaattctc ttgtctaatc tgaatttgca ttccatggtg ttaacatggt   1586

 atatgtattg ttattaaagt aagtgaccca tgtaaaaaaa aaaaaaaaa               1635




      <210> 108
      <211> 961
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (347)..(634)

      <400> 108
 gaggacaagc agcctgccca gaagtggaag aaactgaaag tggagtcctg agagctgaat     60

 ctgccgcagg cccgcgggcc gcccgggaat taggaaagtt agaggggatc cacgcccaca    120

 agtgctatgg actctgatcg cccaaccaga gcaaacccag aaggacaact ctccaagcct    180

 ttcaatcact cccactaacc cgtattgtgg acacactatt gtgaggccta ctaaggatgt    240

 actgctgatg accttttgaa gagtggctag tggttggccc atgtaggctg agctcagctg    300

 gtccatcctt cttggaccca cagactccct ggggcatgtt cttctc   atg atg atg     355
                                                      Met Met Met
                                                        1

 act gca aca cag agg gca aga cat cct aca caa gca cat ttc aag att      403
 Thr Ala Thr Gln Arg Ala Arg His Pro Thr Gln Ala His Phe Lys Ile
       5                  10                  15

 ttg ctc gca tca tct ctg cta aaa ttc ctt tat cca aag caa gga aca      451
 Leu Leu Ala Ser Ser Leu Leu Lys Phe Leu Tyr Pro Lys Gln Gly Thr
  20                  25                  30                  35

 caa ctg gtt caa ata agc aca ggc ctc caa ata tcc aga tct aaa aat      499
 Gln Leu Val Gln Ile Ser Thr Gly Leu Gln Ile Ser Arg Ser Lys Asn
                  40                  45                  50

 gga gtg ttc acc tca gct cct tat tta tca ctg caa gag att ctg ggg      547
 Gly Val Phe Thr Ser Ala Pro Tyr Leu Ser Leu Gln Glu Ile Leu Gly
              55                  60                  65

 ctg gca gct agt gac atg agc tgg aat cct ctt cct gaa att gct gtc      595
 Leu Ala Ala Ser Asp Met Ser Trp Asn Pro Leu Pro Glu Ile Ala Val
          70                  75                  80

 ttc ttg gat ggg ctc tcc aca tct tcc acc acg aag taa aaacaattct       644
 Phe Leu Asp Gly Leu Ser Thr Ser Ser Thr Thr Lys 
      85                  90                  95

 tgtgggtgcc agtggacctg ctctgcagac ccaggctcct ctcccatgga gcatcccaag    704

 tctgtcctta tgggaagaag caggagccct gtctggctgt accccaagct gctttctctg    764

 gaccaatgct gtcagcgata gagggaaccc ttccaccatc atgtgaagaa gcctggtcta    824

 gcctgctgga ggatgagaga tcacatggaa tgaggccaca atcgttccag ccaaagcccc    884

 agtaatagaa ttaagatcat ccaagaccat ggcatcccgc ctgagaagtt cagatgagaa    944

 gggccacctg aacaacc                                                   961




      <210> 109
      <211> 707
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (152)..(376)

      <400> 109
 catggacccc tttggaaccc tttcggaatt cccgggtcga cccacgcgtc cgcttccggt     60

 ccgctgagac tggggcctcg ctcgctcccg acccggttgc aagtgttgcg gtgggagaaa    120

 gtcgcgtccg catcggaggg gaagcgccgt c   atg cct aag tat tat gag gac     172
                                      Met Pro Lys Tyr Tyr Glu Asp
                                        1               5

 aag ccg cag ggc ggc gcg tgc gcg ggc ctg aag gag gac ctg ggc gcg      220
 Lys Pro Gln Gly Gly Ala Cys Ala Gly Leu Lys Glu Asp Leu Gly Ala
          10                  15                  20

 tgt ctg ctg cag tcg gac tgt gtg gtc cag gaa gga aaa tca cct cgg      268
 Cys Leu Leu Gln Ser Asp Cys Val Val Gln Glu Gly Lys Ser Pro Arg
      25                  30                  35

 cag tgt ttg aag gaa gga tac tgc aac tct ttg aag tac gca ttt ttt      316
 Gln Cys Leu Lys Glu Gly Tyr Cys Asn Ser Leu Lys Tyr Ala Phe Phe
  40                  45                  50                  55

 gag tgt aaa aga tca gtg ttg gat aac agg gca aga ttc aga gga aga      364
 Glu Cys Lys Arg Ser Val Leu Asp Asn Arg Ala Arg Phe Arg Gly Arg
                  60                  65                  70

 aaa gga tat tga tgc attatgttga agccaacatg gaaaacaaca aatattttcc      419
 Lys Gly Tyr 


 ctggtcatta acacaaagaa gccaaaacag gaaacatact ttttactaca tctgtttggt    479

 tggaccagat ttcccctccg tggaacactg aagaaagtgg atgagttgtt ttcgaatatg    539

 tataaagtaa atgattctct tgatccaagt tatttttaga agaaaaacct aattgaacag    599

 gtatgggttg ggagcataat aaatgtgttt tgagaattgt tctaaagcac agaaaatgga    659

 aagactgtta tttgcaaact tgactcttca attgaagtac ccaattag                 707




      <210> 110
      <211> 753
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (51)..(737)

      <400> 110
 atagaccaca tagggatttg gccctcgagc aggaattcgg cacgaggaag   atg gcg      56
                                                          Met Ala
                                                            1

 gcg gca gta ctg gga cag ttg ggt gcg tta tgg ata cat aac ctg agg      104
 Ala Ala Val Leu Gly Gln Leu Gly Ala Leu Trp Ile His Asn Leu Arg
           5                  10                  15

 agc cgg ggg aag ctg gcc ttg ggt gtt tta cct caa tca tat atc cac      152
 Ser Arg Gly Lys Leu Ala Leu Gly Val Leu Pro Gln Ser Tyr Ile His
      20                  25                  30

 aca agt gct tct ctt gac att tct cga aaa tgg gag aag aag aat aaa      200
 Thr Ser Ala Ser Leu Asp Ile Ser Arg Lys Trp Glu Lys Lys Asn Lys
  35                  40                  45                  50

 att gtt tat cct cca caa ctg cct gga gaa cct cgg aga cca gca gaa      248
 Ile Val Tyr Pro Pro Gln Leu Pro Gly Glu Pro Arg Arg Pro Ala Glu
                  55                  60                  65

 atc tac cac tgt cga aga caa ata aaa tat agc aaa gac aag atg tgg      296
 Ile Tyr His Cys Arg Arg Gln Ile Lys Tyr Ser Lys Asp Lys Met Trp
              70                  75                  80

 tat ttg gca aaa ttg ata cga gga atg tct att gac cag gct ttg gct      344
 Tyr Leu Ala Lys Leu Ile Arg Gly Met Ser Ile Asp Gln Ala Leu Ala
          85                  90                  95

 cag ttg gaa ttc aat gac aaa aaa ggg gcc aaa ata att aaa gag gtt      392
 Gln Leu Glu Phe Asn Asp Lys Lys Gly Ala Lys Ile Ile Lys Glu Val
     100                 105                 110

 ctc tta gaa gca caa gat atg gca gtg aga gac cat aac gtg gaa ttc      440
 Leu Leu Glu Ala Gln Asp Met Ala Val Arg Asp His Asn Val Glu Phe
 115                 120                 125                 130

 agg tcc aat tta tat ata gct gag tcc acc tca gga cga ggc cag tgc      488
 Arg Ser Asn Leu Tyr Ile Ala Glu Ser Thr Ser Gly Arg Gly Gln Cys
                 135                 140                 145

 ctg aac acc atc cgc tac cat ggc aga ggt cgc ttt ggg atc atg gag      536
 Leu Asn Thr Ile Arg Tyr His Gly Arg Gly Arg Phe Gly Ile Met Glu
             150                 155                 160

 aag gtt tat tgc cat tat ttt gtg aag ttg gtg gaa ggg ccc cca cct      584
 Lys Val Tyr Cys His Tyr Phe Val Lys Leu Val Glu Gly Pro Pro Pro
         165                 170                 175

 cca cct gag cca cca aag acg gca gtt gcc cat gcc aaa gag tat att      632
 Pro Pro Glu Pro Pro Lys Thr Ala Val Ala His Ala Lys Glu Tyr Ile
     180                 185                 190

 cag cag ttc gca gcc gga cca tcg ttc aca ctc tat gat gag gag att      680
 Gln Gln Phe Ala Ala Gly Pro Ser Phe Thr Leu Tyr Asp Glu Glu Ile
 195                 200                 205                 210

 cag act cca cag tgt ata tat ttt gcc att tat ttt cta aaa ata aac      728
 Gln Thr Pro Gln Cys Ile Tyr Phe Ala Ile Tyr Phe Leu Lys Ile Asn
                 215                 220                 225

 aaa aat tga aggcaaaaaa aaaaaa                                        753
 Lys Asn 






      <210> 111
      <211> 2055
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (357)..(2015)

      <400> 111
 attgagttcg cagaccctag tccagtgtgg tggaattctg caaatcaggt ttctaaacat     60

 taacaaccgg agagaaatga cattttgggg ccgccggtga ctcttgcgtg cctctgctgc    120

 cccctggtgg cagccccgag tcacttccag cagggccccc caccccaagg gcccagcctc    180

 gggcaggaag ggtacaaagc ccccgccgtg gctctgccac gaggtctcct ggaaatgagg    240

 ggaacagcac agcgacgtcc ttgcgtccta aatgcatccc ctgatggccg tttttcgcca    300

 cacaggcttg gcaaaatctc tgcgtcactg agcagcattt taacctcttg aatgag        356                                                                 
 atg cct ccg acc ttt tgg atc ctc ttt ctg cac ctc tca ggg gac agg      404
 Met Pro Pro Thr Phe Trp Ile Leu Phe Leu His Leu Ser Gly Asp Arg
   1               5                  10                  15

 tcc cgt ctg tac ggc gct gcc tac gag aaa ccc aag ttc att act gca      452
 Ser Arg Leu Tyr Gly Ala Ala Tyr Glu Lys Pro Lys Phe Ile Thr Ala
              20                  25                  30

 gcc aaa gga aag gtg cag gcg gtg gga ggc tcc tgc aag gtg atg cgt      500
 Ala Lys Gly Lys Val Gln Ala Val Gly Gly Ser Cys Lys Val Met Arg
          35                  40                  45

 ctg gcc ata agt ccc act gcc ttc tcc cac ctg ctg gcc tgt gcc cag      548
 Leu Ala Ile Ser Pro Thr Ala Phe Ser His Leu Leu Ala Cys Ala Gln
      50                  55                  60

 cag ttc cgg aag cag acc cag gcc cag gtg tac agt gag gac atg gcc      596
 Gln Phe Arg Lys Gln Thr Gln Ala Gln Val Tyr Ser Glu Asp Met Ala
  65                  70                  75                  80

 ctg aac ata ggc tcg gaa cca gaa ggc ctg cag gtg gaa gag aag gag      644
 Leu Asn Ile Gly Ser Glu Pro Glu Gly Leu Gln Val Glu Glu Lys Glu
                  85                  90                  95

 cgc cct gtg cag agg ctc agt agc gtc ctg ggg ccc ctg gag gag ctt      692
 Arg Pro Val Gln Arg Leu Ser Ser Val Leu Gly Pro Leu Glu Glu Leu
             100                 105                 110

 ctg cag ccg cta ttc ccc ctg ctc agc ctc tcc aag gcc aga gtg cag      740
 Leu Gln Pro Leu Phe Pro Leu Leu Ser Leu Ser Lys Ala Arg Val Gln
         115                 120                 125

 aca cct gcg gtt gtt gcc gat tca ggg aag tcg aag ggc aaa gac aag      788
 Thr Pro Ala Val Val Ala Asp Ser Gly Lys Ser Lys Gly Lys Asp Lys
     130                 135                 140

 gag agg aaa acg tcc aca gga caa cac agc aca gtc cag cct gag gtt      836
 Glu Arg Lys Thr Ser Thr Gly Gln His Ser Thr Val Gln Pro Glu Val
 145                 150                 155                 160

 gcc gat aag ata gtc ctg gtc gca gac aga cat ctc ctg gag ctg cca      884
 Ala Asp Lys Ile Val Leu Val Ala Asp Arg His Leu Leu Glu Leu Pro
                 165                 170                 175

 ctg gaa ggt ctc tct gtg ttc gat gaa ggg aca att tcc tct gtg tca      932
 Leu Glu Gly Leu Ser Val Phe Asp Glu Gly Thr Ile Ser Ser Val Ser
             180                 185                 190

 cga gaa ttt tct ctt caa atg ctg tgg aat cgc ctc cat aaa gaa gag      980
 Arg Glu Phe Ser Leu Gln Met Leu Trp Asn Arg Leu His Lys Glu Glu
         195                 200                 205

 aca gaa ggt ggc gtg aaa aag gag gga aga agc aga gac ccc aaa aag     1028
 Thr Glu Gly Gly Val Lys Lys Glu Gly Arg Ser Arg Asp Pro Lys Lys
     210                 215                 220

 aga agc cta gcg aag aag ggc agg aag ggc agc atc ccc cgg acc atc     1076
 Arg Ser Leu Ala Lys Lys Gly Arg Lys Gly Ser Ile Pro Arg Thr Ile
 225                 230                 235                 240

 ccc cct gac tgc atc ata gtc gac tca gac aac ttc aag ttc gtc gtg     1124
 Pro Pro Asp Cys Ile Ile Val Asp Ser Asp Asn Phe Lys Phe Val Val
                 245                 250                 255

 gac cca tac gag gag gcc cag ggc cca gaa atg cta act cct gtc tcc     1172
 Asp Pro Tyr Glu Glu Ala Gln Gly Pro Glu Met Leu Thr Pro Val Ser
             260                 265                 270

 atc acc caa gac att ttg gaa aga ttc caa gac aca ttc acg tcg cga     1220
 Ile Thr Gln Asp Ile Leu Glu Arg Phe Gln Asp Thr Phe Thr Ser Arg
         275                 280                 285

 tgg gcg gga cat ctg gga agc aag cac ttt ccc agc cag gcc cag tgg     1268
 Trp Ala Gly His Leu Gly Ser Lys His Phe Pro Ser Gln Ala Gln Trp
     290                 295                 300

 gag cag gcc ctg ggc agc tgc agc ggt ttc ttc ttc tat gga atg gag     1316
 Glu Gln Ala Leu Gly Ser Cys Ser Gly Phe Phe Phe Tyr Gly Met Glu
 305                 310                 315                 320

 agc ttc ctg tcc cat ata tta gtg gag aga ttg gtc gcc atg aac ttg     1364
 Ser Phe Leu Ser His Ile Leu Val Glu Arg Leu Val Ala Met Asn Leu
                 325                 330                 335

 caa gag tgc cag gtg gca gtc ctg ctg gac ctg gca cgg tcc tac cag     1412
 Gln Glu Cys Gln Val Ala Val Leu Leu Asp Leu Ala Arg Ser Tyr Gln
             340                 345                 350

 agc ttg aag agg cac atg gag agc gtg gag cac agg aga tct gtt ggc     1460
 Ser Leu Lys Arg His Met Glu Ser Val Glu His Arg Arg Ser Val Gly
         355                 360                 365

 cgt tgg gaa gcc aat tgg aga aac ggt gcg tct cct tca gaa gat gag     1508
 Arg Trp Glu Ala Asn Trp Arg Asn Gly Ala Ser Pro Ser Glu Asp Glu
     370                 375                 380

 tgg cga cga ggc ggt gaa cca agg cga ggc ttc tca gac ctt gaa gga     1556
 Trp Arg Arg Gly Gly Glu Pro Arg Arg Gly Phe Ser Asp Leu Glu Gly
 385                 390                 395                 400

 caa gct gct gct gct cca aag ctc cga gct cct tcc cac cac gct caa     1604
 Gln Ala Ala Ala Ala Pro Lys Leu Arg Ala Pro Ser His His Ala Gln
                 405                 410                 415

 ctt ggt cct gta tgg gct gcc gca cca agc cat cgg gta gtg cag gcc     1652
 Leu Gly Pro Val Trp Ala Ala Ala Pro Ser His Arg Val Val Gln Ala
             420                 425                 430

 tgg acc tgc ctc cca tca gct gct ggg gcc cca gca ctt gcc tct gcc     1700
 Trp Thr Cys Leu Pro Ser Ala Ala Gly Ala Pro Ala Leu Ala Ser Ala
         435                 440                 445

 ctt ggc tct gcc cct ctg cca acc cat ccc cac ctc ccg gct ccc atc     1748
 Leu Gly Ser Ala Pro Leu Pro Thr His Pro His Leu Pro Ala Pro Ile
     450                 455                 460

 ccc agc tcc cag ctc gct ctc ccc ttc ctg ggc ctc tcc cca gcc ctt     1796
 Pro Ser Ser Gln Leu Ala Leu Pro Phe Leu Gly Leu Ser Pro Ala Leu
 465                 470                 475                 480

 ggt gca gcc tca gcc agg gac cct ccc cca gcg act tcc cgc aag gca     1844
 Gly Ala Ala Ser Ala Arg Asp Pro Pro Pro Ala Thr Ser Arg Lys Ala
                 485                 490                 495

 gcc gcc tgg acc tcg agc tct gcc tgc ctg tgt gcg cca tgg ggt ctg     1892
 Ala Ala Trp Thr Ser Ser Ser Ala Cys Leu Cys Ala Pro Trp Gly Leu
             500                 505                 510

 cgt cgg ggc tgg agc tgc gtc tct tcc cgg ggc cag gac aag ggc ggc     1940
 Arg Arg Gly Trp Ser Cys Val Ser Ser Arg Gly Gln Asp Lys Gly Gly
         515                 520                 525

 ctc ccc ttg gcg gcg ctg gtg ctg agt tgc tta gac cag aag act att     1988
 Leu Pro Leu Ala Ala Leu Val Leu Ser Cys Leu Asp Gln Lys Thr Ile
     530                 535                 540

 cag acc gtg agc ctg ttt ttg att tga gtgtt ccactaaaca aacaacaaaa     2040
 Gln Thr Val Ser Leu Phe Leu Ile 
 545                 550

 gccaaaaaaa aaaaa                                                    2055




      <210> 112
      <211> 1151
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (118)..(702)

      <400> 112
 gttccagata atccctttcc cagtcctgcc tgacatctgg gtagggggtt tgtccctgga     60

 attctgggac actggctggg gtttgaggag agaagccagt acctacctgg ctgcagg       117                                                                 
 atg aag ctg gcc agt ggc ttc ttg gtt ttg tgg ctc agc ctt ggg ggt      165
 Met Lys Leu Ala Ser Gly Phe Leu Val Leu Trp Leu Ser Leu Gly Gly
   1               5                  10                  15

 ggc ctg gct cag agc gac acg agc cct gac acg gag gag tcc tat tca      213
 Gly Leu Ala Gln Ser Asp Thr Ser Pro Asp Thr Glu Glu Ser Tyr Ser
              20                  25                  30

 gac tgg ggc ctt cgg cac ctc cgg gga agc ttt gaa tcc gtc aat agc      261
 Asp Trp Gly Leu Arg His Leu Arg Gly Ser Phe Glu Ser Val Asn Ser
          35                  40                  45

 tac ttc gat tct ttt ctg gag ctg ctg gga ggg aag aat gga gtc tgt      309
 Tyr Phe Asp Ser Phe Leu Glu Leu Leu Gly Gly Lys Asn Gly Val Cys
      50                  55                  60

 cag tac agg tgc cga tat gga aag gca cca atg ccc aga cct ggc tac      357
 Gln Tyr Arg Cys Arg Tyr Gly Lys Ala Pro Met Pro Arg Pro Gly Tyr
  65                  70                  75                  80

 aag ccc caa gag ccc aat ggc tgc ggc tcc tat ttc ctg ggt ctc aag      405
 Lys Pro Gln Glu Pro Asn Gly Cys Gly Ser Tyr Phe Leu Gly Leu Lys
                  85                  90                  95

 gta cca gaa agt atg gac ttg ggc att cca gca atg aca aag tgc tgc      453
 Val Pro Glu Ser Met Asp Leu Gly Ile Pro Ala Met Thr Lys Cys Cys
             100                 105                 110

 aac cag ctg gat gtc tgt tat gac act tgc ggt gcc aac aaa tat cgc      501
 Asn Gln Leu Asp Val Cys Tyr Asp Thr Cys Gly Ala Asn Lys Tyr Arg
         115                 120                 125

 tgt gat gca aaa ttc cga tgg tgt ctc cac tcg atc tgc tct gac ctt      549
 Cys Asp Ala Lys Phe Arg Trp Cys Leu His Ser Ile Cys Ser Asp Leu
     130                 135                 140

 aag cgg agt ctg ggc ttt gtc tcc aaa gtg gaa gcc tgt gat tcc ctg      597
 Lys Arg Ser Leu Gly Phe Val Ser Lys Val Glu Ala Cys Asp Ser Leu
 145                 150                 155                 160

 gtt gac act gtg ttc aac acc gtg tgg acc ttg ggc tgc cgc ccc ttt      645
 Val Asp Thr Val Phe Asn Thr Val Trp Thr Leu Gly Cys Arg Pro Phe
                 165                 170                 175

 atg aat agt cag cgg gca gct tgc atc tgt gca gag gag gag aag gaa      693
 Met Asn Ser Gln Arg Ala Ala Cys Ile Cys Ala Glu Glu Glu Lys Glu
             180                 185                 190

 gag tta tga ggaagaa gtgattcctt cctggttttg agtgacacca cagctgtcag      749
 Glu Leu 


 ccttcaagat gtcaagtctt cgagtcagcg tgactcattc gttcttccaa cagtttggac    809

 accacaaagc aggagaaagg gaacattttt ctacagctgg aaagtgagtc ctatcctttg    869

 aggaaatttg aaaaaagaca tggagtggtt tgaaagctac tcttcattta agactgctct    929

 ccccaaccaa gacacatttg cctggaaatt cagttcttag cttaaagact aaaatgcaag    989

 caaaccctgc aattcctgga cctgatagtt atattcatga gtgaaattgt ggggagtcca   1049

 gccatttggg aggcaatgac tttctgctgg cccatgtttc agttgccagt aagcttctca   1109

 catttaataa agtgtacttt ttagaacatt aaaaaaaaaa aa                      1151




      <210> 113
      <211> 1475
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (58)..(1371)

      <400> 113
 gtgacagcac gctcctttga agaggaagga gagcatttgg gcagtagaaa acacaga        57                                                                 
 atg tcc gaa gaa aaa gac tgt ggt ggc gga gat gct ctc tcc aat ggc      105
 Met Ser Glu Glu Lys Asp Cys Gly Gly Gly Asp Ala Leu Ser Asn Gly
   1               5                  10                  15

 atc aag aaa cac aga aca agt ttg cct tct cct atg ttt tcc aga aat      153
 Ile Lys Lys His Arg Thr Ser Leu Pro Ser Pro Met Phe Ser Arg Asn
              20                  25                  30

 gac ttc agt atc tgg agc atc ctc aga aaa tgt att gga atg gaa cta      201
 Asp Phe Ser Ile Trp Ser Ile Leu Arg Lys Cys Ile Gly Met Glu Leu
          35                  40                  45

 tcc aag atc acg atg cca gtt ata ttt aat gag cct ctg agc ttc cta      249
 Ser Lys Ile Thr Met Pro Val Ile Phe Asn Glu Pro Leu Ser Phe Leu
      50                  55                  60

 cag cgc cta act gaa tac atg gag cat act tac ctc atc cac aag gcc      297
 Gln Arg Leu Thr Glu Tyr Met Glu His Thr Tyr Leu Ile His Lys Ala
  65                  70                  75                  80

 agt tca ctc tct gat cct gtg gaa agg atg cag tgt gta gct gcg ttt      345
 Ser Ser Leu Ser Asp Pro Val Glu Arg Met Gln Cys Val Ala Ala Phe
                  85                  90                  95

 gct gta tct gct gtt gct tct cag tgg gaa cgg act gga aaa cct ttc      393
 Ala Val Ser Ala Val Ala Ser Gln Trp Glu Arg Thr Gly Lys Pro Phe
             100                 105                 110

 aac cca ctg ctg gga gag act tat gaa tta gtg cga gat gac ctt gga      441
 Asn Pro Leu Leu Gly Glu Thr Tyr Glu Leu Val Arg Asp Asp Leu Gly
         115                 120                 125

 ttt aga ctc atc tcc gaa cag gtc agc cat cac cca cca atc agt gca      489
 Phe Arg Leu Ile Ser Glu Gln Val Ser His His Pro Pro Ile Ser Ala
     130                 135                 140

 ttt cat gct gaa gga tta aac aat gac ttc atc ttt cat ggc tct atc      537
 Phe His Ala Glu Gly Leu Asn Asn Asp Phe Ile Phe His Gly Ser Ile
 145                 150                 155                 160

 tat ccc aaa ctg aaa ttc tgg ggg aag agt gta gaa gca gaa ccc aaa      585
 Tyr Pro Lys Leu Lys Phe Trp Gly Lys Ser Val Glu Ala Glu Pro Lys
                 165                 170                 175

 gga acc atc acc ttg gag ctc ctt gaa cac aat gag gca tat aca tgg      633
 Gly Thr Ile Thr Leu Glu Leu Leu Glu His Asn Glu Ala Tyr Thr Trp
             180                 185                 190

 aca aat ccc acc tgc tgt gtg cat aat atc att gtg ggt aaa ctg tgg      681
 Thr Asn Pro Thr Cys Cys Val His Asn Ile Ile Val Gly Lys Leu Trp
         195                 200                 205

 atc gaa cag tat ggc aat gtg gaa att ata aac cac aag act ggg gac      729
 Ile Glu Gln Tyr Gly Asn Val Glu Ile Ile Asn His Lys Thr Gly Asp
     210                 215                 220

 aaa tgt gtg ttg aat ttt aag cca tgt ggc ctt ttt ggt aag gaa tta      777
 Lys Cys Val Leu Asn Phe Lys Pro Cys Gly Leu Phe Gly Lys Glu Leu
 225                 230                 235                 240

 cac aaa gtt gaa ggc tac att caa gat aaa agc aaa aag aag ctc tgt      825
 His Lys Val Glu Gly Tyr Ile Gln Asp Lys Ser Lys Lys Lys Leu Cys
                 245                 250                 255

 gcc ctc tat ggg aag tgg act gaa tgt tta tac agt gtt gac cct gcc      873
 Ala Leu Tyr Gly Lys Trp Thr Glu Cys Leu Tyr Ser Val Asp Pro Ala
             260                 265                 270

 acg ttt gac gct tac aaa aaa aat gat aag aaa aat aca gaa gag aag      921
 Thr Phe Asp Ala Tyr Lys Lys Asn Asp Lys Lys Asn Thr Glu Glu Lys
         275                 280                 285

 aag aac agc aaa cag atg agc acc tct gag gag ttg gat gaa atg cca      969
 Lys Asn Ser Lys Gln Met Ser Thr Ser Glu Glu Leu Asp Glu Met Pro
     290                 295                 300

 gtg ccg gat tct gaa agt gta ttc att atc cct gga agc gtt ctt cta     1017
 Val Pro Asp Ser Glu Ser Val Phe Ile Ile Pro Gly Ser Val Leu Leu
 305                 310                 315                 320

 tgg cga ata gcc cca cgg cct cca aat tct gcc cag atg tat aat ttt     1065
 Trp Arg Ile Ala Pro Arg Pro Pro Asn Ser Ala Gln Met Tyr Asn Phe
                 325                 330                 335

 act agt ttt gca atg gtt ttg aat gaa gta gac aaa gac atg gag agt     1113
 Thr Ser Phe Ala Met Val Leu Asn Glu Val Asp Lys Asp Met Glu Ser
             340                 345                 350

 gtg att ccc aag aca gac tgc agg tta cgg cct gac atc aga gcc atg     1161
 Val Ile Pro Lys Thr Asp Cys Arg Leu Arg Pro Asp Ile Arg Ala Met
         355                 360                 365

 gaa aat gga gag ata gat caa gct agt gaa gaa aaa aaa cga ctt gag     1209
 Glu Asn Gly Glu Ile Asp Gln Ala Ser Glu Glu Lys Lys Arg Leu Glu
     370                 375                 380

 gaa aaa caa aga gca gcc cgc aaa aac agg tcc aag tca gaa gag gac     1257
 Glu Lys Gln Arg Ala Ala Arg Lys Asn Arg Ser Lys Ser Glu Glu Asp
 385                 390                 395                 400

 tgg aag acg agg tgg ttc cat caa ggt cct aat ccc tac aat gga gca     1305
 Trp Lys Thr Arg Trp Phe His Gln Gly Pro Asn Pro Tyr Asn Gly Ala
                 405                 410                 415

 cag gac tgg att tac tct ggc agc tac tgg gac aga aat tac ttc aat     1353
 Gln Asp Trp Ile Tyr Ser Gly Ser Tyr Trp Asp Arg Asn Tyr Phe Asn
             420                 425                 430

 ttg cct gac att tat taa aatgca tacaagtcag ggtgtttggc taatctacaa     1407
 Leu Pro Asp Ile Tyr 
         435

 ataagtctta aacctatgtt tttaaatttt tttcccttgg tttctactta tcttttaaaa   1467

 aaaaaaaa                                                            1475




      <210> 114
      <211> 907
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (359)..(733)

      <400> 114
 atctttatta tactttataa atgagatttc atttatataa atcaggaagc taaactaaaa     60

 tagaaacact agatttaaat tctgatttga atactctgat caaaataaca aatctcacac    120

 tgggaaacca tctatcagca agcagagagc tactgtgtgt ccttccttag aagagtttga    180

 acaccgagaa cccacagcat atttgcagta cagtaacagc aattcctttg tcattatcac    240

 agaactttaa ttttcatata ctttgctggg accaaccaaa ccatcccata tatataacca    300

 tatccatata tatatatata tatatcccac atatatatgg gatggtatat atatacac      358                                                                 
 atg tat atg tat gtg tgt gtg tat ata tgt gta tat atg tat aca cac      406
 Met Tyr Met Tyr Val Cys Val Tyr Ile Cys Val Tyr Met Tyr Thr His
   1               5                  10                  15

 aca cac aca cac ata tat ata tat ata cac aca cac aca cat ata tat      454
 Thr His Thr His Ile Tyr Ile Tyr Ile His Thr His Thr His Ile Tyr
              20                  25                  30

 atg gag aga gag aga gag aca gtg tct tgc tct gtc gcc cag gct gga      502
 Met Glu Arg Glu Arg Glu Thr Val Ser Cys Ser Val Ala Gln Ala Gly
          35                  40                  45

 gtg cag tgg tac gat ctt ggc tca ttg caa cct ccg cct ccc agg ctc      550
 Val Gln Trp Tyr Asp Leu Gly Ser Leu Gln Pro Pro Pro Pro Arg Leu
      50                  55                  60

 aag cga ttc tca tgt ctc agt ctc cca agt agc tgg gat tac agg tgt      598
 Lys Arg Phe Ser Cys Leu Ser Leu Pro Ser Ser Trp Asp Tyr Arg Cys
  65                  70                  75                  80

 gca cca cca cac cag gct aac cat tcc ata cat ttt ata caa tca ttt      646
 Ala Pro Pro His Gln Ala Asn His Ser Ile His Phe Ile Gln Ser Phe
                  85                  90                  95

 tta aaa aga agc atg aac cat ttc ggt ttt aga gaa tta agt ttt ttt      694
 Leu Lys Arg Ser Met Asn His Phe Gly Phe Arg Glu Leu Ser Phe Phe
             100                 105                 110

 aaa aaa gag act ctt aaa aaa aag tca tta tat gaa taa aatctgcttt       743
 Lys Lys Glu Thr Leu Lys Lys Lys Ser Leu Tyr Glu 
         115                 120

 gtgttaattc cgacaaatca ttccatcatt gagtctgtca ccaatttttt ttttttgaaa    803

 tggagtttcg ctcttgttgc ccaggctgga gtgcaatggt acgatctcgg cctcgtgccg    863

 aatttcttgc tcgagggcaa aattccctat agtgagtcga ttga                     907




      <210> 115
      <211> 940
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (67)..(609)

      <400> 115
 ctggactcag ggcggtttga aagatcggcg cgcaccgcag gagcaacggt tggtcctgcg     60

 gctgtg   atg tcg gtg ttg agg ccc ctg gac aag ctg ccc ggc ctg aac     108
          Met Ser Val Leu Arg Pro Leu Asp Lys Leu Pro Gly Leu Asn
            1               5                  10

 acg gcc acc atc ttg ctg gtg ggc acg gag gat gct ctt ctg cag cag      156
 Thr Ala Thr Ile Leu Leu Val Gly Thr Glu Asp Ala Leu Leu Gln Gln
  15                  20                  25                  30

 ctg gcg gac tcg atg ctc aaa gag gac tgc gcc tcc gag ctg aag gtc      204
 Leu Ala Asp Ser Met Leu Lys Glu Asp Cys Ala Ser Glu Leu Lys Val
                  35                  40                  45

 cac ttg gca aag tcc ctc cct ttg ccc tcc agt gtg aat cgg ccc cga      252
 His Leu Ala Lys Ser Leu Pro Leu Pro Ser Ser Val Asn Arg Pro Arg
              50                  55                  60

 att gac ctg atc gtg ttt gtg gtt aat ctt cac agc aaa tac agt ctc      300
 Ile Asp Leu Ile Val Phe Val Val Asn Leu His Ser Lys Tyr Ser Leu
          65                  70                  75

 cag aac aca gag gag tcc ctg cgc cat gtg gat gcc agc ttc ttc ttg      348
 Gln Asn Thr Glu Glu Ser Leu Arg His Val Asp Ala Ser Phe Phe Leu
      80                  85                  90

 ggg aag gtg tgt ttc ctc gcc aca ggt gct ggg cgg gag agc cac tgc      396
 Gly Lys Val Cys Phe Leu Ala Thr Gly Ala Gly Arg Glu Ser His Cys
  95                 100                 105                 110

 agc att cac cgg cac acc gtg gtg aag ctg gcc cac acc tat caa agc      444
 Ser Ile His Arg His Thr Val Val Lys Leu Ala His Thr Tyr Gln Ser
                 115                 120                 125

 ccc ctg ctc tac tgt gac ctg gag gtg gaa ggc ttt agg gcc acc atg      492
 Pro Leu Leu Tyr Cys Asp Leu Glu Val Glu Gly Phe Arg Ala Thr Met
             130                 135                 140

 gcg cag cgc ctg gtg cgc gtg ctg cag atc tgt gct ggc cac gtg ccc      540
 Ala Gln Arg Leu Val Arg Val Leu Gln Ile Cys Ala Gly His Val Pro
         145                 150                 155

 ggt gtc tca gct ctg aac ctg ctg tcc ctg ctg aga agc tct gag ggc      588
 Gly Val Ser Ala Leu Asn Leu Leu Ser Leu Leu Arg Ser Ser Glu Gly
     160                 165                 170

 ccc tcc ctg gag gac ctg tga gg gtggctggcc cctgggctgc cccttctcat      641
 Pro Ser Leu Glu Asp Leu 
 175                 180

 ggcttcgtgc tgactccata aacattctct gttgaggatg tccagtcagg gcttgacagg    701

 cccaggctca gccccccgtg gctgggaagg ttccctgcag tgccagtgct gcagcaggga    761

 gagctgggca gaagcagcga gggggcccag ctggcgagac tgtagccccc tcccactccc    821

 acactcactc ttgcagagcc tgtgtcttta agcagctggc gtgttacatc tccatttaag    881

 gtttcctttg aacaaaaggt ctgtggctaa aaaaagttta aaaatcaaaa aaaaaaaaa     940




      <210> 116
      <211> 919
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (79)..(588)

      <400> 116
 tactactact aaattcgcgg ccgcgtcgac tttttttttt tttttaaaca tttgaagagg     60

 tatggggcgg agggggaa  atg gaa ttt gac cga ctc act att gcc cag act     111
                      Met Glu Phe Asp Arg Leu Thr Ile Ala Gln Thr
                        1               5                  10

 gga gtg cag tgg cta ttc ata agc aca atc ata gct cac tgc agc ctt      159
 Gly Val Gln Trp Leu Phe Ile Ser Thr Ile Ile Ala His Cys Ser Leu
              15                  20                  25

 gaa ctc ctg ggc tca agc aat cct cct acc tca gct tcc caa gta gct      207
 Glu Leu Leu Gly Ser Ser Asn Pro Pro Thr Ser Ala Ser Gln Val Ala
          30                  35                  40

 ggg act aca ggc gtg tgc cac agt ggc cag cta att ttt tca ttt tta      255
 Gly Thr Thr Gly Val Cys His Ser Gly Gln Leu Ile Phe Ser Phe Leu
      45                  50                  55

 aaa gat gac atc tta cta tat tgc cca tct agt cac aaa ctc cta gcc      303
 Lys Asp Asp Ile Leu Leu Tyr Cys Pro Ser Ser His Lys Leu Leu Ala
  60                  65                  70                  75

 tca agc aat cct ctt gcc tca gcc tca caa gta gct agg att aca ggc      351
 Ser Ser Asn Pro Leu Ala Ser Ala Ser Gln Val Ala Arg Ile Thr Gly
                  80                  85                  90

 gca ggc cat cat gac caa caa aaa gaa att ttt tat att gat tgc atg      399
 Ala Gly His His Asp Gln Gln Lys Glu Ile Phe Tyr Ile Asp Cys Met
              95                 100                 105

 atg aaa tat ttt gaa tat att gag tta aat aga ttt tct cat ttg ttt      447
 Met Lys Tyr Phe Glu Tyr Ile Glu Leu Asn Arg Phe Ser His Leu Phe
         110                 115                 120

 att tgt gct gtt ttc ttt tta atg tgg cta tta gaa aat tta caa tta      495
 Ile Cys Ala Val Phe Phe Leu Met Trp Leu Leu Glu Asn Leu Gln Leu
     125                 130                 135

 act ata tgg gtc aca ttt gtg acc tcc att gta ttt cta ttg ggc aat      543
 Thr Ile Trp Val Thr Phe Val Thr Ser Ile Val Phe Leu Leu Gly Asn
 140                 145                 150                 155

 gct gtg cta gac tca cca gaa cgt ata cat att ttt att ttt tag act      591
 Ala Val Leu Asp Ser Pro Glu Arg Ile His Ile Phe Ile Phe 
                 160                 165

 gatgtataca gggcccctgt atacatgtgt atttctaccg ccagtaactg aatacttctt    651

 taagaaggag aaatccttaa aaaatctggc tttaggcctg acccataaag cctgaaacag    711

 ctctaaattg gatggcatac ctataatgaa aagccatatt ttataagtcc ttgcaatttt    771

 aaaagcgtta aatcccttgg taaaataaaa attacctgga gaattatggc cctaaactct    831

 agtccaacta gaatgccatg ccaattttgg agaccggaga aactttcctt tttttgctac    891

 aattggcttt ttcaaaggaa aaaagaaa                                       919




      <210> 117
      <211> 1114
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (352)..(882)

      <400> 117
 gtccgtggct gtcagcttgg gtgtcctggc tcggcttagg ggcacaggct tgcgggcgga     60

 cctagggacg gcggaggcat cgtgtccttc ctgcaggaag gaaggagctt ccggagcttt    120

 cctgggaggc tcactggggc cgcggagata acctgaggtc ctgcaacagg ctgggggccc    180

 aaggaccatc ccaggccttg gaacagttgg tatctttcag tcgccgccct ggagaggcag    240

 gtgtttgact tcctgggcta ccagtgggcg cccatcctgg ccaactttgt ccacatcatc    300

 atcgtcatcc tgggactctt cggcaccatc cagtaccggc tgcgctacgt c atg gtg     357
                                                          Met Val
                                                            1

 tac acg ctg tgg gca gcc gtc tgg gtc acc tgg aac gtc ttc atc atc      405
 Tyr Thr Leu Trp Ala Ala Val Trp Val Thr Trp Asn Val Phe Ile Ile
           5                  10                  15

 tgc ttc tac ctg gaa gtc ggt ggc ctc tta aag gac agc gag cta ctg      453
 Cys Phe Tyr Leu Glu Val Gly Gly Leu Leu Lys Asp Ser Glu Leu Leu
      20                  25                  30

 acc ttc agc ctc tcc cgg cat cgc tcc tgg tgg cgt gag cgc tgg cca      501
 Thr Phe Ser Leu Ser Arg His Arg Ser Trp Trp Arg Glu Arg Trp Pro
  35                  40                  45                  50

 ggc tgt ctg cat gag gag gtg cca gca gtg ggc ctc ggg gcc ccc cat      549
 Gly Cys Leu His Glu Glu Val Pro Ala Val Gly Leu Gly Ala Pro His
                  55                  60                  65

 ggc cag gac ctg gtg tca ggt gct ggc tgt gcc ctg gag ccc agc tat      597
 Gly Gln Asp Leu Val Ser Gly Ala Gly Cys Ala Leu Glu Pro Ser Tyr
              70                  75                  80

 gtg gag gcc cta cac agt tgc ctg cag atc ctg atc gcg gct caa aac      645
 Val Glu Ala Leu His Ser Cys Leu Gln Ile Leu Ile Ala Ala Gln Asn
          85                  90                  95

 cag aat ccc aga tgg ctt gct cca cag agg agg agg aac ccc tgg tgg      693
 Gln Asn Pro Arg Trp Leu Ala Pro Gln Arg Arg Arg Asn Pro Trp Trp
     100                 105                 110

 ctg ctg gct gga gtg ggc tgg ggc caa agc ttc tgg gct ttg tct gtg      741
 Leu Leu Ala Gly Val Gly Trp Gly Gln Ser Phe Trp Ala Leu Ser Val
 115                 120                 125                 130

 gct gcc agg tgg tca gcg tgt tta cgg agg aag agg aca gct ttg att      789
 Ala Ala Arg Trp Ser Ala Cys Leu Arg Arg Lys Arg Thr Ala Leu Ile
                 135                 140                 145

 tca ttg gtg gat ttg atc cat ttc ctc tct acc atg tca atg aaa agc      837
 Ser Leu Val Asp Leu Ile His Phe Leu Ser Thr Met Ser Met Lys Ser
             150                 155                 160

 cat cca gtc tct tgt cca agc agg tgt act tgc ctg cgt aag tga gga      885
 His Pro Val Ser Cys Pro Ser Arg Cys Thr Cys Leu Arg Lys 
         165                 170                 175

 aacagctgat cctgctcctg tggcctccag cctcagcgac cgaccagtga caatgacagg    945

 agctcccagg ccttgggacg cgcccccacc cagcaccccc caggcggccg gcagcacctg   1005

 ccctgggttc taagtactgg acaccagcca gggcggcagg gcagtgccac ggctggctgc   1065

 agcgtcaaga gagtttgtaa tttcctctct cttaaaaaaa aaaaaaaaa               1114




      <210> 118
      <211> 1510
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (56)..(538)

      <400> 118
 tgaaaaacag ggatgtagtt cagcagtgtc tgaataaggc tgatgactca gaatc atg      58
                                                              Met
                                                                1

 cag tgc ctg gct tct cag gcc gcc gcc agc cgg gac tgc ttt agg cgc      106
 Gln Cys Leu Ala Ser Gln Ala Ala Ala Ser Arg Asp Cys Phe Arg Arg
               5                  10                  15

 gaa ccc acg ctt ctg acc tgt gct ctg tct ttg cag ttc tgc acg gag      154
 Glu Pro Thr Leu Leu Thr Cys Ala Leu Ser Leu Gln Phe Cys Thr Glu
          20                  25                  30

 cta aac cag ccg acc ctg ccc aac atc cgc aag tgg aag ggg ccc cgg      202
 Leu Asn Gln Pro Thr Leu Pro Asn Ile Arg Lys Trp Lys Gly Pro Arg
      35                  40                  45

 gga tgc tgg aag gct gtt gtt gct gag aag ccc tcg aat cag ctc cag      250
 Gly Cys Trp Lys Ala Val Val Ala Glu Lys Pro Ser Asn Gln Leu Gln
  50                  55                  60                  65

 aag gta ccc tcg tct gca aag cct ggc ctt tcc ctt cat tta att tat      298
 Lys Val Pro Ser Ser Ala Lys Pro Gly Leu Ser Leu His Leu Ile Tyr
                  70                  75                  80

 aca tac ttt tcc cct aat caa ggg cat tta aaa att tcc ttt gcc aat      346
 Thr Tyr Phe Ser Pro Asn Gln Gly His Leu Lys Ile Ser Phe Ala Asn
              85                  90                  95

 atc ccc ggt tca att ttg tat ttc tgc cca att ttt aaa tcc ttg cca      394
 Ile Pro Gly Ser Ile Leu Tyr Phe Cys Pro Ile Phe Lys Ser Leu Pro
         100                 105                 110

 ttc att tcc aaa tgc cct ggt ttt cgg ttc acg ttt aga ttg gta atg      442
 Phe Ile Ser Lys Cys Pro Gly Phe Arg Phe Thr Phe Arg Leu Val Met
     115                 120                 125

 gac tcc tgc caa gaa gga aat gag agc ctt agg gtg ttg gga gga gag      490
 Asp Ser Cys Gln Glu Gly Asn Glu Ser Leu Arg Val Leu Gly Gly Glu
 130                 135                 140                 145

 gag ggg aga aag gca aca aat ggg tat ttc tgt cct ttg tcc ttc taa      538
 Glu Gly Arg Lys Ala Thr Asn Gly Tyr Phe Cys Pro Leu Ser Phe 
                 150                 155                 160

 tcccttcgcc acagttctgt cttctgccaa gtttgtgcag agctcattac tcgttgactg    598

 aaaatttcag attcacctta gttcacacat gaagtatttg cttctagtgg tagaaattat    658

 gcacataatt tcagcataga aatgttctat tgaaatgttc agcagatttt ggttttgaat    718

 tttctttcat cagtatcacc catatgagca ggtaagggta aatctctgta aatacacgtt    778

 ttccctcata ttattattca aggccagatt tattcacctt gcaatgctta acatcaatgg    838

 agttttagat ttttaaacag actcctgata ataaccagga gttgaaaatg tattattaca    898

 taattttcct ataaatgcag atttttaaat ccctagtata cctaacatgc ttacaaacac    958

 atgtgattta tacttaatat gattatgttt ataatgtagg ctcttaaatc ataaatgtat   1018

 actggattaa aagtggccat ttttttgaca gtaagcccct actctctttt tagctactac   1078

 ttaaagaggt acatgtaaat cttctgtctc tgggttttat gtttgggggt gtaaatggct   1138

 cctgccagct gacagtgagt cagcacactt cagagaaggc tggagataaa gctgaatttg   1198

 aatgcatcta gttcagggtt ctcccttcca gtccacgtgg aaataataag aataatacca   1258

 ccttcctttt ttgatcgcac tttacatgta tgtaggtgtc tgagcttcac aagcctttta   1318

 tagtccattc agcactgcat tcattcaaca aatcattaat gaaaggtggc tatgtaccag   1378

 gcatattgtt tcatgccagg tacacactgg tgagaaaaac tccatgcctg catgttttca   1438

 ctctttgcaa gacacagtgg ggatcccggc tggagcctga cctggcccct cccgcaggga   1498

 gtgcacagcc cg                                                       1510




      <210> 119
      <211> 1778
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (505)..(1644)

      <400> 119
 tcccgggtcg acgatttcgt ggttcgagtt agagcacccg cgcggggaga gtgggttcga     60

 gcagaacccc ctctggacgg gcaaggaacc ctttcaggaa ccccatgacg gccgcggcgc    120

 cggcagcagt aggacaggcc gcgccgtacg cccgagaact gaggagtggg accaggggcg    180

 gggactgatg ttgcgtatac gaggagcgag ctgacgactg gcgtggtgcc tccgcccccc    240

 tttcttgttg catggcaaca acaaacactt gctcctgcgg accagatccc cggaggagtt    300

 gttgctgggc ggagtcagag cagttcttga ggttcaagga ggcgggggag acctgagctc    360

 acgcttgctg agacagaagt cacagcagga ttatgcccct cagggcaaga ggaagagttc    420

 agaaactgcc gccgtaaccc aagaacaaag ttgcatgcag agccaaccta agagcttcaa    480

 aatcgggatt ccttactgag aaag   atg tat aac ata aaa cag tca aca gat     531
                              Met Tyr Asn Ile Lys Gln Ser Thr Asp
                                1               5

 acc aag gaa gca gca gcc atc gag gct aga aga aat cga gaa aaa gag      579
 Thr Lys Glu Ala Ala Ala Ile Glu Ala Arg Arg Asn Arg Glu Lys Glu
  10                  15                  20                  25

 cga caa aac cga ttc ttc aat gtg cgg aac cga gtc atg ggg gtg gat      627
 Arg Gln Asn Arg Phe Phe Asn Val Arg Asn Arg Val Met Gly Val Asp
                  30                  35                  40

 gtc cag gcc ctg aac aac cag gtg gga gac cga aag cgt cgg gaa gca      675
 Val Gln Ala Leu Asn Asn Gln Val Gly Asp Arg Lys Arg Arg Glu Ala
              45                  50                  55

 gca gaa aga agc aag gag gca gct tat ggt acc agc cag gtg cag tat      723
 Ala Glu Arg Ser Lys Glu Ala Ala Tyr Gly Thr Ser Gln Val Gln Tyr
          60                  65                  70

 gat gtg gta gtc cag atg tta gag aag gaa gag gca gat cga aca cgt      771
 Asp Val Val Val Gln Met Leu Glu Lys Glu Glu Ala Asp Arg Thr Arg
      75                  80                  85

 cag ctg gcc aag aaa gtc cag gag ttt cgg gag cag aag cag cag ctc      819
 Gln Leu Ala Lys Lys Val Gln Glu Phe Arg Glu Gln Lys Gln Gln Leu
  90                  95                 100                 105

 aag aac ggg cgt gaa ttt agt ctt tgg gat cca ggc caa gtc tgg aag      867
 Lys Asn Gly Arg Glu Phe Ser Leu Trp Asp Pro Gly Gln Val Trp Lys
                 110                 115                 120

 ggg ctt cca acc tat ctt agt tac agt aat acc tat cct ggt cca gcc      915
 Gly Leu Pro Thr Tyr Leu Ser Tyr Ser Asn Thr Tyr Pro Gly Pro Ala
             125                 130                 135

 agc ctg cag tac ttc tct ggg gaa gac cta gac agg gac aca cgg ctg      963
 Ser Leu Gln Tyr Phe Ser Gly Glu Asp Leu Asp Arg Asp Thr Arg Leu
         140                 145                 150

 aga atg cag cag ggg cag ttc agg tac aac ttg gaa agg caa cag cag     1011
 Arg Met Gln Gln Gly Gln Phe Arg Tyr Asn Leu Glu Arg Gln Gln Gln
     155                 160                 165

 gag caa cag caa gcc aag gtt gat gag aat tat aca gat gcg ctc agt     1059
 Glu Gln Gln Gln Ala Lys Val Asp Glu Asn Tyr Thr Asp Ala Leu Ser
 170                 175                 180                 185

 aac cag ctg cgc ctc gcc atg gat gca cag gcc acc cat ctg gcc agg     1107
 Asn Gln Leu Arg Leu Ala Met Asp Ala Gln Ala Thr His Leu Ala Arg
                 190                 195                 200

 ctg gag gag tcc tgt cgt gcg gcc atg atg tgt gcc atg gcc aac gcc     1155
 Leu Glu Glu Ser Cys Arg Ala Ala Met Met Cys Ala Met Ala Asn Ala
             205                 210                 215

 aac aaa gcg cag gca gct gtg cag gct ggg cgt cag cgc tgt gag cgt     1203
 Asn Lys Ala Gln Ala Ala Val Gln Ala Gly Arg Gln Arg Cys Glu Arg
         220                 225                 230

 cag cgt gaa cag aag gcc aac ctt gcg gag atc cag cac cag agc acg     1251
 Gln Arg Glu Gln Lys Ala Asn Leu Ala Glu Ile Gln His Gln Ser Thr
     235                 240                 245

 agt gac cta ctg act gaa aac ccc cag gtc gcc caa cac cct atg gct     1299
 Ser Asp Leu Leu Thr Glu Asn Pro Gln Val Ala Gln His Pro Met Ala
 250                 255                 260                 265

 ccc tac cgg gtc ctg ccc tat tgc tgg aag ggc atg act cca gag cag     1347
 Pro Tyr Arg Val Leu Pro Tyr Cys Trp Lys Gly Met Thr Pro Glu Gln
                 270                 275                 280

 caa gct gcc atc agg aaa gag cag gaa gta caa cgc tct aag aag caa     1395
 Gln Ala Ala Ile Arg Lys Glu Gln Glu Val Gln Arg Ser Lys Lys Gln
             285                 290                 295

 gca cac cgt cag gct gag aaa aca ctg gat act gaa tgg aaa agc cag     1443
 Ala His Arg Gln Ala Glu Lys Thr Leu Asp Thr Glu Trp Lys Ser Gln
         300                 305                 310

 act atg agc tca gcc cag gca gtg ctg gag cta gaa gag cag gag agg     1491
 Thr Met Ser Ser Ala Gln Ala Val Leu Glu Leu Glu Glu Gln Glu Arg
     315                 320                 325

 gaa ttg tgt gct gta ttt caa agg ggt cta gga tcc ttc aac cag cag     1539
 Glu Leu Cys Ala Val Phe Gln Arg Gly Leu Gly Ser Phe Asn Gln Gln
 330                 335                 340                 345

 ctg gct aat gag caa aaa gcc cag cag gat tac ctg aat tca gta atc     1587
 Leu Ala Asn Glu Gln Lys Ala Gln Gln Asp Tyr Leu Asn Ser Val Ile
                 350                 355                 360

 tac acc aat caa cct aca gcc cag tat cac cag cag ttt aac acc agc     1635
 Tyr Thr Asn Gln Pro Thr Ala Gln Tyr His Gln Gln Phe Asn Thr Ser
             365                 370                 375

 agc cgc taa gttcagg atgtctatct ctctctccct tctcctccat caagctcaca     1691
 Ser Arg 


 ggtggttagg agtcaaagag aaaaatgctg catactccca ccttctaacc taggtaataa   1751

 agttctgcac tcaaaatcaa aaaaaaa                                       1778




      <210> 120
      <211> 678
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (229)..(486)

      <400> 120
 aatacattgt gccttttaag tttggtttgg ttgttgttgt tgttgtttta cttatttcaa     60

 acattgcttc tttagctcct gactttttac ttatatgcag atgaaacccg aaattgattt    120

 gtattttatt tcttttaagt caggtgccac tgtcaagagc tcaaacacga gtcggttcca    180

 agatggccga atggaaacag ctctggtgtg cagctcccag tgggattg atg cag aag     237
                                                      Met Gln Lys
                                                        1

 aca gtg att tct gca ttt cga act gag gta cct ggt tca tct cat tgg      285
 Thr Val Ile Ser Ala Phe Arg Thr Glu Val Pro Gly Ser Ser His Trp
       5                  10                  15

 gac tgg ttg gac agt gag tgc agc cca aag agg gcg agc cga agc agg      333
 Asp Trp Leu Asp Ser Glu Cys Ser Pro Lys Arg Ala Ser Arg Ser Arg
  20                  25                  30                  35

 gtg ggg cat tgc ctc acc tgg gaa gcg caa ggg gtc ggg gaa ttc cct      381
 Val Gly His Cys Leu Thr Trp Glu Ala Gln Gly Val Gly Glu Phe Pro
                  40                  45                  50

 ttc cca gcc aag gga atc cat ggc aga ttg tac ctg gaa aat cag gac      429
 Phe Pro Ala Lys Gly Ile His Gly Arg Leu Tyr Leu Glu Asn Gln Asp
              55                  60                  65

 act ccc gcc caa ata ctg cgc ttt tcc aat ggc ctt agc aaa tgg cac      477
 Thr Pro Ala Gln Ile Leu Arg Phe Ser Asn Gly Leu Ser Lys Trp His
          70                  75                  80

 ctg gct tag caggtcc cacacctaag aagccttgct cactgtagcg cagcagtctg      533
 Leu Ala 
      85

 agatcaaccg gtgaggcagc agcctagtag ggggagaggc gtctgccact gctgaagctt    593

 gagtaggtaa acaaagcggc tggggaagct cgcatatggc agagcccagt cgacgcggcc    653

 gcgaatttag tagtagtagg cggca                                          678




      <210> 121
      <211> 3690
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (55)..(3690)

      <400> 121
 cgaattcccg ggtcgacgat ttcgtagttg agacacttcg agagtgaaaa tata  atg      57
                                                              Met
                                                                1

 agc cca gcg tgt gtg gtt tct cct cat gca acc tac tcc acc agc atc      105
 Ser Pro Ala Cys Val Val Ser Pro His Ala Thr Tyr Ser Thr Ser Ile
               5                  10                  15

 atc cca aat gcc aca ctg tct tcc tct tcc gag gtc atc gct att ccc      153
 Ile Pro Asn Ala Thr Leu Ser Ser Ser Ser Glu Val Ile Ala Ile Pro
          20                  25                  30

 act gct cag agt gcg gga cag cgg gaa agt aaa agt tct ggc tca tca      201
 Thr Ala Gln Ser Ala Gly Gln Arg Glu Ser Lys Ser Ser Gly Ser Ser
      35                  40                  45

 cat gca agg ata aaa tcc aga gac cac ctc atc tcc agg cat gct gtg      249
 His Ala Arg Ile Lys Ser Arg Asp His Leu Ile Ser Arg His Ala Val
  50                  55                  60                  65

 aaa ggt gat cct cag tct ccc ggt cgc cac tgg aat gag ggc cat gcc      297
 Lys Gly Asp Pro Gln Ser Pro Gly Arg His Trp Asn Glu Gly His Ala
                  70                  75                  80

 acc att ctt tca cag gac tta gac cct cat tcc cct ggt gaa ccc gca      345
 Thr Ile Leu Ser Gln Asp Leu Asp Pro His Ser Pro Gly Glu Pro Ala
              85                  90                  95

 ctg ttg gcc ctc tgt gac tca gcc gtc cct cta aat gct cca gca aat      393
 Leu Leu Ala Leu Cys Asp Ser Ala Val Pro Leu Asn Ala Pro Ala Asn
         100                 105                 110

 agg gag aat ggg tcc caa gct atg ccg tat aat tgt aga aac aac ctg      441
 Arg Glu Asn Gly Ser Gln Ala Met Pro Tyr Asn Cys Arg Asn Asn Leu
     115                 120                 125

 gcc ttc cca gcc cac ccc caa gat gtg gat ggc aag agt gaa tct agt      489
 Ala Phe Pro Ala His Pro Gln Asp Val Asp Gly Lys Ser Glu Ser Ser
 130                 135                 140                 145

 tat tca ggg ggc gga ggg cac agc agc tcg gag ccc tgg gaa tac aaa      537
 Tyr Ser Gly Gly Gly Gly His Ser Ser Ser Glu Pro Trp Glu Tyr Lys
                 150                 155                 160

 tcc tca ggt aat gga agg gca tcc ccc ctg aag ccg cat tta gca act      585
 Ser Ser Gly Asn Gly Arg Ala Ser Pro Leu Lys Pro His Leu Ala Thr
             165                 170                 175

 cct ggc tat tcc act ccc aca agt aac atg agc agc tgc agt ttg gac      633
 Pro Gly Tyr Ser Thr Pro Thr Ser Asn Met Ser Ser Cys Ser Leu Asp
         180                 185                 190

 caa acg tcc aac aaa gag gat gct ggg tcg ctg tat tct gag gac cac      681
 Gln Thr Ser Asn Lys Glu Asp Ala Gly Ser Leu Tyr Ser Glu Asp His
     195                 200                 205

 gat ggc tac tgt gca tct gtg cac act gac tct gga cat gga tct ggg      729
 Asp Gly Tyr Cys Ala Ser Val His Thr Asp Ser Gly His Gly Ser Gly
 210                 215                 220                 225

 aat ctg tgc aat agc agt gat ggc ttt ggg aac ccc agg cac agc gtg      777
 Asn Leu Cys Asn Ser Ser Asp Gly Phe Gly Asn Pro Arg His Ser Val
                 230                 235                 240

 atc aat gtt ttt gtt gga aga gct cag aaa aac caa ggg gac cgg tcc      825
 Ile Asn Val Phe Val Gly Arg Ala Gln Lys Asn Gln Gly Asp Arg Ser
             245                 250                 255

 aat tac cag gat aaa tcc cta tca aga aac atc tct ttg aag aaa gca      873
 Asn Tyr Gln Asp Lys Ser Leu Ser Arg Asn Ile Ser Leu Lys Lys Ala
         260                 265                 270

 aag aag cct ccc ctg cca ccc tcc cgg aca gac tcc ctc cgc agg att      921
 Lys Lys Pro Pro Leu Pro Pro Ser Arg Thr Asp Ser Leu Arg Arg Ile
     275                 280                 285

 ccc aag aag agc agc cag tgc aac ggg cag gtg ctc aac gag agc ctg      969
 Pro Lys Lys Ser Ser Gln Cys Asn Gly Gln Val Leu Asn Glu Ser Leu
 290                 295                 300                 305

 atc gcc aca ctc cag cac tcg ctg cag ctg agc ctc cca ggc aaa agt     1017
 Ile Ala Thr Leu Gln His Ser Leu Gln Leu Ser Leu Pro Gly Lys Ser
                 310                 315                 320

 ggc agc tcg ccc tcc cag agc ccc tgc agt gac ttg gaa gag ccc tgg     1065
 Gly Ser Ser Pro Ser Gln Ser Pro Cys Ser Asp Leu Glu Glu Pro Trp
             325                 330                 335

 ctg ccc cgc tcc cgg agc cag agc aca gtt agt gct ggc agc agc atg     1113
 Leu Pro Arg Ser Arg Ser Gln Ser Thr Val Ser Ala Gly Ser Ser Met
         340                 345                 350

 act tcc gcc acc acc ccc aat gtc tac tcc ctg tgc ggg gcc acg cca     1161
 Thr Ser Ala Thr Thr Pro Asn Val Tyr Ser Leu Cys Gly Ala Thr Pro
     355                 360                 365

 tcg cag agt gac aca agc agc gtc aag tca gag tac acg gac ccc tgg     1209
 Ser Gln Ser Asp Thr Ser Ser Val Lys Ser Glu Tyr Thr Asp Pro Trp
 370                 375                 380                 385

 ggt tat tac att gac tac acg ggc atg cag gaa gat ccg ggg aac ccg     1257
 Gly Tyr Tyr Ile Asp Tyr Thr Gly Met Gln Glu Asp Pro Gly Asn Pro
                 390                 395                 400

 gca ggg ggc tgt tca acc agc agt ggg gtg ccc act ggg aac ggg cca     1305
 Ala Gly Gly Cys Ser Thr Ser Ser Gly Val Pro Thr Gly Asn Gly Pro
             405                 410                 415

 gtc cgc cat gtc caa gaa ggg tcc aga gcc aca atg ccc caa gtg ccc     1353
 Val Arg His Val Gln Glu Gly Ser Arg Ala Thr Met Pro Gln Val Pro
         420                 425                 430

 ggt ggt tca gtc aaa cca aag atc atg tca cca gag aag tca cac aga     1401
 Gly Gly Ser Val Lys Pro Lys Ile Met Ser Pro Glu Lys Ser His Arg
     435                 440                 445

 gtc att tct cca tcc agt ggg tat tcc agc cag tcg aat aca ccc aca     1449
 Val Ile Ser Pro Ser Ser Gly Tyr Ser Ser Gln Ser Asn Thr Pro Thr
 450                 455                 460                 465

 gca ctc acc cct gtg cct gtg ttt tta aaa tca gtg tca cca gca aac     1497
 Ala Leu Thr Pro Val Pro Val Phe Leu Lys Ser Val Ser Pro Ala Asn
                 470                 475                 480

 ggg aag ggg aag ccc aag ccc aag gta cca gaa agg aag tcc tct ctg     1545
 Gly Lys Gly Lys Pro Lys Pro Lys Val Pro Glu Arg Lys Ser Ser Leu
             485                 490                 495

 ata tct tca gta tcc att tcc tca tcg tcc act tct ctt tct tct agt     1593
 Ile Ser Ser Val Ser Ile Ser Ser Ser Ser Thr Ser Leu Ser Ser Ser
         500                 505                 510

 act tct act gaa gga agt ggc act atg aag aag ctg gat cca gcc gtg     1641
 Thr Ser Thr Glu Gly Ser Gly Thr Met Lys Lys Leu Asp Pro Ala Val
     515                 520                 525

 ggc tct ccc ccg gct cct cct cct cct cct gtt ccc tct cct cca ttc     1689
 Gly Ser Pro Pro Ala Pro Pro Pro Pro Pro Val Pro Ser Pro Pro Phe
 530                 535                 540                 545

 cct tgt cct gca gac agg tct cct ttc ctt cct ccc cca cct cct gtc     1737
 Pro Cys Pro Ala Asp Arg Ser Pro Phe Leu Pro Pro Pro Pro Pro Val
                 550                 555                 560

 aca gat tgc tcc cag ggc tct cct ctg cct cac tct cct gtg ttc ccc     1785
 Thr Asp Cys Ser Gln Gly Ser Pro Leu Pro His Ser Pro Val Phe Pro
             565                 570                 575

 cct ccg ccg cca gaa gct ctc att cct ttc tgc tcc cca cct gat tgg     1833
 Pro Pro Pro Pro Glu Ala Leu Ile Pro Phe Cys Ser Pro Pro Asp Trp
         580                 585                 590

 tgc ctt tct cct ccc cgc cct gca ctg agc ccc att ctt cca gat tca     1881
 Cys Leu Ser Pro Pro Arg Pro Ala Leu Ser Pro Ile Leu Pro Asp Ser
     595                 600                 605

 cct gtg tcc ttg cca ttg ccc cca cct ctc tta cct tcc tcg gaa ccc     1929
 Pro Val Ser Leu Pro Leu Pro Pro Pro Leu Leu Pro Ser Ser Glu Pro
 610                 615                 620                 625

 cca cct gcc cca cct ctt gac ccc aaa ttc atg aaa gac acc agg ccg     1977
 Pro Pro Ala Pro Pro Leu Asp Pro Lys Phe Met Lys Asp Thr Arg Pro
                 630                 635                 640

 cct ttc aca aat tct ggc cag cca gaa tcc tcc cgg gga tcc ttg agg     2025
 Pro Phe Thr Asn Ser Gly Gln Pro Glu Ser Ser Arg Gly Ser Leu Arg
             645                 650                 655

 ccg cct tct acc aag gag gag acc agc agg ccc ccc atg ccc ctg ata     2073
 Pro Pro Ser Thr Lys Glu Glu Thr Ser Arg Pro Pro Met Pro Leu Ile
         660                 665                 670

 acc acg gaa gca ttg cag atg gtg cag ttg agg ccc gtg aga aag aac     2121
 Thr Thr Glu Ala Leu Gln Met Val Gln Leu Arg Pro Val Arg Lys Asn
     675                 680                 685

 tca ggc gct gag gcg gca cag ttg tct gaa cga aca gct cag gaa caa     2169
 Ser Gly Ala Glu Ala Ala Gln Leu Ser Glu Arg Thr Ala Gln Glu Gln
 690                 695                 700                 705

 cga act cca gtt gct cca cag tac cac tta aag cca tct gct ttc ctg     2217
 Arg Thr Pro Val Ala Pro Gln Tyr His Leu Lys Pro Ser Ala Phe Leu
                 710                 715                 720

 aaa tcc cga aat agc aca aat gaa atg gag agt gaa agc cag cct gcc     2265
 Lys Ser Arg Asn Ser Thr Asn Glu Met Glu Ser Glu Ser Gln Pro Ala
             725                 730                 735

 tct gtg aca agc tcg ctt ccg acg cct gcc aag agc tcg agt cag ggt     2313
 Ser Val Thr Ser Ser Leu Pro Thr Pro Ala Lys Ser Ser Ser Gln Gly
         740                 745                 750

 gac cat ggc agt gcg gct gag cgt ggt ggc cct gtg agc cgc agc cct     2361
 Asp His Gly Ser Ala Ala Glu Arg Gly Gly Pro Val Ser Arg Ser Pro
     755                 760                 765

 gga gct cca agc gct ggg gag gca gag gct cgg ccc agc ccc agc acc     2409
 Gly Ala Pro Ser Ala Gly Glu Ala Glu Ala Arg Pro Ser Pro Ser Thr
 770                 775                 780                 785

 acc cca ctc cca gac tct tca ccc agc agg aag cca ccc ccc att tcc     2457
 Thr Pro Leu Pro Asp Ser Ser Pro Ser Arg Lys Pro Pro Pro Ile Ser
                 790                 795                 800

 aag aag ccc aaa ctg ttc ctg gtg gta cca cct ccg cag aaa gat ttt     2505
 Lys Lys Pro Lys Leu Phe Leu Val Val Pro Pro Pro Gln Lys Asp Phe
             805                 810                 815

 gca gtg gag ccc gca gag aac gtg agc gaa gcc ctc cga gct gtg ccc     2553
 Ala Val Glu Pro Ala Glu Asn Val Ser Glu Ala Leu Arg Ala Val Pro
         820                 825                 830

 agc ccc acg acg gga gag gag ggc tct gtg cac agc agg gag gca aaa     2601
 Ser Pro Thr Thr Gly Glu Glu Gly Ser Val His Ser Arg Glu Ala Lys
     835                 840                 845

 gag agt tct gca gcc caa gct ggc tct cat gcc acg cac cct ggc acc     2649
 Glu Ser Ser Ala Ala Gln Ala Gly Ser His Ala Thr His Pro Gly Thr
 850                 855                 860                 865

 tcg gtt ctt gag gga gga gct gca gga tcc atg tct ccc agc aga gtg     2697
 Ser Val Leu Glu Gly Gly Ala Ala Gly Ser Met Ser Pro Ser Arg Val
                 870                 875                 880

 gaa gcc aat gtc ccc atg gtt cag cct gat gtc tca cca gcc ccc aag     2745
 Glu Ala Asn Val Pro Met Val Gln Pro Asp Val Ser Pro Ala Pro Lys
             885                 890                 895

 cag gag gag cca gcc gag aac agt gcg gat act ggg ggc gat ggg gag     2793
 Gln Glu Glu Pro Ala Glu Asn Ser Ala Asp Thr Gly Gly Asp Gly Glu
         900                 905                 910

 agc tgc cta tct caa cag gac gga gca gct ggg gtg ccg gag acc aac     2841
 Ser Cys Leu Ser Gln Gln Asp Gly Ala Ala Gly Val Pro Glu Thr Asn
     915                 920                 925

 gca gcc ggt tca tcc tca gag gcc tgt gac ttc ctc aag gaa gac ggg     2889
 Ala Ala Gly Ser Ser Ser Glu Ala Cys Asp Phe Leu Lys Glu Asp Gly
 930                 935                 940                 945

 aat gat gag gta atg acc ccc agt cga ccc agg acc aca gaa gac ctt     2937
 Asn Asp Glu Val Met Thr Pro Ser Arg Pro Arg Thr Thr Glu Asp Leu
                 950                 955                 960

 ttt gca gct att cac aga tcc aaa agg aaa gtc ctc ggc cgt aga gat     2985
 Phe Ala Ala Ile His Arg Ser Lys Arg Lys Val Leu Gly Arg Arg Asp
             965                 970                 975

 tca gat gat gac cac tcc cga aac cat tct ccc tcc ccg ccc gtg aca     3033
 Ser Asp Asp Asp His Ser Arg Asn His Ser Pro Ser Pro Pro Val Thr
         980                 985                 990

 ccc acc ggc gct gcc cca agc ctg gcc tct cca aag caa gtg ggg tcg     3081
 Pro Thr Gly Ala Ala Pro Ser Leu Ala Ser Pro Lys Gln Val Gly Ser
     995                1000                1005

 att cag aga agc atc cga aag agc agc acc agc agt gac aac ttc aaa     3129
 Ile Gln Arg Ser Ile Arg Lys Ser Ser Thr Ser Ser Asp Asn Phe Lys
1010                1015                1020                1025

 gct ctg ctg ctg aaa aag ggc agt cgt tca gac acc agc gcc cgc atg     3177
 Ala Leu Leu Leu Lys Lys Gly Ser Arg Ser Asp Thr Ser Ala Arg Met
                1030                1035                1040

 tct gca gca gag atg ctc aag aac aca gac cct aga ttc cag agg tcg     3225
 Ser Ala Ala Glu Met Leu Lys Asn Thr Asp Pro Arg Phe Gln Arg Ser
            1045                1050                1055

 agg tca gag cct tcc cca gat gcc ccc gag agc ccg tca agc tgc tcc     3273
 Arg Ser Glu Pro Ser Pro Asp Ala Pro Glu Ser Pro Ser Ser Cys Ser
        1060                1065                1070

 cca agc aag aac aga agg gcg cag gag gag tgg gcc aag aac gaa ggc     3321
 Pro Ser Lys Asn Arg Arg Ala Gln Glu Glu Trp Ala Lys Asn Glu Gly
    1075                1080                1085

 ttg atg cct cgg agt ctg tcc ttt tcc ggc ccc agg tac ggc cgc agc     3369
 Leu Met Pro Arg Ser Leu Ser Phe Ser Gly Pro Arg Tyr Gly Arg Ser
1090                1095                1100                1105

 cga acg ccg cct tct gcc gcc agc agc agg tac agc atg cgg aac cgg     3417
 Arg Thr Pro Pro Ser Ala Ala Ser Ser Arg Tyr Ser Met Arg Asn Arg
                1110                1115                1120

 atc cag agc agc ccc atg acc gtc atc tcg gag gga gaa ggg gaa gcc     3465
 Ile Gln Ser Ser Pro Met Thr Val Ile Ser Glu Gly Glu Gly Glu Ala
            1125                1130                1135

 gtg gag cct gtg gac agc ata gcc cgc ggg gct ctg ggc gct gcg gag     3513
 Val Glu Pro Val Asp Ser Ile Ala Arg Gly Ala Leu Gly Ala Ala Glu
        1140                1145                1150

 gga tgt tcc ctg gac gga ctg gcg agg gag gag atg gac gag ggc ggc     3561
 Gly Cys Ser Leu Asp Gly Leu Ala Arg Glu Glu Met Asp Glu Gly Gly
    1155                1160                1165

 ctg ctc tgt ggg gag ggg cct gcc gcc tcc ctg cag ccc cag gcc ccc     3609
 Leu Leu Cys Gly Glu Gly Pro Ala Ala Ser Leu Gln Pro Gln Ala Pro
1170                1175                1180                1185

 ggc cct gtg gat ggg aca gcc agt gca gag ggc aga gag ccc tcc cca     3657
 Gly Pro Val Asp Gly Thr Ala Ser Ala Glu Gly Arg Glu Pro Ser Pro
                1190                1195                1200

 cag tgt ggc ggt tct ctg agc gag gag agt tag                         3690
 Gln Cys Gly Gly Ser Leu Ser Glu Glu Ser 
            1205                1210





      <210> 122
      <211> 537
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (82)..(411)

      <400> 122
 ggggattccg ggtcgaccac gcgtccgccc acgcgtccgg gcggggtcgg cgctgccggg     60

 tgaaatcgta ggacagtgaa g  atg ctg ctg gaa ttg tcc gag gag cat aag     111
                          Met Leu Leu Glu Leu Ser Glu Glu His Lys
                            1               5                  10

 gaa cac ctg gcc ttc ctg cct caa gtg gac agc gcg ggt cag cgg gcg      159
 Glu His Leu Ala Phe Leu Pro Gln Val Asp Ser Ala Gly Gln Arg Ala
                  15                  20                  25

 tgg ggg cgg tgt tct gtg ggc tgg gga gga ggt caa agg cag cgc ctg      207
 Trp Gly Arg Cys Ser Val Gly Trp Gly Gly Gly Gln Arg Gln Arg Leu
              30                  35                  40

 gca ctc aac agc ctt ctg act ttc att gca gtg gtc gcc gag ttt ggg      255
 Ala Leu Asn Ser Leu Leu Thr Phe Ile Ala Val Val Ala Glu Phe Gly
          45                  50                  55

 cgg att gct gtg gaa ttc ctg aga cgc ggc gca aac cca aaa atc tac      303
 Arg Ile Ala Val Glu Phe Leu Arg Arg Gly Ala Asn Pro Lys Ile Tyr
      60                  65                  70

 gaa ggc gcc gcc agt aag aag gga aag ggg aag gct ccg cag gct tct      351
 Glu Gly Ala Ala Ser Lys Lys Gly Lys Gly Lys Ala Pro Gln Ala Ser
  75                  80                  85                  90

 agg gcg gtt gcg agc cat tcc ctg tct ccc ggg aga gaa acg gat tat      399
 Arg Ala Val Ala Ser His Ser Leu Ser Pro Gly Arg Glu Thr Asp Tyr
                  95                 100                 105

 tgc gag tcc tag ggt cttgttccga ttgtagtaga ataaaaccag cagagctctt      454
 Cys Glu Ser 


 cagtcagggt gcaaatcctg cccgtccctt aagtagctgt gagattgtta aagcttctat    514

 taaatcagat ttctcatggt aag                                            537




      <210> 123
      <211> 447
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (82)..(321)

      <400> 123
 ggggattccg ggtcgaccac gcgtccgccc acgcgtccgg gcggggtcgg cgctgccggg     60

 tgaaatcgta ggacagtgaa g  atg ctg ctg gaa ttg tcc gag gag cat aag     111
                          Met Leu Leu Glu Leu Ser Glu Glu His Lys
                            1               5                  10

 gaa cac ctg gcc ttc ctg cct caa gtg gac agc gcg gtg gtc gcc gag      159
 Glu His Leu Ala Phe Leu Pro Gln Val Asp Ser Ala Val Val Ala Glu
                  15                  20                  25

 ttt ggg cgg att gct gtg gaa ttc ctg aga cgc ggc gca aac cca aaa      207
 Phe Gly Arg Ile Ala Val Glu Phe Leu Arg Arg Gly Ala Asn Pro Lys
              30                  35                  40

 atc tac gaa ggc gcc gcc agt aag aag gga aag ggg aag gct ccg cag      255
 Ile Tyr Glu Gly Ala Ala Ser Lys Lys Gly Lys Gly Lys Ala Pro Gln
          45                  50                  55

 gct tct agg gcg gtt gcg agc cat tcc ctg tct ccc ggg aga gaa acg      303
 Ala Ser Arg Ala Val Ala Ser His Ser Leu Ser Pro Gly Arg Glu Thr
      60                  65                  70

 gat tat tgc gag tcc tag ggtctt gttccgattg tagtagaata aaaccagcag      357
 Asp Tyr Cys Glu Ser 
  75

 agctcttcag tcagggtgca aatcctgccc gtcccttaag tagctgtgag attgttaaag    417

 cttctattaa atcagatttc tcatggtaag                                     447




      <210> 124
      <211> 3699
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (172)..(1257)

      <400> 124
 gcacgcaccg acccggaatt cccgggtcga cgatttcgtc cgaggttgga gcggcgctgc     60

 tcggccgcgg acacacgagg gacgcgcccg aggagctgca ggtggcagcc caggcggtcc    120

 gaacccgtcg gccggccgag cctggagtat tgcctaagtg taatcttgaa c atg ggc     177
                                                          Met Gly
                                                            1

 ggt gct gtg agt gct ggt gaa gac aat gat gag ctg ata gat aat ttg      225
 Gly Ala Val Ser Ala Gly Glu Asp Asn Asp Glu Leu Ile Asp Asn Leu
           5                  10                  15

 aaa gaa gca cag tat atc cgg act gag ctg gta gag cag gct ttc aga      273
 Lys Glu Ala Gln Tyr Ile Arg Thr Glu Leu Val Glu Gln Ala Phe Arg
      20                  25                  30

 gct atc gat cgt gca gac tat tat ctt gaa gaa ttt aaa gaa aat gct      321
 Ala Ile Asp Arg Ala Asp Tyr Tyr Leu Glu Glu Phe Lys Glu Asn Ala
  35                  40                  45                  50

 tat aaa gac ttg gca tgg aag cat gga aac att cac ctc tca gcc ccg      369
 Tyr Lys Asp Leu Ala Trp Lys His Gly Asn Ile His Leu Ser Ala Pro
                  55                  60                  65

 tgc atc tac tcg gag gtg atg gaa gcc cta gat ctg cag cct gga ctc      417
 Cys Ile Tyr Ser Glu Val Met Glu Ala Leu Asp Leu Gln Pro Gly Leu
              70                  75                  80

 tcg ttt ctg aac ctg ggc agt ggc act ggg tat ctc agc tcc atg gtg      465
 Ser Phe Leu Asn Leu Gly Ser Gly Thr Gly Tyr Leu Ser Ser Met Val
          85                  90                  95

 ggc ctc att cta ggt cct ttt ggt gtg aac cat ggg gtg gaa ctt cac      513
 Gly Leu Ile Leu Gly Pro Phe Gly Val Asn His Gly Val Glu Leu His
     100                 105                 110

 tca gat gtg ata gag tat gca aag cag aaa ctg gac ttc ttc atc aga      561
 Ser Asp Val Ile Glu Tyr Ala Lys Gln Lys Leu Asp Phe Phe Ile Arg
 115                 120                 125                 130

 aca agt gat agt ttt gac aag ttt gac ttc tgt gaa cct tcc ttt gtt      609
 Thr Ser Asp Ser Phe Asp Lys Phe Asp Phe Cys Glu Pro Ser Phe Val
                 135                 140                 145

 act ggg aat tgc ctg gag att tct ccg gat tgt tct cag tat gat cgt      657
 Thr Gly Asn Cys Leu Glu Ile Ser Pro Asp Cys Ser Gln Tyr Asp Arg
             150                 155                 160

 gta tac tgt ggg gct ggc gtg cag aaa gag cat gaa gag tac atg aag      705
 Val Tyr Cys Gly Ala Gly Val Gln Lys Glu His Glu Glu Tyr Met Lys
         165                 170                 175

 aat ctt ctc aaa gtg gga ggg atc ctt gtc atg cca ctg gaa gag aag      753
 Asn Leu Leu Lys Val Gly Gly Ile Leu Val Met Pro Leu Glu Glu Lys
     180                 185                 190

 ttg act aag ata aca cgc aca ggt cct tca gct tgg gaa acc aaa aag      801
 Leu Thr Lys Ile Thr Arg Thr Gly Pro Ser Ala Trp Glu Thr Lys Lys
 195                 200                 205                 210

 att ctt gct gtt tct ttt gct cct ctg atc cag ccc tgc cat tca gag      849
 Ile Leu Ala Val Ser Phe Ala Pro Leu Ile Gln Pro Cys His Ser Glu
                 215                 220                 225

 tca gga aaa tca aga ctt gtc cag tta cca cca gtg gca gtt cgc agc      897
 Ser Gly Lys Ser Arg Leu Val Gln Leu Pro Pro Val Ala Val Arg Ser
             230                 235                 240

 ctc cag gac ttg gct cgc atc gcc atc cgg ggc acc att aaa aag att      945
 Leu Gln Asp Leu Ala Arg Ile Ala Ile Arg Gly Thr Ile Lys Lys Ile
         245                 250                 255

 att cat cag gaa act gtg agc aaa aac gga aac gga cta aag aac acc      993
 Ile His Gln Glu Thr Val Ser Lys Asn Gly Asn Gly Leu Lys Asn Thr
     260                 265                 270

 ccc agg ttt aaa cga agg aga gtt cgc cgc cgt cga atg gaa acg att     1041
 Pro Arg Phe Lys Arg Arg Arg Val Arg Arg Arg Arg Met Glu Thr Ile
 275                 280                 285                 290

 gtc ttt ttg gac aaa gaa gtc ttt gcc agt cgg att tcc aac ccc tca     1089
 Val Phe Leu Asp Lys Glu Val Phe Ala Ser Arg Ile Ser Asn Pro Ser
                 295                 300                 305

 gat gac aac agc tgt gaa gac ttg gaa gag gaa cgg agg gaa gaa gaa     1137
 Asp Asp Asn Ser Cys Glu Asp Leu Glu Glu Glu Arg Arg Glu Glu Glu
             310                 315                 320

 gag aag acc ccg ccg gaa aca aag cca gac ccc cca gtg aac ttc cta     1185
 Glu Lys Thr Pro Pro Glu Thr Lys Pro Asp Pro Pro Val Asn Phe Leu
         325                 330                 335

 cgc cag aag gtc ctg agc ctc cct ctg cca gat ccc ctg aaa tac tac     1233
 Arg Gln Lys Val Leu Ser Leu Pro Leu Pro Asp Pro Leu Lys Tyr Tyr
     340                 345                 350

 ttg ctt tat tac aga gaa aaa taa gtctcctgtt tgaaaggggg aaataggaag    1287
 Leu Leu Tyr Tyr Arg Glu Lys 
 355                 360

 agcagattgc tgagtgtgaa gttcgtgctg cctgtgtgct gttgaagggt cacctggagg   1347

 cagacgttgt ggggaaggga actgctgggc tcatccacac catggttttc ttctagttcc   1407

 tgattgacct ctaaaattct attcagttgt atgatttgtt tacatagttc cacaagacct   1467

 tcattgcata gaagattgtt ttcccaaagt ggagagaatc ttcatagaga aaaagagaag   1527

 gctgtttctt tttcggctct gacgaaacac tgaagtctgc gtaagagaga ctgtttgatg   1587

 accgtccctc atgcaacatg cacggtactc actaaaaatg aaaactgaag tggaaactaa   1647

 cctgtgttgc ttataaagtg tgaaagcaca agcttataaa tgtataaaat cttttctggg   1707

 tgtgacgcac ctgcgtccaa gtttgaattt ttatgatatg taccacttaa ttactggcac   1767

 tgagtatcac tgaatttctt agttttctag tggggaaaca ttattgagaa gccctccctt   1827

 attttaagta agttgattaa atcttatgtg agttgccagt tgtaattttt caaaggaaaa   1887

 attttgatgg ggtggaggaa tgaattgcca gataatcttt ctggaattcc gagagaattc   1947

 caaagagggt tttttttttt ttttttttag gacatctttt gataccttta aaagaaccac   2007

 tgtcaagtaa tccttaaaaa aatatcttgg aaaaggaaac agattttttc ctgtgtgtaa   2067

 gcaataagtg aagttacatt tgccctaacc ctagggatga ttctttaccc agttttaaag   2127

 cccatcatgg tattctaagg tgttgacacc ctccatcctc agagcaggtc gaaaatatta   2187

 aatagactgg ggactctatg atgggcagcc tgtgcttttt gacttcagtt tgctattttt   2247

 ctgtgatcac attagtactg attcatagat tctatctttt ataattctgg agaaaaagat   2307

 ttgttagttt tgtaattttt ttgtaagacc aaatgtatgt attttagtag ctccattgca   2367

 tgagaagagt gtaactcaca ctgacttgtg atatcagcct tctctgggcc ttgtgtgtgg   2427

 agagctttct atcttaccaa gtggtagggc taaaagaaca acagcctttt tggtagtcac   2487

 atagcagaat gatcagagtt acattgctta ttccaaaaca ttggttcttt ttaaaacatt   2547

 tttttttacc caaagaaaag aataatagaa attactaaca ataaatataa attcagagtg   2607

 ttgatatagg attcagtatc cagagtttat ttttaatctt aatcctcagc ttcttgggag   2667

 ttgctgggct tcagtgtctc tgtggtttca ccagcttagc ttgagctctg gttattttgg   2727

 atcttttctg ctttttttaa gtaactgagt catttttacc acacagtcca gtttgcatgt   2787

 atagctagga aacatgtatt gctctagatt gggcagttta agtcatttta aagaaagtta   2847

 gttcatagtt gttgcctttt aactcatagt caagcttcag tctttcaaag agaaatgtgt   2907

 gattttcatt tacttgctga tattttgtag tttggagatc cttgtgggca ttattctaac   2967

 tgatacgtag acacttactt ggaaattttt ggacattata ttaaatgagt gctatctgtg   3027

 aaattggtta tattaggtgg cttgactaat gttttttcta taattgtata tggactgcat   3087

 ttttaaaaaa accgcatttg cctttatgct agattgtaaa aaattatatt agaatgcata   3147

 agacatgttt ttccttcata tgctagactt ttcctagcat ttcgtatttc tgtgttgtca   3207

 gtgtgtgatt tttaaaccgg aatttggttt aaaaaaaatc tggtggtaat atatgtgaga   3267

 aatactttgg tgtttacctt atgaaaataa aggattgtaa gtaaagtttc ctgcgcacct   3327

 tataccagaa ttcagtataa tacactactt tctgttttca aacagataaa tcataatata   3387

 gtctgtatta tctgtaagat ctgtcttgta aaccacattc ttgacaacta tttgcttttg   3447

 agtagtttgt attttaatat gtgacttttg tcttgaaaag tagtaaagcc atagacttgt   3507

 gcaaaacaag tttcaagttt atagatatta agtttgtaat gtgagcatca aatgtgtatg   3567

 taaaaatact ttttaccagt ctggaacttg ggaaaatcca gggaatttga aacatagatt   3627

 ttaatgagct ggtaaacaca aatcatgtca ataaaggtag tcaggatatt ttatccttag   3687

 cattgcttct gc                                                       3699




      <210> 125
      <211> 3749
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (624)..(2735)

      <220>
      <221> misc_feature
      <222> (1)...(3749)
      <223> n = a,t,c or g

      <400> 125
 gcacgagcag aagggcaaaa gctcgcttga tcttgatttt cagtacgaat acagaccgtg     60

 aaagcggggc ctcacgatcc ttctgacctt ttgggtttta agcaggaggt gtcagaaaag    120

 ttaccacagg gataactggc ttgtggcggc caagcgttca tagcgacgtc gctttttgat    180

 ccttcgatgt cggctcttcc tatcattgtg aagcagaatt caccaagcgt tggattgttc    240

 acccactaat agggaacgtg agctggggtt agaccgtcgt gagacaggtt agttttaccc    300

 tactgatgat gtgttgttgc catggtaatc ctgctcagta cgagaggaac cgcaggttca    360

 gacatttggt gtatgtgctt ggctgangag ccaatggggc gaagctacca tctgtgggat    420

 tatgactgaa cgcctctaag tcagaatccc gcccaggcgg cgtcggccgg atcgggccgc    480

 gacacctcct ggccatgggg gacgtgctgt ccacgcacct ggacgacgcc cggcgccagc    540

 acatcgcaga aaaaaccggg aagatcctga cggagttcct ccagttctat gaagaccagt    600

 atggcgtggc tctcttcaac agc    atg cgc cat gag att gag ggc acg ggg     650
                              Met Arg His Glu Ile Glu Gly Thr Gly
                                1               5

 ctg ccg cag gcc cag ctg ctc tgg cgc aag gtg cca ctg gac gag cgc      698
 Leu Pro Gln Ala Gln Leu Leu Trp Arg Lys Val Pro Leu Asp Glu Arg
  10                  15                  20                  25

 atc gtc ttc tcg ggg aac ctc ttc cag cac cag gag gac agc aag aag      746
 Ile Val Phe Ser Gly Asn Leu Phe Gln His Gln Glu Asp Ser Lys Lys
                  30                  35                  40

 tgg aga aac cgc ttc agc ctc gtg ccc cac aac tac ggg ctg gtg ctc      794
 Trp Arg Asn Arg Phe Ser Leu Val Pro His Asn Tyr Gly Leu Val Leu
              45                  50                  55

 tac gaa aac aaa gcg gcc tat gag cgg cag gtc cca cca cga gcc gtc      842
 Tyr Glu Asn Lys Ala Ala Tyr Glu Arg Gln Val Pro Pro Arg Ala Val
          60                  65                  70

 atc aac agt gca ggc tac aaa atc ctc acg tcc gtg gac caa tac ctg      890
 Ile Asn Ser Ala Gly Tyr Lys Ile Leu Thr Ser Val Asp Gln Tyr Leu
      75                  80                  85

 gag ctc att ggc aac tcc tta cca ggg acc acg gca aag tcg ggc agt      938
 Glu Leu Ile Gly Asn Ser Leu Pro Gly Thr Thr Ala Lys Ser Gly Ser
  90                  95                 100                 105

 gcc ccc atc ctc aag tgc ccc aca cag ttc ccg ctc atc ctc tgg cat      986
 Ala Pro Ile Leu Lys Cys Pro Thr Gln Phe Pro Leu Ile Leu Trp His
                 110                 115                 120

 cct tat gcg cgt cac tac tac ttc tgc atg atg aca gaa gcc gag cag     1034
 Pro Tyr Ala Arg His Tyr Tyr Phe Cys Met Met Thr Glu Ala Glu Gln
             125                 130                 135

 gac aag tgg cag gct gtg ctg cag gac tgc atc cgg cac tgc aac aat     1082
 Asp Lys Trp Gln Ala Val Leu Gln Asp Cys Ile Arg His Cys Asn Asn
         140                 145                 150

 gga atc cct gag gac tcc aag gta gag ggc cct gcg ttc aca gat gcc     1130
 Gly Ile Pro Glu Asp Ser Lys Val Glu Gly Pro Ala Phe Thr Asp Ala
     155                 160                 165

 atc cgc atg tac cga cag tcc aag gag ctg tac ggc acc tgg gag atg     1178
 Ile Arg Met Tyr Arg Gln Ser Lys Glu Leu Tyr Gly Thr Trp Glu Met
 170                 175                 180                 185

 ctg tgt ggg aac gag gtg cag atc ctg agc aac ctg gtg atg gag gag     1226
 Leu Cys Gly Asn Glu Val Gln Ile Leu Ser Asn Leu Val Met Glu Glu
                 190                 195                 200

 ctg ggc cct gag ctg aag gca gag ctc ggc ccg cgg ctg aag ggg aaa     1274
 Leu Gly Pro Glu Leu Lys Ala Glu Leu Gly Pro Arg Leu Lys Gly Lys
             205                 210                 215

 ccg cag gag cgg cag cgg cag tgg atc cag atc tcg gac gcc gtg tac     1322
 Pro Gln Glu Arg Gln Arg Gln Trp Ile Gln Ile Ser Asp Ala Val Tyr
         220                 225                 230

 cac atg gtg tac gag cag gcc aag gcg cgc ttc gag gag gtg ctg tcc     1370
 His Met Val Tyr Glu Gln Ala Lys Ala Arg Phe Glu Glu Val Leu Ser
     235                 240                 245

 aag gtg cag cag gtg cag ccg gcc atg cag gcc gtc atc cga act gac     1418
 Lys Val Gln Gln Val Gln Pro Ala Met Gln Ala Val Ile Arg Thr Asp
 250                 255                 260                 265

 atg gac caa att atc acc tcc aag gag cac ctt gcc agc aag atc cga     1466
 Met Asp Gln Ile Ile Thr Ser Lys Glu His Leu Ala Ser Lys Ile Arg
                 270                 275                 280

 gcc ttc atc ctc ccc aag gca gag gtg tgc gtg cgg aac cat gtc cag     1514
 Ala Phe Ile Leu Pro Lys Ala Glu Val Cys Val Arg Asn His Val Gln
             285                 290                 295

 ccc tac atc cca tcc atc ctg gag gcc ctg atg gtc ccc acc agc cag     1562
 Pro Tyr Ile Pro Ser Ile Leu Glu Ala Leu Met Val Pro Thr Ser Gln
         300                 305                 310

 ggc ttc act gag gtg cga gat gtc ttc ttc aag gag gtc acg gac atg     1610
 Gly Phe Thr Glu Val Arg Asp Val Phe Phe Lys Glu Val Thr Asp Met
     315                 320                 325

 aac ctg aac gtc atc aac gag ggc ggc att gac aag ctg ggc gag tac     1658
 Asn Leu Asn Val Ile Asn Glu Gly Gly Ile Asp Lys Leu Gly Glu Tyr
 330                 335                 340                 345

 atg gag aag ctg tcc cgg ctg gcg tac cac ccc ctg aag atg cag agc     1706
 Met Glu Lys Leu Ser Arg Leu Ala Tyr His Pro Leu Lys Met Gln Ser
                 350                 355                 360

 tgc tat gag aag atg gag tcg ctg cga ctg gac ggg ctg cag cag cga     1754
 Cys Tyr Glu Lys Met Glu Ser Leu Arg Leu Asp Gly Leu Gln Gln Arg
             365                 370                 375

 ttt gat gtg tcc agc acg tcc gtg ttc aag cag cga gcc cag atc cac     1802
 Phe Asp Val Ser Ser Thr Ser Val Phe Lys Gln Arg Ala Gln Ile His
         380                 385                 390

 atg cgg gag caa atg gac aat gcc gtg tat acg ttc gag acc ctc ctg     1850
 Met Arg Glu Gln Met Asp Asn Ala Val Tyr Thr Phe Glu Thr Leu Leu
     395                 400                 405

 cac cag gag ctg ggg aag ggg ccc acc aag gag gag ctg tgc aag tcc     1898
 His Gln Glu Leu Gly Lys Gly Pro Thr Lys Glu Glu Leu Cys Lys Ser
 410                 415                 420                 425

 atc cag cgg gtc ctg gag cgg gtg ctg aag aaa tac gac tac gac agc     1946
 Ile Gln Arg Val Leu Glu Arg Val Leu Lys Lys Tyr Asp Tyr Asp Ser
                 430                 435                 440

 agc tct gtg cgg aag agg ttc ttc cgg gag gcg ctg ctg cag atc agc     1994
 Ser Ser Val Arg Lys Arg Phe Phe Arg Glu Ala Leu Leu Gln Ile Ser
             445                 450                 455

 atc ccg ttc ctg ctc aag aag ctg gcc cct acc tgc aag tcg gag ctg     2042
 Ile Pro Phe Leu Leu Lys Lys Leu Ala Pro Thr Cys Lys Ser Glu Leu
         460                 465                 470

 ccc cgg ttc cag gag ctg atc ttc gag gac ttt gcc agg ttc atc ctg     2090
 Pro Arg Phe Gln Glu Leu Ile Phe Glu Asp Phe Ala Arg Phe Ile Leu
     475                 480                 485

 gtg gaa aac acg tac gag gag gtg gtg ctg cag acc gtc atg aag gac     2138
 Val Glu Asn Thr Tyr Glu Glu Val Val Leu Gln Thr Val Met Lys Asp
 490                 495                 500                 505

 atc ctg cag gct gtg aag gag gcc gcg gtg cag agg aag cac aac ctc     2186
 Ile Leu Gln Ala Val Lys Glu Ala Ala Val Gln Arg Lys His Asn Leu
                 510                 515                 520

 tac cgg gac agc atg gtc atg cac aac agc gac ccc aac ctg cac ctg     2234
 Tyr Arg Asp Ser Met Val Met His Asn Ser Asp Pro Asn Leu His Leu
             525                 530                 535

 ctg gcc gag ggc gcc ccc atc gac tgg ggc gag gag tac agc aac agc     2282
 Leu Ala Glu Gly Ala Pro Ile Asp Trp Gly Glu Glu Tyr Ser Asn Ser
         540                 545                 550

 ggc ggg ggc ggc agc ccc agc ccc agc acc ccg gag tca gcc acc ctc     2330
 Gly Gly Gly Gly Ser Pro Ser Pro Ser Thr Pro Glu Ser Ala Thr Leu
     555                 560                 565

 tcg gaa aag cga cgg cgc gcc aag cag gtg gtc tct gtg gtc cag gat     2378
 Ser Glu Lys Arg Arg Arg Ala Lys Gln Val Val Ser Val Val Gln Asp
 570                 575                 580                 585

 gag gag gtg ggg ctg ccc ttt gag gct agc cct gag tca cca cca cct     2426
 Glu Glu Val Gly Leu Pro Phe Glu Ala Ser Pro Glu Ser Pro Pro Pro
                 590                 595                 600

 gcg tcc ccg gac ggt gtc act gag atc cga ggc ctg ctg gcc caa ggt     2474
 Ala Ser Pro Asp Gly Val Thr Glu Ile Arg Gly Leu Leu Ala Gln Gly
             605                 610                 615

 ctg cgg cct gag agc ccc cca cca gcc ggc ccc ctg ctc aac ggg gcc     2522
 Leu Arg Pro Glu Ser Pro Pro Pro Ala Gly Pro Leu Leu Asn Gly Ala
         620                 625                 630

 ccc gct ggg gag agt ccc cag cct aag gcc gcc ccc gag gcc tcc tcg     2570
 Pro Ala Gly Glu Ser Pro Gln Pro Lys Ala Ala Pro Glu Ala Ser Ser
     635                 640                 645

 ccg cct gcc tca ccc ctc cag cat ctc ctg cct gga aag gct gtg gac     2618
 Pro Pro Ala Ser Pro Leu Gln His Leu Leu Pro Gly Lys Ala Val Asp
 650                 655                 660                 665

 ctt ggg ccc ccc aag ccc agc gac cag gag act gga gag cag gtg tcc     2666
 Leu Gly Pro Pro Lys Pro Ser Asp Gln Glu Thr Gly Glu Gln Val Ser
                 670                 675                 680

 agc ccc agc agc cac ccc gcc ctc cac acc acc acc gag gac agt gca     2714
 Ser Pro Ser Ser His Pro Ala Leu His Thr Thr Thr Glu Asp Ser Ala
             685                 690                 695

 ggg gtg cag act gag ttc tag gc cagtgggtcc ctgactgctg cacatggcac     2767
 Gly Val Gln Thr Glu Phe 
         700

 aggccgttcc cttccggacc caggcaggct cagctctggg gagggcaccc tggtctgtgc   2827

 cttgtgggtg gaggcggggc agggctgtgt ggcaccgcca gggagcgggc ccacctgagt   2887

 cactttattg ggttcagtca acactttctt gctccctgtt ttctcttctg tgggatgatc   2947

 tcagatgcag gggctggttt tggggttttc ctgcttgtgc caagggctgg acactgctgg   3007

 ggggctggaa agcccctccc ttcctgtcct tctgtggcct ccatcccctc atgggtgctg   3067

 ccatccttcc tggagagagg gaggtgaaag ctggtgtgag cccagtgggt tcccgcccac   3127

 tcacccagga gctggctggg ccaggaccgg gagagggagc actgctgccc tcctggccct   3187

 gctccttccg cagttagggg tggaccgagc ctcgctttcc ccactgttct ggagggaagg   3247

 ggaaggaggg ggtcttcagg ctggagccag gctgggggtg ctgggtggag agatgagatt   3307

 tagggggtgc ctcatggggt gggcaggcct ggggtgaaat gagaaaggcc cagaacgtgc   3367

 aggtctgcgg aggggaagtg tcctgagtga aggaggggac ccccatcctg ggggatgctg   3427

 ggagtgagtg agtgagatgg ctgagtgagg gttatgggga gcctgaggtt ttatgggcct   3487

 gtgtatcccc ttctcccggc cccagcctgc ctccctcctg cccgcctggc ccacaggacg   3547

 tgtggtggcg cctggcactc agggaccccc agctgcccca gccctggtct ctggcgcatc   3607

 tcttccctct tgtcccgaag atctgcgcct ctagtgcctt ttgaggggtt cccatcatcc   3667

 ctccctgata ttgtattgaa aatattatgc acactgttca tgcttctact aatcaataaa   3727

 cgctttattt aaaaaaaaaa aa                                            3749




      <210> 126
      <211> 1649
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (157)..(972)

      <400> 126
 atggctgtgg ccccctgggg ttctctcctg gcctccctgg gtggaagctg tggttcagcc     60

 cgagaacttt tcattcataa aaagaaaaga ctccgcacgg cgcgggtgag tcagaaccca    120

 gcagccgtgt accccgcaga gccgccagcc ccgggc  atg ttc cga gac ttt ggg     174
                                          Met Phe Arg Asp Phe Gly
                                            1               5

 gaa ccc ggc ccg agc tcc ggg aac ggc ggc ggg tac ggc ggc ccc gcg      222
 Glu Pro Gly Pro Ser Ser Gly Asn Gly Gly Gly Tyr Gly Gly Pro Ala
              10                  15                  20

 cag ccc ccg gcc gca gcg cag gca gcc cag cag aag ttc cac ctg gtg      270
 Gln Pro Pro Ala Ala Ala Gln Ala Ala Gln Gln Lys Phe His Leu Val
          25                  30                  35

 cca agc atc aac acc atg agt ggc agt cag gag ctg cag tgg atg gta      318
 Pro Ser Ile Asn Thr Met Ser Gly Ser Gln Glu Leu Gln Trp Met Val
      40                  45                  50

 cag cct cat ttc ctg ggg ccc agc agt tac ccc agg cct ctg acc tac      366
 Gln Pro His Phe Leu Gly Pro Ser Ser Tyr Pro Arg Pro Leu Thr Tyr
  55                  60                  65                  70

 cct cag tac agc ccc cca caa ccc cgg cca gga gtc atc cgg gcc ctg      414
 Pro Gln Tyr Ser Pro Pro Gln Pro Arg Pro Gly Val Ile Arg Ala Leu
                  75                  80                  85

 ggg ccg cct cca ggg gta cgt cga agg cct tgt gaa cag atc agc ccg      462
 Gly Pro Pro Pro Gly Val Arg Arg Arg Pro Cys Glu Gln Ile Ser Pro
              90                  95                 100

 gag gaa gag gag cgc cgc cga gta agg cgc gag cgg aac aag ctg gct      510
 Glu Glu Glu Glu Arg Arg Arg Val Arg Arg Glu Arg Asn Lys Leu Ala
         105                 110                 115

 gcg gcc aag tgc agg aac cgg agg aag gaa ctg acc gac ttc ctg cag      558
 Ala Ala Lys Cys Arg Asn Arg Arg Lys Glu Leu Thr Asp Phe Leu Gln
     120                 125                 130

 gcg gag act gac aaa ctg gaa gat gag aaa tct ggg ctg cag cga gag      606
 Ala Glu Thr Asp Lys Leu Glu Asp Glu Lys Ser Gly Leu Gln Arg Glu
 135                 140                 145                 150

 att gag gag ctg cag aag cag aag gag cgc cta gag ctg gtg ctg gaa      654
 Ile Glu Glu Leu Gln Lys Gln Lys Glu Arg Leu Glu Leu Val Leu Glu
                 155                 160                 165

 gcc cac cga ccc atc tgc aaa atc ccg gaa gga gcc aag gag ggg gac      702
 Ala His Arg Pro Ile Cys Lys Ile Pro Glu Gly Ala Lys Glu Gly Asp
             170                 175                 180

 aca ggc agt acc agt ggc acc agc agc cca cca gcc ccc tgc cgc cct      750
 Thr Gly Ser Thr Ser Gly Thr Ser Ser Pro Pro Ala Pro Cys Arg Pro
         185                 190                 195

 gta cct tgt atc tcc ctt tcc cca ggg cct gtg ctt gaa cct gag gca      798
 Val Pro Cys Ile Ser Leu Ser Pro Gly Pro Val Leu Glu Pro Glu Ala
     200                 205                 210

 ctg cac acc ccc aca ctc atg acc aca ccc tcc cta act cct ttc acc      846
 Leu His Thr Pro Thr Leu Met Thr Thr Pro Ser Leu Thr Pro Phe Thr
 215                 220                 225                 230

 ccc agc ctg gtc ttc acc tac ccc agc act cct gag cct tgt gcc tca      894
 Pro Ser Leu Val Phe Thr Tyr Pro Ser Thr Pro Glu Pro Cys Ala Ser
                 235                 240                 245

 gct cat cgc aag agt agc agc agc agc gga gac cca tcc tct gac ccc      942
 Ala His Arg Lys Ser Ser Ser Ser Ser Gly Asp Pro Ser Ser Asp Pro
             250                 255                 260

 ctt ggc tct cca acc ctc ctc gct ttg tga g gcgcctgagc cctactccct      993
 Leu Gly Ser Pro Thr Leu Leu Ala Leu 
         265                 270

 gcagatgcca ccctagccaa tgtctcctcc ccttccccca ccggtccagc tggcctggac   1053

 agtatcccac atccaactcc agcaacttct tctccatccc tctaatgaga ctgaccatat   1113

 tgtgcttcac agtagagcca gcttggggcc accaaagctg cccactgttt ctcttgagct   1173

 ggcctctcta gcacaatttg cactaaatca gagacaaaat atttcccatt tgtgccagag   1233

 gaatcctggc agcccagaga ctttgtagat ccttagaggt cctctggagc cctaacccct   1293

 tccagatcac tgccacactc tccatcaccc tcttcctgtg atccacccaa ccctatctcc   1353

 tgacagaagg tgccacttta cccacctaga acactaactc accagcccca ctgccagcag   1413

 cagcaggtga ttggaccagg ccattctgcc gccccctcct gaaccgcaca gctcaggagg   1473

 cgcccttggc ttctgtgatg agctgatctg cggatctcag ctttgagaag ccttcagctc   1533

 cagggaatcc aagcctccac agcgagggca gctgctattt attttcctaa agagagtatt   1593

 tttatacaaa cctaccaaaa tggaataaaa ggcttgaagc tgtgaaaaaa aaaaaa       1649




      <210> 127
      <211> 9964
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (217)..(5922)

      <400> 127
 ccggacttcc cgggtcgacg atttcgtgcg ggagggggcc agcttgcttg cccggctcgc     60

 tcacgggtcg ttgaggccgg tgacatgtct gtgagctgcg gaggctgcgg cccccagatc    120

 tttctctttg acactttgca ataaaaaagg gcagtgagat tgaataggtg ttttgtggat    180

 taactcttca ttgattatat acaacaaaaa atagtt  atg gcg act ttc aga aac     234
                                          Met Ala Thr Phe Arg Asn
                                            1               5

 aat cac atg aag act aaa gca tct gtc aga aaa agc ttc agt gaa gat      282
 Asn His Met Lys Thr Lys Ala Ser Val Arg Lys Ser Phe Ser Glu Asp
              10                  15                  20

 gtg ttc cag tct gta aag tct tta ttg cag agt cag aag gaa cta tgc      330
 Val Phe Gln Ser Val Lys Ser Leu Leu Gln Ser Gln Lys Glu Leu Cys
          25                  30                  35

 agt gta aca gca gag gac tgt tta cag cag gat gag cat gcc aat tta      378
 Ser Val Thr Ala Glu Asp Cys Leu Gln Gln Asp Glu His Ala Asn Leu
      40                  45                  50

 act gag gtc aca ttt ctg ggt ttt aat gaa gag aca gat gct gct cat      426
 Thr Glu Val Thr Phe Leu Gly Phe Asn Glu Glu Thr Asp Ala Ala His
  55                  60                  65                  70

 ata cag gat tta gct gca gtt tct ttg gaa ctt cca gat att ctg aat      474
 Ile Gln Asp Leu Ala Ala Val Ser Leu Glu Leu Pro Asp Ile Leu Asn
                  75                  80                  85

 tca ctc cac ttc tgc agt cta aat gaa aat gaa att att tgt atg aag      522
 Ser Leu His Phe Cys Ser Leu Asn Glu Asn Glu Ile Ile Cys Met Lys
              90                  95                 100

 aat ata aat aaa cca tta gat ata agc agt gat cct cta aat cag agt      570
 Asn Ile Asn Lys Pro Leu Asp Ile Ser Ser Asp Pro Leu Asn Gln Ser
         105                 110                 115

 cat cct tct gga atg ctt tgt gtc atg aga gtg tca cct aca tca cca      618
 His Pro Ser Gly Met Leu Cys Val Met Arg Val Ser Pro Thr Ser Pro
     120                 125                 130

 aga ctt agg att gat ttt atc ttt agt ctc cta agt aaa tat gct act      666
 Arg Leu Arg Ile Asp Phe Ile Phe Ser Leu Leu Ser Lys Tyr Ala Thr
 135                 140                 145                 150

 ggt ata agg tac acc ttg gac aca ttc ttg cat cag aag cac caa ctt      714
 Gly Ile Arg Tyr Thr Leu Asp Thr Phe Leu His Gln Lys His Gln Leu
                 155                 160                 165

 gag acc act gat gaa gat gat gat gat act aac cag tct gtg tca tcc      762
 Glu Thr Thr Asp Glu Asp Asp Asp Asp Thr Asn Gln Ser Val Ser Ser
             170                 175                 180

 ata gag gat gac ttt gtc act gct ttt gag cac tta gaa gag gaa gag      810
 Ile Glu Asp Asp Phe Val Thr Ala Phe Glu His Leu Glu Glu Glu Glu
         185                 190                 195

 act tca aag cca tac aat gat gga atg aac att act gtg cta agg agc      858
 Thr Ser Lys Pro Tyr Asn Asp Gly Met Asn Ile Thr Val Leu Arg Ser
     200                 205                 210

 cag tgt gat gct gct tcc cag acg gtt act ggt cat cat tta gaa acc      906
 Gln Cys Asp Ala Ala Ser Gln Thr Val Thr Gly His His Leu Glu Thr
 215                 220                 225                 230

 cat gat tta aag att ctc att agc tct gga cag cag aag tca ttg gct      954
 His Asp Leu Lys Ile Leu Ile Ser Ser Gly Gln Gln Lys Ser Leu Ala
                 235                 240                 245

 aaa ccc tca act tcc tca gtg aat gtc ctg gga cat aaa gaa cta cct     1002
 Lys Pro Ser Thr Ser Ser Val Asn Val Leu Gly His Lys Glu Leu Pro
             250                 255                 260

 tct gtg aaa act tca gtc aca aca tca att tca gag cct tgg acc caa     1050
 Ser Val Lys Thr Ser Val Thr Thr Ser Ile Ser Glu Pro Trp Thr Gln
         265                 270                 275

 agg agt ttc tat agg tca tct aat gct tca gat aaa gat agt gat tta     1098
 Arg Ser Phe Tyr Arg Ser Ser Asn Ala Ser Asp Lys Asp Ser Asp Leu
     280                 285                 290

 cag aaa aca ttt ttt tcg tct tct cct gcc tac tca tct gaa tca gaa     1146
 Gln Lys Thr Phe Phe Ser Ser Ser Pro Ala Tyr Ser Ser Glu Ser Glu
 295                 300                 305                 310

 tgt tca agt cca agt cct gtt att ttc ttg gat gaa gag gga tat caa     1194
 Cys Ser Ser Pro Ser Pro Val Ile Phe Leu Asp Glu Glu Gly Tyr Gln
                 315                 320                 325

 aaa agc tta aaa gca aaa ctt gag ctg cct aaa att cct gtg atg aaa     1242
 Lys Ser Leu Lys Ala Lys Leu Glu Leu Pro Lys Ile Pro Val Met Lys
             330                 335                 340

 gat gat ata gag gat tca gac tca gaa gta agt gaa ttt ttt gat agt     1290
 Asp Asp Ile Glu Asp Ser Asp Ser Glu Val Ser Glu Phe Phe Asp Ser
         345                 350                 355

 ttt gat cag ttt gat gaa cta gaa caa act tta gag act tgc ctg ttt     1338
 Phe Asp Gln Phe Asp Glu Leu Glu Gln Thr Leu Glu Thr Cys Leu Phe
     360                 365                 370

 aac aaa gat ccc gtc ata ggg aag tca tcg cag agg aaa ggg cac aaa     1386
 Asn Lys Asp Pro Val Ile Gly Lys Ser Ser Gln Arg Lys Gly His Lys
 375                 380                 385                 390

 cat gga aag tca tgt atg aat cct caa aaa ttc aag ttt gat cgt cca     1434
 His Gly Lys Ser Cys Met Asn Pro Gln Lys Phe Lys Phe Asp Arg Pro
                 395                 400                 405

 gct ctc cca gct aat gtt aga aag cca act cct cgt aaa cca gaa tct     1482
 Ala Leu Pro Ala Asn Val Arg Lys Pro Thr Pro Arg Lys Pro Glu Ser
             410                 415                 420

 cca tat ggt aac ctg tgt gat gct ccg gat tct cct cgc cca gtg aag     1530
 Pro Tyr Gly Asn Leu Cys Asp Ala Pro Asp Ser Pro Arg Pro Val Lys
         425                 430                 435

 gca tca agg gaa gat agt ggt tta ttt agt cct att cga tcc tct gct     1578
 Ala Ser Arg Glu Asp Ser Gly Leu Phe Ser Pro Ile Arg Ser Ser Ala
     440                 445                 450

 ttt agt cct ctt gga ggc tgt act cca gct gaa tgt ttt tgc caa aca     1626
 Phe Ser Pro Leu Gly Gly Cys Thr Pro Ala Glu Cys Phe Cys Gln Thr
 455                 460                 465                 470

 gat att ggt gga gat agg att cat gaa aat cat gat tct gtt tat tac     1674
 Asp Ile Gly Gly Asp Arg Ile His Glu Asn His Asp Ser Val Tyr Tyr
                 475                 480                 485

 acc tat gaa gac tat gca aaa agc att tca tgt gaa gta cta ggc tca     1722
 Thr Tyr Glu Asp Tyr Ala Lys Ser Ile Ser Cys Glu Val Leu Gly Ser
             490                 495                 500

 gtt ctt cgt acc cac cat act aat acc cta tca aat att aac agt att     1770
 Val Leu Arg Thr His His Thr Asn Thr Leu Ser Asn Ile Asn Ser Ile
         505                 510                 515

 aaa cat gga gaa aat aaa act gta act ttt aag cat gga aac ctt gat     1818
 Lys His Gly Glu Asn Lys Thr Val Thr Phe Lys His Gly Asn Leu Asp
     520                 525                 530

 caa aaa aat aaa tct aaa aat aaa tcc tta atg att aaa aat agc att     1866
 Gln Lys Asn Lys Ser Lys Asn Lys Ser Leu Met Ile Lys Asn Ser Ile
 535                 540                 545                 550

 caa aaa ttt gca gca gat ctt gtg gaa aaa agt ttt ggc agt gca ttt     1914
 Gln Lys Phe Ala Ala Asp Leu Val Glu Lys Ser Phe Gly Ser Ala Phe
                 555                 560                 565

 aaa gac tta cag aaa gga gtc tct tca tgt acc aat gct ttg tac cac     1962
 Lys Asp Leu Gln Lys Gly Val Ser Ser Cys Thr Asn Ala Leu Tyr His
             570                 575                 580

 tta gcc atc aaa ttg aca tca tct gtt ttg cag atg gca ttt gat gag     2010
 Leu Ala Ile Lys Leu Thr Ser Ser Val Leu Gln Met Ala Phe Asp Glu
         585                 590                 595

 ctg aga agg cag cgt gca ttt tca cta aaa gaa cgt gcc att agt ggc     2058
 Leu Arg Arg Gln Arg Ala Phe Ser Leu Lys Glu Arg Ala Ile Ser Gly
     600                 605                 610

 ctg gct aac ttt ttg gtg agt gaa gct tta tca aat gcc tta aaa gat     2106
 Leu Ala Asn Phe Leu Val Ser Glu Ala Leu Ser Asn Ala Leu Lys Asp
 615                 620                 625                 630

 tta cag tat gta aag aag cag ata ttc aca aac aca gtt gct agg ttt     2154
 Leu Gln Tyr Val Lys Lys Gln Ile Phe Thr Asn Thr Val Ala Arg Phe
                 635                 640                 645

 gct gca gat ctt gct gaa gag ctt gtt ttt gaa ggc atc atg gag gtg     2202
 Ala Ala Asp Leu Ala Glu Glu Leu Val Phe Glu Gly Ile Met Glu Val
             650                 655                 660

 tgt cag ttt tca tat cct caa acg cct gca tct cca cag tgt ggg tcg     2250
 Cys Gln Phe Ser Tyr Pro Gln Thr Pro Ala Ser Pro Gln Cys Gly Ser
         665                 670                 675

 ttt gac ttt gaa gac aaa gta gtg aag ttg tat gca aaa gat ttg tct     2298
 Phe Asp Phe Glu Asp Lys Val Val Lys Leu Tyr Ala Lys Asp Leu Ser
     680                 685                 690

 gaa tct gta ata cag gaa gca ttc att gag cta tca caa gtt gat gtg     2346
 Glu Ser Val Ile Gln Glu Ala Phe Ile Glu Leu Ser Gln Val Asp Val
 695                 700                 705                 710

 acc ttt aca aca aag gca gca gtt agt gtc tct acg gat aat atc aag     2394
 Thr Phe Thr Thr Lys Ala Ala Val Ser Val Ser Thr Asp Asn Ile Lys
                 715                 720                 725

 tat gtg agt gca gaa agt gta gtg cca tcg aca cag gct gtc acg ttt     2442
 Tyr Val Ser Ala Glu Ser Val Val Pro Ser Thr Gln Ala Val Thr Phe
             730                 735                 740

 tcc cct tct ttt cac aat caa gca att atg gtg aca aaa cca gtg cag     2490
 Ser Pro Ser Phe His Asn Gln Ala Ile Met Val Thr Lys Pro Val Gln
         745                 750                 755

 gaa tat aaa aag gaa tac aca gtg cag cag gcc ttg ttt tgt act tct     2538
 Glu Tyr Lys Lys Glu Tyr Thr Val Gln Gln Ala Leu Phe Cys Thr Ser
     760                 765                 770

 gga att gtt act tct ata ccg gtg ccc ttg gca gga agt gcc ctt ctc     2586
 Gly Ile Val Thr Ser Ile Pro Val Pro Leu Ala Gly Ser Ala Leu Leu
 775                 780                 785                 790

 cca tat cat att tca tct act gca tgt cag gcc aag gct cat ctg tca     2634
 Pro Tyr His Ile Ser Ser Thr Ala Cys Gln Ala Lys Ala His Leu Ser
                 795                 800                 805

 tct gat gat agt aat tca aat ggt gat tct gcc caa gtg cat att gcc     2682
 Ser Asp Asp Ser Asn Ser Asn Gly Asp Ser Ala Gln Val His Ile Ala
             810                 815                 820

 aca aaa aac aga gaa gaa aaa gca gct tgt ctc aga aat att tgt tta     2730
 Thr Lys Asn Arg Glu Glu Lys Ala Ala Cys Leu Arg Asn Ile Cys Leu
         825                 830                 835

 cct tca gaa cac aat cca ggt aat cag aat gat ttt aaa cca act aat     2778
 Pro Ser Glu His Asn Pro Gly Asn Gln Asn Asp Phe Lys Pro Thr Asn
     840                 845                 850

 gac gat att gaa atg cag agt tcc tca aaa tta cca aat gat cct gca     2826
 Asp Asp Ile Glu Met Gln Ser Ser Ser Lys Leu Pro Asn Asp Pro Ala
 855                 860                 865                 870

 att att agc aac ttt tct gca gca gtg gtg cat acg ata gta aat gaa     2874
 Ile Ile Ser Asn Phe Ser Ala Ala Val Val His Thr Ile Val Asn Glu
                 875                 880                 885

 act tta gag tca atg aca tca ttg gaa gtt aca aaa atg gtt gat gaa     2922
 Thr Leu Glu Ser Met Thr Ser Leu Glu Val Thr Lys Met Val Asp Glu
             890                 895                 900

 cgt aca gat tat tta act aaa tct tta aag gag aaa acc cct cca ttt     2970
 Arg Thr Asp Tyr Leu Thr Lys Ser Leu Lys Glu Lys Thr Pro Pro Phe
         905                 910                 915

 tcc cac tgt gat cag gca gtg ctg caa tgc agt gaa gct agt agc aat     3018
 Ser His Cys Asp Gln Ala Val Leu Gln Cys Ser Glu Ala Ser Ser Asn
     920                 925                 930

 aag gac atg ttt gct gac cgg tta tct aaa tct att att aaa cat tcc     3066
 Lys Asp Met Phe Ala Asp Arg Leu Ser Lys Ser Ile Ile Lys His Ser
 935                 940                 945                 950

 ata gat aag agc aaa tca gtg atc cca aat ata gat aaa aat gca gta     3114
 Ile Asp Lys Ser Lys Ser Val Ile Pro Asn Ile Asp Lys Asn Ala Val
                 955                 960                 965

 tac aag gaa agc ttg cct gtt tct gga gaa gaa tca cag ttg aca cca     3162
 Tyr Lys Glu Ser Leu Pro Val Ser Gly Glu Glu Ser Gln Leu Thr Pro
             970                 975                 980

 gaa aag tct ccc aaa ttt cct gac tct cag aat cag tta act cac tgc     3210
 Glu Lys Ser Pro Lys Phe Pro Asp Ser Gln Asn Gln Leu Thr His Cys
         985                 990                 995

 tca ctt tca gct gca aag gat tgt gtt cca gaa tgt aaa gtt tct atg     3258
 Ser Leu Ser Ala Ala Lys Asp Cys Val Pro Glu Cys Lys Val Ser Met
    1000                1005                1010

 gtt cat gga tcc tcc cta gag aca ctg cca tct tgt cca gct gtg aca     3306
 Val His Gly Ser Ser Leu Glu Thr Leu Pro Ser Cys Pro Ala Val Thr
1015                1020                1025                1030

 ggt cag aaa tct gac ttg aag gaa tct gct aag gat caa cca ctg aaa     3354
 Gly Gln Lys Ser Asp Leu Lys Glu Ser Ala Lys Asp Gln Pro Leu Lys
                1035                1040                1045

 aag cat aac ttg aat agt aca tca ctt gag gcc ttg tct ttt gga cgg     3402
 Lys His Asn Leu Asn Ser Thr Ser Leu Glu Ala Leu Ser Phe Gly Arg
            1050                1055                1060

 gaa aac ccc ttt cct cat tca cat act ttc tca tct aca gca ctt acc     3450
 Glu Asn Pro Phe Pro His Ser His Thr Phe Ser Ser Thr Ala Leu Thr
        1065                1070                1075

 tgt gta gat ggt ttg cat gtg gaa gat aaa cag aaa gtc aga gac aga     3498
 Cys Val Asp Gly Leu His Val Glu Asp Lys Gln Lys Val Arg Asp Arg
    1080                1085                1090

 aat gta ata cct gat act cct cca tca act cct cta gta cca tcc cgg     3546
 Asn Val Ile Pro Asp Thr Pro Pro Ser Thr Pro Leu Val Pro Ser Arg
1095                1100                1105                1110

 gct agt tct gaa tgg gat atc aag aag tta act aaa aag ctc aag gga     3594
 Ala Ser Ser Glu Trp Asp Ile Lys Lys Leu Thr Lys Lys Leu Lys Gly
                1115                1120                1125

 gaa tta gcc aaa gag ttt gca cct gct aca cca cct tct act cca cac     3642
 Glu Leu Ala Lys Glu Phe Ala Pro Ala Thr Pro Pro Ser Thr Pro His
            1130                1135                1140

 aac tca tct gtt ggt agt ttg tct gag aat gaa caa aat act ata gaa     3690
 Asn Ser Ser Val Gly Ser Leu Ser Glu Asn Glu Gln Asn Thr Ile Glu
        1145                1150                1155

 aaa gaa gag ttc atg ttg aaa ctc atg cga tct ctt tct gaa gaa gtt     3738
 Lys Glu Glu Phe Met Leu Lys Leu Met Arg Ser Leu Ser Glu Glu Val
    1160                1165                1170

 gag agt agt gaa agt gga gag ctc cca gaa gtg gat gtg aag tcg gag     3786
 Glu Ser Ser Glu Ser Gly Glu Leu Pro Glu Val Asp Val Lys Ser Glu
1175                1180                1185                1190

 cac tca ggg aag aag gtt cag ttt gca gaa gca tta gct aca cac atc     3834
 His Ser Gly Lys Lys Val Gln Phe Ala Glu Ala Leu Ala Thr His Ile
                1195                1200                1205

 ctt tct ctt gca act gaa atg gca gct tcc cat tta gat aac aaa ata     3882
 Leu Ser Leu Ala Thr Glu Met Ala Ala Ser His Leu Asp Asn Lys Ile
            1210                1215                1220

 att caa gaa ccc aag gtt aaa aac cct tgc tta aat gtg caa agt caa     3930
 Ile Gln Glu Pro Lys Val Lys Asn Pro Cys Leu Asn Val Gln Ser Gln
        1225                1230                1235

 aga agt gtg tcg cct act ttt tta aac ccc tca gac gaa aat ttg aaa     3978
 Arg Ser Val Ser Pro Thr Phe Leu Asn Pro Ser Asp Glu Asn Leu Lys
    1240                1245                1250

 aca tta tgc aat ttt gcg ggt gat ctg gca gca gaa gtc att aca gaa     4026
 Thr Leu Cys Asn Phe Ala Gly Asp Leu Ala Ala Glu Val Ile Thr Glu
1255                1260                1265                1270

 gct gag aaa ata gca aaa gtc cga aat tgt atg ctt ttc aag caa aag     4074
 Ala Glu Lys Ile Ala Lys Val Arg Asn Cys Met Leu Phe Lys Gln Lys
                1275                1280                1285

 aag aac agt tgt tat gct gat ggt gac gaa gat tat aaa gta gaa gag     4122
 Lys Asn Ser Cys Tyr Ala Asp Gly Asp Glu Asp Tyr Lys Val Glu Glu
            1290                1295                1300

 aag ttg gat ata gag gct gta gtg cac cca aga gaa gtg gat ccg ttt     4170
 Lys Leu Asp Ile Glu Ala Val Val His Pro Arg Glu Val Asp Pro Phe
        1305                1310                1315

 att ctt tca tta cca cca agt tct tgt atg tca ggt ctg atg tat aag     4218
 Ile Leu Ser Leu Pro Pro Ser Ser Cys Met Ser Gly Leu Met Tyr Lys
    1320                1325                1330

 tat ccc agc tgt gaa agt gtg aca gat gaa tat gca ggt cac ctt att     4266
 Tyr Pro Ser Cys Glu Ser Val Thr Asp Glu Tyr Ala Gly His Leu Ile
1335                1340                1345                1350

 cag ata cta aaa cag gaa ggt ggt aat agt gag ttg ata atg gat cag     4314
 Gln Ile Leu Lys Gln Glu Gly Gly Asn Ser Glu Leu Ile Met Asp Gln
                1355                1360                1365

 tat gcc aat agg ctt gcc tac cga tct gtt aaa tca gga tta cag gaa     4362
 Tyr Ala Asn Arg Leu Ala Tyr Arg Ser Val Lys Ser Gly Leu Gln Glu
            1370                1375                1380

 gca gct aag aca acc aaa gtg cag tgc aac tca aga atg ttc cct gtg     4410
 Ala Ala Lys Thr Thr Lys Val Gln Cys Asn Ser Arg Met Phe Pro Val
        1385                1390                1395

 cca agt tca caa gtg aaa aca aac aag gaa ctg tta atg ttt tca aac     4458
 Pro Ser Ser Gln Val Lys Thr Asn Lys Glu Leu Leu Met Phe Ser Asn
    1400                1405                1410

 aaa gag cac cac caa gaa gca gac aaa aag aga caa agt aaa aga aat     4506
 Lys Glu His His Gln Glu Ala Asp Lys Lys Arg Gln Ser Lys Arg Asn
1415                1420                1425                1430

 gaa ggt tac ttt tgt aaa aat caa act tgt gaa agg acc ctg gat cca     4554
 Glu Gly Tyr Phe Cys Lys Asn Gln Thr Cys Glu Arg Thr Leu Asp Pro
                1435                1440                1445

 tat aga aat gag gtc tcc caa ctg tat agt ttt tca acc tct ctc gtt     4602
 Tyr Arg Asn Glu Val Ser Gln Leu Tyr Ser Phe Ser Thr Ser Leu Val
            1450                1455                1460

 cac agc ata aca aaa gat gct aag gaa gag ttg aca gcc tct cta gtt     4650
 His Ser Ile Thr Lys Asp Ala Lys Glu Glu Leu Thr Ala Ser Leu Val
        1465                1470                1475

 ggc cta cca aaa tcc tta aca gat tct tgc ttg ttt gaa aaa tct gga     4698
 Gly Leu Pro Lys Ser Leu Thr Asp Ser Cys Leu Phe Glu Lys Ser Gly
    1480                1485                1490

 tat gaa gaa gat aat gag tgt cac gtt aca cca gaa ttg cct aag tct     4746
 Tyr Glu Glu Asp Asn Glu Cys His Val Thr Pro Glu Leu Pro Lys Ser
1495                1500                1505                1510

 ctt cag cct tcc tca caa aat cac agg ttt tac cac agc act ggc agt     4794
 Leu Gln Pro Ser Ser Gln Asn His Arg Phe Tyr His Ser Thr Gly Ser
                1515                1520                1525

 tta aat gga tat ggt tgt gga gac aat gtt gtt caa gct gta gaa cag     4842
 Leu Asn Gly Tyr Gly Cys Gly Asp Asn Val Val Gln Ala Val Glu Gln
            1530                1535                1540

 tat gcc aaa aaa gta gtg gat gac act cta gag cta act cta gga tct     4890
 Tyr Ala Lys Lys Val Val Asp Asp Thr Leu Glu Leu Thr Leu Gly Ser
        1545                1550                1555

 aca gtg ttc cga gtg tct gag acc aca aaa tca gca gac agg gtc act     4938
 Thr Val Phe Arg Val Ser Glu Thr Thr Lys Ser Ala Asp Arg Val Thr
    1560                1565                1570

 tat gca gaa aag ttg tca cct ctt aca ggt caa gct tgc aga tac tgt     4986
 Tyr Ala Glu Lys Leu Ser Pro Leu Thr Gly Gln Ala Cys Arg Tyr Cys
1575                1580                1585                1590

 gac ctt aaa gaa ctc cac aat tgc act gga aat tca tct cag cac ttt     5034
 Asp Leu Lys Glu Leu His Asn Cys Thr Gly Asn Ser Ser Gln His Phe
                1595                1600                1605

 ttc aga cag ggt tct ctc gcc agt agt aag cca gct tct aat cca aaa     5082
 Phe Arg Gln Gly Ser Leu Ala Ser Ser Lys Pro Ala Ser Asn Pro Lys
            1610                1615                1620

 ttt agc agc cgc tat cag aaa tct agg att ttt cat ctc agt gtc cct     5130
 Phe Ser Ser Arg Tyr Gln Lys Ser Arg Ile Phe His Leu Ser Val Pro
        1625                1630                1635

 cag att cat gtt aat ctt gat aag aag gca gtg ctt gct gag aag ata     5178
 Gln Ile His Val Asn Leu Asp Lys Lys Ala Val Leu Ala Glu Lys Ile
    1640                1645                1650

 gtt gct gaa gcc att gaa aaa gct gag cga gag ctg agc agt acc agc     5226
 Val Ala Glu Ala Ile Glu Lys Ala Glu Arg Glu Leu Ser Ser Thr Ser
1655                1660                1665                1670

 ctg gca gcc gac agt ggg atc gga cag gag ggt gcc agc ttt gct gaa     5274
 Leu Ala Ala Asp Ser Gly Ile Gly Gln Glu Gly Ala Ser Phe Ala Glu
                1675                1680                1685

 agc ctt gcc aca gaa acc atg aca gca gct gtc aca aat gtt ggg cat     5322
 Ser Leu Ala Thr Glu Thr Met Thr Ala Ala Val Thr Asn Val Gly His
            1690                1695                1700

 gct gtt agc agt tca aaa gaa ata gaa gac ttt cag tca acc gag tct     5370
 Ala Val Ser Ser Ser Lys Glu Ile Glu Asp Phe Gln Ser Thr Glu Ser
        1705                1710                1715

 gtc agt agc cag cag atg aac ctc agt att ggt gat gac agc act ggt     5418
 Val Ser Ser Gln Gln Met Asn Leu Ser Ile Gly Asp Asp Ser Thr Gly
    1720                1725                1730

 agc tgg tcc aat tta agt ttt gaa gat gaa cac caa gat gaa agc agc     5466
 Ser Trp Ser Asn Leu Ser Phe Glu Asp Glu His Gln Asp Glu Ser Ser
1735                1740                1745                1750

 agt ttt cat cat cta agt gaa agt aat ggt aac agc agt agc tgg agc     5514
 Ser Phe His His Leu Ser Glu Ser Asn Gly Asn Ser Ser Ser Trp Ser
                1755                1760                1765

 agt ctt ggt tta gaa gga gat ttg tat gag gac aat tta tcc ttt cca     5562
 Ser Leu Gly Leu Glu Gly Asp Leu Tyr Glu Asp Asn Leu Ser Phe Pro
            1770                1775                1780

 aca tca gac agt gat gga cca gat gat aaa gat gaa gag cat gag gac     5610
 Thr Ser Asp Ser Asp Gly Pro Asp Asp Lys Asp Glu Glu His Glu Asp
        1785                1790                1795

 gaa gta gaa ggt ttg ggg caa gat gga aag aca ctg cta att acg aat     5658
 Glu Val Glu Gly Leu Gly Gln Asp Gly Lys Thr Leu Leu Ile Thr Asn
    1800                1805                1810

 att gac atg gag cca tgc acg gta gac ccc cag cta agg att att ctt     5706
 Ile Asp Met Glu Pro Cys Thr Val Asp Pro Gln Leu Arg Ile Ile Leu
1815                1820                1825                1830

 cag tgg ctc att gcc tct gag gct gaa gtt gca gaa ctt tat ttt cat     5754
 Gln Trp Leu Ile Ala Ser Glu Ala Glu Val Ala Glu Leu Tyr Phe His
                1835                1840                1845

 gac tct gca aat aag gag ttt atg cta ctt tca aaa caa tta caa gag     5802
 Asp Ser Ala Asn Lys Glu Phe Met Leu Leu Ser Lys Gln Leu Gln Glu
            1850                1855                1860

 aaa gga tgg aaa gtg gga gac ctc ctg cag gct gtg ctt caa tac tat     5850
 Lys Gly Trp Lys Val Gly Asp Leu Leu Gln Ala Val Leu Gln Tyr Tyr
        1865                1870                1875

 gaa gtg atg gaa aaa gct tcc agt gag gag aga tgc aag tcg ctg ttt     5898
 Glu Val Met Glu Lys Ala Ser Ser Glu Glu Arg Cys Lys Ser Leu Phe
    1880                1885                1890

 gat tgg ctc ttg gaa aat gca tag agcaaacccc aaaccagtat attttagtat    5952
 Asp Trp Leu Leu Glu Asn Ala 
1895                1900

 ttgtttgggg aggggaacaa gccaataaag atgtttagga taaaatttga atagtgaata   6012

 ttaacatcgt aagtcagttg ggaggcaagt aaatatagct ttctgagcgc tttgtgttat   6072

 cactcggtgt atatagttca tacttttgta atctgtcaaa atactacctt catttattct   6132

 tctatacaca tgtgtagtgt gtcaagaccc taagaacatg tatttgaagg aaggtctaac   6192

 cagggggttt tcaggggcat tgtctgacca cattcttttt gtatccaaat agtgctgcta   6252

 gaaactgcac tgaagtggct gaggataggt tccagtgata gagttataat tttgctcctt   6312

 tgcaaacaaa tggtatctaa ttaataacta gtctgacatc agaaaataaa attgaggctg   6372

 atttttaaaa atttctagta gatttttggc ctttctttcc tgtttttaaa aatcagtttc   6432

 attttcatat ttcatagatc agctattggt agctttttga tttccccaaa ctatttaatt   6492

 tcttagcaga aacattagta ttttaggttt ctataaacac tataagtgat agtttccccc   6552

 atcctttcat tgacattatt tgccaatgct gccagtcatt ctggcatgaa aggtgtgtgt   6612

 gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtaaggga gtactttaac   6672

 cttgccagtt tgttccctct tttattttac tgttttcttt ttagaaaccc actgttaaaa   6732

 tttaaaaagg tgctttaaaa taaaacgcct ataaagattg tgcagtaaga atttttattg   6792

 acaataatta aaattttttt tgacaatttt gggttcccaa cttatcttac aagtgaaaac   6852

 ttaaattgta aaacatgttg aaattttaaa aattaatgtt aatatggaaa tgcatttaga   6912

 gaagcccagt agtttttatt gttggatttt tgaaaaaacc tctaccaaga atgtggtgtt   6972

 tttttttttt gtttgtttgt tcgttttaga aaaattggga tttcccccca ccccgcccca   7032

 cccagataaa ctatatctac actgtctcgt caagttctct gacacgatct ttctgggctc   7092

 tacatttcct actagtttgt gtccagaaac tgcaagttga catgaataga ggacaaaggt   7152

 tgtgtcttgc ttttgtctct ctcttccctc cctgcaactc tctctcccct cctcccactc   7212

 tcttccccct cccccctcct cccactgtct ctcacctccc ccacccccca ctctctctca   7272

 tctctcgctg tgtcctgtgt atgtgtgggt gtgtgtgtat ttgggtgtgt aaatgttggt   7332

 tcttccacta ctggattttg taatctagga taaatcactt tttttgggga ctttgatttt   7392

 gctccattac gttttcattt tttctgagca ctgactgttc tgaaagctgc acaaaacgta   7452

 gaaagaagac atagcgcctg ccagggaata ggaaatgagg gcacttacac attaatgtga   7512

 attagtaatt gtggtataga aatgttttat agtgaaagat tcaaatttgc ttttcaaaaa   7572

 atgccaaaag ctatttaaat aattcgaggt tacatcgtag gttttgattt ttctcaattt   7632

 aagatacaga aatacagcaa gccttaatat aaagtttcct aaagtttctt caagtatttt   7692

 ttaaggtgga gaaatgcagg aattgtataa ccagaattgt tcctgccttt agcttttcag   7752

 aacttgagat gtggcagcac tggactgggt ttttttaaat gttaggacta ggaatgtttg   7812

 ctcttgttaa ttatgaatta attgattatt aagtttagaa tgcattttta caagtatcta   7872

 actatcaaat tgtgtttagt aacttgagtg tatgcacaag tttgatcaac agcaaaatag   7932

 agttctgaat ttcttttaaa gtgatgatat attattttgt gaaactttgt gtttgaaaat   7992

 gtttatttct gtttatggtg taatcattct gaggtgaggc ttttcttatt tcctttgcat   8052

 tttgctagag ctgtgctgag ttcagcattt gcttatttaa ccactacata atgacagacc   8112

 agttattagg tattagcatg tgtggtaata ataatagtgg aacttcacac ttacatcaat   8172

 tcagtgcagg ggcatagaat aaaatattaa atattggcag atgtatgaaa agaagtgtga   8232

 gttaaaaata ttgaatattg gcaggtgtga aaacaagtgt caaaattcct catatagaga   8292

 aaataatttt gagtttagag tattatcttt taattaagtg tagtctaaac ttaactttct   8352

 gtaaaggcac tttgtggttt ttccaaagat gttctagatc tatttggttg ctctatagtc   8412

 aaacagctct tttgaagaca actgtcttat tttattacaa attggcttga catatttata   8472

 ctgtaacatt gtaatattgc tgtgctgtac attttggccc ttacgaaata cgtctttttc   8532

 agaactgtta aagttttgat gtacatcgag ctgaattctg tttttaccag tttcaaaacc   8592

 ttcaagtgat atgtggaaaa aagtgaatga gacctctgat agggggtttt cagaaccttg   8652

 ttcacaccaa aatgtgacag ttctttcatg ttttcctaaa ccaagttaaa attacatgta   8712

 tattttggtg ttaaggttga tttttaagat acttctgatt tgtacaaaag gaatgtttcc   8772

 tttataaatc acagaagaaa atgacaatat ctgttggata tttgatataa tttaatggtg   8832

 ttataaaacc tttaagagga ttcatggtga atatatgtga taacatcttt atactttgaa   8892

 aaatgttcca cttacccttc agatatttgt tgtaagttaa ttcaattctt aatactttaa   8952

 ttttgctcca acaagggctt tatgttgctg gtaagagaat ttatttacta aatgcactat   9012

 gtataaagtg aaagatagtt tacttatctg actttgatat tagatggctg acattagtgc   9072

 acataatgca gagtttaacc ttgattcttc aacagagtcc agatttaaat gtctacttag   9132

 ttaattagtt agctgatatt cttccacaat taatatattc aatttcccat cagtatatca   9192

 ctttaaattt tatgtttttc taaggaaact ttccacagaa ttttaaacaa ctgatgcatc   9252

 catactcagg gtgtagggag aatactttgc atttaaaaac cctgtccacc tgtcaccagc   9312

 acaagagaat tagagcttca gtgagaattt agaaaaatta tactaaagtg agatgcattt   9372

 tttctcattt tcagcaagac tcctctaagc atttactcat ttactgtatt cctgctctga   9432

 agatgtggat acagaattag tcactcttgt cactttattt atttattggt ttttttttaa   9492

 ccatctgtgt acattccttt catagggtag agttctagtt ctagaagttc ttattttgtt   9552

 tttgttgtaa tgtttgaata ctatttaata tccggtttta atattgctgg atttgctacc   9612

 tttggttact tgtgcagtgt taaaagtaat ccactttctt gtttaatata ccagatacat   9672

 agcaaaagca gcttggaata attatagctg tttatttggc tgtgctcagt tactatatta   9732

 agatcttgta ctgtgtaaca gtaactcttt tttgcttttc agtaatttaa tatgttcact   9792

 taacaaaata cgaactttga gatgcactaa agttttgttt cagcagtggc tcaaaaaatt   9852

 tcagaaatta cttttgtaat tatttgcaat taattgttct tttatcttac aattgtttaa   9912

 gcctgtgatc tttcttctcc cagctaagag ttcttcaata aatttaagaa at           9964




      <210> 128
      <211> 2136
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (31)..(1992)

      <400> 128
 taatagtcac atgacacgtt tcccgtcaag     atg gcg gat act ctc cct tcg      51
                                      Met Ala Asp Thr Leu Pro Ser
                                        1               5

 gag ttt gat gtg atc gta ata ggg acg ggt ttg cct gaa tcc atc att       99
 Glu Phe Asp Val Ile Val Ile Gly Thr Gly Leu Pro Glu Ser Ile Ile
          10                  15                  20

 gca gct gca tgt tca aga agt ggc cgg aga gtt ctg cat gtt gat tca      147
 Ala Ala Ala Cys Ser Arg Ser Gly Arg Arg Val Leu His Val Asp Ser
      25                  30                  35

 aga agc tac tat gga gga aac tgg gcc agt ttt agc ttt tca gga cta      195
 Arg Ser Tyr Tyr Gly Gly Asn Trp Ala Ser Phe Ser Phe Ser Gly Leu
  40                  45                  50                  55

 ttg tcc tgg cta aag gaa tac cag gaa aac agt gac att gta agt gac      243
 Leu Ser Trp Leu Lys Glu Tyr Gln Glu Asn Ser Asp Ile Val Ser Asp
                  60                  65                  70

 agt cca gtg tgg caa gac cag atc ctt gaa aat gaa gaa gcc att gct      291
 Ser Pro Val Trp Gln Asp Gln Ile Leu Glu Asn Glu Glu Ala Ile Ala
              75                  80                  85

 ctt agc agg aag gac aaa act att caa cat gtg gaa gta ttt tgt tat      339
 Leu Ser Arg Lys Asp Lys Thr Ile Gln His Val Glu Val Phe Cys Tyr
          90                  95                 100

 gcc agt cag gat ttg cat gaa gat gtc gaa gaa gct ggt gca ctg cag      387
 Ala Ser Gln Asp Leu His Glu Asp Val Glu Glu Ala Gly Ala Leu Gln
     105                 110                 115

 aaa aat cat gct ctt gtg aca tct gca aac tcc aca gaa gct gca gat      435
 Lys Asn His Ala Leu Val Thr Ser Ala Asn Ser Thr Glu Ala Ala Asp
 120                 125                 130                 135

 tct gcc ttc ctg cct acg gag gat gag tca tta agc act atg agc tgt      483
 Ser Ala Phe Leu Pro Thr Glu Asp Glu Ser Leu Ser Thr Met Ser Cys
                 140                 145                 150

 gaa atg ctc aca gaa caa act cca agc agc gat cca gag aat gcg cta      531
 Glu Met Leu Thr Glu Gln Thr Pro Ser Ser Asp Pro Glu Asn Ala Leu
             155                 160                 165

 gaa gta aat ggt gct gaa gtg aca ggg gaa aaa gaa aac cat tgt gat      579
 Glu Val Asn Gly Ala Glu Val Thr Gly Glu Lys Glu Asn His Cys Asp
         170                 175                 180

 gat aaa act tgt gtg cca tca act tca gca gaa gac atg agt gaa aat      627
 Asp Lys Thr Cys Val Pro Ser Thr Ser Ala Glu Asp Met Ser Glu Asn
     185                 190                 195

 gtg cct ata gca gaa gat acc aca gag caa cca aag aaa aac aga att      675
 Val Pro Ile Ala Glu Asp Thr Thr Glu Gln Pro Lys Lys Asn Arg Ile
 200                 205                 210                 215

 act tac tca caa att att aaa gaa ggc agg aga ttt aat att gat tta      723
 Thr Tyr Ser Gln Ile Ile Lys Glu Gly Arg Arg Phe Asn Ile Asp Leu
                 220                 225                 230

 gta tca aag ctg ctg tat tct cga gga tta cta att gat ctt cta atc      771
 Val Ser Lys Leu Leu Tyr Ser Arg Gly Leu Leu Ile Asp Leu Leu Ile
             235                 240                 245

 aaa tct aat gtt agt cga tat gca gag ttt aaa aat att acc agg att      819
 Lys Ser Asn Val Ser Arg Tyr Ala Glu Phe Lys Asn Ile Thr Arg Ile
         250                 255                 260

 ctt gca ttt cga gaa gga cga gtg gaa cag gtt ccg tgt tcc aga gca      867
 Leu Ala Phe Arg Glu Gly Arg Val Glu Gln Val Pro Cys Ser Arg Ala
     265                 270                 275

 gat gtc ttt aat agc aaa caa ctt act atg gta gaa aag cga atg cta      915
 Asp Val Phe Asn Ser Lys Gln Leu Thr Met Val Glu Lys Arg Met Leu
 280                 285                 290                 295

 atg aaa ttt ctt aca ttt tgt atg gaa tat gag aaa tat cct gat gaa      963
 Met Lys Phe Leu Thr Phe Cys Met Glu Tyr Glu Lys Tyr Pro Asp Glu
                 300                 305                 310

 tat aaa gga tat gaa gag atc aca ttt tat gaa tat tta aag act caa     1011
 Tyr Lys Gly Tyr Glu Glu Ile Thr Phe Tyr Glu Tyr Leu Lys Thr Gln
             315                 320                 325

 aaa tta acc ccc aac ctc caa tat att gtc atg cat tca att gca atg     1059
 Lys Leu Thr Pro Asn Leu Gln Tyr Ile Val Met His Ser Ile Ala Met
         330                 335                 340

 aca tca gag aca gcc agc agc acc ata gat ggt ctc aaa gct acc aaa     1107
 Thr Ser Glu Thr Ala Ser Ser Thr Ile Asp Gly Leu Lys Ala Thr Lys
     345                 350                 355

 aac ttt ctt cac tgt ctt ggg cgg tat ggc aac act cca ttt ttg ttt     1155
 Asn Phe Leu His Cys Leu Gly Arg Tyr Gly Asn Thr Pro Phe Leu Phe
 360                 365                 370                 375

 cct tta tat ggc caa gga gaa ctc ccc cag tgt ttc tgc agg atg tgt     1203
 Pro Leu Tyr Gly Gln Gly Glu Leu Pro Gln Cys Phe Cys Arg Met Cys
                 380                 385                 390

 gct gtg ttt ggt gga att tat tgt ctt cgc cat tca gta cag tgc ctt     1251
 Ala Val Phe Gly Gly Ile Tyr Cys Leu Arg His Ser Val Gln Cys Leu
             395                 400                 405

 gta gtg gac aaa gaa tcc aga aaa tgt aaa gca att ata gat cag ttt     1299
 Val Val Asp Lys Glu Ser Arg Lys Cys Lys Ala Ile Ile Asp Gln Phe
         410                 415                 420

 ggt cag aga ata atc tct gag cat ttc ctc gtg gag gac agt tac ttt     1347
 Gly Gln Arg Ile Ile Ser Glu His Phe Leu Val Glu Asp Ser Tyr Phe
     425                 430                 435

 cct gag aac atg tgc tca cgt gtg caa tac agg cag atc tcc agg gca     1395
 Pro Glu Asn Met Cys Ser Arg Val Gln Tyr Arg Gln Ile Ser Arg Ala
 440                 445                 450                 455

 gtg ctg att aca gat aga tct gtc cta aaa aca gat tca gat caa cag     1443
 Val Leu Ile Thr Asp Arg Ser Val Leu Lys Thr Asp Ser Asp Gln Gln
                 460                 465                 470

 att tcc att ttg aca gtg cca gca gag gaa cca gga act ttt gct gtt     1491
 Ile Ser Ile Leu Thr Val Pro Ala Glu Glu Pro Gly Thr Phe Ala Val
             475                 480                 485

 cgg gtc att gag tta tgt tct tca acg atg aca tgc atg aaa ggc acc     1539
 Arg Val Ile Glu Leu Cys Ser Ser Thr Met Thr Cys Met Lys Gly Thr
         490                 495                 500

 tat ttg gtt cat ttg act tgc aca tct tct aaa aca gca aga gaa gat     1587
 Tyr Leu Val His Leu Thr Cys Thr Ser Ser Lys Thr Ala Arg Glu Asp
     505                 510                 515

 tta gaa tca gtt gtg cag aaa ttg ttt gtt cca tat act gaa atg gag     1635
 Leu Glu Ser Val Val Gln Lys Leu Phe Val Pro Tyr Thr Glu Met Glu
 520                 525                 530                 535

 ata gaa aat gaa caa gta gaa aag cca aga att ctg tgg gct ctt tac     1683
 Ile Glu Asn Glu Gln Val Glu Lys Pro Arg Ile Leu Trp Ala Leu Tyr
                 540                 545                 550

 ttc aat atg aga gat tcg tca gac atc agc agg agc tgt tat aat gat     1731
 Phe Asn Met Arg Asp Ser Ser Asp Ile Ser Arg Ser Cys Tyr Asn Asp
             555                 560                 565

 tta cca tcc aac gtt tat gtc tgc tct ggc cca gat tgt ggt tta gga     1779
 Leu Pro Ser Asn Val Tyr Val Cys Ser Gly Pro Asp Cys Gly Leu Gly
         570                 575                 580

 aat gat aat gca gtc aaa cag gct gaa aca ctt ttc cag gaa atc tgc     1827
 Asn Asp Asn Ala Val Lys Gln Ala Glu Thr Leu Phe Gln Glu Ile Cys
     585                 590                 595

 ccc aat gaa gat ttc tgt ccc cct cca cca aat cct gaa gac att atc     1875
 Pro Asn Glu Asp Phe Cys Pro Pro Pro Pro Asn Pro Glu Asp Ile Ile
 600                 605                 610                 615

 ctt gat gga gac agt tta cag cca gag gct tca gaa tcc agt gcc ata     1923
 Leu Asp Gly Asp Ser Leu Gln Pro Glu Ala Ser Glu Ser Ser Ala Ile
                 620                 625                 630

 cca gag gct aac tcg gag act ttc aag gaa agc aca aac ctt gga aac     1971
 Pro Glu Ala Asn Ser Glu Thr Phe Lys Glu Ser Thr Asn Leu Gly Asn
             635                 640                 645

 cta gag gag tcc tct gaa taa tg gatatacacc aaactggata cccaactttg     2024
 Leu Glu Glu Ser Ser Glu 
         650

 gaaattctga ctggtctcag agtctacttg atagaaggac tctttgagaa atgttagaaa   2084

 gcagcagcaa ttataaggca aaataggtaa tagaaatcca aaaggggatt tt           2136




      <210> 129
      <211> 1904
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1677)

      <400> 129
  atg gag ctc ctc aac acg gtg ctt ctc tac tcc cag aac ccc cgg cgg      48
  Met Glu Leu Leu Asn Thr Val Leu Leu Tyr Ser Gln Asn Pro Arg Arg
    1               5                  10                  15

 cgc tca cgg ctc cgg aaa cgc gcc gcg ggg ctg tta gct cgg ctg ggc       96
 Arg Ser Arg Leu Arg Lys Arg Ala Ala Gly Leu Leu Ala Arg Leu Gly
              20                  25                  30

 acg ggc ggc tcc gtg gcg ctt cct gcc acg cca ggc ctg cct ggg ccg      144
 Thr Gly Gly Ser Val Ala Leu Pro Ala Thr Pro Gly Leu Pro Gly Pro
          35                  40                  45

 cgc cag cgc cgc tcc acc gag ggc cgc gcg tcg gcc gcc gcc ggg cct      192
 Arg Gln Arg Arg Ser Thr Glu Gly Arg Ala Ser Ala Ala Ala Gly Pro
      50                  55                  60

 ggc atc ttc atc cgg ttt ttt gtt gcc tct aca aag ttg gaa agg gtc      240
 Gly Ile Phe Ile Arg Phe Phe Val Ala Ser Thr Lys Leu Glu Arg Val
  65                  70                  75                  80

 tct cat ttc ctg gtt att tct tct gat gat ctt gat gga aag act gat      288
 Ser His Phe Leu Val Ile Ser Ser Asp Asp Leu Asp Gly Lys Thr Asp
                  85                  90                  95

 gag ccc tgg gaa ttc ttt cag gat ttg gtg aca ttt gat gat gtg gca      336
 Glu Pro Trp Glu Phe Phe Gln Asp Leu Val Thr Phe Asp Asp Val Ala
             100                 105                 110

 tgg tac ctc acc aca agg gag tgg ttt aag ctg gac cct gaa cag agg      384
 Trp Tyr Leu Thr Thr Arg Glu Trp Phe Lys Leu Asp Pro Glu Gln Arg
         115                 120                 125

 gca ctg gaa tat tat ggg aac gtg acc tct gtg ggc gtt cct gtt tta      432
 Ala Leu Glu Tyr Tyr Gly Asn Val Thr Ser Val Gly Val Pro Val Leu
     130                 135                 140

 aat cct gcc ttg gtc cct cac ctg gca caa gga caa gtg cta ctg gtg      480
 Asn Pro Ala Leu Val Pro His Leu Ala Gln Gly Gln Val Leu Leu Val
 145                 150                 155                 160

 tca gac cca tcg ccc aac act gat cct gct aag tac tct gaa agc acc      528
 Ser Asp Pro Ser Pro Asn Thr Asp Pro Ala Lys Tyr Ser Glu Ser Thr
                 165                 170                 175

 tcc gcg acc cga cac cag atg aag ggg gaa gat gcc cag cca cag gag      576
 Ser Ala Thr Arg His Gln Met Lys Gly Glu Asp Ala Gln Pro Gln Glu
             180                 185                 190

 atg gcg tcc aca agc ttc cca agg gcc agt ggt ccc agt cct gaa ttc      624
 Met Ala Ser Thr Ser Phe Pro Arg Ala Ser Gly Pro Ser Pro Glu Phe
         195                 200                 205

 aga cag cac ggg gac tct gac ggg aag aga ggg agc cca cag aat ctg      672
 Arg Gln His Gly Asp Ser Asp Gly Lys Arg Gly Ser Pro Gln Asn Leu
     210                 215                 220

 ccc ata gaa cat cat ttt gct tgt aaa gag tgt ggg gac acc ttt cgg      720
 Pro Ile Glu His His Phe Ala Cys Lys Glu Cys Gly Asp Thr Phe Arg
 225                 230                 235                 240

 ctt aaa gtc ctg ctt gtc cag cac cag aga gtc cac agt gag gag aag      768
 Leu Lys Val Leu Leu Val Gln His Gln Arg Val His Ser Glu Glu Lys
                 245                 250                 255

 ggc tgg gaa tgt ggc gac tgc ggg aag gtc ttt agg ggg gtg gcg gag      816
 Gly Trp Glu Cys Gly Asp Cys Gly Lys Val Phe Arg Gly Val Ala Glu
             260                 265                 270

 ttt aat gag cac agg aaa agc cac gta gct gcg gag ccc cag ccc ggc      864
 Phe Asn Glu His Arg Lys Ser His Val Ala Ala Glu Pro Gln Pro Gly
         275                 280                 285

 ccc agt agg gcc ctg gag aat gcc gcg gag aag agg gag cag atg gag      912
 Pro Ser Arg Ala Leu Glu Asn Ala Ala Glu Lys Arg Glu Gln Met Glu
     290                 295                 300

 agg gag gca aag ccc ttc gag tgc gag gag tgc gga aaa cgg ttt aag      960
 Arg Glu Ala Lys Pro Phe Glu Cys Glu Glu Cys Gly Lys Arg Phe Lys
 305                 310                 315                 320

 aag aat gca ggc ctg agt cag cat ctg agg gtc cac agc aga gag aag     1008
 Lys Asn Ala Gly Leu Ser Gln His Leu Arg Val His Ser Arg Glu Lys
                 325                 330                 335

 ccc ttt gat tgc gag gaa tgc ggg cgg tcg ttc aaa gtc aac acc cac     1056
 Pro Phe Asp Cys Glu Glu Cys Gly Arg Ser Phe Lys Val Asn Thr His
             340                 345                 350

 ctc ttc cga cat cag aaa ctt cac act tcg gaa aag cct ttc gcc tgc     1104
 Leu Phe Arg His Gln Lys Leu His Thr Ser Glu Lys Pro Phe Ala Cys
         355                 360                 365

 aag gcg tgc agc agg gat ttc ctg gat cgc cag gag ctt ctc aag cac     1152
 Lys Ala Cys Ser Arg Asp Phe Leu Asp Arg Gln Glu Leu Leu Lys His
     370                 375                 380

 cag cgc atg cac act ggc cac ctg ccc ttc gac tgc gac gac tgc ggc     1200
 Gln Arg Met His Thr Gly His Leu Pro Phe Asp Cys Asp Asp Cys Gly
 385                 390                 395                 400

 aag tcc ttc cga ggg gtc aac ggg ctg gcc gag cac cag cgc atc cac     1248
 Lys Ser Phe Arg Gly Val Asn Gly Leu Ala Glu His Gln Arg Ile His
                 405                 410                 415

 agt ggg gcc aag cca tac ggg tgt ccc cac tgc ggc aag ctc ttc cga     1296
 Ser Gly Ala Lys Pro Tyr Gly Cys Pro His Cys Gly Lys Leu Phe Arg
             420                 425                 430

 agg agc tcg gag ctc acc aag cac cgg cgg atc cac acg ggc gag aag     1344
 Arg Ser Ser Glu Leu Thr Lys His Arg Arg Ile His Thr Gly Glu Lys
         435                 440                 445

 ccc tac gcc tgc ggc cag tgc ggc aag gcc ttc cgc cag agc tcc agc     1392
 Pro Tyr Ala Cys Gly Gln Cys Gly Lys Ala Phe Arg Gln Ser Ser Ser
     450                 455                 460

 ctc ctg gag cac gca cgc atc cac agt ggc gag cgg ccc tac gca tgc     1440
 Leu Leu Glu His Ala Arg Ile His Ser Gly Glu Arg Pro Tyr Ala Cys
 465                 470                 475                 480

 ggc gag tgt ggc aag gcc ttc cgt ggg ccc tct gac ctc atc aag cac     1488
 Gly Glu Cys Gly Lys Ala Phe Arg Gly Pro Ser Asp Leu Ile Lys His
                 485                 490                 495

 cgg cgc atc cac agc gga ctg aaa ccc tat gag tgc gac aaa tgc ggc     1536
 Arg Arg Ile His Ser Gly Leu Lys Pro Tyr Glu Cys Asp Lys Cys Gly
             500                 505                 510

 aag gcc ttc cgc cgg agc tcc ggc ctc agt cgc cac cgg cgg atc cac     1584
 Lys Ala Phe Arg Arg Ser Ser Gly Leu Ser Arg His Arg Arg Ile His
         515                 520                 525

 agt ggg gcg cgg cgc tgc gaa tgc agc cag tgt ggc cgc gtg ttc aag     1632
 Ser Gly Ala Arg Arg Cys Glu Cys Ser Gln Cys Gly Arg Val Phe Lys
     530                 535                 540

 agg cgc tcg gca ctg cag aag cat cag cca acc cac cac gag tag aaa     1680
 Arg Arg Ser Ala Leu Gln Lys His Gln Pro Thr His His Glu 
 545                 550                 555

 cgccctgtgg tcccgcggga cagggacgga gtccccagag gggatggcag agtcaaagga   1740

 gatgaacagt tttgtagcgc ttatatattt tgtcttccaa aaggttgaga ccgatttata   1800

 ctgccaccag caatttataa gtgttacgtt cgcccatcaa gagtagcttg taccatttaa   1860

 cttagtttgg ctagtttaac tggtaggaag taccatcaag gtat                    1904




      <210> 130
      <211> 843
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (356)..(742)

      <400> 130
 tttttttttt gcaaagattc actttattta ttcattctcc tccaacatta gcataattaa     60

 agccaaggag gaggaggggg gtgaggtgaa agatgatctg gaggaccgca ataggggtag    120

 gtcccctgtg gaaaaagggt caaaggccaa aggatgggag ggggtcaggc tggaactgag    180

 gagcaggtgg gggcacttct ccctctaaca ctctcccctg atgaagctct ttgtgacggg    240

 cgagctcagg ccctgatggg tgacttcgca ggcgtagact ttgtgtttct cgaattctgc    300

 tttcttcagc gaggcggccg agctggttgg tggcggcggc cgagctgacg caaac atg     358
                                                              Met
                                                                1

 cag atc ttt gtg aag acc ctc act ggc aaa acc atc acc ctt gag gtc      406
 Gln Ile Phe Val Lys Thr Leu Thr Gly Lys Thr Ile Thr Leu Glu Val
               5                  10                  15

 gag ccc agt gac acc att gag aat gtc aaa gcc aaa att caa gac aag      454
 Glu Pro Ser Asp Thr Ile Glu Asn Val Lys Ala Lys Ile Gln Asp Lys
          20                  25                  30

 gag ggt atc cca cct gac cag cag cgt ctg ata ttt gcc ggc aaa cag      502
 Glu Gly Ile Pro Pro Asp Gln Gln Arg Leu Ile Phe Ala Gly Lys Gln
      35                  40                  45

 ctg gag gat ggc cgc act ctc tca gac tac aac atc cag aaa gag tcc      550
 Leu Glu Asp Gly Arg Thr Leu Ser Asp Tyr Asn Ile Gln Lys Glu Ser
  50                  55                  60                  65

 acc ctg cac ctg gtg ttg cgc ctg cga ggt ggc att att gag cct tct      598
 Thr Leu His Leu Val Leu Arg Leu Arg Gly Gly Ile Ile Glu Pro Ser
                  70                  75                  80

 ctc cgc cag ctt gcc cag aaa tac aac tgc gac aag atg atc tgc cgc      646
 Leu Arg Gln Leu Ala Gln Lys Tyr Asn Cys Asp Lys Met Ile Cys Arg
              85                  90                  95

 aag tgc tat gct cgc ctt cac cct cgt gct gtc aac tgc cgc aag aag      694
 Lys Cys Tyr Ala Arg Leu His Pro Arg Ala Val Asn Cys Arg Lys Lys
         100                 105                 110

 aag tgt ggt cac acc aac aac ctg cgt ccc aag aag aag gtc aaa taa      742
 Lys Cys Gly His Thr Asn Asn Leu Arg Pro Lys Lys Lys Val Lys 
     115                 120                 125

 ggtggttctt tccttgaagg gcagcctcct gcccaggccc cgtggccctg gagcctcaat    802

 aaagtgtccc tttcattgac tggagcagca aaaaaaaaaa a                        843




      <210> 131
      <211> 424
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (40)..(267)

      <400> 131
 gtgttgaggt tggcatacgt atcaaggaca gtaactacc   atg gct ccc gaa gtt      54
                                              Met Ala Pro Glu Val
                                                1               5

 ttg cca aaa cct cgg atg cgt ggc ctt ctg gcc agg cgt ctg cga aat      102
 Leu Pro Lys Pro Arg Met Arg Gly Leu Leu Ala Arg Arg Leu Arg Asn
                  10                  15                  20

 cat atg gct gta gca ttc gtg cta tcc ctg ggg gtt gca gct ttg tat      150
 His Met Ala Val Ala Phe Val Leu Ser Leu Gly Val Ala Ala Leu Tyr
              25                  30                  35

 aag ttt cgt gtg gct gat caa aga aag aag gca tac gca gat ttc tac      198
 Lys Phe Arg Val Ala Asp Gln Arg Lys Lys Ala Tyr Ala Asp Phe Tyr
          40                  45                  50

 aga aac tat gat gtc atg aaa gat ttt gag gag atg agg aag gct ggt      246
 Arg Asn Tyr Asp Val Met Lys Asp Phe Glu Glu Met Arg Lys Ala Gly
      55                  60                  65

 atc ttt cag agt gta aag taa tc ttggaatata aagaatttct tcaggttgaa      299
 Ile Phe Gln Ser Val Lys 
  70                  75

 ttacctagaa gtttgtcact gacttgtgtt cctgaactat gacacatgaa tatgtgggct    359

 aagaaatagt tcctcttgat aaataaacaa ttaacaaata ctttggacag taaaaaaaaa    419

 aaaaa                                                                424




      <210> 132
      <211> 913
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (162)..(602)

      <400> 132
 agaaaaggag ggggttccca tgccaaggca gaactgtctg ggacagacgc tgcccggatc     60

 cctgcggctg cctgcactct ggaccacgag ctctgagagc agcaggttga gggccggtgg    120

 gcagcagctc ggaggctccg cgaggtgcag gagacgcagg c    atg gcc ggt gag     173
                                                  Met Ala Gly Glu
                                                    1

 ctg act cct gag gag gag gcc cag tac aaa aag gct ttc tcc gcg gtt      221
 Leu Thr Pro Glu Glu Glu Ala Gln Tyr Lys Lys Ala Phe Ser Ala Val
   5                  10                  15                  20

 gac acg gat gga aac ggc acc atc aat gcc cag gag ctg ggc gcg gcg      269
 Asp Thr Asp Gly Asn Gly Thr Ile Asn Ala Gln Glu Leu Gly Ala Ala
                  25                  30                  35

 ctg aag gcc acg ggc aag aac ctc tcg gag gcc cag cta agg aaa ctc      317
 Leu Lys Ala Thr Gly Lys Asn Leu Ser Glu Ala Gln Leu Arg Lys Leu
              40                  45                  50

 atc tcc gag gtt gac agc gac ggc gac ggc gaa atc agc ttc cag gag      365
 Ile Ser Glu Val Asp Ser Asp Gly Asp Gly Glu Ile Ser Phe Gln Glu
          55                  60                  65

 ttc ctg acg gcg gcg aag aag gcc agg gcc ggc ctg gag gac ctg cag      413
 Phe Leu Thr Ala Ala Lys Lys Ala Arg Ala Gly Leu Glu Asp Leu Gln
      70                  75                  80

 gtc gcc ttc cgc gcc ttc gac cag gat ggc gac ggc cac atc acc gtg      461
 Val Ala Phe Arg Ala Phe Asp Gln Asp Gly Asp Gly His Ile Thr Val
  85                  90                  95                 100

 gac gag ctc agg cgg gcc atg gcg ggg ctg ggg cag ccg ctg ccg cag      509
 Asp Glu Leu Arg Arg Ala Met Ala Gly Leu Gly Gln Pro Leu Pro Gln
                 105                 110                 115

 gag gag ctg gac gcc atg atc cgc gag gcc gac gtg gac cag gac ggg      557
 Glu Glu Leu Asp Ala Met Ile Arg Glu Ala Asp Val Asp Gln Asp Gly
             120                 125                 130

 cgg gtg aac tac gag gag ttc gcg agg atg ctc gcc cag gag tga ggc      605
 Arg Val Asn Tyr Glu Glu Phe Ala Arg Met Leu Ala Gln Glu 
         135                 140                 145

 tccccgcctg tgtccccctg gctgcgctct gagccttcag ggccaccgcc cgctgctgct    665

 tttgtgctgg gactctccgg ggaaacctgg tcggtggatg ggaaactgcc tccccctggg    725

 aggaaggctt tgcgctccgg ggcctggatg cggcgccctc gggccgcctg cgagcccctc    785

 tctgcctcca gaccttgggc agaaggaggc ctccttgggc ctggtccccc tttgccctgc    845

 agtggaatga gggcccctca gccccgcatt gatctaaata aaggactgcc gagttcaaaa    905

 aaaaaaaa                                                             913




      <210> 133
      <211> 658
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (128)..(460)

      <400> 133
 gcaagatggc gccgcgggca tttcttccac tgcccgtctg agggaacgct aagtagtgtg     60

 tccggcgccg tgttccagct ccgcgttgtt ccgcgagaaa gcgagaggcc gagcccgggc    120

 tggtgcg  atg gcc gcg gtg gtg gcc aag cgg gaa ggg ccg ccg ttc atc     169
          Met Ala Ala Val Val Ala Lys Arg Glu Gly Pro Pro Phe Ile
            1               5                  10

 agc gag gcg gcc gtg cgg ggc aac gcc gcc gtc ctg gat tat tgc cgg      217
 Ser Glu Ala Ala Val Arg Gly Asn Ala Ala Val Leu Asp Tyr Cys Arg
  15                  20                  25                  30

 acc tcg gtg tca gcg ctg tcg ggg gcc acg gcc ggc atc ctc ggc ctc      265
 Thr Ser Val Ser Ala Leu Ser Gly Ala Thr Ala Gly Ile Leu Gly Leu
                  35                  40                  45

 acc ggc ctc tac ggc ttc atc ttc tac ctg ctc gcc tcc gtc ctg ctc      313
 Thr Gly Leu Tyr Gly Phe Ile Phe Tyr Leu Leu Ala Ser Val Leu Leu
              50                  55                  60

 tcc ctg ctc ctc att ctc aag gcg gga agg agg tgg aac aaa tat ttc      361
 Ser Leu Leu Leu Ile Leu Lys Ala Gly Arg Arg Trp Asn Lys Tyr Phe
          65                  70                  75

 aaa tca cgg aga cct ctc ttt aca gga ggc ctc atc ggg ggc ctc ttc      409
 Lys Ser Arg Arg Pro Leu Phe Thr Gly Gly Leu Ile Gly Gly Leu Phe
      80                  85                  90

 acc tac gtc ctg ttc tgg acg ttc ctc tac ggc atg gtg cac gtc tac      457
 Thr Tyr Val Leu Phe Trp Thr Phe Leu Tyr Gly Met Val His Val Tyr
  95                 100                 105                 110

 tga aatg ggggcccggg ggactttttt aaaaaaccag atcgggagga ctgtggccag      514
 


 caattaacac catgtagact tccttagttc ttaagtggtt gaattcgctg cttgttctgt    574

 aacgttataa ataatttata tctgaagacg gagagcctgt aatattcttc agattaaatg    634

 aagcgtgaga caaaaaaaaa aaaa                                           658




      <210> 134
      <211> 852
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (447)..(812)

      <400> 134
 tgaaggaccg gtccggaatt cccgggtcga cttcgctgtc gacgatttcg tgacagaagg     60

 caaaaccccc agcccttggt ctgaggtggg tgtgagggcc catctcagct cctgcacaaa    120

 ctggctgtgt gacctcaggg cactctcttg ggctctctgg actccagcct ggagactcac    180

 tcgggcctac accttcctgt ggcaaaatga cctgctgctg gcttccttgt gggcccaggg    240

 ttaaacaatg acagtaagaa tggcttttat taggcatgga gtagcaacca ccatcaccaa    300

 tctccactcc tgtatttcca tcttttaagg aaggggtccc tctaactggc acaaagggaa    360

 cagaggccct ttggtcagag atgtccctgg ggctgggcag ccttaggtgg ggctcagaac    420

 caaactgagg cgtgagcctt tgggaa atg gga aag tta ctg ctc aca gga gca     473
                              Met Gly Lys Leu Leu Leu Thr Gly Ala
                                1               5

 gtt ttt gtt ttg ttt tgt ttt ttt gag act gtc tcg ctc tgt cgt cca      521
 Val Phe Val Leu Phe Cys Phe Phe Glu Thr Val Ser Leu Cys Arg Pro
  10                  15                  20                  25

 ggc tgg att tgc aat ggt gtg atc tcg gct cac tgc aag ctc cac ctc      569
 Gly Trp Ile Cys Asn Gly Val Ile Ser Ala His Cys Lys Leu His Leu
                  30                  35                  40

 ctg ggt tca agc aat tct tgt gcc tca gcc tcc caa gta gct ggg att      617
 Leu Gly Ser Ser Asn Ser Cys Ala Ser Ala Ser Gln Val Ala Gly Ile
              45                  50                  55

 aca ggt gcc tgc cac cac gcc cgg cta att ttt gta ttt tta gta gag      665
 Thr Gly Ala Cys His His Ala Arg Leu Ile Phe Val Phe Leu Val Glu
          60                  65                  70

 acg ggg ttt cac cat gtt ggc cag gct ggt ctc aaa ctc ctg acc tca      713
 Thr Gly Phe His His Val Gly Gln Ala Gly Leu Lys Leu Leu Thr Ser
      75                  80                  85

 agt gat ctg cct gcc tca gcc tcc caa agt gct ggg att aca ggc ctg      761
 Ser Asp Leu Pro Ala Ser Ala Ser Gln Ser Ala Gly Ile Thr Gly Leu
  90                  95                 100                 105

 agc cac cgt gcc tgg cct gac agc agt ttt gag gga agc agt tcc tcg      809
 Ser His Arg Ala Trp Pro Asp Ser Ser Phe Glu Gly Ser Ser Ser Ser
                 110                 115                 120

 tga tgctggcccc tcctgcctcc cgtcgacccg ggaattccgg                      852
 






      <210> 135
      <211> 622
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (203)..(592)

      <400> 135
 atttggccct cgaggcccag aattcggcac gagcttagtc ctttggttgg attattggtt     60

 ctccaagtga cctgcacatg aacttggcac cagccaaatg ccctcaagga tacaggcaga    120

 taccacagct ccagttcctg ctttgtaaac attttacact tctattattt ctttcgtgag    180

 tgggagtctc gctctgtcac cc atg ctg gag tgc agt ggc acg atc ttg gct     232
                          Met Leu Glu Cys Ser Gly Thr Ile Leu Ala
                            1               5                  10

 cac tgc aac ctc cgc ctc ctg ggt tca agc gat tct ctt gcc tca gcc      280
 His Cys Asn Leu Arg Leu Leu Gly Ser Ser Asp Ser Leu Ala Ser Ala
                  15                  20                  25

 tct cga gta gct ggg att aca ggt atg tgc cac cac acc cag cta att      328
 Ser Arg Val Ala Gly Ile Thr Gly Met Cys His His Thr Gln Leu Ile
              30                  35                  40

 ttt ttt tta ttt ttg gta gag aca ggg ttt tgc cct gtt gac cag gct      376
 Phe Phe Leu Phe Leu Val Glu Thr Gly Phe Cys Pro Val Asp Gln Ala
          45                  50                  55

 ggt ctc aaa ctc ctg acc tca ggg gat ctg cct gcc tcg gcc tcc caa      424
 Gly Leu Lys Leu Leu Thr Ser Gly Asp Leu Pro Ala Ser Ala Ser Gln
      60                  65                  70

 agt gct agg att aca ggc atg agc cac tgc gcc cag ccc tct gtt att      472
 Ser Ala Arg Ile Thr Gly Met Ser His Cys Ala Gln Pro Ser Val Ile
  75                  80                  85                  90

 tct tta caa cac aag ttc att gtg aaa gaa ttc gaa aac gaa ccc tat      520
 Ser Leu Gln His Lys Phe Ile Val Lys Glu Phe Glu Asn Glu Pro Tyr
                  95                 100                 105

 cta gag aca tat ttc ggt gta tat cct tgg aca ttt tat atc cta gtg      568
 Leu Glu Thr Tyr Phe Gly Val Tyr Pro Trp Thr Phe Tyr Ile Leu Val
             110                 115                 120

 gct aca tgt aag tgc aca cca taa taaaactgta caaagtcaaa aaaaaaaaaa     622
 Ala Thr Cys Lys Cys Thr Pro 
         125





      <210> 136
      <211> 1170
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (165)..(950)

      <400> 136
 cacacacccc ggccacccag tcactggcca atgggctcct aggaagatca aatgtcacta     60

 taacacgagg gtgtgagccg ggcgccagtg cctgcagccg gtgctgtcca cagggagctc    120

 cagcccttct cacactcgac ccgcagaaac cacccacctt cacc atg tct gac gag     176
                                                  Met Ser Asp Glu
                                                    1

 gaa gtt gaa cag gtg gag gag cag tac gaa gaa gaa gag gaa gcc cag      224
 Glu Val Glu Gln Val Glu Glu Gln Tyr Glu Glu Glu Glu Glu Ala Gln
   5                  10                  15                  20

 gag gaa gct gca gaa gtc cat gag gaa gtt cat gaa cca gag gaa gtt      272
 Glu Glu Ala Ala Glu Val His Glu Glu Val His Glu Pro Glu Glu Val
                  25                  30                  35

 caa gaa gag gag aaa ccg aga ccc aaa ctc act gct cct aag atc cca      320
 Gln Glu Glu Glu Lys Pro Arg Pro Lys Leu Thr Ala Pro Lys Ile Pro
              40                  45                  50

 gaa ggg gag aaa gtg gac ttc gat gac atc cag aag aag cgt cag aac      368
 Glu Gly Glu Lys Val Asp Phe Asp Asp Ile Gln Lys Lys Arg Gln Asn
          55                  60                  65

 aaa gac cta atg gag ctc cag gcc ctc atc gac agc cac ttt gaa gcc      416
 Lys Asp Leu Met Glu Leu Gln Ala Leu Ile Asp Ser His Phe Glu Ala
      70                  75                  80

 cgg aag aag gag gag gag gag ctg gtc gct ctc aaa gag aga atc gag      464
 Arg Lys Lys Glu Glu Glu Glu Leu Val Ala Leu Lys Glu Arg Ile Glu
  85                  90                  95                 100

 aag cgc cgt gca gag aga gcg gag cag cag agg att cgt gca gag aag      512
 Lys Arg Arg Ala Glu Arg Ala Glu Gln Gln Arg Ile Arg Ala Glu Lys
                 105                 110                 115

 gag agg gag cgc cag aac aga ctg gcg gag gaa aag gcc aga agg gag      560
 Glu Arg Glu Arg Gln Asn Arg Leu Ala Glu Glu Lys Ala Arg Arg Glu
             120                 125                 130

 gag gag gat gcc aag agg agg gca gag gac gac ctg aag aag aag aaa      608
 Glu Glu Asp Ala Lys Arg Arg Ala Glu Asp Asp Leu Lys Lys Lys Lys
         135                 140                 145

 gct ctg tct tcc atg gga gcc aac tac agc agc tac ctg gcc aag gct      656
 Ala Leu Ser Ser Met Gly Ala Asn Tyr Ser Ser Tyr Leu Ala Lys Ala
     150                 155                 160

 gac cag aag aga ggc aag aag cag aca gcc cgg gaa atg aag aag aag      704
 Asp Gln Lys Arg Gly Lys Lys Gln Thr Ala Arg Glu Met Lys Lys Lys
 165                 170                 175                 180

 att ctg gct gag aga cgc aag ccg ctc aac atc gat cac ctt ggt gaa      752
 Ile Leu Ala Glu Arg Arg Lys Pro Leu Asn Ile Asp His Leu Gly Glu
                 185                 190                 195

 gac aaa ctg agg gac aag gcc aag gag ctc tgg gag acc ctg cac cag      800
 Asp Lys Leu Arg Asp Lys Ala Lys Glu Leu Trp Glu Thr Leu His Gln
             200                 205                 210

 ctg gag att gac aag ttc gag ttt ggg gag aag ctg aaa cgc cag aaa      848
 Leu Glu Ile Asp Lys Phe Glu Phe Gly Glu Lys Leu Lys Arg Gln Lys
         215                 220                 225

 tat gac atc acc acg ctc agg agc cgc att gac cag gcc cag aag cac      896
 Tyr Asp Ile Thr Thr Leu Arg Ser Arg Ile Asp Gln Ala Gln Lys His
     230                 235                 240

 agc aag aag gct ggg acc cca gcc aag ggc aaa gtc ggc ggg cgc tgg      944
 Ser Lys Lys Ala Gly Thr Pro Ala Lys Gly Lys Val Gly Gly Arg Trp
 245                 250                 255                 260

 aag tag agaggccaga aaggcccctc gaggcagaga ccctccgccc tcttgcacac      1000
 Lys 


 cagggccgct cgtgggactc cacatcctcc agcccccaca atcctgtcag gggctccctg   1060

 acagtcctgg gggtggagag gccatcccgg ggcgtccccc gcgtctgtgt ccttgctgcc   1120

 ttcatcccct ggggcctgtg aataaagctg cagaaccccc aaaaaaaaaa              1170




      <210> 137
      <211> 1107
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (165)..(887)

      <400> 137
 cacacacccc ggccacccag tcactggcca atgggctcct aggaagatca aatgtcacta     60

 taacacgagg gtgtgagccg ggcgccagtg cctgcagccg gtgctgtcca cagggagctc    120

 cagcccttct cacactcgac ccgcagaaac cacccacctt cacc atg tct gac gag     176
                                                  Met Ser Asp Glu
                                                    1

 gaa gtt gaa cag gtg gag gag cag tac gaa gaa gaa gag gaa gcg aaa      224
 Glu Val Glu Gln Val Glu Glu Gln Tyr Glu Glu Glu Glu Glu Ala Lys
   5                  10                  15                  20

 ccg aga ccc aaa ctc act gct cct aag atc cca gaa ggg gag aaa gtg      272
 Pro Arg Pro Lys Leu Thr Ala Pro Lys Ile Pro Glu Gly Glu Lys Val
                  25                  30                  35

 gac ttc gat gac atc cag aag aag cgt cag aac aaa gac cta atg gag      320
 Asp Phe Asp Asp Ile Gln Lys Lys Arg Gln Asn Lys Asp Leu Met Glu
              40                  45                  50

 ctc cag gcc ctc atc gac agc cac ttt gaa gcc cgg aag aag gag gag      368
 Leu Gln Ala Leu Ile Asp Ser His Phe Glu Ala Arg Lys Lys Glu Glu
          55                  60                  65

 gag gag ctg gtc gct ctc aaa gag aga atc gag aag cgc cgt gca gag      416
 Glu Glu Leu Val Ala Leu Lys Glu Arg Ile Glu Lys Arg Arg Ala Glu
      70                  75                  80

 aga gcg gag cag cag agg att cgt gca gag aag gag agg gag cgc cag      464
 Arg Ala Glu Gln Gln Arg Ile Arg Ala Glu Lys Glu Arg Glu Arg Gln
  85                  90                  95                 100

 aac aga ctg gcg gag gaa aag gcc aga agg gag gag gag gat gcc aag      512
 Asn Arg Leu Ala Glu Glu Lys Ala Arg Arg Glu Glu Glu Asp Ala Lys
                 105                 110                 115

 agg agg gca gag gac gac ctg aag aag aag aaa gct ctg tct tcc atg      560
 Arg Arg Ala Glu Asp Asp Leu Lys Lys Lys Lys Ala Leu Ser Ser Met
             120                 125                 130

 gga gcc aac tac agc agc tac ctg gcc aag gct gac cag aag aga ggc      608
 Gly Ala Asn Tyr Ser Ser Tyr Leu Ala Lys Ala Asp Gln Lys Arg Gly
         135                 140                 145

 aag aag cag aca gcc cgg gaa atg aag aag aag att ctg gct gag aga      656
 Lys Lys Gln Thr Ala Arg Glu Met Lys Lys Lys Ile Leu Ala Glu Arg
     150                 155                 160

 cgc aag ccg ctc aac atc gat cac ctt ggt gaa gac aaa ctg agg gac      704
 Arg Lys Pro Leu Asn Ile Asp His Leu Gly Glu Asp Lys Leu Arg Asp
 165                 170                 175                 180

 aag gcc aag gag ctc tgg gag acc ctg cac cag ctg gag att gac aag      752
 Lys Ala Lys Glu Leu Trp Glu Thr Leu His Gln Leu Glu Ile Asp Lys
                 185                 190                 195

 ttc gag ttt ggg gag aag ctg aaa cgc cag aaa tat gac atc acc acg      800
 Phe Glu Phe Gly Glu Lys Leu Lys Arg Gln Lys Tyr Asp Ile Thr Thr
             200                 205                 210

 ctc agg agc cgc att gac cag gcc cag aag cac agc aag aag gct ggg      848
 Leu Arg Ser Arg Ile Asp Gln Ala Gln Lys His Ser Lys Lys Ala Gly
         215                 220                 225

 acc cca gcc aag ggc aaa gtc ggc ggg cgc tgg aag tag agaggccaga       897
 Thr Pro Ala Lys Gly Lys Val Gly Gly Arg Trp Lys 
     230                 235                 240

 aaggcccctc gaggcagaga ccctccgccc tcttgcacac cagggccgct cgtgggactc    957

 cacatcctcc agcccccaca atcctgtcag gggctccctg acagtcctgg gggtggagag   1017

 gccatcccgg ggcgtccccc gcgtctgtgt ccttgctgcc ttcatcccct ggggcctgtg   1077

 aataaagctg cagaaccccc aaaaaaaaaa                                    1107




      <210> 138
      <211> 1124
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (165)..(902)

      <400> 138
 cacacacccc ggccacccag tcactggcca atgggctcct aggaagatca aatgtcacta     60

 taacacgagg gtgtgagccg ggcgccagtg cctgcagccg gtgctgtcca cagggagctc    120

 cagcccttct cacactcgac ccgcagaaac cacccacctt cacc atg tct gac gag     176
                                                  Met Ser Asp Glu
                                                    1

 gaa gtt gaa cag gtg gag gag cag tac gaa gaa gaa gag gaa gcc cag      224
 Glu Val Glu Gln Val Glu Glu Gln Tyr Glu Glu Glu Glu Glu Ala Gln
   5                  10                  15                  20

 gag gaa gag gag aaa ccg aga ccc aaa ctc act gct cct aag atc cca      272
 Glu Glu Glu Glu Lys Pro Arg Pro Lys Leu Thr Ala Pro Lys Ile Pro
                  25                  30                  35

 gaa ggg gag aaa gtg gac ttc gat gac atc cag aag aag cgt cag aac      320
 Glu Gly Glu Lys Val Asp Phe Asp Asp Ile Gln Lys Lys Arg Gln Asn
              40                  45                  50

 aaa gac cta atg gag ctc cag gcc ctc atc gac agc cac ttt gaa gcc      368
 Lys Asp Leu Met Glu Leu Gln Ala Leu Ile Asp Ser His Phe Glu Ala
          55                  60                  65

 cgg aag aag gag gag gag gag ctg gtc gct ctc aaa gag aga atc gag      416
 Arg Lys Lys Glu Glu Glu Glu Leu Val Ala Leu Lys Glu Arg Ile Glu
      70                  75                  80

 aag cgc cgt gca gag aga gcg gag cag cag agg att cgt gca gag aag      464
 Lys Arg Arg Ala Glu Arg Ala Glu Gln Gln Arg Ile Arg Ala Glu Lys
  85                  90                  95                 100

 gag agg gag cgc cag aac aga ctg gcg gag gaa aag gcc aga agg gag      512
 Glu Arg Glu Arg Gln Asn Arg Leu Ala Glu Glu Lys Ala Arg Arg Glu
                 105                 110                 115

 gag gag gat gcc aag agg agg gca gag gac gac ctg aag aag aag aaa      560
 Glu Glu Asp Ala Lys Arg Arg Ala Glu Asp Asp Leu Lys Lys Lys Lys
             120                 125                 130

 gct ctg tct tcc atg gga gcc aac tac agc agc tac ctg gcc aag gct      608
 Ala Leu Ser Ser Met Gly Ala Asn Tyr Ser Ser Tyr Leu Ala Lys Ala
         135                 140                 145

 gac cag aag aga ggc aag aag cag aca gcc cgg gaa atg aag aag aag      656
 Asp Gln Lys Arg Gly Lys Lys Gln Thr Ala Arg Glu Met Lys Lys Lys
     150                 155                 160

 att ctg gct gag aga cgc aag ccg ctc aac atc gat cac ctt ggt gaa      704
 Ile Leu Ala Glu Arg Arg Lys Pro Leu Asn Ile Asp His Leu Gly Glu
 165                 170                 175                 180

 gac aaa ctg agg gac aag gcc aag gag ctc tgg gag acc ctg cac cag      752
 Asp Lys Leu Arg Asp Lys Ala Lys Glu Leu Trp Glu Thr Leu His Gln
                 185                 190                 195

 ctg gag att gac aag ttc gag ttt ggg gag aag ctg aaa cgc cag aaa      800
 Leu Glu Ile Asp Lys Phe Glu Phe Gly Glu Lys Leu Lys Arg Gln Lys
             200                 205                 210

 tat gac atc acc acg ctc agg agc cgc att gac cag gcc cag aag cac      848
 Tyr Asp Ile Thr Thr Leu Arg Ser Arg Ile Asp Gln Ala Gln Lys His
         215                 220                 225

 agc aag aag gct ggg acc cca gcc aag ggc aaa gtc ggc ggg cgc tgg      896
 Ser Lys Lys Ala Gly Thr Pro Ala Lys Gly Lys Val Gly Gly Arg Trp
     230                 235                 240

 aag tag agaggccaga aaggcccctc gaggcagaga ccctccgccc tcttgcacac       952
 Lys 
 245

 cagggccgct cgtgggactc cacatcctcc agcccccaca atcctgtcag gggctccctg   1012

 acagtcctgg gggtggagag gccatcccgg ggcgtccccc gcgtctgtgt ccttgctgcc   1072

 ttcatcccct ggggcctgtg aataaagctg cagaaccccc aaaaaaaaaa aa           1124




      <210> 139
      <211> 1810
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (29)..(1540)

      <400> 139
 cgcttccagg ttgaatttcc tcccgacc   atg atg gtc aag ggc cgc ctg ttc      52
                                  Met Met Val Lys Gly Arg Leu Phe
                                    1               5

 gtt cct gac aga att aac ggc aca gcc aac aag atg aac gga gct ttg      100
 Val Pro Asp Arg Ile Asn Gly Thr Ala Asn Lys Met Asn Gly Ala Leu
      10                  15                  20

 gat cac tca gac caa cca gac cca gat gcc att aag atg ttt gtc gga      148
 Asp His Ser Asp Gln Pro Asp Pro Asp Ala Ile Lys Met Phe Val Gly
  25                  30                  35                  40

 cag atc ccc cgg tca tgg tcg gaa aag gag ctg aaa gaa ctt ttt gag      196
 Gln Ile Pro Arg Ser Trp Ser Glu Lys Glu Leu Lys Glu Leu Phe Glu
                  45                  50                  55

 cct tac gga gcc gtc tac cag atc aac gtc ctc cgg gac cgg agt cag      244
 Pro Tyr Gly Ala Val Tyr Gln Ile Asn Val Leu Arg Asp Arg Ser Gln
              60                  65                  70

 aac cct ccg cag agt aaa ggt tgt tgt ttc gta aca ttt tat aca aga      292
 Asn Pro Pro Gln Ser Lys Gly Cys Cys Phe Val Thr Phe Tyr Thr Arg
          75                  80                  85

 aaa gct gca ctt gag gcc cag aat gca ctg cac aat att aaa act tta      340
 Lys Ala Ala Leu Glu Ala Gln Asn Ala Leu His Asn Ile Lys Thr Leu
      90                  95                 100

 cct ggg atg cat cat ccc att cag atg aaa cct gca gat agt gaa aag      388
 Pro Gly Met His His Pro Ile Gln Met Lys Pro Ala Asp Ser Glu Lys
 105                 110                 115                 120

 tcc aac gct gtg gaa gac aga aaa ttg ttc ata gga atg gta tcg aag      436
 Ser Asn Ala Val Glu Asp Arg Lys Leu Phe Ile Gly Met Val Ser Lys
                 125                 130                 135

 aaa tgt aat gag aac gac atc agg gtg atg ttc tct cca ttt ggc cag      484
 Lys Cys Asn Glu Asn Asp Ile Arg Val Met Phe Ser Pro Phe Gly Gln
             140                 145                 150

 ata gaa gaa tgc cgg atc ctc cgg gga cct gat ggg ctg agt cga ggc      532
 Ile Glu Glu Cys Arg Ile Leu Arg Gly Pro Asp Gly Leu Ser Arg Gly
         155                 160                 165

 tgt gcg ttt gtc aca ttt tct aca agg gca atg gca cag aat gca atc      580
 Cys Ala Phe Val Thr Phe Ser Thr Arg Ala Met Ala Gln Asn Ala Ile
     170                 175                 180

 aaa gcc atg cat cag tct cag acc atg gag ggc tgc tct tca cct atc      628
 Lys Ala Met His Gln Ser Gln Thr Met Glu Gly Cys Ser Ser Pro Ile
 185                 190                 195                 200

 gtg gtg aag ttt gct gac act cag aag gac aaa gag caa agg cgc ctc      676
 Val Val Lys Phe Ala Asp Thr Gln Lys Asp Lys Glu Gln Arg Arg Leu
                 205                 210                 215

 cag cag cag ctc gct cag cag atg cag cag ctc aac act gcc acc tgg      724
 Gln Gln Gln Leu Ala Gln Gln Met Gln Gln Leu Asn Thr Ala Thr Trp
             220                 225                 230

 ggg aac ctg aca ggg ctg ggc gga ctg acc cca cag tat ctg gcg ctc      772
 Gly Asn Leu Thr Gly Leu Gly Gly Leu Thr Pro Gln Tyr Leu Ala Leu
         235                 240                 245

 ctg cag cag gcc acc tcc tcc agc aac ctg ggt gcg ttc agc ggc att      820
 Leu Gln Gln Ala Thr Ser Ser Ser Asn Leu Gly Ala Phe Ser Gly Ile
     250                 255                 260

 caa caa atg gca ggc atg aat gct tta cag ttg cag aac ctg gcg acg      868
 Gln Gln Met Ala Gly Met Asn Ala Leu Gln Leu Gln Asn Leu Ala Thr
 265                 270                 275                 280

 ctg gct gct gct gca gct gcg gcc cag acc tca gcc acc agc acc aat      916
 Leu Ala Ala Ala Ala Ala Ala Ala Gln Thr Ser Ala Thr Ser Thr Asn
                 285                 290                 295

 gca aac cct ctc tct acc acg agc agc gcc ctg gga gcc ctc acg agt      964
 Ala Asn Pro Leu Ser Thr Thr Ser Ser Ala Leu Gly Ala Leu Thr Ser
             300                 305                 310

 ccc gtg gct gct tca acc ccc aac tcc act gct ggt gca gcc atg aac     1012
 Pro Val Ala Ala Ser Thr Pro Asn Ser Thr Ala Gly Ala Ala Met Asn
         315                 320                 325

 tcc ttg acc tct ctc ggg act ctg caa gga ctg gct gga gcc act gtt     1060
 Ser Leu Thr Ser Leu Gly Thr Leu Gln Gly Leu Ala Gly Ala Thr Val
     330                 335                 340

 gga ctg aat aat att aat gca cta gca ggt atg gcg gct ctg aat gga     1108
 Gly Leu Asn Asn Ile Asn Ala Leu Ala Gly Met Ala Ala Leu Asn Gly
 345                 350                 355                 360

 gga ctt ggc gcc aca ggc ttg acg aat ggc acg gct ggc acc atg gac     1156
 Gly Leu Gly Ala Thr Gly Leu Thr Asn Gly Thr Ala Gly Thr Met Asp
                 365                 370                 375

 gcc ctc acc cag gcc tac tca gga att caa cag tac gca gcc gcc gcg     1204
 Ala Leu Thr Gln Ala Tyr Ser Gly Ile Gln Gln Tyr Ala Ala Ala Ala
             380                 385                 390

 ctg ccc act ctg tac agc cag agc ctg ctg cag cag cag agc gct gca     1252
 Leu Pro Thr Leu Tyr Ser Gln Ser Leu Leu Gln Gln Gln Ser Ala Ala
         395                 400                 405

 ggc agc cag aag gaa ggt cca gag ggg gca aac ctc ttt att tac cac     1300
 Gly Ser Gln Lys Glu Gly Pro Glu Gly Ala Asn Leu Phe Ile Tyr His
     410                 415                 420

 ctt cca cag gaa ttt gga gac cag gac att ctg cag atg ttc atg cct     1348
 Leu Pro Gln Glu Phe Gly Asp Gln Asp Ile Leu Gln Met Phe Met Pro
 425                 430                 435                 440

 ttt gga aat gtt atc tct gct aaa gtc ttc att gac aaa cag acc aat     1396
 Phe Gly Asn Val Ile Ser Ala Lys Val Phe Ile Asp Lys Gln Thr Asn
                 445                 450                 455

 ctg agc aag tgc ttt ggt ttt gtt agc tac gac aat cca gtc tct gca     1444
 Leu Ser Lys Cys Phe Gly Phe Val Ser Tyr Asp Asn Pro Val Ser Ala
             460                 465                 470

 caa gct gct atc caa gct atg aat ggc ttt cag atc ggc atg aaa cgc     1492
 Gln Ala Ala Ile Gln Ala Met Asn Gly Phe Gln Ile Gly Met Lys Arg
         475                 480                 485

 ttg aag gtg cag ctg aag cgt tcc aaa aac gac agc aaa cct tac tga     1540
 Leu Lys Val Gln Leu Lys Arg Ser Lys Asn Asp Ser Lys Pro Tyr 
     490                 495                 500

 tcctaacccc agaggctccc tgctctcatt ttagctttct tagggtaagt cccacgagcc   1600

 agcctgtctc aacagggaag gcagaggagg accacattgc caacttttac caagagagac   1660

 ggttattttt acaataaggc ctccatgtcc ccacccactt cccctaccca gtttgccata   1720

 attaaaactt gggctacttt gtttctattg agtaattcct cctccagatg tgccactgta   1780

 ttctcctttg ttttgcgatt tgaatctcct                                    1810




      <210> 140
      <211> 1059
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (288)..(905)

      <400> 140
 gtcgctcctg cgctggagct ctaggccggc gtctctccgc gagccgcggg tcaagtgcca     60

 gtggctaagg gtgcgcgagt agccgccacc cgttcggcgt tggctctggc gtcggggtcg    120

 ttgtgtcgtg acaaccgctg cggtagccgt ttccgaggca gcagttgcgg ccgctttagc    180

 cctgagcggg atctgcggct gcctgcgagt ctctgctgtg ccgacccttc tcttcgcgga    240

 ccccacgcca agcagcgacc ctgagccgac agccggagcg cccggca  atg gcg gcc     296
                                                      Met Ala Ala
                                                        1

 tcg acg gcc tcg cac cgg ccc atc aag ggg atc ttg aag aac aag acc      344
 Ser Thr Ala Ser His Arg Pro Ile Lys Gly Ile Leu Lys Asn Lys Thr
       5                  10                  15

 tct acg act tcc tct atg gtg gcg tcg gcc gaa cag ccc cgc ggg aat      392
 Ser Thr Thr Ser Ser Met Val Ala Ser Ala Glu Gln Pro Arg Gly Asn
  20                  25                  30                  35

 gtc gac gag gag ctg agc aaa aaa tcc cag aag tgg gat gaa atg aac      440
 Val Asp Glu Glu Leu Ser Lys Lys Ser Gln Lys Trp Asp Glu Met Asn
                  40                  45                  50

 atc ttg gcg acg tat cat cca gca gac aaa gac tat ggt tta atg aaa      488
 Ile Leu Ala Thr Tyr His Pro Ala Asp Lys Asp Tyr Gly Leu Met Lys
              55                  60                  65

 ata gat gaa cca agc act cct tac cat agt atg atg ggg gat gat gaa      536
 Ile Asp Glu Pro Ser Thr Pro Tyr His Ser Met Met Gly Asp Asp Glu
          70                  75                  80

 gat gcc tgt agt gac acc gag gcc act gaa gcc atg gcg cca gac atc      584
 Asp Ala Cys Ser Asp Thr Glu Ala Thr Glu Ala Met Ala Pro Asp Ile
      85                  90                  95

 tta gcc agg aaa tta gct gca gct gaa ggc ttg gag cca aag tat cgg      632
 Leu Ala Arg Lys Leu Ala Ala Ala Glu Gly Leu Glu Pro Lys Tyr Arg
 100                 105                 110                 115

 att cag gaa caa gaa agc agt gga gag gag gat agt gac ctc tca cct      680
 Ile Gln Glu Gln Glu Ser Ser Gly Glu Glu Asp Ser Asp Leu Ser Pro
                 120                 125                 130

 gaa gaa cga gaa aaa aag cga caa ttt gaa atg aaa agg aag ctt cac      728
 Glu Glu Arg Glu Lys Lys Arg Gln Phe Glu Met Lys Arg Lys Leu His
             135                 140                 145

 tac aat gaa gga ctc aat atc aaa cta gcc aga caa tta att tca aaa      776
 Tyr Asn Glu Gly Leu Asn Ile Lys Leu Ala Arg Gln Leu Ile Ser Lys
         150                 155                 160

 gac cta cat gat gat gat gaa gat gaa gaa atg tta gag act gca gat      824
 Asp Leu His Asp Asp Asp Glu Asp Glu Glu Met Leu Glu Thr Ala Asp
     165                 170                 175

 gga gaa agc atg aat acg gaa gaa tca aat caa gga tct act cca agt      872
 Gly Glu Ser Met Asn Thr Glu Glu Ser Asn Gln Gly Ser Thr Pro Ser
 180                 185                 190                 195

 gac caa cag caa aac aaa tta cga agt tca tag acgagatt tgttcaacac      923
 Asp Gln Gln Gln Asn Lys Leu Arg Ser Ser 
                 200                 205

 tgcaattgtt tgttagatgt aaaccctgtg actatagtac gttgcttctt gttcttcaca    983

 attcatgact taagtaccaa aatgcatacc agttattata tattgccaag aattaaatga   1043

 taaacttaga gactgg                                                   1059




      <210> 141
      <211> 735
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (119)..(445)

      <400> 141
 cggggccgcg atttcgtgcg gaggcagagg tggaggcgcg ttgaaaggtg agagcgcgag     60

 ggcggtgcgg ggctgtctcc cggctgggac tcgctcgcgc tcccggtgct aatggttt      118                                                                 
 atg aga ggg gcg ggg gaa gcc gtg cct cct cgc gga cta aga gaa aaa      166
 Met Arg Gly Ala Gly Glu Ala Val Pro Pro Arg Gly Leu Arg Glu Lys
   1               5                  10                  15

 ttc ccg cgg gcg ctc ttt ggg tgg gcc gga gaa cgc ccc tca gcc ctt      214
 Phe Pro Arg Ala Leu Phe Gly Trp Ala Gly Glu Arg Pro Ser Ala Leu
              20                  25                  30

 tgc gcc tct aac cct cct cag ctg agc tgc agt ggg cgc ggt gcc cgt      262
 Cys Ala Ser Asn Pro Pro Gln Leu Ser Cys Ser Gly Arg Gly Ala Arg
          35                  40                  45

 tat ttc cgc ctt ggg gag gtg ctt gga act gat gta ggg agc tcg gtt      310
 Tyr Phe Arg Leu Gly Glu Val Leu Gly Thr Asp Val Gly Ser Ser Val
      50                  55                  60

 ggt gat ttc tcg ggt ttc tgg cct ttc cag acc ctt gta att gtt ttc      358
 Gly Asp Phe Ser Gly Phe Trp Pro Phe Gln Thr Leu Val Ile Val Phe
  65                  70                  75                  80

 tcg gtg cag agc tct ttt ggg gtc tgg ggg ttt ccg tcg tcc tgc gcg      406
 Ser Val Gln Ser Ser Phe Gly Val Trp Gly Phe Pro Ser Ser Cys Ala
                  85                  90                  95

 cgt cat cgc gaa gct tgg cct gag ggt ccg gtt tcc tag ctactgtgcc       455
 Arg His Arg Glu Ala Trp Pro Glu Gly Pro Val Ser 
             100                 105

 cctccctcct ggaggcagag tgacggacta gtgggctagc gggcgctggg ttcctgcgtc    515

 ccgccaaaga ggtttgtaat catgaaagtt cacccttccg ggtgttaatt cctgagagga    575

 tctactccac tgtctaccac tcattcctgc tgcattaacc ttcattgtta acggatttta    635

 atgaataata tagttatccc ggataccatg ctggcaggat ccactttgcg aaattgtgga    695

 ctgttggact gtgattctaa gtgggggaaa taggctttag                          735




      <210> 142
      <211> 1400
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (62)..(1180)

      <400> 142
 gtcccactca aggatgcttt agaaatgata agaaagtagt ggatgtgggg aggcgcatgg     60

 g    atg aag acg gca gcg gag caa cag aag acg ctg aga gag ttc gtg     106
      Met Lys Thr Ala Ala Glu Gln Gln Lys Thr Leu Arg Glu Phe Val
        1               5                  10                  15

 gtg gtg atg ggc act gag cag gac cgg gcc tgc ttc ttc ctc gag tcg      154
 Val Val Met Gly Thr Glu Gln Asp Arg Ala Cys Phe Phe Leu Glu Ser
                  20                  25                  30

 gct acc tgg gac ttg cag att gcg cta gcg agc ttt tat gag gac aga      202
 Ala Thr Trp Asp Leu Gln Ile Ala Leu Ala Ser Phe Tyr Glu Asp Arg
              35                  40                  45

 ggg gaa gaa gac atc ata acc att tca cag gca acc ccc agt tca gtg      250
 Gly Glu Glu Asp Ile Ile Thr Ile Ser Gln Ala Thr Pro Ser Ser Val
          50                  55                  60

 tcc aga ggc aca gcc ccc agt gat aat aga gtg aca tcc ttc aga gac      298
 Ser Arg Gly Thr Ala Pro Ser Asp Asn Arg Val Thr Ser Phe Arg Asp
      65                  70                  75

 ctc att cat gac caa gat gaa gat gag gag gaa gag gaa ggc cag agg      346
 Leu Ile His Asp Gln Asp Glu Asp Glu Glu Glu Glu Glu Gly Gln Arg
  80                  85                  90                  95

 ttt tat gct ggg ggc tca gag aga agt gga cag cag att gtt ggc cct      394
 Phe Tyr Ala Gly Gly Ser Glu Arg Ser Gly Gln Gln Ile Val Gly Pro
                 100                 105                 110

 ccc agg aag aaa agt ccc aac gag ctg gtg gat gat ctc ttt aaa ggt      442
 Pro Arg Lys Lys Ser Pro Asn Glu Leu Val Asp Asp Leu Phe Lys Gly
             115                 120                 125

 gcc aaa gag cat gga gct gta gct gtg gag cga gtg acc aag agc cct      490
 Ala Lys Glu His Gly Ala Val Ala Val Glu Arg Val Thr Lys Ser Pro
         130                 135                 140

 gga gag acc agt aaa ccg aga cca ttt gca gga ggt ggc tac cgc ctt      538
 Gly Glu Thr Ser Lys Pro Arg Pro Phe Ala Gly Gly Gly Tyr Arg Leu
     145                 150                 155

 ggg gca gca cca gag gaa gag tct gcc tat gtg gca gga gaa aag agg      586
 Gly Ala Ala Pro Glu Glu Glu Ser Ala Tyr Val Ala Gly Glu Lys Arg
 160                 165                 170                 175

 cag cat tcc agc caa gat gtt cat gta gta ttg aaa ctc tgg aag agt      634
 Gln His Ser Ser Gln Asp Val His Val Val Leu Lys Leu Trp Lys Ser
                 180                 185                 190

 gga ttc agc ctg gat aat gga gaa ctc aga agc tac caa gac cca tcc      682
 Gly Phe Ser Leu Asp Asn Gly Glu Leu Arg Ser Tyr Gln Asp Pro Ser
             195                 200                 205

 aat gcc cag ttt ctg gag tct atc cgc aga ggg gag gtg cca gca gag      730
 Asn Ala Gln Phe Leu Glu Ser Ile Arg Arg Gly Glu Val Pro Ala Glu
         210                 215                 220

 ctt cgg agg cta gct cac ggt gga cag gtg aac ttg gat atg gag gac      778
 Leu Arg Arg Leu Ala His Gly Gly Gln Val Asn Leu Asp Met Glu Asp
     225                 230                 235

 cat cgg gac gag gac ttt gtg aag ccc aaa gga gcc ttc aaa gcc ttc      826
 His Arg Asp Glu Asp Phe Val Lys Pro Lys Gly Ala Phe Lys Ala Phe
 240                 245                 250                 255

 act ggc gag ggt cag aaa ctg ggc agc act gcc ccc cag gtg ttg agt      874
 Thr Gly Glu Gly Gln Lys Leu Gly Ser Thr Ala Pro Gln Val Leu Ser
                 260                 265                 270

 acc agc tct cca gcc caa cag gca gaa aat gaa gcc aaa gcc agc tct      922
 Thr Ser Ser Pro Ala Gln Gln Ala Glu Asn Glu Ala Lys Ala Ser Ser
             275                 280                 285

 tcc atc tta atc gac gaa tca gag cct acc aca aac atc caa att cgg      970
 Ser Ile Leu Ile Asp Glu Ser Glu Pro Thr Thr Asn Ile Gln Ile Arg
         290                 295                 300

 ctt gca gac ggc ggg agg ctg gtg cag aaa ttt aac cac agc cac agg     1018
 Leu Ala Asp Gly Gly Arg Leu Val Gln Lys Phe Asn His Ser His Arg
     305                 310                 315

 atc agc gac atc cga ctc ttc atc gtg gat gcc cgg cca gcc atg gct     1066
 Ile Ser Asp Ile Arg Leu Phe Ile Val Asp Ala Arg Pro Ala Met Ala
 320                 325                 330                 335

 gcc acc agc ttt atc ctc atg act act ttc ccg aac aaa gag ctg gct     1114
 Ala Thr Ser Phe Ile Leu Met Thr Thr Phe Pro Asn Lys Glu Leu Ala
                 340                 345                 350

 gat gag agc cag acc ctg aag gaa gcc aac ctg ctc aat gct gtc atc     1162
 Asp Glu Ser Gln Thr Leu Lys Glu Ala Asn Leu Leu Asn Ala Val Ile
             355                 360                 365

 gtg cag cgg tta aca taa ccgccc agccagctgc ctggcctccc tcctgtgttt     1216
 Val Gln Arg Leu Thr 
         370

 cccatggcca gtggccatgc cccatgggga tcgcccctcc tgcccccttg tgcacaccca   1276

 gcagtccagt gcaacgtctc ctccatagct ctgggttctt agatcttggt tggacgtttg   1336

 ttttctcctt agttgcattt cctgggtttt tgtgatgatc aatggacttt aatgaaaaaa   1396

 aaaa                                                                1400




      <210> 143
      <211> 2000
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (169)..(1764)

      <400> 143
 ggccccttta ggtgtcgcta aagaacacgt ttgtacaaaa aagcaggctg gtaccggtcc     60

 ggaattcccg ggaagtgcgc tcgggaggaa gtgccgatcg gctgctgggg cgaaaagggg    120

 gcgccgggcc gctctagccg ccctggtcca gcgcctccct ctctcagc atg gac gag     177
                                                      Met Asp Glu
                                                        1

 gag agc ctg gag tcg gcc ttg cag acc tac cgt gcg cag ctg cag cag      225
 Glu Ser Leu Glu Ser Ala Leu Gln Thr Tyr Arg Ala Gln Leu Gln Gln
       5                  10                  15

 gtg gag ctg gcc ttg ggc gcc ggc ctg gat tcg tct gag cag gct gac      273
 Val Glu Leu Ala Leu Gly Ala Gly Leu Asp Ser Ser Glu Gln Ala Asp
  20                  25                  30                  35

 ctg cgc cag ctg cag ggg gac ctg aag gag ctc atc gag ctc acc gag      321
 Leu Arg Gln Leu Gln Gly Asp Leu Lys Glu Leu Ile Glu Leu Thr Glu
                  40                  45                  50

 gcc agc ctg gtg tct gtc agg aag agc agg ttg ttg gcc gcg ctg gac      369
 Ala Ser Leu Val Ser Val Arg Lys Ser Arg Leu Leu Ala Ala Leu Asp
              55                  60                  65

 gaa gag cgc ccg ggc cgc cag gaa gat gct gag tac cag gct ttc cgg      417
 Glu Glu Arg Pro Gly Arg Gln Glu Asp Ala Glu Tyr Gln Ala Phe Arg
          70                  75                  80

 gag gcc atc act gag gcg gtg gag gca cca gca gcg gcc cgt ggg tcc      465
 Glu Ala Ile Thr Glu Ala Val Glu Ala Pro Ala Ala Ala Arg Gly Ser
      85                  90                  95

 gga tca gag acc gtt cct aaa gca gag gcg ggg cca gaa tct gcg gca      513
 Gly Ser Glu Thr Val Pro Lys Ala Glu Ala Gly Pro Glu Ser Ala Ala
 100                 105                 110                 115

 ggt ggg cag gag gag gaa gag gga gag gac gag gaa gag ctg agt ggg      561
 Gly Gly Gln Glu Glu Glu Glu Gly Glu Asp Glu Glu Glu Leu Ser Gly
                 120                 125                 130

 aca aag gtg agc gcg ccc tac tac agc tcc tgg ggc act ctg gag tat      609
 Thr Lys Val Ser Ala Pro Tyr Tyr Ser Ser Trp Gly Thr Leu Glu Tyr
             135                 140                 145

 cac aac gcc atg gtg gcg gga acg gaa gag gcg gag gat ggc tcg gcg      657
 His Asn Ala Met Val Ala Gly Thr Glu Glu Ala Glu Asp Gly Ser Ala
         150                 155                 160

 ggt gtc cgt gtg ctt tac ctg tac ccc act cac aag tct ctg aag ccg      705
 Gly Val Arg Val Leu Tyr Leu Tyr Pro Thr His Lys Ser Leu Lys Pro
     165                 170                 175

 cgc ccg ttc ttc ctg gag gga aag tgc cgc ttt aag gag aac tgc agg      753
 Arg Pro Phe Phe Leu Glu Gly Lys Cys Arg Phe Lys Glu Asn Cys Arg
 180                 185                 190                 195

 ttc tcc cat ggg cag gtg ggc tct ctg gat gag ctg cgc ccc ttc cag      801
 Phe Ser His Gly Gln Val Gly Ser Leu Asp Glu Leu Arg Pro Phe Gln
                 200                 205                 210

 gac cca gac ctg agc tcc ctg cag gcc ggc tct gcg tgt ctg gcc aag      849
 Asp Pro Asp Leu Ser Ser Leu Gln Ala Gly Ser Ala Cys Leu Ala Lys
             215                 220                 225

 cac cag gat ggc ctc tgg cac gca gca cgc atc acc gat gtg gac aac      897
 His Gln Asp Gly Leu Trp His Ala Ala Arg Ile Thr Asp Val Asp Asn
         230                 235                 240

 ggc tac tac aca gtc aag ttt gac tcg ctg ctg ctg agg gag gcc gtg      945
 Gly Tyr Tyr Thr Val Lys Phe Asp Ser Leu Leu Leu Arg Glu Ala Val
     245                 250                 255

 gtg gag ggg gac ggc atc ctg ccc cca ctg cgc aca gag gcc aca gag      993
 Val Glu Gly Asp Gly Ile Leu Pro Pro Leu Arg Thr Glu Ala Thr Glu
 260                 265                 270                 275

 tcc gac tca gac agc gac ggt acg ggt gac tcc agc tat gcc aga gtg     1041
 Ser Asp Ser Asp Ser Asp Gly Thr Gly Asp Ser Ser Tyr Ala Arg Val
                 280                 285                 290

 gtg ggg tcg gac gcc gtg gac tct gca cag tcc tct gcc ctc tgt ccg     1089
 Val Gly Ser Asp Ala Val Asp Ser Ala Gln Ser Ser Ala Leu Cys Pro
             295                 300                 305

 tct ctt gca gtg gtg ggg tca gat gct gtg gac tct ggg acc tgc agc     1137
 Ser Leu Ala Val Val Gly Ser Asp Ala Val Asp Ser Gly Thr Cys Ser
         310                 315                 320

 tct gcc ttt gct ggc tgg gag gtg cac acg cga ggt ata ggc tcc aga     1185
 Ser Ala Phe Ala Gly Trp Glu Val His Thr Arg Gly Ile Gly Ser Arg
     325                 330                 335

 ctc ctc acc aag atg ggc tat gag ttt ggc aag ggt ttg ggc cga cac     1233
 Leu Leu Thr Lys Met Gly Tyr Glu Phe Gly Lys Gly Leu Gly Arg His
 340                 345                 350                 355

 gcg gaa ggc cgg gtg gag ccc atc cat gct gtg gtg ttg cct cga ggg     1281
 Ala Glu Gly Arg Val Glu Pro Ile His Ala Val Val Leu Pro Arg Gly
                 360                 365                 370

 aag tcg ctg gac cag tgt gtg gag acc ctg cag aag cag acc agg gtt     1329
 Lys Ser Leu Asp Gln Cys Val Glu Thr Leu Gln Lys Gln Thr Arg Val
             375                 380                 385

 ggc aag gct ggc acc aac aag ccc ccc agg tgc cgg gga aga ggg gcc     1377
 Gly Lys Ala Gly Thr Asn Lys Pro Pro Arg Cys Arg Gly Arg Gly Ala
         390                 395                 400

 agg cct ggg ggc cgc cca gct cct cgg aat gtg ttt gac ttc ctc aat     1425
 Arg Pro Gly Gly Arg Pro Ala Pro Arg Asn Val Phe Asp Phe Leu Asn
     405                 410                 415

 gaa aag ctg caa ggt cag gct cct ggg gcc ctc gag gcc ggg gcg gcc     1473
 Glu Lys Leu Gln Gly Gln Ala Pro Gly Ala Leu Glu Ala Gly Ala Ala
 420                 425                 430                 435

 cca gcg ggg agg agg agc aag gac atg tac cat gcc agc aag agt gcc     1521
 Pro Ala Gly Arg Arg Ser Lys Asp Met Tyr His Ala Ser Lys Ser Ala
                 440                 445                 450

 aag cgg gcc ctg agc ctg cgg ctc ttc cag act gag gag aag atc gag     1569
 Lys Arg Ala Leu Ser Leu Arg Leu Phe Gln Thr Glu Glu Lys Ile Glu
             455                 460                 465

 cga acc cag cgg gac atc agg agc atc cag gag gct ctc gcc cgc aac     1617
 Arg Thr Gln Arg Asp Ile Arg Ser Ile Gln Glu Ala Leu Ala Arg Asn
         470                 475                 480

 gct ggc cgg cat agc gtg gcg tca gcc cag ctg cag gag aag ctg gca     1665
 Ala Gly Arg His Ser Val Ala Ser Ala Gln Leu Gln Glu Lys Leu Ala
     485                 490                 495

 gga gcc cag cgc cag ctg ggg cag ctc cgg gct cag gaa gcc ggc ctg     1713
 Gly Ala Gln Arg Gln Leu Gly Gln Leu Arg Ala Gln Glu Ala Gly Leu
 500                 505                 510                 515

 cag cag gag cag agg aag gca gac acc cac aag aag atg act gag ttc     1761
 Gln Gln Glu Gln Arg Lys Ala Asp Thr His Lys Lys Met Thr Glu Phe
                 520                 525                 530

 tag agac cccacaagca ctatggacga agcgtgggac cccagcacgg gctgccctca     1818
 


 ggaagaccag tgttgcccga ggaggggccg gcctgctggc ctggggcgtg cggacactgc   1878

 tgagtggaga cagagctgcg gggtcccatc tggacactta cttgcccacc tgccagtgtc   1938

 ttgggcattt ccttggcaag gacattaaag tgatttcatc acagtgtcaa aaaaaaaaaa   1998

 aa                                                                  2000




      <210> 144
      <211> 1152
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (19)..(246)

      <400> 144
 cttcctcagg cggcggcc  atg gcg gga cag gag gat ccg gtg cag cgg gag      51
                      Met Ala Gly Gln Glu Asp Pro Val Gln Arg Glu
                        1               5                  10

 att cac cag gac tgg gct aac cgg gag tac att gag ata atc acc agc       99
 Ile His Gln Asp Trp Ala Asn Arg Glu Tyr Ile Glu Ile Ile Thr Ser
              15                  20                  25

 agc atc aag aaa atc gca gac ttt ctc aac tcg ttc gat atg tct tgt      147
 Ser Ile Lys Lys Ile Ala Asp Phe Leu Asn Ser Phe Asp Met Ser Cys
          30                  35                  40

 cgt tca aga ctt gca aca cta aac gag aaa ttg aca gcc ctt gaa cgg      195
 Arg Ser Arg Leu Ala Thr Leu Asn Glu Lys Leu Thr Ala Leu Glu Arg
      45                  50                  55

 aga ata gag tac att gaa gct cgg gtg aca aaa ggt gag aca ctc acc      243
 Arg Ile Glu Tyr Ile Glu Ala Arg Val Thr Lys Gly Glu Thr Leu Thr
  60                  65                  70                  75

 tag aaca gtgccgtgct gctgctggga agttgcttta cacaacacag gccacatggg      300
 


 aaaggcccca gcagccttca gctccttcct ttctccttaa agagcaacag ggcttattct    360

 tgtttttctt ttttcaaaag tgtggccttt gggctctgcc atctggggtg tggtgtggta    420

 tgtgggaaga agttcagagg aaccgttgga aacgacgtta ggcattttac cttttcagta    480

 acattttata catctacttg tcaatgtatt tgagacattc acagccaaaa gcctgggact    540

 ctttgtgaag gtcctcctca cctctatctt tctttctctc tctctcaaac tttccttaaa    600

 gttctcattg cctttgcact gcttctgtga acagtctttg tctcctcccc acctttggtg    660

 ggaagtgcgg ggcagtcctg gtcaagacac tcatgccctg gcaatgtggc tgccagagaa    720

 tgttgttgct aacccaccag tttcttgttg atttggagag gtcaaggcca ggcccccact    780

 tggcttgaag ggacattttc agacttttct ttctgtcact tggagtgtct atgcctctca    840

 tatttcccta ataaactcct caacttttta tctgactgct gtgattatgg tggggagagg    900

 agctagagat gggttcactt attgcacaga aatgtaatac atggcgttat tattctaaca    960

 taaaactttc agatgtagct gtttgattca aagcctaggt ggcttaccag cccaagtccc   1020

 catgtttgga ctttcagctg actagctcat cttgggaatc atttggtcat tcagcacatt   1080

 taccaagtat ttactatgta ggcatgttaa actccaataa aacatacagc attgaatcag   1140

 aaaaaaaaaa aa                                                       1152




      <210> 145
      <211> 2133
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (599)..(1165)

      <220>
      <221> misc_feature
      <222> (1)...(2133)
      <223> n = a,t,c or g

      <400> 145
 taagcttggg ccgagctgtc cgacgtgtca ctgcagggac ccgcccgggg tgggtctcgg     60

 gctctcgcta ccggagaggg aggagaaggg ggaggttaaa ggggaaggac cccggaagtg    120

 ccccctcctc agtgcgggag agggagacgc cgggggcang tccatgcctc ccgcggcgtg    180

 gttggtgcgt cccaggtgac gtcagaagca gcccgcccct gcctggatgg tgcgccctga    240

 gtgacgtcag gagcagaggc cggagctgtc catcagcacc aaaggccgcg ggcgggctca    300

 gggcatgggg ccgcggttct ggggcggccg agcccgngct cctgcgcctt ccccttcctc    360

 aggcccagcc cgagttcccg gacgccgcgg gactggagtg ccagccggtg ttggacgtgg    420

 agcggcgccg ccaccgcgcc gacaccattc tctccggccc agcagccccc ttcctcgcac    480

 gacggacttt ccctggaccc cagtcagttg gagcctctgg cgccccgcaa ccccggcccc    540

 tcgggcctct gcacagcctc tttcactcag aagctcaggt cgcctccagc ccagcact      598                                                                 
 atg ccg ggg act gtg gca aca ctg cgg ttc cag ctg ctg ccc cct gag      646
 Met Pro Gly Thr Val Ala Thr Leu Arg Phe Gln Leu Leu Pro Pro Glu
   1               5                  10                  15

 cca gat gat gcc ttc tgg ggt gca cct tgt gaa cag ccc ctg gag cgc      694
 Pro Asp Asp Ala Phe Trp Gly Ala Pro Cys Glu Gln Pro Leu Glu Arg
              20                  25                  30

 agg tac cag gca ctg ccg gcc ctc gtc tgc atc atg tgc tgt ttg ttt      742
 Arg Tyr Gln Ala Leu Pro Ala Leu Val Cys Ile Met Cys Cys Leu Phe
          35                  40                  45

 gga gtc gtc tac tgc ttc ttc ggt tac cgc tgc ttc aag gca gtg ctc      790
 Gly Val Val Tyr Cys Phe Phe Gly Tyr Arg Cys Phe Lys Ala Val Leu
      50                  55                  60

 ttc ctc act ggg ttg ctg ttt ggc tcg gtg gtc atc ttc ctc ctc tgc      838
 Phe Leu Thr Gly Leu Leu Phe Gly Ser Val Val Ile Phe Leu Leu Cys
  65                  70                  75                  80

 tac cga gag cgg gtg cta gag aca cag ctg agt gct ggg gcg agc gcg      886
 Tyr Arg Glu Arg Val Leu Glu Thr Gln Leu Ser Ala Gly Ala Ser Ala
                  85                  90                  95

 ggc atc gct ctg ggc atc ggg ctg ctc tgc ggg ctg gtg gcc atg cta      934
 Gly Ile Ala Leu Gly Ile Gly Leu Leu Cys Gly Leu Val Ala Met Leu
             100                 105                 110

 gtg cgc agc gtg ggc ctc ttc ctg gtg ggg ctg ctg ctc ggc ctg ctg      982
 Val Arg Ser Val Gly Leu Phe Leu Val Gly Leu Leu Leu Gly Leu Leu
         115                 120                 125

 ctc gca gct gct gcc ctg ctg ggc tcc gca ccc tac tac cag cca ggc     1030
 Leu Ala Ala Ala Ala Leu Leu Gly Ser Ala Pro Tyr Tyr Gln Pro Gly
     130                 135                 140

 tcc gtg tgg ggt cca ctg ggg ctg ttg cct ggg ggg cgg cct gct ctg     1078
 Ser Val Trp Gly Pro Leu Gly Leu Leu Pro Gly Gly Arg Pro Ala Leu
 145                 150                 155                 160

 tgc cct gct cac tct gcg ctg gcc ccg ccc act cac cac cct ggc cac     1126
 Cys Pro Ala His Ser Ala Leu Ala Pro Pro Thr His His Pro Gly His
                 165                 170                 175

 cgc cgt gac tgg tgc tgc gct gat cgc cac tgc cgc tga ctacttcgcc      1175
 Arg Arg Asp Trp Cys Cys Ala Asp Arg His Cys Arg 
             180                 185

 gagctgctac tgctggggcg ctacgtggtg gagcgactcc gggctgctcc tgtgccccca   1235

 ctctgctggc gaagctgggc cctgctggca ctctggcccc tgctcagcct gatgggcgtt   1295

 ctggtgcagt ggagggtgac agctgagggg gactcccaca cggaagtggt catcagccgg   1355

 cagcgccgac gcgtgcaact gatgcggatt cggcagcagg aagatcgcaa gggagaaaag   1415

 gcgggaaaaa gagacctcct cgggctcccc tcagaggtcc ccgggctcct cccaggcctg   1475

 ggccaccaga tcccgcttat cggcgcaggc cagtgcccat caaacgcttc aatggagacg   1535

 tcctctcccc gagctatatc cagagcttcc gagaccggca gaccgggagc tccctgagct   1595

 ccttcatggc ctcacccaca gatgcggact atgagtatgg gtcccgggga cctctgacag   1655

 cctgctcagg ccccccagtg cgggtatagc catatctgtc tgtctagact ctgcagtcac   1715

 cagctctgcc agctcgagga ggcctgctag gctgccactc agcctcctgg ctttggctgt   1775

 ccctctcccc agcctggaga gggctggcct ggtcactaga agggaggatt gtctcaggcg   1835

 agtcttggcc tgagaggaaa gccccctccc aagctcccaa gaggctcctg aggaactcgg   1895

 ggtgtgaacc ccattggggt gtgctcaggg ttgtgagtgt gttgcccgtg tgtctgtgtg   1955

 tatgtgtgtg ggggtgggca ggcttggagg ggacgctggg acccttgcct tagatttctg   2015

 actggtaggg tttctccagg ctcagcccca cctcttcact ccctgccaag gtcccatggg   2075

 ccacctcctg catgtctccg cggaggggct accttccttc ccatcgccct gcctcgcg     2133




      <210> 146
      <211> 1612
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (463)..(1539)

      <400> 146
 taatccagga tctgactgag gcagactgcg attcggcata tagaacttat atcctgccag     60

 ggcctcggtt tcaaaaacac cttctgcaac ttccgtcagt ggccactcca gcttcctggc    120

 gttgctgaca gcctggctag aagcgagcgt gattcccata aagtcattgc caagcttgta    180

 gtctccgacg ccataattgt aagtcagttc tgcgacaaaa tgatcatcct caggcccaaa    240

 tcccaccatt gttttactcc atttcccatc ataaggccca ttacaggcag ctttgcagcc    300

 ttcttcaaat tcctcatgcc gcagaacctt catccccagg acgtcccgat agaaacgcgc    360

 cgtctggaag cggtttccca ctttgaatac gaagtgcaga gctctgcgag cagccatgat    420

 tcccaggctt aagtgatcct ttttaagaag atttattcct ct   atg atg gag aag     474
                                                  Met Met Glu Lys
                                                    1

 tat gaa aaa att ggg aaa att gga gaa gga tcc tat gga gtt gtt ttc      522
 Tyr Glu Lys Ile Gly Lys Ile Gly Glu Gly Ser Tyr Gly Val Val Phe
   5                  10                  15                  20

 aaa tgt aga aac agg gac acg ggt cag att gtg gcc atc aag aag ttt      570
 Lys Cys Arg Asn Arg Asp Thr Gly Gln Ile Val Ala Ile Lys Lys Phe
                  25                  30                  35

 ctg gaa tca gaa gat gac cct gtc ata aag aaa att gcc ctt cgg gaa      618
 Leu Glu Ser Glu Asp Asp Pro Val Ile Lys Lys Ile Ala Leu Arg Glu
              40                  45                  50

 atc cga atg ctc aag caa ctc aag cat ccc aac ctt gtt aac ctc ctg      666
 Ile Arg Met Leu Lys Gln Leu Lys His Pro Asn Leu Val Asn Leu Leu
          55                  60                  65

 gaa gtc ttc agg agg aaa cgg agg ctt cac ctg gtg ttt gaa tat tgt      714
 Glu Val Phe Arg Arg Lys Arg Arg Leu His Leu Val Phe Glu Tyr Cys
      70                  75                  80

 gac cac aca gtt ctc cat gag ttg gac aga tac caa aga ggg gta cca      762
 Asp His Thr Val Leu His Glu Leu Asp Arg Tyr Gln Arg Gly Val Pro
  85                  90                  95                 100

 gaa cat ctc gtg aag agc ata act tgg cag aca ctg caa gct gta aat      810
 Glu His Leu Val Lys Ser Ile Thr Trp Gln Thr Leu Gln Ala Val Asn
                 105                 110                 115

 ttt tgc cat aaa cac aat tgc ata cat aga gac gtg aag cca gaa aat      858
 Phe Cys His Lys His Asn Cys Ile His Arg Asp Val Lys Pro Glu Asn
             120                 125                 130

 atc ctc atc acg aaa cat tcc gtg att aag ctt tgt gac ttt gga ttt      906
 Ile Leu Ile Thr Lys His Ser Val Ile Lys Leu Cys Asp Phe Gly Phe
         135                 140                 145

 gct cgg ctt ttg act gga ccg agt gac tac tat aca gac tac gtg gct      954
 Ala Arg Leu Leu Thr Gly Pro Ser Asp Tyr Tyr Thr Asp Tyr Val Ala
     150                 155                 160

 acc agg tgg tac cgc tcc cct gag ctg ctg gtg ggg gac acg cag tac     1002
 Thr Arg Trp Tyr Arg Ser Pro Glu Leu Leu Val Gly Asp Thr Gln Tyr
 165                 170                 175                 180

 ggc ccc ccg gtg gat gtt tgg gca att ggc tgt gtc ttt gct gag ctg     1050
 Gly Pro Pro Val Asp Val Trp Ala Ile Gly Cys Val Phe Ala Glu Leu
                 185                 190                 195

 ctg tca gga gtg cct ctg tgg cca gga aaa tcg gat gtg gat cag ctg     1098
 Leu Ser Gly Val Pro Leu Trp Pro Gly Lys Ser Asp Val Asp Gln Leu
             200                 205                 210

 tat ctg att agg aag acc ttg ggg gat ctc att cct agg cac cag caa     1146
 Tyr Leu Ile Arg Lys Thr Leu Gly Asp Leu Ile Pro Arg His Gln Gln
         215                 220                 225

 gtg ttt agc acg aat cag tac ttc agt gga gtg aaa att cca gac cct     1194
 Val Phe Ser Thr Asn Gln Tyr Phe Ser Gly Val Lys Ile Pro Asp Pro
     230                 235                 240

 gaa gat atg gaa cca ctt gaa tta aaa ttc cca aac atc tct tat cct     1242
 Glu Asp Met Glu Pro Leu Glu Leu Lys Phe Pro Asn Ile Ser Tyr Pro
 245                 250                 255                 260

 gcc ctg ggg ctc cta aag ggc tgt ctc cac atg gac cct act gaa agg     1290
 Ala Leu Gly Leu Leu Lys Gly Cys Leu His Met Asp Pro Thr Glu Arg
                 265                 270                 275

 ctg aca tgt gaa cag ctg ttg cat cac cca tat ttt gaa aac atc aga     1338
 Leu Thr Cys Glu Gln Leu Leu His His Pro Tyr Phe Glu Asn Ile Arg
             280                 285                 290

 gaa ata gag gat ttg gca aaa gaa cac aac aaa cca aca agg aag acc     1386
 Glu Ile Glu Asp Leu Ala Lys Glu His Asn Lys Pro Thr Arg Lys Thr
         295                 300                 305

 cta aga aag agc cga aag cac cac tgc ttt aca gaa aca tcc aag ttg     1434
 Leu Arg Lys Ser Arg Lys His His Cys Phe Thr Glu Thr Ser Lys Leu
     310                 315                 320

 cag tac cta ccc cag cta act ggc agc agc atc ctt cca gct ttg gat     1482
 Gln Tyr Leu Pro Gln Leu Thr Gly Ser Ser Ile Leu Pro Ala Leu Asp
 325                 330                 335                 340

 aat aag aag tac tac tgt gat acc aag aaa ctt aac tac cgt ttt cca     1530
 Asn Lys Lys Tyr Tyr Cys Asp Thr Lys Lys Leu Asn Tyr Arg Phe Pro
                 345                 350                 355

 aac att taa aggagct aaggagagat gattttaaaa aaggaatcaa tagatgcttt     1586
 Asn Ile 


 gaagaaaata aaacttatac agttca                                        1612




      <210> 147
      <211> 2283
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (71)..(1414)

      <400> 147
 cagggatttg aaccgcgctg acgaagtttg gtgatccatc ttccgagtat cgccgggatt     60

 tcgaatcgcg   atg atc atc ccc tct cta gag gag ctg gac tcc ctc aag     109
              Met Ile Ile Pro Ser Leu Glu Glu Leu Asp Ser Leu Lys
                1               5                  10

 tac agt gac ctg cag aac tta gcc aag agt ctg ggt ctc cgg gcc aac      157
 Tyr Ser Asp Leu Gln Asn Leu Ala Lys Ser Leu Gly Leu Arg Ala Asn
      15                  20                  25

 ctg agg gca acc aag ttg tta aaa gcc ttg aaa ggc tac att aaa cat      205
 Leu Arg Ala Thr Lys Leu Leu Lys Ala Leu Lys Gly Tyr Ile Lys His
  30                  35                  40                  45

 gag gca aga aaa gga aat gag aat cag gat gaa agt caa act tct gca      253
 Glu Ala Arg Lys Gly Asn Glu Asn Gln Asp Glu Ser Gln Thr Ser Ala
                  50                  55                  60

 tcc tct tgt gat gag act gag ata cag atc agc aac cag gaa gaa gct      301
 Ser Ser Cys Asp Glu Thr Glu Ile Gln Ile Ser Asn Gln Glu Glu Ala
              65                  70                  75

 gag aga cag cca ctt ggc cat gtc acc aaa aca agg aga agg tgc aag      349
 Glu Arg Gln Pro Leu Gly His Val Thr Lys Thr Arg Arg Arg Cys Lys
          80                  85                  90

 act gtc cgt gtg gac cct gac tca cag cag aat cat tca gag ata aaa      397
 Thr Val Arg Val Asp Pro Asp Ser Gln Gln Asn His Ser Glu Ile Lys
      95                 100                 105

 ata agt aat ccc act gaa ttc cag aat cat gaa aag cag gaa agc cag      445
 Ile Ser Asn Pro Thr Glu Phe Gln Asn His Glu Lys Gln Glu Ser Gln
 110                 115                 120                 125

 gat ctc aga gct act gca aaa gtt cct tct cca cca gac gag cac caa      493
 Asp Leu Arg Ala Thr Ala Lys Val Pro Ser Pro Pro Asp Glu His Gln
                 130                 135                 140

 gaa gct gag aat gct gtt tcc tca ggt aaa cgt gga ata aat ggt aac      541
 Glu Ala Glu Asn Ala Val Ser Ser Gly Lys Arg Gly Ile Asn Gly Asn
             145                 150                 155

 aga gat tca aag gta cct tca gaa gga aag aaa tct ctc tac aca gat      589
 Arg Asp Ser Lys Val Pro Ser Glu Gly Lys Lys Ser Leu Tyr Thr Asp
         160                 165                 170

 gag tca tcc aaa cct gga aaa aat aaa aga act gca atc act act cca      637
 Glu Ser Ser Lys Pro Gly Lys Asn Lys Arg Thr Ala Ile Thr Thr Pro
     175                 180                 185

 aac ttt aag aag ctt cat gaa gct cat ttt aag gaa atg gag tcc att      685
 Asn Phe Lys Lys Leu His Glu Ala His Phe Lys Glu Met Glu Ser Ile
 190                 195                 200                 205

 gat caa tat att gag aga aaa aaa aaa cat ttt gaa gaa cac aat tcc      733
 Asp Gln Tyr Ile Glu Arg Lys Lys Lys His Phe Glu Glu His Asn Ser
                 210                 215                 220

 atg aat gaa ctg aag cag cag ccc atc aat aag gga ggg gtc agg act      781
 Met Asn Glu Leu Lys Gln Gln Pro Ile Asn Lys Gly Gly Val Arg Thr
             225                 230                 235

 cca gta cct cca aga gga aga ctc tct gtg gct tct act ccc atc agc      829
 Pro Val Pro Pro Arg Gly Arg Leu Ser Val Ala Ser Thr Pro Ile Ser
         240                 245                 250

 caa cga cgc tcg caa ggc cgg tct tgt ggc cct gca agt cag agt acc      877
 Gln Arg Arg Ser Gln Gly Arg Ser Cys Gly Pro Ala Ser Gln Ser Thr
     255                 260                 265

 ttg ggt ctg aag ggg tca ctc aag cgc tct gct atc tct gca gct aaa      925
 Leu Gly Leu Lys Gly Ser Leu Lys Arg Ser Ala Ile Ser Ala Ala Lys
 270                 275                 280                 285

 acg ggt gtc agg ttt tca gct gct act aaa gat aat gag cat aag cgt      973
 Thr Gly Val Arg Phe Ser Ala Ala Thr Lys Asp Asn Glu His Lys Arg
                 290                 295                 300

 tca ctg acc aag act cca gcc aga aag tct gca cat gtg acc gtg tct     1021
 Ser Leu Thr Lys Thr Pro Ala Arg Lys Ser Ala His Val Thr Val Ser
             305                 310                 315

 ggg ggc acc cca aaa ggc gag gct gtg ctt ggg aca cac aaa tta aag     1069
 Gly Gly Thr Pro Lys Gly Glu Ala Val Leu Gly Thr His Lys Leu Lys
         320                 325                 330

 acc atc acg ggg aat tct gct gct gtt att acc cca ttc aag ttg aca     1117
 Thr Ile Thr Gly Asn Ser Ala Ala Val Ile Thr Pro Phe Lys Leu Thr
     335                 340                 345

 act gag gca acg cag act cca gtc tcc aat aag aaa cca gtg ttt gat     1165
 Thr Glu Ala Thr Gln Thr Pro Val Ser Asn Lys Lys Pro Val Phe Asp
 350                 355                 360                 365

 ctt aaa gca agt ttg tct cgt ccc ctc aac tat gaa cca cac aaa gga     1213
 Leu Lys Ala Ser Leu Ser Arg Pro Leu Asn Tyr Glu Pro His Lys Gly
                 370                 375                 380

 aag cta aaa cca tgg ggg caa tct aaa gaa aat aat tat cta aat caa     1261
 Lys Leu Lys Pro Trp Gly Gln Ser Lys Glu Asn Asn Tyr Leu Asn Gln
             385                 390                 395

 cat gtc aac aga att aac ttc tac aag aaa act tac aaa caa ccc cat     1309
 His Val Asn Arg Ile Asn Phe Tyr Lys Lys Thr Tyr Lys Gln Pro His
         400                 405                 410

 ctc cag aca aag gaa gag caa cgg aag aaa cgc gag caa gaa cga aag     1357
 Leu Gln Thr Lys Glu Glu Gln Arg Lys Lys Arg Glu Gln Glu Arg Lys
     415                 420                 425

 gag aag aaa gca aag gtt ttg gga atg cga agg ggc ctc att ttg gct     1405
 Glu Lys Lys Ala Lys Val Leu Gly Met Arg Arg Gly Leu Ile Leu Ala
 430                 435                 440                 445

 gaa gat taa taatttt ttaacatctt gtaaatattc ctgtattctc aacttttttc     1461
 Glu Asp 


 cttttgtaaa tttttttttt tttgctgtca tccccacttt agtcacgaga tctttttctg   1521

 ctaactgttc atagtctgtg tagtgtccat gggttcttca tgtgctatga tctctgaaaa   1581

 gacgttatca ccttaaagct caaattcttt gggatggttt ttacttaagt ccattaacaa   1641

 ttcaggtttc taacgagacc catcctaaaa ttctgtttct agatttttaa tgtcaagttc   1701

 ccaagttccc cctgctggtt ctaatattaa cagaactgca gtcttctgct agccaatagc   1761

 atttacctga tggcagctag ttatgcaagc ttcaggagaa tttgaacaat aacaagaata   1821

 gggtaagctg ggatagaaag gccacctctt cactctctat agaatatagt aacctttatg   1881

 aaacggggcc atatagtttg gttatgacat caatatttta cctaggtgaa attgtttagg   1941

 cttatgtacc ttcgttcaaa tatcctcatg taattgccat ctgtcactca ctatattcac   2001

 aaaaataaaa ctctacaact cattttaaca ttggttactt taaagctaca tagccccatc   2061

 gaaatgcgag gattaatgct ttaatgcttt taaagacagg gtctccctgt gttgcccagg   2121

 ctggtttcaa actcccccaa atggactttt tattcatttt atggaaaaga ctaggctttg   2181

 cttagtatca tgtccatgtt tccttcacct cagtggagct tctgagtttt atactgctca   2241

 agatcgtcat aaataaaatt ttttctcatt aaaaaaaaaa aa                      2283




      <210> 148
      <211> 3089
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (79)..(2571)

      <400> 148
 ggaattcgca ctgtcaagaa tgagttctcc ctcaagacct tcaagaggaa gtccgaggtg     60

 gatcgtgctg tcaagagg  atg cgg cat ctg tcc acg ggc acc atg acc ggg     111
                      Met Arg His Leu Ser Thr Gly Thr Met Thr Gly
                        1               5                  10

 ctg gcc atc cag tat gcc ctg aac atc gca ttc tca gaa gca gag ggg      159
 Leu Ala Ile Gln Tyr Ala Leu Asn Ile Ala Phe Ser Glu Ala Glu Gly
              15                  20                  25

 gcc cgg ccc ctg agg cag aat gtg cca cgg gtc ata atg atc gtg aca      207
 Ala Arg Pro Leu Arg Gln Asn Val Pro Arg Val Ile Met Ile Val Thr
          30                  35                  40

 gat ggg aga cct cag gac tcc gtg gcc gag gtg gct gct aag gca cgg      255
 Asp Gly Arg Pro Gln Asp Ser Val Ala Glu Val Ala Ala Lys Ala Arg
      45                  50                  55

 gac acg ggc atc cta atc ttt gcc att ggt gtg ggc cag gta gac ttc      303
 Asp Thr Gly Ile Leu Ile Phe Ala Ile Gly Val Gly Gln Val Asp Phe
  60                  65                  70                  75

 aac acc ttg aag tcc att ggg agt gag ccc cat gag gac cat gtc ttc      351
 Asn Thr Leu Lys Ser Ile Gly Ser Glu Pro His Glu Asp His Val Phe
                  80                  85                  90

 ctt gtg gcc aat ttc agc cag att gag acg ctg acc tcc gtg ttc cag      399
 Leu Val Ala Asn Phe Ser Gln Ile Glu Thr Leu Thr Ser Val Phe Gln
              95                 100                 105

 aag aag ttg tgc acg gcc cac atg tgc agc acc ctg gag cat aac tgt      447
 Lys Lys Leu Cys Thr Ala His Met Cys Ser Thr Leu Glu His Asn Cys
         110                 115                 120

 gcc cac ttc tgc atc aac atc cct ggc tca tac gtc tgc agg tgc aaa      495
 Ala His Phe Cys Ile Asn Ile Pro Gly Ser Tyr Val Cys Arg Cys Lys
     125                 130                 135

 caa ggc tac att ctc aac tcg gat cag acg act tgc aga atc cag gat      543
 Gln Gly Tyr Ile Leu Asn Ser Asp Gln Thr Thr Cys Arg Ile Gln Asp
 140                 145                 150                 155

 ctg tgt gcc atg gag gac cac aac tgt gag cag ctc tgt gtg aat gtg      591
 Leu Cys Ala Met Glu Asp His Asn Cys Glu Gln Leu Cys Val Asn Val
                 160                 165                 170

 ccg ggc tcc ttc gtc tgc cag tgc tac agt ggc tac gcc ctg gct gag      639
 Pro Gly Ser Phe Val Cys Gln Cys Tyr Ser Gly Tyr Ala Leu Ala Glu
             175                 180                 185

 gat ggg aag agg tgt gtg gct gtg gac tac tgt gcc tca gaa aac cac      687
 Asp Gly Lys Arg Cys Val Ala Val Asp Tyr Cys Ala Ser Glu Asn His
         190                 195                 200

 gga tgt gaa cat gag tgt gta aat gct gat ggc tcc tac ctt tgc cag      735
 Gly Cys Glu His Glu Cys Val Asn Ala Asp Gly Ser Tyr Leu Cys Gln
     205                 210                 215

 tgc cat gaa gga ttt gct ctt aac cca gat aaa aaa acg tgc aca aag      783
 Cys His Glu Gly Phe Ala Leu Asn Pro Asp Lys Lys Thr Cys Thr Lys
 220                 225                 230                 235

 ata gac tac tgt gcc tca tct aat cac gga tgt cag cac gag tgt gtt      831
 Ile Asp Tyr Cys Ala Ser Ser Asn His Gly Cys Gln His Glu Cys Val
                 240                 245                 250

 aac aca gat gat tcc tat tcc tgc cac tgc ctg aaa ggc ttt acc ctg      879
 Asn Thr Asp Asp Ser Tyr Ser Cys His Cys Leu Lys Gly Phe Thr Leu
             255                 260                 265

 aat cca gat aag aaa acc tgc aga agg atc aac tac tgt gca ctg aac      927
 Asn Pro Asp Lys Lys Thr Cys Arg Arg Ile Asn Tyr Cys Ala Leu Asn
         270                 275                 280

 aaa ccg ggc tgt gag cat gag tgc gtc aac atg gag gag agc tac tac      975
 Lys Pro Gly Cys Glu His Glu Cys Val Asn Met Glu Glu Ser Tyr Tyr
     285                 290                 295

 tgc cgc tgc cac cgt ggc tac act ctg gac ccc aat ggc aaa acc tgc     1023
 Cys Arg Cys His Arg Gly Tyr Thr Leu Asp Pro Asn Gly Lys Thr Cys
 300                 305                 310                 315

 agc cga gtg gac cac tgt gca cag cag gac cat ggc tgt gag cag ctg     1071
 Ser Arg Val Asp His Cys Ala Gln Gln Asp His Gly Cys Glu Gln Leu
                 320                 325                 330

 tgt ctg aac acg gag gat tcc ttc gtc tgc cag tgc tca gaa ggc ttc     1119
 Cys Leu Asn Thr Glu Asp Ser Phe Val Cys Gln Cys Ser Glu Gly Phe
             335                 340                 345

 ctc atc aac gag gac ctc aag acc tgc tcc cgg gtg gat tac tgc ctg     1167
 Leu Ile Asn Glu Asp Leu Lys Thr Cys Ser Arg Val Asp Tyr Cys Leu
         350                 355                 360

 ctg agt gac cat ggt tgt gaa tac tcc tgt gtc aac atg gac aga tcc     1215
 Leu Ser Asp His Gly Cys Glu Tyr Ser Cys Val Asn Met Asp Arg Ser
     365                 370                 375

 ttt gcc tgt cag tgt cct gag gga cac gtg ctc cgc agc gat ggg aag     1263
 Phe Ala Cys Gln Cys Pro Glu Gly His Val Leu Arg Ser Asp Gly Lys
 380                 385                 390                 395

 acg tgt gca aaa ttg gac tct tgt gct ctg ggg gac cac ggt tgt gaa     1311
 Thr Cys Ala Lys Leu Asp Ser Cys Ala Leu Gly Asp His Gly Cys Glu
                 400                 405                 410

 cat tcg tgt gta agc agt gaa gat tcg ttt gtg tgc cag tgc ttt gaa     1359
 His Ser Cys Val Ser Ser Glu Asp Ser Phe Val Cys Gln Cys Phe Glu
             415                 420                 425

 ggt tat ata ctc cgt gaa gat gga aaa acc tgc aga agg aaa gat gtc     1407
 Gly Tyr Ile Leu Arg Glu Asp Gly Lys Thr Cys Arg Arg Lys Asp Val
         430                 435                 440

 tgc caa gct ata gac cat ggc tgt gaa cac att tgt gtg aac agt gac     1455
 Cys Gln Ala Ile Asp His Gly Cys Glu His Ile Cys Val Asn Ser Asp
     445                 450                 455

 gac tca tac acg tgc gag tgc ttg gag gga ttc cgg ctc gct gag gat     1503
 Asp Ser Tyr Thr Cys Glu Cys Leu Glu Gly Phe Arg Leu Ala Glu Asp
 460                 465                 470                 475

 ggg aaa cgc tgc cga agg aag gat gtc tgc aaa tca acc cac cat ggc     1551
 Gly Lys Arg Cys Arg Arg Lys Asp Val Cys Lys Ser Thr His His Gly
                 480                 485                 490

 tgc gaa cac att tgt gtt aat aat ggg aat tcc tac atc tgc aaa tgc     1599
 Cys Glu His Ile Cys Val Asn Asn Gly Asn Ser Tyr Ile Cys Lys Cys
             495                 500                 505

 tca gag gga ttt gtt cta gct gag gac gga aga cgg tgc aag aaa tgc     1647
 Ser Glu Gly Phe Val Leu Ala Glu Asp Gly Arg Arg Cys Lys Lys Cys
         510                 515                 520

 act gaa ggc cca att gac ctg gtc ttt gtg atc gat gga tcc aag agt     1695
 Thr Glu Gly Pro Ile Asp Leu Val Phe Val Ile Asp Gly Ser Lys Ser
     525                 530                 535

 ctt gga gaa gag aat ttt gag gtc gtg aag cag ttt gtc act gga att     1743
 Leu Gly Glu Glu Asn Phe Glu Val Val Lys Gln Phe Val Thr Gly Ile
 540                 545                 550                 555

 ata gat tcc ttg aca att tcc ccc aaa gcc gct cga gtg ggg ctg ctc     1791
 Ile Asp Ser Leu Thr Ile Ser Pro Lys Ala Ala Arg Val Gly Leu Leu
                 560                 565                 570

 cag tat tcc aca cag gtc cac aca gag ttc act ctg aga aac ttc aac     1839
 Gln Tyr Ser Thr Gln Val His Thr Glu Phe Thr Leu Arg Asn Phe Asn
             575                 580                 585

 tca gcc aaa gac atg aaa aaa gcc gtg gcc cac atg aaa tac atg gga     1887
 Ser Ala Lys Asp Met Lys Lys Ala Val Ala His Met Lys Tyr Met Gly
         590                 595                 600

 aag ggc tct atg act ggg ctg gcc ctg aaa cac atg ttt gag aga agt     1935
 Lys Gly Ser Met Thr Gly Leu Ala Leu Lys His Met Phe Glu Arg Ser
     605                 610                 615

 ttt acc caa gga gaa ggg gcc agg ccc ctt tcc aca agg gtg ccc aga     1983
 Phe Thr Gln Gly Glu Gly Ala Arg Pro Leu Ser Thr Arg Val Pro Arg
 620                 625                 630                 635

 gca gcc att gtg ttc acc gac gga cgg gct cag gat gac gtc tcc gag     2031
 Ala Ala Ile Val Phe Thr Asp Gly Arg Ala Gln Asp Asp Val Ser Glu
                 640                 645                 650

 tgg gcc agt aaa gcc aag gcc aat ggt atc act atg tat gct gtt ggg     2079
 Trp Ala Ser Lys Ala Lys Ala Asn Gly Ile Thr Met Tyr Ala Val Gly
             655                 660                 665

 gta gga aaa gcc att gag gag gaa cta caa gag att gcc tct gag ccc     2127
 Val Gly Lys Ala Ile Glu Glu Glu Leu Gln Glu Ile Ala Ser Glu Pro
         670                 675                 680

 aca aac aag cat ctc ttc tat gcc gaa gac ttc agc aca atg gat gag     2175
 Thr Asn Lys His Leu Phe Tyr Ala Glu Asp Phe Ser Thr Met Asp Glu
     685                 690                 695

 ata agt gaa aaa ctc aag aaa ggc atc tgt gaa gct cta gaa gac tcc     2223
 Ile Ser Glu Lys Leu Lys Lys Gly Ile Cys Glu Ala Leu Glu Asp Ser
 700                 705                 710                 715

 gat gga aga cag gac tct cca gca ggg gaa ctg cca aaa acg gtc caa     2271
 Asp Gly Arg Gln Asp Ser Pro Ala Gly Glu Leu Pro Lys Thr Val Gln
                 720                 725                 730

 cag cca aca gaa tct gag cca gtc acc ata aat atc caa gac cta ctt     2319
 Gln Pro Thr Glu Ser Glu Pro Val Thr Ile Asn Ile Gln Asp Leu Leu
             735                 740                 745

 tcc tgt tct aat ttt gca gtg caa cac aga tat ctg ttt gaa gaa gac     2367
 Ser Cys Ser Asn Phe Ala Val Gln His Arg Tyr Leu Phe Glu Glu Asp
         750                 755                 760

 aat ctt tta cgg tct aca caa aag ctt tcc cat tca aca aaa cct tca     2415
 Asn Leu Leu Arg Ser Thr Gln Lys Leu Ser His Ser Thr Lys Pro Ser
     765                 770                 775

 gga agc cct ttg gaa gaa aaa cac gat caa tgc aaa tgt gaa aac ctt     2463
 Gly Ser Pro Leu Glu Glu Lys His Asp Gln Cys Lys Cys Glu Asn Leu
 780                 785                 790                 795

 ata atg ttc cag aac ctt gca aac gaa gaa gta aga aaa tta aca cag     2511
 Ile Met Phe Gln Asn Leu Ala Asn Glu Glu Val Arg Lys Leu Thr Gln
                 800                 805                 810

 cgc tta gaa gaa atg aca cag aga atg gaa gcc ctg gaa aat cgc ctg     2559
 Arg Leu Glu Glu Met Thr Gln Arg Met Glu Ala Leu Glu Asn Arg Leu
             815                 820                 825

 aga tac aga tga aga ttagaaatcg cgacacattt gtagtcattg tatcacggat     2614
 Arg Tyr Arg 
         830

 tacaatgaac gcagtgcaga gccccaaagc tcaggctatt gttaaatcaa taatgttgtg   2674

 aagtagaaca atcagtactg agaaacctgg tttgccacag aacaaagaca agaagtatac   2734

 actaacttgt ataaatttat ctaggaaaaa aatccttcag aattctaaga tgaatttacc   2794

 aggtgagaat gaataagcta tgcaaggtat tttgtaatat actgtggaca caacttgctt   2854

 ctgcctcatc ctgccttagt gtgcaatctc atttgactat acgataaagt ttgcacagtc   2914

 ttacttctgt agaacactgg ccataggaaa tgctgttttt ttgtattgga ctttaccttg   2974

 atatatgtat atggatgtat gcataaaatc ataggacata tgtacttgtg gaacaagttg   3034

 gattttttat acaatattaa aattcaccac ttcagagaat ggtaaaaaaa aaaaa        3089




      <210> 149
      <211> 3032
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (79)..(2514)

      <400> 149
 ggaattcgca ctgtcaagaa tgagttctcc ctcaagacct tcaagaggaa gtccgaggtg     60

 gatcgtgctg tcaagagg  atg cgg cat ctg tcc acg ggc acc atg acc ggg     111
                      Met Arg His Leu Ser Thr Gly Thr Met Thr Gly
                        1               5                  10

 ctg gcc atc cag tat gcc ctg aac atc gca ttc tca gaa gca gag ggg      159
 Leu Ala Ile Gln Tyr Ala Leu Asn Ile Ala Phe Ser Glu Ala Glu Gly
              15                  20                  25

 gcc cgg ccc ctg agg cag aat gtg cca cgg gtc ata atg atc gtg aca      207
 Ala Arg Pro Leu Arg Gln Asn Val Pro Arg Val Ile Met Ile Val Thr
          30                  35                  40

 gat ggg aga cct cag gac tcc gtg gcc gag gtg gct gct aag gca cgg      255
 Asp Gly Arg Pro Gln Asp Ser Val Ala Glu Val Ala Ala Lys Ala Arg
      45                  50                  55

 gac acg ggc atc cta atc ttt gcc att ggt gtg ggc cag gta gac ttc      303
 Asp Thr Gly Ile Leu Ile Phe Ala Ile Gly Val Gly Gln Val Asp Phe
  60                  65                  70                  75

 aac acc ttg aag tcc att ggg agt gag ccc cat gag gac cat gtc ttc      351
 Asn Thr Leu Lys Ser Ile Gly Ser Glu Pro His Glu Asp His Val Phe
                  80                  85                  90

 ctt gtg gcc aat ttc agc cag att gag acg ctg acc tcc gtg ttc cag      399
 Leu Val Ala Asn Phe Ser Gln Ile Glu Thr Leu Thr Ser Val Phe Gln
              95                 100                 105

 aag aag ttg tgc acg gcc cac atg tgc agc acc ctg gag cat aac tgt      447
 Lys Lys Leu Cys Thr Ala His Met Cys Ser Thr Leu Glu His Asn Cys
         110                 115                 120

 gcc cac ttc tgc atc aac atc cct ggc tca tac gtc tgc agg tgc aaa      495
 Ala His Phe Cys Ile Asn Ile Pro Gly Ser Tyr Val Cys Arg Cys Lys
     125                 130                 135

 caa ggc tac att ctc aac tcg gat cag acg act tgc aga atc cag gat      543
 Gln Gly Tyr Ile Leu Asn Ser Asp Gln Thr Thr Cys Arg Ile Gln Asp
 140                 145                 150                 155

 ctg tgt gcc atg gag gac cac aac tgt gag cag ctc tgt gtg aat gtg      591
 Leu Cys Ala Met Glu Asp His Asn Cys Glu Gln Leu Cys Val Asn Val
                 160                 165                 170

 ccg ggc tcc ttc gtc tgc cag tgc tac agt ggc tac gcc ctg gct gag      639
 Pro Gly Ser Phe Val Cys Gln Cys Tyr Ser Gly Tyr Ala Leu Ala Glu
             175                 180                 185

 gat ggg aag agg tgt gtg gct gtg gac tac tgt gcc tca gaa aac cac      687
 Asp Gly Lys Arg Cys Val Ala Val Asp Tyr Cys Ala Ser Glu Asn His
         190                 195                 200

 gga tgt gaa cat gag tgt gta aat gct gat ggc tcc tac ctt tgc cag      735
 Gly Cys Glu His Glu Cys Val Asn Ala Asp Gly Ser Tyr Leu Cys Gln
     205                 210                 215

 tgc cat gaa gga ttt gct ctt aac cca gat aaa aaa acg tgc aca aag      783
 Cys His Glu Gly Phe Ala Leu Asn Pro Asp Lys Lys Thr Cys Thr Lys
 220                 225                 230                 235

 ata gac tac tgt gcc tca tct aat cac gga tgt cag cac gag tgt gtt      831
 Ile Asp Tyr Cys Ala Ser Ser Asn His Gly Cys Gln His Glu Cys Val
                 240                 245                 250

 aac aca gat gat tcc tat tcc tgc cac tgc ctg aaa ggc ttt acc ctg      879
 Asn Thr Asp Asp Ser Tyr Ser Cys His Cys Leu Lys Gly Phe Thr Leu
             255                 260                 265

 aat cca gat aag aaa acc tgc aga agg atc aac tac tgt gca ctg aac      927
 Asn Pro Asp Lys Lys Thr Cys Arg Arg Ile Asn Tyr Cys Ala Leu Asn
         270                 275                 280

 aaa ccg ggc tgt gag cat gag tgc gtc aac atg gag gag agc tac tac      975
 Lys Pro Gly Cys Glu His Glu Cys Val Asn Met Glu Glu Ser Tyr Tyr
     285                 290                 295

 tgc cgc tgc cac cgt ggc tac act ctg gac ccc aat ggc aaa acc tgc     1023
 Cys Arg Cys His Arg Gly Tyr Thr Leu Asp Pro Asn Gly Lys Thr Cys
 300                 305                 310                 315

 agc cga gtg gac cac tgt gca cag cag gac cat ggc tgt gag cag ctg     1071
 Ser Arg Val Asp His Cys Ala Gln Gln Asp His Gly Cys Glu Gln Leu
                 320                 325                 330

 tgt ctg aac acg gag gat tcc ttc gtc tgc cag tgc tca gaa ggc ttc     1119
 Cys Leu Asn Thr Glu Asp Ser Phe Val Cys Gln Cys Ser Glu Gly Phe
             335                 340                 345

 ctc atc aac gag gac ctc aag acc tgc tcc cgg gtg gat tac tgc ctg     1167
 Leu Ile Asn Glu Asp Leu Lys Thr Cys Ser Arg Val Asp Tyr Cys Leu
         350                 355                 360

 ctg agt gac cat ggt tgt gaa tac tcc tgt gtc aac atg gac aga tcc     1215
 Leu Ser Asp His Gly Cys Glu Tyr Ser Cys Val Asn Met Asp Arg Ser
     365                 370                 375

 ttt gcc tgt cag tgt cct gag gga cac gtg ctc cgc agc gat ggg aag     1263
 Phe Ala Cys Gln Cys Pro Glu Gly His Val Leu Arg Ser Asp Gly Lys
 380                 385                 390                 395

 acg tgt gca aaa ttg gac tct tgt gct ctg ggg gac cac ggt tgt gaa     1311
 Thr Cys Ala Lys Leu Asp Ser Cys Ala Leu Gly Asp His Gly Cys Glu
                 400                 405                 410

 cat tcg tgt gta agc agt gaa gat tcg ttt gtg tgc cag tgc ttt gaa     1359
 His Ser Cys Val Ser Ser Glu Asp Ser Phe Val Cys Gln Cys Phe Glu
             415                 420                 425

 ggt tat ata ctc cgt gaa gat gga aaa acc tgc aga agg aaa gat gtc     1407
 Gly Tyr Ile Leu Arg Glu Asp Gly Lys Thr Cys Arg Arg Lys Asp Val
         430                 435                 440

 tgc caa gct ata gac cat ggc tgt gaa cac att tgt gtg aac agt gac     1455
 Cys Gln Ala Ile Asp His Gly Cys Glu His Ile Cys Val Asn Ser Asp
     445                 450                 455

 gac tca tac acg tgc gag tgc ttg gag gga ttc cgg ctc gct gag gat     1503
 Asp Ser Tyr Thr Cys Glu Cys Leu Glu Gly Phe Arg Leu Ala Glu Asp
 460                 465                 470                 475

 ggg aaa cgc tgc cga agg aag gat gtc tgc aaa tca acc cac cat ggc     1551
 Gly Lys Arg Cys Arg Arg Lys Asp Val Cys Lys Ser Thr His His Gly
                 480                 485                 490

 tgc gaa cac att tgt gtt aat aat ggg aat tcc tac atc tgc aaa tgc     1599
 Cys Glu His Ile Cys Val Asn Asn Gly Asn Ser Tyr Ile Cys Lys Cys
             495                 500                 505

 tca gag gga ttt gtt cta gct gag gac gga aga cgg tgc aag aaa tgc     1647
 Ser Glu Gly Phe Val Leu Ala Glu Asp Gly Arg Arg Cys Lys Lys Cys
         510                 515                 520

 act gaa ggc cca att gac ctg gtc ttt gtg atc gat gga tcc aag agt     1695
 Thr Glu Gly Pro Ile Asp Leu Val Phe Val Ile Asp Gly Ser Lys Ser
     525                 530                 535

 ctt gga gaa gag aat ttt gag gtc gtg aag cag ttt gtc act gga att     1743
 Leu Gly Glu Glu Asn Phe Glu Val Val Lys Gln Phe Val Thr Gly Ile
 540                 545                 550                 555

 ata gat tcc ttg aca att tcc ccc aaa gcc gct cga gtg ggg ctg ctc     1791
 Ile Asp Ser Leu Thr Ile Ser Pro Lys Ala Ala Arg Val Gly Leu Leu
                 560                 565                 570

 cag tat tcc aca cag gtc cac aca gag ttc act ctg aga aac ttc aac     1839
 Gln Tyr Ser Thr Gln Val His Thr Glu Phe Thr Leu Arg Asn Phe Asn
             575                 580                 585

 tca gcc aaa gac atg aaa aaa gcc gtg gcc cac atg aaa tac atg gga     1887
 Ser Ala Lys Asp Met Lys Lys Ala Val Ala His Met Lys Tyr Met Gly
         590                 595                 600

 aag ggc tct atg act ggg ctg gcc ctg aaa cac atg ttt gag aga agt     1935
 Lys Gly Ser Met Thr Gly Leu Ala Leu Lys His Met Phe Glu Arg Ser
     605                 610                 615

 ttt acc caa gga gaa ggg gcc agg ccc ctt tcc aca agg gtg ccc aga     1983
 Phe Thr Gln Gly Glu Gly Ala Arg Pro Leu Ser Thr Arg Val Pro Arg
 620                 625                 630                 635

 gca gcc att gtg ttc acc gac gga cgg gct cag gat gac gtc tcc gag     2031
 Ala Ala Ile Val Phe Thr Asp Gly Arg Ala Gln Asp Asp Val Ser Glu
                 640                 645                 650

 tgg gcc agt aaa gcc aag gcc aat ggt atc act atg tat gct gtt ggg     2079
 Trp Ala Ser Lys Ala Lys Ala Asn Gly Ile Thr Met Tyr Ala Val Gly
             655                 660                 665

 gta gga aaa gcc att gag gag gaa cta caa gag att gcc tct gag ccc     2127
 Val Gly Lys Ala Ile Glu Glu Glu Leu Gln Glu Ile Ala Ser Glu Pro
         670                 675                 680

 aca aac aag cat ctc ttc tat gcc gaa gac ttc agc aca atg gat gag     2175
 Thr Asn Lys His Leu Phe Tyr Ala Glu Asp Phe Ser Thr Met Asp Glu
     685                 690                 695

 ata agt gaa aaa ctc aag aaa ggc atc tgt gaa gct cta gaa gac tcc     2223
 Ile Ser Glu Lys Leu Lys Lys Gly Ile Cys Glu Ala Leu Glu Asp Ser
 700                 705                 710                 715

 gat gga aga cag gac tct cca gca ggg gaa ctg cca aaa acg gtc caa     2271
 Asp Gly Arg Gln Asp Ser Pro Ala Gly Glu Leu Pro Lys Thr Val Gln
                 720                 725                 730

 cag cca aca gtg caa cac aga tat ctg ttt gaa gaa gac aat ctt tta     2319
 Gln Pro Thr Val Gln His Arg Tyr Leu Phe Glu Glu Asp Asn Leu Leu
             735                 740                 745

 cgg tct aca caa aag ctt tcc cat tca aca aaa cct tca gga agc cct     2367
 Arg Ser Thr Gln Lys Leu Ser His Ser Thr Lys Pro Ser Gly Ser Pro
         750                 755                 760

 ttg gaa gaa aaa cac gat caa tgc aaa tgt gaa aac ctt ata atg ttc     2415
 Leu Glu Glu Lys His Asp Gln Cys Lys Cys Glu Asn Leu Ile Met Phe
     765                 770                 775

 cag aac ctt gca aac gaa gaa gta aga aaa tta aca cag cgc tta gaa     2463
 Gln Asn Leu Ala Asn Glu Glu Val Arg Lys Leu Thr Gln Arg Leu Glu
 780                 785                 790                 795

 gaa atg aca cag aga atg gaa gcc ctg gaa aat cgc ctg aga tac aga     2511
 Glu Met Thr Gln Arg Met Glu Ala Leu Glu Asn Arg Leu Arg Tyr Arg
                 800                 805                 810

 tga agat tagaaatcgc gacacatttg tagtcattgt atcacggatt acaatgaacg     2568
 


 cagtgcagag ccccaaagct caggctattg ttaaatcaat aatgttgtga agtagaacaa   2628

 tcagtactga gaaacctggt ttgccacaga acaaagacaa gaagtataca ctaacttgta   2688

 taaatttatc taggaaaaaa atccttcaga attctaagat gaatttacca ggtgagaatg   2748

 aataagctat gcaaggtatt ttgtaatata ctgtggacac aacttgcttc tgcctcatcc   2808

 tgccttagtg tgcaatctca tttgactata cgataaagtt tgcacagtct tacttctgta   2868

 gaacactggc cataggaaat gctgtttttt tgtattggac tttaccttga tatatgtata   2928

 tggatgtatg cataaaatca taggacatat gtacttgtgg aacaagttgg attttttata   2988

 caatattaaa attcaccact tcagagaatg gtaaaaaaaa aaaa                    3032




      <210> 150
      <211> 2517
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1673)..(2095)

      <400> 150
 gcacgagcac aaagccagtt tttcgggggg atgctcagtg tctacctgca gtgccaaagt     60

 tttgcttgaa cagccctctt ctgccgcgcc tcccagctcc accccctatc aacgtgggtg    120

 ctggctgctt ctgcgtgagg agcttcctct gatcacctgt agcatcttta gtgccttcgt    180

 ccagtcggcc tgcaaatccc atttcccaga gaggcttggg cagggcccac ttgccacttg    240

 gccctgtgcc cagagcgttg ggggcagatg gcagccaggg gaagaaggga ggtggggaag    300

 ggccgccacc gcttgagggt cccctccctt gagaggaggc cccatggcag ttttcctgag    360

 ttcttgatcc actttggttt aaacaacttt tgtgaagcta tgtgagattt gactgcattt    420

 caaaagacaa aacacatgtt tttttctgat ttgctctttg cctttcagcg acgctttcag    480

 atactttgtg agtgtctact ctgtgctagg tgctgagtag actgggatgt gtgtggctcc    540

 atccctggct ggaagagctt tgagtcctgt ctgctgactt cactgaagga gtttctctct    600

 tgcttcattc cttcctcccg ggggtcagct gggtaggagc agacttgccc tgccttcctc    660

 taggcagaaa gttttcctgc aaatgaaaga atctgccatt ctcttttgct atgatgatga    720

 tgattattct gacatgaccc gcgggtactg aagccacagt cctctctgtt cactgttctc    780

 tccttgagtc atatctatgg cctgaggacg tctgtatcca gctccttttc ctacaatggt    840

 agacacttcc ccaggcagtg ggtgggtcgg ggtggccagt cactctccta gctgtccttg    900

 cctggggact tagatttacc ccatccagga ctgtggtcgc tattctgtga gcgattgatg    960

 gcgcatatgc agaactcccc tggagtcatg gctctagaaa gtgtccaggc ccatcgtgac   1020

 aatggtgcca agcaccgggc tggtgaccag tgcctaaaca cacacgctcc cttaatcctt   1080

 acggcaagcc tgtgaggcgg ataggaccag ccctgatcta tagtgagaaa attaaggttc   1140

 agagggagaa ggtccaaata gtggccaagc tgggactgag atctcgagtt tgggtttgtt   1200

 tgggttttgt tgttgttgtt ctttccctcg tgtccatgac ttttctctgc cattagcagg   1260

 gaagtgtgcg gagggcttcc agggaatcaa gtgaccctcc ctctgaattt cggtgcctct   1320

 tccccccgcc ccttgctcac acatttcagt aggtcacagg ccaaatggca gcccaaaagg   1380

 tgggcagaga tttttttttc ttcccctcac ccctgcttat taacacaatt gtgacaacta   1440

 ctttacctta catcccaggg caaacggaca gcttgcggta cctccaaaaa tttggaaaac   1500

 cctgagtcta agaccacctc ttgataaaag aggcctttgc tcacattttc tgctcggaat   1560

 ctttctttgc cattggtggg tgtatgtcgt cccagctgag actgcgggag agctgagctc   1620

 cagcttaaac cgcttttaat ggcccttccc tactggggga tcgctggagc cc    atg    1675
                                                              Met
                                                                1

 cca ggt tac ggt agt cat ttt aaa cct ctg cca caa ggc cac gcc ata     1723
 Pro Gly Tyr Gly Ser His Phe Lys Pro Leu Pro Gln Gly His Ala Ile
               5                  10                  15

 gaa tca att tcc aag tca atg ttc ttg gcc cta aaa tgt ttg cgc cca     1771
 Glu Ser Ile Ser Lys Ser Met Phe Leu Ala Leu Lys Cys Leu Arg Pro
          20                  25                  30

 ctg agg att tca tta cca ggt gga aga tgg ggg aac ata tgc cac gtt     1819
 Leu Arg Ile Ser Leu Pro Gly Gly Arg Trp Gly Asn Ile Cys His Val
      35                  40                  45

 aaa gag caa gtg ctg agt gtg cca gga ctt gag aag gac ctt agg ctg     1867
 Lys Glu Gln Val Leu Ser Val Pro Gly Leu Glu Lys Asp Leu Arg Leu
  50                  55                  60                  65

 agg agt gga cag tct ggt att tat ttc gcc tct ccc aag tac cca gca     1915
 Arg Ser Gly Gln Ser Gly Ile Tyr Phe Ala Ser Pro Lys Tyr Pro Ala
                  70                  75                  80

 cag agt ggg aaa aag aag aaa ctg ctc ctg cct tcc agt agc tgg caa     1963
 Gln Ser Gly Lys Lys Lys Lys Leu Leu Leu Pro Ser Ser Ser Trp Gln
              85                  90                  95

 ctt gac atc aag aac aaa aac att cgt agc tgg acc ccc gtc ctt tca     2011
 Leu Asp Ile Lys Asn Lys Asn Ile Arg Ser Trp Thr Pro Val Leu Ser
         100                 105                 110

 tcg tgc cca agt ctt aca tgt tgg ctt aag ctg ccc cct tgg agg ccg     2059
 Ser Cys Pro Ser Leu Thr Cys Trp Leu Lys Leu Pro Pro Trp Arg Pro
     115                 120                 125

 tac ctt tct ctt tgg act gtg aca gtg gac acc taa cagc ctgagccatg     2109
 Tyr Leu Ser Leu Trp Thr Val Thr Val Asp Thr 
 130                 135                 140

 tgtggctgtc ttatccccca agggttgtcc aggcccgttc tgcagggctg ttgtgtagac   2169

 tgcagacatc catacctcac cacagaccaa agatgacctc gtgtcagact gtgggctgat   2229

 gagaggtaga gcagcatgca tcgaggcctg agggtgcagg gcgccctctc ttggcctgga   2289

 ggaattgctc ctaactagag taagtttcca cgagggtccc aggcagagct gcagagctgg   2349

 aaccggaggc tccacagtcc ttgcctgctc atggacctcc ttcagagcac ctttctacag   2409

 actggactgc ccagctccgt ggggtggcat ctggtttctg gtgctattct gccaagttat   2469

 cgagctcctc ctcatgtttc aacattccat cttcccggtt ctatcctc                2517




      <210> 151
      <211> 748
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (166)..(672)

      <400> 151
 aagaattcgg cacgaggctc ccaagtcctg gaacgggcct ccccaccctc cggggcaccg     60

 acactcacgg agtcactcca acttctctgg gtgctccgtg gacgaagagc gctctaggac    120

 aagcaaggat tcctcttctc ctgtaaatga ccacagagga agaca    atg aat gag     174
                                                      Met Asn Glu
                                                        1

 gtg aaa gaa tcc ctt cgc agc atc gag cag aag tac aag ctc ttc cag      222
 Val Lys Glu Ser Leu Arg Ser Ile Glu Gln Lys Tyr Lys Leu Phe Gln
       5                  10                  15

 cag cag cag ctc acc ttc acc gcc gct ctg gag cac tgc agg gag aac      270
 Gln Gln Gln Leu Thr Phe Thr Ala Ala Leu Glu His Cys Arg Glu Asn
  20                  25                  30                  35

 gcc cac gac aag atc cgg ccc atc tcc agc att gga cag gtg cag agc      318
 Ala His Asp Lys Ile Arg Pro Ile Ser Ser Ile Gly Gln Val Gln Ser
                  40                  45                  50

 tac atg gaa cac tac tgc aac agc tcc aca gac cgg cgg gtt ctg ctc      366
 Tyr Met Glu His Tyr Cys Asn Ser Ser Thr Asp Arg Arg Val Leu Leu
              55                  60                  65

 atg ttc ctg gac atc tgt tca gag ctg aat aag ctc tgc cag cac ttt      414
 Met Phe Leu Asp Ile Cys Ser Glu Leu Asn Lys Leu Cys Gln His Phe
          70                  75                  80

 gag gcc gtg cac tct ggc acc cca gtc acc aac aac ctc ctg gag aaa      462
 Glu Ala Val His Ser Gly Thr Pro Val Thr Asn Asn Leu Leu Glu Lys
      85                  90                  95

 tgc aaa acc ctc gtt agc caa agc aac gac tta agc agc ctc aga gca      510
 Cys Lys Thr Leu Val Ser Gln Ser Asn Asp Leu Ser Ser Leu Arg Ala
 100                 105                 110                 115

 aaa tac cct cat gat gtg gtg aac cac ctc agc tgt gac gag gcc cgg      558
 Lys Tyr Pro His Asp Val Val Asn His Leu Ser Cys Asp Glu Ala Arg
                 120                 125                 130

 aac cac tac ggc ggc gtg gtc agc ctc atc ccc ctc atc cta gac tta      606
 Asn His Tyr Gly Gly Val Val Ser Leu Ile Pro Leu Ile Leu Asp Leu
             135                 140                 145

 atg aaa gaa tgg atc gcc cac tcc gag aag ttg ccg cgc aag gtg ctg      654
 Met Lys Glu Trp Ile Ala His Ser Glu Lys Leu Pro Arg Lys Val Leu
         150                 155                 160

 cag cac ggg acg act tag cttctg tattattgtt gcttcctcag ggggagacag      708
 Gln His Gly Thr Thr 
     165

 tcaagaataa aaagtattct accacctaaa aaaaaaaaaa                          748




      <210> 152
      <211> 2976
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (223)..(2850)

      <400> 152
 ggggtgacgc aggcgcagcg cgggctgcgc gcgctactgc ccatccccgg ttgtcccact     60

 tttgttcgcc tctcttcggt cctctactca agagctccgt ctccgtctcg ccctcctcga    120

 agtcctcgtc gcgcgcccgc gacccaggtc gccctgaaat ctagcccgtc cgagcgcgag    180

 tccaacggcc gcggccgcac caaggccccc tcagaccgtg cc   atg ggt gac agt     234
                                                  Met Gly Asp Ser
                                                    1

 gat gac gag tac gat cga agg cgc agg gac aag ttc aga aga gag cgc      282
 Asp Asp Glu Tyr Asp Arg Arg Arg Arg Asp Lys Phe Arg Arg Glu Arg
   5                  10                  15                  20

 agc gac tac gac cgt tcc cgc gag aga gat gaa aga cgt cga ggg gac      330
 Ser Asp Tyr Asp Arg Ser Arg Glu Arg Asp Glu Arg Arg Arg Gly Asp
                  25                  30                  35

 gat tgg aat gac aga gag tgg gac cgt ggc cgt gag cgc cgt agt cgg      378
 Asp Trp Asn Asp Arg Glu Trp Asp Arg Gly Arg Glu Arg Arg Ser Arg
              40                  45                  50

 ggt gaa tat cgg gac tat gac cgg aat cgg cga gag cgc ttc tcg cca      426
 Gly Glu Tyr Arg Asp Tyr Asp Arg Asn Arg Arg Glu Arg Phe Ser Pro
          55                  60                  65

 cct cgc cac gaa ctc agc ccg cca cag aag cgc atg agg aga gac tgg      474
 Pro Arg His Glu Leu Ser Pro Pro Gln Lys Arg Met Arg Arg Asp Trp
      70                  75                  80

 gat gag cac agc tct gac cca tac cac agt ggc tat gag atg ccc tat      522
 Asp Glu His Ser Ser Asp Pro Tyr His Ser Gly Tyr Glu Met Pro Tyr
  85                  90                  95                 100

 gct ggg ggg ggt ggg ggc cca act tat ggc ccc cct cag ccc tgg ggc      570
 Ala Gly Gly Gly Gly Gly Pro Thr Tyr Gly Pro Pro Gln Pro Trp Gly
                 105                 110                 115

 cac cct gac gtc cac atc atg cag cac cat gtc ctg cct atc cag gcc      618
 His Pro Asp Val His Ile Met Gln His His Val Leu Pro Ile Gln Ala
             120                 125                 130

 agg ctg ggc agc att gca gag att gac ctg ggt gtg ccg ccg ccc gtg      666
 Arg Leu Gly Ser Ile Ala Glu Ile Asp Leu Gly Val Pro Pro Pro Val
         135                 140                 145

 atg aag acc ttc aag gag ttt ctc ctc tcc ctg gat gac tcg gtg gat      714
 Met Lys Thr Phe Lys Glu Phe Leu Leu Ser Leu Asp Asp Ser Val Asp
     150                 155                 160

 gag acg gag gcc gtc aag cgc tat aat gac tac aag ctg gat ttc cgg      762
 Glu Thr Glu Ala Val Lys Arg Tyr Asn Asp Tyr Lys Leu Asp Phe Arg
 165                 170                 175                 180

 agg caa cag atg cag gat ttc ttc ctg gcg cac aaa gat gag gag tgg      810
 Arg Gln Gln Met Gln Asp Phe Phe Leu Ala His Lys Asp Glu Glu Trp
                 185                 190                 195

 ttt cgg tct aag tac cac cca gat gag gtg ggg aag cgt cgg cag gag      858
 Phe Arg Ser Lys Tyr His Pro Asp Glu Val Gly Lys Arg Arg Gln Glu
             200                 205                 210

 gcc cgg ggg gcc ctg caa aac cga ctg agg gtc ttc ctg tcc ctc atg      906
 Ala Arg Gly Ala Leu Gln Asn Arg Leu Arg Val Phe Leu Ser Leu Met
         215                 220                 225

 gag act ggc tgg ttt gat aac ctt ctc ctg gac ata gac aaa gct gat      954
 Glu Thr Gly Trp Phe Asp Asn Leu Leu Leu Asp Ile Asp Lys Ala Asp
     230                 235                 240

 gcc att gtc aag atg ctg gat gca gcc gtg att aag atg gaa gga ggc     1002
 Ala Ile Val Lys Met Leu Asp Ala Ala Val Ile Lys Met Glu Gly Gly
 245                 250                 255                 260

 acg gag aat gat ctc cgc atc ctg gag cag gag gag gag gag gag cag     1050
 Thr Glu Asn Asp Leu Arg Ile Leu Glu Gln Glu Glu Glu Glu Glu Gln
                 265                 270                 275

 gca gga aag cct ggg gag ccc agc aag aaa gaa gaa gga cgg gct gga     1098
 Ala Gly Lys Pro Gly Glu Pro Ser Lys Lys Glu Glu Gly Arg Ala Gly
             280                 285                 290

 gca ggc cta ggg gac ggg gag cgc aaa acc aac gac aag gat gag aag     1146
 Ala Gly Leu Gly Asp Gly Glu Arg Lys Thr Asn Asp Lys Asp Glu Lys
         295                 300                 305

 aag gaa gac ggc aag cag gct gag aat gac agt tct aat gat gac aaa     1194
 Lys Glu Asp Gly Lys Gln Ala Glu Asn Asp Ser Ser Asn Asp Asp Lys
     310                 315                 320

 aca aag aag tcg gag ggt gat ggg gac aag gaa gag aag aaa gaa gac     1242
 Thr Lys Lys Ser Glu Gly Asp Gly Asp Lys Glu Glu Lys Lys Glu Asp
 325                 330                 335                 340

 tcc gag aag gaa gcc aaa aag agt agc aag aag cgg aac cgg aag cac     1290
 Ser Glu Lys Glu Ala Lys Lys Ser Ser Lys Lys Arg Asn Arg Lys His
                 345                 350                 355

 agt ggt gac gac agc ttt gac gag ggc agc gtg tca gag tct gag tcg     1338
 Ser Gly Asp Asp Ser Phe Asp Glu Gly Ser Val Ser Glu Ser Glu Ser
             360                 365                 370

 gag tca gag agc ggc cag gct gag gag gag aag gag gag gcc gaa gcg     1386
 Glu Ser Glu Ser Gly Gln Ala Glu Glu Glu Lys Glu Glu Ala Glu Ala
         375                 380                 385

 ctc aag gag aag gag aag ccc aag gaa gaa gaa tgg gag aag ccc aag     1434
 Leu Lys Glu Lys Glu Lys Pro Lys Glu Glu Glu Trp Glu Lys Pro Lys
     390                 395                 400

 gac gcc gcg ggg ctg gag tgc aag ccg cgg ccg ctg cat aag acc tgc     1482
 Asp Ala Ala Gly Leu Glu Cys Lys Pro Arg Pro Leu His Lys Thr Cys
 405                 410                 415                 420

 tcc ctc ttc atg cgc aac atc gcg ccc aac atc tcc cgg gcc gag atc     1530
 Ser Leu Phe Met Arg Asn Ile Ala Pro Asn Ile Ser Arg Ala Glu Ile
                 425                 430                 435

 atc tcc ctt tgt aaa agg tac cca ggc ttt atg cgg gtg gcg ctc tca     1578
 Ile Ser Leu Cys Lys Arg Tyr Pro Gly Phe Met Arg Val Ala Leu Ser
             440                 445                 450

 gag ccc cag cca gag agg agg ttt ttc cgt cgt ggc tgg gtg acc ttc     1626
 Glu Pro Gln Pro Glu Arg Arg Phe Phe Arg Arg Gly Trp Val Thr Phe
         455                 460                 465

 gac cgc agt gtt aac att aaa gag atc tgt tgg aac ctg cag aac atc     1674
 Asp Arg Ser Val Asn Ile Lys Glu Ile Cys Trp Asn Leu Gln Asn Ile
     470                 475                 480

 cgt ctc cgg gag tgt gag ctg agc cct ggt gtg aac agg gac ctg acc     1722
 Arg Leu Arg Glu Cys Glu Leu Ser Pro Gly Val Asn Arg Asp Leu Thr
 485                 490                 495                 500

 cgg cgc gtt cgc aac atc aac ggc atc acc cag cac aag cag att gtg     1770
 Arg Arg Val Arg Asn Ile Asn Gly Ile Thr Gln His Lys Gln Ile Val
                 505                 510                 515

 cgc aac gac atc aag ctg gcg gcc aag ctg atc cac acg ctg gat gac     1818
 Arg Asn Asp Ile Lys Leu Ala Ala Lys Leu Ile His Thr Leu Asp Asp
             520                 525                 530

 agg aca cag ctt tgg gcc tca gaa cca ggg acg cct ccc ctg ccc acg     1866
 Arg Thr Gln Leu Trp Ala Ser Glu Pro Gly Thr Pro Pro Leu Pro Thr
         535                 540                 545

 agc ctg ccc tcg caa aac ccg atc ttg aag aat atc acc gac tac ctg     1914
 Ser Leu Pro Ser Gln Asn Pro Ile Leu Lys Asn Ile Thr Asp Tyr Leu
     550                 555                 560

 atc gag gaa gta agc gcc gag gag gag gag ctg ctg ggg agc agc ggg     1962
 Ile Glu Glu Val Ser Ala Glu Glu Glu Glu Leu Leu Gly Ser Ser Gly
 565                 570                 575                 580

 ggc gct cct cct gag gag cct cct aag gaa ggg aac ccg gca gag atc     2010
 Gly Ala Pro Pro Glu Glu Pro Pro Lys Glu Gly Asn Pro Ala Glu Ile
                 585                 590                 595

 aac gtg gag cgg gat gag aag ttg att aag gtc ttg gac aag ctc ctc     2058
 Asn Val Glu Arg Asp Glu Lys Leu Ile Lys Val Leu Asp Lys Leu Leu
             600                 605                 610

 ctt tac ctg cgc atc gtg cat tcc ttg gat tat tac aac acc tgt gag     2106
 Leu Tyr Leu Arg Ile Val His Ser Leu Asp Tyr Tyr Asn Thr Cys Glu
         615                 620                 625

 tac ccc aac gag gac gag atg ccc aat cgc tgt ggg atc atc cac gtt     2154
 Tyr Pro Asn Glu Asp Glu Met Pro Asn Arg Cys Gly Ile Ile His Val
     630                 635                 640

 cgg ggg ccc atg cca ccc aac cgc atc agt cac ggg gaa gtg ctg gag     2202
 Arg Gly Pro Met Pro Pro Asn Arg Ile Ser His Gly Glu Val Leu Glu
 645                 650                 655                 660

 tgg cag aag act ttt gag gag aag ctc acg ccg ttg ctg agt gtg cgg     2250
 Trp Gln Lys Thr Phe Glu Glu Lys Leu Thr Pro Leu Leu Ser Val Arg
                 665                 670                 675

 gag tca ctc tca gag gaa gag gcc cag aag atg ggg cgc aaa gac cca     2298
 Glu Ser Leu Ser Glu Glu Glu Ala Gln Lys Met Gly Arg Lys Asp Pro
             680                 685                 690

 gag cag gaa gtg gag aag ttc gtc acc tcc aac acg cag gaa ctg ggc     2346
 Glu Gln Glu Val Glu Lys Phe Val Thr Ser Asn Thr Gln Glu Leu Gly
         695                 700                 705

 aag gat aag tgg ctg tgt cct ctc agt ggc aag aaa ttc aag ggt cct     2394
 Lys Asp Lys Trp Leu Cys Pro Leu Ser Gly Lys Lys Phe Lys Gly Pro
     710                 715                 720

 gag ttt gtg cgc aaa cat atc ttc aac aag cat gca gag aaa att gag     2442
 Glu Phe Val Arg Lys His Ile Phe Asn Lys His Ala Glu Lys Ile Glu
 725                 730                 735                 740

 gaa gtg aaa aag gaa gtc gcg ttt ttt aac aac ttc ctc act gat gct     2490
 Glu Val Lys Lys Glu Val Ala Phe Phe Asn Asn Phe Leu Thr Asp Ala
                 745                 750                 755

 aag cgc cca gct ctg cct gag atc aag cca gcc cag cca cct ggc ccc     2538
 Lys Arg Pro Ala Leu Pro Glu Ile Lys Pro Ala Gln Pro Pro Gly Pro
             760                 765                 770

 gcc cag ata ctc ccc cca ggt ttg acc cca gga ctc ccc tac cca cac     2586
 Ala Gln Ile Leu Pro Pro Gly Leu Thr Pro Gly Leu Pro Tyr Pro His
         775                 780                 785

 cag act ccc cag ggc ctg atg ccc tat ggt cag ccc cgg ccc ccg atc     2634
 Gln Thr Pro Gln Gly Leu Met Pro Tyr Gly Gln Pro Arg Pro Pro Ile
     790                 795                 800

 ttg ggc tat gga gct ggt gct gtc cgc cct gca gtc ccc aca gga ggc     2682
 Leu Gly Tyr Gly Ala Gly Ala Val Arg Pro Ala Val Pro Thr Gly Gly
 805                 810                 815                 820

 cct cca tac ccc cat gcc ccg tat ggt gct ggt cga ggg aac tat gat     2730
 Pro Pro Tyr Pro His Ala Pro Tyr Gly Ala Gly Arg Gly Asn Tyr Asp
                 825                 830                 835

 gcc ttc cga ggc cag gga ggt tat cct ggg aaa cct cgc aac agg atg     2778
 Ala Phe Arg Gly Gln Gly Gly Tyr Pro Gly Lys Pro Arg Asn Arg Met
             840                 845                 850

 gtt cgt gga gac cca agg gcc att gtg gaa tat cgg gac ctg gat gcc     2826
 Val Arg Gly Asp Pro Arg Ala Ile Val Glu Tyr Arg Asp Leu Asp Ala
         855                 860                 865

 cca gac gat gtt gat ttc ttt tga gccgtccccc gttcctcagt cctgtatcat    2880
 Pro Asp Asp Val Asp Phe Phe 
     870                 875

 ccatacttgt actaccttgt cctatgaagc tctgagaatt ttttgtacga tcagccttac   2940

 tgctaataaa agcacttcca cagggaaaaa aaaaaa                             2976




      <210> 153
      <211> 751
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (320)..(484)

      <400> 153
 cttcctgacc ctcaacttca gtctggctgg agtcacactg ggctgaggga actatggaca     60

 gcaccaccac agatcacagc cacttgggtg gggctgaagt ccccattttt ttcaccactg    120

 ggctatttct gtaggctgct tggtctaact cagttactcc ttgacctttg gcaacatttc    180

 tgtggcctcg ttctcagggc tgggaaggaa ttggtgccag gggaactggc tctgtggacc    240

 ataaaggtca catagtgtct gctgtgtaaa caggctgggg acagaggggc taaggacacc    300

 tattccttcc ggcataggg atg tca gac cag gcg atc atg gag ctg aac ctg     352
                      Met Ser Asp Gln Ala Ile Met Glu Leu Asn Leu
                        1               5                  10

 ccc acg ggg atc ccc att gtg tat gag ctg aac aag gag ctg aag ccc      400
 Pro Thr Gly Ile Pro Ile Val Tyr Glu Leu Asn Lys Glu Leu Lys Pro
              15                  20                  25

 acc aag ccc atg cag ttc ctg ggt gat gag gaa acg gtg cgg aag gcc      448
 Thr Lys Pro Met Gln Phe Leu Gly Asp Glu Glu Thr Val Arg Lys Ala
          30                  35                  40

 atg gag gct gtg gct gcc cag ggc aag gcc aag tga gggg tgggcttggg      498
 Met Glu Ala Val Ala Ala Gln Gly Lys Ala Lys 
      45                  50

 caataaaggc acctccccca acagcctgga gtccagcgca gccgtgcatg ccaggctcac    558

 accgccatca gctgtgggga ctccagaacc aggggtgcag ccacccaccc tcccccattc    618

 cttactgttt ttcaccaggg ggcaggagct aagttaccca cagtgagttc tttaaggaca    678

 tttaagccag ggttggcaac ctctctagga ttttttgatt taagggaaag ttttggttga    738

 ctcgaaattt ttg                                                       751




      <210> 154
      <211> 1871
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (330)..(1541)

      <400> 154
 gcgggccgcc gtacgcccgg ggctgcggct ctcccgcgtg ggccgcggcc gctcggctcc     60

 gcgggcagcc gcgccgtcct gccccgcgcg cgcgctagcc gctgtcggcc gcaggagccc    120

 cgggaatctg gaggggccgt ggggcggagg gaggggcctg cgggcggaag gcggacgaaa    180

 acagaacgga agacgacaag gaggagccgg aagatgcgga cgagaacgcc gaggaggagc    240

 tgctgcgggg agagcctctg ctgccggcgg ggacccatcg cgtgtgtctg gttcaccctg    300

 acgtcaagtg gggcccgggg aagtcgcag  atg act cga gcc gag tgg cag gtg     353
                                  Met Thr Arg Ala Glu Trp Gln Val
                                    1               5

 gcg gag gcc aca gcg ctg gtg cac acg ctg gac ggc tgg tcc gtg gtg      401
 Ala Glu Ala Thr Ala Leu Val His Thr Leu Asp Gly Trp Ser Val Val
      10                  15                  20

 cag aca atg gtc gtg tcc acc aaa acg ccg gac agg aag ctc atc ttt      449
 Gln Thr Met Val Val Ser Thr Lys Thr Pro Asp Arg Lys Leu Ile Phe
  25                  30                  35                  40

 ggc aaa ggg aac ttt gag cac ctg aca gaa aag atc cga ggg tct cca      497
 Gly Lys Gly Asn Phe Glu His Leu Thr Glu Lys Ile Arg Gly Ser Pro
                  45                  50                  55

 gac atc acg tgc gtc ttc ctg aac gtg gag agg atg gct gcc ccg acc      545
 Asp Ile Thr Cys Val Phe Leu Asn Val Glu Arg Met Ala Ala Pro Thr
              60                  65                  70

 aag aaa gaa ctg gaa gcc gcc tgg ggc gtg gag gtg ttt gac cgc ttc      593
 Lys Lys Glu Leu Glu Ala Ala Trp Gly Val Glu Val Phe Asp Arg Phe
          75                  80                  85

 acg gtc gtc ctg cac atc ttc cgc tgt aac gcc cgc acg aag gag gcc      641
 Thr Val Val Leu His Ile Phe Arg Cys Asn Ala Arg Thr Lys Glu Ala
      90                  95                 100

 cgg ctt cag gtg gcc ctg gcg gag atg ccg ctg cac agg tcg aac ttg      689
 Arg Leu Gln Val Ala Leu Ala Glu Met Pro Leu His Arg Ser Asn Leu
 105                 110                 115                 120

 aaa agg gac gtc gcc cac ctg tac cga gga gtc ggc tcg cgc tac atc      737
 Lys Arg Asp Val Ala His Leu Tyr Arg Gly Val Gly Ser Arg Tyr Ile
                 125                 130                 135

 atg ggg tca gga gaa tcc ttc atg cag ctg cag cag cgt ctc ctg aga      785
 Met Gly Ser Gly Glu Ser Phe Met Gln Leu Gln Gln Arg Leu Leu Arg
             140                 145                 150

 gag aag gag gct aag atc agg aag gcc ttg gac agg ctt cgc aag aag      833
 Glu Lys Glu Ala Lys Ile Arg Lys Ala Leu Asp Arg Leu Arg Lys Lys
         155                 160                 165

 agg cac ctg ctc cgc cgg cag cgg acg agg cgg gag ttc ccc gtg atc      881
 Arg His Leu Leu Arg Arg Gln Arg Thr Arg Arg Glu Phe Pro Val Ile
     170                 175                 180

 tcc gtg gtg ggg tac acc aac tgc gga aag acc acg ctg atc aag gca      929
 Ser Val Val Gly Tyr Thr Asn Cys Gly Lys Thr Thr Leu Ile Lys Ala
 185                 190                 195                 200

 ctg acg ggc gat gcc gcc atc cag cca cgg gac cag ctg ttt gcc acg      977
 Leu Thr Gly Asp Ala Ala Ile Gln Pro Arg Asp Gln Leu Phe Ala Thr
                 205                 210                 215

 ctg gac gtc acg gcc cac gcg ggc acg ctg ccc tca cgc atg acc gtc     1025
 Leu Asp Val Thr Ala His Ala Gly Thr Leu Pro Ser Arg Met Thr Val
             220                 225                 230

 ctg tac gtg gac acc atc ggc ttc ctc tcc cag ctg ccg cac ggc ctc     1073
 Leu Tyr Val Asp Thr Ile Gly Phe Leu Ser Gln Leu Pro His Gly Leu
         235                 240                 245

 atc gag tcc ttc tcc gcc acc ctg gaa gac gtg gcc cac tcg gat ctc     1121
 Ile Glu Ser Phe Ser Ala Thr Leu Glu Asp Val Ala His Ser Asp Leu
     250                 255                 260

 atc ttg cac gtg agg gac gtc agc cac ccc gag gcg gag ctc cag aaa     1169
 Ile Leu His Val Arg Asp Val Ser His Pro Glu Ala Glu Leu Gln Lys
 265                 270                 275                 280

 tgc agc gtt ctg tcc acg ctg cgt ggc ctg cag ctg ccc gcc ccg ctc     1217
 Cys Ser Val Leu Ser Thr Leu Arg Gly Leu Gln Leu Pro Ala Pro Leu
                 285                 290                 295

 ctg gac tcc atg gtg gag gtt cac aac aag gtg gac ctc gtg ccc ggg     1265
 Leu Asp Ser Met Val Glu Val His Asn Lys Val Asp Leu Val Pro Gly
             300                 305                 310

 tac agc ccc acg gaa ccg aac gtc gtg ccc gtg tct gcc ctg cgg ggc     1313
 Tyr Ser Pro Thr Glu Pro Asn Val Val Pro Val Ser Ala Leu Arg Gly
         315                 320                 325

 cac ggg ctc cag gag ctg aaa gct gag ctc gat gcg gcg gtt ttg aag     1361
 His Gly Leu Gln Glu Leu Lys Ala Glu Leu Asp Ala Ala Val Leu Lys
     330                 335                 340

 gcg acg ggg aga cag atc ctc act ctc cgt gtg agg ctc gca ggg gcg     1409
 Ala Thr Gly Arg Gln Ile Leu Thr Leu Arg Val Arg Leu Ala Gly Ala
 345                 350                 355                 360

 cag ctc agc tgg ctg tat aag gag gcc aca gtt cag gag gtg gac gtg     1457
 Gln Leu Ser Trp Leu Tyr Lys Glu Ala Thr Val Gln Glu Val Asp Val
                 365                 370                 375

 atc cct gag gac ggg gcg gcc gac gtg agg gtc atc atc agc aac tca     1505
 Ile Pro Glu Asp Gly Ala Ala Asp Val Arg Val Ile Ile Ser Asn Ser
             380                 385                 390

 gcc tac ggc aaa ttc cgg aag ctc ttt cca gga tga acgg acgcccacag     1555
 Ala Tyr Gly Lys Phe Arg Lys Leu Phe Pro Gly 
         395                 400

 aggcctgcgg ggtgggggca ttgctgcctg gggagctgag gcgttaccgc tgtgttgggg   1615

 gcagcttggt gtcaggtgca gcagggtcct ccttgtctgg ttctgcaccc gtctcgctcc   1675

 cagccatttg ctgggatgac cgtgcaggcc ggtgacacgg ccgcacctgc cccaaagcgg   1735

 gccgcccgag cgtccactcc aagcctgagc atccacacaa ttccagtggg ccctcggtgc   1795

 ctgctgtgaa ctgctttccc tcggaatgtt tccgtaacag gacattaaac ctttgatttt   1855

 acttcaaaaa aaaaaa                                                   1871




      <210> 155
      <211> 2046
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (167)..(343)

      <400> 155
 aagctggtac gcctgcaggt tttggtcctt aattcccggg tcgacgattt cgtcgggaag     60

 ccaccccgcc tctccgaggc ctccctgccc cgccccgtca cgcccctttc ccggcgggac    120

 gctttgagcc gccccgaact aagcagggcg gtcgggggag gtgcta   atg atg ctg     175
                                                      Met Met Leu
                                                        1

 gat aac tat gta aga gat ttc aaa gca ttg att gac tgg att cag ctt      223
 Asp Asn Tyr Val Arg Asp Phe Lys Ala Leu Ile Asp Trp Ile Gln Leu
       5                  10                  15

 cag gaa aag cta gag aag aca gat gct caa agc aga cca aca tca ttg      271
 Gln Glu Lys Leu Glu Lys Thr Asp Ala Gln Ser Arg Pro Thr Ser Leu
  20                  25                  30                  35

 gca tgg gaa gta aag aag atg tct ccg gga cgc cat gtg att cca agt      319
 Ala Trp Glu Val Lys Lys Met Ser Pro Gly Arg His Val Ile Pro Ser
                  40                  45                  50

 cca tca aca gat aga aaa atg taa catcaaatgc tcgacgaagc ttaaattttg     373
 Pro Ser Thr Asp Arg Lys Met 
              55

 gaggttcaac tggcacagtg ccagctcctc gtctggctcc cacaggtgtc agttgggctg    433

 acaaggtcca agtgcacagg ctagcagtca caggttccac atgcacgcag ttgcagctgg    493

 cagagtgtga acagtattcg cacactggtg atggcagggc aatggcaacg gagtccatac    553

 ctgcaccggt gccagtagca gcatggtggc aaagtccatg cagctgccag aaagtgcaca    613

 agaagagtga tgctagcaat ttggatatgc caaacagaag ttgtaaagtg cttcctttaa    673

 atgaaagcgt gaaagttctc aacttactaa ggaaaggaaa gaaatcttat gctgaggtta    733

 ctgaaatcag tgtgttggaa gttctggcca gggcagtcag acaggagaag gaaataaagg    793

 gcattcaatt aggaaaaggg gaagtcaaat tgtccctgtt tgccgatgac atgattgtat    853

 atctagaaaa ccccatcgtc tcagcccaaa atctccttaa gctgataagc aacttcagca    913

 aagtctcagg atacaaaatc agtgtacaaa aatcacaagc attcttatac accaataaca    973

 gacaaacaga gagccaaatc atgagtgaac tcccattcac aattgcttca aagagaataa   1033

 aatacctagg aatccacctt acaagggacg tgaaggacct cttcaaggag aactacaaac   1093

 cactgctcaa tgaaataaaa gaggacacaa acaaatggaa gaacattcca tgctcatggg   1153

 taggaagaat caatatcgtg aaaatggcca tactgcccaa ggtaatttat agattcaatg   1213

 ccatccccat caagctgcca atgactttct tcacagaatt ggaaaaaact actttaaagt   1273

 tcatatggaa ccaaaaaaga gcccgcatcg ccaagtcaat cctaagccaa aagaacaaag   1333

 ctggaggcat cacactacct gacttcaaac tatactacaa ggctacagta accaaaacag   1393

 catggtactg gtaccaaaac agagttatag accaatggaa cagaacagag ccctcagaaa   1453

 taatgccgca tatctacaac tacctgatct ttgacaaacc tgagaaaaag aagcaatggg   1513

 gaaaggattc cctatttaat aaaaggtgct gggcaaactg gctagccata tgtagaaagc   1573

 tgaaactgga tcccttcctt acaccttata caaaaattaa ttcaagatgg attaaagact   1633

 taaaggttag acctaaaacc ataaaaaccc tagaagaaaa cctaggcatt accattcagg   1693

 acataggcat gggcaaggac ttcatgtcta aaacaccaaa agcaatggca acaaaagcca   1753

 aaattgacaa atgggatcta attaaactaa agaccttctg cacagcaaaa gaaaccacca   1813

 tcagacatga tgaaagtatt cgaaggcaca tggaacagat tgaacaaaga aaagaaaaag   1873

 ctgctgagct aagcagtggg cgacatgcaa atactgatta tgcccccaaa ctgacccctt   1933

 atgaaagaaa gaagcagtgt tctctctgca atgtcctgac caacatcatt ggcatgggaa   1993

 gtaaagaaga tgtctccggg acgccatgtg attccaagtc catcaacaga tag          2046




      <210> 156
      <211> 1143
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (433)..(801)

      <400> 156
 aaatgtccct gtctgacagc tttgaagaga gtagtggttc tcccagcaca cagctggaga     60

 tctgagaatg gacagactgc ctcctcaagt gggtccctga cctccgagta gcctaactgg    120

 gaggcaccct ccagtagggg ccgactgaca cctcatgcgc ctgggtatcc ctctgagacg    180

 aagcttccag aggaacaatc aggcagcaac atttgctgtt cagcaatatt cactgttctg    240

 cagcccaggc aaacagggtc tggagtggac ctccagcaaa ctccagcaga cctgcagcag    300

 aggggcctga ctgttagaag gaaaactaac aaaaggaata gcatcaatat caacaaaaat    360

 gacgtccaca cagaaacccc agaaacccca tctgcaggtc accaacatca aacaccaaag    420

 gcagataaat cc    atg aag atg agg aaa aac cag cac aaa aag gct gaa     468
                  Met Lys Met Arg Lys Asn Gln His Lys Lys Ala Glu
                    1               5                  10

 aat ttc aaa aac cag aac gcc tct tct cct cta aag gat tac aac tgc      516
 Asn Phe Lys Asn Gln Asn Ala Ser Ser Pro Leu Lys Asp Tyr Asn Cys
          15                  20                  25

 tcg cca gca aag gag caa aac tgg aca gag aat gag ttt gac aaa ttg      564
 Ser Pro Ala Lys Glu Gln Asn Trp Thr Glu Asn Glu Phe Asp Lys Leu
      30                  35                  40

 aca gaa gta ggc ttc aga aga aca gac gtc tct ggc atg gcc tct agc      612
 Thr Glu Val Gly Phe Arg Arg Thr Asp Val Ser Gly Met Ala Ser Ser
  45                  50                  55                  60

 ctt cca tcc ctg gaa gag tgg cag ggc tgt tct gag cca atg gat gat      660
 Leu Pro Ser Leu Glu Glu Trp Gln Gly Cys Ser Glu Pro Met Asp Asp
                  65                  70                  75

 tcc tac ctg act ctc agg aaa gtg acc cat gga ggg tct gct cca cca      708
 Ser Tyr Leu Thr Leu Arg Lys Val Thr His Gly Gly Ser Ala Pro Pro
              80                  85                  90

 cca tca aca ctg cag tca gga cca ctc ttg aat aag gga tat tgc agg      756
 Pro Ser Thr Leu Gln Ser Gly Pro Leu Leu Asn Lys Gly Tyr Cys Arg
          95                 100                 105

 agt cta act gcc ctg agg cag gcc tta gaa acc cat agt cta tga ccc      804
 Ser Leu Thr Ala Leu Arg Gln Ala Leu Glu Thr His Ser Leu 
     110                 115                 120

 agcgacattg tgcccgtgac cctcttcgct gcagggtgag tagagccact tacttgaggc    864

 ttccaggcta agtgcaatga gaaagctcaa gaaagggata ttaagaagtt acgaatgata    924

 agttaggtaa aagagagtag gtggaggctg gggctctccc tacatgcact ggaagaagac    984

 attgttaata aagcatttaa agctctgttg aatgtcaata atacatatcc ttctgctatc   1044

 agttagtggg ggtgcgagtc tttgtaggta tgagaaaaaa aatgtccagg cttgtgcaca   1104

 tcaaccaaaa ttgtttcgga cgcgtgggtc gacccggga                          1143




      <210> 157
      <211> 1723
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (402)..(1334)

      <400> 157
 acaacccaat tcggcacgag gggcattgga aatagcagag tgcttcgcgg taacaggggt     60

 tggagtgcaa tggtgtgatc tcagctcact gcaacccctg cctcccaggc tccagcgatc    120

 ctcccacctc agcctcctga atagctgacc accagcacac taggcaaacc caccccactc    180

 accgcctccc ttgggaattc agacctaacc atcgctgagc tgaagtacaa atgtactgag    240

 gctggagcct gtgtgaacag aacagaagag gccttcactc tagtagtgct cacagtccag    300

 cagcaggtgt ttgctgaaga cagcttactc agatcactac tgcctggagg tggttgatat    360

 atcctggtgt aaaccttcaa gaagggcaca ggcaggaaaa c    atg agc cag caa     413
                                                  Met Ser Gln Gln
                                                    1

 ctg aag aaa cgg gca aag aca aga cac cag aaa ggc ctg ggt gga aga      461
 Leu Lys Lys Arg Ala Lys Thr Arg His Gln Lys Gly Leu Gly Gly Arg
   5                  10                  15                  20

 gcc ccc agt ggg gct aag ccc agg caa ggc aag tca agc caa gac ctg      509
 Ala Pro Ser Gly Ala Lys Pro Arg Gln Gly Lys Ser Ser Gln Asp Leu
                  25                  30                  35

 cag gcg gaa ata gaa cct gtc agc gcg gtg tgg gcc tta tgt gat ggc      557
 Gln Ala Glu Ile Glu Pro Val Ser Ala Val Trp Ala Leu Cys Asp Gly
              40                  45                  50

 tat gtg tgc tat gag cct ggc cct cag gct ctc gga ggg gat gat ttc      605
 Tyr Val Cys Tyr Glu Pro Gly Pro Gln Ala Leu Gly Gly Asp Asp Phe
          55                  60                  65

 tca gac tgt tac ata gaa tgc gtc ata agg ggt gag ttt tct caa ccc      653
 Ser Asp Cys Tyr Ile Glu Cys Val Ile Arg Gly Glu Phe Ser Gln Pro
      70                  75                  80

 atc ctg gaa gag gac tca ctt ttt gag tcc ttg gaa tac cta aag aaa      701
 Ile Leu Glu Glu Asp Ser Leu Phe Glu Ser Leu Glu Tyr Leu Lys Lys
  85                  90                  95                 100

 gga tca gaa caa cag ctt tct caa aag gtt ttc gaa gca agc tcc ctt      749
 Gly Ser Glu Gln Gln Leu Ser Gln Lys Val Phe Glu Ala Ser Ser Leu
                 105                 110                 115

 gaa tgt tct ttg gaa tac atg aaa aaa ggg gta aag aaa gag ctt cca      797
 Glu Cys Ser Leu Glu Tyr Met Lys Lys Gly Val Lys Lys Glu Leu Pro
             120                 125                 130

 caa aag ata gtt gga gag aat tcg ctt gag tat tct gag tac atg aca      845
 Gln Lys Ile Val Gly Glu Asn Ser Leu Glu Tyr Ser Glu Tyr Met Thr
         135                 140                 145

 ggc aag aag ctt ccg cct gga gga ata cct ggc att gac cta tca gat      893
 Gly Lys Lys Leu Pro Pro Gly Gly Ile Pro Gly Ile Asp Leu Ser Asp
     150                 155                 160

 cct aaa cag ctc gca gaa ttt gct aga aag aag ccc ccc ata aat aaa      941
 Pro Lys Gln Leu Ala Glu Phe Ala Arg Lys Lys Pro Pro Ile Asn Lys
 165                 170                 175                 180

 gaa tat gac agt ctg agc gca atc gct tgt cct cag agt gga tgc act      989
 Glu Tyr Asp Ser Leu Ser Ala Ile Ala Cys Pro Gln Ser Gly Cys Thr
                 185                 190                 195

 agg aag ttg agg aat aga gct gcc ctg aga aag cat ctc ctc att cat     1037
 Arg Lys Leu Arg Asn Arg Ala Ala Leu Arg Lys His Leu Leu Ile His
             200                 205                 210

 ggt ccc cga gac cac gtc tgt gcg gaa tgt ggg aaa gcg ttc gtt gag     1085
 Gly Pro Arg Asp His Val Cys Ala Glu Cys Gly Lys Ala Phe Val Glu
         215                 220                 225

 agc tca aaa cta aag aga cat ttc ctg gtt cat act gga gag aag ccg     1133
 Ser Ser Lys Leu Lys Arg His Phe Leu Val His Thr Gly Glu Lys Pro
     230                 235                 240

 ttt cgg tgc act ttt gaa ggg tgc gga aag cgc ttc tct ctg gac ttt     1181
 Phe Arg Cys Thr Phe Glu Gly Cys Gly Lys Arg Phe Ser Leu Asp Phe
 245                 250                 255                 260

 aat ttg cgt acg cac gtg cgc atc cac acg ggg gag aaa cgt ttc gtg     1229
 Asn Leu Arg Thr His Val Arg Ile His Thr Gly Glu Lys Arg Phe Val
                 265                 270                 275

 tgt ccc ttt caa ggc tgc aac agg agg ttt att cag tca aat aac ctg     1277
 Cys Pro Phe Gln Gly Cys Asn Arg Arg Phe Ile Gln Ser Asn Asn Leu
             280                 285                 290

 aaa gcc cac atc cta acg cat gca aat acg aac aag aat gaa caa gag     1325
 Lys Ala His Ile Leu Thr His Ala Asn Thr Asn Lys Asn Glu Gln Glu
         295                 300                 305

 gga aag tag tcctcca acaggatgaa gcagattaac agaagagtga tcagtgacaa     1381
 Gly Lys 
     310

 acatgcctca ttgattattg tttctaggaa ggaattttta aatcaatatt gcaaccccaa   1441

 aagcggttat aatttggtgt tactaagatg ctcctacact ttgtgatacc gttttaagga   1501

 catggtgcat ttttttttct tttatttgtt ttatttagaa ctttttttat ttgttttatt   1561

 tagaactttg tgtgttctta aagtgtgctt ccaacaggaa ggtcagtgat aaattttcaa   1621

 aagcataacc ttcaatatat tatctgttgg attattggat ataagactta ttttcatgta   1681

 ctataaatat gaaaataact ttgattttta aaaaaaaaaa aa                      1723




      <210> 158
      <211> 2462
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2310)

      <400> 158
  atg tct tcg cgg acg gtg ctg gcc ccg ggc aac gat cgg aac tcg gac      48
  Met Ser Ser Arg Thr Val Leu Ala Pro Gly Asn Asp Arg Asn Ser Asp
    1               5                  10                  15

 acg cat ggc acc ttg ggc agt ggc cgc tcc tcg gac aaa ggc ccg tcc       96
 Thr His Gly Thr Leu Gly Ser Gly Arg Ser Ser Asp Lys Gly Pro Ser
              20                  25                  30

 tgg tcc agc cgc tca ctg ggt gcc cgt tgc cgg aac tcc atc gcc tcc      144
 Trp Ser Ser Arg Ser Leu Gly Ala Arg Cys Arg Asn Ser Ile Ala Ser
          35                  40                  45

 tgt ccc gag gag cag ccc cac gtg ggc aac tac cgc ctg ctg agg acc      192
 Cys Pro Glu Glu Gln Pro His Val Gly Asn Tyr Arg Leu Leu Arg Thr
      50                  55                  60

 att ggg aag ggc aac ttt gcc aaa gtc aag ctg gct cgg cac atc ctc      240
 Ile Gly Lys Gly Asn Phe Ala Lys Val Lys Leu Ala Arg His Ile Leu
  65                  70                  75                  80

 act ggt cgg gag gtt gcc atc aag att atc gac aaa acc cag ctg aat      288
 Thr Gly Arg Glu Val Ala Ile Lys Ile Ile Asp Lys Thr Gln Leu Asn
                  85                  90                  95

 ccc agc agc ctg cag aag ctg ttc cga gaa gtc cgc atc atg aag ggc      336
 Pro Ser Ser Leu Gln Lys Leu Phe Arg Glu Val Arg Ile Met Lys Gly
             100                 105                 110

 cta aac cac ccc aac atc gtg aag ctc ttt gag gtg att gag act gag      384
 Leu Asn His Pro Asn Ile Val Lys Leu Phe Glu Val Ile Glu Thr Glu
         115                 120                 125

 aag acg ctg tac ctg gtg atg gag tac gca agt gct gga gaa gtg ttt      432
 Lys Thr Leu Tyr Leu Val Met Glu Tyr Ala Ser Ala Gly Glu Val Phe
     130                 135                 140

 gac tac ctc gtg tcg cat ggc cgc atg aag gag aag gaa gct cga gcc      480
 Asp Tyr Leu Val Ser His Gly Arg Met Lys Glu Lys Glu Ala Arg Ala
 145                 150                 155                 160

 aag ttc cga cag att gtt tcg gct gtg cac tat tgt cac cag aaa aat      528
 Lys Phe Arg Gln Ile Val Ser Ala Val His Tyr Cys His Gln Lys Asn
                 165                 170                 175

 att gta cac agg gac ctg aag gct gag aac ctc ttg ctg gat gcc gag      576
 Ile Val His Arg Asp Leu Lys Ala Glu Asn Leu Leu Leu Asp Ala Glu
             180                 185                 190

 gcc aac atc aag att gct gac ttt ggc ttc agc aac gag ttc acg ctg      624
 Ala Asn Ile Lys Ile Ala Asp Phe Gly Phe Ser Asn Glu Phe Thr Leu
         195                 200                 205

 gga tcg aag ctg gac acg ttc tgc ggg agc ccc cca tat gcc gcc ccg      672
 Gly Ser Lys Leu Asp Thr Phe Cys Gly Ser Pro Pro Tyr Ala Ala Pro
     210                 215                 220

 gag ctg ttt cag ggc aag aag tac gac ggg ccg gag gtg gac atc tgg      720
 Glu Leu Phe Gln Gly Lys Lys Tyr Asp Gly Pro Glu Val Asp Ile Trp
 225                 230                 235                 240

 agc ctg gga gtc atc ctg tac acc ctc gtc agc ggc tcc ctg ccc ttc      768
 Ser Leu Gly Val Ile Leu Tyr Thr Leu Val Ser Gly Ser Leu Pro Phe
                 245                 250                 255

 gac ggg cac aac ctc aag gag ctg cgg gag cga gta ctc aga ggg aag      816
 Asp Gly His Asn Leu Lys Glu Leu Arg Glu Arg Val Leu Arg Gly Lys
             260                 265                 270

 tac cgg gtc cct ttc tac atg tca aca gac tgt gag agc atc ctg cgg      864
 Tyr Arg Val Pro Phe Tyr Met Ser Thr Asp Cys Glu Ser Ile Leu Arg
         275                 280                 285

 aga ttt ttg gtg ctg aac cca gct aaa cgc tgt act ctc gag caa atc      912
 Arg Phe Leu Val Leu Asn Pro Ala Lys Arg Cys Thr Leu Glu Gln Ile
     290                 295                 300

 atg aaa gac aaa tgg atc aac atc ggc tat gag ggt gag gag ttg aag      960
 Met Lys Asp Lys Trp Ile Asn Ile Gly Tyr Glu Gly Glu Glu Leu Lys
 305                 310                 315                 320

 cca tac aca gag ccc gag gag gac ttc ggg gac acc aag aga att gag     1008
 Pro Tyr Thr Glu Pro Glu Glu Asp Phe Gly Asp Thr Lys Arg Ile Glu
                 325                 330                 335

 gtg atg gtg ggt atg ggc tac aca cgg gaa gaa atc aaa gag tcc ttg     1056
 Val Met Val Gly Met Gly Tyr Thr Arg Glu Glu Ile Lys Glu Ser Leu
             340                 345                 350

 acc agc cag aag tac aac gaa gtg acc gcc acc tac ctc ctg ctg ggc     1104
 Thr Ser Gln Lys Tyr Asn Glu Val Thr Ala Thr Tyr Leu Leu Leu Gly
         355                 360                 365

 agg aag act gag gag ggt ggg gac cgg ggc gcc cca ggg ctg gcc ctg     1152
 Arg Lys Thr Glu Glu Gly Gly Asp Arg Gly Ala Pro Gly Leu Ala Leu
     370                 375                 380

 gca cgg gtg cgg gcg ccc agc gac acc acc aac gga aca agt tcc agc     1200
 Ala Arg Val Arg Ala Pro Ser Asp Thr Thr Asn Gly Thr Ser Ser Ser
 385                 390                 395                 400

 aaa ggc acc agc cac agc aaa ggg cag cgg agt tcc tct tcc acc tac     1248
 Lys Gly Thr Ser His Ser Lys Gly Gln Arg Ser Ser Ser Ser Thr Tyr
                 405                 410                 415

 cac cgc cag cgc agg cat agc gat ttc tct act aat cta ctt tct atg     1296
 His Arg Gln Arg Arg His Ser Asp Phe Ser Thr Asn Leu Leu Ser Met
             420                 425                 430

 tcg atg aat ttg gct att cta gac att tca ggt ggc cca tcc cct gca     1344
 Ser Met Asn Leu Ala Ile Leu Asp Ile Ser Gly Gly Pro Ser Pro Ala
         435                 440                 445

 ccc ctg cac ccc aaa cgc agc ccg acg agc acg ggg gag gcg gag ctg     1392
 Pro Leu His Pro Lys Arg Ser Pro Thr Ser Thr Gly Glu Ala Glu Leu
     450                 455                 460

 aag gag gag cgg ctg cca ggc cgg aag gcg agc tgc agc acc gcg ggg     1440
 Lys Glu Glu Arg Leu Pro Gly Arg Lys Ala Ser Cys Ser Thr Ala Gly
 465                 470                 475                 480

 agt ggg agt cga ggg ctg ccc ccc tcc agc ccc atg gtc agc agc gcc     1488
 Ser Gly Ser Arg Gly Leu Pro Pro Ser Ser Pro Met Val Ser Ser Ala
                 485                 490                 495

 cac aac ccc aac aag gca gag atc cca gag cgg cgg aag gac agc acg     1536
 His Asn Pro Asn Lys Ala Glu Ile Pro Glu Arg Arg Lys Asp Ser Thr
             500                 505                 510

 agc acc ccc aac aac ctc cct cct agc atg atg acc cgc aga aac acc     1584
 Ser Thr Pro Asn Asn Leu Pro Pro Ser Met Met Thr Arg Arg Asn Thr
         515                 520                 525

 tac gtt tgc aca gaa cgc ccg ggg gct gag cgc ccg tca ctg ttg cca     1632
 Tyr Val Cys Thr Glu Arg Pro Gly Ala Glu Arg Pro Ser Leu Leu Pro
     530                 535                 540

 aat ggg aaa gaa aac agc tca ggc acc cca cgg gtg ccc cct gcc tcc     1680
 Asn Gly Lys Glu Asn Ser Ser Gly Thr Pro Arg Val Pro Pro Ala Ser
 545                 550                 555                 560

 ccc tcc agt cac agc ctg gca ccc cca tca ggg gag cgg agc cgc ctg     1728
 Pro Ser Ser His Ser Leu Ala Pro Pro Ser Gly Glu Arg Ser Arg Leu
                 565                 570                 575

 gca cgc ggt tcc acc atc cgc agc acc ttc cat ggt ggc cag gtc cgg     1776
 Ala Arg Gly Ser Thr Ile Arg Ser Thr Phe His Gly Gly Gln Val Arg
             580                 585                 590

 gac cgg cgg gca ggg ggt ggg ggt ggt ggg ggt gtg cag aat ggg ccc     1824
 Asp Arg Arg Ala Gly Gly Gly Gly Gly Gly Gly Val Gln Asn Gly Pro
         595                 600                 605

 cct gcc tct ccc aca ctg gcc cat gag gct gca ccc ctg ccc gcc ggg     1872
 Pro Ala Ser Pro Thr Leu Ala His Glu Ala Ala Pro Leu Pro Ala Gly
     610                 615                 620

 cgg ccc cgc ccc acc acc aac ctc ttc acc aag ctg acc tcc aaa ctg     1920
 Arg Pro Arg Pro Thr Thr Asn Leu Phe Thr Lys Leu Thr Ser Lys Leu
 625                 630                 635                 640

 acc cga agg gtc gca gac gaa cct gag aga atc ggg gga cct gag gtc     1968
 Thr Arg Arg Val Ala Asp Glu Pro Glu Arg Ile Gly Gly Pro Glu Val
                 645                 650                 655

 aca agt tgc cat cta cct tgg gat caa acg gaa acc gcc ccc cgg ctg     2016
 Thr Ser Cys His Leu Pro Trp Asp Gln Thr Glu Thr Ala Pro Arg Leu
             660                 665                 670

 ctc cga ttc ccc tgg agt gtg aag ctg acc agc tcg cgc cct cct gag     2064
 Leu Arg Phe Pro Trp Ser Val Lys Leu Thr Ser Ser Arg Pro Pro Glu
         675                 680                 685

 gcc ctg atg gca gct ctg cgc cag gcc aca gca gcc gcc cgc tgc cgc     2112
 Ala Leu Met Ala Ala Leu Arg Gln Ala Thr Ala Ala Ala Arg Cys Arg
     690                 695                 700

 tgc cgc cag cca cag ccg ttc ctg ctg gcc tgc ctg cac ggg ggt gcg     2160
 Cys Arg Gln Pro Gln Pro Phe Leu Leu Ala Cys Leu His Gly Gly Ala
 705                 710                 715                 720

 ggc ggg ccc gag ccc ctg tcc cac ttc gaa gtg gag gtc tgc cag ctg     2208
 Gly Gly Pro Glu Pro Leu Ser His Phe Glu Val Glu Val Cys Gln Leu
                 725                 730                 735

 ccc cgg cca ggc ttg cgg gga gtt ctc ttc cgc cgt gtg gcg ggc acc     2256
 Pro Arg Pro Gly Leu Arg Gly Val Leu Phe Arg Arg Val Ala Gly Thr
             740                 745                 750

 gcc ctg gcc ttc cgc acc ctc gtc acc cgc atc tcc aac gac ctc gag     2304
 Ala Leu Ala Phe Arg Thr Leu Val Thr Arg Ile Ser Asn Asp Leu Glu
         755                 760                 765

 ctc tga gccaccacgg tcccagggcc cttactcttc ctctcccttg tcgccttcac      2360
 Leu 


 ttctacagga ggggaagggg ccagggaggg gattctccct ttatcatcac ctcagtttcc   2420

 ctgaattata tttgggggca aagattgaaa aaaaaaaaaa aa                      2462




      <210> 159
      <211> 799
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (257)..(733)

      <400> 159
 gcgctgcagg aattcggcac gaggtggggc ctaagactct cgcgagacac cgtctagcac     60

 ttcccgcccg tcagtccttc acagtgcccg aatcgcccgc tggtttaagt gcagcctgtc    120

 aatcagagca gctctcgagg ccccgcccaa ggccgtgctg cgtttctcct tacgtcactt    180

 cctctccagc ccctgcgtaa tcgataagga aacccggacg ctgctgcccc tttttttttt    240

 tcaggcggcc gggaag    atg gcg gac att cag act gag cgt gcc tac caa     289
                      Met Ala Asp Ile Gln Thr Glu Arg Ala Tyr Gln
                        1               5                  10

 aag cag ccg acc atc ttt caa aac aag aag agg gtc ctg ctg gga gaa      337
 Lys Gln Pro Thr Ile Phe Gln Asn Lys Lys Arg Val Leu Leu Gly Glu
              15                  20                  25

 act ggc aag gag aag ctc ccg cgg tac tac aag aac atc ggt ctg ggc      385
 Thr Gly Lys Glu Lys Leu Pro Arg Tyr Tyr Lys Asn Ile Gly Leu Gly
          30                  35                  40

 ttc aag aca ccc aag gag gct att gag ggc acc tac att gac aag aaa      433
 Phe Lys Thr Pro Lys Glu Ala Ile Glu Gly Thr Tyr Ile Asp Lys Lys
      45                  50                  55

 tgc ccc ttc act ggt aat gtg tcc att cga ggg cgg atc ctc tct ggc      481
 Cys Pro Phe Thr Gly Asn Val Ser Ile Arg Gly Arg Ile Leu Ser Gly
  60                  65                  70                  75

 gtg gtg acc aag atg aag atg cag agg acc att gtc atc cgc cga gac      529
 Val Val Thr Lys Met Lys Met Gln Arg Thr Ile Val Ile Arg Arg Asp
                  80                  85                  90

 tat ctg cac tac atc cgc aag tac aac cgc ttc gag aag cgc cac aag      577
 Tyr Leu His Tyr Ile Arg Lys Tyr Asn Arg Phe Glu Lys Arg His Lys
              95                 100                 105

 aac atg tct gta cac ctg tcc ccc tgc ttc agg gac gtc cag atc ggt      625
 Asn Met Ser Val His Leu Ser Pro Cys Phe Arg Asp Val Gln Ile Gly
         110                 115                 120

 gac atc gtc aca gtg ggc gag tgc cgg cct ctg agc aag aca gtg cgc      673
 Asp Ile Val Thr Val Gly Glu Cys Arg Pro Leu Ser Lys Thr Val Arg
     125                 130                 135

 ttc aac gtg ctc aag gtc acc aag gct gcc ggc acc aag aag cag ttc      721
 Phe Asn Val Leu Lys Val Thr Lys Ala Ala Gly Thr Lys Lys Gln Phe
 140                 145                 150                 155

 cag aag ttc tga ggc tggacatcgg cccgctcccc acaatgaaat aaagttattt      776
 Gln Lys Phe 


 tctcattccc aaaaaaaaaa aaa                                            799




      <210> 160
      <211> 1630
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (638)..(826)

      <400> 160
 gtttcaagaa gtttagaatt tcacatactt catgctagag agggaaacag aattctagtt     60

 gctagaaaag atcaaggttg ctatttgttc ctttgaagtt aactgtctac ccatctccga    120

 gggctgcatg gggctttttg ttaagatgta tttccagtca ccccaagcca gaacccatca    180

 acagcatcca gttggacaac ctgtgtatgt ttcaggcaga gtgtttctga gttgagaatg    240

 ttttctcctt aagttggaat agaaagcatt agtgctgaaa taaccttcaa taaatcaccg    300

 ttgtattatt gcatataagc gatgtgttta aatttagcag gctgctttct cctgatgaaa    360

 accatttgtg acaacatgtc agttgtttct ttggtgattt gtgtcacagg ctttctttac    420

 agatgcggtg taaatgaaat ttttaacggg gttcaaaatc agatggctaa atgtgttaat    480

 attctcattt aaacccaact acctttcttc gtctccaagc ccctataatt taactctgaa    540

 ctataatctt ttccattcta tctagctccc atcctaagtc ctctcctcct aacgtggaac    600

 tctcctaaaa tcttctcctt atactagggt tcgagac atg agg ctg tct ttt tgg     655
                                          Met Arg Leu Ser Phe Trp
                                            1               5

 gcc ttt tgc gtt gtc aca gtc cca gac cac gga aca ttc tct ctt ccc      703
 Ala Phe Cys Val Val Thr Val Pro Asp His Gly Thr Phe Ser Leu Pro
              10                  15                  20

 cag gac agg aca ttc tct ctt ccc cag cct cct tcc tgt cct ggc gtt      751
 Gln Asp Arg Thr Phe Ser Leu Pro Gln Pro Pro Ser Cys Pro Gly Val
          25                  30                  35

 gag tct tcc aaa tgg aaa att cca gcc ata tca att ggt gat gca ccc      799
 Glu Ser Ser Lys Trp Lys Ile Pro Ala Ile Ser Ile Gly Asp Ala Pro
      40                  45                  50

 att tct tcc tgt gga acg aca gtc tga tggaa ttgcttctgg agtaaatgcc      851
 Ile Ser Ser Cys Gly Thr Thr Val 
  55                  60

 cagcttctta ccacttcagt gtcagcctga atgtttggaa agttctagca cctcaaacca    911

 tttgcatcta tgaaagcaga actctatttt ttccctttgg tttagcttgt gagttctctg    971

 tgggaggaag atctgatatg gccggctctc tttcaaccct agttccagca gagagagaga   1031

 gagaatgttc tgggtgacgg accctcccag caaaggggct tgctttattt gcttctctcc   1091

 ccaaccctcc actcttagcc tttgtctttt gaataatcct tcctcattcc acttttgtgg   1151

 tgggggataa ttagtcacaa ctcagtagta agccgtgcct gctgtagaga ggaagcattc   1211

 agggggttgg aagtgtggag accccagtct gattgctgga atcagtgctc ctcggttcag   1271

 tgttttgaga ccaggtcttt agcttctagc tgggcatatt tttctgcttt gtaatttaac   1331

 ctgtatcttt tttttcccat gttcctgcct catcagggaa ttgtaagatt tagggggagg   1391

 tgtgggaaat cttactcttt gccctaaagt attcagcgat cagaattctg gataccctgc   1451

 aaaacacctc caacctccct gcctttgaac cctgtgttaa caatgagaag cttgtttatt   1511

 tgaaggctgg gttctcattg gcccacaggg gtaggttgta attgtgtgtc taaaaaattg   1571

 ccttttgcat tccccaatag catgacaact ggaatagtaa tttgacttaa aaaaaaaaa    1630




      <210> 161
      <211> 425
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (97)..(396)

      <400> 161
 agggggcacg gaggtttgcg cgccttggtg agccgttggc gtggtggtcc cggagtgatc     60

 ctggcagccg ggggggaaga caaggagggt ttgagc  atg gca gaa gga aac acc     114
                                          Met Ala Glu Gly Asn Thr
                                            1               5

 ctg ata tca gtg gat tat gaa att ttt ggg aag gtg caa ggg gtg ttt      162
 Leu Ile Ser Val Asp Tyr Glu Ile Phe Gly Lys Val Gln Gly Val Phe
              10                  15                  20

 ttc cgt aag cat act cag gct gag ggt aaa aag ctg gga ttg gta ggc      210
 Phe Arg Lys His Thr Gln Ala Glu Gly Lys Lys Leu Gly Leu Val Gly
          25                  30                  35

 tgg gtc cag aac act gac cgg ggc aca gtg caa gga caa ttg caa ggt      258
 Trp Val Gln Asn Thr Asp Arg Gly Thr Val Gln Gly Gln Leu Gln Gly
      40                  45                  50

 ccc atc tcc aag gtg cgt cat atg cag gaa tgg ctt gaa aca aga gga      306
 Pro Ile Ser Lys Val Arg His Met Gln Glu Trp Leu Glu Thr Arg Gly
  55                  60                  65                  70

 agt cct aaa tca cac atc gac aaa gca aac ttc aac aat gaa aaa gtc      354
 Ser Pro Lys Ser His Ile Asp Lys Ala Asn Phe Asn Asn Glu Lys Val
                  75                  80                  85

 atc ttg aag ttg gat tac tca gac ttc caa att gta aaa taa tggcctg      403
 Ile Leu Lys Leu Asp Tyr Ser Asp Phe Gln Ile Val Lys 
              90                  95

 aatttaagtt ttctaagata ag                                             425




      <210> 162
      <211> 3519
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (56)..(2926)

      <400> 162
 tttcgtggag actagcttcc gcttccggtg tgagcggccc ggccgggggg gcaag atg      58
                                                              Met
                                                                1

 gcg gcg gca gta ggg gtt cgt ggc cgg tac gag ctg ccg cct tgc tcc      106
 Ala Ala Ala Val Gly Val Arg Gly Arg Tyr Glu Leu Pro Pro Cys Ser
               5                  10                  15

 ggc cca ggc tgg ctc ctc agc ctt tcc gcc ttg ctg agt gtg gcg gca      154
 Gly Pro Gly Trp Leu Leu Ser Leu Ser Ala Leu Leu Ser Val Ala Ala
          20                  25                  30

 cga ggg gcc ttc gcc acc acg cac tgg gtc gtc acg gag gac ggg aaa      202
 Arg Gly Ala Phe Ala Thr Thr His Trp Val Val Thr Glu Asp Gly Lys
      35                  40                  45

 atc cag cag cag gtg gat tca cca atg aac ttg aag cat cct cat gac      250
 Ile Gln Gln Gln Val Asp Ser Pro Met Asn Leu Lys His Pro His Asp
  50                  55                  60                  65

 cta gtc ata tta atg aga caa gaa gca aca gtt aac tac ctc aaa gaa      298
 Leu Val Ile Leu Met Arg Gln Glu Ala Thr Val Asn Tyr Leu Lys Glu
                  70                  75                  80

 tta gag aaa caa tta gtt gct caa aaa att cac ata gaa gag aat gag      346
 Leu Glu Lys Gln Leu Val Ala Gln Lys Ile His Ile Glu Glu Asn Glu
              85                  90                  95

 gac aga gac aca gga ctg gaa cag aga cat aat aaa gaa gac cca gac      394
 Asp Arg Asp Thr Gly Leu Glu Gln Arg His Asn Lys Glu Asp Pro Asp
         100                 105                 110

 tgc atc aaa gcc aag gtg ccc tta ggg gac ctg gat cta tat gat ggc      442
 Cys Ile Lys Ala Lys Val Pro Leu Gly Asp Leu Asp Leu Tyr Asp Gly
     115                 120                 125

 aca tac ata act ttg gag agc aaa gac atc agt cct gaa gat tat ata      490
 Thr Tyr Ile Thr Leu Glu Ser Lys Asp Ile Ser Pro Glu Asp Tyr Ile
 130                 135                 140                 145

 gac aca gaa tct cct gtc cct cca gac cca gag caa cct gat tgt act      538
 Asp Thr Glu Ser Pro Val Pro Pro Asp Pro Glu Gln Pro Asp Cys Thr
                 150                 155                 160

 aaa att cta gaa ctt cca tat agt ata cat gct ttt cag cac ttg aga      586
 Lys Ile Leu Glu Leu Pro Tyr Ser Ile His Ala Phe Gln His Leu Arg
             165                 170                 175

 ggt gta cag gag aga gtt aat ctt tct gca cct ctg cta cct aaa gaa      634
 Gly Val Gln Glu Arg Val Asn Leu Ser Ala Pro Leu Leu Pro Lys Glu
         180                 185                 190

 gac cca atc ttc aca tat tta tct aaa cgg tta gga agg agt ata gat      682
 Asp Pro Ile Phe Thr Tyr Leu Ser Lys Arg Leu Gly Arg Ser Ile Asp
     195                 200                 205

 gac ata ggt cac ctc att cat gaa ggc cta cag aag aac act tcc tcg      730
 Asp Ile Gly His Leu Ile His Glu Gly Leu Gln Lys Asn Thr Ser Ser
 210                 215                 220                 225

 tgg gta ctg tat aac atg gct tca ttt tac tgg aga att aag aat gag      778
 Trp Val Leu Tyr Asn Met Ala Ser Phe Tyr Trp Arg Ile Lys Asn Glu
                 230                 235                 240

 cca tat cag gta gta gaa tgt gcc atg cga gca ctt cac ttc tct tcc      826
 Pro Tyr Gln Val Val Glu Cys Ala Met Arg Ala Leu His Phe Ser Ser
             245                 250                 255

 agg cac aat aaa gac att gcc ctg gtc aac ctg gca aac gtt cta cac      874
 Arg His Asn Lys Asp Ile Ala Leu Val Asn Leu Ala Asn Val Leu His
         260                 265                 270

 aga gca cac ttc tct gct gat gct gct gtc gtg gtc cat gca gct ctg      922
 Arg Ala His Phe Ser Ala Asp Ala Ala Val Val Val His Ala Ala Leu
     275                 280                 285

 gat gac agt gac ttc ttc acc agc tat tac act ttg ggg aat ata tat      970
 Asp Asp Ser Asp Phe Phe Thr Ser Tyr Tyr Thr Leu Gly Asn Ile Tyr
 290                 295                 300                 305

 gca atg ctt ggg gaa tat aac cac tca gtg ctc tgt tat gac cac gct     1018
 Ala Met Leu Gly Glu Tyr Asn His Ser Val Leu Cys Tyr Asp His Ala
                 310                 315                 320

 ttg cag gcc aga cct ggg ttt ggg caa gct ata aag agg aag cat gct     1066
 Leu Gln Ala Arg Pro Gly Phe Gly Gln Ala Ile Lys Arg Lys His Ala
             325                 330                 335

 gtc cta tgt cag caa aaa ctg gag cag aaa ttg gag gct cag cat aga     1114
 Val Leu Cys Gln Gln Lys Leu Glu Gln Lys Leu Glu Ala Gln His Arg
         340                 345                 350

 tct ctc cag cga aca ctg aat gag tta aaa gag tat caa aag cag cat     1162
 Ser Leu Gln Arg Thr Leu Asn Glu Leu Lys Glu Tyr Gln Lys Gln His
     355                 360                 365

 gac cac tac ctg aga cag cag gaa atc cta gaa aaa cat aaa ctg att     1210
 Asp His Tyr Leu Arg Gln Gln Glu Ile Leu Glu Lys His Lys Leu Ile
 370                 375                 380                 385

 cag gag gag caa atc tta aga aat atc att cat gag act cag atg gca     1258
 Gln Glu Glu Gln Ile Leu Arg Asn Ile Ile His Glu Thr Gln Met Ala
                 390                 395                 400

 aaa gag gca caa tta gga aat cat cag ata tgc cga ctg gtc aac cag     1306
 Lys Glu Ala Gln Leu Gly Asn His Gln Ile Cys Arg Leu Val Asn Gln
             405                 410                 415

 cag cat agt tta cat tgc cag tgg gac cag cct gta cgc tat cat cgt     1354
 Gln His Ser Leu His Cys Gln Trp Asp Gln Pro Val Arg Tyr His Arg
         420                 425                 430

 gga gat atc ttt gaa aat gtg gac tat gtt cag ttt ggt gag gat tca     1402
 Gly Asp Ile Phe Glu Asn Val Asp Tyr Val Gln Phe Gly Glu Asp Ser
     435                 440                 445

 tca acc tcc agt atg atg tct gtg aac ttt gat gtt caa tca aat cag     1450
 Ser Thr Ser Ser Met Met Ser Val Asn Phe Asp Val Gln Ser Asn Gln
 450                 455                 460                 465

 agt gat atc aat gat tcg gtc aag tct tct ccc gta gcc cat tct att     1498
 Ser Asp Ile Asn Asp Ser Val Lys Ser Ser Pro Val Ala His Ser Ile
                 470                 475                 480

 ctc tgg att tgg ggc agg gac tct gat gca tat agg gac aaa cag cat     1546
 Leu Trp Ile Trp Gly Arg Asp Ser Asp Ala Tyr Arg Asp Lys Gln His
             485                 490                 495

 att cta tgg cct aaa aga gca gat tgt aca gaa agc tac cct aga gtc     1594
 Ile Leu Trp Pro Lys Arg Ala Asp Cys Thr Glu Ser Tyr Pro Arg Val
         500                 505                 510

 cct gtt ggt ggg gaa ttg cca acg tat ttt ctg cct ccg gaa aac aaa     1642
 Pro Val Gly Gly Glu Leu Pro Thr Tyr Phe Leu Pro Pro Glu Asn Lys
     515                 520                 525

 gga ctc agg atc cac gaa ctc agc agt gat gat tat tct aca gaa gaa     1690
 Gly Leu Arg Ile His Glu Leu Ser Ser Asp Asp Tyr Ser Thr Glu Glu
 530                 535                 540                 545

 gag gcc caa acc cct gac tgt tcc ata act gac ttc aga aaa agc cac     1738
 Glu Ala Gln Thr Pro Asp Cys Ser Ile Thr Asp Phe Arg Lys Ser His
                 550                 555                 560

 act ctg tcc tac tta gtc aaa gaa tta gag gtt cgc atg gat ctg aaa     1786
 Thr Leu Ser Tyr Leu Val Lys Glu Leu Glu Val Arg Met Asp Leu Lys
             565                 570                 575

 gcc aaa atg cca gat gac cat gca cga aaa att ttg ctt tcc cgt att     1834
 Ala Lys Met Pro Asp Asp His Ala Arg Lys Ile Leu Leu Ser Arg Ile
         580                 585                 590

 aat aac tat act atc cca gaa gaa gaa att ggg tct ttc tta ttt cat     1882
 Asn Asn Tyr Thr Ile Pro Glu Glu Glu Ile Gly Ser Phe Leu Phe His
     595                 600                 605

 gct att aat aag cca aat gct cct atc tgg ctc ata ctc aat gaa gct     1930
 Ala Ile Asn Lys Pro Asn Ala Pro Ile Trp Leu Ile Leu Asn Glu Ala
 610                 615                 620                 625

 gga cta tac tgg aga gca gta gga aat agc act ttt gct att gcc tgt     1978
 Gly Leu Tyr Trp Arg Ala Val Gly Asn Ser Thr Phe Ala Ile Ala Cys
                 630                 635                 640

 ctt cag agg gct ttg aat tta gct cca ctt caa tac caa gat gtt cct     2026
 Leu Gln Arg Ala Leu Asn Leu Ala Pro Leu Gln Tyr Gln Asp Val Pro
             645                 650                 655

 ctt gtc aac ttg gcc aac ctt ttg att cat tac ggc ctt cat ctt gat     2074
 Leu Val Asn Leu Ala Asn Leu Leu Ile His Tyr Gly Leu His Leu Asp
         660                 665                 670

 gcc act aag ctg cta ctt caa gct ttg gcc atc aat agc tct gag cct     2122
 Ala Thr Lys Leu Leu Leu Gln Ala Leu Ala Ile Asn Ser Ser Glu Pro
     675                 680                 685

 ctg acc ttt ttg agc ctg gga aat gct tac ctt gct ctg aag aat atc     2170
 Leu Thr Phe Leu Ser Leu Gly Asn Ala Tyr Leu Ala Leu Lys Asn Ile
 690                 695                 700                 705

 agt ggg gca ctt gag gcc ttt aga cag gcc ttg aaa tta acc acc aaa     2218
 Ser Gly Ala Leu Glu Ala Phe Arg Gln Ala Leu Lys Leu Thr Thr Lys
                 710                 715                 720

 tgt cca gag tgt gaa aac agc ctg aag ttg atc cgc tgt atg cag ttt     2266
 Cys Pro Glu Cys Glu Asn Ser Leu Lys Leu Ile Arg Cys Met Gln Phe
             725                 730                 735

 tat cct ttt ctg tac aac atc act tct tct gtt tgc agt ggt aat tgt     2314
 Tyr Pro Phe Leu Tyr Asn Ile Thr Ser Ser Val Cys Ser Gly Asn Cys
         740                 745                 750

 cat gag aaa acc ctg gac aac agc cat gac aaa cag aaa tat ttt gac     2362
 His Glu Lys Thr Leu Asp Asn Ser His Asp Lys Gln Lys Tyr Phe Asp
     755                 760                 765

 aac tca cag tca ctg gat gct gct gaa gaa gag ccc tct gag aga gga     2410
 Asn Ser Gln Ser Leu Asp Ala Ala Glu Glu Glu Pro Ser Glu Arg Gly
 770                 775                 780                 785

 aca gag gag gac cct gta ttc tct gtt gag aat tca ggg agg gac tca     2458
 Thr Glu Glu Asp Pro Val Phe Ser Val Glu Asn Ser Gly Arg Asp Ser
                 790                 795                 800

 gat gcc ctt aga ctt gaa agt acg gtg gtt gag gag agc aat ggt tct     2506
 Asp Ala Leu Arg Leu Glu Ser Thr Val Val Glu Glu Ser Asn Gly Ser
             805                 810                 815

 gat gag atg gag aat tca gat gaa acc aaa atg tca gaa gaa ata ctg     2554
 Asp Glu Met Glu Asn Ser Asp Glu Thr Lys Met Ser Glu Glu Ile Leu
         820                 825                 830

 gct ttg gtg gat gaa ttt caa cag gca tgg cct ttg gaa ggc ttt ggg     2602
 Ala Leu Val Asp Glu Phe Gln Gln Ala Trp Pro Leu Glu Gly Phe Gly
     835                 840                 845

 ggt gca cta gag atg aaa ggg cgg cgt cta gac tta caa gga ata cgg     2650
 Gly Ala Leu Glu Met Lys Gly Arg Arg Leu Asp Leu Gln Gly Ile Arg
 850                 855                 860                 865

 gtg ctg aag aaa ggt ccc cag gat gga gtg gcc aga agc tct tgc tat     2698
 Val Leu Lys Lys Gly Pro Gln Asp Gly Val Ala Arg Ser Ser Cys Tyr
                 870                 875                 880

 gga gac tgc aga agt gaa gat gat gaa gca aca gaa tgg att aca ttc     2746
 Gly Asp Cys Arg Ser Glu Asp Asp Glu Ala Thr Glu Trp Ile Thr Phe
             885                 890                 895

 cag gtc aaa cgt gta aag aaa ccc aaa gga gat cat aag aaa act cct     2794
 Gln Val Lys Arg Val Lys Lys Pro Lys Gly Asp His Lys Lys Thr Pro
         900                 905                 910

 ggg aaa aaa gta gaa aca ggt cag ata gaa aat gga cat cgt tac caa     2842
 Gly Lys Lys Val Glu Thr Gly Gln Ile Glu Asn Gly His Arg Tyr Gln
     915                 920                 925

 gca aac cta gag atc act ggc ccc aag gtg gca tct cct ggg cca caa     2890
 Ala Asn Leu Glu Ile Thr Gly Pro Lys Val Ala Ser Pro Gly Pro Gln
 930                 935                 940                 945

 ggg cta cta gac tgg aag acc agg aaa gtg cca tag acat aatgtaactg     2940
 Gly Leu Leu Asp Trp Lys Thr Arg Lys Val Pro 
                 950                 955

 gatttcagca aggcatttaa cagagcctct tatgatatcc ttgtgaacca gatggagaga   3000

 tgtgggcttg aagccttccc attgcctaca ggataaaatt caaacttcct agtgtggtgt   3060

 acaagaccct ttacagcccg cctctgtgta cccttcaaca ccattctctg aaccaaccat   3120

 gctcatgttt ttacctcagt gcctttgcac atgctattcc ctctgcctgg aatgccctgt   3180

 gccccctctg ccctctggcc gtgctaaaat atcactcatc cttaaacttc aaaatcaagt   3240

 gccatctctt ccttgttacc ttcaggcaga attagttact ctttcctctg tgcaattgtt   3300

 ctatatcttc gctctagctc ttttcctgtt gtattgtaat gatttgttta tgtttacctt   3360

 ccttactaga ctgtgagctc aagagcaggc cgtcttaatt attcctttct gtacccctag   3420

 tgtcttttat ggttctcagc cccttataac aggtgctcaa taaatatttt tcaaatccaa   3480

 ttattaaatg taaaagaaaa ttaataaaaa aaaaaaaaa                          3519




      <210> 163
      <211> 463
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (178)..(435)

      <400> 163
 gggactcatg agagtcatcg gtgttgtgtg aggcagctgt ttgttgattt tctggaccaa     60

 ataatgttcc accgtgtgac tggacatacc ttagtctatc cattctacca ctgatgagca    120

 tgtaagctgt tactattttt aactattaca aattatcttg ctaacacatt tttgtgc       177                                                                 
 atg tct ttt ggt gac caa atg gac tca ttt ctc tca ggt atg tat ctc      225
 Met Ser Phe Gly Asp Gln Met Asp Ser Phe Leu Ser Gly Met Tyr Leu
   1               5                  10                  15

 aga gtg aaa ctg ttt tat cac agt gta tgc ttt aca ttt agt gct ttc      273
 Arg Val Lys Leu Phe Tyr His Ser Val Cys Phe Thr Phe Ser Ala Phe
              20                  25                  30

 caa ttc ctg att aag aaa tct ttg cct gct cct aag gat gta aaa tta      321
 Gln Phe Leu Ile Lys Lys Ser Leu Pro Ala Pro Lys Asp Val Lys Leu
          35                  40                  45

 ttc tct tat ggc ctg gct cag tgg ctc atg cct gta atc cca gca ttt      369
 Phe Ser Tyr Gly Leu Ala Gln Trp Leu Met Pro Val Ile Pro Ala Phe
      50                  55                  60

 tgg gag gcc aag gtg gga gga ttg ctt gag gca agg agt tca aga cca      417
 Trp Glu Ala Lys Val Gly Gly Leu Leu Glu Ala Arg Ser Ser Arg Pro
  65                  70                  75                  80

 gcc tgg gca aca tac tga gaccctcatc tctacaaaaa aaaaaaaa               463
 Ala Trp Ala Thr Tyr 
                  85





      <210> 164
      <211> 7666
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (632)..(1552)

      <400> 164
 caagagtgcc tgaggctgga tcagaaatag ccacgatcgt ccagtttgat tgattgattg     60

 attgatttag ttgtgatgga gtctcgctgt atttcccagg ctggagtgca gaggcacgat    120

 ctccgttcac tgcagcctcc acctccccgg ttcaagtgat tctcctgcct cagccttccg    180

 agtagctggg attacaggca cctgccacca cgcccggctg atttttgtgt ttttagtaga    240

 gacagggttt cgccatgttg gccaggctgg tcttgaactc ctgacctcag gtgagccacc    300

 cgcctcggcc tcccaaagtg ttgggattac aggcgtgagc cactgccccc agccccagct    360

 tgatcttgaa cctcctgtgt gtgggcagag agacatggcc ctgctactgc ttgaacggct    420

 tccggagaca gtgacttgtt tcctttttcc ctctgaacta tgccgtaggg ccaggtgagc    480

 tgctgtgaag gactcattct tggtagccgg cagttactgg caacttgtga gcttggtggg    540

 ctcctactaa cgcacctggg acaccaggct gctgggctcc cctctaggca gcctcccctc    600

 caggcagcct caccagcagc tcccctgagc c   atg gag acc cca gag gtc ccc     652
                                      Met Glu Thr Pro Glu Val Pro
                                        1               5

 gtg ggc tcg cta atc gac ttt ggg cct gag gca ccc acc tct tct ccc      700
 Val Gly Ser Leu Ile Asp Phe Gly Pro Glu Ala Pro Thr Ser Ser Pro
          10                  15                  20

 ctg gag gca cca ccc cct gtg ctg cag gac ggc gat ggc tcc ctg ggg      748
 Leu Glu Ala Pro Pro Pro Val Leu Gln Asp Gly Asp Gly Ser Leu Gly
      25                  30                  35

 gac ggt gca tca gag agt gag acc act gag tct gcg gac agt gag aat      796
 Asp Gly Ala Ser Glu Ser Glu Thr Thr Glu Ser Ala Asp Ser Glu Asn
  40                  45                  50                  55

 gac atg ggc gag tcg ccc tcg cac ccg tcc tgg gac caa gac cgc cgt      844
 Asp Met Gly Glu Ser Pro Ser His Pro Ser Trp Asp Gln Asp Arg Arg
                  60                  65                  70

 tcc tcc tcc aac gag tcc ttc tcc tcc aac cag agc acc gag tct acc      892
 Ser Ser Ser Asn Glu Ser Phe Ser Ser Asn Gln Ser Thr Glu Ser Thr
              75                  80                  85

 cag gat gaa gag acc ctg gca ctc agg gac ttc atg cgt ggc tac gtg      940
 Gln Asp Glu Glu Thr Leu Ala Leu Arg Asp Phe Met Arg Gly Tyr Val
          90                  95                 100

 gag aag atc ttc tct gga ggg gag gac ttg gat cag gag gag aaa gcc      988
 Glu Lys Ile Phe Ser Gly Gly Glu Asp Leu Asp Gln Glu Glu Lys Ala
     105                 110                 115

 aag ttt gga gag tac tgc agc agt gaa aat gga aaa ggc cgg gag tgg     1036
 Lys Phe Gly Glu Tyr Cys Ser Ser Glu Asn Gly Lys Gly Arg Glu Trp
 120                 125                 130                 135

 ttt gct cga tac gtg agt gcc cag cgc tgc aac tcc aag tgt gtc tca     1084
 Phe Ala Arg Tyr Val Ser Ala Gln Arg Cys Asn Ser Lys Cys Val Ser
                 140                 145                 150

 gag gca acc ttc tac cgc ctg gtg cag tct ttt gca gtg gtg ctg ttc     1132
 Glu Ala Thr Phe Tyr Arg Leu Val Gln Ser Phe Ala Val Val Leu Phe
             155                 160                 165

 gag tgt cat cag atg gat gac ttt ggg cct gcc aag aac ctc atg acc     1180
 Glu Cys His Gln Met Asp Asp Phe Gly Pro Ala Lys Asn Leu Met Thr
         170                 175                 180

 atg tgc ttc acc tac tac cac atc gga aaa cca cag ctg ctg ccc ccg     1228
 Met Cys Phe Thr Tyr Tyr His Ile Gly Lys Pro Gln Leu Leu Pro Pro
     185                 190                 195

 gag tcc cgg gag aag ccc gcg ggc agc atc gac tcc tac ctg aaa tcc     1276
 Glu Ser Arg Glu Lys Pro Ala Gly Ser Ile Asp Ser Tyr Leu Lys Ser
 200                 205                 210                 215

 gca aac agc tgg ctg gcc gaa aag aag gac atc gcc gag cgg ctg ctg     1324
 Ala Asn Ser Trp Leu Ala Glu Lys Lys Asp Ile Ala Glu Arg Leu Leu
                 220                 225                 230

 aag aac acc tcg gcc agg act gag aat gtc aag ggc ttc ttc ggg ggg     1372
 Lys Asn Thr Ser Ala Arg Thr Glu Asn Val Lys Gly Phe Phe Gly Gly
             235                 240                 245

 ctg gag acc aag ctg aag ggg ccc ctg gcc agg agg aac gag gaa gac     1420
 Leu Glu Thr Lys Leu Lys Gly Pro Leu Ala Arg Arg Asn Glu Glu Asp
         250                 255                 260

 gag aac aaa ccc cag gag aag cgg ccc agg gct gtg acc gcg tac agc     1468
 Glu Asn Lys Pro Gln Glu Lys Arg Pro Arg Ala Val Thr Ala Tyr Ser
     265                 270                 275

 ccc gag gac gaa aag aag ggg gag aag atc tac ctg tac acg cac ctg     1516
 Pro Glu Asp Glu Lys Lys Gly Glu Lys Ile Tyr Leu Tyr Thr His Leu
 280                 285                 290                 295

 aag caa cag ccc atc tgg cac act ctg agg ttc tga gaag tggtgccaca     1566
 Lys Gln Gln Pro Ile Trp His Thr Leu Arg Phe 
                 300                 305

 tgacccagga ggagcgcgac gacagcctcc ggttcaacga gaacatcacc ttcgggcagc   1626

 tgggcacatt cacgcacaac atgctggcct ttggactgaa caagaagctg tgcaatgact   1686

 tcctgaagaa gcaggctgtg attggcaacc tggatgaaga gcaatacaag ctgcttagtg   1746

 accacattga gcaaatggcc actgagtagg ccccagaggt cgcactccgc aggaggactg   1806

 aggccatgtg ccattctccc gggcccagcg cccggccgtc accccacccg atgacctgca   1866

 tgaagccagc agcacccaga gccactcctg ctgccctaga actagcggtt agaagaatcc   1926

 gctgttcctc cctcatctcc tctgcctgtg tctgcgaccc ccatccatgt gccaaagtgt   1986

 cccttgggtc acacagctaa agccgaggtg accagttgta ccccgagtgc caggcttgtg   2046

 agatgagacc aagagggagg aggggaagga ctccatgggc catcgtgggc caagggctgg   2106

 cgagggtggg ggtgggcaag ggatgcaggc aggacagcca tgaggtgggg ctgcagccgg   2166

 cacacccagt ggtggagggc cggcgctgcc actcacggtg ggtggccgtg ggccaccttc   2226

 cctgcaatgg gtgcacacgc ggctcccatc cagccctctc agcgtggggc tgtggctggt   2286

 cctcactatt ccccagtctc ccgctgtggg gcaggaacag gaagtgacgg gaaccttgag   2346

 gaggaaacgc ctgtgttagg gagagagtgg gtgcggtgta gaggatgctc ttggccggct   2406

 ggagcaagac ctggctccca ccagagggac gtgtgtgtgc ctgcagacgg cccgggagct   2466

 gtgtgtctcc gccagagtca cagcagtgcc gaggtgtccg cggcagacca cacagaccgt   2526

 ctgaaatgcg cccgcctggc ggacagctcc cttctgaagc agagaagcct ccatggtcac   2586

 gaagcagcgt tgtgctgtgt gtccctcgca agaagcacag gaaagagaag tttctttagt   2646

 agccactaga caaccaccct ttctgaaagc aaacagtgct gctctttatt ccagacaagg   2706

 caggaaagtc tgagttggga gtgacagtgg ctggagagaa gcagatctgt gcaacgtgca   2766

 gggcaagcca gtggcgtggc ctctgcctct aagcgctgag cattgggccc cttccccacc   2826

 agacctttgt agctcctcca gcctctgcag agactccctt cacctcgcac ttactgcctg   2886

 ggaaccacgg cccttctctt ctgtgggtct gcaccaggta ctccaggcca gcccatgggc   2946

 ccggggcctg accccaacac ctgcatgctg ggtccagagc cttctgtttc accgtgcgtg   3006

 gacactgcta ggccgcctgg ggtcccctgc ctcctgcctg tcgctgccgt ggtccctgac   3066

 tgcgaaatag gcccgcgggg ctctccctcc tcctgccatc ctcccctccc gcccttcctg   3126

 gctacctcct ctgacatgcg gtcagataag tcccgtcttg tttgtgagta ccacagaaac   3186

 gcctgagagt cacttacccg gccactgctt ggaaggtttc cctccgggga atgcctccct   3246

 ggaatgttcc agagacggaa cattctctag agacaacagt ctgtgctgca gattggttgg   3306

 atcacagaat gtgtgtctgg ggcattatct gaaacgtggt gtcatctgat gcatttggac   3366

 catatgctgc cagactgcag aacgggggag ccggggctca gggcccctga ctgcatggtg   3426

 catgagtgat ctcagcctag cgatgccgct ggccagaccg tgaccatgct gccagtgtgc   3486

 tcgccatgag ctgggtcagg gctggggagt tgtgcaggct ggggtgaccc ttcccccatc   3546

 attgggcccc aacgggcatg tctccaccga atccatttag agaaatgtca gagcgagggg   3606

 tgtgtggaca cccctcgctc tgatgccaac tgcagataat acacacctcc tgcagcgtcc   3666

 agccacggct ccagggcact gctctcctcc ttgcaccggt gaaactcagg ccacactcaa   3726

 gggctgactg tccaggcgct cccttcagcc gcctcgtcgt cagcgttctt agtcatgcat   3786

 tattcgtgtt agctgaaatg cattcagact ttgttctgcg gtgcccacag gacttacccc   3846

 tgtatgtaca ggatttttgt atgaaagttt tgtttgattc tgagactctc ttgggaacgc   3906

 tggagagctt gtgcacagcc tctggaagga aaggcagcgc tgacttcgtt gggctttttt   3966

 ccaagcactt taacttcaga aatggtcttg acactttttt ctccacatag actcttgaaa   4026

 tagccatttc aggggaggaa agggttgggg ttttctttgt ttgtttgttt gtttccccct   4086

 ttactacctg ttcttgtaga tctagctcct cagagttgga ggaaggctga cagagaaggt   4146

 ctcctctgtg ctccatccac acaggatgcc ggagagacag ccccttgtgc tgtgagcaga   4206

 gcaggcagtg gctctggagg ctgcctgtgg tctccttcca gctgtggctg acagtggctc   4266

 tggccagggt tgcttggaga aggctcagtg tgcctgggac agggcttacc acctgccacc   4326

 aaggtttcct ctcttccccc aggacctggg cagagcaggc atgagctggg ctgtggtgca   4386

 gagcaagcag acccagccac actgctcaaa ggtccctgcg tggggaggtg tcacaccagg   4446

 ggcacaccca gggccacctg ggtgtaggag agctctggtg gcccctccgt aaactcagga   4506

 agtgtcaggt gatttcctag ggagaggttc ccagtcccag caggcagaat gcccaaaacc   4566

 aggagcacga aggcctgtca tccatggggc cattgcaggc accctgccgc ccgaccttga   4626

 gggctgtgcc aatcctagtg aaccaaaatg caaacaactc acacaagtga aaagctccct   4686

 gctttgaaaa caggacatgt tgacaggcag catggtatgt ttttagcctt tgttacagtt   4746

 ttagcaacat tgatgtctaa gaggggccgt ggtaatagat tgcatctgcc ctgtgcatgc   4806

 gcatgtttaa ccacaggcca gagaactcaa ttctgatgtc gtaagttctc tgtaagtgaa   4866

 atggggtaga ctgtatgatt ttcctattgc caaaagaaag aaagggggcc aaacagctct   4926

 gaaatttcca aaaaatggct agagggagag tccagtttct gagctctgta cccaaattaa   4986

 aatcctgatg ttcaggttaa tccaagcaac acgcattggg tttaaaacca gcaccgaggc   5046

 ccagtggggg aatcacagac atcaccaagt ctcgtcttct ttccttcctg tgagttgaaa   5106

 ccaaacaggc ctctcgctca ctcctcccag cccagtaatg ctgaggagtt cagttgtgag   5166

 gaaagaaggc tggagctgtg agattcgctt ttccctaggc tgttccgcgt gggttacctt   5226

 atcaccctgg agcacttggt attccagacc cctgacatga ggaatgcagg ttcacactgt   5286

 aaagagtttg tgaaaggttt cagtctaact ggggttcctt agctggaagc cagggctgga   5346

 agctacaggc ctgaccttcc tgggtcccac tatctgttgg catttttttt tttttttttt   5406

 agacggagtt ttgctcttgt tgcccaggct ggagtgcagt gacacaatct ctactcactg   5466

 caacctccac ctcccgggtt caagcaattc tcctgcctca gcctcctgag tagctgggat   5526

 gacaggtgca cgccaccacg cccggctaat ttttatattt ttggtagaga tggggtttca   5586

 ccatgctggc caggctggtc tcgaactcct gacctcaggt gatccccccc acctcagcct   5646

 cccaaagtgc tgggattaca ggcgtgaggc atcacacctg cctctgttgg ctttttagtt   5706

 aggaaggatc cagctaggcc cgtgtggtta gatcagcttt gttactgaat tacctaaaac   5766

 cagaccacag cacagccagg gagcccagta gtgtttccaa gaacagtgtg gagcttgaga   5826

 aagagaactt taaaaattag agggtccctt tctgcagagg aagggatgct cgcagggtgg   5886

 cagtggccca gccccagcct cagggacggg gagggagagc cccctctggg cccagcaggc   5946

 aggtgttctg aggctggtcc ctcctcagtt tccgcagcca caaggcgaaa cggccagatt   6006

 ctcactcaag gtcgttctca ctccttttcc tgtcccgttt ccagtcccac tgagccattc   6066

 acttctgctg aaccattttt cttaggatgc agccgtctca ctcccttgtc ctgtaaatcg   6126

 tgtattcatg ttgatgattc ttggagatag gtttcacttt ttcccagctg cgtccacagg   6186

 aaaggggagt cggatgccag ctgcaccccg cctggctcgc acaggctaag accacagaca   6246

 gagcagggct tcccggagcc acacaggcca cgcaccccag gaacccttgc tgctgcgggc   6306

 caggaacagg aatgtgttgg tgcctgagac accaaatgga agaagcacat caagactgtt   6366

 ctcctgcggc caacactggc ccggaagccg ccctccatac aggccctcag ggggcctgcc   6426

 ttctgcgcct cagtcccccg tgcatccctg ggcctgggta tcacatgctc tccaggaaag   6486

 ggacggaatc aatcgtgtga ccgatgggct cgcaaggatg ggtgccgccg tgggagccct   6546

 gcctctggtg ctggcaaggg attgggtttg tgtgggtgtc tctagcctgc agagtgcagt   6606

 gagtgagagt ccttgggagc gcggcgctgc ctgtagctgc gcctggggat gcacgtggcc   6666

 acgggatttc agtgggacag cgctcccaca ggggctgggg gtgggggtgg ggtttcttag   6726

 ttactgttgg aaagggaaaa attcaccata tccaagggga gagacgatgg gctgggtttg   6786

 tttactccaa cttcccttct acacccctcc tgcagaacag tacgatttgg ggagaaccca   6846

 gctccccact ttatctgcag actctgggac ctgacaaaac agtcagagcc tgagtgcact   6906

 gcagcctgaa ctcccttgag cagcgctata agggactttg cactttaaaa aggggatgcc   6966

 tgtcagtaaa tcccctgtgc attgactaga actggggggc tgcgcccgct ccctccttaa   7026

 tcctagatga tttgctcatg aaatagaggt gggggacgac cgcatgcact ctgggaggtg   7086

 cagccctaag gggtggactc cagatctccc tgcaagagac agcttggctt ggctttggct   7146

 gttggggagg agtccctgcc atcccggtga gcctggggct gttgcttagg gtcttctggg   7206

 tggacacgtg gagaaagaga aggcaaacgt tggaacacta ggaaaagcta gaaattcaga   7266

 caacacacat ggatcccctt aaaacatgta aatgtgtcag aacacggttg acctgccgcc   7326

 ttcttgaacc tggtggcccc cgttggaact atcagtggcg tctcccatgc acacgccctc   7386

 tgctttctct ttcctagact cgcggtgctc acatccagac attaccttgt tggtagcccc   7446

 caagtggcgt gcagtgacac cagtatcttc tctgttgcat ttttgcaatc ttgtgtcccg   7506

 ctcggtgatg ttctacaaac tctgttttaa ggttgagaaa gtttcaaggg tgaagatctc   7566

 aaaacagtgc taaaatcaaa ggtgtttgct gtgaagaaaa acatgtgtat atattgcacc   7626

 ttgagttgtc agaaggtaga aactgaaata aactaacttt                         7666




      <210> 165
      <211> 1280
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (203)..(1174)

      <400> 165
 gtaaggaatc atggtcagga gtcatgaaaa aaatgccaac acactgagat ggccacacat     60

 cttcactctt gcactagttt ttggggttat cttctgctat cctgtcttga agctcttttt    120

 cagctagata ccttgacttt tctgaaaaac taaaaccaga agcatttcac gaagctaagc    180

 acaggacaga aggtttgctg gg atg gga aac ctg ctc aaa gtc ctt acc agg     232
                          Met Gly Asn Leu Leu Lys Val Leu Thr Arg
                            1               5                  10

 gaa att gaa aac tat cca cac ttt ttc ctg gat ttt gaa aat gct cag      280
 Glu Ile Glu Asn Tyr Pro His Phe Phe Leu Asp Phe Glu Asn Ala Gln
                  15                  20                  25

 cct aca gaa gga gag aga gaa atc tgg aac cag atc agc gcc gtc ctt      328
 Pro Thr Glu Gly Glu Arg Glu Ile Trp Asn Gln Ile Ser Ala Val Leu
              30                  35                  40

 cag gat tct gag agc atc ctt gca gac ctg cag gct tac aaa ggc gca      376
 Gln Asp Ser Glu Ser Ile Leu Ala Asp Leu Gln Ala Tyr Lys Gly Ala
          45                  50                  55

 ggc cta gag atc cga gat gca att caa aat ccc aat gac att cag ctt      424
 Gly Leu Glu Ile Arg Asp Ala Ile Gln Asn Pro Asn Asp Ile Gln Leu
      60                  65                  70

 caa gaa aaa gct tgg aat gcg gtg tgc cct ctt gtt gtg agg cta aag      472
 Gln Glu Lys Ala Trp Asn Ala Val Cys Pro Leu Val Val Arg Leu Lys
  75                  80                  85                  90

 aga ttt tac gag ttt tcc att aga cta gaa aaa gct ctt cag agt tta      520
 Arg Phe Tyr Glu Phe Ser Ile Arg Leu Glu Lys Ala Leu Gln Ser Leu
                  95                 100                 105

 ttg gaa tct ctg act tgt cca ccc tac aca cca acc caa cac ctg gaa      568
 Leu Glu Ser Leu Thr Cys Pro Pro Tyr Thr Pro Thr Gln His Leu Glu
             110                 115                 120

 agg gaa cag gcc ctg gca aag gag ttt gcc gaa att tta cat ttt acc      616
 Arg Glu Gln Ala Leu Ala Lys Glu Phe Ala Glu Ile Leu His Phe Thr
         125                 130                 135

 ctt cga ttc gat gag ctg aag atg agg aac ccg gct att cag aat gac      664
 Leu Arg Phe Asp Glu Leu Lys Met Arg Asn Pro Ala Ile Gln Asn Asp
     140                 145                 150

 ttc agc tac tac aga aga aca atc agt cgc aac cgc atc aac aac atg      712
 Phe Ser Tyr Tyr Arg Arg Thr Ile Ser Arg Asn Arg Ile Asn Asn Met
 155                 160                 165                 170

 cac cta gac att gag aat gaa gtc aat aat gag atg gcc aat cga atg      760
 His Leu Asp Ile Glu Asn Glu Val Asn Asn Glu Met Ala Asn Arg Met
                 175                 180                 185

 tcc ctc ttc tat gca gaa gcc acg cca atg ctg aaa acc ctt agc aat      808
 Ser Leu Phe Tyr Ala Glu Ala Thr Pro Met Leu Lys Thr Leu Ser Asn
             190                 195                 200

 gcc aca atg cac ttt gtc tct gaa aac aaa act ttg cca ata gag aac      856
 Ala Thr Met His Phe Val Ser Glu Asn Lys Thr Leu Pro Ile Glu Asn
         205                 210                 215

 acc aca gac tgc ctc agc aca atg aca agt gtc tgt aaa gtc atg ctg      904
 Thr Thr Asp Cys Leu Ser Thr Met Thr Ser Val Cys Lys Val Met Leu
     220                 225                 230

 gaa act ccg gag tac aga agt agg ttt acg agt gaa gag acc ctg atg      952
 Glu Thr Pro Glu Tyr Arg Ser Arg Phe Thr Ser Glu Glu Thr Leu Met
 235                 240                 245                 250

 ttc tgc atg agg gtg atg gtg gga gtc atc atc ctc tat gac cat gtc     1000
 Phe Cys Met Arg Val Met Val Gly Val Ile Ile Leu Tyr Asp His Val
                 255                 260                 265

 cac cct gtg gga gct ttc tgc aag aca tcc aag atc gat atg aaa ggc     1048
 His Pro Val Gly Ala Phe Cys Lys Thr Ser Lys Ile Asp Met Lys Gly
             270                 275                 280

 tgc ata aaa gtt ttg aag gag cag gcc cca gac agt gtg gag ggg ctg     1096
 Cys Ile Lys Val Leu Lys Glu Gln Ala Pro Asp Ser Val Glu Gly Leu
         285                 290                 295

 cta aat gcc ctc agg ttc act aca aag cac ttg aac gat gaa tca act     1144
 Leu Asn Ala Leu Arg Phe Thr Thr Lys His Leu Asn Asp Glu Ser Thr
     300                 305                 310

 tcc aaa cag att cga gca atg ctt cag tag a gctctgctca aagaagagga     1195
 Ser Lys Gln Ile Arg Ala Met Leu Gln 
 315                 320

 tctatgtgct gacctcagaa gatgtatatg tttacataat ttaatacaga ttgatgttaa   1255

 tacttgtgta tttaaaaaaa aaaaa                                         1280




      <210> 166
      <211> 2038
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (669)..(929)

      <400> 166
 tacctatcga cccagcttgc acgaggcgtg tgaaaaaaaa actgtgctac ttacaatcta     60

 tgaaagctgg tattatccca cttggcaggt aaggaaactg aggtcctgtg agtgaagtga    120

 cctcatgatc acacaacagg agatggcagg gctgggattc aaacccggga gtgtctgctg    180

 ccacatccca cactcccact gcctggctcc aagtcccagg aagctcgaga ctgtgagttt    240

 tctcccttga aactcacctg gagagaggcc gggcacctgt gcctatgtgg agggttccag    300

 ccccagccag gcccctccgc tgcccacacc ctgggaggag aagcggcctc ccttccaggc    360

 tcatctgctc actgccggca ttctcctggc agagctgagg tctgagagat ctggactcca    420

 acccaagggc cctctcttgt tattcagggg tgtccacagt tagggaggga cctggggcct    480

 tgtcccacca ccttcctagg ccccgtgatc accaccccct caagcggggc cccagccccc    540

 tgagcacccc ctcacgtgac ccagccctcg gctgttccag gctcactgcc catggtgtgc    600

 tcttctgggc cacagcagcc agggctccag ggcgaggacg ggggacacct gaaaacaccc    660

 cgttgttc atg gtc ttg tgc cca ttc att cgg aga ctc ctg aaa aac tgg     710
          Met Val Leu Cys Pro Phe Ile Arg Arg Leu Leu Lys Asn Trp
            1               5                  10

 gct gtt tgc aaa gca aat cca gct cct tgt cct agc agg ttc tca gaa      758
 Ala Val Cys Lys Ala Asn Pro Ala Pro Cys Pro Ser Arg Phe Ser Glu
  15                  20                  25                  30

 cgg gga gtc ccc tgg gat gga gct gct ccc ctc acg gca gca cca cgt      806
 Arg Gly Val Pro Trp Asp Gly Ala Ala Pro Leu Thr Ala Ala Pro Arg
                  35                  40                  45

 ttc cag tcc ctc gat gcc act aat cag cat gga ctg tgt tca gga cac      854
 Phe Gln Ser Leu Asp Ala Thr Asn Gln His Gly Leu Cys Ser Gly His
              50                  55                  60

 agg gtg aac ttt tct ctg acc ccc ggt gct ggt cct gtg cca gca cgt      902
 Arg Val Asn Phe Ser Leu Thr Pro Gly Ala Gly Pro Val Pro Ala Arg
          65                  70                  75

 agt agt tac tca gta gag gtt tgc tga gtaaa ccagaaatca gattatgagt      954
 Ser Ser Tyr Ser Val Glu Val Cys 
      80                  85

 gttcaggggt ttgataaaac agcaccacat aacgcacaca aagatactcc agaaacattt   1014

 gctgagtacc tagtacgtgt gaggtgctgt gaggatagag cagagaggac tgtgccccag   1074

 ctgtgatgct ggcagaggtg acactaagag ggaaatgaga tatttggggc agaatccact   1134

 gggctctctt ggccatccgc tgccttgggt ctgttgaggt gggtgcccaa aggctgcctt   1194

 cttgaccaga acctgctgtg cgcttcacag aacctcctct tcattggaaa tgctgggcac   1254

 attgcagtca gtgagctgct gccaaaacgg cgttaagtag aacccccaga ggccccgccg   1314

 gttggtgatc accctcaggt cctgccaggg agacacagtg aggaggttgg ctaattgctg   1374

 ctttcaggcc ctggaaatca gtcgccaagg cccaggagaa ccccggtgag tccgtccagt   1434

 tgaggcagag gcaataacct cccattgctc ggccctgcgc ctgccccagt cctggcaggg   1494

 ggcaccggct caggaacatg cggcctcctg gcatttctcg gtatttaact gtctcgctgt   1554

 cttatccgag tccctaatga aacgacttgt gtgacaatct gtctgtgcct tacgaaagtg   1614

 tctgtgcact ttttatcctt tttaaaagca acttttaaaa gtggatgggg aggggggcta   1674

 gcatacgtgg tagggttcta gaaatctgtg gtcatcgctg aaatcctttt tgcatcatgt   1734

 tttttgatgt tggagtgatg aagtgtacat cccccacccc acacaccact acctgtgtac   1794

 agacctttta aaacatgtct tctttttctg attcaatact gtgacctctc cgatacagtc   1854

 taatccttgg ggatctgtaa tcaaggtttt aaaacctggg aagtgggttg ggaagggttt   1914

 gcactggtct tgagtgttgt gcttttctgt gttgtgtgtt ttgatttttg tctttttatc   1974

 tgttttatat tgacataatt ttcctgttta aaaaaataca actttggctt gttaaaaaaa   2034

 aaaa                                                                2038




      <210> 167
      <211> 1486
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (692)..(1255)

      <400> 167
 atgtcagcag tgtgctggct ctttggacgt cacctttatg acactctgca gtatcccatc     60

 gggctgatcg cctccagctg gggcgggaca cccattgaag cctggtcatc tggacggtca    120

 ctgaaagcct gtggggtccc taaacaaggg tacttgctaa agaagctcct ccagcttcag    180

 gctctaactg aaggggaagt acaggctgca gctccttccc acagttccag tttgcccctg    240

 acttatggtg tggccagctc tgtgggaact atacagggag ctgggcctat ttcagggccc    300

 agcactgggg ctgaggaacc atttgggaag aaaactaaga aggagaaaaa agaaaaaggc    360

 aaagagaaca acaaactgga agttctgaag aaaacatgca agaaaaagaa aatggcggga    420

 ggtgctcgca agctggttca gcccattgcc ctggatccct caggacggcc tgtgttcccc    480

 atcggactag ggggtctaac agtatatagc ctgggggagc cccaaagtgg ttctaaaggc    540

 taccacagga aactggactt ctaaattctt cagtgacctc aatcccaggt tgggggaatg    600

 ttttttatag atcatcaccg accgacctgg ctttcatgat gagagtgcca tctaccccgt    660

 gggctattgc agtactcgaa tatatgccag c   atg aag tgc cca gac cag aag     712
                                      Met Lys Cys Pro Asp Gln Lys
                                        1               5

 tgt cta tat acc tgt cag atc aag gat ggt ggt gtg cag cct cag ttt      760
 Cys Leu Tyr Thr Cys Gln Ile Lys Asp Gly Gly Val Gln Pro Gln Phe
          10                  15                  20

 gaa att gtt cct gaa gat gac ccc cag aat gcc att gtc agc tct tct      808
 Glu Ile Val Pro Glu Asp Asp Pro Gln Asn Ala Ile Val Ser Ser Ser
      25                  30                  35

 gca gat gct tgt cat gca gaa ctg ctc agg act ata agc act act atg      856
 Ala Asp Ala Cys His Ala Glu Leu Leu Arg Thr Ile Ser Thr Thr Met
  40                  45                  50                  55

 ggg aaa cta atg cct aac ctg ctt cca gct gga gct gac ttt ttt gga      904
 Gly Lys Leu Met Pro Asn Leu Leu Pro Ala Gly Ala Asp Phe Phe Gly
                  60                  65                  70

 ttt tct cat cca gcc atc cac aac ctg atc cag agc tgt cca gga gct      952
 Phe Ser His Pro Ala Ile His Asn Leu Ile Gln Ser Cys Pro Gly Ala
              75                  80                  85

 cga aaa tgc atc aat tac cag tgg gtg aaa ttt gat gtg tgc aaa cct     1000
 Arg Lys Cys Ile Asn Tyr Gln Trp Val Lys Phe Asp Val Cys Lys Pro
          90                  95                 100

 gga gat ggg cag cta cct gag ggg ctg ccg gag aat gat gca gct atg     1048
 Gly Asp Gly Gln Leu Pro Glu Gly Leu Pro Glu Asn Asp Ala Ala Met
     105                 110                 115

 agc ttt gaa gcc ttt cag aga cag atc ttt gat gaa gat cag aat gat     1096
 Ser Phe Glu Ala Phe Gln Arg Gln Ile Phe Asp Glu Asp Gln Asn Asp
 120                 125                 130                 135

 ccc ctt ctg cca gga tcc ttg gac ctc cca gag ctt cag cct gca gcc     1144
 Pro Leu Leu Pro Gly Ser Leu Asp Leu Pro Glu Leu Gln Pro Ala Ala
                 140                 145                 150

 ttt gtg tct tct tac cag ccc atg tac ctg aca cat gaa ccc ttg gta     1192
 Phe Val Ser Ser Tyr Gln Pro Met Tyr Leu Thr His Glu Pro Leu Val
             155                 160                 165

 gat act cac ctg cag cac ttg aag tct cca tca cag ggt agc cca att     1240
 Asp Thr His Leu Gln His Leu Lys Ser Pro Ser Gln Gly Ser Pro Ile
         170                 175                 180

 cag tct tca gat tga acaagaaggg atcagatgcc acatcgtttt tgtcgtgatt     1295
 Gln Ser Ser Asp 
     185

 aatttaactt aaactaaaat tttgggtata tgaaagaagg cagcaattca gaagtaaaga   1355

 agatactaac gtatttcatc atggaaggtc ctgtggtgat ggttttccct gggaaaacct   1415

 tcagctgctt tatttttagt aataaatttc tcttgtcaat tctgtttact ttcatcttgt   1475

 aaaaaaaaaa a                                                        1486




      <210> 168
      <211> 357
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (19)..(222)

      <400> 168
 tctaagcaga tgtaggtg  atg agc ggc ccg gca gcc acc acg ttt cat tgg      51
                      Met Ser Gly Pro Ala Ala Thr Thr Phe His Trp
                        1               5                  10

 aaa aag tgc aga ttg gat ttg cca ggg cat gta gct ctc cag gct tgc       99
 Lys Lys Cys Arg Leu Asp Leu Pro Gly His Val Ala Leu Gln Ala Cys
              15                  20                  25

 aag cga tta cca gat gaa cac aat cac gta cag aag aaa acc ttt acc      147
 Lys Arg Leu Pro Asp Glu His Asn His Val Gln Lys Lys Thr Phe Thr
          30                  35                  40

 aaa tgg ata aat gct cga ttt tca aag gta act gag act ttc aaa aac      195
 Lys Trp Ile Asn Ala Arg Phe Ser Lys Val Thr Glu Thr Phe Lys Asn
      45                  50                  55

 ttc gat ggt tca gat gcg gca ttc tga ttgaa ggagtttggt tggaagtgca      247
 Phe Asp Gly Ser Asp Ala Ala Phe 
  60                  65

 gtgaattttc cccaggaaat gtcacctagc cgaagtcttc tgagtatgca gatacatttg    307

 ttgttccttt attctgtcct aaaatatgtt taaacggaaa ttctcatgcc               357




      <210> 169
      <211> 3092
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2943)

      <400> 169
  atg gag att gta act gag gaa aaa gga gag tta gtg tta cac aga tat      48
  Met Glu Ile Val Thr Glu Glu Lys Gly Glu Leu Val Leu His Arg Tyr
    1               5                  10                  15

 tat tta tct aaa aaa tca caa ccg gaa aaa gtc tgg ctt gat caa aag       96
 Tyr Leu Ser Lys Lys Ser Gln Pro Glu Lys Val Trp Leu Asp Gln Lys
              20                  25                  30

 gaa gat gat aaa aaa tac atg aag agg gta cac tct cct aca aaa cca      144
 Glu Asp Asp Lys Lys Tyr Met Lys Arg Val His Ser Pro Thr Lys Pro
          35                  40                  45

 gcc agt tac tca gta aag tgg acg ata gaa gaa aaa gag ctg ttt gaa      192
 Ala Ser Tyr Ser Val Lys Trp Thr Ile Glu Glu Lys Glu Leu Phe Glu
      50                  55                  60

 caa ggg ctg cct ggg gca att tat agg tat cgg cag aag agg tct ggg      240
 Gln Gly Leu Pro Gly Ala Ile Tyr Arg Tyr Arg Gln Lys Arg Ser Gly
  65                  70                  75                  80

 cag tat ggc ttg ctg ccc agc agg aca ttg ata aga tgt tcc cat gat      288
 Gln Tyr Gly Leu Leu Pro Ser Arg Thr Leu Ile Arg Cys Ser His Asp
                  85                  90                  95

 gag gca gtt ctg gcc ctt gtt ccg gcg gga tgt cgt tgt ggt gtt cag      336
 Glu Ala Val Leu Ala Leu Val Pro Ala Gly Cys Arg Cys Gly Val Gln
             100                 105                 110

 gct aaa ttt ggc cga aga tgg acc aaa att tca aag cta att gga agc      384
 Ala Lys Phe Gly Arg Arg Trp Thr Lys Ile Ser Lys Leu Ile Gly Ser
         115                 120                 125

 cgc act gtt tta caa gtg aag agt tat gca aga cag tat ttt aaa aat      432
 Arg Thr Val Leu Gln Val Lys Ser Tyr Ala Arg Gln Tyr Phe Lys Asn
     130                 135                 140

 aag gtc aaa tgc ggt ctg gat aaa gaa aca cca aat cag aag acc ggc      480
 Lys Val Lys Cys Gly Leu Asp Lys Glu Thr Pro Asn Gln Lys Thr Gly
 145                 150                 155                 160

 cat aat ctt caa gtt aaa aat gaa gat aaa ggg aca aag gca tgg aca      528
 His Asn Leu Gln Val Lys Asn Glu Asp Lys Gly Thr Lys Ala Trp Thr
                 165                 170                 175

 cca tca tgt tta agg gga cgt gct gat ccc aac ttg aat gct gta aaa      576
 Pro Ser Cys Leu Arg Gly Arg Ala Asp Pro Asn Leu Asn Ala Val Lys
             180                 185                 190

 att gaa aag tta tct gat gat gaa gaa gta gac atc aca gat gag gtg      624
 Ile Glu Lys Leu Ser Asp Asp Glu Glu Val Asp Ile Thr Asp Glu Val
         195                 200                 205

 gac gag ttg tct tct caa aca ccc cag aag aat tct agc agt gat ctc      672
 Asp Glu Leu Ser Ser Gln Thr Pro Gln Lys Asn Ser Ser Ser Asp Leu
     210                 215                 220

 ttg tta gac ttt cct aat agt aaa atg cat gaa acc aat caa gga gaa      720
 Leu Leu Asp Phe Pro Asn Ser Lys Met His Glu Thr Asn Gln Gly Glu
 225                 230                 235                 240

 ttc att gct tct gac agc cag gaa gct ctc ttt tct aag tct tcc agg      768
 Phe Ile Ala Ser Asp Ser Gln Glu Ala Leu Phe Ser Lys Ser Ser Arg
                 245                 250                 255

 ggc tgt ctt caa aat gaa aag caa gat gaa aca ctt tca agc tca gaa      816
 Gly Cys Leu Gln Asn Glu Lys Gln Asp Glu Thr Leu Ser Ser Ser Glu
             260                 265                 270

 att aca ctg tgg act gag aaa cag agc aat ggt gac aaa aaa tca att      864
 Ile Thr Leu Trp Thr Glu Lys Gln Ser Asn Gly Asp Lys Lys Ser Ile
         275                 280                 285

 gaa tta aat gac cag aaa ttt aat gaa ttg att aaa aac tgc aac aag      912
 Glu Leu Asn Asp Gln Lys Phe Asn Glu Leu Ile Lys Asn Cys Asn Lys
     290                 295                 300

 cat gat gga agg gga ata ata gtt gat gcc agg cag ttg cct tct cca      960
 His Asp Gly Arg Gly Ile Ile Val Asp Ala Arg Gln Leu Pro Ser Pro
 305                 310                 315                 320

 gag cct tgt gaa att cag aaa aat ttg aat gat aat gaa atg ctt ttt     1008
 Glu Pro Cys Glu Ile Gln Lys Asn Leu Asn Asp Asn Glu Met Leu Phe
                 325                 330                 335

 cat tct tgc caa atg gta gag gaa agc cat gag gaa gaa gag ctt aag     1056
 His Ser Cys Gln Met Val Glu Glu Ser His Glu Glu Glu Glu Leu Lys
             340                 345                 350

 cca cca gaa cag gaa ata gaa ata gat aga aat atc att caa gaa gaa     1104
 Pro Pro Glu Gln Glu Ile Glu Ile Asp Arg Asn Ile Ile Gln Glu Glu
         355                 360                 365

 gaa aaa caa gca att cct gag ttt ttt gag ggg cgc caa gct aaa aca     1152
 Glu Lys Gln Ala Ile Pro Glu Phe Phe Glu Gly Arg Gln Ala Lys Thr
     370                 375                 380

 cca gaa cgc tat ttg aaa att aga aat tat att ttg gat caa tgg gag     1200
 Pro Glu Arg Tyr Leu Lys Ile Arg Asn Tyr Ile Leu Asp Gln Trp Glu
 385                 390                 395                 400

 ata tgc aaa cca aaa tac tta aat aag acc tca gta cgt cct ggc ctg     1248
 Ile Cys Lys Pro Lys Tyr Leu Asn Lys Thr Ser Val Arg Pro Gly Leu
                 405                 410                 415

 aag aac tgt gga gat gtt aat tgt att gga cgg att cat aca tac ctc     1296
 Lys Asn Cys Gly Asp Val Asn Cys Ile Gly Arg Ile His Thr Tyr Leu
             420                 425                 430

 gaa ttg ata gga gca atc aat ttt gga tgt gaa cag gct gtg tat aat     1344
 Glu Leu Ile Gly Ala Ile Asn Phe Gly Cys Glu Gln Ala Val Tyr Asn
         435                 440                 445

 agg cca caa aca gtt gac aaa gta cga atc aga gac aga aaa gat gca     1392
 Arg Pro Gln Thr Val Asp Lys Val Arg Ile Arg Asp Arg Lys Asp Ala
     450                 455                 460

 gta gaa gca tac caa ctt gcc cag cgt ctg cag tct atg cgt aca agg     1440
 Val Glu Ala Tyr Gln Leu Ala Gln Arg Leu Gln Ser Met Arg Thr Arg
 465                 470                 475                 480

 aga cgt agg gtc cga gac cca tgg gga aac tgg tgt gat gca aag gac     1488
 Arg Arg Arg Val Arg Asp Pro Trp Gly Asn Trp Cys Asp Ala Lys Asp
                 485                 490                 495

 tta gaa gga caa acg ttt gag gag cca ttt cag gtg aaa gtg gct tca     1536
 Leu Glu Gly Gln Thr Phe Glu Glu Pro Phe Gln Val Lys Val Ala Ser
             500                 505                 510

 gaa gca ctt tta ata atg gat ttg cat gct cat gtt tct atg gca gaa     1584
 Glu Ala Leu Leu Ile Met Asp Leu His Ala His Val Ser Met Ala Glu
         515                 520                 525

 gtg att ggt ctg tta gga gga aga tac tca gaa gtt gat aaa gta gtt     1632
 Val Ile Gly Leu Leu Gly Gly Arg Tyr Ser Glu Val Asp Lys Val Val
     530                 535                 540

 gaa gtc tgt gca gca gaa cca tgt aac agt ctg agt aca gga cta cag     1680
 Glu Val Cys Ala Ala Glu Pro Cys Asn Ser Leu Ser Thr Gly Leu Gln
 545                 550                 555                 560

 tgt gag atg gat cct gta tca caa aca cag gcc tca gaa acc ttg gct     1728
 Cys Glu Met Asp Pro Val Ser Gln Thr Gln Ala Ser Glu Thr Leu Ala
                 565                 570                 575

 gtt aga ggc ttc agt gtt att gga tgg tat cat tct cat cct gct ttt     1776
 Val Arg Gly Phe Ser Val Ile Gly Trp Tyr His Ser His Pro Ala Phe
             580                 585                 590

 gat cct aat cct tcc tta cga gat att gac aca caa gct aaa tac cag     1824
 Asp Pro Asn Pro Ser Leu Arg Asp Ile Asp Thr Gln Ala Lys Tyr Gln
         595                 600                 605

 agt tac ttc tcc aga gga ggt gca aag ttc att ggg atg att gtt agt     1872
 Ser Tyr Phe Ser Arg Gly Gly Ala Lys Phe Ile Gly Met Ile Val Ser
     610                 615                 620

 ccc tat aat cga aat aat ccc tta cca tat tct cag att acc tgc ctg     1920
 Pro Tyr Asn Arg Asn Asn Pro Leu Pro Tyr Ser Gln Ile Thr Cys Leu
 625                 630                 635                 640

 gtt ata agt gag gaa att agc cca gat ggc tct tat cgc tta cct tac     1968
 Val Ile Ser Glu Glu Ile Ser Pro Asp Gly Ser Tyr Arg Leu Pro Tyr
                 645                 650                 655

 aaa ttt gaa gta cag cag atg tta gaa gaa cct cag tgg gga tta gta     2016
 Lys Phe Glu Val Gln Gln Met Leu Glu Glu Pro Gln Trp Gly Leu Val
             660                 665                 670

 ttt gaa aag aca aga tgg ata ata gaa aaa tac agg ctc tcc cat agg     2064
 Phe Glu Lys Thr Arg Trp Ile Ile Glu Lys Tyr Arg Leu Ser His Arg
         675                 680                 685

 agt ggg gtt gag gtc tgt gac atg cag act gta agc aca gtc aga acc     2112
 Ser Gly Val Glu Val Cys Asp Met Gln Thr Val Ser Thr Val Arg Thr
     690                 695                 700

 tct gca gct ctc aac cca aca gag gag act gtg gct tca aca tgc caa     2160
 Ser Ala Ala Leu Asn Pro Thr Glu Glu Thr Val Ala Ser Thr Cys Gln
 705                 710                 715                 720

 cct gag cag gtc tcc tct gca tta cct tcc tcc cat ttc tct tcc tgg     2208
 Pro Glu Gln Val Ser Ser Ala Leu Pro Ser Ser His Phe Ser Ser Trp
                 725                 730                 735

 gtc ctg atg agg ctg cta cag gta ata gct aca tgc cct aaa gcc cca     2256
 Val Leu Met Arg Leu Leu Gln Val Ile Ala Thr Cys Pro Lys Ala Pro
             740                 745                 750

 gtt gct cag atg gaa ggc tcc atg ccc agt gag tac agg agg gcc ggt     2304
 Val Ala Gln Met Glu Gly Ser Met Pro Ser Glu Tyr Arg Arg Ala Gly
         755                 760                 765

 aaa ggc acc cag gca ccc aga ttg gct gaa aac ttc tgt gtc tgc cat     2352
 Lys Gly Thr Gln Ala Pro Arg Leu Ala Glu Asn Phe Cys Val Cys His
     770                 775                 780

 tta gct act ggg gac atg ctg agg gcc atg gtg gct tct ggc tca gag     2400
 Leu Ala Thr Gly Asp Met Leu Arg Ala Met Val Ala Ser Gly Ser Glu
 785                 790                 795                 800

 cta gga aaa aag ctg aag gca act atg gat gct ggg aaa ctg gtg agt     2448
 Leu Gly Lys Lys Leu Lys Ala Thr Met Asp Ala Gly Lys Leu Val Ser
                 805                 810                 815

 gat gaa atg gta gtg gag ctc att gag aag aat ttg gag acc ccc ttg     2496
 Asp Glu Met Val Val Glu Leu Ile Glu Lys Asn Leu Glu Thr Pro Leu
             820                 825                 830

 tgc aaa aat ggt ttt ctt ctg gat ggc ttc cct cgg act gtg agg cag     2544
 Cys Lys Asn Gly Phe Leu Leu Asp Gly Phe Pro Arg Thr Val Arg Gln
         835                 840                 845

 gca gaa atg ctc gat gac ctc atg gag aag agg aaa gag aag ctt gat     2592
 Ala Glu Met Leu Asp Asp Leu Met Glu Lys Arg Lys Glu Lys Leu Asp
     850                 855                 860

 tct gtg att gaa ttc agc atc cca gac tct ctg ctg atc cga aga atc     2640
 Ser Val Ile Glu Phe Ser Ile Pro Asp Ser Leu Leu Ile Arg Arg Ile
 865                 870                 875                 880

 aca gga agg ctg att cac ccc aag agt ggc cgt tcc tac cac gag gag     2688
 Thr Gly Arg Leu Ile His Pro Lys Ser Gly Arg Ser Tyr His Glu Glu
                 885                 890                 895

 ttc aac cct cca aaa gag ccc atg aaa gat gac atc acc ggg gaa ccc     2736
 Phe Asn Pro Pro Lys Glu Pro Met Lys Asp Asp Ile Thr Gly Glu Pro
             900                 905                 910

 ttg atc cgt cga tca gat gat aat gaa aag gcc ttg aaa atc cgc ctg     2784
 Leu Ile Arg Arg Ser Asp Asp Asn Glu Lys Ala Leu Lys Ile Arg Leu
         915                 920                 925

 caa gcc tac cac act caa acc acc cca ctc ata gag tac tac agg aaa     2832
 Gln Ala Tyr His Thr Gln Thr Thr Pro Leu Ile Glu Tyr Tyr Arg Lys
     930                 935                 940

 cgg ggg atc cac tcc gcc atc gat gca tcc cag acc ccc gat gtc gtg     2880
 Arg Gly Ile His Ser Ala Ile Asp Ala Ser Gln Thr Pro Asp Val Val
 945                 950                 955                 960

 ttc gca agc atc cta gca gcc ttc tcc aaa gcc aca tgt aaa gac ttg     2928
 Phe Ala Ser Ile Leu Ala Ala Phe Ser Lys Ala Thr Cys Lys Asp Leu
                 965                 970                 975

 gtt atg ttt atc taa tgttgggtcc aagaaggaat ttctttccat ccctgtgagg     2983
 Val Met Phe Ile 
             980

 caatgggtgg gaatgatagg acaggcaaag agaagcttcc tcaggctagc aaaaatatca   3043

 tttgatgtat tgattaaaaa agcacttgct tgatgtaaaa aaaaaaaaa               3092




      <210> 170
      <211> 13375
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(12294)

      <400> 170
  atg gcg ggc tcc gga gcc ggt gtg cgt tgc tcc ctg ctg cgg ctg cag      48
  Met Ala Gly Ser Gly Ala Gly Val Arg Cys Ser Leu Leu Arg Leu Gln
    1               5                  10                  15

 gag acc ttg tcc gct gcg gac cgc tgc ggt gct gcc ctg gcc ggt cat       96
 Glu Thr Leu Ser Ala Ala Asp Arg Cys Gly Ala Ala Leu Ala Gly His
              20                  25                  30

 caa ctg atc cgc ggc ctg ggg cag gaa tgc gtc ctg agc agc agc ccc      144
 Gln Leu Ile Arg Gly Leu Gly Gln Glu Cys Val Leu Ser Ser Ser Pro
          35                  40                  45

 gcg gtg ctg gca tta cag aca tct tta gtt ttt tcc aga gat ttc ggt      192
 Ala Val Leu Ala Leu Gln Thr Ser Leu Val Phe Ser Arg Asp Phe Gly
      50                  55                  60

 ttg ctt gta ttt gtc cgg aag tca ctc aac agt att gaa ttt cgt gaa      240
 Leu Leu Val Phe Val Arg Lys Ser Leu Asn Ser Ile Glu Phe Arg Glu
  65                  70                  75                  80

 tgt aga gaa gaa atc cta aag ttt tta tgt att ttc tta gaa aaa atg      288
 Cys Arg Glu Glu Ile Leu Lys Phe Leu Cys Ile Phe Leu Glu Lys Met
                  85                  90                  95

 ggc cag aag atc gca cct tac tct gtt gaa att aag aac act tgt acc      336
 Gly Gln Lys Ile Ala Pro Tyr Ser Val Glu Ile Lys Asn Thr Cys Thr
             100                 105                 110

 agt gtt tat aca aaa gat aga gct gct aaa tgt aaa att cca gcc ctg      384
 Ser Val Tyr Thr Lys Asp Arg Ala Ala Lys Cys Lys Ile Pro Ala Leu
         115                 120                 125

 gac ctt ctt att aag tta ctt cag act ttt aga agt tct aga ctc atg      432
 Asp Leu Leu Ile Lys Leu Leu Gln Thr Phe Arg Ser Ser Arg Leu Met
     130                 135                 140

 gat gaa ttt aaa att gga gaa tta ttt agt aaa ttc tat gga gaa ctt      480
 Asp Glu Phe Lys Ile Gly Glu Leu Phe Ser Lys Phe Tyr Gly Glu Leu
 145                 150                 155                 160

 gca ttg aaa aaa aaa ata cca gat aca gtt tta gaa aaa gta tat gag      528
 Ala Leu Lys Lys Lys Ile Pro Asp Thr Val Leu Glu Lys Val Tyr Glu
                 165                 170                 175

 ctc cta gga tta ttg ggt gaa gtt cat cct agt gag atg ata aat aat      576
 Leu Leu Gly Leu Leu Gly Glu Val His Pro Ser Glu Met Ile Asn Asn
             180                 185                 190

 gca gaa aac ctg ttc cgc gct ttt ctg ggt gaa ctt aag acc cag atg      624
 Ala Glu Asn Leu Phe Arg Ala Phe Leu Gly Glu Leu Lys Thr Gln Met
         195                 200                 205

 aca tca gca gta aga gag ccc aaa cta cct gtt ctg gca gga tgt ctg      672
 Thr Ser Ala Val Arg Glu Pro Lys Leu Pro Val Leu Ala Gly Cys Leu
     210                 215                 220

 aag ggg ttg tcc tca ctt ctg tgc aac ttc act aag tcc atg gaa gaa      720
 Lys Gly Leu Ser Ser Leu Leu Cys Asn Phe Thr Lys Ser Met Glu Glu
 225                 230                 235                 240

 gat ccc cag act tca agg gag att ttt aat ttt gta cta aag gca att      768
 Asp Pro Gln Thr Ser Arg Glu Ile Phe Asn Phe Val Leu Lys Ala Ile
                 245                 250                 255

 cgt cct cag att gat ctg aag aga tat gct gtg ccc tca gct ggc ttg      816
 Arg Pro Gln Ile Asp Leu Lys Arg Tyr Ala Val Pro Ser Ala Gly Leu
             260                 265                 270

 cgc cta ttt gcc ctg cat gca tct cag ttt agc acc tgc ctt ctg gac      864
 Arg Leu Phe Ala Leu His Ala Ser Gln Phe Ser Thr Cys Leu Leu Asp
         275                 280                 285

 aac tac gtg tct cta ttt gaa gtc ttg tta aag tgg tgt gcc cac aca      912
 Asn Tyr Val Ser Leu Phe Glu Val Leu Leu Lys Trp Cys Ala His Thr
     290                 295                 300

 aat gta gaa ttg aaa aaa gct gca ctt tca gcc ctg gaa tcc ttt ctg      960
 Asn Val Glu Leu Lys Lys Ala Ala Leu Ser Ala Leu Glu Ser Phe Leu
 305                 310                 315                 320

 aaa cag gtt tct aat atg gtg gcg aaa aat gca gaa atg cat aaa aat     1008
 Lys Gln Val Ser Asn Met Val Ala Lys Asn Ala Glu Met His Lys Asn
                 325                 330                 335

 aaa ctg cag tac ttt atg gag cag ttt tat gga atc atc aga aat gtg     1056
 Lys Leu Gln Tyr Phe Met Glu Gln Phe Tyr Gly Ile Ile Arg Asn Val
             340                 345                 350

 gat tcg aac aac aag gag tta tct att gct atc cgt gga tat gga ctt     1104
 Asp Ser Asn Asn Lys Glu Leu Ser Ile Ala Ile Arg Gly Tyr Gly Leu
         355                 360                 365

 ttt gca gga ccg tgc aag gtt ata aac gca aaa gat gtt gac ttc atg     1152
 Phe Ala Gly Pro Cys Lys Val Ile Asn Ala Lys Asp Val Asp Phe Met
     370                 375                 380

 tac gtt gag ctc att cag cgc tgc aag cag atg ttc ctc acc cag aca     1200
 Tyr Val Glu Leu Ile Gln Arg Cys Lys Gln Met Phe Leu Thr Gln Thr
 385                 390                 395                 400

 gac act ggt gac tac cgt gtt tat cag atg cca agc ttc ctc cag tct     1248
 Asp Thr Gly Asp Tyr Arg Val Tyr Gln Met Pro Ser Phe Leu Gln Ser
                 405                 410                 415

 gtt gca agc gtc ttg ctg tac ctt gac aca gtt cct gag gtg tat act     1296
 Val Ala Ser Val Leu Leu Tyr Leu Asp Thr Val Pro Glu Val Tyr Thr
             420                 425                 430

 cca gtt ctg gag cac ctc gtg gtg atg cag ata gac agt ttc cca cag     1344
 Pro Val Leu Glu His Leu Val Val Met Gln Ile Asp Ser Phe Pro Gln
         435                 440                 445

 tac agt cca aaa atg cag ctg gtg tgt tgc aga gcc ata gtg aag gtg     1392
 Tyr Ser Pro Lys Met Gln Leu Val Cys Cys Arg Ala Ile Val Lys Val
     450                 455                 460

 ttc cta gct ttg gca gca aaa ggg cca gtt ctc agg aat tgc att agt     1440
 Phe Leu Ala Leu Ala Ala Lys Gly Pro Val Leu Arg Asn Cys Ile Ser
 465                 470                 475                 480

 act gtg gtg cat cag ggt tta atc aga ata tgt tct aaa cca gtg gtc     1488
 Thr Val Val His Gln Gly Leu Ile Arg Ile Cys Ser Lys Pro Val Val
                 485                 490                 495

 ctt cca aag ggc cct gag tct gaa tct gaa gac cac cgt gct tca ggg     1536
 Leu Pro Lys Gly Pro Glu Ser Glu Ser Glu Asp His Arg Ala Ser Gly
             500                 505                 510

 gaa gtc aga act ggc aaa tgg aag gtg ccc aca tac aaa gac tac gtg     1584
 Glu Val Arg Thr Gly Lys Trp Lys Val Pro Thr Tyr Lys Asp Tyr Val
         515                 520                 525

 gat ctc ttc aga cat ctc ctg agc tct gac cag atg atg gat tct att     1632
 Asp Leu Phe Arg His Leu Leu Ser Ser Asp Gln Met Met Asp Ser Ile
     530                 535                 540

 tta gca gat gaa gca ttt ttc tct gtg aat tcc tcc agt gaa agt ctg     1680
 Leu Ala Asp Glu Ala Phe Phe Ser Val Asn Ser Ser Ser Glu Ser Leu
 545                 550                 555                 560

 aat cat tta ctt tat gat gaa ttt gta aaa tcc gtt ttg aag att gtt     1728
 Asn His Leu Leu Tyr Asp Glu Phe Val Lys Ser Val Leu Lys Ile Val
                 565                 570                 575

 gag aaa ttg gat ctt aca ctt gaa ata cag act gtt ggg gaa caa gag     1776
 Glu Lys Leu Asp Leu Thr Leu Glu Ile Gln Thr Val Gly Glu Gln Glu
             580                 585                 590

 aat gga gat gag gcg cct ggt gtt tgg atg atc cca act tca gat cca     1824
 Asn Gly Asp Glu Ala Pro Gly Val Trp Met Ile Pro Thr Ser Asp Pro
         595                 600                 605

 gcg gct aac ttg cat cca gct aaa cct aaa gat ttt tcg gct ttc att     1872
 Ala Ala Asn Leu His Pro Ala Lys Pro Lys Asp Phe Ser Ala Phe Ile
     610                 615                 620

 aac ctg gtg gaa ttt tgc aga gag att ctc cct gag aaa caa gca gaa     1920
 Asn Leu Val Glu Phe Cys Arg Glu Ile Leu Pro Glu Lys Gln Ala Glu
 625                 630                 635                 640

 ttt ttt gaa cca tgg gtg tac tca ttt tca tat gaa tta att ttg caa     1968
 Phe Phe Glu Pro Trp Val Tyr Ser Phe Ser Tyr Glu Leu Ile Leu Gln
                 645                 650                 655

 tct aca agg ttg ccc ctc atc agt ggt ttc tac aaa ttg ctt tct att     2016
 Ser Thr Arg Leu Pro Leu Ile Ser Gly Phe Tyr Lys Leu Leu Ser Ile
             660                 665                 670

 aca gta aga aat gcc aag aaa ata aaa tat ttc gag gga gtt agt cca     2064
 Thr Val Arg Asn Ala Lys Lys Ile Lys Tyr Phe Glu Gly Val Ser Pro
         675                 680                 685

 aag agt ctg aaa cac tct cct gaa gac cca gaa aag tat tct tgc ttt     2112
 Lys Ser Leu Lys His Ser Pro Glu Asp Pro Glu Lys Tyr Ser Cys Phe
     690                 695                 700

 gct tta ttt gtg aaa ttt ggc aaa gag gtg gca gtt aaa atg aag cag     2160
 Ala Leu Phe Val Lys Phe Gly Lys Glu Val Ala Val Lys Met Lys Gln
 705                 710                 715                 720

 tac aaa gat gaa ctt ttg gcc tct tgt ttg acc ttt ctt ctg tcc ttg     2208
 Tyr Lys Asp Glu Leu Leu Ala Ser Cys Leu Thr Phe Leu Leu Ser Leu
                 725                 730                 735

 cca cac aac atc att gaa ctc gat gtt aga gcc tac gtt cct gca ctg     2256
 Pro His Asn Ile Ile Glu Leu Asp Val Arg Ala Tyr Val Pro Ala Leu
             740                 745                 750

 cag atg gct ttc aaa ctg ggc ctg agc tat acc ccc ttg gca gaa gta     2304
 Gln Met Ala Phe Lys Leu Gly Leu Ser Tyr Thr Pro Leu Ala Glu Val
         755                 760                 765

 ggc ctg aat gct cta gaa gaa tgg tca att tat att gac aga cat gta     2352
 Gly Leu Asn Ala Leu Glu Glu Trp Ser Ile Tyr Ile Asp Arg His Val
     770                 775                 780

 atg cag cct tat tac aaa gac att ctc ccc tgc ctg gat gga tac ctg     2400
 Met Gln Pro Tyr Tyr Lys Asp Ile Leu Pro Cys Leu Asp Gly Tyr Leu
 785                 790                 795                 800

 aag act tca gcc ttg tca gat gag acc aag aat aac tgg gaa gtg tca     2448
 Lys Thr Ser Ala Leu Ser Asp Glu Thr Lys Asn Asn Trp Glu Val Ser
                 805                 810                 815

 gct ctt tct cgg gct gcc cag aaa gga ttt aat aaa gtg gtg tta aag     2496
 Ala Leu Ser Arg Ala Ala Gln Lys Gly Phe Asn Lys Val Val Leu Lys
             820                 825                 830

 cat ctg aag aag aca aag aac ctt tca tca aac gaa gca ata tcc tta     2544
 His Leu Lys Lys Thr Lys Asn Leu Ser Ser Asn Glu Ala Ile Ser Leu
         835                 840                 845

 gaa gaa ata aga att aga gta gta caa atg ctt gga tct cta gga gga     2592
 Glu Glu Ile Arg Ile Arg Val Val Gln Met Leu Gly Ser Leu Gly Gly
     850                 855                 860

 caa ata aac aaa aat ctt ctg aca gtc acg tcc tca gat gag atg atg     2640
 Gln Ile Asn Lys Asn Leu Leu Thr Val Thr Ser Ser Asp Glu Met Met
 865                 870                 875                 880

 aag agc tat gtg gcc tgg gac aga gag aag cgg ctg agc ttt gca gtg     2688
 Lys Ser Tyr Val Ala Trp Asp Arg Glu Lys Arg Leu Ser Phe Ala Val
                 885                 890                 895

 ccc ttt aga gag atg aaa cct gtc att ttc ctg gat gtg ttc ctg cct     2736
 Pro Phe Arg Glu Met Lys Pro Val Ile Phe Leu Asp Val Phe Leu Pro
             900                 905                 910

 cga gtc aca gaa tta gcg ctc aca gcc agt gac aga caa act aaa gtt     2784
 Arg Val Thr Glu Leu Ala Leu Thr Ala Ser Asp Arg Gln Thr Lys Val
         915                 920                 925

 gca gcc tgt gaa ctt tta cat agc atg gtt atg ttt atg ttg ggc aaa     2832
 Ala Ala Cys Glu Leu Leu His Ser Met Val Met Phe Met Leu Gly Lys
     930                 935                 940

 gcc acg cag atg cca gaa ggg gga cag gga gcc cca ccc atg tac cag     2880
 Ala Thr Gln Met Pro Glu Gly Gly Gln Gly Ala Pro Pro Met Tyr Gln
 945                 950                 955                 960

 ctc tat aag cgg acg ttt cct gtg ctg ctt cga ctt gcg tgt gat gtt     2928
 Leu Tyr Lys Arg Thr Phe Pro Val Leu Leu Arg Leu Ala Cys Asp Val
                 965                 970                 975

 gat cag gtg aca agg caa ctg tat gag cca cta gtt atg cag ctg att     2976
 Asp Gln Val Thr Arg Gln Leu Tyr Glu Pro Leu Val Met Gln Leu Ile
             980                 985                 990

 cac tgg ttc act aac aac aag aaa ttt gaa agt cag gat act gtt tcc     3024
 His Trp Phe Thr Asn Asn Lys Lys Phe Glu Ser Gln Asp Thr Val Ser
         995                1000                1005

 tta cta gaa gct ata ttg gat gga att gtg gac cct gtt gac agt act     3072
 Leu Leu Glu Ala Ile Leu Asp Gly Ile Val Asp Pro Val Asp Ser Thr
    1010                1015                1020

 tta aga gat ttt tgt ggt cgg tgt att cga gaa ttc ctt aaa tgg tcc     3120
 Leu Arg Asp Phe Cys Gly Arg Cys Ile Arg Glu Phe Leu Lys Trp Ser
1025                1030                1035                1040

 att aag caa ata aca cca cag cag cag gag aag agt cca gta aac acc     3168
 Ile Lys Gln Ile Thr Pro Gln Gln Gln Glu Lys Ser Pro Val Asn Thr
                1045                1050                1055

 aaa tcg ctt ttc aag cga ctt tat agc ctt gcg ctt cac ccc aat gct     3216
 Lys Ser Leu Phe Lys Arg Leu Tyr Ser Leu Ala Leu His Pro Asn Ala
            1060                1065                1070

 ttc aag agg ctg gga gca tca ctt gcc ttt aat aat atc tac agg gaa     3264
 Phe Lys Arg Leu Gly Ala Ser Leu Ala Phe Asn Asn Ile Tyr Arg Glu
        1075                1080                1085

 ttc agg gaa gaa gag tct ctg gtg gaa cag ttt gtg ttt gaa gcc ttg     3312
 Phe Arg Glu Glu Glu Ser Leu Val Glu Gln Phe Val Phe Glu Ala Leu
    1090                1095                1100

 gtg ata tac atg gag agt ctg gcc tta gca cat gca gat gag aag tcc     3360
 Val Ile Tyr Met Glu Ser Leu Ala Leu Ala His Ala Asp Glu Lys Ser
1105                1110                1115                1120

 tta ggt aca att caa cag tgt tgt gat gcc att gat cac cta tgc cgc     3408
 Leu Gly Thr Ile Gln Gln Cys Cys Asp Ala Ile Asp His Leu Cys Arg
                1125                1130                1135

 atc att gaa aag aag cat gtt tct tta aat aaa gca aag aaa cga cgt     3456
 Ile Ile Glu Lys Lys His Val Ser Leu Asn Lys Ala Lys Lys Arg Arg
            1140                1145                1150

 ttg ccg cga gga ttt cca cct tcc gca tca ttg tgt tta ttg gat ctg     3504
 Leu Pro Arg Gly Phe Pro Pro Ser Ala Ser Leu Cys Leu Leu Asp Leu
        1155                1160                1165

 gtc aag tgg ctt tta gct cat tgt ggg agg ccc cag aca gaa tgt cga     3552
 Val Lys Trp Leu Leu Ala His Cys Gly Arg Pro Gln Thr Glu Cys Arg
    1170                1175                1180

 cac aaa tcc att gaa ctc ttt tat aaa ttc gtt cct tta ttg cca ggc     3600
 His Lys Ser Ile Glu Leu Phe Tyr Lys Phe Val Pro Leu Leu Pro Gly
1185                1190                1195                1200

 aac aga tcc cct aat ttg tgg ctg aaa gat gtt ctc aag gaa gaa ggt     3648
 Asn Arg Ser Pro Asn Leu Trp Leu Lys Asp Val Leu Lys Glu Glu Gly
                1205                1210                1215

 gtc tct ttt ctc atc aac acc ttt gag ggg ggt ggc tgt ggc cag ccc     3696
 Val Ser Phe Leu Ile Asn Thr Phe Glu Gly Gly Gly Cys Gly Gln Pro
            1220                1225                1230

 tcg ggc atc ctg gcc cag ccc acc ctc ttg tac ctt cgg ggg cca ttc     3744
 Ser Gly Ile Leu Ala Gln Pro Thr Leu Leu Tyr Leu Arg Gly Pro Phe
        1235                1240                1245

 agc ctg cag gcc acg cta tgc tgg ctg gac ctg ctc ctg gcc gcg ttg     3792
 Ser Leu Gln Ala Thr Leu Cys Trp Leu Asp Leu Leu Leu Ala Ala Leu
    1250                1255                1260

 gag tgc tac aac acg ttc att ggc gag aga act gta gga gcg ctc cag     3840
 Glu Cys Tyr Asn Thr Phe Ile Gly Glu Arg Thr Val Gly Ala Leu Gln
1265                1270                1275                1280

 gtc cta ggt act gaa gcc cag tct tca ctt ttg aaa gca gtg gct ttc     3888
 Val Leu Gly Thr Glu Ala Gln Ser Ser Leu Leu Lys Ala Val Ala Phe
                1285                1290                1295

 ttc tta gaa agc att gcc atg cat gac att ata gca gca gaa aag tgc     3936
 Phe Leu Glu Ser Ile Ala Met His Asp Ile Ile Ala Ala Glu Lys Cys
            1300                1305                1310

 ttt ggc act ggg gca gca ggt aac aga aca agc cca caa gag gga gaa     3984
 Phe Gly Thr Gly Ala Ala Gly Asn Arg Thr Ser Pro Gln Glu Gly Glu
        1315                1320                1325

 agg tac aac tac agc aaa tgc acc gtt gtg gtc cgg att atg gag ttt     4032
 Arg Tyr Asn Tyr Ser Lys Cys Thr Val Val Val Arg Ile Met Glu Phe
    1330                1335                1340

 acc acg act ctg cta aac acc tcc ccg gaa gga tgg aag ctc ctg aag     4080
 Thr Thr Thr Leu Leu Asn Thr Ser Pro Glu Gly Trp Lys Leu Leu Lys
1345                1350                1355                1360

 aag gac ttg tgt aat aca cac ctg atg aga gtc ctg gtg cag acg ctg     4128
 Lys Asp Leu Cys Asn Thr His Leu Met Arg Val Leu Val Gln Thr Leu
                1365                1370                1375

 tgt gag ccc gca agc ata ggt ttc aac atc gga gac gtc cag gtt atg     4176
 Cys Glu Pro Ala Ser Ile Gly Phe Asn Ile Gly Asp Val Gln Val Met
            1380                1385                1390

 gct cat ctt cct gat gtt tgt gtg aat ctg atg aaa gct cta aag atg     4224
 Ala His Leu Pro Asp Val Cys Val Asn Leu Met Lys Ala Leu Lys Met
        1395                1400                1405

 tcc cca tac aaa gat atc cta gag acc cat ctg aga gag aaa ata aca     4272
 Ser Pro Tyr Lys Asp Ile Leu Glu Thr His Leu Arg Glu Lys Ile Thr
    1410                1415                1420

 gca cag agc att gag gag ctt tgt gcc gtc aac ttg tat ggc cct gac     4320
 Ala Gln Ser Ile Glu Glu Leu Cys Ala Val Asn Leu Tyr Gly Pro Asp
1425                1430                1435                1440

 gcg caa gtg gac agg agc agg ctg gct gct gtt gtg tct gcc tgt aaa     4368
 Ala Gln Val Asp Arg Ser Arg Leu Ala Ala Val Val Ser Ala Cys Lys
                1445                1450                1455

 cag ctt cac aga gct ggg ctt ctg cat aat ata tta ccg tct cag tcc     4416
 Gln Leu His Arg Ala Gly Leu Leu His Asn Ile Leu Pro Ser Gln Ser
            1460                1465                1470

 aca gat ttg cat cat tct gtt ggc aca gaa ctt ctt tcc ctg gtt tat     4464
 Thr Asp Leu His His Ser Val Gly Thr Glu Leu Leu Ser Leu Val Tyr
        1475                1480                1485

 aaa ggc att gcc cct gga gat gag aga cag tgt ctg cct tct cta gac     4512
 Lys Gly Ile Ala Pro Gly Asp Glu Arg Gln Cys Leu Pro Ser Leu Asp
    1490                1495                1500

 ctc agt tgt aag cag ctg gcc agc gga ctt ctg gag tta gcc ttt gct     4560
 Leu Ser Cys Lys Gln Leu Ala Ser Gly Leu Leu Glu Leu Ala Phe Ala
1505                1510                1515                1520

 ttt gga gga ctg tgt gag cgc ctt gtg agt ctt ctc ctg aac cca gcg     4608
 Phe Gly Gly Leu Cys Glu Arg Leu Val Ser Leu Leu Leu Asn Pro Ala
                1525                1530                1535

 gtg ctg tcc acg gcg tcc ttg ggc agc tca cag ggc agc gtc atc cac     4656
 Val Leu Ser Thr Ala Ser Leu Gly Ser Ser Gln Gly Ser Val Ile His
            1540                1545                1550

 ttc tcc cat ggg gag tat ttc tat agc ttg ttc tca gaa acg atc aac     4704
 Phe Ser His Gly Glu Tyr Phe Tyr Ser Leu Phe Ser Glu Thr Ile Asn
        1555                1560                1565

 acg gaa tta ttg aaa aat ctg gat ctt gct gta ttg gag ctc atg cag     4752
 Thr Glu Leu Leu Lys Asn Leu Asp Leu Ala Val Leu Glu Leu Met Gln
    1570                1575                1580

 tct tca gtg gat aat acc aaa atg gtg agt gcc gtt ttg aac ggc atg     4800
 Ser Ser Val Asp Asn Thr Lys Met Val Ser Ala Val Leu Asn Gly Met
1585                1590                1595                1600

 tta gac cag agc ttc agg gag cga gca aac cag aaa cac caa gga ctg     4848
 Leu Asp Gln Ser Phe Arg Glu Arg Ala Asn Gln Lys His Gln Gly Leu
                1605                1610                1615

 aaa ctt gcg act aca att ctg caa cac tgg aag aag tgt gat tca tgg     4896
 Lys Leu Ala Thr Thr Ile Leu Gln His Trp Lys Lys Cys Asp Ser Trp
            1620                1625                1630

 tgg gcc aaa gat tcc cct ctc gaa act aaa atg gca gtg ctg gcc tta     4944
 Trp Ala Lys Asp Ser Pro Leu Glu Thr Lys Met Ala Val Leu Ala Leu
        1635                1640                1645

 ctg gca aaa att tta cag att gat tca tct gta tct ttt aat aca agt     4992
 Leu Ala Lys Ile Leu Gln Ile Asp Ser Ser Val Ser Phe Asn Thr Ser
    1650                1655                1660

 cat ggt tca ttc cct gaa gtc ttt aca aca tat att agt cta ctt gct     5040
 His Gly Ser Phe Pro Glu Val Phe Thr Thr Tyr Ile Ser Leu Leu Ala
1665                1670                1675                1680

 gac aca aag ctg gat cta cat tta aag ggc caa gct gtc act ctt ctt     5088
 Asp Thr Lys Leu Asp Leu His Leu Lys Gly Gln Ala Val Thr Leu Leu
                1685                1690                1695

 cca ttc ttc acc agc ctc act gga ggc agt ctg gag gaa ctt aga cgt     5136
 Pro Phe Phe Thr Ser Leu Thr Gly Gly Ser Leu Glu Glu Leu Arg Arg
            1700                1705                1710

 gtt ctg gag cag ctc atc gtt gct cac ttc ccc atg cag tcc agg gaa     5184
 Val Leu Glu Gln Leu Ile Val Ala His Phe Pro Met Gln Ser Arg Glu
        1715                1720                1725

 ttt cct cca gga act ccg cgg ttc aat aat tat gtg gac tgc atg aaa     5232
 Phe Pro Pro Gly Thr Pro Arg Phe Asn Asn Tyr Val Asp Cys Met Lys
    1730                1735                1740

 aag ttt cta gat gca ttg gaa tta tct caa agc cct atg ttg ttg gaa     5280
 Lys Phe Leu Asp Ala Leu Glu Leu Ser Gln Ser Pro Met Leu Leu Glu
1745                1750                1755                1760

 ttg atg aca gaa gtt ctt tgt cgg gaa cag cag cat gtc atg gaa gaa     5328
 Leu Met Thr Glu Val Leu Cys Arg Glu Gln Gln His Val Met Glu Glu
                1765                1770                1775

 tta ttt caa tcc agt ttc agg agg att gcc aga agg ggt tca tgt gtc     5376
 Leu Phe Gln Ser Ser Phe Arg Arg Ile Ala Arg Arg Gly Ser Cys Val
            1780                1785                1790

 aca caa gta ggc ctt ctg gaa agc gtg tat gaa atg ttc agg aag gat     5424
 Thr Gln Val Gly Leu Leu Glu Ser Val Tyr Glu Met Phe Arg Lys Asp
        1795                1800                1805

 gac ccc cgc cta agt ttc aca cgc cag tcc ttt gtg gac cgc tcc ctc     5472
 Asp Pro Arg Leu Ser Phe Thr Arg Gln Ser Phe Val Asp Arg Ser Leu
    1810                1815                1820

 ctc act ctg ctg tgg cac tgt agc ctg gat gct ttg aga gaa ttc ttc     5520
 Leu Thr Leu Leu Trp His Cys Ser Leu Asp Ala Leu Arg Glu Phe Phe
1825                1830                1835                1840

 agc aca att gtg gtg gat gcc att gat gtg ttg aag tcc agg ttt aca     5568
 Ser Thr Ile Val Val Asp Ala Ile Asp Val Leu Lys Ser Arg Phe Thr
                1845                1850                1855

 aag cta aat gaa tct acc ttt gat act caa atc acc aag aag atg ggc     5616
 Lys Leu Asn Glu Ser Thr Phe Asp Thr Gln Ile Thr Lys Lys Met Gly
            1860                1865                1870

 tac tat aag att cta gac gtg atg tat tct cgc ctt ccc aaa gat gat     5664
 Tyr Tyr Lys Ile Leu Asp Val Met Tyr Ser Arg Leu Pro Lys Asp Asp
        1875                1880                1885

 gtt cat gct aag gaa tca aaa att aat caa gtt ttc cat ggc tcg tgt     5712
 Val His Ala Lys Glu Ser Lys Ile Asn Gln Val Phe His Gly Ser Cys
    1890                1895                1900

 att aca gaa gga aat gaa ctt aca aag aca ttg att aaa ttg tgc tac     5760
 Ile Thr Glu Gly Asn Glu Leu Thr Lys Thr Leu Ile Lys Leu Cys Tyr
1905                1910                1915                1920

 gat gca ttt aca gag aac atg gca gga gag aat cag ctg ctg gag agg     5808
 Asp Ala Phe Thr Glu Asn Met Ala Gly Glu Asn Gln Leu Leu Glu Arg
                1925                1930                1935

 aga aga ctt tac cat tgt gca gca tac aac tgc gcc ata tct gtc atc     5856
 Arg Arg Leu Tyr His Cys Ala Ala Tyr Asn Cys Ala Ile Ser Val Ile
            1940                1945                1950

 tgc tgt gtc ttc aat gag tta aaa ttt tac caa ggt ttt ctg ttt agt     5904
 Cys Cys Val Phe Asn Glu Leu Lys Phe Tyr Gln Gly Phe Leu Phe Ser
        1955                1960                1965

 gaa aaa cca gaa aag aac ttg ctt att ttt gaa aat ctg atc gac ctg     5952
 Glu Lys Pro Glu Lys Asn Leu Leu Ile Phe Glu Asn Leu Ile Asp Leu
    1970                1975                1980

 aag cgc cgc tat aat ttt cct gta gaa gtt gag gtt cct atg gaa aga     6000
 Lys Arg Arg Tyr Asn Phe Pro Val Glu Val Glu Val Pro Met Glu Arg
1985                1990                1995                2000

 aag aaa aag tac att gaa att agg aaa gaa gcc aga gaa gca gca aat     6048
 Lys Lys Lys Tyr Ile Glu Ile Arg Lys Glu Ala Arg Glu Ala Ala Asn
                2005                2010                2015

 ggg gat tca gat ggt cct tcc tat atg tct tcc ctg tca tat ttg gca     6096
 Gly Asp Ser Asp Gly Pro Ser Tyr Met Ser Ser Leu Ser Tyr Leu Ala
            2020                2025                2030

 gac agt acc ctg agt gag gaa atg agt caa ttt gat ttc tca acc gga     6144
 Asp Ser Thr Leu Ser Glu Glu Met Ser Gln Phe Asp Phe Ser Thr Gly
        2035                2040                2045

 gtt cag agc tat tca tac agc tcc caa gac cct aga cct gcc act ggt     6192
 Val Gln Ser Tyr Ser Tyr Ser Ser Gln Asp Pro Arg Pro Ala Thr Gly
    2050                2055                2060

 cgt ttt cgg aga cgg gag cag cgg gac ccc acg gtg cat gat gat gtg     6240
 Arg Phe Arg Arg Arg Glu Gln Arg Asp Pro Thr Val His Asp Asp Val
2065                2070                2075                2080

 ctg gag ctg gag atg gac gag ctc aat cgg cat gag tgc atg gcg ccc     6288
 Leu Glu Leu Glu Met Asp Glu Leu Asn Arg His Glu Cys Met Ala Pro
                2085                2090                2095

 ctg acg gcc ctg gtc aag cac atg cac aga agc ctg ggc ccg cct caa     6336
 Leu Thr Ala Leu Val Lys His Met His Arg Ser Leu Gly Pro Pro Gln
            2100                2105                2110

 gga gaa gag gat tca gtg cca aga gat ctt cct tct tgg atg aaa ttc     6384
 Gly Glu Glu Asp Ser Val Pro Arg Asp Leu Pro Ser Trp Met Lys Phe
        2115                2120                2125

 ctc cat ggc aaa ctg gga aat cca ata gta cca tta aat atc cgt ctc     6432
 Leu His Gly Lys Leu Gly Asn Pro Ile Val Pro Leu Asn Ile Arg Leu
    2130                2135                2140

 ttc tta gcc aag ctt gtt att aat aca gaa gag gtc ttt cgc cct tac     6480
 Phe Leu Ala Lys Leu Val Ile Asn Thr Glu Glu Val Phe Arg Pro Tyr
2145                2150                2155                2160

 gcg aag cac tgg ctt agc ccc ttg ctg cag ctg gct gct tct gaa aac     6528
 Ala Lys His Trp Leu Ser Pro Leu Leu Gln Leu Ala Ala Ser Glu Asn
                2165                2170                2175

 aat gga gga gaa gga att cac tac atg gtg gtt gag ata gtg gcc act     6576
 Asn Gly Gly Glu Gly Ile His Tyr Met Val Val Glu Ile Val Ala Thr
            2180                2185                2190

 att ctt tca tgg aca ggc ttg gcc act cca aca ggg gtc cct aaa gat     6624
 Ile Leu Ser Trp Thr Gly Leu Ala Thr Pro Thr Gly Val Pro Lys Asp
        2195                2200                2205

 gaa gtg tta gca aat cga ttg ctt aat ttc cta atg aaa cat gtc ttt     6672
 Glu Val Leu Ala Asn Arg Leu Leu Asn Phe Leu Met Lys His Val Phe
    2210                2215                2220

 cat cca aaa aga gct gtg ttt aga cac aac ctt gaa att ata aag acc     6720
 His Pro Lys Arg Ala Val Phe Arg His Asn Leu Glu Ile Ile Lys Thr
2225                2230                2235                2240

 ctt gtc gag tgc tgg aag gat tgt tta tcc atc cct tat agg tta ata     6768
 Leu Val Glu Cys Trp Lys Asp Cys Leu Ser Ile Pro Tyr Arg Leu Ile
                2245                2250                2255

 ttt gaa aag ttt tcc ggt aaa gat cct aat tct aaa gac aac tca gta     6816
 Phe Glu Lys Phe Ser Gly Lys Asp Pro Asn Ser Lys Asp Asn Ser Val
            2260                2265                2270

 ggg att caa ttg cta ggc atc gtg atg gcc aat gac ctg cct ccc tat     6864
 Gly Ile Gln Leu Leu Gly Ile Val Met Ala Asn Asp Leu Pro Pro Tyr
        2275                2280                2285

 gac cca cag tgt ggc atc cag agt agc gaa tac ttc cag gct ttg gtg     6912
 Asp Pro Gln Cys Gly Ile Gln Ser Ser Glu Tyr Phe Gln Ala Leu Val
    2290                2295                2300

 aat aat atg tcc ttt gta aga tat aaa gaa gtg tat gcc gct gca gca     6960
 Asn Asn Met Ser Phe Val Arg Tyr Lys Glu Val Tyr Ala Ala Ala Ala
2305                2310                2315                2320

 gaa gtt cta gga ctt ata ctt cga tat gtt atg gag aga aaa aac ata     7008
 Glu Val Leu Gly Leu Ile Leu Arg Tyr Val Met Glu Arg Lys Asn Ile
                2325                2330                2335

 ctg gag gag tct ctg tgt gaa ctg gtt gcg aaa caa ttg aag caa cat     7056
 Leu Glu Glu Ser Leu Cys Glu Leu Val Ala Lys Gln Leu Lys Gln His
            2340                2345                2350

 cag aat act atg gag gac aag ttt att gtg tgc ttg aac aaa gtg acc     7104
 Gln Asn Thr Met Glu Asp Lys Phe Ile Val Cys Leu Asn Lys Val Thr
        2355                2360                2365

 aag agc ttc cct cct ctt gca gac agg ttc atg aat gct gtg ttc ttt     7152
 Lys Ser Phe Pro Pro Leu Ala Asp Arg Phe Met Asn Ala Val Phe Phe
    2370                2375                2380

 ctg ctg cca aaa ttt cat gga gtg ttg aaa aca ctc tgt ctg gag gtg     7200
 Leu Leu Pro Lys Phe His Gly Val Leu Lys Thr Leu Cys Leu Glu Val
2385                2390                2395                2400

 gta ctt tgt cgt gtg gag gga atg aca gag ctg tac ttc cag tta aag     7248
 Val Leu Cys Arg Val Glu Gly Met Thr Glu Leu Tyr Phe Gln Leu Lys
                2405                2410                2415

 agc aag gac ttc gtt caa gtc atg aga cat aga gat gat gaa aga caa     7296
 Ser Lys Asp Phe Val Gln Val Met Arg His Arg Asp Asp Glu Arg Gln
            2420                2425                2430

 aaa gta tgt ttg gac ata att tat aag atg atg cca aag tta aaa cca     7344
 Lys Val Cys Leu Asp Ile Ile Tyr Lys Met Met Pro Lys Leu Lys Pro
        2435                2440                2445

 gta gaa ctc cga gaa ctt ctg aac ccc gtt gtg gaa ttc gtt tcc cat     7392
 Val Glu Leu Arg Glu Leu Leu Asn Pro Val Val Glu Phe Val Ser His
    2450                2455                2460

 cct tct aca aca tgt agg gaa caa atg tat aat att ctc atg tgg att     7440
 Pro Ser Thr Thr Cys Arg Glu Gln Met Tyr Asn Ile Leu Met Trp Ile
2465                2470                2475                2480

 cat gat aat tac aga gat cca gaa agt gag aca gat aat gac tcc cag     7488
 His Asp Asn Tyr Arg Asp Pro Glu Ser Glu Thr Asp Asn Asp Ser Gln
                2485                2490                2495

 gaa ata ttt aag ttg gca aaa gat gtg ctg att caa gga ttg atc gat     7536
 Glu Ile Phe Lys Leu Ala Lys Asp Val Leu Ile Gln Gly Leu Ile Asp
            2500                2505                2510

 gag aac cct gga ctt caa tta att att cga aat ttc tgg agc cat gaa     7584
 Glu Asn Pro Gly Leu Gln Leu Ile Ile Arg Asn Phe Trp Ser His Glu
        2515                2520                2525

 act agg tta cct tca aat acc ttg gac cgg ttg ctg gca cta aat tcc     7632
 Thr Arg Leu Pro Ser Asn Thr Leu Asp Arg Leu Leu Ala Leu Asn Ser
    2530                2535                2540

 tta tat tct cct aag ata gaa gtg cac ttt tta agt tta gca aca aat     7680
 Leu Tyr Ser Pro Lys Ile Glu Val His Phe Leu Ser Leu Ala Thr Asn
2545                2550                2555                2560

 ttt ctg ctc gaa atg acc agc atg agc cca gat tat cca aac ccc atg     7728
 Phe Leu Leu Glu Met Thr Ser Met Ser Pro Asp Tyr Pro Asn Pro Met
                2565                2570                2575

 ttc gag cat cct ctg tca gaa tgc gaa ttt cag gaa tat acc att gat     7776
 Phe Glu His Pro Leu Ser Glu Cys Glu Phe Gln Glu Tyr Thr Ile Asp
            2580                2585                2590

 tct gat tgg cgt ttc cga agt act gtt ctc act ccg atg ttt gtg gag     7824
 Ser Asp Trp Arg Phe Arg Ser Thr Val Leu Thr Pro Met Phe Val Glu
        2595                2600                2605

 acc cag gcc tcc cag ggc act ctc cag acc cgt acc cag gaa ggg tcc     7872
 Thr Gln Ala Ser Gln Gly Thr Leu Gln Thr Arg Thr Gln Glu Gly Ser
    2610                2615                2620

 ctc tca gct cgc tgg cca gtg gca ggg cag ata agg gcc acc cag cag     7920
 Leu Ser Ala Arg Trp Pro Val Ala Gly Gln Ile Arg Ala Thr Gln Gln
2625                2630                2635                2640

 cag cat gac ttc aca ctg aca cag act gca gat gga aga agc tca ttt     7968
 Gln His Asp Phe Thr Leu Thr Gln Thr Ala Asp Gly Arg Ser Ser Phe
                2645                2650                2655

 gat tgg ctg acc ggg agc agc act gac ccg ctg gtc gac cac acc agt     8016
 Asp Trp Leu Thr Gly Ser Ser Thr Asp Pro Leu Val Asp His Thr Ser
            2660                2665                2670

 ccc tca tct gac tcc ttg ctg ttt gcc cac aag agg agt gaa agg tta     8064
 Pro Ser Ser Asp Ser Leu Leu Phe Ala His Lys Arg Ser Glu Arg Leu
        2675                2680                2685

 cag aga gca ccc ttg aag tca gtg ggg cct gat ttt ggg aaa aaa agg     8112
 Gln Arg Ala Pro Leu Lys Ser Val Gly Pro Asp Phe Gly Lys Lys Arg
    2690                2695                2700

 ctg ggc ctt cca ggg gac gag gtg gat aac aaa gtg aaa ggt gcg gcc     8160
 Leu Gly Leu Pro Gly Asp Glu Val Asp Asn Lys Val Lys Gly Ala Ala
2705                2710                2715                2720

 ggc cgg acg gac cta cta cga ctg cgc aga cgg ttt atg agg gac cag     8208
 Gly Arg Thr Asp Leu Leu Arg Leu Arg Arg Arg Phe Met Arg Asp Gln
                2725                2730                2735

 gag aag ctc agt ttg atg tat gcc aga aaa ggc gtt gct gag caa aaa     8256
 Glu Lys Leu Ser Leu Met Tyr Ala Arg Lys Gly Val Ala Glu Gln Lys
            2740                2745                2750

 cga gag aag gaa atc aag agt gag tta aaa atg aag cag gat gcc cag     8304
 Arg Glu Lys Glu Ile Lys Ser Glu Leu Lys Met Lys Gln Asp Ala Gln
        2755                2760                2765

 gtc gtt ctg tac aga agc tac cgg cac gga gac ctt cct gac att cag     8352
 Val Val Leu Tyr Arg Ser Tyr Arg His Gly Asp Leu Pro Asp Ile Gln
    2770                2775                2780

 atc aag cac agc agc ctc atc acc ccg tta cag gcc gtg gcc cag agg     8400
 Ile Lys His Ser Ser Leu Ile Thr Pro Leu Gln Ala Val Ala Gln Arg
2785                2790                2795                2800

 gac cca ata att gca aaa cag ctc ttt agc agc ttg ttt tct gga att     8448
 Asp Pro Ile Ile Ala Lys Gln Leu Phe Ser Ser Leu Phe Ser Gly Ile
                2805                2810                2815

 ttg aaa gag atg gat aaa ttt aag aca ctg tct gaa aaa aac aac atc     8496
 Leu Lys Glu Met Asp Lys Phe Lys Thr Leu Ser Glu Lys Asn Asn Ile
            2820                2825                2830

 act caa aag ttg ctt caa gac ttc aat cgt ttt ctt aat acc acc ttc     8544
 Thr Gln Lys Leu Leu Gln Asp Phe Asn Arg Phe Leu Asn Thr Thr Phe
        2835                2840                2845

 tct ttc ttt cca ccc ttt gtc tct tgt att cag gac att agc tgt cag     8592
 Ser Phe Phe Pro Pro Phe Val Ser Cys Ile Gln Asp Ile Ser Cys Gln
    2850                2855                2860

 cac gca gcc ctg ctg agc ctc gac cca gcg gct gtt agc gct ggt tgc     8640
 His Ala Ala Leu Leu Ser Leu Asp Pro Ala Ala Val Ser Ala Gly Cys
2865                2870                2875                2880

 ctg gcc agc cta cag cag ccc gtg ggc atc cgc ctg cta gag gag gct     8688
 Leu Ala Ser Leu Gln Gln Pro Val Gly Ile Arg Leu Leu Glu Glu Ala
                2885                2890                2895

 ctg ctc cgc ctg ctg cct gct gag ctg cct gcc aag cga gtc cgt ggg     8736
 Leu Leu Arg Leu Leu Pro Ala Glu Leu Pro Ala Lys Arg Val Arg Gly
            2900                2905                2910

 aag gcc cgc ctc cct cct gat gtc ctc aga tgg gtg gag ctt gct aag     8784
 Lys Ala Arg Leu Pro Pro Asp Val Leu Arg Trp Val Glu Leu Ala Lys
        2915                2920                2925

 ctg tat aga tca att gga gaa tac gac gtc ctc cgt ggg att ttt acc     8832
 Leu Tyr Arg Ser Ile Gly Glu Tyr Asp Val Leu Arg Gly Ile Phe Thr
    2930                2935                2940

 agt gag ata gga aca aag caa atc act cag agt gca tta tta gca gaa     8880
 Ser Glu Ile Gly Thr Lys Gln Ile Thr Gln Ser Ala Leu Leu Ala Glu
2945                2950                2955                2960

 gcc aga agt gat tat tct gaa gct gct aag cag tat gat gag gct ctc     8928
 Ala Arg Ser Asp Tyr Ser Glu Ala Ala Lys Gln Tyr Asp Glu Ala Leu
                2965                2970                2975

 aat aaa caa gac tgg gta gat ggt gag ccc aca gaa gcc gag aag gat     8976
 Asn Lys Gln Asp Trp Val Asp Gly Glu Pro Thr Glu Ala Glu Lys Asp
            2980                2985                2990

 ttt tgg gaa ctt gca tcc ctt gac tgt tac aac cac ctt gct gag tgg     9024
 Phe Trp Glu Leu Ala Ser Leu Asp Cys Tyr Asn His Leu Ala Glu Trp
        2995                3000                3005

 aaa tca ctt gaa tac tgt tct aca gcc agt ata gac agt gag aac ccc     9072
 Lys Ser Leu Glu Tyr Cys Ser Thr Ala Ser Ile Asp Ser Glu Asn Pro
    3010                3015                3020

 cca gac cta aat aaa atc tgg agt gaa cca ttt tat cag gaa aca tat     9120
 Pro Asp Leu Asn Lys Ile Trp Ser Glu Pro Phe Tyr Gln Glu Thr Tyr
3025                3030                3035                3040

 cta cct tac atg atc cgc agc aag ctg aag ctg ctg ctc cag gga gag     9168
 Leu Pro Tyr Met Ile Arg Ser Lys Leu Lys Leu Leu Leu Gln Gly Glu
                3045                3050                3055

 gct gac cag tcc ctg ctg aca ttt att gac aaa gct atg cac ggg gag     9216
 Ala Asp Gln Ser Leu Leu Thr Phe Ile Asp Lys Ala Met His Gly Glu
            3060                3065                3070

 ctc cag aag gcg att cta gag ctt cat tac agt caa gag ctg agt ctg     9264
 Leu Gln Lys Ala Ile Leu Glu Leu His Tyr Ser Gln Glu Leu Ser Leu
        3075                3080                3085

 ctt tac ctc ctg caa gat gat gtt gac aga gcc aaa tat tac att caa     9312
 Leu Tyr Leu Leu Gln Asp Asp Val Asp Arg Ala Lys Tyr Tyr Ile Gln
    3090                3095                3100

 aat ggc att cag agt ttt atg cag aat tat tct agt att gat gtc ctc     9360
 Asn Gly Ile Gln Ser Phe Met Gln Asn Tyr Ser Ser Ile Asp Val Leu
3105                3110                3115                3120

 tta cac caa agt aga ctc acc aaa ttg cag tct gta cag gct tta aca     9408
 Leu His Gln Ser Arg Leu Thr Lys Leu Gln Ser Val Gln Ala Leu Thr
                3125                3130                3135

 gaa att cag gag ttc atc agc ttt ata agc aaa caa ggc aat tta tca     9456
 Glu Ile Gln Glu Phe Ile Ser Phe Ile Ser Lys Gln Gly Asn Leu Ser
            3140                3145                3150

 tct caa gtt ccc ctt aag aga ctt ctg aac acc tgg aca aac aga tat     9504
 Ser Gln Val Pro Leu Lys Arg Leu Leu Asn Thr Trp Thr Asn Arg Tyr
        3155                3160                3165

 cca gat gct aaa atg gac cca atg aac atc tgg gat gac atc atc aca     9552
 Pro Asp Ala Lys Met Asp Pro Met Asn Ile Trp Asp Asp Ile Ile Thr
    3170                3175                3180

 aat cga tgt ttc ttt ctc agc aaa ata gag gag aag ctt acc cct ctt     9600
 Asn Arg Cys Phe Phe Leu Ser Lys Ile Glu Glu Lys Leu Thr Pro Leu
3185                3190                3195                3200

 cca gaa gat aat agt atg aat gtg gat caa gat gga gac ccc agt gac     9648
 Pro Glu Asp Asn Ser Met Asn Val Asp Gln Asp Gly Asp Pro Ser Asp
                3205                3210                3215

 agg atg gaa gtg caa gag cag gaa gaa gat atc agc tcc ctg atc agg     9696
 Arg Met Glu Val Gln Glu Gln Glu Glu Asp Ile Ser Ser Leu Ile Arg
            3220                3225                3230

 agt tgc aag ttt tcc atg aaa atg aag atg ata gac agt gcc cgg aag     9744
 Ser Cys Lys Phe Ser Met Lys Met Lys Met Ile Asp Ser Ala Arg Lys
        3235                3240                3245

 cag aac aat ttc tca ctt gct atg aaa cta ctg aag gag ctg cat aaa     9792
 Gln Asn Asn Phe Ser Leu Ala Met Lys Leu Leu Lys Glu Leu His Lys
    3250                3255                3260

 gag tca aaa acc aga gac gat tgg ctg gtg agc tgg gtg cag agc tac     9840
 Glu Ser Lys Thr Arg Asp Asp Trp Leu Val Ser Trp Val Gln Ser Tyr
3265                3270                3275                3280

 tgc cgc ctg agc cac tgc cgg agc cgg tcc cag ggc tgc tct gag cag     9888
 Cys Arg Leu Ser His Cys Arg Ser Arg Ser Gln Gly Cys Ser Glu Gln
                3285                3290                3295

 gtg ctc act gtg ctg aaa aca gtc tct ttg ttg gat gag aac aac gtg     9936
 Val Leu Thr Val Leu Lys Thr Val Ser Leu Leu Asp Glu Asn Asn Val
            3300                3305                3310

 tca agc tac tta agc aaa aat att ctg gct ttc cgt gac cag aac att     9984
 Ser Ser Tyr Leu Ser Lys Asn Ile Leu Ala Phe Arg Asp Gln Asn Ile
        3315                3320                3325

 ctc ttg ggt aca act tac agg atc ata gcg aat gct ctc agc agt gag    10032
 Leu Leu Gly Thr Thr Tyr Arg Ile Ile Ala Asn Ala Leu Ser Ser Glu
    3330                3335                3340

 cca gcc tgc ctt gct gaa atc gag gag gac aag gct aga aga atc tta    10080
 Pro Ala Cys Leu Ala Glu Ile Glu Glu Asp Lys Ala Arg Arg Ile Leu
3345                3350                3355                3360

 gag ctt tct gga tcc agt tca gag gat tca gag aag gtg atc gcg ggt    10128
 Glu Leu Ser Gly Ser Ser Ser Glu Asp Ser Glu Lys Val Ile Ala Gly
                3365                3370                3375

 ctg tac cag aga gca ttc cag cac ctc tct gag gct gtg cag gcg gct    10176
 Leu Tyr Gln Arg Ala Phe Gln His Leu Ser Glu Ala Val Gln Ala Ala
            3380                3385                3390

 gag gag gag gcc cag cct ccc tcc tgg agc tgt ggg cct gca gct ggg    10224
 Glu Glu Glu Ala Gln Pro Pro Ser Trp Ser Cys Gly Pro Ala Ala Gly
        3395                3400                3405

 gtg att gat gct tac atg acg ctg gca gat ttc tgt gac caa cag ctg    10272
 Val Ile Asp Ala Tyr Met Thr Leu Ala Asp Phe Cys Asp Gln Gln Leu
    3410                3415                3420

 cgc aag gag gaa gag aat gca tca gtt att gat tct gca gaa ctg cag    10320
 Arg Lys Glu Glu Glu Asn Ala Ser Val Ile Asp Ser Ala Glu Leu Gln
3425                3430                3435                3440

 gcg tat cca gca ctt gtg gtg gag aaa atg ttg aaa gct tta aaa tta    10368
 Ala Tyr Pro Ala Leu Val Val Glu Lys Met Leu Lys Ala Leu Lys Leu
                3445                3450                3455

 aat tcc aat gaa gcc aga ttg aag ttt cct aga tta ctt cag att ata    10416
 Asn Ser Asn Glu Ala Arg Leu Lys Phe Pro Arg Leu Leu Gln Ile Ile
            3460                3465                3470

 gaa cgg tat cca gag gag act ttg agc ctc atg aca aaa gag atc tct    10464
 Glu Arg Tyr Pro Glu Glu Thr Leu Ser Leu Met Thr Lys Glu Ile Ser
        3475                3480                3485

 tcc gtt ccc tgc tgg cag ttc atc agc tgg atc agc cac atg gtg gcc    10512
 Ser Val Pro Cys Trp Gln Phe Ile Ser Trp Ile Ser His Met Val Ala
    3490                3495                3500

 tta ctg gac aaa gac caa gcc gtt gct gtt cag cac tct gtg gaa gaa    10560
 Leu Leu Asp Lys Asp Gln Ala Val Ala Val Gln His Ser Val Glu Glu
3505                3510                3515                3520

 atc act gat aac tac ccg cag gct att gtt tat ccc ttc atc ata agc    10608
 Ile Thr Asp Asn Tyr Pro Gln Ala Ile Val Tyr Pro Phe Ile Ile Ser
                3525                3530                3535

 agc gaa agc tat tcc ttc aag gat act tct act ggt cat aag aat aag    10656
 Ser Glu Ser Tyr Ser Phe Lys Asp Thr Ser Thr Gly His Lys Asn Lys
            3540                3545                3550

 gag ttt gtg gca agg att aaa agt aag ttg gat caa gga gga gtg att    10704
 Glu Phe Val Ala Arg Ile Lys Ser Lys Leu Asp Gln Gly Gly Val Ile
        3555                3560                3565

 caa gat ttt att aat gcc tta gat cag ctc tct aat cct gaa ctg ctc    10752
 Gln Asp Phe Ile Asn Ala Leu Asp Gln Leu Ser Asn Pro Glu Leu Leu
    3570                3575                3580

 ttt aag gat tgg agc aat gat gta aga gct gaa cta gca aaa acc cct    10800
 Phe Lys Asp Trp Ser Asn Asp Val Arg Ala Glu Leu Ala Lys Thr Pro
3585                3590                3595                3600

 gta aat aaa aaa aac att gaa aaa atg tat gaa aga atg tat gca gcc    10848
 Val Asn Lys Lys Asn Ile Glu Lys Met Tyr Glu Arg Met Tyr Ala Ala
                3605                3610                3615

 ttg ggt gac cca aag gct cca ggc ctg ggg gcc ttt aga agg aag ttt    10896
 Leu Gly Asp Pro Lys Ala Pro Gly Leu Gly Ala Phe Arg Arg Lys Phe
            3620                3625                3630

 att cag act ttt gga aaa gaa ttt gat aaa cat ttt ggg aaa gga ggt    10944
 Ile Gln Thr Phe Gly Lys Glu Phe Asp Lys His Phe Gly Lys Gly Gly
        3635                3640                3645

 tct aaa cta ctg aga atg aag ctc agt gac ttc aac gac att acc aac    10992
 Ser Lys Leu Leu Arg Met Lys Leu Ser Asp Phe Asn Asp Ile Thr Asn
    3650                3655                3660

 atg cta ctt tta aaa atg aac aaa gac tca aag ccc cct ggg aat ctg    11040
 Met Leu Leu Leu Lys Met Asn Lys Asp Ser Lys Pro Pro Gly Asn Leu
3665                3670                3675                3680

 aaa gaa tgt tca ccc tgg atg agc gac ttc aaa gtg gag ttc ctg aga    11088
 Lys Glu Cys Ser Pro Trp Met Ser Asp Phe Lys Val Glu Phe Leu Arg
                3685                3690                3695

 aat gag ctg gag att ccc ggt cag tat gac ggt agg gga aag cca ttg    11136
 Asn Glu Leu Glu Ile Pro Gly Gln Tyr Asp Gly Arg Gly Lys Pro Leu
            3700                3705                3710

 cca gag tac cac gtg cga atc gcc ggg ttt gat gag cgg gtg aca gtc    11184
 Pro Glu Tyr His Val Arg Ile Ala Gly Phe Asp Glu Arg Val Thr Val
        3715                3720                3725

 atg gcg tct ctg cga agg ccc aag cgc atc atc atc cgt ggc cat gac    11232
 Met Ala Ser Leu Arg Arg Pro Lys Arg Ile Ile Ile Arg Gly His Asp
    3730                3735                3740

 gag agg gaa cac cct ttc ctg gtg aag ggt ggc gag gac ctg cgg cag    11280
 Glu Arg Glu His Pro Phe Leu Val Lys Gly Gly Glu Asp Leu Arg Gln
3745                3750                3755                3760

 gac cag cgc gtg gag cag ctc ttc cag gtc atg aat ggg atc ctg gcc    11328
 Asp Gln Arg Val Glu Gln Leu Phe Gln Val Met Asn Gly Ile Leu Ala
                3765                3770                3775

 caa gac tcc gcc tgc agc cag agg gcc ctg cag ctg agg acc tat agc    11376
 Gln Asp Ser Ala Cys Ser Gln Arg Ala Leu Gln Leu Arg Thr Tyr Ser
            3780                3785                3790

 gtt gtg ccc atg acc tcc agt gat ccc agg gca ccg ccg tgt gaa tat    11424
 Val Val Pro Met Thr Ser Ser Asp Pro Arg Ala Pro Pro Cys Glu Tyr
        3795                3800                3805

 aaa gat tgg ctg aca aaa atg tca gga aaa cat gat gtt gga gct tac    11472
 Lys Asp Trp Leu Thr Lys Met Ser Gly Lys His Asp Val Gly Ala Tyr
    3810                3815                3820

 atg cta atg tat aag ggc gct aat cgt act gaa aca gtc acg tct ttt    11520
 Met Leu Met Tyr Lys Gly Ala Asn Arg Thr Glu Thr Val Thr Ser Phe
3825                3830                3835                3840

 aga aaa cga gaa agt aaa gtg cct gct gat ctc tta aag cgg gcc ttc    11568
 Arg Lys Arg Glu Ser Lys Val Pro Ala Asp Leu Leu Lys Arg Ala Phe
                3845                3850                3855

 gtg agg atg agt aca agc cct gag gct ttc ctg gcg ctc cgc tcc cac    11616
 Val Arg Met Ser Thr Ser Pro Glu Ala Phe Leu Ala Leu Arg Ser His
            3860                3865                3870

 ttc gcc agc tct cac gct ctg ata tgc atc agc cac tgg atc ctc ggg    11664
 Phe Ala Ser Ser His Ala Leu Ile Cys Ile Ser His Trp Ile Leu Gly
        3875                3880                3885

 att gga gac aga cat ctg aac aac ttt atg gtg gcc atg gag act ggc    11712
 Ile Gly Asp Arg His Leu Asn Asn Phe Met Val Ala Met Glu Thr Gly
    3890                3895                3900

 ggc gtg atc ggg atc gac ttt ggg cat gcg ttt gga tcc gct aca cag    11760
 Gly Val Ile Gly Ile Asp Phe Gly His Ala Phe Gly Ser Ala Thr Gln
3905                3910                3915                3920

 ttt ctg cca gtc cct gag ttg atg cct ttt cgg cta act cgc cag ttt    11808
 Phe Leu Pro Val Pro Glu Leu Met Pro Phe Arg Leu Thr Arg Gln Phe
                3925                3930                3935

 atc aat ctg atg tta cca atg aaa gaa acg ggc ctt atg tac agc atc    11856
 Ile Asn Leu Met Leu Pro Met Lys Glu Thr Gly Leu Met Tyr Ser Ile
            3940                3945                3950

 atg gta cac gca ctc cgg gcc ttc cgc tca gac cct ggc ctg ctc acc    11904
 Met Val His Ala Leu Arg Ala Phe Arg Ser Asp Pro Gly Leu Leu Thr
        3955                3960                3965

 aac acc atg gat gtg ttt gtc aag gag ccc tcc ttt gat tgg aaa aat    11952
 Asn Thr Met Asp Val Phe Val Lys Glu Pro Ser Phe Asp Trp Lys Asn
    3970                3975                3980

 ttt gaa cag aaa atg ctg aaa aaa gga ggg tca tgg att caa gaa ata    12000
 Phe Glu Gln Lys Met Leu Lys Lys Gly Gly Ser Trp Ile Gln Glu Ile
3985                3990                3995                4000

 aat gtt gct gaa aaa aat tgg tac ccc cga cag aaa ata tgt tac gct    12048
 Asn Val Ala Glu Lys Asn Trp Tyr Pro Arg Gln Lys Ile Cys Tyr Ala
                4005                4010                4015

 aag aga aag tta gca ggt gcc aat cca gca gtc att act tgt gat gag    12096
 Lys Arg Lys Leu Ala Gly Ala Asn Pro Ala Val Ile Thr Cys Asp Glu
            4020                4025                4030

 cta ctc ctg ggt cat gag aag gcc cct gcc ttc aga gac tat gtg gct    12144
 Leu Leu Leu Gly His Glu Lys Ala Pro Ala Phe Arg Asp Tyr Val Ala
        4035                4040                4045

 gtg gca cga gga agc aaa gat cac aac att cgt gcc caa gaa cca gag    12192
 Val Ala Arg Gly Ser Lys Asp His Asn Ile Arg Ala Gln Glu Pro Glu
    4050                4055                4060

 agt ggg ctt tca gaa gag act caa gtg aag tgc ctg atg gac cag gca    12240
 Ser Gly Leu Ser Glu Glu Thr Gln Val Lys Cys Leu Met Asp Gln Ala
4065                4070                4075                4080

 aca gac ccc aac atc ctt ggc aga acc tgg gaa gga tgg gag ccc tgg    12288
 Thr Asp Pro Asn Ile Leu Gly Arg Thr Trp Glu Gly Trp Glu Pro Trp
                4085                4090                4095

 atg tga ggtctgtggg agtctgcaga tagaaagcat tacattgttt aaagaatcta     12344
 Met 


 ctatactttg gttggcagca ttccatgagc tgattttcct gaaacactaa agagaaatgt  12404

 cttttgtgct acagtttcgt agcatgagtt taaatcaaga ttatgatgag taaatgtgta  12464

 tgggttaaat caaagataag gttatagtaa catcaaagat taggtgaggt ttatagaaag  12524

 atagatatcc aggcttacca aagtattaag tcaagaatat aatatgtgat cagctttcaa  12584

 agcatttaca agtgctgcaa gttagtgaaa cagctgtctc cgtaaatgga ggaaatgtgg  12644

 ggaagccttg gaatgccctt ctggttctgg cacattggaa agcacactca gaaggcttca  12704

 tcaccaagat tttgggagag taaagctaag tatagttgat gtaacattgt agaagcagca  12764

 taggaacaat aagaacaata ggtaaagcta taattatggc ttatatttag aaatgactgc  12824

 atttgatatt ttaggatatt tttctaggtt ttttcctttc attttattct cttctagttt  12884

 tgacatttta tgatagattt gctctctaga aggaaacgtc tttatttagg agggcaaaaa  12944

 ttttggtcat agcattcact tttgctattc caatctacaa ctggaagata cataaaagtg  13004

 ctttgcattg aatttgggat aacttcaaaa atcccatggt tgttgttagg gatagtacta  13064

 agcatttcag ttccaggaga ataaaagaaa ttcctatttg aaatgaattc ctcatttgga  13124

 ggaaaaaaag catgcattct agcacaacaa gatgaaatta tggaatacaa aagtggctcc  13184

 ttcccatgtg cagtccctgt ccccccccgc cagtcctcca cacccaaact gtttctgatt  13244

 ggcttttagc tttttgttgt tttttttttt ccttctaaca cttgtatttg gaggctcttc  13304

 tgtgattttg agaagtatac tcttgagtgt ttaataaagt ttttttccaa aagtaaaaaa  13364

 aaaaaaaaaa a                                                       13375




      <210> 171
      <211> 13468
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(12387)

      <400> 171
  atg gcg ggc tcc gga gcc ggt gtg cgt tgc tcc ctg ctg cgg ctg cag      48
  Met Ala Gly Ser Gly Ala Gly Val Arg Cys Ser Leu Leu Arg Leu Gln
    1               5                  10                  15

 gag acc ttg tcc gct gcg gac cgc tgc ggt gct gcc ctg gcc ggt cat       96
 Glu Thr Leu Ser Ala Ala Asp Arg Cys Gly Ala Ala Leu Ala Gly His
              20                  25                  30

 caa ctg atc cgc ggc ctg ggg cag gaa tgc gtc ctg agc agc agc ccc      144
 Gln Leu Ile Arg Gly Leu Gly Gln Glu Cys Val Leu Ser Ser Ser Pro
          35                  40                  45

 gcg gtg ctg gca tta cag aca tct tta gtt ttt tcc aga gat ttc ggt      192
 Ala Val Leu Ala Leu Gln Thr Ser Leu Val Phe Ser Arg Asp Phe Gly
      50                  55                  60

 ttg ctt gta ttt gtc cgg aag tca ctc aac agt att gaa ttt cgt gaa      240
 Leu Leu Val Phe Val Arg Lys Ser Leu Asn Ser Ile Glu Phe Arg Glu
  65                  70                  75                  80

 tgt aga gaa gaa atc cta aag ttt tta tgt att ttc tta gaa aaa atg      288
 Cys Arg Glu Glu Ile Leu Lys Phe Leu Cys Ile Phe Leu Glu Lys Met
                  85                  90                  95

 ggc cag aag atc gca cct tac tct gtt gaa att aag aac act tgt acc      336
 Gly Gln Lys Ile Ala Pro Tyr Ser Val Glu Ile Lys Asn Thr Cys Thr
             100                 105                 110

 agt gtt tat aca aaa gat aga gct gct aaa tgt aaa att cca gcc ctg      384
 Ser Val Tyr Thr Lys Asp Arg Ala Ala Lys Cys Lys Ile Pro Ala Leu
         115                 120                 125

 gac ctt ctt att aag tta ctt cag act ttt aga agt tct aga ctc atg      432
 Asp Leu Leu Ile Lys Leu Leu Gln Thr Phe Arg Ser Ser Arg Leu Met
     130                 135                 140

 gat gaa ttt aaa att gga gaa tta ttt agt aaa ttc tat gga gaa ctt      480
 Asp Glu Phe Lys Ile Gly Glu Leu Phe Ser Lys Phe Tyr Gly Glu Leu
 145                 150                 155                 160

 gca ttg aaa aaa aaa ata cca gat aca gtt tta gaa aaa gta tat gag      528
 Ala Leu Lys Lys Lys Ile Pro Asp Thr Val Leu Glu Lys Val Tyr Glu
                 165                 170                 175

 ctc cta gga tta ttg ggt gaa gtt cat cct agt gag atg ata aat aat      576
 Leu Leu Gly Leu Leu Gly Glu Val His Pro Ser Glu Met Ile Asn Asn
             180                 185                 190

 gca gaa aac ctg ttc cgc gct ttt ctg ggt gaa ctt aag acc cag atg      624
 Ala Glu Asn Leu Phe Arg Ala Phe Leu Gly Glu Leu Lys Thr Gln Met
         195                 200                 205

 aca tca gca gta aga gag ccc aaa cta cct gtt ctg gca gga tgt ctg      672
 Thr Ser Ala Val Arg Glu Pro Lys Leu Pro Val Leu Ala Gly Cys Leu
     210                 215                 220

 aag ggg ttg tcc tca ctt ctg tgc aac ttc act aag tcc atg gaa gaa      720
 Lys Gly Leu Ser Ser Leu Leu Cys Asn Phe Thr Lys Ser Met Glu Glu
 225                 230                 235                 240

 gat ccc cag act tca agg gag att ttt aat ttt gta cta aag gca att      768
 Asp Pro Gln Thr Ser Arg Glu Ile Phe Asn Phe Val Leu Lys Ala Ile
                 245                 250                 255

 cgt cct cag att gat ctg aag aga tat gct gtg ccc tca gct ggc ttg      816
 Arg Pro Gln Ile Asp Leu Lys Arg Tyr Ala Val Pro Ser Ala Gly Leu
             260                 265                 270

 cgc cta ttt gcc ctg cat gca tct cag ttt agc acc tgc ctt ctg gac      864
 Arg Leu Phe Ala Leu His Ala Ser Gln Phe Ser Thr Cys Leu Leu Asp
         275                 280                 285

 aac tac gtg tct cta ttt gaa gtc ttg tta aag tgg tgt gcc cac aca      912
 Asn Tyr Val Ser Leu Phe Glu Val Leu Leu Lys Trp Cys Ala His Thr
     290                 295                 300

 aat gta gaa ttg aaa aaa gct gca ctt tca gcc ctg gaa tcc ttt ctg      960
 Asn Val Glu Leu Lys Lys Ala Ala Leu Ser Ala Leu Glu Ser Phe Leu
 305                 310                 315                 320

 aaa cag gtt tct aat atg gtg gcg aaa aat gca gaa atg cat aaa aat     1008
 Lys Gln Val Ser Asn Met Val Ala Lys Asn Ala Glu Met His Lys Asn
                 325                 330                 335

 aaa ctg cag tac ttt atg gag cag ttt tat gga atc atc aga aat gtg     1056
 Lys Leu Gln Tyr Phe Met Glu Gln Phe Tyr Gly Ile Ile Arg Asn Val
             340                 345                 350

 gat tcg aac aac aag gag tta tct att gct atc cgt gga tat gga ctt     1104
 Asp Ser Asn Asn Lys Glu Leu Ser Ile Ala Ile Arg Gly Tyr Gly Leu
         355                 360                 365

 ttt gca gga ccg tgc aag gtt ata aac gca aaa gat gtt gac ttc atg     1152
 Phe Ala Gly Pro Cys Lys Val Ile Asn Ala Lys Asp Val Asp Phe Met
     370                 375                 380

 tac gtt gag ctc att cag cgc tgc aag cag atg ttc ctc acc cag aca     1200
 Tyr Val Glu Leu Ile Gln Arg Cys Lys Gln Met Phe Leu Thr Gln Thr
 385                 390                 395                 400

 gac act ggt gac tac cgt gtt tat cag atg cca agc ttc ctc cag tct     1248
 Asp Thr Gly Asp Tyr Arg Val Tyr Gln Met Pro Ser Phe Leu Gln Ser
                 405                 410                 415

 gtt gca agc gtc ttg ctg tac ctt gac aca gtt cct gag gtg tat act     1296
 Val Ala Ser Val Leu Leu Tyr Leu Asp Thr Val Pro Glu Val Tyr Thr
             420                 425                 430

 cca gtt ctg gag cac ctc gtg gtg atg cag ata gac agt ttc cca cag     1344
 Pro Val Leu Glu His Leu Val Val Met Gln Ile Asp Ser Phe Pro Gln
         435                 440                 445

 tac agt cca aaa atg cag ctg gtg tgt tgc aga gcc ata gtg aag gtg     1392
 Tyr Ser Pro Lys Met Gln Leu Val Cys Cys Arg Ala Ile Val Lys Val
     450                 455                 460

 ttc cta gct ttg gca gca aaa ggg cca gtt ctc agg aat tgc att agt     1440
 Phe Leu Ala Leu Ala Ala Lys Gly Pro Val Leu Arg Asn Cys Ile Ser
 465                 470                 475                 480

 act gtg gtg cat cag ggt tta atc aga ata tgt tct aaa cca gtg gtc     1488
 Thr Val Val His Gln Gly Leu Ile Arg Ile Cys Ser Lys Pro Val Val
                 485                 490                 495

 ctt cca aag ggc cct gag tct gaa tct gaa gac cac cgt gct tca ggg     1536
 Leu Pro Lys Gly Pro Glu Ser Glu Ser Glu Asp His Arg Ala Ser Gly
             500                 505                 510

 gaa gtc aga act ggc aaa tgg aag gtg ccc aca tac aaa gac tac gtg     1584
 Glu Val Arg Thr Gly Lys Trp Lys Val Pro Thr Tyr Lys Asp Tyr Val
         515                 520                 525

 gat ctc ttc aga cat ctc ctg agc tct gac cag atg atg gat tct att     1632
 Asp Leu Phe Arg His Leu Leu Ser Ser Asp Gln Met Met Asp Ser Ile
     530                 535                 540

 tta gca gat gaa gca ttt ttc tct gtg aat tcc tcc agt gaa agt ctg     1680
 Leu Ala Asp Glu Ala Phe Phe Ser Val Asn Ser Ser Ser Glu Ser Leu
 545                 550                 555                 560

 aat cat tta ctt tat gat gaa ttt gta aaa tcc gtt ttg aag att gtt     1728
 Asn His Leu Leu Tyr Asp Glu Phe Val Lys Ser Val Leu Lys Ile Val
                 565                 570                 575

 gag aaa ttg gat ctt aca ctt gaa ata cag act gtt ggg gaa caa gag     1776
 Glu Lys Leu Asp Leu Thr Leu Glu Ile Gln Thr Val Gly Glu Gln Glu
             580                 585                 590

 aat gga gat gag gcg cct ggt gtt tgg atg atc cca act tca gat cca     1824
 Asn Gly Asp Glu Ala Pro Gly Val Trp Met Ile Pro Thr Ser Asp Pro
         595                 600                 605

 gcg gct aac ttg cat cca gct aaa cct aaa gat ttt tcg gct ttc att     1872
 Ala Ala Asn Leu His Pro Ala Lys Pro Lys Asp Phe Ser Ala Phe Ile
     610                 615                 620

 aac ctg gtg gaa ttt tgc aga gag att ctc cct gag aaa caa gca gaa     1920
 Asn Leu Val Glu Phe Cys Arg Glu Ile Leu Pro Glu Lys Gln Ala Glu
 625                 630                 635                 640

 ttt ttt gaa cca tgg gtg tac tca ttt tca tat gaa tta att ttg caa     1968
 Phe Phe Glu Pro Trp Val Tyr Ser Phe Ser Tyr Glu Leu Ile Leu Gln
                 645                 650                 655

 tct aca agg ttg ccc ctc atc agt ggt ttc tac aaa ttg ctt tct att     2016
 Ser Thr Arg Leu Pro Leu Ile Ser Gly Phe Tyr Lys Leu Leu Ser Ile
             660                 665                 670

 aca gta aga aat gcc aag aaa ata aaa tat ttc gag gga gtt agt cca     2064
 Thr Val Arg Asn Ala Lys Lys Ile Lys Tyr Phe Glu Gly Val Ser Pro
         675                 680                 685

 aag agt ctg aaa cac tct cct gaa gac cca gaa aag tat tct tgc ttt     2112
 Lys Ser Leu Lys His Ser Pro Glu Asp Pro Glu Lys Tyr Ser Cys Phe
     690                 695                 700

 gct tta ttt gtg aaa ttt ggc aaa gag gtg gca gtt aaa atg aag cag     2160
 Ala Leu Phe Val Lys Phe Gly Lys Glu Val Ala Val Lys Met Lys Gln
 705                 710                 715                 720

 tac aaa gat gaa ctt ttg gcc tct tgt ttg acc ttt ctt ctg tcc ttg     2208
 Tyr Lys Asp Glu Leu Leu Ala Ser Cys Leu Thr Phe Leu Leu Ser Leu
                 725                 730                 735

 cca cac aac atc att gaa ctc gat gtt aga gcc tac gtt cct gca ctg     2256
 Pro His Asn Ile Ile Glu Leu Asp Val Arg Ala Tyr Val Pro Ala Leu
             740                 745                 750

 cag atg gct ttc aaa ctg ggc ctg agc tat acc ccc ttg gca gaa gta     2304
 Gln Met Ala Phe Lys Leu Gly Leu Ser Tyr Thr Pro Leu Ala Glu Val
         755                 760                 765

 ggc ctg aat gct cta gaa gaa tgg tca att tat att gac aga cat gta     2352
 Gly Leu Asn Ala Leu Glu Glu Trp Ser Ile Tyr Ile Asp Arg His Val
     770                 775                 780

 atg cag cct tat tac aaa gac att ctc ccc tgc ctg gat gga tac ctg     2400
 Met Gln Pro Tyr Tyr Lys Asp Ile Leu Pro Cys Leu Asp Gly Tyr Leu
 785                 790                 795                 800

 aag act tca gcc ttg tca gat gag acc aag aat aac tgg gaa gtg tca     2448
 Lys Thr Ser Ala Leu Ser Asp Glu Thr Lys Asn Asn Trp Glu Val Ser
                 805                 810                 815

 gct ctt tct cgg gct gcc cag aaa gga ttt aat aaa gtg gtg tta aag     2496
 Ala Leu Ser Arg Ala Ala Gln Lys Gly Phe Asn Lys Val Val Leu Lys
             820                 825                 830

 cat ctg aag aag aca aag aac ctt tca tca aac gaa gca ata tcc tta     2544
 His Leu Lys Lys Thr Lys Asn Leu Ser Ser Asn Glu Ala Ile Ser Leu
         835                 840                 845

 gaa gaa ata aga att aga gta gta caa atg ctt gga tct cta gga gga     2592
 Glu Glu Ile Arg Ile Arg Val Val Gln Met Leu Gly Ser Leu Gly Gly
     850                 855                 860

 caa ata aac aaa aat ctt ctg aca gtc acg tcc tca gat gag atg atg     2640
 Gln Ile Asn Lys Asn Leu Leu Thr Val Thr Ser Ser Asp Glu Met Met
 865                 870                 875                 880

 aag agc tat gtg gcc tgg gac aga gag aag cgg ctg agc ttt gca gtg     2688
 Lys Ser Tyr Val Ala Trp Asp Arg Glu Lys Arg Leu Ser Phe Ala Val
                 885                 890                 895

 ccc ttt aga gag atg aaa cct gtc att ttc ctg gat gtg ttc ctg cct     2736
 Pro Phe Arg Glu Met Lys Pro Val Ile Phe Leu Asp Val Phe Leu Pro
             900                 905                 910

 cga gtc aca gaa tta gcg ctc aca gcc agt gac aga caa act aaa gtt     2784
 Arg Val Thr Glu Leu Ala Leu Thr Ala Ser Asp Arg Gln Thr Lys Val
         915                 920                 925

 gca gcc tgt gaa ctt tta cat agc atg gtt atg ttt atg ttg ggc aaa     2832
 Ala Ala Cys Glu Leu Leu His Ser Met Val Met Phe Met Leu Gly Lys
     930                 935                 940

 gcc acg cag atg cca gaa ggg gga cag gga gcc cca ccc atg tac cag     2880
 Ala Thr Gln Met Pro Glu Gly Gly Gln Gly Ala Pro Pro Met Tyr Gln
 945                 950                 955                 960

 ctc tat aag cgg acg ttt cct gtg ctg ctt cga ctt gcg tgt gat gtt     2928
 Leu Tyr Lys Arg Thr Phe Pro Val Leu Leu Arg Leu Ala Cys Asp Val
                 965                 970                 975

 gat cag gtg aca agg caa ctg tat gag cca cta gtt atg cag ctg att     2976
 Asp Gln Val Thr Arg Gln Leu Tyr Glu Pro Leu Val Met Gln Leu Ile
             980                 985                 990

 cac tgg ttc act aac aac aag aaa ttt gaa agt cag gat act gtt tcc     3024
 His Trp Phe Thr Asn Asn Lys Lys Phe Glu Ser Gln Asp Thr Val Ser
         995                1000                1005

 tta cta gaa gct ata ttg gat gga att gtg gac cct gtt gac agt act     3072
 Leu Leu Glu Ala Ile Leu Asp Gly Ile Val Asp Pro Val Asp Ser Thr
    1010                1015                1020

 tta aga gat ttt tgt ggt cgg tgt att cga gaa ttc ctt aaa tgg tcc     3120
 Leu Arg Asp Phe Cys Gly Arg Cys Ile Arg Glu Phe Leu Lys Trp Ser
1025                1030                1035                1040

 att aag caa ata aca cca cag cag cag gag aag agt cca gta aac acc     3168
 Ile Lys Gln Ile Thr Pro Gln Gln Gln Glu Lys Ser Pro Val Asn Thr
                1045                1050                1055

 aaa tcg ctt ttc aag cga ctt tat agc ctt gcg ctt cac ccc aat gct     3216
 Lys Ser Leu Phe Lys Arg Leu Tyr Ser Leu Ala Leu His Pro Asn Ala
            1060                1065                1070

 ttc aag agg ctg gga gca tca ctt gcc ttt aat aat atc tac agg gaa     3264
 Phe Lys Arg Leu Gly Ala Ser Leu Ala Phe Asn Asn Ile Tyr Arg Glu
        1075                1080                1085

 ttc agg gaa gaa gag tct ctg gtg gaa cag ttt gtg ttt gaa gcc ttg     3312
 Phe Arg Glu Glu Glu Ser Leu Val Glu Gln Phe Val Phe Glu Ala Leu
    1090                1095                1100

 gtg ata tac atg gag agt ctg gcc tta gca cat gca gat gag aag tcc     3360
 Val Ile Tyr Met Glu Ser Leu Ala Leu Ala His Ala Asp Glu Lys Ser
1105                1110                1115                1120

 tta ggt aca att caa cag tgt tgt gat gcc att gat cac cta tgc cgc     3408
 Leu Gly Thr Ile Gln Gln Cys Cys Asp Ala Ile Asp His Leu Cys Arg
                1125                1130                1135

 atc att gaa aag aag cat gtt tct tta aat aaa gca aag aaa cga cgt     3456
 Ile Ile Glu Lys Lys His Val Ser Leu Asn Lys Ala Lys Lys Arg Arg
            1140                1145                1150

 ttg ccg cga gga ttt cca cct tcc gca tca ttg tgt tta ttg gat ctg     3504
 Leu Pro Arg Gly Phe Pro Pro Ser Ala Ser Leu Cys Leu Leu Asp Leu
        1155                1160                1165

 gtc aag tgg ctt tta gct cat tgt ggg agg ccc cag aca gaa tgt cga     3552
 Val Lys Trp Leu Leu Ala His Cys Gly Arg Pro Gln Thr Glu Cys Arg
    1170                1175                1180

 cac aaa tcc att gaa ctc ttt tat aaa ttc gtt cct tta ttg cca ggc     3600
 His Lys Ser Ile Glu Leu Phe Tyr Lys Phe Val Pro Leu Leu Pro Gly
1185                1190                1195                1200

 aac aga tcc cct aat ttg tgg ctg aaa gat gtt ctc aag gaa gaa ggt     3648
 Asn Arg Ser Pro Asn Leu Trp Leu Lys Asp Val Leu Lys Glu Glu Gly
                1205                1210                1215

 gtc tct ttt ctc atc aac acc ttt gag ggg ggt ggc tgt ggc cag ccc     3696
 Val Ser Phe Leu Ile Asn Thr Phe Glu Gly Gly Gly Cys Gly Gln Pro
            1220                1225                1230

 tcg ggc atc ctg gcc cag ccc acc ctc ttg tac ctt cgg ggg cca ttc     3744
 Ser Gly Ile Leu Ala Gln Pro Thr Leu Leu Tyr Leu Arg Gly Pro Phe
        1235                1240                1245

 agc ctg cag gcc acg cta tgc tgg ctg gac ctg ctc ctg gcc gcg ttg     3792
 Ser Leu Gln Ala Thr Leu Cys Trp Leu Asp Leu Leu Leu Ala Ala Leu
    1250                1255                1260

 gag tgc tac aac acg ttc att ggc gag aga act gta gga gcg ctc cag     3840
 Glu Cys Tyr Asn Thr Phe Ile Gly Glu Arg Thr Val Gly Ala Leu Gln
1265                1270                1275                1280

 gtc cta ggt act gaa gcc cag tct tca ctt ttg aaa gca gtg gct ttc     3888
 Val Leu Gly Thr Glu Ala Gln Ser Ser Leu Leu Lys Ala Val Ala Phe
                1285                1290                1295

 ttc tta gaa agc att gcc atg cat gac att ata gca gca gaa aag tgc     3936
 Phe Leu Glu Ser Ile Ala Met His Asp Ile Ile Ala Ala Glu Lys Cys
            1300                1305                1310

 ttt ggc act ggg gca gca ggt aac aga aca agc cca caa gag gga gaa     3984
 Phe Gly Thr Gly Ala Ala Gly Asn Arg Thr Ser Pro Gln Glu Gly Glu
        1315                1320                1325

 agg tac aac tac agc aaa tgc acc gtt gtg gtc cgg att atg gag ttt     4032
 Arg Tyr Asn Tyr Ser Lys Cys Thr Val Val Val Arg Ile Met Glu Phe
    1330                1335                1340

 acc acg act ctg cta aac acc tcc ccg gaa gga tgg aag ctc ctg aag     4080
 Thr Thr Thr Leu Leu Asn Thr Ser Pro Glu Gly Trp Lys Leu Leu Lys
1345                1350                1355                1360

 aag gac ttg tgt aat aca cac ctg atg aga gtc ctg gtg cag acg ctg     4128
 Lys Asp Leu Cys Asn Thr His Leu Met Arg Val Leu Val Gln Thr Leu
                1365                1370                1375

 tgt gag ccc gca agc ata ggt ttc aac atc gga gac gtc cag gtt atg     4176
 Cys Glu Pro Ala Ser Ile Gly Phe Asn Ile Gly Asp Val Gln Val Met
            1380                1385                1390

 gct cat ctt cct gat gtt tgt gtg aat ctg atg aaa gct cta aag atg     4224
 Ala His Leu Pro Asp Val Cys Val Asn Leu Met Lys Ala Leu Lys Met
        1395                1400                1405

 tcc cca tac aaa gat atc cta gag acc cat ctg aga gag aaa ata aca     4272
 Ser Pro Tyr Lys Asp Ile Leu Glu Thr His Leu Arg Glu Lys Ile Thr
    1410                1415                1420

 gca cag agc att gag gag ctt tgt gcc gtc aac ttg tat ggc cct gac     4320
 Ala Gln Ser Ile Glu Glu Leu Cys Ala Val Asn Leu Tyr Gly Pro Asp
1425                1430                1435                1440

 gcg caa gtg gac agg agc agg ctg gct gct gtt gtg tct gcc tgt aaa     4368
 Ala Gln Val Asp Arg Ser Arg Leu Ala Ala Val Val Ser Ala Cys Lys
                1445                1450                1455

 cag ctt cac aga gct ggg ctt ctg cat aat ata tta ccg tct cag tcc     4416
 Gln Leu His Arg Ala Gly Leu Leu His Asn Ile Leu Pro Ser Gln Ser
            1460                1465                1470

 aca gat ttg cat cat tct gtt ggc aca gaa ctt ctt tcc ctg gtt tat     4464
 Thr Asp Leu His His Ser Val Gly Thr Glu Leu Leu Ser Leu Val Tyr
        1475                1480                1485

 aaa ggc att gcc cct gga gat gag aga cag tgt ctg cct tct cta gac     4512
 Lys Gly Ile Ala Pro Gly Asp Glu Arg Gln Cys Leu Pro Ser Leu Asp
    1490                1495                1500

 ctc agt tgt aag cag ctg gcc agc gga ctt ctg gag tta gcc ttt gct     4560
 Leu Ser Cys Lys Gln Leu Ala Ser Gly Leu Leu Glu Leu Ala Phe Ala
1505                1510                1515                1520

 ttt gga gga ctg tgt gag cgc ctt gtg agt ctt ctc ctg aac cca gcg     4608
 Phe Gly Gly Leu Cys Glu Arg Leu Val Ser Leu Leu Leu Asn Pro Ala
                1525                1530                1535

 gtg ctg tcc acg gcg tcc ttg ggc agc tca cag ggc agc gtc atc cac     4656
 Val Leu Ser Thr Ala Ser Leu Gly Ser Ser Gln Gly Ser Val Ile His
            1540                1545                1550

 ttc tcc cat ggg gag tat ttc tat agc ttg ttc tca gaa acg atc aac     4704
 Phe Ser His Gly Glu Tyr Phe Tyr Ser Leu Phe Ser Glu Thr Ile Asn
        1555                1560                1565

 acg gaa tta ttg aaa aat ctg gat ctt gct gta ttg gag ctc atg cag     4752
 Thr Glu Leu Leu Lys Asn Leu Asp Leu Ala Val Leu Glu Leu Met Gln
    1570                1575                1580

 tct tca gtg gat aat acc aaa atg gtg agt gcc gtt ttg aac ggc atg     4800
 Ser Ser Val Asp Asn Thr Lys Met Val Ser Ala Val Leu Asn Gly Met
1585                1590                1595                1600

 tta gac cag agc ttc agg gag cga gca aac cag aaa cac caa gga ctg     4848
 Leu Asp Gln Ser Phe Arg Glu Arg Ala Asn Gln Lys His Gln Gly Leu
                1605                1610                1615

 aaa ctt gcg act aca att ctg caa cac tgg aag aag tgt gat tca tgg     4896
 Lys Leu Ala Thr Thr Ile Leu Gln His Trp Lys Lys Cys Asp Ser Trp
            1620                1625                1630

 tgg gcc aaa gat tcc cct ctc gaa act aaa atg gca gtg ctg gcc tta     4944
 Trp Ala Lys Asp Ser Pro Leu Glu Thr Lys Met Ala Val Leu Ala Leu
        1635                1640                1645

 ctg gca aaa att tta cag att gat tca tct gta tct ttt aat aca agt     4992
 Leu Ala Lys Ile Leu Gln Ile Asp Ser Ser Val Ser Phe Asn Thr Ser
    1650                1655                1660

 cat ggt tca ttc cct gaa gtc ttt aca aca tat att agt cta ctt gct     5040
 His Gly Ser Phe Pro Glu Val Phe Thr Thr Tyr Ile Ser Leu Leu Ala
1665                1670                1675                1680

 gac aca aag ctg gat cta cat tta aag ggc caa gct gtc act ctt ctt     5088
 Asp Thr Lys Leu Asp Leu His Leu Lys Gly Gln Ala Val Thr Leu Leu
                1685                1690                1695

 cca ttc ttc acc agc ctc act gga ggc agt ctg gag gaa ctt aga cgt     5136
 Pro Phe Phe Thr Ser Leu Thr Gly Gly Ser Leu Glu Glu Leu Arg Arg
            1700                1705                1710

 gtt ctg gag cag ctc atc gtt gct cac ttc ccc atg cag tcc agg gaa     5184
 Val Leu Glu Gln Leu Ile Val Ala His Phe Pro Met Gln Ser Arg Glu
        1715                1720                1725

 ttt cct cca gga act ccg cgg ttc aat aat tat gtg gac tgc atg aaa     5232
 Phe Pro Pro Gly Thr Pro Arg Phe Asn Asn Tyr Val Asp Cys Met Lys
    1730                1735                1740

 aag ttt cta gat gca ttg gaa tta tct caa agc cct atg ttg ttg gaa     5280
 Lys Phe Leu Asp Ala Leu Glu Leu Ser Gln Ser Pro Met Leu Leu Glu
1745                1750                1755                1760

 ttg atg aca gaa gtt ctt tgt cgg gaa cag cag cat gtc atg gaa gaa     5328
 Leu Met Thr Glu Val Leu Cys Arg Glu Gln Gln His Val Met Glu Glu
                1765                1770                1775

 tta ttt caa tcc agt ttc agg agg att gcc aga agg ggt tca tgt gtc     5376
 Leu Phe Gln Ser Ser Phe Arg Arg Ile Ala Arg Arg Gly Ser Cys Val
            1780                1785                1790

 aca caa gta ggc ctt ctg gaa agc gtg tat gaa atg ttc agg aag gat     5424
 Thr Gln Val Gly Leu Leu Glu Ser Val Tyr Glu Met Phe Arg Lys Asp
        1795                1800                1805

 gac ccc cgc cta agt ttc aca cgc cag tcc ttt gtg gac cgc tcc ctc     5472
 Asp Pro Arg Leu Ser Phe Thr Arg Gln Ser Phe Val Asp Arg Ser Leu
    1810                1815                1820

 ctc act ctg ctg tgg cac tgt agc ctg gat gct ttg aga gaa ttc ttc     5520
 Leu Thr Leu Leu Trp His Cys Ser Leu Asp Ala Leu Arg Glu Phe Phe
1825                1830                1835                1840

 agc aca att gtg gtg gat gcc att gat gtg ttg aag tcc agg ttt aca     5568
 Ser Thr Ile Val Val Asp Ala Ile Asp Val Leu Lys Ser Arg Phe Thr
                1845                1850                1855

 aag cta aat gaa tct acc ttt gat act caa atc acc aag aag atg ggc     5616
 Lys Leu Asn Glu Ser Thr Phe Asp Thr Gln Ile Thr Lys Lys Met Gly
            1860                1865                1870

 tac tat aag att cta gac gtg atg tat tct cgc ctt ccc aaa gat gat     5664
 Tyr Tyr Lys Ile Leu Asp Val Met Tyr Ser Arg Leu Pro Lys Asp Asp
        1875                1880                1885

 gtt cat gct aag gaa tca aaa att aat caa gtt ttc cat ggc tcg tgt     5712
 Val His Ala Lys Glu Ser Lys Ile Asn Gln Val Phe His Gly Ser Cys
    1890                1895                1900

 att aca gaa gga aat gaa ctt aca aag aca ttg att aaa ttg tgc tac     5760
 Ile Thr Glu Gly Asn Glu Leu Thr Lys Thr Leu Ile Lys Leu Cys Tyr
1905                1910                1915                1920

 gat gca ttt aca gag aac atg gca gga gag aat cag ctg ctg gag agg     5808
 Asp Ala Phe Thr Glu Asn Met Ala Gly Glu Asn Gln Leu Leu Glu Arg
                1925                1930                1935

 aga aga ctt tac cat tgt gca gca tac aac tgc gcc ata tct gtc atc     5856
 Arg Arg Leu Tyr His Cys Ala Ala Tyr Asn Cys Ala Ile Ser Val Ile
            1940                1945                1950

 tgc tgt gtc ttc aat gag tta aaa ttt tac caa ggt ttt ctg ttt agt     5904
 Cys Cys Val Phe Asn Glu Leu Lys Phe Tyr Gln Gly Phe Leu Phe Ser
        1955                1960                1965

 gaa aaa cca gaa aag aac ttg ctt att ttt gaa aat ctg atc gac ctg     5952
 Glu Lys Pro Glu Lys Asn Leu Leu Ile Phe Glu Asn Leu Ile Asp Leu
    1970                1975                1980

 aag cgc cgc tat aat ttt cct gta gaa gtt gag gtt cct atg gaa aga     6000
 Lys Arg Arg Tyr Asn Phe Pro Val Glu Val Glu Val Pro Met Glu Arg
1985                1990                1995                2000

 aag aaa aag tac att gaa att agg aaa gaa gcc aga gaa gca gca aat     6048
 Lys Lys Lys Tyr Ile Glu Ile Arg Lys Glu Ala Arg Glu Ala Ala Asn
                2005                2010                2015

 ggg gat tca gat ggt cct tcc tat atg tct tcc ctg tca tat ttg gca     6096
 Gly Asp Ser Asp Gly Pro Ser Tyr Met Ser Ser Leu Ser Tyr Leu Ala
            2020                2025                2030

 gac agt acc ctg agt gag gaa atg agt caa ttt gat ttc tca acc gga     6144
 Asp Ser Thr Leu Ser Glu Glu Met Ser Gln Phe Asp Phe Ser Thr Gly
        2035                2040                2045

 gtt cag agc tat tca tac agc tcc caa gac cct aga cct gcc act ggt     6192
 Val Gln Ser Tyr Ser Tyr Ser Ser Gln Asp Pro Arg Pro Ala Thr Gly
    2050                2055                2060

 cgt ttt cgg aga cgg gag cag cgg gac ccc acg gtg cat gat gat gtg     6240
 Arg Phe Arg Arg Arg Glu Gln Arg Asp Pro Thr Val His Asp Asp Val
2065                2070                2075                2080

 ctg gag ctg gag atg gac gag ctc aat cgg cat gag tgc atg gcg ccc     6288
 Leu Glu Leu Glu Met Asp Glu Leu Asn Arg His Glu Cys Met Ala Pro
                2085                2090                2095

 ctg acg gcc ctg gtc aag cac atg cac aga agc ctg ggc ccg cct caa     6336
 Leu Thr Ala Leu Val Lys His Met His Arg Ser Leu Gly Pro Pro Gln
            2100                2105                2110

 gga gaa gag gat tca gtg cca aga gat ctt cct tct tgg atg aaa ttc     6384
 Gly Glu Glu Asp Ser Val Pro Arg Asp Leu Pro Ser Trp Met Lys Phe
        2115                2120                2125

 ctc cat ggc aaa ctg gga aat cca ata gta cca tta aat atc cgt ctc     6432
 Leu His Gly Lys Leu Gly Asn Pro Ile Val Pro Leu Asn Ile Arg Leu
    2130                2135                2140

 ttc tta gcc aag ctt gtt att aat aca gaa gag gtc ttt cgc cct tac     6480
 Phe Leu Ala Lys Leu Val Ile Asn Thr Glu Glu Val Phe Arg Pro Tyr
2145                2150                2155                2160

 gcg aag cac tgg ctt agc ccc ttg ctg cag ctg gct gct tct gaa aac     6528
 Ala Lys His Trp Leu Ser Pro Leu Leu Gln Leu Ala Ala Ser Glu Asn
                2165                2170                2175

 aat gga gga gaa gga att cac tac atg gtg gtt gag ata gtg gcc act     6576
 Asn Gly Gly Glu Gly Ile His Tyr Met Val Val Glu Ile Val Ala Thr
            2180                2185                2190

 att ctt tca tgg aca ggc ttg gcc act cca aca ggg gtc cct aaa gat     6624
 Ile Leu Ser Trp Thr Gly Leu Ala Thr Pro Thr Gly Val Pro Lys Asp
        2195                2200                2205

 gaa gtg tta gca aat cga ttg ctt aat ttc cta atg aaa cat gtc ttt     6672
 Glu Val Leu Ala Asn Arg Leu Leu Asn Phe Leu Met Lys His Val Phe
    2210                2215                2220

 cat cca aaa aga gct gtg ttt aga cac aac ctt gaa att ata aag acc     6720
 His Pro Lys Arg Ala Val Phe Arg His Asn Leu Glu Ile Ile Lys Thr
2225                2230                2235                2240

 ctt gtc gag tgc tgg aag gat tgt tta tcc atc cct tat agg tta ata     6768
 Leu Val Glu Cys Trp Lys Asp Cys Leu Ser Ile Pro Tyr Arg Leu Ile
                2245                2250                2255

 ttt gaa aag ttt tcc ggt aaa gat cct aat tct aaa gac aac tca gta     6816
 Phe Glu Lys Phe Ser Gly Lys Asp Pro Asn Ser Lys Asp Asn Ser Val
            2260                2265                2270

 ggg att caa ttg cta ggc atc gtg atg gcc aat gac ctg cct ccc tat     6864
 Gly Ile Gln Leu Leu Gly Ile Val Met Ala Asn Asp Leu Pro Pro Tyr
        2275                2280                2285

 gac cca cag tgt ggc atc cag agt agc gaa tac ttc cag gct ttg gtg     6912
 Asp Pro Gln Cys Gly Ile Gln Ser Ser Glu Tyr Phe Gln Ala Leu Val
    2290                2295                2300

 aat aat atg tcc ttt gta aga tat aaa gaa gtg tat gcc gct gca gca     6960
 Asn Asn Met Ser Phe Val Arg Tyr Lys Glu Val Tyr Ala Ala Ala Ala
2305                2310                2315                2320

 gaa gtt cta gga ctt ata ctt cga tat gtt atg gag aga aaa aac ata     7008
 Glu Val Leu Gly Leu Ile Leu Arg Tyr Val Met Glu Arg Lys Asn Ile
                2325                2330                2335

 ctg gag gag tct ctg tgt gaa ctg gtt gcg aaa caa ttg aag caa cat     7056
 Leu Glu Glu Ser Leu Cys Glu Leu Val Ala Lys Gln Leu Lys Gln His
            2340                2345                2350

 cag aat act atg gag gac aag ttt att gtg tgc ttg aac aaa gtg acc     7104
 Gln Asn Thr Met Glu Asp Lys Phe Ile Val Cys Leu Asn Lys Val Thr
        2355                2360                2365

 aag agc ttc cct cct ctt gca gac agg ttc atg aat gct gtg ttc ttt     7152
 Lys Ser Phe Pro Pro Leu Ala Asp Arg Phe Met Asn Ala Val Phe Phe
    2370                2375                2380

 ctg ctg cca aaa ttt cat gga gtg ttg aaa aca ctc tgt ctg gag gtg     7200
 Leu Leu Pro Lys Phe His Gly Val Leu Lys Thr Leu Cys Leu Glu Val
2385                2390                2395                2400

 gta ctt tgt cgt gtg gag gga atg aca gag ctg tac ttc cag tta aag     7248
 Val Leu Cys Arg Val Glu Gly Met Thr Glu Leu Tyr Phe Gln Leu Lys
                2405                2410                2415

 agc aag gac ttc gtt caa gtc atg aga cat aga gat gat gaa aga caa     7296
 Ser Lys Asp Phe Val Gln Val Met Arg His Arg Asp Asp Glu Arg Gln
            2420                2425                2430

 aaa gta tgt ttg gac ata att tat aag atg atg cca aag tta aaa cca     7344
 Lys Val Cys Leu Asp Ile Ile Tyr Lys Met Met Pro Lys Leu Lys Pro
        2435                2440                2445

 gta gaa ctc cga gaa ctt ctg aac ccc gtt gtg gaa ttc gtt tcc cat     7392
 Val Glu Leu Arg Glu Leu Leu Asn Pro Val Val Glu Phe Val Ser His
    2450                2455                2460

 cct tct aca aca tgt agg gaa caa atg tat aat att ctc atg tgg att     7440
 Pro Ser Thr Thr Cys Arg Glu Gln Met Tyr Asn Ile Leu Met Trp Ile
2465                2470                2475                2480

 cat gat aat tac aga gat cca gaa agt gag aca gat aat gac tcc cag     7488
 His Asp Asn Tyr Arg Asp Pro Glu Ser Glu Thr Asp Asn Asp Ser Gln
                2485                2490                2495

 gaa ata ttt aag ttg gca aaa gat gtg ctg att caa gga ttg atc gat     7536
 Glu Ile Phe Lys Leu Ala Lys Asp Val Leu Ile Gln Gly Leu Ile Asp
            2500                2505                2510

 gag aac cct gga ctt caa tta att att cga aat ttc tgg agc cat gaa     7584
 Glu Asn Pro Gly Leu Gln Leu Ile Ile Arg Asn Phe Trp Ser His Glu
        2515                2520                2525

 act agg tta cct tca aat acc ttg gac cgg ttg ctg gca cta aat tcc     7632
 Thr Arg Leu Pro Ser Asn Thr Leu Asp Arg Leu Leu Ala Leu Asn Ser
    2530                2535                2540

 tta tat tct cct aag ata gaa gtg cac ttt tta agt tta gca aca aat     7680
 Leu Tyr Ser Pro Lys Ile Glu Val His Phe Leu Ser Leu Ala Thr Asn
2545                2550                2555                2560

 ttt ctg ctc gaa atg acc agc atg agc cca gat tat cca aac ccc atg     7728
 Phe Leu Leu Glu Met Thr Ser Met Ser Pro Asp Tyr Pro Asn Pro Met
                2565                2570                2575

 ttc gag cat cct ctg tca gaa tgc gaa ttt cag gaa tat acc att gat     7776
 Phe Glu His Pro Leu Ser Glu Cys Glu Phe Gln Glu Tyr Thr Ile Asp
            2580                2585                2590

 tct gat tgg cgt ttc cga agt act gtt ctc act ccg atg ttt gtg gag     7824
 Ser Asp Trp Arg Phe Arg Ser Thr Val Leu Thr Pro Met Phe Val Glu
        2595                2600                2605

 acc cag gcc tcc cag ggc act ctc cag acc cgt acc cag gaa ggg tcc     7872
 Thr Gln Ala Ser Gln Gly Thr Leu Gln Thr Arg Thr Gln Glu Gly Ser
    2610                2615                2620

 ctc tca gct cgc tgg cca gtg gca ggg cag ata agg gcc acc cag cag     7920
 Leu Ser Ala Arg Trp Pro Val Ala Gly Gln Ile Arg Ala Thr Gln Gln
2625                2630                2635                2640

 cag cat gac ttc aca ctg aca cag act gca gat gga aga agc tca ttt     7968
 Gln His Asp Phe Thr Leu Thr Gln Thr Ala Asp Gly Arg Ser Ser Phe
                2645                2650                2655

 gat tgg ctg acc ggg agc agc act gac ccg ctg gtc gac cac acc agt     8016
 Asp Trp Leu Thr Gly Ser Ser Thr Asp Pro Leu Val Asp His Thr Ser
            2660                2665                2670

 ccc tca tct gac tcc ttg ctg ttt gcc cac aag agg agt gaa agg tta     8064
 Pro Ser Ser Asp Ser Leu Leu Phe Ala His Lys Arg Ser Glu Arg Leu
        2675                2680                2685

 cag aga gca ccc ttg aag tca gtg ggg cct gat ttt ggg aaa aaa agg     8112
 Gln Arg Ala Pro Leu Lys Ser Val Gly Pro Asp Phe Gly Lys Lys Arg
    2690                2695                2700

 ctg ggc ctt cca ggg gac gag gtg gat aac aaa gtg aaa ggt gcg gcc     8160
 Leu Gly Leu Pro Gly Asp Glu Val Asp Asn Lys Val Lys Gly Ala Ala
2705                2710                2715                2720

 ggc cgg acg gac cta cta cga ctg cgc aga cgg ttt atg agg gac cag     8208
 Gly Arg Thr Asp Leu Leu Arg Leu Arg Arg Arg Phe Met Arg Asp Gln
                2725                2730                2735

 gag aag ctc agt ttg atg tat gcc aga aaa ggc gtt gct gag caa aaa     8256
 Glu Lys Leu Ser Leu Met Tyr Ala Arg Lys Gly Val Ala Glu Gln Lys
            2740                2745                2750

 cga gag aag gaa atc aag agt gag tta aaa atg aag cag gat gcc cag     8304
 Arg Glu Lys Glu Ile Lys Ser Glu Leu Lys Met Lys Gln Asp Ala Gln
        2755                2760                2765

 gtc gtt ctg tac aga agc tac cgg cac gga gac ctt cct gac att cag     8352
 Val Val Leu Tyr Arg Ser Tyr Arg His Gly Asp Leu Pro Asp Ile Gln
    2770                2775                2780

 atc aag cac agc agc ctc atc acc ccg tta cag gcc gtg gcc cag agg     8400
 Ile Lys His Ser Ser Leu Ile Thr Pro Leu Gln Ala Val Ala Gln Arg
2785                2790                2795                2800

 gac cca ata att gca aaa cag ctc ttt agc agc ttg ttt tct gga att     8448
 Asp Pro Ile Ile Ala Lys Gln Leu Phe Ser Ser Leu Phe Ser Gly Ile
                2805                2810                2815

 ttg aaa gag atg gat aaa ttt aag aca ctg tct gaa aaa aac aac atc     8496
 Leu Lys Glu Met Asp Lys Phe Lys Thr Leu Ser Glu Lys Asn Asn Ile
            2820                2825                2830

 act caa aag ttg ctt caa gac ttc aat cgt ttt ctt aat acc acc ttc     8544
 Thr Gln Lys Leu Leu Gln Asp Phe Asn Arg Phe Leu Asn Thr Thr Phe
        2835                2840                2845

 tct ttc ttt cca ccc ttt gtc tct tgt att cag gac att agc tgt cag     8592
 Ser Phe Phe Pro Pro Phe Val Ser Cys Ile Gln Asp Ile Ser Cys Gln
    2850                2855                2860

 cac gca gcc ctg ctg agc ctc gac cca gcg gct gtt agc gct ggt tgc     8640
 His Ala Ala Leu Leu Ser Leu Asp Pro Ala Ala Val Ser Ala Gly Cys
2865                2870                2875                2880

 ctg gcc agc cta cag cag ccc gtg ggc atc cgc ctg cta gag gag gct     8688
 Leu Ala Ser Leu Gln Gln Pro Val Gly Ile Arg Leu Leu Glu Glu Ala
                2885                2890                2895

 ctg ctc cgc ctg ctg cct gct gag ctg cct gcc aag cga gtc cgt ggg     8736
 Leu Leu Arg Leu Leu Pro Ala Glu Leu Pro Ala Lys Arg Val Arg Gly
            2900                2905                2910

 aag gcc cgc ctc cct cct gat gtc ctc aga tgg gtg gag ctt gct aag     8784
 Lys Ala Arg Leu Pro Pro Asp Val Leu Arg Trp Val Glu Leu Ala Lys
        2915                2920                2925

 ctg tat aga tca att gga gaa tac gac gtc ctc cgt ggg att ttt acc     8832
 Leu Tyr Arg Ser Ile Gly Glu Tyr Asp Val Leu Arg Gly Ile Phe Thr
    2930                2935                2940

 agt gag ata gga aca aag caa atc act cag agt gca tta tta gca gaa     8880
 Ser Glu Ile Gly Thr Lys Gln Ile Thr Gln Ser Ala Leu Leu Ala Glu
2945                2950                2955                2960

 gcc aga agt gat tat tct gaa gct gct aag cag tat gat gag gct ctc     8928
 Ala Arg Ser Asp Tyr Ser Glu Ala Ala Lys Gln Tyr Asp Glu Ala Leu
                2965                2970                2975

 aat aaa caa gac tgg gta gat ggt gag ccc aca gaa gcc gag aag gat     8976
 Asn Lys Gln Asp Trp Val Asp Gly Glu Pro Thr Glu Ala Glu Lys Asp
            2980                2985                2990

 ttt tgg gaa ctt gca tcc ctt gac tgt tac aac cac ctt gct gag tgg     9024
 Phe Trp Glu Leu Ala Ser Leu Asp Cys Tyr Asn His Leu Ala Glu Trp
        2995                3000                3005

 aaa tca ctt gaa tac tgt tct aca gcc agt ata gac agt gag aac ccc     9072
 Lys Ser Leu Glu Tyr Cys Ser Thr Ala Ser Ile Asp Ser Glu Asn Pro
    3010                3015                3020

 cca gac cta aat aaa atc tgg agt gaa cca ttt tat cag gaa aca tat     9120
 Pro Asp Leu Asn Lys Ile Trp Ser Glu Pro Phe Tyr Gln Glu Thr Tyr
3025                3030                3035                3040

 cta cct tac atg atc cgc agc aag ctg aag ctg ctg ctc cag gga gag     9168
 Leu Pro Tyr Met Ile Arg Ser Lys Leu Lys Leu Leu Leu Gln Gly Glu
                3045                3050                3055

 gct gac cag tcc ctg ctg aca ttt att gac aaa gct atg cac ggg gag     9216
 Ala Asp Gln Ser Leu Leu Thr Phe Ile Asp Lys Ala Met His Gly Glu
            3060                3065                3070

 ctc cag aag gcg att cta gag ctt cat tac agt caa gag ctg agt ctg     9264
 Leu Gln Lys Ala Ile Leu Glu Leu His Tyr Ser Gln Glu Leu Ser Leu
        3075                3080                3085

 ctt tac ctc ctg caa gat gat gtt gac aga gcc aaa tat tac att caa     9312
 Leu Tyr Leu Leu Gln Asp Asp Val Asp Arg Ala Lys Tyr Tyr Ile Gln
    3090                3095                3100

 aat ggc att cag agt ttt atg cag aat tat tct agt att gat gtc ctc     9360
 Asn Gly Ile Gln Ser Phe Met Gln Asn Tyr Ser Ser Ile Asp Val Leu
3105                3110                3115                3120

 tta cac caa agt aga ctc acc aaa ttg cag tct gta cag gct tta aca     9408
 Leu His Gln Ser Arg Leu Thr Lys Leu Gln Ser Val Gln Ala Leu Thr
                3125                3130                3135

 gaa att cag gag ttc atc agc ttt ata agc aaa caa ggc aat tta tca     9456
 Glu Ile Gln Glu Phe Ile Ser Phe Ile Ser Lys Gln Gly Asn Leu Ser
            3140                3145                3150

 tct caa gtt ccc ctt aag aga ctt ctg aac acc tgg aca aac aga tat     9504
 Ser Gln Val Pro Leu Lys Arg Leu Leu Asn Thr Trp Thr Asn Arg Tyr
        3155                3160                3165

 cca gat gct aaa atg gac cca atg aac atc tgg gat gac atc atc aca     9552
 Pro Asp Ala Lys Met Asp Pro Met Asn Ile Trp Asp Asp Ile Ile Thr
    3170                3175                3180

 aat cga tgt ttc ttt ctc agc aaa ata gag gag aag ctt acc cct ctt     9600
 Asn Arg Cys Phe Phe Leu Ser Lys Ile Glu Glu Lys Leu Thr Pro Leu
3185                3190                3195                3200

 cca gaa gat aat agt atg aat gtg gat caa gat gga gac ccc agt gac     9648
 Pro Glu Asp Asn Ser Met Asn Val Asp Gln Asp Gly Asp Pro Ser Asp
                3205                3210                3215

 agg atg gaa gtg caa gag cag gaa gaa gat atc agc tcc ctg atc agg     9696
 Arg Met Glu Val Gln Glu Gln Glu Glu Asp Ile Ser Ser Leu Ile Arg
            3220                3225                3230

 agt tgc aag ttt tcc atg aaa atg aag atg ata gac agt gcc cgg aag     9744
 Ser Cys Lys Phe Ser Met Lys Met Lys Met Ile Asp Ser Ala Arg Lys
        3235                3240                3245

 cag aac aat ttc tca ctt gct atg aaa cta ctg aag gag ctg cat aaa     9792
 Gln Asn Asn Phe Ser Leu Ala Met Lys Leu Leu Lys Glu Leu His Lys
    3250                3255                3260

 gag tca aaa acc aga gac gat tgg ctg gtg agc tgg gtg cag agc tac     9840
 Glu Ser Lys Thr Arg Asp Asp Trp Leu Val Ser Trp Val Gln Ser Tyr
3265                3270                3275                3280

 tgc cgc ctg agc cac tgc cgg agc cgg tcc cag ggc tgc tct gag cag     9888
 Cys Arg Leu Ser His Cys Arg Ser Arg Ser Gln Gly Cys Ser Glu Gln
                3285                3290                3295

 gtg ctc act gtg ctg aaa aca gtc tct ttg ttg gat gag aac aac gtg     9936
 Val Leu Thr Val Leu Lys Thr Val Ser Leu Leu Asp Glu Asn Asn Val
            3300                3305                3310

 tca agc tac tta agc aaa aat att ctg gct ttc cgt gac cag aac att     9984
 Ser Ser Tyr Leu Ser Lys Asn Ile Leu Ala Phe Arg Asp Gln Asn Ile
        3315                3320                3325

 ctc ttg ggt aca act tac agg atc ata gcg aat gct ctc agc agt gag    10032
 Leu Leu Gly Thr Thr Tyr Arg Ile Ile Ala Asn Ala Leu Ser Ser Glu
    3330                3335                3340

 cca gcc tgc ctt gct gaa atc gag gag gac aag gct aga aga atc tta    10080
 Pro Ala Cys Leu Ala Glu Ile Glu Glu Asp Lys Ala Arg Arg Ile Leu
3345                3350                3355                3360

 gag ctt tct gga tcc agt tca gag gat tca gag aag gtg atc gcg ggt    10128
 Glu Leu Ser Gly Ser Ser Ser Glu Asp Ser Glu Lys Val Ile Ala Gly
                3365                3370                3375

 ctg tac cag aga gca ttc cag cac ctc tct gag gct gtg cag gcg gct    10176
 Leu Tyr Gln Arg Ala Phe Gln His Leu Ser Glu Ala Val Gln Ala Ala
            3380                3385                3390

 gag gag gag gcc cag cct ccc tcc tgg agc tgt ggg cct gca gct ggg    10224
 Glu Glu Glu Ala Gln Pro Pro Ser Trp Ser Cys Gly Pro Ala Ala Gly
        3395                3400                3405

 gtg att gat gct tac atg acg ctg gca gat ttc tgt gac caa cag ctg    10272
 Val Ile Asp Ala Tyr Met Thr Leu Ala Asp Phe Cys Asp Gln Gln Leu
    3410                3415                3420

 cgc aag gag gaa gag aat gca tca gtt att gat tct gca gaa ctg cag    10320
 Arg Lys Glu Glu Glu Asn Ala Ser Val Ile Asp Ser Ala Glu Leu Gln
3425                3430                3435                3440

 gcg tat cca gca ctt gtg gtg gag aaa atg ttg aaa gct tta aaa tta    10368
 Ala Tyr Pro Ala Leu Val Val Glu Lys Met Leu Lys Ala Leu Lys Leu
                3445                3450                3455

 aat tcc aat gaa gcc aga ttg aag ttt cct aga tta ctt cag att ata    10416
 Asn Ser Asn Glu Ala Arg Leu Lys Phe Pro Arg Leu Leu Gln Ile Ile
            3460                3465                3470

 gaa cgg tat cca gag gag act ttg agc ctc atg aca aaa gag atc tct    10464
 Glu Arg Tyr Pro Glu Glu Thr Leu Ser Leu Met Thr Lys Glu Ile Ser
        3475                3480                3485

 tcc gtt ccc tgc tgg cag ttc atc agc tgg atc agc cac atg gtg gcc    10512
 Ser Val Pro Cys Trp Gln Phe Ile Ser Trp Ile Ser His Met Val Ala
    3490                3495                3500

 tta ctg gac aaa gac caa gcc gtt gct gtt cag cac tct gtg gaa gaa    10560
 Leu Leu Asp Lys Asp Gln Ala Val Ala Val Gln His Ser Val Glu Glu
3505                3510                3515                3520

 atc act gat aac tac ccg cag gct att gtt tat ccc ttc atc ata agc    10608
 Ile Thr Asp Asn Tyr Pro Gln Ala Ile Val Tyr Pro Phe Ile Ile Ser
                3525                3530                3535

 agc gaa agc tat tcc ttc aag gat act tct act ggt cat aag aat aag    10656
 Ser Glu Ser Tyr Ser Phe Lys Asp Thr Ser Thr Gly His Lys Asn Lys
            3540                3545                3550

 gag ttt gtg gca agg att aaa agt aag ttg gat caa gga gga gtg att    10704
 Glu Phe Val Ala Arg Ile Lys Ser Lys Leu Asp Gln Gly Gly Val Ile
        3555                3560                3565

 caa gat ttt att aat gcc tta gat cag ctc tct aat cct gaa ctg ctc    10752
 Gln Asp Phe Ile Asn Ala Leu Asp Gln Leu Ser Asn Pro Glu Leu Leu
    3570                3575                3580

 ttt aag gat tgg agc aat gat gta aga gct gaa cta gca aaa acc cct    10800
 Phe Lys Asp Trp Ser Asn Asp Val Arg Ala Glu Leu Ala Lys Thr Pro
3585                3590                3595                3600

 gta aat aaa aaa aac att gaa aaa atg tat gaa aga atg tat gca gcc    10848
 Val Asn Lys Lys Asn Ile Glu Lys Met Tyr Glu Arg Met Tyr Ala Ala
                3605                3610                3615

 ttg ggt gac cca aag gct cca ggc ctg ggg gcc ttt aga agg aag ttt    10896
 Leu Gly Asp Pro Lys Ala Pro Gly Leu Gly Ala Phe Arg Arg Lys Phe
            3620                3625                3630

 att cag act ttt gga aaa gaa ttt gat aaa cat ttt ggg aaa gga ggt    10944
 Ile Gln Thr Phe Gly Lys Glu Phe Asp Lys His Phe Gly Lys Gly Gly
        3635                3640                3645

 tct aaa cta ctg aga atg aag ctc agt gac ttc aac gac att acc aac    10992
 Ser Lys Leu Leu Arg Met Lys Leu Ser Asp Phe Asn Asp Ile Thr Asn
    3650                3655                3660

 atg cta ctt tta aaa atg aac aaa gac tca aag ccc cct ggg aat ctg    11040
 Met Leu Leu Leu Lys Met Asn Lys Asp Ser Lys Pro Pro Gly Asn Leu
3665                3670                3675                3680

 aaa gaa tgt tca ccc tgg atg agc gac ttc aaa gtg gag ttc ctg aga    11088
 Lys Glu Cys Ser Pro Trp Met Ser Asp Phe Lys Val Glu Phe Leu Arg
                3685                3690                3695

 aat gag ctg gag att ccc ggt cag tat gac ggt agg gga aag cca ttg    11136
 Asn Glu Leu Glu Ile Pro Gly Gln Tyr Asp Gly Arg Gly Lys Pro Leu
            3700                3705                3710

 cca gag tac cac gtg cga atc gcc ggg ttt gat gag cgg gtg aca gtc    11184
 Pro Glu Tyr His Val Arg Ile Ala Gly Phe Asp Glu Arg Val Thr Val
        3715                3720                3725

 atg gcg tct ctg cga agg ccc aag cgc atc atc atc cgt ggc cat gac    11232
 Met Ala Ser Leu Arg Arg Pro Lys Arg Ile Ile Ile Arg Gly His Asp
    3730                3735                3740

 gag agg gaa cac cct ttc ctg gtg aag ggt ggc gag gac ctg cgg cag    11280
 Glu Arg Glu His Pro Phe Leu Val Lys Gly Gly Glu Asp Leu Arg Gln
3745                3750                3755                3760

 gac cag cgc gtg gag cag ctc ttc cag gtc atg aat ggg atc ctg gcc    11328
 Asp Gln Arg Val Glu Gln Leu Phe Gln Val Met Asn Gly Ile Leu Ala
                3765                3770                3775

 caa gac tcc gcc tgc agc cag agg gcc ctg cag ctg agg acc tat agc    11376
 Gln Asp Ser Ala Cys Ser Gln Arg Ala Leu Gln Leu Arg Thr Tyr Ser
            3780                3785                3790

 gtt gtg ccc atg acc tcc agg tta gga tta att gag tgg ctt gaa aat    11424
 Val Val Pro Met Thr Ser Arg Leu Gly Leu Ile Glu Trp Leu Glu Asn
        3795                3800                3805

 act gtt acc ttg aag gac ctt ctt ttg aac acc atg tcc caa gag gag    11472
 Thr Val Thr Leu Lys Asp Leu Leu Leu Asn Thr Met Ser Gln Glu Glu
    3810                3815                3820

 aag gcg gct tac ctg agt gat ccc agg gca ccg ccg tgt gaa tat aaa    11520
 Lys Ala Ala Tyr Leu Ser Asp Pro Arg Ala Pro Pro Cys Glu Tyr Lys
3825                3830                3835                3840

 gat tgg ctg aca aaa atg tca gga aaa cat gat gtt gga gct tac atg    11568
 Asp Trp Leu Thr Lys Met Ser Gly Lys His Asp Val Gly Ala Tyr Met
                3845                3850                3855

 cta atg tat aag ggc gct aat cgt act gaa aca gtc acg tct ttt aga    11616
 Leu Met Tyr Lys Gly Ala Asn Arg Thr Glu Thr Val Thr Ser Phe Arg
            3860                3865                3870

 aaa cga gaa agt aaa gtg cct gct gat ctc tta aag cgg gcc ttc gtg    11664
 Lys Arg Glu Ser Lys Val Pro Ala Asp Leu Leu Lys Arg Ala Phe Val
        3875                3880                3885

 agg atg agt aca agc cct gag gct ttc ctg gcg ctc cgc tcc cac ttc    11712
 Arg Met Ser Thr Ser Pro Glu Ala Phe Leu Ala Leu Arg Ser His Phe
    3890                3895                3900

 gcc agc tct cac gct ctg ata tgc atc agc cac tgg atc ctc ggg att    11760
 Ala Ser Ser His Ala Leu Ile Cys Ile Ser His Trp Ile Leu Gly Ile
3905                3910                3915                3920

 gga gac aga cat ctg aac aac ttt atg gtg gcc atg gag act ggc ggc    11808
 Gly Asp Arg His Leu Asn Asn Phe Met Val Ala Met Glu Thr Gly Gly
                3925                3930                3935

 gtg atc ggg atc gac ttt ggg cat gcg ttt gga tcc gct aca cag ttt    11856
 Val Ile Gly Ile Asp Phe Gly His Ala Phe Gly Ser Ala Thr Gln Phe
            3940                3945                3950

 ctg cca gtc cct gag ttg atg cct ttt cgg cta act cgc cag ttt atc    11904
 Leu Pro Val Pro Glu Leu Met Pro Phe Arg Leu Thr Arg Gln Phe Ile
        3955                3960                3965

 aat ctg atg tta cca atg aaa gaa acg ggc ctt atg tac agc atc atg    11952
 Asn Leu Met Leu Pro Met Lys Glu Thr Gly Leu Met Tyr Ser Ile Met
    3970                3975                3980

 gta cac gca ctc cgg gcc ttc cgc tca gac cct ggc ctg ctc acc aac    12000
 Val His Ala Leu Arg Ala Phe Arg Ser Asp Pro Gly Leu Leu Thr Asn
3985                3990                3995                4000

 acc atg gat gtg ttt gtc aag gag ccc tcc ttt gat tgg aaa aat ttt    12048
 Thr Met Asp Val Phe Val Lys Glu Pro Ser Phe Asp Trp Lys Asn Phe
                4005                4010                4015

 gaa cag aaa atg ctg aaa aaa gga ggg tca tgg att caa gaa ata aat    12096
 Glu Gln Lys Met Leu Lys Lys Gly Gly Ser Trp Ile Gln Glu Ile Asn
            4020                4025                4030

 gtt gct gaa aaa aat tgg tac ccc cga cag aaa ata tgt tac gct aag    12144
 Val Ala Glu Lys Asn Trp Tyr Pro Arg Gln Lys Ile Cys Tyr Ala Lys
        4035                4040                4045

 aga aag tta gca ggt gcc aat cca gca gtc att act tgt gat gag cta    12192
 Arg Lys Leu Ala Gly Ala Asn Pro Ala Val Ile Thr Cys Asp Glu Leu
    4050                4055                4060

 ctc ctg ggt cat gag aag gcc cct gcc ttc aga gac tat gtg gct gtg    12240
 Leu Leu Gly His Glu Lys Ala Pro Ala Phe Arg Asp Tyr Val Ala Val
4065                4070                4075                4080

 gca cga gga agc aaa gat cac aac att cgt gcc caa gaa cca gag agt    12288
 Ala Arg Gly Ser Lys Asp His Asn Ile Arg Ala Gln Glu Pro Glu Ser
                4085                4090                4095

 ggg ctt tca gaa gag act caa gtg aag tgc ctg atg gac cag gca aca    12336
 Gly Leu Ser Glu Glu Thr Gln Val Lys Cys Leu Met Asp Gln Ala Thr
            4100                4105                4110

 gac ccc aac atc ctt ggc aga acc tgg gaa gga tgg gag ccc tgg atg    12384
 Asp Pro Asn Ile Leu Gly Arg Thr Trp Glu Gly Trp Glu Pro Trp Met
        4115                4120                4125

 tga ggtc tgtgggagtc tgcagataga aagcattaca ttgtttaaag aatctactat    12441
 


 actttggttg gcagcattcc atgagctgat tttcctgaaa cactaaagag aaatgtcttt  12501

 tgtgctacag tttcgtagca tgagtttaaa tcaagattat gatgagtaaa tgtgtatggg  12561

 ttaaatcaaa gataaggtta tagtaacatc aaagattagg tgaggtttat agaaagatag  12621

 atatccaggc ttaccaaagt attaagtcaa gaatataata tgtgatcagc tttcaaagca  12681

 tttacaagtg ctgcaagtta gtgaaacagc tgtctccgta aatggaggaa atgtggggaa  12741

 gccttggaat gcccttctgg ttctggcaca ttggaaagca cactcagaag gcttcatcac  12801

 caagattttg ggagagtaaa gctaagtata gttgatgtaa cattgtagaa gcagcatagg  12861

 aacaataaga acaataggta aagctataat tatggcttat atttagaaat gactgcattt  12921

 gatattttag gatatttttc taggtttttt cctttcattt tattctcttc tagttttgac  12981

 attttatgat agatttgctc tctagaagga aacgtcttta tttaggaggg caaaaatttt  13041

 ggtcatagca ttcacttttg ctattccaat ctacaactgg aagatacata aaagtgcttt  13101

 gcattgaatt tgggataact tcaaaaatcc catggttgtt gttagggata gtactaagca  13161

 tttcagttcc aggagaataa aagaaattcc tatttgaaat gaattcctca tttggaggaa  13221

 aaaaagcatg cattctagca caacaagatg aaattatgga atacaaaagt ggctccttcc  13281

 catgtgcagt ccctgtcccc ccccgccagt cctccacacc caaactgttt ctgattggct  13341

 tttagctttt tgttgttttt ttttttcctt ctaacacttg tatttggagg ctcttctgtg  13401

 attttgagaa gtatactctt gagtgtttaa taaagttttt ttccaaaagt aaaaaaaaaa  13461

 aaaaaaa                                                            13468




      <210> 172
      <211> 412
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (45)..(122)

      <400> 172
 aggactttcg cacgaggcgc catcttcctt gagactcctg cgcc atg aga gcg aag      56
                                                  Met Arg Ala Lys
                                                    1

 tgg cgg aag aag aga atg cgc agg ctg aag cgc aag aga aga aag atg      104
 Trp Arg Lys Lys Arg Met Arg Arg Leu Lys Arg Lys Arg Arg Lys Met
   5                  10                  15                  20

 agg cag agg tcc aag taa accatc ttgtgcaccc acgaagcctg cgggagcaga      158
 Arg Gln Arg Ser Lys 
                  25

 agtaagggat gctgaagccc ggaacaagtg gttggactgt atgctgctgt cggtaataag    218

 tctcagtaga cccggaatgt cacctcgccg agatcagctg ggaaaatgac taccttcctc    278

 acaaccaaaa cagtcccgct ggccctctgc cctggacctt tggcattctg gactagttct    338

 gttctcttgt ggccaagtgt aactcgtgta caataaaccc tcttgctgtc agctgaagaa    398

 tcaaaaaaaa aaaa                                                      412




      <210> 173
      <211> 1706
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (15)..(1295)

      <400> 173
 caggttgtaa atcc  atg tgg cgg ggg ctt tgg acc ctg gcg gcc caa gcg      50
                  Met Trp Arg Gly Leu Trp Thr Leu Ala Ala Gln Ala
                    1               5                  10

 gca cgt ggg cct cgc aga ttg tgc acg cgc cgg agc agc ggc gca cca       98
 Ala Arg Gly Pro Arg Arg Leu Cys Thr Arg Arg Ser Ser Gly Ala Pro
          15                  20                  25

 gcc ccc ggc tcc ggc gcc acc atc ttc gcg cta agc tct ggc caa ggc      146
 Ala Pro Gly Ser Gly Ala Thr Ile Phe Ala Leu Ser Ser Gly Gln Gly
      30                  35                  40

 cgc tgc ggc atc gca gtg atc cgg acc agc ggc ccc gcc agc ggc cac      194
 Arg Cys Gly Ile Ala Val Ile Arg Thr Ser Gly Pro Ala Ser Gly His
  45                  50                  55                  60

 gcc ctc cga att ctc aca gca ccc cga gac ctg ccc ctt gct cgc cac      242
 Ala Leu Arg Ile Leu Thr Ala Pro Arg Asp Leu Pro Leu Ala Arg His
                  65                  70                  75

 gcc agc ctg cgc ctg ctc agc gat ccc cgc tcc ggg gag cct ctg gac      290
 Ala Ser Leu Arg Leu Leu Ser Asp Pro Arg Ser Gly Glu Pro Leu Asp
              80                  85                  90

 cgc gca ctg gtg ctc tgg ttc cca ggt ccc cag agt ttc acc ggt gag      338
 Arg Ala Leu Val Leu Trp Phe Pro Gly Pro Gln Ser Phe Thr Gly Glu
          95                 100                 105

 gac tgc gtg gag ttc cac gtg cat gga ggc ccg gca gtg gtg agc ggc      386
 Asp Cys Val Glu Phe His Val His Gly Gly Pro Ala Val Val Ser Gly
     110                 115                 120

 gtc ctg cag gcc ttg ggt gag ttg cag cgt tgg gct ctg gcc cac gtg      434
 Val Leu Gln Ala Leu Gly Glu Leu Gln Arg Trp Ala Leu Ala His Val
 125                 130                 135                 140

 gag gcc tat atc gat ttc ggc gag gat gac aac ctg gag gag ggg ccg      482
 Glu Ala Tyr Ile Asp Phe Gly Glu Asp Asp Asn Leu Glu Glu Gly Pro
                 145                 150                 155

 aca tcg aag tac ggg cac tgc agg tgg ccc ctg ggt gca cat cta cga      530
 Thr Ser Lys Tyr Gly His Cys Arg Trp Pro Leu Gly Ala His Leu Arg
             160                 165                 170

 gat gcc agg cgc ggg cag agg ctc cgc tca ggg gtg cac gta gtg gtc      578
 Asp Ala Arg Arg Gly Gln Arg Leu Arg Ser Gly Val His Val Val Val
         175                 180                 185

 act gga ccc ccc aat gcg ggc aag agc agc cta gtg aac ctg ctc agt      626
 Thr Gly Pro Pro Asn Ala Gly Lys Ser Ser Leu Val Asn Leu Leu Ser
     190                 195                 200

 cgg aag cct gtg tcc atc gtg tcc ccg gag cca ggg acc acc cgt gac      674
 Arg Lys Pro Val Ser Ile Val Ser Pro Glu Pro Gly Thr Thr Arg Asp
 205                 210                 215                 220

 gtg ctg gag acc cca gtc gac ctg gcc gga ttt cct gtg ctg ctg agc      722
 Val Leu Glu Thr Pro Val Asp Leu Ala Gly Phe Pro Val Leu Leu Ser
                 225                 230                 235

 gac acg gct ggg ttg cgg gag ggc gtg ggg ccc gtg gag cag gag ggc      770
 Asp Thr Ala Gly Leu Arg Glu Gly Val Gly Pro Val Glu Gln Glu Gly
             240                 245                 250

 gtg cgg cgc gcc cgg gag agg cta gag cag gct gac ctc att ctg gcc      818
 Val Arg Arg Ala Arg Glu Arg Leu Glu Gln Ala Asp Leu Ile Leu Ala
         255                 260                 265

 atg ctg gat gct tct gac ctg gcc tct ccc tcc agt tgc aac ttc ctg      866
 Met Leu Asp Ala Ser Asp Leu Ala Ser Pro Ser Ser Cys Asn Phe Leu
     270                 275                 280

 gcc acc gtc gta gcc tct gtg gga gcc cag agc ccc agt gac agc agc      914
 Ala Thr Val Val Ala Ser Val Gly Ala Gln Ser Pro Ser Asp Ser Ser
 285                 290                 295                 300

 cag cgc ctc ctc ctg gtg ctg aac aag tcg gac ctg ctg tcc ccg gag      962
 Gln Arg Leu Leu Leu Val Leu Asn Lys Ser Asp Leu Leu Ser Pro Glu
                 305                 310                 315

 ggc cca ggt ccc ggt cct gac ctg ccc ccg cac ctg ctg ctg tcc tgt     1010
 Gly Pro Gly Pro Gly Pro Asp Leu Pro Pro His Leu Leu Leu Ser Cys
             320                 325                 330

 ctg acg gga gag ggg ctg gac ggc ctc ctg gag gcg ctg agg aag gag     1058
 Leu Thr Gly Glu Gly Leu Asp Gly Leu Leu Glu Ala Leu Arg Lys Glu
         335                 340                 345

 cta gct gca gtg tgt ggg gac ccg tcc aca gat ccc ccg ctg ctg acc     1106
 Leu Ala Ala Val Cys Gly Asp Pro Ser Thr Asp Pro Pro Leu Leu Thr
     350                 355                 360

 cga gca agg cac cag cac cac ctc cag ggt tgc ctg gat gcc ctc ggc     1154
 Arg Ala Arg His Gln His His Leu Gln Gly Cys Leu Asp Ala Leu Gly
 365                 370                 375                 380

 cac tac aag cag tca aaa gac ctg gcc ctg gcg gca gag gcg ctg cgg     1202
 His Tyr Lys Gln Ser Lys Asp Leu Ala Leu Ala Ala Glu Ala Leu Arg
                 385                 390                 395

 gtg gcc cgg ggt cac ctg acc cgg ctc aca ggt gga ggg ggt acc gag     1250
 Val Ala Arg Gly His Leu Thr Arg Leu Thr Gly Gly Gly Gly Thr Glu
             400                 405                 410

 gag atc ctg gac atc atc ttc cag gac ttc tgt gtg ggc aag tga cgg     1298
 Glu Ile Leu Asp Ile Ile Phe Gln Asp Phe Cys Val Gly Lys 
         415                 420                 425

 gatccaggga agtcgcaccc aagctgcgtg gagacccagg agcctcgggg gatctggaaa   1358

 cagtttaggc caattgggat tctcattcgc ctgggaaaga acttgattct caaatagtga   1418

 agcaacacag ctgagaggta gtgagatccc tgcagggact ccctggagat tcaggccctg   1478

 gaatggggct gaatggaggt cccgttcgac ccttgatgct ggggcatccg ggttgggatg   1538

 gagataggag gatctcagta tatttgtttc gtagtttttt atttattttg caaataccaa   1598

 aggaatgtaa aaaaaactca ggtgatctag aagtgtttat tttcttccct tcccttccct   1658

 tccctttcct tttccctttc cctttcccct tccccttccc cttcccca                1706




      <210> 174
      <211> 918
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (116)..(766)

      <400> 174
 caacatggtg agtcttactg ttgcgggctc cggggccgtc gaccatgccg ctcgacctcc     60

 acctccgctg ggaagctgag gcgccgaacg gctcccagag ggtcccggga agcgc atg     118
                                                              Met
                                                                1

 gtg ttc agg cgc ttc gtg gag gtt ggc cgg gtg gcc tat gtc tcc ttt      166
 Val Phe Arg Arg Phe Val Glu Val Gly Arg Val Ala Tyr Val Ser Phe
               5                  10                  15

 gga cct cat gcc gga aaa ttg gtc gcg att gta gat gtt att gat cag      214
 Gly Pro His Ala Gly Lys Leu Val Ala Ile Val Asp Val Ile Asp Gln
          20                  25                  30

 aac agg gct ttg gtc gat gga cct tgc act caa gtg agg aga cag gcc      262
 Asn Arg Ala Leu Val Asp Gly Pro Cys Thr Gln Val Arg Arg Gln Ala
      35                  40                  45

 atg cct ttc aag tgc atg cag ctc act gat ttc atc ctc aag ttt ccg      310
 Met Pro Phe Lys Cys Met Gln Leu Thr Asp Phe Ile Leu Lys Phe Pro
  50                  55                  60                  65

 cac agt gcc cac cag aag tat gtc cga caa gcc tgg cag aag gca gac      358
 His Ser Ala His Gln Lys Tyr Val Arg Gln Ala Trp Gln Lys Ala Asp
                  70                  75                  80

 atc aat aca aaa tgg gca gcc aca cga tgg gcc aag aag att gaa gcc      406
 Ile Asn Thr Lys Trp Ala Ala Thr Arg Trp Ala Lys Lys Ile Glu Ala
              85                  90                  95

 aga gaa agg aaa gcc aag atg aca gat ttt gat cgt ttt aaa gtt atg      454
 Arg Glu Arg Lys Ala Lys Met Thr Asp Phe Asp Arg Phe Lys Val Met
         100                 105                 110

 aag gca aag aaa atg agg aac aga ata atc aag aat gaa gtt aag aag      502
 Lys Ala Lys Lys Met Arg Asn Arg Ile Ile Lys Asn Glu Val Lys Lys
     115                 120                 125

 ctt caa aag gca gct ctc ctg aaa gct tct ccc aaa aaa gca cct ggt      550
 Leu Gln Lys Ala Ala Leu Leu Lys Ala Ser Pro Lys Lys Ala Pro Gly
 130                 135                 140                 145

 act aag ggt act gct gct gct gct gct gct gct gct gct gct gct aaa      598
 Thr Lys Gly Thr Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Lys
                 150                 155                 160

 gtt cca gca aaa aag atc acc gcc gcg agt aaa aag gct cca gcc cag      646
 Val Pro Ala Lys Lys Ile Thr Ala Ala Ser Lys Lys Ala Pro Ala Gln
             165                 170                 175

 aag gtt cct gcc cag aaa gcc aca ggc cag aaa gca gcg cct gct cca      694
 Lys Val Pro Ala Gln Lys Ala Thr Gly Gln Lys Ala Ala Pro Ala Pro
         180                 185                 190

 aaa gct cag aag ggt caa aaa gct cca gcc cag aaa gca cct gct cca      742
 Lys Ala Gln Lys Gly Gln Lys Ala Pro Ala Gln Lys Ala Pro Ala Pro
     195                 200                 205

 aag gca tct ggc aag aaa gca taa gtggcaatca taaaaagtaa taaaggttct     796
 Lys Ala Ser Gly Lys Lys Ala 
 210                 215

 ttttgacctg ttgaaaaatg tatttaagcc tttggattta aagcctgttg aggctagagt    856

 taggaggcag attgatagta ggattataat aaacattaaa taatcagaaa aaaaaaaaaa    916

 aa                                                                   918




      <210> 175
      <211> 1503
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1503)

      <400> 175
  atg atg tcc atc gat ggg gaa cag tgg tcc ttt gga att ctc ctg gct      48
  Met Met Ser Ile Asp Gly Glu Gln Trp Ser Phe Gly Ile Leu Leu Ala
    1               5                  10                  15

 gtg cac atc gat gca ctg ctg tgc cac acc gtg ccc gag ccc agg tcg       96
 Val His Ile Asp Ala Leu Leu Cys His Thr Val Pro Glu Pro Arg Ser
              20                  25                  30

 cct ttt gct ctt ggt gcc aac aag gac tca ctc tcg gcc ttc gag tac      144
 Pro Phe Ala Leu Gly Ala Asn Lys Asp Ser Leu Ser Ala Phe Glu Tyr
          35                  40                  45

 ccg ggg ccc aag cgg aag ctc tac agt gcc gtg ccc ggg agg ctc ttc      192
 Pro Gly Pro Lys Arg Lys Leu Tyr Ser Ala Val Pro Gly Arg Leu Phe
      50                  55                  60

 gtc gct gtc aag cca tac caa ccc caa gtg gac ggc gag atc ccc ctt      240
 Val Ala Val Lys Pro Tyr Gln Pro Gln Val Asp Gly Glu Ile Pro Leu
  65                  70                  75                  80

 cac cgc ggt gac agg gtc aaa ggt cag tgt ctg ctg gtt gtc ctc cgc      288
 His Arg Gly Asp Arg Val Lys Gly Gln Cys Leu Leu Val Val Leu Arg
                  85                  90                  95

 tcc tgg agt gag cac act gga acc cag cag cac ctc ctc aaa cat gac      336
 Ser Trp Ser Glu His Thr Gly Thr Gln Gln His Leu Leu Lys His Asp
             100                 105                 110

 cag act gga acc cgc ccc tcg cag gag cgt ggg gcg tgc ggg gag ctg      384
 Gln Thr Gly Thr Arg Pro Ser Gln Glu Arg Gly Ala Cys Gly Glu Leu
         115                 120                 125

 ggc ctg tct ccc agg gag aac aga aat gac aga gct cgg ttc caa aac      432
 Gly Leu Ser Pro Arg Glu Asn Arg Asn Asp Arg Ala Arg Phe Gln Asn
     130                 135                 140

 tca cac ttc aaa gga tcg atg gca aag gac tgc tgt tct gaa aag aga      480
 Ser His Phe Lys Gly Ser Met Ala Lys Asp Cys Cys Ser Glu Lys Arg
 145                 150                 155                 160

 ttc gag tgg gcc gcg cag gcc att tgc aca caa ttg gca cgg agc ccc      528
 Phe Glu Trp Ala Ala Gln Ala Ile Cys Thr Gln Leu Ala Arg Ser Pro
                 165                 170                 175

 ttc ctg ctg cca gtg gca ccg ctc ttc ctt cct gcc gag ctg tcg gtg      576
 Phe Leu Leu Pro Val Ala Pro Leu Phe Leu Pro Ala Glu Leu Ser Val
             180                 185                 190

 cct cct ccc cat cga cca aga aga ggc cct gcc cca tct aaa cca gag      624
 Pro Pro Pro His Arg Pro Arg Arg Gly Pro Ala Pro Ser Lys Pro Glu
         195                 200                 205

 aaa aac cca gaa cct ctg gac ggg agc cac gca gca gca ctc aca gct      672
 Lys Asn Pro Glu Pro Leu Asp Gly Ser His Ala Ala Ala Leu Thr Ala
     210                 215                 220

 ggc cca gaa agg acc ctc agc ggc cac cgt ccg aaa tcc aca ctt ggg      720
 Gly Pro Glu Arg Thr Leu Ser Gly His Arg Pro Lys Ser Thr Leu Gly
 225                 230                 235                 240

 gtt att gca gga gac gag ctc acc cct gag ccc cag gta gat ggt tcg      768
 Val Ile Ala Gly Asp Glu Leu Thr Pro Glu Pro Gln Val Asp Gly Ser
                 245                 250                 255

 cat tct cct gcc atc tgc aca cag gcc cgg ccc ttc acc ctc caa gcc      816
 His Ser Pro Ala Ile Cys Thr Gln Ala Arg Pro Phe Thr Leu Gln Ala
             260                 265                 270

 acg gag acc cag aaa cct gcc acc gac cag ggg tcc tgc gtg gag ggc      864
 Thr Glu Thr Gln Lys Pro Ala Thr Asp Gln Gly Ser Cys Val Glu Gly
         275                 280                 285

 cta caa cga ccc tgg agg ctt gtg ccg gcc aca ttc cta ctg aat gca      912
 Leu Gln Arg Pro Trp Arg Leu Val Pro Ala Thr Phe Leu Leu Asn Ala
     290                 295                 300

 gat gag gtt tta ttt caa atg gat ttc att ctg gaa gag gga gag att      960
 Asp Glu Val Leu Phe Gln Met Asp Phe Ile Leu Glu Glu Gly Glu Ile
 305                 310                 315                 320

 gga ggg gaa gaa ctt cca ggg tgg agc cac ccg agc tcg tgt ttg aag     1008
 Gly Gly Glu Glu Leu Pro Gly Trp Ser His Pro Ser Ser Cys Leu Lys
                 325                 330                 335

 cac aaa gga gag ggg ctt ggt gca cgc aac acc gtg ggg aca cct ttg     1056
 His Lys Gly Glu Gly Leu Gly Ala Arg Asn Thr Val Gly Thr Pro Leu
             340                 345                 350

 ggg aca agt ctc agc tct gtg agc ccg gag aag tcc cgt gag ctc tct     1104
 Gly Thr Ser Leu Ser Ser Val Ser Pro Glu Lys Ser Arg Glu Leu Ser
         355                 360                 365

 gtg cct ctg ttt cct agt ctg ttt aat ggg gat att aat ggt gcc act     1152
 Val Pro Leu Phe Pro Ser Leu Phe Asn Gly Asp Ile Asn Gly Ala Thr
     370                 375                 380

 tca cag gag agt cat aag gat aaa gat cga ggg agg ccc gtg gaa aat     1200
 Ser Gln Glu Ser His Lys Asp Lys Asp Arg Gly Arg Pro Val Glu Asn
 385                 390                 395                 400

 cgg ggt gag ggc act gag gag cgg gcg tcg gaa cct ccc aca ggg tct     1248
 Arg Gly Glu Gly Thr Glu Glu Arg Ala Ser Glu Pro Pro Thr Gly Ser
                 405                 410                 415

 ctc tcc ctg gtt gga gag ctg aaa ggg gct ggg ggt gta act cca aga     1296
 Leu Ser Leu Val Gly Glu Leu Lys Gly Ala Gly Gly Val Thr Pro Arg
             420                 425                 430

 gat act act cac cgg ttt tct gac cct gaa ttg agc ttt agg gcc aag     1344
 Asp Thr Thr His Arg Phe Ser Asp Pro Glu Leu Ser Phe Arg Ala Lys
         435                 440                 445

 aac atg gct att ttg ggg ggc agc ggg gag gag ctc tgg agg gtg aag     1392
 Asn Met Ala Ile Leu Gly Gly Ser Gly Glu Glu Leu Trp Arg Val Lys
     450                 455                 460

 gct cct cac cgc ctg ggc att tgg tgc cag act gca gat gcc agg acc     1440
 Ala Pro His Arg Leu Gly Ile Trp Cys Gln Thr Ala Asp Ala Arg Thr
 465                 470                 475                 480

 aca cag aaa gaa cca ctg cag ctg ccc aac gcc tgg gtg tct cag gac     1488
 Thr Gln Lys Glu Pro Leu Gln Leu Pro Asn Ala Trp Val Ser Gln Asp
                 485                 490                 495

 aca ttc aag cac tag                                                 1503
 Thr Phe Lys His 
             500





      <210> 176
      <211> 2043
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (118)..(2043)

      <400> 176
 gtaccggtcc ggaattcccg ggtcgacgat ttcgtggggt ccccacagac ctgcaggttc     60

 cggcccctct tttctcaacc tagagcaaat tgaaacgtcc gggatttcca aagactc       117                                                                 
 atg tta cgt gag gaa gcc acc aag aag agc aaa gaa aag gag cca ggg      165
 Met Leu Arg Glu Glu Ala Thr Lys Lys Ser Lys Glu Lys Glu Pro Gly
   1               5                  10                  15

 atg gct ctt cct cag gga cgt ttg act ttc agg gat gtg gct ata gag      213
 Met Ala Leu Pro Gln Gly Arg Leu Thr Phe Arg Asp Val Ala Ile Glu
              20                  25                  30

 ttc tct ttg gag gag tgg aaa tgc ctg aac cct gca cag agg gct tta      261
 Phe Ser Leu Glu Glu Trp Lys Cys Leu Asn Pro Ala Gln Arg Ala Leu
          35                  40                  45

 tac agg gct gtg atg ttg gag aac tac agg aac ctg gag ttt gtg gat      309
 Tyr Arg Ala Val Met Leu Glu Asn Tyr Arg Asn Leu Glu Phe Val Asp
      50                  55                  60

 agc tct tta aaa tcc atg acg gag ttc tca tca aca ggg cac ggt aat      357
 Ser Ser Leu Lys Ser Met Thr Glu Phe Ser Ser Thr Gly His Gly Asn
  65                  70                  75                  80

 aca gga gaa gtg atc cac aca ggg aca ttg caa aga cat aaa agt cat      405
 Thr Gly Glu Val Ile His Thr Gly Thr Leu Gln Arg His Lys Ser His
                  85                  90                  95

 cac att gga gat ttt tgc ttc cca gaa atc aag aaa gat att cat gac      453
 His Ile Gly Asp Phe Cys Phe Pro Glu Ile Lys Lys Asp Ile His Asp
             100                 105                 110

 ttt gag ttt cag tgg caa gaa att aaa aga aat ggc cat gaa gca ccc      501
 Phe Glu Phe Gln Trp Gln Glu Ile Lys Arg Asn Gly His Glu Ala Pro
         115                 120                 125

 atg aca aaa atc aaa aag ttg act ggt agt aca gac cga cgt gat caa      549
 Met Thr Lys Ile Lys Lys Leu Thr Gly Ser Thr Asp Arg Arg Asp Gln
     130                 135                 140

 agg cat gct gga aac aag cct att aaa gat cag ctt gga tca agc ttt      597
 Arg His Ala Gly Asn Lys Pro Ile Lys Asp Gln Leu Gly Ser Ser Phe
 145                 150                 155                 160

 tat tca cat ctg cct gaa ctg cac gaa ttt cag act gaa ggg aaa att      645
 Tyr Ser His Leu Pro Glu Leu His Glu Phe Gln Thr Glu Gly Lys Ile
                 165                 170                 175

 gat aat caa gtg gag aag tct atc aac aat gct tcc ttg gtt tca aca      693
 Asp Asn Gln Val Glu Lys Ser Ile Asn Asn Ala Ser Leu Val Ser Thr
             180                 185                 190

 tcc caa aga att tct tgt agg ctc aaa acc cat att tct aat agg tat      741
 Ser Gln Arg Ile Ser Cys Arg Leu Lys Thr His Ile Ser Asn Arg Tyr
         195                 200                 205

 ggg aag aac ttt ctc cat tct tca tta ttg aca caa atc cag gaa gaa      789
 Gly Lys Asn Phe Leu His Ser Ser Leu Leu Thr Gln Ile Gln Glu Glu
     210                 215                 220

 cac gtg aga gaa aaa cct ttc caa tgt aat gag tgt ggc aaa gcc ttt      837
 His Val Arg Glu Lys Pro Phe Gln Cys Asn Glu Cys Gly Lys Ala Phe
 225                 230                 235                 240

 aat tat agc tca cat tta aga aga cat cat gta acc cat tca gga gag      885
 Asn Tyr Ser Ser His Leu Arg Arg His His Val Thr His Ser Gly Glu
                 245                 250                 255

 aaa caa tat aaa tgt gat gta tgt ggc aaa gtg ttt cat caa aag caa      933
 Lys Gln Tyr Lys Cys Asp Val Cys Gly Lys Val Phe His Gln Lys Gln
             260                 265                 270

 tac ctt gca tgg cac cat aga gtt cat act gga gaa aaa cct tac aag      981
 Tyr Leu Ala Trp His His Arg Val His Thr Gly Glu Lys Pro Tyr Lys
         275                 280                 285

 tgt aat gag tgt tcc aag acc ttc ggt cac aag tca tcc ctt aca cgc     1029
 Cys Asn Glu Cys Ser Lys Thr Phe Gly His Lys Ser Ser Leu Thr Arg
     290                 295                 300

 cat cat aga ctt cat act gga gaa aaa cct tac aag tgt aat gag tgt     1077
 His His Arg Leu His Thr Gly Glu Lys Pro Tyr Lys Cys Asn Glu Cys
 305                 310                 315                 320

 ggt aag acc ttc agt cag acg tca tcc ctt gta ggg cat cgt aga cgt     1125
 Gly Lys Thr Phe Ser Gln Thr Ser Ser Leu Val Gly His Arg Arg Arg
                 325                 330                 335

 cat act gga gag aaa cct tac aaa tgt gaa gga tgt gac aaa gtt tac     1173
 His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Gly Cys Asp Lys Val Tyr
             340                 345                 350

 agt tgc aga tca caa ctt gaa aca cat agg cga att cat act gga gag     1221
 Ser Cys Arg Ser Gln Leu Glu Thr His Arg Arg Ile His Thr Gly Glu
         355                 360                 365

 aaa cca tac aaa tgt aag gtt tgt gac aaa gct ttt agg cat aat tca     1269
 Lys Pro Tyr Lys Cys Lys Val Cys Asp Lys Ala Phe Arg His Asn Ser
     370                 375                 380

 tgc ctt tca cgc cat aac aga gtt cat act gaa gag aaa cct tac aca     1317
 Cys Leu Ser Arg His Asn Arg Val His Thr Glu Glu Lys Pro Tyr Thr
 385                 390                 395                 400

 tgt aat gaa tgt ggc aag gtt ttc cag cgt gat tca tac ctt gca caa     1365
 Cys Asn Glu Cys Gly Lys Val Phe Gln Arg Asp Ser Tyr Leu Ala Gln
                 405                 410                 415

 cat cag aga gtt cat act gga gag aaa cct tac aca tgt aat gaa tgt     1413
 His Gln Arg Val His Thr Gly Glu Lys Pro Tyr Thr Cys Asn Glu Cys
             420                 425                 430

 ggt aag gtt ttt aat caa aaa gca cac ctt gca tgt cat tat agg ctt     1461
 Gly Lys Val Phe Asn Gln Lys Ala His Leu Ala Cys His Tyr Arg Leu
         435                 440                 445

 cat act gga gag aaa cct tac aag tgt aat gag tgt ggc aag acc ttc     1509
 His Thr Gly Glu Lys Pro Tyr Lys Cys Asn Glu Cys Gly Lys Thr Phe
     450                 455                 460

 agt cag aag tca tcc ctt gtg ggc cat cgt aga ctt cat acc gga gaa     1557
 Ser Gln Lys Ser Ser Leu Val Gly His Arg Arg Leu His Thr Gly Glu
 465                 470                 475                 480

 aaa cct tac aac tgt cat gag tgt ggc aag acc ttt gct cga aat tca     1605
 Lys Pro Tyr Asn Cys His Glu Cys Gly Lys Thr Phe Ala Arg Asn Ser
                 485                 490                 495

 tcc ctt cta att cat aag gca att cat act gga gag aaa cct tac aag     1653
 Ser Leu Leu Ile His Lys Ala Ile His Thr Gly Glu Lys Pro Tyr Lys
             500                 505                 510

 tgt aat gaa tgt ggc aag gtt ttt aat caa cag tca aac ctt gca caa     1701
 Cys Asn Glu Cys Gly Lys Val Phe Asn Gln Gln Ser Asn Leu Ala Gln
         515                 520                 525

 cat cag aga gtt cat act gga gag aaa cct tac agg tgt aat gag tgt     1749
 His Gln Arg Val His Thr Gly Glu Lys Pro Tyr Arg Cys Asn Glu Cys
     530                 535                 540

 ggc aag acc ttc agt cat atg tca tcc ttt gta tac cat tat aga ctt     1797
 Gly Lys Thr Phe Ser His Met Ser Ser Phe Val Tyr His Tyr Arg Leu
 545                 550                 555                 560

 cat agt gga gag aaa cct tac aag tgc aat gag tgt ggc aag acc ttc     1845
 His Ser Gly Glu Lys Pro Tyr Lys Cys Asn Glu Cys Gly Lys Thr Phe
                 565                 570                 575

 agt cat atg tca tcc ttt gta tgc cat cat aga ctt cat act gga gaa     1893
 Ser His Met Ser Ser Phe Val Cys His His Arg Leu His Thr Gly Glu
             580                 585                 590

 aat cct tat aag tgc aat gag tgt ggc aaa gcc ttt agt ggg cag tca     1941
 Asn Pro Tyr Lys Cys Asn Glu Cys Gly Lys Ala Phe Ser Gly Gln Ser
         595                 600                 605

 tca ctt att cat cat caa gca atc cat ggt ata ggg aaa ctt tac aaa     1989
 Ser Leu Ile His His Gln Ala Ile His Gly Ile Gly Lys Leu Tyr Lys
     610                 615                 620

 tgt aat gat tct cac aaa gtc ctc agt aat gct aca agc att gca aat     2037
 Cys Asn Asp Ser His Lys Val Leu Ser Asn Ala Thr Ser Ile Ala Asn
 625                 630                 635                 640

 cat tag                                                             2043
 His 






      <210> 177
      <211> 1119
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (118)..(603)

      <400> 177
 gggggtgggg gcgggtggtt gcctgcggga ggccgccgcg ggtcatgtga ccggaagggc     60

 tcctcacgga cgccgtccct cctcggcgcg gcctgagcgc ccggcccgac cccggcc       117                                                                 
 atg ggg tgc tgc tac agc agc gag aac gag gac tcg gac cag gac cga      165
 Met Gly Cys Cys Tyr Ser Ser Glu Asn Glu Asp Ser Asp Gln Asp Arg
   1               5                  10                  15

 gag gag cgg aag ctg ctg ctg gac cct agc agc ccc cct acc aaa gct      213
 Glu Glu Arg Lys Leu Leu Leu Asp Pro Ser Ser Pro Pro Thr Lys Ala
              20                  25                  30

 ctc aat gga gcc gag ccc aac tac cac agc ctg cct tcc gct cgc act      261
 Leu Asn Gly Ala Glu Pro Asn Tyr His Ser Leu Pro Ser Ala Arg Thr
          35                  40                  45

 gat gag cag gcc ctg ctc tct tcc atc ctt gcc aag aca gcc agc aac      309
 Asp Glu Gln Ala Leu Leu Ser Ser Ile Leu Ala Lys Thr Ala Ser Asn
      50                  55                  60

 atc att gat gtg tct gct gca gac tca cag ggc atg gag cag cat gag      357
 Ile Ile Asp Val Ser Ala Ala Asp Ser Gln Gly Met Glu Gln His Glu
  65                  70                  75                  80

 tac atg gac cgt gcc agg cag tac agc acc cgc ttg gct gtg ctg agc      405
 Tyr Met Asp Arg Ala Arg Gln Tyr Ser Thr Arg Leu Ala Val Leu Ser
                  85                  90                  95

 agc agc ctg acc cat tgg aag aag ctg cca ccg ctg ccg tct ctt acc      453
 Ser Ser Leu Thr His Trp Lys Lys Leu Pro Pro Leu Pro Ser Leu Thr
             100                 105                 110

 agc cag ccc cac caa gtg ctg gcc agt gag ccc atc ccg ttc tct gat      501
 Ser Gln Pro His Gln Val Leu Ala Ser Glu Pro Ile Pro Phe Ser Asp
         115                 120                 125

 ttg cag cag gtc tcc agg ata gct gct tat gcc tac agt gca ctt tct      549
 Leu Gln Gln Val Ser Arg Ile Ala Ala Tyr Ala Tyr Ser Ala Leu Ser
     130                 135                 140

 cag atc cgt gtg gac gca aaa gag gag ctg gtt gta cag ttt ggg atc      597
 Gln Ile Arg Val Asp Ala Lys Glu Glu Leu Val Val Gln Phe Gly Ile
 145                 150                 155                 160

 cca tga agagaggggt ccttggacag ctcttctcct ctcttcatcc catctctacc       653
 Pro 


 ccaccccctt ggcccccagc ctcactgcgg cttatacagt accctaacct gctactaatc    713

 acagagaaaa atgtgaagaa ggaggagaag aggaaggcta gaagcctgag caagtgaggg    773

 tagaaccttt tgggactggc ctttgaagct ctggccaggg atggggtggg ggccaaaagg    833

 acagatcctg gtatgtcttc atagtcattg agaatgtgga gatccccttt tgggtgctgg    893

 gtgatcacca ggggaaccta gggagatccc cttcccaccc tcgtctgttc ggcctcacga    953

 gtcactccta gccccctact cccatgactt cggtgcttca catgcacgct cacgtagggt   1013

 atcgtgacca gggtctggga tgaacttgaa tttgaatgaa ttgagtttgt atttctagaa   1073

 ccctggggtt tcacatgttt ggtcttttgt tgttttggtt tgtcac                  1119




      <210> 178
      <211> 3697
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (267)..(1649)

      <400> 178
 cgtgcatgcg cgaccggtcc ggaattcccg ggtcgacgat ttcgtggcag ctccttatgc     60

 agcttaagcc tgtcctgtgg aacatccctg tgggagactg tgaccagacc aagcgacacg    120

 gatcctgaga gcgctcccgg gtaggcattt gccccggtgg gacacctcac cacaacagtg    180

 tgtggcaggc ccccgtggag aatcaacgca gtggctgaac accgggaagg aatgggcact    240

 tggagtctgg acatctaaaa cttgaa atg gcg gct gcg gcg gct cga gtg gtg     293
                              Met Ala Ala Ala Ala Ala Arg Val Val
                                1               5

 ttg tca tcc gcg gcg cgg cgg cgg ctc tgg ggt ttc agc gag agt ctt      341
 Leu Ser Ser Ala Ala Arg Arg Arg Leu Trp Gly Phe Ser Glu Ser Leu
  10                  15                  20                  25

 cta atc cga ggc gct gcg gga cgg tca tta tat ttt gga gag aac aga      389
 Leu Ile Arg Gly Ala Ala Gly Arg Ser Leu Tyr Phe Gly Glu Asn Arg
                  30                  35                  40

 tta aga agt aca cag gct gct acc caa gtt gtt ctg aat gtt cct gaa      437
 Leu Arg Ser Thr Gln Ala Ala Thr Gln Val Val Leu Asn Val Pro Glu
              45                  50                  55

 aca aga gta aca tgt tta gaa agt gga ctc aga gta gct tcg gaa gac      485
 Thr Arg Val Thr Cys Leu Glu Ser Gly Leu Arg Val Ala Ser Glu Asp
          60                  65                  70

 tct ggg ctc tca aca tgc aca ggc acc aag aag aga tcc cag tta gat      533
 Ser Gly Leu Ser Thr Cys Thr Gly Thr Lys Lys Arg Ser Gln Leu Asp
      75                  80                  85

 ctg gaa ctt gag att gaa aat atg ggt gct cat ctc aat gcc tat acc      581
 Leu Glu Leu Glu Ile Glu Asn Met Gly Ala His Leu Asn Ala Tyr Thr
  90                  95                 100                 105

 tcc aga gag cag act gta tac tat gcc aaa gca ttc tct aaa gac ttg      629
 Ser Arg Glu Gln Thr Val Tyr Tyr Ala Lys Ala Phe Ser Lys Asp Leu
                 110                 115                 120

 cca aga gct gta gaa att ctt gct gat ata ata caa aac agc aca ttg      677
 Pro Arg Ala Val Glu Ile Leu Ala Asp Ile Ile Gln Asn Ser Thr Leu
             125                 130                 135

 gga gaa gca gag att gaa cgt gag cgt gga gta atc ctt aga gag ata      725
 Gly Glu Ala Glu Ile Glu Arg Glu Arg Gly Val Ile Leu Arg Glu Ile
         140                 145                 150

 cag gaa gtt gaa acc aat tta caa gaa gtt gtt ttt gat tat ctt cat      773
 Gln Glu Val Glu Thr Asn Leu Gln Glu Val Val Phe Asp Tyr Leu His
     155                 160                 165

 gcc aca gct tat caa aat act gca ctt gga cgg aca att ttg gga cca      821
 Ala Thr Ala Tyr Gln Asn Thr Ala Leu Gly Arg Thr Ile Leu Gly Pro
 170                 175                 180                 185

 act gaa aat atc aaa tct ata agt cgt aag gac tta gtg gat tat ata      869
 Thr Glu Asn Ile Lys Ser Ile Ser Arg Lys Asp Leu Val Asp Tyr Ile
                 190                 195                 200

 acc aca cat tat aag ggg cca aga ata gtg ctt gct gct gct gga ggt      917
 Thr Thr His Tyr Lys Gly Pro Arg Ile Val Leu Ala Ala Ala Gly Gly
             205                 210                 215

 gtt tcc cat gat gaa ttg ctt gac tta gca aag ttt cat ttc ggt gac      965
 Val Ser His Asp Glu Leu Leu Asp Leu Ala Lys Phe His Phe Gly Asp
         220                 225                 230

 tct tta tgc aca cac aaa gga gaa ata cca gct ctg cct ccc tgc aaa     1013
 Ser Leu Cys Thr His Lys Gly Glu Ile Pro Ala Leu Pro Pro Cys Lys
     235                 240                 245

 ttc aca gga agt gag att cgt gtg agg gat gac aag atg cct ttg gcg     1061
 Phe Thr Gly Ser Glu Ile Arg Val Arg Asp Asp Lys Met Pro Leu Ala
 250                 255                 260                 265

 cac ctt gca ata gct att gct gct gtt ggt tgg gca cat cca gat aca     1109
 His Leu Ala Ile Ala Ile Ala Ala Val Gly Trp Ala His Pro Asp Thr
                 270                 275                 280

 atc tgt ctc atg gtt gca aac acg ctg att ggc aac tgg gat cgc tct     1157
 Ile Cys Leu Met Val Ala Asn Thr Leu Ile Gly Asn Trp Asp Arg Ser
             285                 290                 295

 ttt ggg gga gga atg aat tta tct agc aag ctg gcc cag ctc act tgt     1205
 Phe Gly Gly Gly Met Asn Leu Ser Ser Lys Leu Ala Gln Leu Thr Cys
         300                 305                 310

 cat ggc aat ctt tgc cat agc ttt cag tct ttc aac act tcc tac aca     1253
 His Gly Asn Leu Cys His Ser Phe Gln Ser Phe Asn Thr Ser Tyr Thr
     315                 320                 325

 gat aca gga tta tgg gga ctg tat atg gtt tgt gaa tca tcc act gtt     1301
 Asp Thr Gly Leu Trp Gly Leu Tyr Met Val Cys Glu Ser Ser Thr Val
 330                 335                 340                 345

 gca gac atg cta cat gtt gtt caa aaa gaa tgg atg cga ctc tgt aca     1349
 Ala Asp Met Leu His Val Val Gln Lys Glu Trp Met Arg Leu Cys Thr
                 350                 355                 360

 agt gtc aca gaa agt gag gtt gca cga gcc aga aat ctt ctg aaa aca     1397
 Ser Val Thr Glu Ser Glu Val Ala Arg Ala Arg Asn Leu Leu Lys Thr
             365                 370                 375

 aac atg ttg ttg cag ctt gat ggt tca act cca att tgt gaa gat att     1445
 Asn Met Leu Leu Gln Leu Asp Gly Ser Thr Pro Ile Cys Glu Asp Ile
         380                 385                 390

 ggt agg caa atg tta tgc tat aat aga agg att ccc atc cct gag ctt     1493
 Gly Arg Gln Met Leu Cys Tyr Asn Arg Arg Ile Pro Ile Pro Glu Leu
     395                 400                 405

 gaa gca aga att gat gct gtg aat gct gag aca att cga gaa gta tgt     1541
 Glu Ala Arg Ile Asp Ala Val Asn Ala Glu Thr Ile Arg Glu Val Cys
 410                 415                 420                 425

 acc aaa tac att tat aat agg agt cca gct att gct gct gtt ggt ccc     1589
 Thr Lys Tyr Ile Tyr Asn Arg Ser Pro Ala Ile Ala Ala Val Gly Pro
                 430                 435                 440

 att aag caa cta cca gat ttt aaa cag ata cgc agt aac atg tgt tgg     1637
 Ile Lys Gln Leu Pro Asp Phe Lys Gln Ile Arg Ser Asn Met Cys Trp
             445                 450                 455

 ctt cgt gat taa aat gctcctaatc aagattgttt gaacacatgt atttataaaa     1692
 Leu Arg Asp 
         460

 cagagctaga gaaaaataaa aatgaacatg tatatacatt tggaaatttg aattaaatac   1752

 tgtatcatac tttcaaagga taaaaagact acccctctga aggttgtttt gtattaatgg   1812

 tcagtctttg ttctctgaga aattatgttg gaagcagcat actttcaaat tattaccatg   1872

 agtataattt taagaatgaa aatgtttaca gtattttcag ttttattata aaaatgcaca   1932

 cacaacaaag attgtcattt cttggctcta cttgcattca gcacttgttc ttgagcagct   1992

 ttctttgctt ttaccatctc gacaagttcc ttgtatcgtt tcatgcagtc cttctttgtc   2052

 ctgccaggca ccgcttctgc tattttttcc catctttcag gtgtatttac tgggtatgtt   2112

 ttcaaagctt gttccaaaag cttctgttct tctgttgtcc aaggggtgaa gtctgtatat   2172

 ggaccttcaa atcgttctga aggcgttgcg ttgtctgctt gaggtaccac tccatgttct   2232

 tttttgaact tatcaaatgc ctttttattt atgtcatctt tttgatgagg gtcaagtttt   2292

 tggagactct ttgctttgcc aataacatct ttggcagttc ttttgactcc agaggaagaa   2352

 tgtatgttca tgtaattagc aataacttcc catcttgaat ttgttctagc agggaacaga   2412

 ttcacagctt taattagtaa ttgtagatca tcttctgacc aatttttact tccatttcca   2472

 cctccaccag ttgatttctc tgtgttctta gatgcttgtc gcatacgagc ctcagcttcc   2532

 tctttctctt ttctgatttg ctcatttatt tcttctatct tgcatgagtt tcgaagtttt   2592

 tgcctttcct tcttaatggc ttttttctgg atatcttttt ccttctttgc cagcaatgct   2652

 tgctgtctga cttcctcctc ttctttctcc ttagctaacc gagcagcttc taattcagct   2712

 tgtctttgtt tttctttagc ttcttgctcc ttccgtttag cttctgcttt tgctttcttt   2772

 tctgcttctt tcttggcttt ttcttcttcc ttgaactttt ttatccttgg atcacagctg   2832

 tatgcattgt caactaatgt tcttattctg ttcatttctt ctttttttct ttgtgctctt   2892

 gttgctccgt tctgcttttc aatccatctc ctctcatcac gacattctgc tttttctttt   2952

 tcttcttcat ctaaataaga aaattctctc caagaatcaa aattatacca gaaagaataa   3012

 aatatatcta catcttcaaa tgatgaattc atatcaccaa gtttaggaac atttttttta   3072

 tttgaccatc tggaattcct ttcaaacact ggggtaaaca cttcgaagaa attatccttt   3132

 gcttcacttt tagaaggaac tgagttatca aaagtaggat ctacactgtt aaatgctcgt   3192

 cttttcactg gatcagataa catttcataa gctttagtta tgcaagtgaa gtagtcatta   3252

 tctccttctt ttattggttc accagctgct ttccgtttgt ctgggtgatg ttttaaaacc   3312

 attgctttat gagctgcttt gatctgtctc tgtgtagcct tgtatctcac atggccaagt   3372

 ccaagaactg cataatgatc ttggttcttc cagtctttgg gatcaagtgt tttcagcatg   3432

 ggaaactctt ccaactgcaa ttcttcatct tctgattcct cggataactc tttcttatcc   3492

 tccagttcct gaaaagaggc agaagcattt ctgtttctcc tcttaacaaa agcttcaaac   3552

 catcttccca caggttcaac ttgacagagt gtagaggcag aggtcagagc gtgggtgatg   3612

 gcggtgcccc ggccgtccgc ggcgcttggc agaagcagca tgatggcgcc gggtctagcc   3672

 cggtgggcgc agcggctcac gtccc                                         3697




      <210> 179
      <211> 1071
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (763)..(1056)

      <400> 179
 acatcctggg tcgacgggag gcaggaggta tgagggcaaa agtggtgaga gaagcagatg     60

 agcttttcta ggacatgctt gctcaggaga agggaggcag agcgtataag aacatactga    120

 gcctccttgc cactttcgac gttcaaccaa tatttgttag gcactaaata tacatgcagg    180

 acacttttct gtatgttgtt tcatttaatt cttaaataat cctttacaga ctcagagagg    240

 tgaagagagt agcacaggta gtatcagaat tgggattcaa acctgacaca tacactgagc    300

 actaagttaa aaccgggcac tgggcagctg ctgaggatgc gatggtgagt acaacagact    360

 gcttgctctt tttgatatct agaatcttac agctctgctg tgctcatcct tgtctgttgt    420

 catttactag ttgacatctt cgttgactac ctagaagcag ctgcttcgac atctatccca    480

 acctgaatcc cgtcaaaggg agattacaac aaatgtgctt tttgtctatc atctctagct    540

 agtgtttcac agtgggggga gtatcatttc ctgggtgact ttgcatagag caagctcccc    600

 aaaggccaag gaatactcaa tctagattct tccaatcctc cggtacccac caagtcaaaa    660

 gaattctggc tccctgtagc ttcatctaag tgcttttctg ttagaggaga aaagtgagga    720

 aagcgatgct ctttcaataa gttcggcagg gtggggcaag ga   atg gta caa att     774
                                                  Met Val Gln Ile
                                                    1

 gat ttt ttt ttt ttc ttg aga cag agt ctc gct ctg tct ccc agg ctg      822
 Asp Phe Phe Phe Phe Leu Arg Gln Ser Leu Ala Leu Ser Pro Arg Leu
   5                  10                  15                  20

 gag tgc agt ggc ccg gtc tcg gct cac tgc gac ctc cgc ctc ccg gat      870
 Glu Cys Ser Gly Pro Val Ser Ala His Cys Asp Leu Arg Leu Pro Asp
                  25                  30                  35

 tca agc gat tct cct gcc tta gcc tcc aaa gta gcc ggg act aca ggc      918
 Ser Ser Asp Ser Pro Ala Leu Ala Ser Lys Val Ala Gly Thr Thr Gly
              40                  45                  50

 gta cgc cac cac tcc cgg cca att tct gta ttt tta gca aag acg ggg      966
 Val Arg His His Ser Arg Pro Ile Ser Val Phe Leu Ala Lys Thr Gly
          55                  60                  65

 gtt tca cca tat tgg cca ggc tgg tct cga act cat gac ctt gcg att     1014
 Val Ser Pro Tyr Trp Pro Gly Trp Ser Arg Thr His Asp Leu Ala Ile
      70                  75                  80

 cgc ccg cct cgg cct ccc aaa gtg ttg gga cca cag gcg taa gccaccg     1063
 Arg Pro Pro Arg Pro Pro Lys Val Leu Gly Pro Gln Ala 
  85                  90                  95

 cgcccgcg                                                            1071




      <210> 180
      <211> 660
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (161)..(337)

      <400> 180
 ttttaagaga caaggtctca cccaagctag agtgtatggt gcaaggaacc tgtgagctca     60

 attcatccta cctcctcagc ctcctaagta gctgagacca caggcataca tcaccacacc    120

 cagctaattt tttctgtttt tgtagagatg aggtctcact  atg ttg ccc caa ctc     175
                                              Met Leu Pro Gln Leu
                                                1               5

 ctt gcc tca agg aat cat cct atc ttg gcc ttc caa agt gat ggg att      223
 Leu Ala Ser Arg Asn His Pro Ile Leu Ala Phe Gln Ser Asp Gly Ile
                  10                  15                  20

 aca ggc atg agc cac tgt gcc cag ata gct tac tca tct tta ctg agc      271
 Thr Gly Met Ser His Cys Ala Gln Ile Ala Tyr Ser Ser Leu Leu Ser
              25                  30                  35

 agc ttc ctc ctc tgt aaa atg aaa gat aac att aat agt act tgt ctt      319
 Ser Phe Leu Leu Cys Lys Met Lys Asp Asn Ile Asn Ser Thr Cys Leu
          40                  45                  50

 gcc tac ttt acc agt tag atgtga aaagcaaata taatagaaca cagaaagcaa      373
 Ala Tyr Phe Thr Ser 
      55

 actgagggca taaagcaaac tcttagtcta tgtattccta tcatgatctt acaatagatt    433

 caaggttaca ttcaaagagg gaagatgaac caaatgtcca tcagttagga ttcttcctat    493

 agtattaata acacaagttt ctttagattc tctgcctttg ttcacagttc actgtttcat    553

 cagaggtgaa catgaatcag aattgtttgc atattccagt agagagcctg gcttagtcta    613

 tatttctata taatttaaat cgggctcgtg ccgaattccg caggcgg                  660




      <210> 181
      <211> 1471
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (114)..(980)

      <400> 181
 atttggccct cgaggcaaga attcggcacg aggcttacat aaagggacaa ttggagcctg     60

 agaggtgaca gtgctgacac tacaaggctc ggagctccgg gcactcagac atc   atg     116
                                                              Met
                                                                1

 agt tgg tcc ttg cac ccc cgg aat tta att ctc tac ttc tat gct ctt      164
 Ser Trp Ser Leu His Pro Arg Asn Leu Ile Leu Tyr Phe Tyr Ala Leu
               5                  10                  15

 tta ttt ctc tct tca aca tgt gta gca tat gtt gct acc aga gac aac      212
 Leu Phe Leu Ser Ser Thr Cys Val Ala Tyr Val Ala Thr Arg Asp Asn
          20                  25                  30

 tgc tgc atc tta gat gaa aga ttc ggt agt tat tgt cca act acc tgt      260
 Cys Cys Ile Leu Asp Glu Arg Phe Gly Ser Tyr Cys Pro Thr Thr Cys
      35                  40                  45

 ggc att gca gat ttc ctg tct act tat caa acc aaa gta gac aag gat      308
 Gly Ile Ala Asp Phe Leu Ser Thr Tyr Gln Thr Lys Val Asp Lys Asp
  50                  55                  60                  65

 cta cag tct ttg gaa gac atc tta cat caa gtt gaa aac aaa aca tca      356
 Leu Gln Ser Leu Glu Asp Ile Leu His Gln Val Glu Asn Lys Thr Ser
                  70                  75                  80

 gaa gtc aaa cag ctg ata aaa gca atc caa ctc act tat aat ctt gat      404
 Glu Val Lys Gln Leu Ile Lys Ala Ile Gln Leu Thr Tyr Asn Leu Asp
              85                  90                  95

 gaa tca tca aaa cca aat atg ata gac gct gct act ttg aag tcc agg      452
 Glu Ser Ser Lys Pro Asn Met Ile Asp Ala Ala Thr Leu Lys Ser Arg
         100                 105                 110

 aaa atg tta gaa gaa att atg aaa tat gaa gca tcg att tta aca cat      500
 Lys Met Leu Glu Glu Ile Met Lys Tyr Glu Ala Ser Ile Leu Thr His
     115                 120                 125

 gac tca agt atc cga tat ttg cag gaa ata tat aat tca aat aat caa      548
 Asp Ser Ser Ile Arg Tyr Leu Gln Glu Ile Tyr Asn Ser Asn Asn Gln
 130                 135                 140                 145

 aag att gtt aac ctg aaa gag aag gta gcc cag ctt gaa gca cag tgc      596
 Lys Ile Val Asn Leu Lys Glu Lys Val Ala Gln Leu Glu Ala Gln Cys
                 150                 155                 160

 cag gaa cct tgc aaa gac acg gtg caa atc cat gat atc act ggg aaa      644
 Gln Glu Pro Cys Lys Asp Thr Val Gln Ile His Asp Ile Thr Gly Lys
             165                 170                 175

 gat tgt caa gac att gcc aat aag gga gct aaa cag agc ggg ctt tac      692
 Asp Cys Gln Asp Ile Ala Asn Lys Gly Ala Lys Gln Ser Gly Leu Tyr
         180                 185                 190

 ttt att aaa cct ctg aaa gct aac cag caa ttc tta gtc tac tgt gaa      740
 Phe Ile Lys Pro Leu Lys Ala Asn Gln Gln Phe Leu Val Tyr Cys Glu
     195                 200                 205

 atc gat ggg tct gga aat gga tgg act gtg ttt cag aag aga ctt gat      788
 Ile Asp Gly Ser Gly Asn Gly Trp Thr Val Phe Gln Lys Arg Leu Asp
 210                 215                 220                 225

 ggc agt gta gat ttc aag aaa aac tgg att caa tat aaa gaa gga ttt      836
 Gly Ser Val Asp Phe Lys Lys Asn Trp Ile Gln Tyr Lys Glu Gly Phe
                 230                 235                 240

 gga cat ctg tct cct act ggc aca aca gaa ttt tgg ctg gga aat gag      884
 Gly His Leu Ser Pro Thr Gly Thr Thr Glu Phe Trp Leu Gly Asn Glu
             245                 250                 255

 aag att cat ttg ata agc aca cag tct gcc atc cca tat gca tta aga      932
 Lys Ile His Leu Ile Ser Thr Gln Ser Ala Ile Pro Tyr Ala Leu Arg
         260                 265                 270

 gtt gga ctt gga aga ctg gaa tgg cag aac cag tac ctg gga caa tga      980
 Val Gly Leu Gly Arg Leu Glu Trp Gln Asn Gln Tyr Leu Gly Gln 
     275                 280                 285

 caatgataag tttgaaggca actgtgctga acaggatgga tctggttggt ggatgaacaa   1040

 gtgtcacgct ggccatctca atggagttta ttaccaaggt ggcacttact caaaagcatc   1100

 tactcctaat ggttatgata atggcattat ttgggccact tggaaaaccc ggtggtattc   1160

 catgaagaaa accactatga agataatccc attcaacaga ctcacaattg gagaaggaca   1220

 gcaacaccac ctggggggag ccaaacaggc tggagacgtt taaaagaccg tttcaaaaga   1280

 gatttacttt tttaaaggac tttatctgaa cagagagata taatattttt cctattggac   1340

 aatggacttg caaagcttca cttcatttta agagcaaaag accccatgtt gaaaactcca   1400

 taacagtttt atgctgatga taatttatct acatgcattt caataaacct tttgtttcct   1460

 aaaaaaaaaa a                                                        1471




      <210> 182
      <211> 1781
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (211)..(1446)

      <400> 182
 aagtaattcg gcacgaggca gtcaaatgca gtctggcttc ttggacatct tcatctatct     60

 actctatcct caagtcaaag tagagcctct gttcctactg actatagcta cttgcctgaa    120

 agcagtttta ttggagcagc tattggcttc ttcattacag gaggaaaaaa aggtcctgaa    180

 tctgtgcctc cttcccttct taaagtagtg     atg aaa ccc ata gca act gtt     231
                                      Met Lys Pro Ile Ala Thr Val
                                        1               5

 gga gaa agc tac caa tat cct cct gtg aac tgg gct gca ctt ctc tct      279
 Gly Glu Ser Tyr Gln Tyr Pro Pro Val Asn Trp Ala Ala Leu Leu Ser
          10                  15                  20

 cca ctt atg agg cta aat ttt ggt gaa gag atc cag caa ctg tgc ctt      327
 Pro Leu Met Arg Leu Asn Phe Gly Glu Glu Ile Gln Gln Leu Cys Leu
      25                  30                  35

 gaa att atg gtg acc cag gca cag tca tcc cag aat gca gct gca cta      375
 Glu Ile Met Val Thr Gln Ala Gln Ser Ser Gln Asn Ala Ala Ala Leu
  40                  45                  50                  55

 ttg ggc ttg tgg gtg aca cca cca ctg atc cac agt ctg agt ctg aat      423
 Leu Gly Leu Trp Val Thr Pro Pro Leu Ile His Ser Leu Ser Leu Asn
                  60                  65                  70

 acc aag aga tat ctc ctg ata tct gca cct ctg tgg ata aaa cac atc      471
 Thr Lys Arg Tyr Leu Leu Ile Ser Ala Pro Leu Trp Ile Lys His Ile
              75                  80                  85

 tct gat gaa cag atc ctg ggt ttt gtt gaa aat tta atg gtg gca gtt      519
 Ser Asp Glu Gln Ile Leu Gly Phe Val Glu Asn Leu Met Val Ala Val
          90                  95                 100

 ttt aaa gca gct tcc cca ctt gga agt cct gag cta tgc cca agt gct      567
 Phe Lys Ala Ala Ser Pro Leu Gly Ser Pro Glu Leu Cys Pro Ser Ala
     105                 110                 115

 tta cac ggt ctg agc cag gcc atg aaa ctg ccc agc cct gcc cac cac      615
 Leu His Gly Leu Ser Gln Ala Met Lys Leu Pro Ser Pro Ala His His
 120                 125                 130                 135

 ctc tgg agt ctg ctc tct gaa gct act ggg aaa att ttt gac ctc ctg      663
 Leu Trp Ser Leu Leu Ser Glu Ala Thr Gly Lys Ile Phe Asp Leu Leu
                 140                 145                 150

 cca aat aag att cgg aga aag gat cta gag ctg tat atc agc ata gca      711
 Pro Asn Lys Ile Arg Arg Lys Asp Leu Glu Leu Tyr Ile Ser Ile Ala
             155                 160                 165

 aaa tgc ctc tta gaa atg aca gat gat gat gcc aat cgg atc gcc cag      759
 Lys Cys Leu Leu Glu Met Thr Asp Asp Asp Ala Asn Arg Ile Ala Gln
         170                 175                 180

 gtt act aag agc aac ata gaa aaa gct gcc ttt gtc aaa ctg tac tta      807
 Val Thr Lys Ser Asn Ile Glu Lys Ala Ala Phe Val Lys Leu Tyr Leu
     185                 190                 195

 gtc tct caa gga cga ttc ccc ttg gtg aac ctg acc gat atg ctg agc      855
 Val Ser Gln Gly Arg Phe Pro Leu Val Asn Leu Thr Asp Met Leu Ser
 200                 205                 210                 215

 gtt gct gtg cag cac cgt gag aaa gag gtg ttg gcc tgg atg att ctg      903
 Val Ala Val Gln His Arg Glu Lys Glu Val Leu Ala Trp Met Ile Leu
                 220                 225                 230

 cac agc tta tac cag gca cgg att gtg agc cat gcc aat acg ggc gtt      951
 His Ser Leu Tyr Gln Ala Arg Ile Val Ser His Ala Asn Thr Gly Val
             235                 240                 245

 ttg aag aga atg gag tgg ctc ttg gaa ctg atg ggt tat att aga aat      999
 Leu Lys Arg Met Glu Trp Leu Leu Glu Leu Met Gly Tyr Ile Arg Asn
         250                 255                 260

 gtt gct tac cag tca aca tcc ttt cac aat acg gct ctt gac gag gct     1047
 Val Ala Tyr Gln Ser Thr Ser Phe His Asn Thr Ala Leu Asp Glu Ala
     265                 270                 275

 ttg gac ttc ttc ttg ctg ata ttt gca acc gca gtg gtt gca tgg gct     1095
 Leu Asp Phe Phe Leu Leu Ile Phe Ala Thr Ala Val Val Ala Trp Ala
 280                 285                 290                 295

 gac cac act gcc cct ctc ctc ctc ggc ctc agt gcc agt tgg ttg cca     1143
 Asp His Thr Ala Pro Leu Leu Leu Gly Leu Ser Ala Ser Trp Leu Pro
                 300                 305                 310

 tgg cat cag gag aat ggc ccg gct ggg cca gta cca agc ttc ctt ggc     1191
 Trp His Gln Glu Asn Gly Pro Ala Gly Pro Val Pro Ser Phe Leu Gly
             315                 320                 325

 agg agt cca atg cac agg gtc act ctg cag gag gtt ctc act ctc ctt     1239
 Arg Ser Pro Met His Arg Val Thr Leu Gln Glu Val Leu Thr Leu Leu
         330                 335                 340

 ccc aat agc atg gct ctg ctg ctg cag aaa gag cca tgg aag gaa cag     1287
 Pro Asn Ser Met Ala Leu Leu Leu Gln Lys Glu Pro Trp Lys Glu Gln
     345                 350                 355

 acc cag aag ttc att gac tgg cta ttc agc atc atg gaa agc cct aaa     1335
 Thr Gln Lys Phe Ile Asp Trp Leu Phe Ser Ile Met Glu Ser Pro Lys
 360                 365                 370                 375

 gaa gcc ctc tca gca cag tcc agg gat ctt ttg aaa gcc acc ctg ctg     1383
 Glu Ala Leu Ser Ala Gln Ser Arg Asp Leu Leu Lys Ala Thr Leu Leu
                 380                 385                 390

 tcc ttg aga gtt ctc cca gag ttt aag aag aaa gct gta tgg acc aga     1431
 Ser Leu Arg Val Leu Pro Glu Phe Lys Lys Lys Ala Val Trp Thr Arg
             395                 400                 405

 gca tat ggt tgg tga acagttttgc agtaaccagc agcattctca gctggatgag     1486
 Ala Tyr Gly Trp 
         410

 gaaaaccata taagtggaag aagtttttca gaattcatgc ctggtattgc tgagacatga   1546

 tgcagagagt taagggtcat gaaaagatgg ccacatcact gacagcttga cacatgcctc   1606

 ctaagagagg agtgcattgc tttagtaccc gggccagttg agactgaaac aggaacttgg   1666

 attttcttta tttggcttga gttcaatgtg gagattttct ttgtgaaagc ttgaagatat   1726

 tatcttctcc ctgctaaatt ccagtaaaat aatgttgtca atttaaaaaa aaaaa        1781




      <210> 183
      <211> 829
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (45)..(290)

      <400> 183
 ccgagtgagg cgacggggta ggggttggcg ctcaggcggc gacc atg gcg tat cac      56
                                                  Met Ala Tyr His
                                                    1

 ggc ctc act gtg cct ctc att gtg atg agc gtg ttc tgg ggc ttc gtc      104
 Gly Leu Thr Val Pro Leu Ile Val Met Ser Val Phe Trp Gly Phe Val
   5                  10                  15                  20

 ggc ttc ttg gtg cct tgg ttc atc cct aag ggt cct aac cgg gga gtt      152
 Gly Phe Leu Val Pro Trp Phe Ile Pro Lys Gly Pro Asn Arg Gly Val
                  25                  30                  35

 atc att acc atg ttg gtg acc tgt tca gtt tgc tgc tat ctc ttt tgg      200
 Ile Ile Thr Met Leu Val Thr Cys Ser Val Cys Cys Tyr Leu Phe Trp
              40                  45                  50

 ctg att gca att ctg gcc caa ctc aac cct ctc ttt gga ccg caa ttg      248
 Leu Ile Ala Ile Leu Ala Gln Leu Asn Pro Leu Phe Gly Pro Gln Leu
          55                  60                  65

 aaa aat gaa acc atc tgg tat ctg aag tat cat tgg cct tga ggaagaa      297
 Lys Asn Glu Thr Ile Trp Tyr Leu Lys Tyr His Trp Pro 
      70                  75                  80

 gacatgctct acagtgctca gtctttgagg tcacgagaag agaatgcctt ctagatgcaa    357

 aatcacctcc aaaccagacc acttttcttg acttgcctgt tttggccatt agctgcctta    417

 aacgttaaca gcacatttga atgccttatt ctacaatgca gcgtgttttc ctttgccttt    477

 tttgcacttt ggtgaattac gtgcctccat aacctgaact gtgccgactc cacaaaacga    537

 ttatgtactc ttctgagata gaagatgctg ttcttctgag agatacgtta ctctctcctt    597

 ggaatctgtg gatttgaaga tggctcctgc cttctcacgt gggaatcagt gaagtgttta    657

 gaaactgctg caagacaaac aagactccag tggggtggtc agtaggagag cacgttcaga    717

 gggaagagcc atctcaacag aatcgcacca aactatactt tcaggatgaa tttcttcttt    777

 ctgccatctt ttggaataaa tattttcctc ctttctatgg aaaaaaaaaa aa            829




      <210> 184
      <211> 6170
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (394)..(978)

      <400> 184
 tacattgcga caccgcaacg gaattcccgg gtcgacccac gcgtccgacg aaatcatctc     60

 aagcacagac aggagacttt gttttacatg ataaagcagc gggaagattt tgaacccttt    120

 gtagaagatg acattccttt tgagaagcat gtggccagtt tggcaaagcc tggtactttt    180

 gctggcaatg atgcaattgt agcctttgca agaaatcatc agttgaatgt agtgattcat    240

 caacttaatg cccctttgtg gcagattcgt ggtacagaga aaagcagcgt gagggagtta    300

 cacatcgcat atcggtatgg agagcactac gacagtgttc ggaggatcaa tgacaactca    360

 taggcacctg cacatctcca gacggatttt cag atg ctt cat caa gat gaa tca     414
                                      Met Leu His Gln Asp Glu Ser
                                        1               5

 aat aaa aga gaa aag atc aag aca aag gga atg gac tct gaa gac gac      462
 Asn Lys Arg Glu Lys Ile Lys Thr Lys Gly Met Asp Ser Glu Asp Asp
          10                  15                  20

 ctg aga gat gaa gta gag gat gct gtc cag aaa gtt tgt aat gca act      510
 Leu Arg Asp Glu Val Glu Asp Ala Val Gln Lys Val Cys Asn Ala Thr
      25                  30                  35

 gga tgt tca gat ttt aat tta ata gtc cag aac ctg gaa gct gaa aat      558
 Gly Cys Ser Asp Phe Asn Leu Ile Val Gln Asn Leu Glu Ala Glu Asn
  40                  45                  50                  55

 tat aat att gaa tct gca ata att gcc gtg ctt cgg atg aac caa ggg      606
 Tyr Asn Ile Glu Ser Ala Ile Ile Ala Val Leu Arg Met Asn Gln Gly
                  60                  65                  70

 aag aga aat aat gca gaa gag aat ctt gag ccc agt ggt cga gtg ctg      654
 Lys Arg Asn Asn Ala Glu Glu Asn Leu Glu Pro Ser Gly Arg Val Leu
              75                  80                  85

 aag cag tgt ggc cct ttg tgg gag gag ggt ggc agt ggt gcc aga atc      702
 Lys Gln Cys Gly Pro Leu Trp Glu Glu Gly Gly Ser Gly Ala Arg Ile
          90                  95                 100

 ttt gga aat cag ggc tta aat gaa ggc agg acc gaa aac aat aag gca      750
 Phe Gly Asn Gln Gly Leu Asn Glu Gly Arg Thr Glu Asn Asn Lys Ala
     105                 110                 115

 cag gcc agc cct agt gaa gaa aac aaa gca aat aaa aac cag ctc gca      798
 Gln Ala Ser Pro Ser Glu Glu Asn Lys Ala Asn Lys Asn Gln Leu Ala
 120                 125                 130                 135

 aag gtc aca aac aaa cag agg cga gaa cag cag tgg atg gag aag aag      846
 Lys Val Thr Asn Lys Gln Arg Arg Glu Gln Gln Trp Met Glu Lys Lys
                 140                 145                 150

 aag cgg cag gag gag agg cac cgc cac aaa gcc ctg gag agc aga ggt      894
 Lys Arg Gln Glu Glu Arg His Arg His Lys Ala Leu Glu Ser Arg Gly
             155                 160                 165

 agc cac agg gac aat aac aga agc gaa gca gag gcg aac acg cag gtc      942
 Ser His Arg Asp Asn Asn Arg Ser Glu Ala Glu Ala Asn Thr Gln Val
         170                 175                 180

 acc ttg gtg aag acc ttc gcc gct ctc aac atc tga ctct ttggcctctt      992
 Thr Leu Val Lys Thr Phe Ala Ala Leu Asn Ile 
     185                 190

 gggagttgta agaagcggct ggaaaaggat tgctgtgtgc tagactttcc agtgaggccg   1052

 tccttttata aaacgcaaca caaccaacga agcccacaca tgagctcaca cactgagtta   1112

 gtttcgttca agctgcctct ttttttgttc gaagttttat tagtgatatg ttggtgtttt   1172

 atgaaaatgc agtgaggcca ttcatattct gtaatacaaa attaaaatac tgagttttag   1232

 gggcagatag ttaggtcagg aaaaaccttt taagtggtgg ctttatttgc cctgaaaatc   1292

 agacttcagt gaccctagga tctttcctta acatttgggg tgagttttgc tgtaattgtt   1352

 catgagtagt ttagaataat tgttagaaat tcagaatgac aagtttcctt agtttctctt   1412

 tcattctcaa acagatatat agggtagctt ataaatgatc tccaactcag gaatatgctt   1472

 tgatttactt ctaatccaag ttactcagaa aataattcag gaattgtttt cccaaagtta   1532

 cgtgagggtt gtggcctgca gtcaggatgg aaattaaccg catttctctc cttcctgatt   1592

 ctgatgttat ttcagatggg atgcaggtgc tgttagttca tttgcactca agccatatga   1652

 taaatgcagc tgactgttaa ttaggcctgg ccttgttggg aagttgatag tggtgttggg   1712

 tttttggtat ttgtttcctg acagtgggga gatggcatgt tactgcttgt gatacagttc   1772

 tggaattctg atagtgtgta gagcagggtc tatagttgta acaggagacg aactcctggg   1832

 gttttgccta agaggagtct aaagaattat gtttttatag gagaagcctg gaagaataag   1892

 gtttttcatg ttcgcatttt aaataacgat tttcttccct tctgttgtag acttagatgc   1952

 cttcagagag atacgtggta acttgacctt ataggtcgct aaacttagta ttgtggaaat   2012

 taaatcttat aaaatgctac atttatttct ttttatttaa gccctgtttg gtatttcaaa   2072

 gttgggaaaa ctccagcatc tgctggaagt tgttggacca gcagggttgg ttgacttagg   2132

 ttggaccagc agagaagaga acatactttg gttgaggcct tcgaatcact cttcagttct   2192

 gaaatagaca gacttgagca gtggagagac gtctttccta aaactgagtt aggtggatgt   2252

 gaacttaaga actataacgt atgaggcagc ccatcttgga tcatctttgt cttttgggac   2312

 ctaatacttg ggcaaataat tgatgctgag ttgaaaggta aattattagt tatcttcccc   2372

 acccctcgca tttcagaatt ataaaaattc ggaggcaaat tgaaaactaa aatgtttggt   2432

 aggccctgga gtcgccagat tgtctttatc accaggcctt tggctttctt cagtttcact   2492

 ggtatctttt ggttttgttt ttgactttgg tggctttttg tagttggagc atcagtagtc   2552

 tcttggaatt gctcctagga cattgtggtt taggtttctt cctgggtaca gtacattgta   2612

 aaatttagca gattaaaaaa agtacacagc attttttttc tgtgcacgtc gcagagtcct   2672

 gagcttgagg ctgtgttact ctactcattc caaacgaatg aaagatctct gttgccttac   2732

 tctaaggaag tgggatcgag tgcgttagga tctatggttg tcttggtttt caactctggg   2792

 cagattcctg actggctgag tgtttctgaa tgaagatgtt ttcctgtctg ttttgtactg   2852

 cttgagtgca gaggccagat cctctcagaa agataagatt gtatgccaga aattcagatt   2912

 agcagtcagc ttaagagaga cttattgtca gaagtagtag aattgcttta tttacttggt   2972

 taatgaaggt ggccttgggc cctattgggt tttagaagtt ttagaagctg ctaaaaagtt   3032

 attaaagaat attgggaaca tttatttttt aaattaccta attctggtaa taggcttcag   3092

 catttctgga gtataataat ggtggtttaa aaaactaatc aaacggcttt agtaatttta   3152

 ctactggttt cacagctttt cagttacagt tggtctgttt agtgtgttaa ttattaggaa   3212

 tcgggtacat gcatccaact tcagtgatac cttctagcta atggtttcaa tttagacttc   3272

 actgcctcag tctcactggg tacatgagaa ggttggaatc aacatgctta gttgcctcag   3332

 tgggcacttg aaaattcctt cactggcagc ccgagtggag gcccagtatg tctagtcctg   3392

 ggatgactgt tgtcagcagc tgttactcta gtacaggtgc tcctgtgaac tctttattag   3452

 gaactgaatg tgtcttaacc tctgtgttac atcttggctg gcagagattt atgttacatg   3512

 agattgtctt ggtagcttgt agtgtggtca ggagaaaggg gatggagcag tggtgcatag   3572

 ctgcttactg ctcttataaa cggtatataa aggttttacg gattttgaaa atattttttt   3632

 ttagaggtca aaataaatac cattttagtg gcaacagctt tgaactagag aggtagatgt   3692

 attaaagcag catagaacca taacttctag ataatgtagt tgccactagg agatattaga   3752

 aagttagaat gtatgtgtgt atttagtttt tcaataataa tgaacataca ctttcaggag   3812

 caaagtatgg ttgagaaatt gtggcagaaa gaattttaaa tgttagtcga agttgtctgt   3872

 agtttcttta ttaagctctg aaaacacttc caatgccagt ttgattctga gggcttggga   3932

 agtgggatct cccttgtgga gcagctggag ctggctggga gggagcctct ccatgggtaa   3992

 tttattatgc ctgccctgct tcccccaggg agctgcttca gtgtgaaatg atgtgattgt   4052

 cgggggtggg gtgggaggag ggccaccttc agtcggggag ttgctcacat attacacagg   4112

 tagcatcagg tggacttcag cgctgaactg tactagtagt gagtccctgt agtcaatgtg   4172

 caatttctct aattctgaga aactctgtag actctgcctg ggttttactg ggtcagcata   4232

 gaatgctatc agtttacctc tgtgaaatat tcagtcagtt gaaggaaact tggattccta   4292

 gtcagaggtg actaaaagtt accctgacca aaaggatctc tgcgggggga agagaatgga   4352

 gcttcctgat tttaatgtgt tgcgtcagtg gccctcttcg actcccgttt tgggtagatg   4412

 cgtagctctt cactttctta cctcaaggct ctgtctagcc atgttaaatc tttagactca   4472

 gtctgatgcc gtttttctgt tttgccattc tcattattca cagctttcag aacaagtgtt   4532

 gctaaaactc cggggccttt gacagttgtt ctgaggtgat ttaataatgg actttttata   4592

 agttatgttt tcctggctct aaagtaaatt tttttttttt tttttttttg agacagagtc   4652

 ttgctttgtt gcccaggctg gagtgtggtg gggcaatctc ggctcactgc aacctccacc   4712

 tcccgggttc aagcgattct cctgcctcag cctcctgagt agctgggatt acaggtgtgt   4772

 gccaccatgc ttggctaatt tttgtatttt tagtagagac ggggtttcac catgttagcc   4832

 aggctggtct caaactcctg accttgtgat ctgcccgcct cagcctccca aagtgctagg   4892

 attacgggtg tgagcaaccc tgcccggcca gtaaattgta tttttttaat gacatcattg   4952

 atttgaagat ctagatggca taaattacga cgtctgccat cgcatattag aaaggggaca   5012

 gtcatatttg taacgtggag agaacacgga gcaccagtca ccacgtgcac ttaggatgca   5072

 gagcttaccg cacaccgctg atggggacct ccggaaagag cggtgccttg tggttggcct   5132

 ggaagttctc tcccaaggtg aaattccttt aaaacctcag gctctgacct atgtctttga   5192

 agcagctgct ttgtagagtc cctctcttta ctgtcctcgt taggactgtt ttgtggttcc   5252

 atgaaaatgt ttagcatcct tgcagaatta cttgagaagg ggctggtacc agtgtaaaga   5312

 atctatttct gtaaaactac gaacttttgc atagggaatt tattctaagc aggtcatagc   5372

 cgtgatccag agctgctgct gctcactgcc agtccttgcg gctggcggcg attgccggac   5432

 agactctctg tggcctggct ctcatccttg gcgtgtcagc ctgcggcagg ctgccagcca   5492

 tccatgacaa tcatgtgagc tcagccacag acctcagctg gcggtttgat ccctggcagg   5552

 tccctcgagc agtactggta agaggcttca cacattttcc cactcttaca gttcattttt   5612

 catagtagga agggcccttg gcctccccag tgcctcttcc agagcctcca ccagcactaa   5672

 gctcagagga aagaagaaaa gggccaggag tcagacgtca cacccggggg ctcccctttc   5732

 ccatgtagaa gtgttggcat gcgtcagtct cctttacaga ggggtggatg tatccgtgga   5792

 ggaggggcct tctctctttc taattgcact atacttgttc tagcttcagt ctggagatac   5852

 ttaagacctc catggggtcg tgatccatag acttagcaag tcttgcctta tctatggagc   5912

 tcgatggtga gaattgtgac cattgtctga tgtccatagt tccttccccc tagattgttt   5972

 ctttccacgg attgtgttca tctgaaccat tttatttttt atttaccaaa gtactgtact   6032

 tggctatttg cagtgttttc aaaaccaaat gtttcttttt ttgtgttttt aatcttcgat   6092

 acttggtgca atagaagctg caaagatgtg ccactttatc tatgaaatgg agttttgtat   6152

 accaataaat tctagttt                                                 6170




      <210> 185
      <211> 683
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (244)..(672)

      <400> 185
 cgaattcccg ggtttctgca agtcggaagg gaactccctt agatcccgcc cagaacctgg     60

 aattccagag cacacagggc caggacacct ttgtacccct gctccccacc ggcacaggtc    120

 ccacccaccc ccttctcccc gccccatgcc cgggtggagc cagctgccag ggcgccaaga    180

 ctcccagccc tctctctgtg cacggcagag tagaggccaa gggagggctc tgtgccagcc    240

 ccg  atg agg acg ctg ctg acc atc ttg act gtg gga tcc ctg gct gct     288
      Met Arg Thr Leu Leu Thr Ile Leu Thr Val Gly Ser Leu Ala Ala
        1               5                  10                  15

 cac gcc cct gag gac ccc tcg gat ctg ctc cag cac gtg aaa ttc cag      336
 His Ala Pro Glu Asp Pro Ser Asp Leu Leu Gln His Val Lys Phe Gln
                  20                  25                  30

 tcc agc aac ttt gaa aac atc ctg acg tgg gac agc ggg ccg gag ggc      384
 Ser Ser Asn Phe Glu Asn Ile Leu Thr Trp Asp Ser Gly Pro Glu Gly
              35                  40                  45

 acc cca gac acg gtc tac agc atc gag tat aag acg tac gga gag agg      432
 Thr Pro Asp Thr Val Tyr Ser Ile Glu Tyr Lys Thr Tyr Gly Glu Arg
          50                  55                  60

 gac tgg gtg gca aag aag ggc tgt cag cgg atc acc cgg aag tcc tgc      480
 Asp Trp Val Ala Lys Lys Gly Cys Gln Arg Ile Thr Arg Lys Ser Cys
      65                  70                  75

 aac ctg acg gtg gag acg ggc aac ctc acg gag ctc tac tat gcc agg      528
 Asn Leu Thr Val Glu Thr Gly Asn Leu Thr Glu Leu Tyr Tyr Ala Arg
  80                  85                  90                  95

 gtc acc gct gtc agt gcg gga ggc cgg tca gcc acc aag atg act gac      576
 Val Thr Ala Val Ser Ala Gly Gly Arg Ser Ala Thr Lys Met Thr Asp
                 100                 105                 110

 agg ttc agc tct ctg cag cac aca aga aga ccc aca gca ttc atc aca      624
 Arg Phe Ser Ser Leu Gln His Thr Arg Arg Pro Thr Ala Phe Ile Thr
             115                 120                 125

 ttc tca aag gag tct gta aac cag caa agc tac cct caa gcc acc tga      672
 Phe Ser Lys Glu Ser Val Asn Gln Gln Ser Tyr Pro Gln Ala Thr 
         130                 135                 140

 tgtgacctgt a                                                         683




      <210> 186
      <211> 1567
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (362)..(1567)

      <400> 186
 ttcccgggtc gacgatttcg tcgcgcaccg gcggcagagt cccttgcgtg gattggcaag     60

 cgacgcccca cctgccccga gctcaccatt ttctttcgcg ctggctgcag ctgacccggc    120

 gaagggagcc gaccgggccc tgggctggag gtaaaacccc acggaaagaa catgaggttc    180

 ccttggaaat cattcaagag gaagatggaa ggggctgttt agaagagctt aaaagctaca    240

 ggctgtaaga ctggggcctg agtgctggca gtggaaaaca ctgttgggct gtgatctctc    300

 cctgaaaagt tccaggtgcc tcttcgcttc ctgcaaaaga aaggaagcga aagagaagac    360

 c    atg tcc ata gcc ctg aag cag gta ttc aac aag gac aag acc ttc     406
      Met Ser Ile Ala Leu Lys Gln Val Phe Asn Lys Asp Lys Thr Phe
        1               5                  10                  15

 cga ccc aag agg aaa ttt gaa cct ggc aca cag agg ttt gag ctg cac      454
 Arg Pro Lys Arg Lys Phe Glu Pro Gly Thr Gln Arg Phe Glu Leu His
                  20                  25                  30

 aaa cgg gct cag gca tcc ctc aac tcg ggt gtg gac ctg aag gcg gct      502
 Lys Arg Ala Gln Ala Ser Leu Asn Ser Gly Val Asp Leu Lys Ala Ala
              35                  40                  45

 gtg cag ttg ccc agt ggg gag gac cag aat gac tgg gtg gca gta cat      550
 Val Gln Leu Pro Ser Gly Glu Asp Gln Asn Asp Trp Val Ala Val His
          50                  55                  60

 gtg gtg gac ttc ttc aat cgg atc aac ctc atc tat ggc acc atc tgt      598
 Val Val Asp Phe Phe Asn Arg Ile Asn Leu Ile Tyr Gly Thr Ile Cys
      65                  70                  75

 gag ttc tgc acc gag cgg acc tgt cct gtg atg tca ggg ggc ccc aaa      646
 Glu Phe Cys Thr Glu Arg Thr Cys Pro Val Met Ser Gly Gly Pro Lys
  80                  85                  90                  95

 tat gag tat cgg tgg cag gat gat ctc aag tat aag aag cca aca gcg      694
 Tyr Glu Tyr Arg Trp Gln Asp Asp Leu Lys Tyr Lys Lys Pro Thr Ala
                 100                 105                 110

 ctg cca gct ccc cag tac atg aac ctt ctt atg gat tgg att gag gtt      742
 Leu Pro Ala Pro Gln Tyr Met Asn Leu Leu Met Asp Trp Ile Glu Val
             115                 120                 125

 cag atc aac aac gag gaa ata ttt cca aca tgc gtg gtg aat tct cat      790
 Gln Ile Asn Asn Glu Glu Ile Phe Pro Thr Cys Val Val Asn Ser His
         130                 135                 140

 gta tcc ttt gag gtt cag ctc aga tac cat gtc ctc tgt gaa ggc ttt      838
 Val Ser Phe Glu Val Gln Leu Arg Tyr His Val Leu Cys Glu Gly Phe
     145                 150                 155

 cat cca tta gaa tac cag ctc ttt aaa tta tgc aat atg tct aat tca      886
 His Pro Leu Glu Tyr Gln Leu Phe Lys Leu Cys Asn Met Ser Asn Ser
 160                 165                 170                 175

 tct gac tat cac cca cta act cta gtc ctg gta act ttc aag tta ttg      934
 Ser Asp Tyr His Pro Leu Thr Leu Val Leu Val Thr Phe Lys Leu Leu
                 180                 185                 190

 gat gga tgg atg gat gga tgg atg gac ggc ctg gga att cta cta cag      982
 Asp Gly Trp Met Asp Gly Trp Met Asp Gly Leu Gly Ile Leu Leu Gln
             195                 200                 205

 tta aca gga aga aaa gaa gtt gct aaa tat tgc gga ctt acc tat tat     1030
 Leu Thr Gly Arg Lys Glu Val Ala Lys Tyr Cys Gly Leu Thr Tyr Tyr
         210                 215                 220

 ggc cct cag ata agc cat cca tat ttg gca tct caa agt gga aaa gaa     1078
 Gly Pro Gln Ile Ser His Pro Tyr Leu Ala Ser Gln Ser Gly Lys Glu
     225                 230                 235

 aaa gcc tgc agc cag ggg cat ttg tct tcc cat gtt ttt gaa gag aaa     1126
 Lys Ala Cys Ser Gln Gly His Leu Ser Ser His Val Phe Glu Glu Lys
 240                 245                 250                 255

 tgt gag caa atg tgt caa cga gaa atg gaa gaa gag gaa gct aac gtt     1174
 Cys Glu Gln Met Cys Gln Arg Glu Met Glu Glu Glu Glu Ala Asn Val
                 260                 265                 270

 gag caa tgt gat ata gta agc tcc aga gcc cac act cta gaa atg gta     1222
 Glu Gln Cys Asp Ile Val Ser Ser Arg Ala His Thr Leu Glu Met Val
             275                 280                 285

 gat ttg gga gtc aaa atc ggg cag tct gat ctc aga tcc att tac tta     1270
 Asp Leu Gly Val Lys Ile Gly Gln Ser Asp Leu Arg Ser Ile Tyr Leu
         290                 295                 300

 acg acc agt cta tac aac aca gtg acc aag agc cac aaa gcg cag ggg     1318
 Thr Thr Ser Leu Tyr Asn Thr Val Thr Lys Ser His Lys Ala Gln Gly
     305                 310                 315

 tgg ttc att gaa cta gcc tct cca cag gaa atg act ttt ggc cca tgg     1366
 Trp Phe Ile Glu Leu Ala Ser Pro Gln Glu Met Thr Phe Gly Pro Trp
 320                 325                 330                 335

 acc act gga tat gcc agg cca ggc atg tca gac tcc ctg gct cag gga     1414
 Thr Thr Gly Tyr Ala Arg Pro Gly Met Ser Asp Ser Leu Ala Gln Gly
                 340                 345                 350

 gct ctt aaa tcc tgg aga gca gca gag tcc aca cat cca ctg gcc atg     1462
 Ala Leu Lys Ser Trp Arg Ala Ala Glu Ser Thr His Pro Leu Ala Met
             355                 360                 365

 tca gag atc ttc atg gct gcc cca ccc atc aca ggc cca gag gcc cag     1510
 Ser Glu Ile Phe Met Ala Ala Pro Pro Ile Thr Gly Pro Glu Ala Gln
         370                 375                 380

 cag gaa aaa gtg gtt ttg tgg gcc ggt ccc agg atc ccc gtg ctg tat     1558
 Gln Glu Lys Val Val Leu Trp Ala Gly Pro Arg Ile Pro Val Leu Tyr
     385                 390                 395

 gca gcc tag                                                         1567
 Ala Ala 
 400





      <210> 187
      <211> 1223
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (325)..(1152)

      <400> 187
 gatgactaga tgtcagagct ggctcccggt tgggatatga gtgactttgt ggaggatggc     60

 gcctaaatga ggcatgccaa tttccgcacc agggtgacga acataagggc tcctaaaagg    120

 ctagcccaat gtatctgtat ttccttgggg attaaaaccc atgatcttca gttcctcaga    180

 gaactgaaag ttgcaaggag aaatccagta attcctgtta tctgcaggct ttataagtca    240

 gtggagcctg cggaagtggc cagaatccag cactccaagc actgctgtct tctcacagag    300

 tcttgaagcc agagcagcgc cagg   atg tca cgg gag ctg gcc cca ctg ctg     351
                              Met Ser Arg Glu Leu Ala Pro Leu Leu
                                1               5

 ctt ctc ctc ctc tcc atc cac agc gcc ctg gcc atg agg atc tgc tcc      399
 Leu Leu Leu Leu Ser Ile His Ser Ala Leu Ala Met Arg Ile Cys Ser
  10                  15                  20                  25

 ttc aac gtc agg tcc ttt ggg gaa agc aag cag gaa gac aag aat gcc      447
 Phe Asn Val Arg Ser Phe Gly Glu Ser Lys Gln Glu Asp Lys Asn Ala
                  30                  35                  40

 atg gat gtc att gtg aag gtc atc aaa cgc tgt gac atc ata ctc gtg      495
 Met Asp Val Ile Val Lys Val Ile Lys Arg Cys Asp Ile Ile Leu Val
              45                  50                  55

 atg gaa atc aag gac agc aac aac agg atc tgc ccc ata ctg atg gag      543
 Met Glu Ile Lys Asp Ser Asn Asn Arg Ile Cys Pro Ile Leu Met Glu
          60                  65                  70

 aag ctg aac agg gaa aag ctg gtg tct gtg aag agg agt tat cac tac      591
 Lys Leu Asn Arg Glu Lys Leu Val Ser Val Lys Arg Ser Tyr His Tyr
      75                  80                  85

 cat gac tat cag gat gga gac gca gat gtg ttt tcc agg gag ccc ttt      639
 His Asp Tyr Gln Asp Gly Asp Ala Asp Val Phe Ser Arg Glu Pro Phe
  90                  95                 100                 105

 gtg gtc tgg ttc caa tct ccc cac act gct gtc aaa gac ttc gtg att      687
 Val Val Trp Phe Gln Ser Pro His Thr Ala Val Lys Asp Phe Val Ile
                 110                 115                 120

 atc ccc ctg cac acc acc cca gag aca tcc gtt aag gag atc gat gag      735
 Ile Pro Leu His Thr Thr Pro Glu Thr Ser Val Lys Glu Ile Asp Glu
             125                 130                 135

 ttg gtt gag gtc tac acg gac gtg aaa cac cgc tgg aag gcg gag aat      783
 Leu Val Glu Val Tyr Thr Asp Val Lys His Arg Trp Lys Ala Glu Asn
         140                 145                 150

 ttc att ttc atg ggt gac ttc aat gcc ggc tgc agc tac gtc ccc aag      831
 Phe Ile Phe Met Gly Asp Phe Asn Ala Gly Cys Ser Tyr Val Pro Lys
     155                 160                 165

 aag gcc tgg aag aac atc cgc ttg agg act gac ccc agg ttt gtt tgg      879
 Lys Ala Trp Lys Asn Ile Arg Leu Arg Thr Asp Pro Arg Phe Val Trp
 170                 175                 180                 185

 ctg atc ggg gac caa gag gac acc acg gtg aag aag agc acc aac tgt      927
 Leu Ile Gly Asp Gln Glu Asp Thr Thr Val Lys Lys Ser Thr Asn Cys
                 190                 195                 200

 gca tat gac agg att gtg ctt aga gga caa gaa atc gtc agt tct gtt      975
 Ala Tyr Asp Arg Ile Val Leu Arg Gly Gln Glu Ile Val Ser Ser Val
             205                 210                 215

 gtt ccc aag tca aac agt gtt ttt gac ttc cag aaa gct tac aag ctg     1023
 Val Pro Lys Ser Asn Ser Val Phe Asp Phe Gln Lys Ala Tyr Lys Leu
         220                 225                 230

 act gaa gag gag gcc ctg gat gtc agc gac cac ttt cca gtt gaa ttt     1071
 Thr Glu Glu Glu Ala Leu Asp Val Ser Asp His Phe Pro Val Glu Phe
     235                 240                 245

 aaa cta cag tct tca agg gcc ttc acc aac agc aaa aaa tct gtc act     1119
 Lys Leu Gln Ser Ser Arg Ala Phe Thr Asn Ser Lys Lys Ser Val Thr
 250                 255                 260                 265

 cta agg aag aaa aca aag agc aaa cgc tcc tag acccaagg gtctcatctt     1170
 Leu Arg Lys Lys Thr Lys Ser Lys Arg Ser 
                 270                 275

 attaaccatt tcttgcctct aaataaaatg tctctaacag aaaaaaaaaa aaa          1223




      <210> 188
      <211> 653
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (62)..(340)

      <400> 188
 gttctgaagc ttctgagttc tgcagcctca cctctgagaa aacctctttg ccaccaatac     60

 c    atg aag ctc tgc gtg act gtc ctg tct ctc ctc gtg cta gta gct     106
      Met Lys Leu Cys Val Thr Val Leu Ser Leu Leu Val Leu Val Ala
        1               5                  10                  15

 gcc ttc tgc tct cta gca ctc tca gca cca atg ggc tca gac cct ccc      154
 Ala Phe Cys Ser Leu Ala Leu Ser Ala Pro Met Gly Ser Asp Pro Pro
                  20                  25                  30

 acc gcc tgc tgc ttt tct tac acc gcg agg aag ctt cct cgc aac ttt      202
 Thr Ala Cys Cys Phe Ser Tyr Thr Ala Arg Lys Leu Pro Arg Asn Phe
              35                  40                  45

 gtg gta gat tac tat gag acc agc agc ctc tgc tcc cag cca gct gtg      250
 Val Val Asp Tyr Tyr Glu Thr Ser Ser Leu Cys Ser Gln Pro Ala Val
          50                  55                  60

 gta ttc caa acc aaa aga ggc aag caa gtc tgc gct gac ccc agt gag      298
 Val Phe Gln Thr Lys Arg Gly Lys Gln Val Cys Ala Asp Pro Ser Glu
      65                  70                  75

 tcc tgg gtc cag gag tac gtg tat gac ctg gaa ctg aac tga gctgctc      347
 Ser Trp Val Gln Glu Tyr Val Tyr Asp Leu Glu Leu Asn 
  80                  85                  90

 agagacagga agtcttcagg gaaggtcacc tgagcctgga tgcttctcca tgagccgcat    407

 ctcctccata ctcaggactc ctctccgcag ttcctgtctc ttctcttaat gtaatctctt    467

 ttatgtgctg tattattgta ttaggtgtta tttccattat ttatattagt ttagccaaag    527

 gataagtgtc ccctatgggg atggtccact ctcactcttt ctctgctgtt gcaaatacat    587

 ggataacacc gttaattcca tgtgttttca taataaaact ttaaaataaa atgcaaaaaa    647

 aaaaaa                                                               653




      <210> 189
      <211> 1266
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (974)..(1138)

      <400> 189
 ctggaagaac caagatgtaa agcccttaag aaaatctcaa tatacacatg tctacacagt     60

 cgtatacagt gtcatgccac aaatgcaggc gctggacctc attccttgtt aaaggttttg    120

 tcatatcagg ttatgaagta agattattat gtcattattg taaatggcag cttaagtatt    180

 ccgttgcagg gggcgccata acctactacg ttctctggcc ttagggagta aagttgttaa    240

 gtgtttttct ctattgtaga cacaacaaat gaatagtgtt tgtcttggtc aagactgact    300

 cctactcccg cctcctgccc tattacaagc agctcacacc ttttggaggc tctggagacg    360

 cctgtccagc gagctccgag attccgggtg ctgaacttcc ggttttactt agcctagttg    420

 ctgtaattac ttctcttgaa aagcaaaagg gcaatcttaa ttgttaaatg ctcttataaa    480

 gtacatactc tgggatcctt gtaagatgat tgtactgcaa cctttatgca ctttttactt    540

 ctttctcttt ttgttcttta atttgtttgt gtaacagagt aagcaggaaa ttcacaggag    600

 gtctgctcgg ctcagaaaca ctaaatacaa atctgctccg gctgctgaaa aaaaagtctc    660

 caccaaagga aaagggagaa gacatatatt taaattgaaa aatcccatca aagctcctga    720

 gtcagtttcc actataatca ctgcagaatc aatcttctac aagggagtat attaccaaat    780

 tggtgatgtt gtttctgtga ttgatgaaca agatggaaag ccctactatg ctcaaatcag    840

 aggttttatc caggaccagt attgcgagaa gagtgcagca ctgacgtggc tcattcctac    900

 cctctctagc cccagagacc aatttgatcc cgcctcctat atcatagggc cagaggaaga    960

 tcttccaagg aag   atg gaa tac ttg gaa ttt gtt tgt cat gca cct tct    1009
                  Met Glu Tyr Leu Glu Phe Val Cys His Ala Pro Ser
                    1               5                  10

 gag tat ttc aag tca cgg tca tca cca ttt ccc aca gtt ccc acc aga     1057
 Glu Tyr Phe Lys Ser Arg Ser Ser Pro Phe Pro Thr Val Pro Thr Arg
          15                  20                  25

 cca gag aag ggc tac ata tgg act cat gtt ggg cct act cct gca ata     1105
 Pro Glu Lys Gly Tyr Ile Trp Thr His Val Gly Pro Thr Pro Ala Ile
      30                  35                  40

 aca att aag gaa tca gtt gcc aac cat ttg tag ttcacaaa ttaaaactgg     1156
 Thr Ile Lys Glu Ser Val Ala Asn His Leu 
  45                  50

 gtttccaggc ctggtgtggt ggctcacgcc tgtagcccca gctattgcac cactgctctc   1216

 caagctgggc aacagagtca gattctcttt cttaaaaaac cacaaaaaaa              1266




      <210> 190
      <211> 704
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (160)..(423)

      <400> 190
 ctaggtgctt acctaaatca actcattgga tcctcacaac aaccctgtga ggtgggtttc     60

 ataaccccca ctgtttaccg atgaggctca cagaggctat gtaacttgcc caagattctg    120

 cagctggtaa aggacggaat ctgtgcctct gcactacca   atg cct gct cct gaa     174
                                              Met Pro Ala Pro Glu
                                                1               5

 gga agg ttt gtg agg gtg aat ttc tca aag tca ctt cag gtc ctt act      222
 Gly Arg Phe Val Arg Val Asn Phe Ser Lys Ser Leu Gln Val Leu Thr
                  10                  15                  20

 gta gcg aca gtg ttg gca cct tct gtg tcc tct ctc acc ttg cct gtg      270
 Val Ala Thr Val Leu Ala Pro Ser Val Ser Ser Leu Thr Leu Pro Val
              25                  30                  35

 agc ctt cca gtg ggt ggg aaa aga ggc gtg cct atc agt ggc cat tct      318
 Ser Leu Pro Val Gly Gly Lys Arg Gly Val Pro Ile Ser Gly His Ser
          40                  45                  50

 gtg aac aca gaa gag agc tgc gct ggc cac aga gaa gat agt cca atg      366
 Val Asn Thr Glu Glu Ser Cys Ala Gly His Arg Glu Asp Ser Pro Met
      55                  60                  65

 atc ctt aaa gtt cag gcg tgt ggg ttg gag cca aag ggg cct gtc ccc      414
 Ile Leu Lys Val Gln Ala Cys Gly Leu Glu Pro Lys Gly Pro Val Pro
  70                  75                  80                  85

 tgg ata taa cttgaga gtagctctgg agaggaattc tagaagcacc acaagggctg      470
 Trp Ile 


 aggagagtcc caaggtgcca gagaaattgt agtgaaatat cacagagagt tcttgctgaa    530

 agacactcag atgtcctggg gcttgtgtct actgtactgc ggactgacta ctcctctttt    590

 cttcctttga aaaacttatc cttgccttct cagatcaatc caagggggtt cctggggaca    650

 gctggtccaa cacgctcaaa tgaagaaagt cggacgcgtg ggtcgacccg ggaa          704




      <210> 191
      <211> 2013
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1006)..(2013)

      <400> 191
 atacgagcac tatagggaat ttggccctcg aggcaagaaa ttcgggcacg aggtgaaaac     60

 acaacccaca atcatcctcc tgaggcagat tccgctggga ctgcattcaa cttagggcca    120

 actattaagc aaactgagac aaaatgggaa tacaacaacg tgggcactga cctgtccccc    180

 gagcccaaaa gcttcaatta cccattgttc tcgtccccag gtgatcagtt tgaaattcag    240

 ctaacccaac agccacgttc cctcatcccc aacaacaatg tgagaaggct catttctcat    300

 gttatccgga ccttgaagat ggactgctct gagacccatg tgcaattgac ctgtgccaag    360

 ctcatctcca ggacaggcct cctgatgaag cttctcagtg agcagcaaga agtaaaggtg    420

 tccaaggcag aatgggatac ggaccagtgg aaaactgaga actatatcaa tgacagcaca    480

 gaagcccaga atgaacagaa agagcagaag tcgagtgagc tcacaaaaga agttccagga    540

 tacggctata ctgacaaact catcttggca ttaattgtga ctgaaatact aacgattttg    600

 attatacttt tctgcctcat tgtggtttag gattgggtgt gtgtgtctcc tctctgaatg    660

 gcactcaaat gtttgctgac tcctactctg cgtgactggg gtgtacagct atggactgat    720

 gcatcccatc ccatcatctt tcacgagcaa agcagtctct tttttgacag ctgaagaaga    780

 atctgtaggg aatccagaag gagcattcat gaagatgtta caagcccgga agaattacac    840

 aagcactgag ctgactgttg agccggagga gccctcagac agcagtggca tcaacttgtc    900

 aggctttggg agtgagcagc tagacaccaa tgacgagagt gatgttatca gtgcactaag    960

 ttacatttgc catatttctc agcagtaaac ctagatgtgg aatca    atg tta cta    1014
                                                      Met Leu Leu
                                                        1

 ccg ttc att aaa ctg cca acc aca gga aac agc ctg gca aag att caa     1062
 Pro Phe Ile Lys Leu Pro Thr Thr Gly Asn Ser Leu Ala Lys Ile Gln
       5                  10                  15

 act gta ggc caa aac cag caa aaa gtg aat aga gtc ctc atg ggc cca     1110
 Thr Val Gly Gln Asn Gln Gln Lys Val Asn Arg Val Leu Met Gly Pro
  20                  25                  30                  35

 agg agc atc cag aaa agg cac ttc aaa gag gtg gga agg cag agc atc     1158
 Arg Ser Ile Gln Lys Arg His Phe Lys Glu Val Gly Arg Gln Ser Ile
                  40                  45                  50

 agg agg gaa cag ggt gcc cag gca tct gtg gag aac gct gcc gaa gaa     1206
 Arg Arg Glu Gln Gly Ala Gln Ala Ser Val Glu Asn Ala Ala Glu Glu
              55                  60                  65

 aaa agg ctc ggg agt cca gcc cca agg gag ctg gaa cag cct cac aca     1254
 Lys Arg Leu Gly Ser Pro Ala Pro Arg Glu Leu Glu Gln Pro His Thr
          70                  75                  80

 cag cag ggg cct gag aag tta gcg gga aac gcc atc tac acc aag cct     1302
 Gln Gln Gly Pro Glu Lys Leu Ala Gly Asn Ala Ile Tyr Thr Lys Pro
      85                  90                  95

 tcg ttc acc caa gag cat aag gca gca gtc tct gtg ctg aca ccc ttc     1350
 Ser Phe Thr Gln Glu His Lys Ala Ala Val Ser Val Leu Thr Pro Phe
 100                 105                 110                 115

 tcc aag ggc gcg cct tct acc tcc agc cct gca aaa gcc cta cca cag     1398
 Ser Lys Gly Ala Pro Ser Thr Ser Ser Pro Ala Lys Ala Leu Pro Gln
                 120                 125                 130

 gtg aga gac aga tgg aaa gac aac aca cac act att tcc att tta gaa     1446
 Val Arg Asp Arg Trp Lys Asp Asn Thr His Thr Ile Ser Ile Leu Glu
             135                 140                 145

 agt gca aag gct aga gtt aca aat atg aag gct tct aaa cca att tca     1494
 Ser Ala Lys Ala Arg Val Thr Asn Met Lys Ala Ser Lys Pro Ile Ser
         150                 155                 160

 cat tcc aga aaa aaa tac cgc ttt cac aaa act cgc tcc cgc atg acc     1542
 His Ser Arg Lys Lys Tyr Arg Phe His Lys Thr Arg Ser Arg Met Thr
     165                 170                 175

 cac aga aca ccc aag gtc aaa aag agt cca aag ttc aga aag aaa agt     1590
 His Arg Thr Pro Lys Val Lys Lys Ser Pro Lys Phe Arg Lys Lys Ser
 180                 185                 190                 195

 tat ctg agt aga ctg atg ctc gca aac agg cct ccg ttc tct gca gcg     1638
 Tyr Leu Ser Arg Leu Met Leu Ala Asn Arg Pro Pro Phe Ser Ala Ala
                 200                 205                 210

 aag agc ctc ata aat tcc cct tca caa ggg gct ttt tca tcc tta gga     1686
 Lys Ser Leu Ile Asn Ser Pro Ser Gln Gly Ala Phe Ser Ser Leu Gly
             215                 220                 225

 gac ctg agt cct caa gaa aac cct ttt ctg gaa gta tct gct cct tca     1734
 Asp Leu Ser Pro Gln Glu Asn Pro Phe Leu Glu Val Ser Ala Pro Ser
         230                 235                 240

 gaa cat ttt ata gaa acc act aat ata aaa gac aca act gca aga aat     1782
 Glu His Phe Ile Glu Thr Thr Asn Ile Lys Asp Thr Thr Ala Arg Asn
     245                 250                 255

 gcc ttg gaa gaa aat gtt ttt atg gaa aac act aac atg cca gaa gtc     1830
 Ala Leu Glu Glu Asn Val Phe Met Glu Asn Thr Asn Met Pro Glu Val
 260                 265                 270                 275

 acc atc tct gaa aac aca aac tac aat cat cct cct gag gca gat tcc     1878
 Thr Ile Ser Glu Asn Thr Asn Tyr Asn His Pro Pro Glu Ala Asp Ser
                 280                 285                 290

 gct ggg act gca ttc aac tta ggg cca act gtt aaa caa act gag aca     1926
 Ala Gly Thr Ala Phe Asn Leu Gly Pro Thr Val Lys Gln Thr Glu Thr
             295                 300                 305

 aaa tgg gaa tac aac aac gtg ggc act gac ctg tcc ccc gag ccc aaa     1974
 Lys Trp Glu Tyr Asn Asn Val Gly Thr Asp Leu Ser Pro Glu Pro Lys
         310                 315                 320

 agc ttc aat tac cca ttg ctc agt ttg aaa ttc agc taa                 2013
 Ser Phe Asn Tyr Pro Leu Leu Ser Leu Lys Phe Ser 
     325                 330                 335





      <210> 192
      <211> 1312
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (522)..(1229)

      <400> 192
 ggaaagagac cctatgtgat gtgtttggac caggtggatt aaaagcgggg ggggtatacc     60

 cgggcattgg tcggaaattc ccttcaacag tcctttcctt taggggggca tcggttaatt    120

 tttccctgta gcccacgttc aggtcagctc cgcaggggct ctcgtgacta ttttcttcct    180

 ttattcatca gtgaggtatg ttcagggcct aattaattgt ggatatgagg cagggtcaag    240

 aggacaaagg aacagggcct ttactttcta catagctccc ctgtttcatc caaggaggtt    300

 aagtattgat ttttatcggt tttctcaact gtgaatataa taaactgaaa gcatttcagg    360

 gagaagctgg agaacacctt ctctagctgc actccacctt aaggctgaag ctggatttgt    420

 ttactgtttc tcctgggggc aggggcagtt gagaaataac caagtagtct gccaagccag    480

 ggtcaaccct ccaggccaca ggttgagcaa atgctacagc c    atg gac agg gag     533
                                                  Met Asp Arg Glu
                                                    1

 aca ctc ctc acg aag ggg tgg tcc tca tcc ttt cag atc aac ttc ctg      581
 Thr Leu Leu Thr Lys Gly Trp Ser Ser Ser Phe Gln Ile Asn Phe Leu
   5                  10                  15                  20

 ctg gag gct cca ccc tca cca cgt ccc tcc ctc ttc tct cat ctg gag      629
 Leu Glu Ala Pro Pro Ser Pro Arg Pro Ser Leu Phe Ser His Leu Glu
                  25                  30                  35

 tca cct ttt ggg att ttg gag ttg agc acc atg ggg act cca aat gat      677
 Ser Pro Phe Gly Ile Leu Glu Leu Ser Thr Met Gly Thr Pro Asn Asp
              40                  45                  50

 cag gca gtg ctg cag gcc atc ttc aac cct gac acc cca ttt gga gac      725
 Gln Ala Val Leu Gln Ala Ile Phe Asn Pro Asp Thr Pro Phe Gly Asp
          55                  60                  65

 att gtt gga ttg gac ctc gga gag gaa gca gaa aag gaa gaa cga gaa      773
 Ile Val Gly Leu Asp Leu Gly Glu Glu Ala Glu Lys Glu Glu Arg Glu
      70                  75                  80

 gaa gat gaa gtt ttc cct caa gca cag ctg gaa cag tcc aag gcc ctg      821
 Glu Asp Glu Val Phe Pro Gln Ala Gln Leu Glu Gln Ser Lys Ala Leu
  85                  90                  95                 100

 gag ctg cag ggg gtg atg gca gca gag gct ggg gac ctc agc aca gcc      869
 Glu Leu Gln Gly Val Met Ala Ala Glu Ala Gly Asp Leu Ser Thr Ala
                 105                 110                 115

 ctg gag agg ttt ggc caa gcc atc tgc ctg ctg cct gag agg gct tca      917
 Leu Glu Arg Phe Gly Gln Ala Ile Cys Leu Leu Pro Glu Arg Ala Ser
             120                 125                 130

 gcc tac aac aac cgt gcc cag gcc cgg cga ctc cag gga gac gtg gca      965
 Ala Tyr Asn Asn Arg Ala Gln Ala Arg Arg Leu Gln Gly Asp Val Ala
         135                 140                 145

 ggc gcc ctg gag gat ctg gaa cgc gcg gtg gag ctg agc ggc ggc cgg     1013
 Gly Ala Leu Glu Asp Leu Glu Arg Ala Val Glu Leu Ser Gly Gly Arg
     150                 155                 160

 ggc cgc gcc gcc cgc cag agc ttt gtg cag cgc gga ctc ctg gcg cgg     1061
 Gly Arg Ala Ala Arg Gln Ser Phe Val Gln Arg Gly Leu Leu Ala Arg
 165                 170                 175                 180

 ctg cag ggc cga gac gac gac gcc cgc agg gac ttc gag agg gcg gca     1109
 Leu Gln Gly Arg Asp Asp Asp Ala Arg Arg Asp Phe Glu Arg Ala Ala
                 185                 190                 195

 cgg ctg ggc agc ccc ttc gcg cgg cgc cag ctg gtg ctg ctc aac ccc     1157
 Arg Leu Gly Ser Pro Phe Ala Arg Arg Gln Leu Val Leu Leu Asn Pro
             200                 205                 210

 tac gcc gcg ctg tgc aac cgc atg ctg gcc gac atg atg ggg cag ctg     1205
 Tyr Ala Ala Leu Cys Asn Arg Met Leu Ala Asp Met Met Gly Gln Leu
         215                 220                 225

 cgc cgc ccc cgt gac agc cgc tga gcgccgcgga cccgggcgtc cgcgggcgag    1259
 Arg Arg Pro Arg Asp Ser Arg 
     230                 235

 gggacgggac tgggccctga accaataaag ccgtcgggcc tcaaaaaaaa aaa          1312




      <210> 193
      <211> 1694
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (259)..(1332)

      <400> 193
 tgtacgatct cttggattct ctagagcggc cgccgagaga ccccggaggc gccgcagaga     60

 cgggatcttg ctgtattgcc caggccggtc ttgaactcct gagttcaagc agtccacctt    120

 ggcctcccaa aatgctggga ttacaagcat gagccaccat gcctggtctg attttggaaa    180

 aattaaagaa tatggagata gcttggtgaa agagacccag atggtttggg atttctgttt    240

 ttatataaga attcacag  atg gat tca gtg gaa aag aca aca aat aga agt     291
                      Met Asp Ser Val Glu Lys Thr Thr Asn Arg Ser
                        1               5                  10

 gaa caa aaa tcc aga aag ttt tta aaa agc ctc atc cgg aaa cag ccc      339
 Glu Gln Lys Ser Arg Lys Phe Leu Lys Ser Leu Ile Arg Lys Gln Pro
              15                  20                  25

 cag gaa ctg ctc ctg gtt atc ggg act ggc gtc agc gca gca gtg gcc      387
 Gln Glu Leu Leu Leu Val Ile Gly Thr Gly Val Ser Ala Ala Val Ala
          30                  35                  40

 ccc gga atc cct gcc ctt tgc tcg tgg aga agc tgc atc gag gcc gtc      435
 Pro Gly Ile Pro Ala Leu Cys Ser Trp Arg Ser Cys Ile Glu Ala Val
      45                  50                  55

 atc gag gct gca gag cag ctg gag gtg ctg cac ccc gga gac gtc gcc      483
 Ile Glu Ala Ala Glu Gln Leu Glu Val Leu His Pro Gly Asp Val Ala
  60                  65                  70                  75

 gag ttc cgg agg aaa gtg aca aag gac cgg gac ctg ttg gtt gtc gcc      531
 Glu Phe Arg Arg Lys Val Thr Lys Asp Arg Asp Leu Leu Val Val Ala
                  80                  85                  90

 cat gat ctg atc cgg aag atg tca cct cgc aca ggc gat gcc aag ccc      579
 His Asp Leu Ile Arg Lys Met Ser Pro Arg Thr Gly Asp Ala Lys Pro
              95                 100                 105

 agc ttc ttc cag gac tgc ctg atg gag gtg ttt gac gac ctg gag cag      627
 Ser Phe Phe Gln Asp Cys Leu Met Glu Val Phe Asp Asp Leu Glu Gln
         110                 115                 120

 cac atc cgg agt cct ctg gtg ctg cag tcg atc ctc agc ctg atg gac      675
 His Ile Arg Ser Pro Leu Val Leu Gln Ser Ile Leu Ser Leu Met Asp
     125                 130                 135

 aga ggc gcc atg gtc ctg acc acc aac tat gac aac ctg ctg gag gcc      723
 Arg Gly Ala Met Val Leu Thr Thr Asn Tyr Asp Asn Leu Leu Glu Ala
 140                 145                 150                 155

 ttt ggc cgg cgg cag aac aag ccc atg gag tcc ctg gac ttg aag gac      771
 Phe Gly Arg Arg Gln Asn Lys Pro Met Glu Ser Leu Asp Leu Lys Asp
                 160                 165                 170

 aag acc aag gtc ctt gaa tgg gca aga ggg cac atg aag tac ggc gtc      819
 Lys Thr Lys Val Leu Glu Trp Ala Arg Gly His Met Lys Tyr Gly Val
             175                 180                 185

 ctc cac att cac ggc ctc tac acg gac ccc tgc ggg gtg gtg ctg gac      867
 Leu His Ile His Gly Leu Tyr Thr Asp Pro Cys Gly Val Val Leu Asp
         190                 195                 200

 cca tcg ggg tat aaa gac gtc act caa gac gca gaa gtc atg gaa gtc      915
 Pro Ser Gly Tyr Lys Asp Val Thr Gln Asp Ala Glu Val Met Glu Val
     205                 210                 215

 ctc cag aac tta tac cgc acc aag tcc ttt ctg ttt gtg ggc tgt ggg      963
 Leu Gln Asn Leu Tyr Arg Thr Lys Ser Phe Leu Phe Val Gly Cys Gly
 220                 225                 230                 235

 gag acc ctt cgt gat cag ata ttc cag gcc ctc ttt ctt tac tcc gtg     1011
 Glu Thr Leu Arg Asp Gln Ile Phe Gln Ala Leu Phe Leu Tyr Ser Val
                 240                 245                 250

 ccg aat aag gtg gat ttg gag cac tac atg ctt gtg ctg aag gag aat     1059
 Pro Asn Lys Val Asp Leu Glu His Tyr Met Leu Val Leu Lys Glu Asn
             255                 260                 265

 gaa gac cat ttc ttt aag cat cag gca gat atg ctt ctg cac gga atc     1107
 Glu Asp His Phe Phe Lys His Gln Ala Asp Met Leu Leu His Gly Ile
         270                 275                 280

 aaa gtt gta tcc tac ggg gac tgt ttt gac cac ttt cca gga tat gtg     1155
 Lys Val Val Ser Tyr Gly Asp Cys Phe Asp His Phe Pro Gly Tyr Val
     285                 290                 295

 caa gac ctt gcc act cag atc tgc aaa cag caa agc cca gat gct gat     1203
 Gln Asp Leu Ala Thr Gln Ile Cys Lys Gln Gln Ser Pro Asp Ala Asp
 300                 305                 310                 315

 cgc gtg gac agc acc aca tta ttg ggt aat gca tgc cag gac tgt gca     1251
 Arg Val Asp Ser Thr Thr Leu Leu Gly Asn Ala Cys Gln Asp Cys Ala
                 320                 325                 330

 aag agg aag tta gaa gag aat gga att gaa gtt tca aaa aaa cgc aca     1299
 Lys Arg Lys Leu Glu Glu Asn Gly Ile Glu Val Ser Lys Lys Arg Thr
             335                 340                 345

 caa tca gat act gat gat gct gga ggg tct tga aatcttta cagtaaaacc     1350
 Gln Ser Asp Thr Asp Asp Ala Gly Gly Ser 
         350                 355

 tgcaacttga aaactagcct tctgtaacca cagtgcccaa acgaagagga atgtatggag   1410

 aactccacgt ggatctctga ttgcgaaacc gtcacataca ccaagagagc cacatgggca   1470

 tgtggccctc aaggctgggt gagagggctc ccctgtgtgt tgaactatgc aggagggtga   1530

 cgcggacaca tttcaggtgg actttgcaag gactgatgga tagctacctc agggaccaga   1590

 atccgtggga agggatggac ctggtgttcc cgttcccatc tgacaggttc tcttttgtca   1650

 aggtggtatt tttcgtaata aaaggggaag agtaaaaaaa aaaa                    1694




      <210> 194
      <211> 419
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (184)..(399)

      <400> 194
 agacagaggc tgatccctat ggcaggcaac cacaaaatta agccacttac agtgttggaa     60

 tccctgggca aagatttgct cactgatgtt taggataact aggaggaaca aaatgtactg    120

 aactggaagg aagaggaaaa aaagaaatat tacgatgcta aaactgaaga caaagctcgg    180

 gtc  atg gca gac tct atg caa gag aaa cta cgt atg gca gga caa atg     228
      Met Ala Asp Ser Met Gln Glu Lys Leu Arg Met Ala Gly Gln Met
        1               5                  10                  15

 ctt ctt caa acc ttt ttt aac ata gac cac ata tcc ccc aat aaa aaa      276
 Leu Leu Gln Thr Phe Phe Asn Ile Asp His Ile Ser Pro Asn Lys Lys
                  20                  25                  30

 gct cat ccg aat atg gag gct gta cca cct gag tca gga gaa tct aca      324
 Ala His Pro Asn Met Glu Ala Val Pro Pro Glu Ser Gly Glu Ser Thr
              35                  40                  45

 gat gcc ctc aag ctt tgt tct cat gaa gaa ttc ctg aga cta tgt aag      372
 Asp Ala Leu Lys Leu Cys Ser His Glu Glu Phe Leu Arg Leu Cys Lys
          50                  55                  60

 aaa gag ctg aag aga tct atc caa taa aggagagaaa caaccgcaca            419
 Lys Glu Leu Lys Arg Ser Ile Gln 
      65                  70





      <210> 195
      <211> 727
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (44)..(382)

      <220>
      <221> misc_feature
      <222> (1)...(727)
      <223> n = a,t,c or g

      <400> 195
 gctcggantc ctgtccangt ggtgttagac gcccgtccgg gac  atg gct gag gcc      55
                                                  Met Ala Glu Ala
                                                    1

 cac aaa gag gcc atg agc cgc aaa ctg ggt cag agt gag agc cag ggc      103
 His Lys Glu Ala Met Ser Arg Lys Leu Gly Gln Ser Glu Ser Gln Gly
   5                  10                  15                  20

 cct cca cgg gcc ttc gcc aaa gtg aac agc atc agc ccc ggc tcc cca      151
 Pro Pro Arg Ala Phe Ala Lys Val Asn Ser Ile Ser Pro Gly Ser Pro
                  25                  30                  35

 gcc agc atc gcg ggt ctg caa gtg gat gat gag att gtg gag ttc ggc      199
 Ala Ser Ile Ala Gly Leu Gln Val Asp Asp Glu Ile Val Glu Phe Gly
              40                  45                  50

 tct gtg aac acc cag aac ttc cag tca ctg cat aac att ggc agt gtg      247
 Ser Val Asn Thr Gln Asn Phe Gln Ser Leu His Asn Ile Gly Ser Val
          55                  60                  65

 gtg cag cac agt gag ggg aag ccc ctg aat gtg aca gtg atc cgc agg      295
 Val Gln His Ser Glu Gly Lys Pro Leu Asn Val Thr Val Ile Arg Arg
      70                  75                  80

 ggg gaa aaa cac cag ctt aga ctt gtt cca aca cgc tgg gca gga aaa      343
 Gly Glu Lys His Gln Leu Arg Leu Val Pro Thr Arg Trp Ala Gly Lys
  85                  90                  95                 100

 gga ctg ctg ggc tgc aac att att cct ctg caa aga tga ttgtccctgg       392
 Gly Leu Leu Gly Cys Asn Ile Ile Pro Leu Gln Arg 
                 105                 110

 ggaacagtaa caggaaagca tcttcccttg ccctggactt gggtctaggg atttccaact    452

 tgtcttctct ccctgaagca taaggatctg gaagaggctt gtaacctgaa cttctgtgtg    512

 gtggcagtac tgtggcccac cagtgtaatc tccctggatt aaggcattct taaaaactta    572

 ggcttggcct ctttcacaaa ttaggccacg gccctaaata ggaattccct ggattgtggg    632

 caagtgggcg gaagttattc tggcaggtac tggtgtgatt attattatta tttttaataa    692

 agagttttac agtgctgata tgaaaaaaaa aaaaa                               727




      <210> 196
      <211> 1136
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (269)..(541)

      <400> 196
 attttctctg gtgttttcac tagttccggc ctttggcgct ctatgacgtc accgaagtga     60

 cggagcggaa aagcgcgaga agcggcttgg ttccttgtac gcagaggcgg tagtgacaca    120

 ggcacaactg agagtggcag aagctcagct gacaaggact ggggacggcg gtgtccttgt    180

 cttgcctttg tcgcccccgc ccctctcttc cctggctgga cttgcggagt ccccgccgaa    240

 gaacccgagg agccatatat tgaagacc   atg tct gga agc ttc tac ttt gta     292
                                  Met Ser Gly Ser Phe Tyr Phe Val
                                    1               5

 att gtt ggt cac cat gat aat cca gtt ttt gaa atg gag ttt ttg cca      340
 Ile Val Gly His His Asp Asn Pro Val Phe Glu Met Glu Phe Leu Pro
      10                  15                  20

 gct ggg aag gca gaa tcc aaa gac gac cat cgt cat ctg aac cag ttc      388
 Ala Gly Lys Ala Glu Ser Lys Asp Asp His Arg His Leu Asn Gln Phe
  25                  30                  35                  40

 ata gct cat gct gct ctc gac ctc gta gat gag aac atg tgg cta tcg      436
 Ile Ala His Ala Ala Leu Asp Leu Val Asp Glu Asn Met Trp Leu Ser
                  45                  50                  55

 aac aac atg tac ttg aaa act gtg gac aag ttc aac gag tgg ttt gtg      484
 Asn Asn Met Tyr Leu Lys Thr Val Asp Lys Phe Asn Glu Trp Phe Val
              60                  65                  70

 tcg gca ttt gtc act gcg ggg cat atc ctt acc ttc tta gta aag gta      532
 Ser Ala Phe Val Thr Ala Gly His Ile Leu Thr Phe Leu Val Lys Val
          75                  80                  85

 act aac taa agtttgg gctcacaaac cagaagaaca tggaacatag atgccaggct      588
 Thr Asn 
      90

 ctgagtctgt agacttcaca gtcaggtgaa aatgtaagtt tccatttatg gggctacttt    648

 tcttttttta ggggggaaaa acattttgtt taatagctaa ttttaaaact aagtctcata    708

 cacaaaaaga gtttatctgg accctatcaa gggtgatttt actttatttt acagttattt    768

 tctaactttg aaagcttatg ttctctttat gataaaacta agctaatttt aaacccagtt    828

 tatatattca acttttccat cacaaataca ctgcatgtga ctaatttgaa gaatactgta    888

 tcaacgaact ggttgctttt tgtttttcat ttctaagaaa gattatgcct taattatttc    948

 acatatgagg tttattatgc ttcatgacat aagacaagaa gatggaataa agaacttctt   1008

 tactgatgtt tatgatttat atataaaggt atggtatgtt ctataatttt taaattctga   1068

 tgagaaagga ttcgaccttt gtcaggaaac tggcctattg aagtaactcc cttaggctgc   1128

 agtttacc                                                            1136




      <210> 197
      <211> 3504
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (11)..(2899)

      <400> 197
 ggcacgaggc   atg gcc acc gcg gca acc tca ccc gcg ctg aag cgg ctg      49
              Met Ala Thr Ala Ala Thr Ser Pro Ala Leu Lys Arg Leu
                1               5                  10

 gat ctg cgc gac cct gcg gct ctt ttc gag acg cat gga gcg gag gag       97
 Asp Leu Arg Asp Pro Ala Ala Leu Phe Glu Thr His Gly Ala Glu Glu
      15                  20                  25

 atc cgc ggg ctg gag cgc cag gtt cgg gcc gag atc gag cac aag aag      145
 Ile Arg Gly Leu Glu Arg Gln Val Arg Ala Glu Ile Glu His Lys Lys
  30                  35                  40                  45

 gag gag ctg cgg cag atg gtg ggc gaa cgg tac cgc gac ctg atc gag      193
 Glu Glu Leu Arg Gln Met Val Gly Glu Arg Tyr Arg Asp Leu Ile Glu
                  50                  55                  60

 gcg gcc gac acc atc ggc cag atg cgc cgc tgc gcc gtg ggg cta gtg      241
 Ala Ala Asp Thr Ile Gly Gln Met Arg Arg Cys Ala Val Gly Leu Val
              65                  70                  75

 gac gcc gtg aag gcc acc gac cag tac tgc gcc cgc ctc cgc cag gcc      289
 Asp Ala Val Lys Ala Thr Asp Gln Tyr Cys Ala Arg Leu Arg Gln Ala
          80                  85                  90

 ggc tcg gcc gcg ccc cgg cca ccg cgg gcc cag cag cca cag cag cca      337
 Gly Ser Ala Ala Pro Arg Pro Pro Arg Ala Gln Gln Pro Gln Gln Pro
      95                 100                 105

 tcc caa gag aag ttc tac agc atg gct gcc cag atc aag cta ctc tta      385
 Ser Gln Glu Lys Phe Tyr Ser Met Ala Ala Gln Ile Lys Leu Leu Leu
 110                 115                 120                 125

 gaa att ccg gag aag atc tgg agc tcg atg gaa gcc tct cag tgt ctc      433
 Glu Ile Pro Glu Lys Ile Trp Ser Ser Met Glu Ala Ser Gln Cys Leu
                 130                 135                 140

 cac gcc aca cag ctc tac ctg ctc tgc tgc cac ctc cac agc ctg ctc      481
 His Ala Thr Gln Leu Tyr Leu Leu Cys Cys His Leu His Ser Leu Leu
             145                 150                 155

 cag ctg gat tct tct agt tcc cga tac agt ccc gtc ctc tcc cgg ttt      529
 Gln Leu Asp Ser Ser Ser Ser Arg Tyr Ser Pro Val Leu Ser Arg Phe
         160                 165                 170

 cct ata ctc atc cgg cag gtg gcg gcc gca agc cac ttc cgg tca act      577
 Pro Ile Leu Ile Arg Gln Val Ala Ala Ala Ser His Phe Arg Ser Thr
     175                 180                 185

 att ctg cat gaa agc aag atg ttg ctc aaa tgc caa ggt gtg tct gac      625
 Ile Leu His Glu Ser Lys Met Leu Leu Lys Cys Gln Gly Val Ser Asp
 190                 195                 200                 205

 caa gct gtg gcc gag gcc ctg tgc tct ata atg ctc tta gaa gag agt      673
 Gln Ala Val Ala Glu Ala Leu Cys Ser Ile Met Leu Leu Glu Glu Ser
                 210                 215                 220

 tct cct cgc caa gcc ctc aca gac ttc ctg ctg gcc aga aag gca act      721
 Ser Pro Arg Gln Ala Leu Thr Asp Phe Leu Leu Ala Arg Lys Ala Thr
             225                 230                 235

 att cag aaa ctt ctc aac cag cca cac cat ggt gct ggt atc aag gct      769
 Ile Gln Lys Leu Leu Asn Gln Pro His His Gly Ala Gly Ile Lys Ala
         240                 245                 250

 cag att tgc tca tta gtt gag ttg ctg gcc acc act ctg aag caa gct      817
 Gln Ile Cys Ser Leu Val Glu Leu Leu Ala Thr Thr Leu Lys Gln Ala
     255                 260                 265

 cat gcc ctt ttc tac act ttg cca gaa gga ctg ctg cca gat cca gcc      865
 His Ala Leu Phe Tyr Thr Leu Pro Glu Gly Leu Leu Pro Asp Pro Ala
 270                 275                 280                 285

 ctg cca tgt ggc ttg ctc ttc tct act ctg gag acc atc aca ggc cag      913
 Leu Pro Cys Gly Leu Leu Phe Ser Thr Leu Glu Thr Ile Thr Gly Gln
                 290                 295                 300

 cat cct gcc gga aag ggc act ggt gtc ctg cag gaa gag atg aaa ctc      961
 His Pro Ala Gly Lys Gly Thr Gly Val Leu Gln Glu Glu Met Lys Leu
             305                 310                 315

 tgc agc tgg ttt aaa cac ctg cca gca tcc atc gtc gag ttc cag cca     1009
 Cys Ser Trp Phe Lys His Leu Pro Ala Ser Ile Val Glu Phe Gln Pro
         320                 325                 330

 aca ctc cga acc ctt gca cat ccc atc agt cag gaa tac ctg aaa gac     1057
 Thr Leu Arg Thr Leu Ala His Pro Ile Ser Gln Glu Tyr Leu Lys Asp
     335                 340                 345

 acg ctg cag aaa tgg atc cac atg tgt aat gaa gac att aaa aat ggg     1105
 Thr Leu Gln Lys Trp Ile His Met Cys Asn Glu Asp Ile Lys Asn Gly
 350                 355                 360                 365

 atc acc aac ctg ctc atg tac gtg aag agc atg aag ggt ctc gcg gga     1153
 Ile Thr Asn Leu Leu Met Tyr Val Lys Ser Met Lys Gly Leu Ala Gly
                 370                 375                 380

 atc cgg gac gcc atg tgg gag tta ctt acc agt gag tcc acc aat cac     1201
 Ile Arg Asp Ala Met Trp Glu Leu Leu Thr Ser Glu Ser Thr Asn His
             385                 390                 395

 agc tgg gat gtg cta tgt cgg cgg ctt ctg gag aag ccg ctc ttg ttc     1249
 Ser Trp Asp Val Leu Cys Arg Arg Leu Leu Glu Lys Pro Leu Leu Phe
         400                 405                 410

 tgg gaa gat atg atg cag caa ctg ttc ctt gac cga tta cag act ctg     1297
 Trp Glu Asp Met Met Gln Gln Leu Phe Leu Asp Arg Leu Gln Thr Leu
     415                 420                 425

 aca aaa gaa ggc ttt gac tcc atc tcc agt agc tcc aag gag ctc ttg     1345
 Thr Lys Glu Gly Phe Asp Ser Ile Ser Ser Ser Ser Lys Glu Leu Leu
 430                 435                 440                 445

 gtt tca gct ttg cag gaa ctt gaa agc agc acc agc aac tcc cct tca     1393
 Val Ser Ala Leu Gln Glu Leu Glu Ser Ser Thr Ser Asn Ser Pro Ser
                 450                 455                 460

 aat aag cac atc cac ttt gag tac aac atg tcg ctc ttc ctc tgg tct     1441
 Asn Lys His Ile His Phe Glu Tyr Asn Met Ser Leu Phe Leu Trp Ser
             465                 470                 475

 gag agt cct aat gac ctg cct tcc gat gcg gcc tgg gtc agc gtg gca     1489
 Glu Ser Pro Asn Asp Leu Pro Ser Asp Ala Ala Trp Val Ser Val Ala
         480                 485                 490

 aac cgg ggt cag ttt gcc agt agc ggc ctc tcc atg aaa gca caa gcc     1537
 Asn Arg Gly Gln Phe Ala Ser Ser Gly Leu Ser Met Lys Ala Gln Ala
     495                 500                 505

 atc agc cct tgt gta cag aac ttc tgt tct gcc ctg gat tct aag ctg     1585
 Ile Ser Pro Cys Val Gln Asn Phe Cys Ser Ala Leu Asp Ser Lys Leu
 510                 515                 520                 525

 aag gtt aaa cta gat gac ctc ctg gct tac ctc ccc tct gat gac tca     1633
 Lys Val Lys Leu Asp Asp Leu Leu Ala Tyr Leu Pro Ser Asp Asp Ser
                 530                 535                 540

 tca ctg ccc aag gac gtt tct ccc aca cag gcc aag agt tct gcc ttt     1681
 Ser Leu Pro Lys Asp Val Ser Pro Thr Gln Ala Lys Ser Ser Ala Phe
             545                 550                 555

 gac aga tac gca gat gcg ggg acc gtg cag gag atg ctg cgg act cag     1729
 Asp Arg Tyr Ala Asp Ala Gly Thr Val Gln Glu Met Leu Arg Thr Gln
         560                 565                 570

 tcc gtg gca tgc atc aag cac atc gtg gac tgc atc cgg gca gag cta     1777
 Ser Val Ala Cys Ile Lys His Ile Val Asp Cys Ile Arg Ala Glu Leu
     575                 580                 585

 cag agc att gaa gag ggt gtg caa ggg caa cag gat gcc ctc aac agt     1825
 Gln Ser Ile Glu Glu Gly Val Gln Gly Gln Gln Asp Ala Leu Asn Ser
 590                 595                 600                 605

 gcc aag ctg cac tca gtt ctt ttc atg gcc aga ctc tgc cag tcc ctg     1873
 Ala Lys Leu His Ser Val Leu Phe Met Ala Arg Leu Cys Gln Ser Leu
                 610                 615                 620

 gga gag ctg tgc ccc cat ctg aag cag tgc atc ctg gga aaa tca gag     1921
 Gly Glu Leu Cys Pro His Leu Lys Gln Cys Ile Leu Gly Lys Ser Glu
             625                 630                 635

 agc tca gag aaa cca gca agg gag ttt agg gct ctg aga aaa cag gga     1969
 Ser Ser Glu Lys Pro Ala Arg Glu Phe Arg Ala Leu Arg Lys Gln Gly
         640                 645                 650

 aag gtg aaa act cag gaa atc att cct aca cag gcc aag tgg caa gag     2017
 Lys Val Lys Thr Gln Glu Ile Ile Pro Thr Gln Ala Lys Trp Gln Glu
     655                 660                 665

 gtt aaa gaa gta ctc ctc cag cag agc gtg atg ggc tac cag gtc tgg     2065
 Val Lys Glu Val Leu Leu Gln Gln Ser Val Met Gly Tyr Gln Val Trp
 670                 675                 680                 685

 agc agt gca gtt gtg aaa gtt ttg att cat gga ttc acc cag tca tta     2113
 Ser Ser Ala Val Val Lys Val Leu Ile His Gly Phe Thr Gln Ser Leu
                 690                 695                 700

 ctt cta gat gat gct ggc tca gtt ctg gcc aca gcc acc agc tgg gat     2161
 Leu Leu Asp Asp Ala Gly Ser Val Leu Ala Thr Ala Thr Ser Trp Asp
             705                 710                 715

 gag cta gaa att cag gag gag gca gag tct ggc agc agt gtc aca tcc     2209
 Glu Leu Glu Ile Gln Glu Glu Ala Glu Ser Gly Ser Ser Val Thr Ser
         720                 725                 730

 aag atc cga ctc cct gca cag ccg tcc tgg tat gta cag tcc ttc ctg     2257
 Lys Ile Arg Leu Pro Ala Gln Pro Ser Trp Tyr Val Gln Ser Phe Leu
     735                 740                 745

 ttt agt tta tgc cag gaa att aat cgg gtt gga ggc cat gcc ttg cca     2305
 Phe Ser Leu Cys Gln Glu Ile Asn Arg Val Gly Gly His Ala Leu Pro
 750                 755                 760                 765

 aag gtg aca tta cag gag atg ctg aaa agc tgt atg gtt caa gta gta     2353
 Lys Val Thr Leu Gln Glu Met Leu Lys Ser Cys Met Val Gln Val Val
                 770                 775                 780

 gct gcc tat gag aaa ctc tcc gaa gaa aaa cag att aag aaa gaa ggt     2401
 Ala Ala Tyr Glu Lys Leu Ser Glu Glu Lys Gln Ile Lys Lys Glu Gly
             785                 790                 795

 gca ttt cca gtc acc cag aac cgg gcg ctg cag ctg ctt tat gat ctg     2449
 Ala Phe Pro Val Thr Gln Asn Arg Ala Leu Gln Leu Leu Tyr Asp Leu
         800                 805                 810

 cgt tac ctc aac att gtt ctg aca gcc aag ggt gac gag gtg aag agt     2497
 Arg Tyr Leu Asn Ile Val Leu Thr Ala Lys Gly Asp Glu Val Lys Ser
     815                 820                 825

 ggc cgg agc aag cca gac tcc aga att gag aaa gtg act gac cac ctg     2545
 Gly Arg Ser Lys Pro Asp Ser Arg Ile Glu Lys Val Thr Asp His Leu
 830                 835                 840                 845

 gaa gcc ctc att gat cca ttt gac ctg gac gtt ttc acg cca cac ctc     2593
 Glu Ala Leu Ile Asp Pro Phe Asp Leu Asp Val Phe Thr Pro His Leu
                 850                 855                 860

 aac agc aac ctt cat cgc ctg gtg cag cga act tct gtt ctg ttt gga     2641
 Asn Ser Asn Leu His Arg Leu Val Gln Arg Thr Ser Val Leu Phe Gly
             865                 870                 875

 ttg gtg act ggt aca gag aat cag ctc gcc ccc cgg agc agt acg ttc     2689
 Leu Val Thr Gly Thr Glu Asn Gln Leu Ala Pro Arg Ser Ser Thr Phe
         880                 885                 890

 aac tcc caa gaa ccc cat aac atc ctg cca ctg gca tcc agt cag atc     2737
 Asn Ser Gln Glu Pro His Asn Ile Leu Pro Leu Ala Ser Ser Gln Ile
     895                 900                 905

 agg ttt gga ctt ctc cca ctg agc atg aca agc act cga aag gct aaa     2785
 Arg Phe Gly Leu Leu Pro Leu Ser Met Thr Ser Thr Arg Lys Ala Lys
 910                 915                 920                 925

 tca acc aga aac atc gaa aca aaa gct cag gtt ggt gcc aag agc aag     2833
 Ser Thr Arg Asn Ile Glu Thr Lys Ala Gln Val Gly Ala Lys Ser Lys
                 930                 935                 940

 agg ctc atc cgt gga tgg gtc ccc acc tcc cac cga gcc acc cat gat     2881
 Arg Leu Ile Arg Gly Trp Val Pro Thr Ser His Arg Ala Thr His Asp
             945                 950                 955

 cag ctc cct ttt aaa taa ctgatt aagaactgaa tgacaaaatg cactaatgct     2935
 Gln Leu Pro Phe Lys 
         960

 gcttttaatg gcggcgcaat agagaagtac aaggttttac tagcttgagc tactagaagg   2995

 tgtaaaagat gcccgctgac actaccaagt agcctcttaa tagaaatgta gaaaatatac   3055

 aggacagggt ggagatgagc tcttgaattt agtagggtga aagagttaac tgccaacccg   3115

 gcactatcat tgtacttgtt tggagaaaat ctgttttgtt ctggtgatga tggttttatc   3175

 ttccctttta gttgggtggg aagtaacaga aaatttgttt ccccaaaagt ttgacatttt   3235

 cttgttaata cacgtttcat ttcagtacga tgccaactgt taagcctgca ggaatcctcc   3295

 tgggtatttc tgaattgtgc tgtgtgcatg tgtgtttgaa agctcaaaca gcttgtcttc   3355

 ttacagcatc gagttgtttg ctttattgtt agacacaata ttagcagtgt atcctttccg   3415

 tattccctac catcgaaccc attaagatct aaaatccttg tcaagtatct ggctttaaaa   3475

 gttgggagat ggtagtttaa aaaaaaaaa                                     3504




      <210> 198
      <211> 3624
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (11)..(3019)

      <400> 198
 ggcacgaggc   atg gcc acc gcg gca acc tca ccc gcg ctg aag cgg ctg      49
              Met Ala Thr Ala Ala Thr Ser Pro Ala Leu Lys Arg Leu
                1               5                  10

 gat ctg cgc gac cct gcg gct ctt ttc gag acg cat gga gcg gag gag       97
 Asp Leu Arg Asp Pro Ala Ala Leu Phe Glu Thr His Gly Ala Glu Glu
      15                  20                  25

 atc cgc ggg ctg gag cgc cag gtt cgg gcc gag atc gag cac aag aag      145
 Ile Arg Gly Leu Glu Arg Gln Val Arg Ala Glu Ile Glu His Lys Lys
  30                  35                  40                  45

 gag gag ctg cgg cag atg gtg ggc gaa cgg tac cgc gac ctg atc gag      193
 Glu Glu Leu Arg Gln Met Val Gly Glu Arg Tyr Arg Asp Leu Ile Glu
                  50                  55                  60

 gcg gcc gac acc atc ggc cag atg cgc cgc tgc gcc gtg ggg cta gtg      241
 Ala Ala Asp Thr Ile Gly Gln Met Arg Arg Cys Ala Val Gly Leu Val
              65                  70                  75

 gac gcc gtg aag gcc acc gac cag tac tgc gcc cgc ctc cgc cag gcc      289
 Asp Ala Val Lys Ala Thr Asp Gln Tyr Cys Ala Arg Leu Arg Gln Ala
          80                  85                  90

 ggc tcg gcc gcg ccc cgg cca ccg cgg gcc cag cag cca cag cag cca      337
 Gly Ser Ala Ala Pro Arg Pro Pro Arg Ala Gln Gln Pro Gln Gln Pro
      95                 100                 105

 tcc caa gag aag ttc tac agc atg gct gcc cag atc aag cta ctc tta      385
 Ser Gln Glu Lys Phe Tyr Ser Met Ala Ala Gln Ile Lys Leu Leu Leu
 110                 115                 120                 125

 gaa att ccg gag aag atc tgg agc tcg atg gaa gcc tct cag tgt ctc      433
 Glu Ile Pro Glu Lys Ile Trp Ser Ser Met Glu Ala Ser Gln Cys Leu
                 130                 135                 140

 cac gcc aca cag ctc tac ctg ctc tgc tgc cac ctc cac agc ctg ctc      481
 His Ala Thr Gln Leu Tyr Leu Leu Cys Cys His Leu His Ser Leu Leu
             145                 150                 155

 cag ctg gat tct tct agt tcc cga tac agt ccc gtc ctc tcc cgg ttt      529
 Gln Leu Asp Ser Ser Ser Ser Arg Tyr Ser Pro Val Leu Ser Arg Phe
         160                 165                 170

 cct ata ctc atc cgg cag gtg gcg gcc gca agc cac ttc cgg tca act      577
 Pro Ile Leu Ile Arg Gln Val Ala Ala Ala Ser His Phe Arg Ser Thr
     175                 180                 185

 att ctg cat gaa agc aag atg ttg ctc aaa tgc caa ggt gtg tct gac      625
 Ile Leu His Glu Ser Lys Met Leu Leu Lys Cys Gln Gly Val Ser Asp
 190                 195                 200                 205

 caa gct gtg gcc gag gcc ctg tgc tct ata atg ctc tta gaa gag agt      673
 Gln Ala Val Ala Glu Ala Leu Cys Ser Ile Met Leu Leu Glu Glu Ser
                 210                 215                 220

 tct cct cgc caa gcc ctc aca gac ttc ctg ctg gcc aga aag gca act      721
 Ser Pro Arg Gln Ala Leu Thr Asp Phe Leu Leu Ala Arg Lys Ala Thr
             225                 230                 235

 att cag aaa ctt ctc aac cag cca cac cat ggt gct ggt atc aag gct      769
 Ile Gln Lys Leu Leu Asn Gln Pro His His Gly Ala Gly Ile Lys Ala
         240                 245                 250

 cag att tgc tca tta gtt gag ttg ctg gcc acc act ctg aag caa gct      817
 Gln Ile Cys Ser Leu Val Glu Leu Leu Ala Thr Thr Leu Lys Gln Ala
     255                 260                 265

 cat gcc ctt ttc tac act ttg cca gaa gga ctg ctg cca gat cca gcc      865
 His Ala Leu Phe Tyr Thr Leu Pro Glu Gly Leu Leu Pro Asp Pro Ala
 270                 275                 280                 285

 ctg cca tgt ggc ttg ctc ttc tct act ctg gag acc atc aca ggc cag      913
 Leu Pro Cys Gly Leu Leu Phe Ser Thr Leu Glu Thr Ile Thr Gly Gln
                 290                 295                 300

 cat cct gcc gct gtg gga atg gat gac atc atc agt aag gag atg aca      961
 His Pro Ala Ala Val Gly Met Asp Asp Ile Ile Ser Lys Glu Met Thr
             305                 310                 315

 gag gac tct gcc tta tgg aac tcc aga aat cca agg tca aat gga ggt     1009
 Glu Asp Ser Ala Leu Trp Asn Ser Arg Asn Pro Arg Ser Asn Gly Gly
         320                 325                 330

 gtc agc aaa att gac aaa gga gat aca gcc aaa gga aag ggc act ggt     1057
 Val Ser Lys Ile Asp Lys Gly Asp Thr Ala Lys Gly Lys Gly Thr Gly
     335                 340                 345

 gtc ctg cag gaa gag atg aaa ctc tgc agc tgg ttt aaa cac ctg cca     1105
 Val Leu Gln Glu Glu Met Lys Leu Cys Ser Trp Phe Lys His Leu Pro
 350                 355                 360                 365

 gca tcc atc gtc gag ttc cag cca aca ctc cga acc ctt gca cat ccc     1153
 Ala Ser Ile Val Glu Phe Gln Pro Thr Leu Arg Thr Leu Ala His Pro
                 370                 375                 380

 atc agt cag gaa tac ctg aaa gac acg ctg cag aaa tgg atc cac atg     1201
 Ile Ser Gln Glu Tyr Leu Lys Asp Thr Leu Gln Lys Trp Ile His Met
             385                 390                 395

 tgt aat gaa gac att aaa aat ggg atc acc aac ctg ctc atg tac gtg     1249
 Cys Asn Glu Asp Ile Lys Asn Gly Ile Thr Asn Leu Leu Met Tyr Val
         400                 405                 410

 aag agc atg aag ggt ctc gcg gga atc cgg gac gcc atg tgg gag tta     1297
 Lys Ser Met Lys Gly Leu Ala Gly Ile Arg Asp Ala Met Trp Glu Leu
     415                 420                 425

 ctt acc agt gag tcc acc aat cac agc tgg gat gtg cta tgt cgg cgg     1345
 Leu Thr Ser Glu Ser Thr Asn His Ser Trp Asp Val Leu Cys Arg Arg
 430                 435                 440                 445

 ctt ctg gag aag ccg ctc ttg ttc tgg gaa gat atg atg cag caa ctg     1393
 Leu Leu Glu Lys Pro Leu Leu Phe Trp Glu Asp Met Met Gln Gln Leu
                 450                 455                 460

 ttc ctt gac cga tta cag act ctg aca aaa gaa ggc ttt gac tcc atc     1441
 Phe Leu Asp Arg Leu Gln Thr Leu Thr Lys Glu Gly Phe Asp Ser Ile
             465                 470                 475

 tcc agt agc tcc aag gag ctc ttg gtt tca gct ttg cag gaa ctt gaa     1489
 Ser Ser Ser Ser Lys Glu Leu Leu Val Ser Ala Leu Gln Glu Leu Glu
         480                 485                 490

 agc agc acc agc aac tcc cct tca aat aag cac atc cac ttt gag tac     1537
 Ser Ser Thr Ser Asn Ser Pro Ser Asn Lys His Ile His Phe Glu Tyr
     495                 500                 505

 aac atg tcg ctc ttc ctc tgg tct gag agt cct aat gac ctg cct tcc     1585
 Asn Met Ser Leu Phe Leu Trp Ser Glu Ser Pro Asn Asp Leu Pro Ser
 510                 515                 520                 525

 gat gcg gcc tgg gtc agc gtg gca aac cgg ggt cag ttt gcc agt agc     1633
 Asp Ala Ala Trp Val Ser Val Ala Asn Arg Gly Gln Phe Ala Ser Ser
                 530                 535                 540

 ggc ctc tcc atg aaa gca caa gcc atc agc cct tgt gta cag aac ttc     1681
 Gly Leu Ser Met Lys Ala Gln Ala Ile Ser Pro Cys Val Gln Asn Phe
             545                 550                 555

 tgt tct gcc ctg gat tct aag ctg aag gtt aaa cta gat gac ctc ctg     1729
 Cys Ser Ala Leu Asp Ser Lys Leu Lys Val Lys Leu Asp Asp Leu Leu
         560                 565                 570

 gct tac ctc ccc tct gat gac tca tca ctg ccc aag gac gtt tct ccc     1777
 Ala Tyr Leu Pro Ser Asp Asp Ser Ser Leu Pro Lys Asp Val Ser Pro
     575                 580                 585

 aca cag gcc aag agt tct gcc ttt gac aga tac gca gat gcg ggg acc     1825
 Thr Gln Ala Lys Ser Ser Ala Phe Asp Arg Tyr Ala Asp Ala Gly Thr
 590                 595                 600                 605

 gtg cag gag atg ctg cgg act cag tcc gtg gca tgc atc aag cac atc     1873
 Val Gln Glu Met Leu Arg Thr Gln Ser Val Ala Cys Ile Lys His Ile
                 610                 615                 620

 gtg gac tgc atc cgg gca gag cta cag agc att gaa gag ggt gtg caa     1921
 Val Asp Cys Ile Arg Ala Glu Leu Gln Ser Ile Glu Glu Gly Val Gln
             625                 630                 635

 ggg caa cag gat gcc ctc aac agt gcc aag ctg cac tca gtt ctt ttc     1969
 Gly Gln Gln Asp Ala Leu Asn Ser Ala Lys Leu His Ser Val Leu Phe
         640                 645                 650

 atg gcc aga ctc tgc cag tcc ctg gga gag ctg tgc ccc cat ctg aag     2017
 Met Ala Arg Leu Cys Gln Ser Leu Gly Glu Leu Cys Pro His Leu Lys
     655                 660                 665

 cag tgc atc ctg gga aaa tca gag agc tca gag aaa cca gca agg gag     2065
 Gln Cys Ile Leu Gly Lys Ser Glu Ser Ser Glu Lys Pro Ala Arg Glu
 670                 675                 680                 685

 ttt agg gct ctg aga aaa cag gga aag gtg aaa act cag gaa atc att     2113
 Phe Arg Ala Leu Arg Lys Gln Gly Lys Val Lys Thr Gln Glu Ile Ile
                 690                 695                 700

 cct aca cag gcc aag tgg caa gag gtt aaa gaa gta ctc ctc cag cag     2161
 Pro Thr Gln Ala Lys Trp Gln Glu Val Lys Glu Val Leu Leu Gln Gln
             705                 710                 715

 agc gtg atg ggc tac cag gtc tgg agc agt gca gtt gtg aaa gtt ttg     2209
 Ser Val Met Gly Tyr Gln Val Trp Ser Ser Ala Val Val Lys Val Leu
         720                 725                 730

 att cat gga ttc acc cag tca tta ctt cta gat gat gct ggc tca gtt     2257
 Ile His Gly Phe Thr Gln Ser Leu Leu Leu Asp Asp Ala Gly Ser Val
     735                 740                 745

 ctg gcc aca gcc acc agc tgg gat gag cta gaa att cag gag gag gca     2305
 Leu Ala Thr Ala Thr Ser Trp Asp Glu Leu Glu Ile Gln Glu Glu Ala
 750                 755                 760                 765

 gag tct ggc agc agt gtc aca tcc aag atc cga ctc cct gca cag ccg     2353
 Glu Ser Gly Ser Ser Val Thr Ser Lys Ile Arg Leu Pro Ala Gln Pro
                 770                 775                 780

 tcc tgg tat gta cag tcc ttc ctg ttt agt tta tgc cag gaa att aat     2401
 Ser Trp Tyr Val Gln Ser Phe Leu Phe Ser Leu Cys Gln Glu Ile Asn
             785                 790                 795

 cgg gtt gga ggc cat gcc ttg cca aag gtg aca tta cag gag atg ctg     2449
 Arg Val Gly Gly His Ala Leu Pro Lys Val Thr Leu Gln Glu Met Leu
         800                 805                 810

 aaa agc tgt atg gtt caa gta gta gct gcc tat gag aaa ctc tcc gaa     2497
 Lys Ser Cys Met Val Gln Val Val Ala Ala Tyr Glu Lys Leu Ser Glu
     815                 820                 825

 gaa aaa cag att aag aaa gaa ggt gca ttt cca gtc acc cag aac cgg     2545
 Glu Lys Gln Ile Lys Lys Glu Gly Ala Phe Pro Val Thr Gln Asn Arg
 830                 835                 840                 845

 gcg ctg cag ctg ctt tat gat ctg cgt tac ctc aac att gtt ctg aca     2593
 Ala Leu Gln Leu Leu Tyr Asp Leu Arg Tyr Leu Asn Ile Val Leu Thr
                 850                 855                 860

 gcc aag ggt gac gag gtg aag agt ggc cgg agc aag cca gac tcc aga     2641
 Ala Lys Gly Asp Glu Val Lys Ser Gly Arg Ser Lys Pro Asp Ser Arg
             865                 870                 875

 att gag aaa gtg act gac cac ctg gaa gcc ctc att gat cca ttt gac     2689
 Ile Glu Lys Val Thr Asp His Leu Glu Ala Leu Ile Asp Pro Phe Asp
         880                 885                 890

 ctg gac gtt ttc acg cca cac ctc aac agc aac ctt cat cgc ctg gtg     2737
 Leu Asp Val Phe Thr Pro His Leu Asn Ser Asn Leu His Arg Leu Val
     895                 900                 905

 cag cga act tct gtt ctg ttt gga ttg gtg act ggt aca gag aat cag     2785
 Gln Arg Thr Ser Val Leu Phe Gly Leu Val Thr Gly Thr Glu Asn Gln
 910                 915                 920                 925

 ctc gcc ccc cgg agc agt acg ttc aac tcc caa gaa ccc cat aac atc     2833
 Leu Ala Pro Arg Ser Ser Thr Phe Asn Ser Gln Glu Pro His Asn Ile
                 930                 935                 940

 ctg cca ctg gca tcc agt cag atc agg ttt gga ctt ctc cca ctg agc     2881
 Leu Pro Leu Ala Ser Ser Gln Ile Arg Phe Gly Leu Leu Pro Leu Ser
             945                 950                 955

 atg aca agc act cga aag gct aaa tca acc aga aac atc gaa aca aaa     2929
 Met Thr Ser Thr Arg Lys Ala Lys Ser Thr Arg Asn Ile Glu Thr Lys
         960                 965                 970

 gct cag gtt ggt gcc aag agc aag agg ctc atc cgt gga tgg gtc ccc     2977
 Ala Gln Val Gly Ala Lys Ser Lys Arg Leu Ile Arg Gly Trp Val Pro
     975                 980                 985

 acc tcc cac cga gcc acc cat gat cag ctc cct ttt aaa taa ctgatta     3026
 Thr Ser His Arg Ala Thr His Asp Gln Leu Pro Phe Lys 
 990                 995                1000

 agaactgaat gacaaaatgc actaatgctg cttttaatgg cggcgcaata gagaagtaca   3086

 aggttttact agcttgagct actagaaggt gtaaaagatg cccgctgaca ctaccaagta   3146

 gcctcttaat agaaatgtag aaaatataca ggacagggtg gagatgagct cttgaattta   3206

 gtagggtgaa agagttaact gccaacccgg cactatcatt gtacttgttt ggagaaaatc   3266

 tgttttgttc tggtgatgat ggttttatct tcccttttag ttgggtggga agtaacagaa   3326

 aatttgtttc cccaaaagtt tgacattttc ttgttaatac acgtttcatt tcagtacgat   3386

 gccaactgtt aagcctgcag gaatcctcct gggtatttct gaattgtgct gtgtgcatgt   3446

 gtgtttgaaa gctcaaacag cttgtcttct tacagcatcg agttgtttgc tttattgtta   3506

 gacacaatat tagcagtgta tcctttccgt attccctacc atcgaaccca ttaagatcta   3566

 aaatccttgt caagtatctg gctttaaaag ttgggagatg gtagtttaaa aaaaaaaa     3624




      <210> 199
      <211> 1080
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (19)..(789)

      <400> 199
 aaccctgaaa ggctcgcg  atg cct cta cac aag tat ccc gtg tgg ctc tgg      51
                      Met Pro Leu His Lys Tyr Pro Val Trp Leu Trp
                        1               5                  10

 aag cgg ctg cag ctg cgg gag ggc atc tgt tcc cgc ctg ccc ggc cac       99
 Lys Arg Leu Gln Leu Arg Glu Gly Ile Cys Ser Arg Leu Pro Gly His
              15                  20                  25

 tac ctg cgc tcc ctg gag gag gag cgg acg ccc act ccc gtg cac tat      147
 Tyr Leu Arg Ser Leu Glu Glu Glu Arg Thr Pro Thr Pro Val His Tyr
          30                  35                  40

 agg cct cat ggg gcc aag ttc aag atc aac ccc aag aac ggg cag cgg      195
 Arg Pro His Gly Ala Lys Phe Lys Ile Asn Pro Lys Asn Gly Gln Arg
      45                  50                  55

 gag cgt gtg gag gac gtg ccc att ccc atc tac ttt ccc ccc gaa tcc      243
 Glu Arg Val Glu Asp Val Pro Ile Pro Ile Tyr Phe Pro Pro Glu Ser
  60                  65                  70                  75

 cag cgg ggg ttg tgg ggc ggc gag ggc tgg atc ctg ggc caa ata tat      291
 Gln Arg Gly Leu Trp Gly Gly Glu Gly Trp Ile Leu Gly Gln Ile Tyr
                  80                  85                  90

 gcc aac aac gac aag ctc tcc aag agg ctg aag aaa gtg tgg aag cca      339
 Ala Asn Asn Asp Lys Leu Ser Lys Arg Leu Lys Lys Val Trp Lys Pro
              95                 100                 105

 cag ctg ttt gag cga gag ttc tac agt gag atc ctg gac aag aag ttc      387
 Gln Leu Phe Glu Arg Glu Phe Tyr Ser Glu Ile Leu Asp Lys Lys Phe
         110                 115                 120

 aca gtg act gtg acc atg cgg acc ctg gac ctc atc gat gag gct tac      435
 Thr Val Thr Val Thr Met Arg Thr Leu Asp Leu Ile Asp Glu Ala Tyr
     125                 130                 135

 ggg ctc gac ttt tac atc ctc aag acc ccg aag gag gac ctg tgc tcc      483
 Gly Leu Asp Phe Tyr Ile Leu Lys Thr Pro Lys Glu Asp Leu Cys Ser
 140                 145                 150                 155

 aag ttt ggg atg gac ctg aag cga ggg atg cag ctg cgg ctt gcc cgg      531
 Lys Phe Gly Met Asp Leu Lys Arg Gly Met Gln Leu Arg Leu Ala Arg
                 160                 165                 170

 cag gac ccc cag ctg cac ccc gag gac ccc gag cgg cgg gca gcc atc      579
 Gln Asp Pro Gln Leu His Pro Glu Asp Pro Glu Arg Arg Ala Ala Ile
             175                 180                 185

 tac gac aag tac aag gaa ttt gcc atc cca gag gag gag gca gag tgg      627
 Tyr Asp Lys Tyr Lys Glu Phe Ala Ile Pro Glu Glu Glu Ala Glu Trp
         190                 195                 200

 gtg ggc ctc acg ctg gag gag gcc att gag aag cag aga ctt ttg gag      675
 Val Gly Leu Thr Leu Glu Glu Ala Ile Glu Lys Gln Arg Leu Leu Glu
     205                 210                 215

 gag aag gac cct gta ccc ctg ttc aag atc tat gtg gcg gag ctg atc      723
 Glu Lys Asp Pro Val Pro Leu Phe Lys Ile Tyr Val Ala Glu Leu Ile
 220                 225                 230                 235

 cag cag ctg cag cag cag gca ctg tca gag ccg gcg gtg gtg cag aag      771
 Gln Gln Leu Gln Gln Gln Ala Leu Ser Glu Pro Ala Val Val Gln Lys
                 240                 245                 250

 aga gcc agt ggc cag tga ccacac agctcctcca tgcctgacca acaggcccag      825
 Arg Ala Ser Gly Gln 
             255

 ctttccctgc caggcccttt gcactgagga cacagatccc ggggagctgt gagggccacc    885

 ggtgggcagt gggtggatcc tggtttcgtg tgctgcccat gcaccttcca gcccggggcc    945

 agcttggcag ggatccccag gaggcctggg ccgcccagag gctcctctca ggctgggccc   1005

 cgacgtttgc ggcagtgttc cttgtgcccg tggggccggg agcgagtaaa gtctgggcca   1065

 ggcaaaaaaa aaaaa                                                    1080




      <210> 200
      <211> 4387
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (851)..(4387)

      <400> 200
 atgcagcgcc ggaattcccg ggtcgacgat ttcgtccggt tcctgaaagt tgcaagaatg     60

 ggggcggaag gtgttatgtc tcctaagtct tacaggcgtg ggaggacggg gaagtaggat    120

 gtggttttca ccgatactta gacctcctag acacatcccc aacccctgcc ctgggtgtgg    180

 agtgggtggc tgagtctgag gccgggaggg tctctcactc tagggtggat gggatgaggg    240

 ccctagcgtg ggaacctcac ctgccctgct gaaggcctgg gtgctaaggt gctgtaaaga    300

 caggggcagg cctgtgccca ccttctgtct ccccacaggc tctgttcact tgcagatacc    360

 atacagagcc ttcattcatt cattcattga caatgaatgt ggggtgcccc tctgtaacca    420

 gacctggatc aagacgcctg cctccccaga ctcagccact gcccacttca gcttctgccg    480

 gaccctcctg gagcacacgg tgtcagctga gagcatcccc tgccacttgc ctcggacacc    540

 tggcaccagc ctcacgtggc atgactcccg cagccagagg gcggccagca gcaggccaat    600

 caagctcctg cagcagcccg gcacagacac cccccagggc cggctgtact ctgaccacta    660

 tggcctgtac catacaagcc cctcgctggg tggcctgacc cggcccgtgg tcctgtggag    720

 tcagcaggac gtctgcaagt ggctcaagaa gcactgtccc cacaactacc tcgtctacgt    780

 ggaggccttc tcccagcatg ccatcaccgg ccgggcactg ctgcggctga atgcggagaa    840

 gctgcagcgg   atg ggg ctg gcc cag gag gcc cag agg cag gag gtg ctg     889
              Met Gly Leu Ala Gln Glu Ala Gln Arg Gln Glu Val Leu
                1               5                  10

 cag cag gtg ctc cgc ctg cag gtg cgt gag gag ggg cgg agc ctg cag      937
 Gln Gln Val Leu Arg Leu Gln Val Arg Glu Glu Gly Arg Ser Leu Gln
      15                  20                  25

 ctg ctc agc caa gaa aca cat ggg aca cgg cac atc ccc ggt gca cac      985
 Leu Leu Ser Gln Glu Thr His Gly Thr Arg His Ile Pro Gly Ala His
  30                  35                  40                  45

 aaa cac act gta ttc cac gac acc ctg gca tgt aga tgc tca cag aaa     1033
 Lys His Thr Val Phe His Asp Thr Leu Ala Cys Arg Cys Ser Gln Lys
                  50                  55                  60

 aca gcc gtc cct cac cag cac cct gac act gag aca tgc cgc agc ctg     1081
 Thr Ala Val Pro His Gln His Pro Asp Thr Glu Thr Cys Arg Ser Leu
              65                  70                  75

 gac aca tgg ata ctg aaa tcc aga cac atc gtc ccc agt cct gtg ctg     1129
 Asp Thr Trp Ile Leu Lys Ser Arg His Ile Val Pro Ser Pro Val Leu
          80                  85                  90

 tca gtg ccc cgc cac ctc cag acc act cag ccc aca ccg gac ccc agt     1177
 Ser Val Pro Arg His Leu Gln Thr Thr Gln Pro Thr Pro Asp Pro Ser
      95                 100                 105

 gcc ccc tgc ctg cag aag ccc aag ctg tgg ggc aga gaa ggc cct ggc     1225
 Ala Pro Cys Leu Gln Lys Pro Lys Leu Trp Gly Arg Glu Gly Pro Gly
 110                 115                 120                 125

 act ggt tca gaa cca ctg ccc cca gag ctg gga aag ggt gac cca atg     1273
 Thr Gly Ser Glu Pro Leu Pro Pro Glu Leu Gly Lys Gly Asp Pro Met
                 130                 135                 140

 gag tgc atc acc ttc ggc atc atc ttc gca gct gtg ggg cta cgc aca     1321
 Glu Cys Ile Thr Phe Gly Ile Ile Phe Ala Ala Val Gly Leu Arg Thr
             145                 150                 155

 ctg tgg agc tgc gta cac tgt aga gct gcg tgt tgg gaa ggg ggt ctg     1369
 Leu Trp Ser Cys Val His Cys Arg Ala Ala Cys Trp Glu Gly Gly Leu
         160                 165                 170

 gaa gtt gag atg acg gat cct ttc tgc gtt gga ggc cgt cgg ctc ccg     1417
 Glu Val Glu Met Thr Asp Pro Phe Cys Val Gly Gly Arg Arg Leu Pro
     175                 180                 185

 ggg tcc agc aag agt ggt ccc ggg aag gat ggc agc cga aag gag gtc     1465
 Gly Ser Ser Lys Ser Gly Pro Gly Lys Asp Gly Ser Arg Lys Glu Val
 190                 195                 200                 205

 cga ctt cca atg ctg cat gac cca ccg aag atg ggg atg ccg gtg gtc     1513
 Arg Leu Pro Met Leu His Asp Pro Pro Lys Met Gly Met Pro Val Val
                 210                 215                 220

 cgt ggt gga cag aca gtg ccc ggc cag gcc cct ctc tgc ttt gac ccg     1561
 Arg Gly Gly Gln Thr Val Pro Gly Gln Ala Pro Leu Cys Phe Asp Pro
             225                 230                 235

 gga agt cca gcc agt gac aag aca gaa ggg aag aaa aag ggg cgg cca     1609
 Gly Ser Pro Ala Ser Asp Lys Thr Glu Gly Lys Lys Lys Gly Arg Pro
         240                 245                 250

 aaa gcc gag aac cag gcc ctc cga gac att cct ctc tcc ctg atg aac     1657
 Lys Ala Glu Asn Gln Ala Leu Arg Asp Ile Pro Leu Ser Leu Met Asn
     255                 260                 265

 gac tgg aag gat gag ttc aag gca cac tcg agg gtg aag tgt cca aac     1705
 Asp Trp Lys Asp Glu Phe Lys Ala His Ser Arg Val Lys Cys Pro Asn
 270                 275                 280                 285

 tca ggg tgc tgg ctg gag ttc ccc agc atc tac ggg ctc aag tac cat     1753
 Ser Gly Cys Trp Leu Glu Phe Pro Ser Ile Tyr Gly Leu Lys Tyr His
                 290                 295                 300

 tac cag cgg tgc caa ggg ggt gcc atc tca gat cgc ctg gcc ttc ccc     1801
 Tyr Gln Arg Cys Gln Gly Gly Ala Ile Ser Asp Arg Leu Ala Phe Pro
             305                 310                 315

 tgc ccc ttc tgc gag gcc gca ttc acc tct aag acc cag ctg gag aaa     1849
 Cys Pro Phe Cys Glu Ala Ala Phe Thr Ser Lys Thr Gln Leu Glu Lys
         320                 325                 330

 cac cgg atc tgg aac cac atg gac cga ccc ctg cct gcc tcc aag cct     1897
 His Arg Ile Trp Asn His Met Asp Arg Pro Leu Pro Ala Ser Lys Pro
     335                 340                 345

 ggg ccc atc agc agg ccg gtc acc atc agc cgg cct gtt ggg gtc agc     1945
 Gly Pro Ile Ser Arg Pro Val Thr Ile Ser Arg Pro Val Gly Val Ser
 350                 355                 360                 365

 aag ccc atc gga gtg agc aaa cct gtc act att ggc aaa cct gtg ggt     1993
 Lys Pro Ile Gly Val Ser Lys Pro Val Thr Ile Gly Lys Pro Val Gly
                 370                 375                 380

 gtc agc aaa ccc att ggc atc agc aag cca gtc tcg gtc ggc aga ccc     2041
 Val Ser Lys Pro Ile Gly Ile Ser Lys Pro Val Ser Val Gly Arg Pro
             385                 390                 395

 atg cca gtc acc aag gcc atc ccg gtc act agg ccc gtg cca gtc acc     2089
 Met Pro Val Thr Lys Ala Ile Pro Val Thr Arg Pro Val Pro Val Thr
         400                 405                 410

 aaa cct gtc aca gtc agc agg ccc atg ccc gtc acc aag gcc atg ccg     2137
 Lys Pro Val Thr Val Ser Arg Pro Met Pro Val Thr Lys Ala Met Pro
     415                 420                 425

 gtc acc aaa ccc atc aca gtc acc aag tct gtg ccg gtc acc aaa ccc     2185
 Val Thr Lys Pro Ile Thr Val Thr Lys Ser Val Pro Val Thr Lys Pro
 430                 435                 440                 445

 gta cct gtc acc aaa ccc att acg gta aca aag ctt gtg aca gtt acg     2233
 Val Pro Val Thr Lys Pro Ile Thr Val Thr Lys Leu Val Thr Val Thr
                 450                 455                 460

 aaa ccc gtg ccg gtc acc aag cca gtg aca gtc agc agg ccc att gtg     2281
 Lys Pro Val Pro Val Thr Lys Pro Val Thr Val Ser Arg Pro Ile Val
             465                 470                 475

 gtc agc aag ccg gtg aca gtc agc agg ccc att gct atc agc aga cac     2329
 Val Ser Lys Pro Val Thr Val Ser Arg Pro Ile Ala Ile Ser Arg His
         480                 485                 490

 aca ccg ccc tgc aaa atg gtg ctg ctg acc agg tcg gag aac aaa gca     2377
 Thr Pro Pro Cys Lys Met Val Leu Leu Thr Arg Ser Glu Asn Lys Ala
     495                 500                 505

 cct cgt gcc aca ggg agg aac agt ggt aag aaa agg gct gcg gac agc     2425
 Pro Arg Ala Thr Gly Arg Asn Ser Gly Lys Lys Arg Ala Ala Asp Ser
 510                 515                 520                 525

 ctg gac acc tgc cca att cca ccc aag cag gcc agg cca gag aat ggg     2473
 Leu Asp Thr Cys Pro Ile Pro Pro Lys Gln Ala Arg Pro Glu Asn Gly
                 530                 535                 540

 gag tac ggc ccc tcc tcc atg ggc cag agc tcg gcc ttc cag ctg agt     2521
 Glu Tyr Gly Pro Ser Ser Met Gly Gln Ser Ser Ala Phe Gln Leu Ser
             545                 550                 555

 gca gac acc agc agt ggc tcc ttg tcg cca ggc agc agg ccg tca ggg     2569
 Ala Asp Thr Ser Ser Gly Ser Leu Ser Pro Gly Ser Arg Pro Ser Gly
         560                 565                 570

 ggc atg gag gca ctg aag gct gca ggc cct gcg tcc ccg cct gag gag     2617
 Gly Met Glu Ala Leu Lys Ala Ala Gly Pro Ala Ser Pro Pro Glu Glu
     575                 580                 585

 gac ccg gag cgc aca aag cac agc ctg gtc aaa gct gag gac aag gcc     2665
 Asp Pro Glu Arg Thr Lys His Ser Leu Val Lys Ala Glu Asp Lys Ala
 590                 595                 600                 605

 cga gtt cac cgc tcc aag aag cag gag ggg cca ggc cct gag gac gcc     2713
 Arg Val His Arg Ser Lys Lys Gln Glu Gly Pro Gly Pro Glu Asp Ala
                 610                 615                 620

 cgg aag aag gtg cca gct gcc ccc atc act gtc agc aag gag gca ccg     2761
 Arg Lys Lys Val Pro Ala Ala Pro Ile Thr Val Ser Lys Glu Ala Pro
             625                 630                 635

 gcc cct gtg gcc cac cca gct cca ggt ggc cct gaa gag cag tgg cag     2809
 Ala Pro Val Ala His Pro Ala Pro Gly Gly Pro Glu Glu Gln Trp Gln
         640                 645                 650

 agg gcc atc cat gag cgc ggg gaa gcc gtc tgc ccc acc tgc aac gtg     2857
 Arg Ala Ile His Glu Arg Gly Glu Ala Val Cys Pro Thr Cys Asn Val
     655                 660                 665

 gtc acc cgg aag act ctc gtg ggg ctt aag aag cac atg gag gtg tgt     2905
 Val Thr Arg Lys Thr Leu Val Gly Leu Lys Lys His Met Glu Val Cys
 670                 675                 680                 685

 cag aag ctt cag gat gca ctc aag tgc cag cac tgc cgg aag cag ttc     2953
 Gln Lys Leu Gln Asp Ala Leu Lys Cys Gln His Cys Arg Lys Gln Phe
                 690                 695                 700

 aag tcc aaa gcc ggc ctc aac tac cac act atg gcc gag cac agt gcc     3001
 Lys Ser Lys Ala Gly Leu Asn Tyr His Thr Met Ala Glu His Ser Ala
             705                 710                 715

 aag ccc tct gac gcc gag gcc tcc gaa ggg ggc gag cag gag gag cgc     3049
 Lys Pro Ser Asp Ala Glu Ala Ser Glu Gly Gly Glu Gln Glu Glu Arg
         720                 725                 730

 gag agg ctg cgc aag gtg ctg aag cag atg gga cgg ctg cgc tgc ccc     3097
 Glu Arg Leu Arg Lys Val Leu Lys Gln Met Gly Arg Leu Arg Cys Pro
     735                 740                 745

 cag gag ggt tgc ggg gct gcc ttc tcc agc ctc atg ggc tac cag tac     3145
 Gln Glu Gly Cys Gly Ala Ala Phe Ser Ser Leu Met Gly Tyr Gln Tyr
 750                 755                 760                 765

 cac cag cgg cgc tgc ggg aag ccg ccc tgc gag gtg gac agc ccc tcc     3193
 His Gln Arg Arg Cys Gly Lys Pro Pro Cys Glu Val Asp Ser Pro Ser
                 770                 775                 780

 ttc ccc tgc acc cac tgt ggc aag acg tac cga tcc aag gct ggc cac     3241
 Phe Pro Cys Thr His Cys Gly Lys Thr Tyr Arg Ser Lys Ala Gly His
             785                 790                 795

 gac tac cac gtg cgc tcg gag cac acg gcc ccc ccc cct gag gag ccc     3289
 Asp Tyr His Val Arg Ser Glu His Thr Ala Pro Pro Pro Glu Glu Pro
         800                 805                 810

 aca gac aag tcc cct gag gct gag gac ccg ctg ggt gtg gag cgg acc     3337
 Thr Asp Lys Ser Pro Glu Ala Glu Asp Pro Leu Gly Val Glu Arg Thr
     815                 820                 825

 cca agc ggg cgt gtc cgc cgc acg tcg gcc cag gtg gcg gtg ttc cac     3385
 Pro Ser Gly Arg Val Arg Arg Thr Ser Ala Gln Val Ala Val Phe His
 830                 835                 840                 845

 ctg cag gag ata gcg gag gac gag ctg gcc cgc gac tgg acc aag cgg     3433
 Leu Gln Glu Ile Ala Glu Asp Glu Leu Ala Arg Asp Trp Thr Lys Arg
                 850                 855                 860

 cgc atg aag gat gac ctt gtg ccc gag acc gca cgg ctc aac tac act     3481
 Arg Met Lys Asp Asp Leu Val Pro Glu Thr Ala Arg Leu Asn Tyr Thr
             865                 870                 875

 cga cca ggg ctc ccc acg ctg aac ccc cag ctg cta gag gca tgg aag     3529
 Arg Pro Gly Leu Pro Thr Leu Asn Pro Gln Leu Leu Glu Ala Trp Lys
         880                 885                 890

 aat gaa gtg aag gag aaa ggc cac gtc aac tgt ccc aac gac gtg agc     3577
 Asn Glu Val Lys Glu Lys Gly His Val Asn Cys Pro Asn Asp Val Ser
     895                 900                 905

 gga ggc agc cgg tgc tgt gaa gcc atc tac tcc agc gtg tcc gga ctc     3625
 Gly Gly Ser Arg Cys Cys Glu Ala Ile Tyr Ser Ser Val Ser Gly Leu
 910                 915                 920                 925

 aag gct cat ctc gcc agc tgc agt aag ggg gcc cac ctg gca ggg aag     3673
 Lys Ala His Leu Ala Ser Cys Ser Lys Gly Ala His Leu Ala Gly Lys
                 930                 935                 940

 tac cgc tgt ctg ctg tgt ccg aag gag ttc agt tct gag agt ggc gtc     3721
 Tyr Arg Cys Leu Leu Cys Pro Lys Glu Phe Ser Ser Glu Ser Gly Val
             945                 950                 955

 aaa tac cac atc ctg aag acc cac gca gag ccc cca gca gcc ctg ctg     3769
 Lys Tyr His Ile Leu Lys Thr His Ala Glu Pro Pro Ala Ala Leu Leu
         960                 965                 970

 cag gtg ctt gcc tgg tcc cga agg ctg tgt cca gcc ctg ctg cag gtg     3817
 Gln Val Leu Ala Trp Ser Arg Arg Leu Cys Pro Ala Leu Leu Gln Val
     975                 980                 985

 ctt gcc tgg tcc cga agg ctg tgt cca gcc ccc tgc agg tgc ttg cct     3865
 Leu Ala Trp Ser Arg Arg Leu Cys Pro Ala Pro Cys Arg Cys Leu Pro
 990                 995                1000                1005

 ggt ccc gaa ggc tgt gtc cag ccc cct gct gca ggt gct tgc ctg gtc     3913
 Gly Pro Glu Gly Cys Val Gln Pro Pro Ala Ala Gly Ala Cys Leu Val
                1010                1015                1020

 ctg aag gct gtg tcc agc ccc ctg ctg cag gct gtg tcc agc cct gcg     3961
 Leu Lys Ala Val Ser Ser Pro Leu Leu Gln Ala Val Ser Ser Pro Ala
            1025                1030                1035

 gca ggt gcc tgc ctg gtc ctg aag gct gtg tcc agc cct gcg gca ggt     4009
 Ala Gly Ala Cys Leu Val Leu Lys Ala Val Ser Ser Pro Ala Ala Gly
        1040                1045                1050

 gcc tgc ctg gtc ctg aag gct gtg tcc agc cct gcg gca ggt gcc tgc     4057
 Ala Cys Leu Val Leu Lys Ala Val Ser Ser Pro Ala Ala Gly Ala Cys
    1055                1060                1065

 ctg gtc ctg aag gct gtg tcc agc cct gcg gca ggt gcc tgc ctg gtc     4105
 Leu Val Leu Lys Ala Val Ser Ser Pro Ala Ala Gly Ala Cys Leu Val
1070                1075                1080                1085

 ctg aag gct gtg tcc agc ccc ctg ctg cag aac tgg ttc cga aca tca     4153
 Leu Lys Ala Val Ser Ser Pro Leu Leu Gln Asn Trp Phe Arg Thr Ser
                1090                1095                1100

 gca gac cca cct ccc aaa cac agg agc cag gac tca ttg gtg ccc aag     4201
 Ala Asp Pro Pro Pro Lys His Arg Ser Gln Asp Ser Leu Val Pro Lys
            1105                1110                1115

 aag gaa aag aag aaa aat ctg gca ggt gga aag aag cgg ggc cga aag     4249
 Lys Glu Lys Lys Lys Asn Leu Ala Gly Gly Lys Lys Arg Gly Arg Lys
        1120                1125                1130

 ccc aag gag cgg acc cca gag gag cct gtg gcc aag ctg ccc ccg cgc     4297
 Pro Lys Glu Arg Thr Pro Glu Glu Pro Val Ala Lys Leu Pro Pro Arg
    1135                1140                1145

 cgg gac gac tgg cct cca gga tgc aga gac aag ggg gcc cgg ggc tcc     4345
 Arg Asp Asp Trp Pro Pro Gly Cys Arg Asp Lys Gly Ala Arg Gly Ser
1150                1155                1160                1165

 acc ggc cgg aag gtg gga gtc agc aag gcg cct gaa aag tga             4387
 Thr Gly Arg Lys Val Gly Val Ser Lys Ala Pro Glu Lys 
                1170                1175





      <210> 201
      <211> 4369
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (851)..(4369)

      <400> 201
 atgcagcgcc ggaattcccg ggtcgacgat ttcgtccggt tcctgaaagt tgcaagaatg     60

 ggggcggaag gtgttatgtc tcctaagtct tacaggcgtg ggaggacggg gaagtaggat    120

 gtggttttca ccgatactta gacctcctag acacatcccc aacccctgcc ctgggtgtgg    180

 agtgggtggc tgagtctgag gccgggaggg tctctcactc tagggtggat gggatgaggg    240

 ccctagcgtg ggaacctcac ctgccctgct gaaggcctgg gtgctaaggt gctgtaaaga    300

 caggggcagg cctgtgccca ccttctgtct ccccacaggc tctgttcact tgcagatacc    360

 atacagagcc ttcattcatt cattcattga caatgaatgt ggggtgcccc tctgtaacca    420

 gacctggatc aagacgcctg cctccccaga ctcagccact gcccacttca gcttctgccg    480

 gaccctcctg gagcacacgg tgtcagctga gagcatcccc tgccacttgc ctcggacacc    540

 tggcaccagc ctcacgtggc atgactcccg cagccagagg gcggccagca gcaggccaat    600

 caagctcctg cagcagcccg gcacagacac cccccagggc cggctgtact ctgaccacta    660

 tggcctgtac catacaagcc cctcgctggg tggcctgacc cggcccgtgg tcctgtggag    720

 tcagcaggac gtctgcaagt ggctcaagaa gcactgtccc cacaactacc tcgtctacgt    780

 ggaggccttc tcccagcatg ccatcaccgg ccgggcactg ctgcggctga atgcggagaa    840

 gctgcagcgg   atg ggg ctg gcc cag gag gcc cag agg cag gag gtg ctg     889
              Met Gly Leu Ala Gln Glu Ala Gln Arg Gln Glu Val Leu
                1               5                  10

 cag cag gtg ctc cgc ctg cag gtg cgt gag gag ggg cgg agc ctg cag      937
 Gln Gln Val Leu Arg Leu Gln Val Arg Glu Glu Gly Arg Ser Leu Gln
      15                  20                  25

 ctg ctc agc caa gaa aca cat ggg aca cgg cac atc ccc ggt gca cac      985
 Leu Leu Ser Gln Glu Thr His Gly Thr Arg His Ile Pro Gly Ala His
  30                  35                  40                  45

 aaa cac act gta ttc cac gac acc ctg gca tgt aga tgc tca cag aaa     1033
 Lys His Thr Val Phe His Asp Thr Leu Ala Cys Arg Cys Ser Gln Lys
                  50                  55                  60

 aca gcc gtc cct cac cag cac cct gac act gag aca tgc cgc agc ctg     1081
 Thr Ala Val Pro His Gln His Pro Asp Thr Glu Thr Cys Arg Ser Leu
              65                  70                  75

 gac aca tgg ata ctg aaa tcc aga cac atc gtc ccc agt cct gtg ctg     1129
 Asp Thr Trp Ile Leu Lys Ser Arg His Ile Val Pro Ser Pro Val Leu
          80                  85                  90

 tca gtg ccc cgc cac ctc cag acc act cag ccc aca ccg gac ccc agt     1177
 Ser Val Pro Arg His Leu Gln Thr Thr Gln Pro Thr Pro Asp Pro Ser
      95                 100                 105

 gcc ccc tgc ctg cag aag ccc aag ctg tgg ggc aga gaa ggc cct ggc     1225
 Ala Pro Cys Leu Gln Lys Pro Lys Leu Trp Gly Arg Glu Gly Pro Gly
 110                 115                 120                 125

 act ggt tca gaa cca ctg ccc cca gag ctg gga aag ggt gac cca atg     1273
 Thr Gly Ser Glu Pro Leu Pro Pro Glu Leu Gly Lys Gly Asp Pro Met
                 130                 135                 140

 gag tgc atc acc ttc ggc atc atc ttc gca gct gtg ggg cta cgc aca     1321
 Glu Cys Ile Thr Phe Gly Ile Ile Phe Ala Ala Val Gly Leu Arg Thr
             145                 150                 155

 ctg tgg agc tgc gta cac tgt aga gct gcg tgt tgg gaa ggg ggt ctg     1369
 Leu Trp Ser Cys Val His Cys Arg Ala Ala Cys Trp Glu Gly Gly Leu
         160                 165                 170

 gaa gtt gag atg acg gat cct ttc tgc gtt gga ggc cgt cgg ctc ccg     1417
 Glu Val Glu Met Thr Asp Pro Phe Cys Val Gly Gly Arg Arg Leu Pro
     175                 180                 185

 ggg tcc agc aag agt ggt ccc ggg aag gat ggc agc cga aag gag gtc     1465
 Gly Ser Ser Lys Ser Gly Pro Gly Lys Asp Gly Ser Arg Lys Glu Val
 190                 195                 200                 205

 cga ctt cca atg ctg cat gac cca ccg aag atg ggg atg ccg gtg gtc     1513
 Arg Leu Pro Met Leu His Asp Pro Pro Lys Met Gly Met Pro Val Val
                 210                 215                 220

 cgt ggt gga cag aca gtg ccc ggc cag gcc cct ctc tgc ttt gac ccg     1561
 Arg Gly Gly Gln Thr Val Pro Gly Gln Ala Pro Leu Cys Phe Asp Pro
             225                 230                 235

 gga agt cca gcc agt gac aag aca gaa ggg aag aaa aag ggg cgg cca     1609
 Gly Ser Pro Ala Ser Asp Lys Thr Glu Gly Lys Lys Lys Gly Arg Pro
         240                 245                 250

 aaa gcc gag aac cag gcc ctc cga gac att cct ctc tcc ctg atg aac     1657
 Lys Ala Glu Asn Gln Ala Leu Arg Asp Ile Pro Leu Ser Leu Met Asn
     255                 260                 265

 gac tgg aag gat gag ttc aag gca cac tcg agg gtg aag tgt cca aac     1705
 Asp Trp Lys Asp Glu Phe Lys Ala His Ser Arg Val Lys Cys Pro Asn
 270                 275                 280                 285

 tca ggg tgc tgg ctg gag ttc ccc agc atc tac ggg ctc aag tac cat     1753
 Ser Gly Cys Trp Leu Glu Phe Pro Ser Ile Tyr Gly Leu Lys Tyr His
                 290                 295                 300

 tac cag cgg tgc caa ggg ggt gcc atc tca gat cgc ctg gcc ttc ccc     1801
 Tyr Gln Arg Cys Gln Gly Gly Ala Ile Ser Asp Arg Leu Ala Phe Pro
             305                 310                 315

 tgc ccc ttc tgc gag gcc gca ttc acc tct aag acc cag ctg gag aaa     1849
 Cys Pro Phe Cys Glu Ala Ala Phe Thr Ser Lys Thr Gln Leu Glu Lys
         320                 325                 330

 cac cgg atc tgg aac cac atg gac cga ccc ctg cct gcc tcc aag cct     1897
 His Arg Ile Trp Asn His Met Asp Arg Pro Leu Pro Ala Ser Lys Pro
     335                 340                 345

 ggg ccc atc agc agg ccg gtc acc atc agc cgg cct gtt ggg gtc agc     1945
 Gly Pro Ile Ser Arg Pro Val Thr Ile Ser Arg Pro Val Gly Val Ser
 350                 355                 360                 365

 aag ccc atc gga gtg agc aaa cct gtc act att ggc aaa cct gtg ggt     1993
 Lys Pro Ile Gly Val Ser Lys Pro Val Thr Ile Gly Lys Pro Val Gly
                 370                 375                 380

 gtc agc aaa ccc att ggc atc agc aag cca gtc tcg gtc ggc aga ccc     2041
 Val Ser Lys Pro Ile Gly Ile Ser Lys Pro Val Ser Val Gly Arg Pro
             385                 390                 395

 atg cca gtc acc aag gcc atc ccg gtc act agg ccc gtg cca gtc acc     2089
 Met Pro Val Thr Lys Ala Ile Pro Val Thr Arg Pro Val Pro Val Thr
         400                 405                 410

 aaa cct gtc aca gtc agc agg ccc atg ccc gtc acc aag gcc atg ccg     2137
 Lys Pro Val Thr Val Ser Arg Pro Met Pro Val Thr Lys Ala Met Pro
     415                 420                 425

 gtc acc aaa ccc atc aca gtc acc aag tct gtg ccg gtc acc aaa ccc     2185
 Val Thr Lys Pro Ile Thr Val Thr Lys Ser Val Pro Val Thr Lys Pro
 430                 435                 440                 445

 gta cct gtc acc aaa ccc att acg gta aca aag ctt gtg aca gtt acg     2233
 Val Pro Val Thr Lys Pro Ile Thr Val Thr Lys Leu Val Thr Val Thr
                 450                 455                 460

 aaa ccc gtg ccg gtc acc aag cca gtg aca gtc agc agg ccc att gtg     2281
 Lys Pro Val Pro Val Thr Lys Pro Val Thr Val Ser Arg Pro Ile Val
             465                 470                 475

 gtc agc aag ccg gtg aca gtc agc agg ccc att gct atc agc aga cac     2329
 Val Ser Lys Pro Val Thr Val Ser Arg Pro Ile Ala Ile Ser Arg His
         480                 485                 490

 aca ccg ccc tgc aaa atg gtg ctg ctg acc agg tcg gag aac aaa gca     2377
 Thr Pro Pro Cys Lys Met Val Leu Leu Thr Arg Ser Glu Asn Lys Ala
     495                 500                 505

 cct cgt gcc aca ggg agg aac agt ggt aag aaa agg gct gcg gac agc     2425
 Pro Arg Ala Thr Gly Arg Asn Ser Gly Lys Lys Arg Ala Ala Asp Ser
 510                 515                 520                 525

 ctg gac acc tgc cca att cca ccc aag cag gcc agg cca gag aat ggg     2473
 Leu Asp Thr Cys Pro Ile Pro Pro Lys Gln Ala Arg Pro Glu Asn Gly
                 530                 535                 540

 gag tac ggc ccc tcc tcc atg ggc cag agc tcg gcc ttc cag ctg agt     2521
 Glu Tyr Gly Pro Ser Ser Met Gly Gln Ser Ser Ala Phe Gln Leu Ser
             545                 550                 555

 gca gac acc agc agt ggc tcc ttg tcg cca ggc agc agg ccg tca ggg     2569
 Ala Asp Thr Ser Ser Gly Ser Leu Ser Pro Gly Ser Arg Pro Ser Gly
         560                 565                 570

 ggc atg gag gca ctg aag gct gca ggc cct gcg tcc ccg cct gag gag     2617
 Gly Met Glu Ala Leu Lys Ala Ala Gly Pro Ala Ser Pro Pro Glu Glu
     575                 580                 585

 gac ccg gag cgc aca aag cac agc ctg gtc aaa gct gag gac aag gcc     2665
 Asp Pro Glu Arg Thr Lys His Ser Leu Val Lys Ala Glu Asp Lys Ala
 590                 595                 600                 605

 cga gtt cac cgc tcc aag aag cag gag ggg cca ggc cct gag gac gcc     2713
 Arg Val His Arg Ser Lys Lys Gln Glu Gly Pro Gly Pro Glu Asp Ala
                 610                 615                 620

 cgg aag aag gtg cca gct gcc ccc atc act gtc agc aag gag gca ccg     2761
 Arg Lys Lys Val Pro Ala Ala Pro Ile Thr Val Ser Lys Glu Ala Pro
             625                 630                 635

 gcc cct gtg gcc cac cca gct cca ggt ggc cct gaa gag cag tgg cag     2809
 Ala Pro Val Ala His Pro Ala Pro Gly Gly Pro Glu Glu Gln Trp Gln
         640                 645                 650

 agg gcc atc cat gag cgc ggg gaa gcc gtc tgc ccc acc tgc aac gtg     2857
 Arg Ala Ile His Glu Arg Gly Glu Ala Val Cys Pro Thr Cys Asn Val
     655                 660                 665

 gtc acc cgg aag act ctc gtg ggg ctt aag aag cac atg gag gtg tgt     2905
 Val Thr Arg Lys Thr Leu Val Gly Leu Lys Lys His Met Glu Val Cys
 670                 675                 680                 685

 cag aag ctt cag gat gca ctc aag tgc cag cac tgc cgg aag cag ttc     2953
 Gln Lys Leu Gln Asp Ala Leu Lys Cys Gln His Cys Arg Lys Gln Phe
                 690                 695                 700

 aag tcc aaa gcc ggc ctc aac tac cac act atg gcc gag cac agt gcc     3001
 Lys Ser Lys Ala Gly Leu Asn Tyr His Thr Met Ala Glu His Ser Ala
             705                 710                 715

 aag ccc tct gac gcc gag gcc tcc gaa ggg ggc gag cag gag gag cgc     3049
 Lys Pro Ser Asp Ala Glu Ala Ser Glu Gly Gly Glu Gln Glu Glu Arg
         720                 725                 730

 gag agg ctg cgc aag gtg ctg aag cag atg gga cgg ctg cgc tgc ccc     3097
 Glu Arg Leu Arg Lys Val Leu Lys Gln Met Gly Arg Leu Arg Cys Pro
     735                 740                 745

 cag gag ggt tgc ggg gct gcc ttc tcc agc ctc atg ggc tac cag tac     3145
 Gln Glu Gly Cys Gly Ala Ala Phe Ser Ser Leu Met Gly Tyr Gln Tyr
 750                 755                 760                 765

 cac cag cgg cgc tgc ggg aag ccg ccc tgc gag gtg gac agc ccc tcc     3193
 His Gln Arg Arg Cys Gly Lys Pro Pro Cys Glu Val Asp Ser Pro Ser
                 770                 775                 780

 ttc ccc tgc acc cac tgt ggc aag acg tac cga tcc aag gct ggc cac     3241
 Phe Pro Cys Thr His Cys Gly Lys Thr Tyr Arg Ser Lys Ala Gly His
             785                 790                 795

 gac tac cac gtg cgc tcg gag cac acg gcc ccc ccc cct gag gag ccc     3289
 Asp Tyr His Val Arg Ser Glu His Thr Ala Pro Pro Pro Glu Glu Pro
         800                 805                 810

 aca gac aag tcc cct gag gct gag gac ccg ctg ggt gtg gag cgg acc     3337
 Thr Asp Lys Ser Pro Glu Ala Glu Asp Pro Leu Gly Val Glu Arg Thr
     815                 820                 825

 cca agc ggg cgt gtc cgc cgc acg tcg gcc cag gtg gcg gtg ttc cac     3385
 Pro Ser Gly Arg Val Arg Arg Thr Ser Ala Gln Val Ala Val Phe His
 830                 835                 840                 845

 ctg cag gag ata gcg gag gac gag ctg gcc cgc gac tgg acc aag cgg     3433
 Leu Gln Glu Ile Ala Glu Asp Glu Leu Ala Arg Asp Trp Thr Lys Arg
                 850                 855                 860

 cgc atg aag gat gac ctt gtg ccc gag acc gca cgg ctc aac tac act     3481
 Arg Met Lys Asp Asp Leu Val Pro Glu Thr Ala Arg Leu Asn Tyr Thr
             865                 870                 875

 cga cca ggg ctc ccc acg ctg aac ccc cag ctg cta gag gca tgg aag     3529
 Arg Pro Gly Leu Pro Thr Leu Asn Pro Gln Leu Leu Glu Ala Trp Lys
         880                 885                 890

 aat gaa gtg aag gag aaa ggc cac gtc aac tgt ccc aac gac tgc tgt     3577
 Asn Glu Val Lys Glu Lys Gly His Val Asn Cys Pro Asn Asp Cys Cys
     895                 900                 905

 gaa gcc atc tac tcc agc gtg tcc gga ctc aag gct cat ctc gcc agc     3625
 Glu Ala Ile Tyr Ser Ser Val Ser Gly Leu Lys Ala His Leu Ala Ser
 910                 915                 920                 925

 tgc agt aag ggg gcc cac ctg gca ggg aag tac cgc tgt ctg ctg tgt     3673
 Cys Ser Lys Gly Ala His Leu Ala Gly Lys Tyr Arg Cys Leu Leu Cys
                 930                 935                 940

 ccg aag gag ttc agt tct gag agt ggc gtc aaa tac cac atc ctg aag     3721
 Pro Lys Glu Phe Ser Ser Glu Ser Gly Val Lys Tyr His Ile Leu Lys
             945                 950                 955

 acc cac gca gag ccc cca gca gcc ctg ctg cag gtg ctt gcc tgg tcc     3769
 Thr His Ala Glu Pro Pro Ala Ala Leu Leu Gln Val Leu Ala Trp Ser
         960                 965                 970

 cga agg ctg tgt cca gcc ctg ctg cag gtg ctt gcc tgg tcc cga agg     3817
 Arg Arg Leu Cys Pro Ala Leu Leu Gln Val Leu Ala Trp Ser Arg Arg
     975                 980                 985

 ctg tgt cca gcc ccc tgc agg tgc ttg cct ggt ccc gaa ggc tgt gtc     3865
 Leu Cys Pro Ala Pro Cys Arg Cys Leu Pro Gly Pro Glu Gly Cys Val
 990                 995                1000                1005

 cag ccc cct gct gca ggt gct tgc ctg gtc ctg aag gct gtg tcc agc     3913
 Gln Pro Pro Ala Ala Gly Ala Cys Leu Val Leu Lys Ala Val Ser Ser
                1010                1015                1020

 ccc ctg ctg cag gct gtg tcc agc cct gcg gca ggt gcc tgc ctg gtc     3961
 Pro Leu Leu Gln Ala Val Ser Ser Pro Ala Ala Gly Ala Cys Leu Val
            1025                1030                1035

 ctg aag gct gtg tcc agc cct gcg gca ggt gcc tgc ctg gtc ctg aag     4009
 Leu Lys Ala Val Ser Ser Pro Ala Ala Gly Ala Cys Leu Val Leu Lys
        1040                1045                1050

 gct gtg tcc agc cct gcg gca ggt gcc tgc ctg gtc ctg aag gct gtg     4057
 Ala Val Ser Ser Pro Ala Ala Gly Ala Cys Leu Val Leu Lys Ala Val
    1055                1060                1065

 tcc agc cct gcg gca ggt gcc tgc ctg gtc ctg aag gct gtg tcc agc     4105
 Ser Ser Pro Ala Ala Gly Ala Cys Leu Val Leu Lys Ala Val Ser Ser
1070                1075                1080                1085

 ccc ctg ctg cag aac tgg ttc cga aca tca gca gac cca cct ccc aaa     4153
 Pro Leu Leu Gln Asn Trp Phe Arg Thr Ser Ala Asp Pro Pro Pro Lys
                1090                1095                1100

 cac agg agc cag gac tca ttg gtg ccc aag aag gaa aag aag aaa aat     4201
 His Arg Ser Gln Asp Ser Leu Val Pro Lys Lys Glu Lys Lys Lys Asn
            1105                1110                1115

 ctg gca ggt gga aag aag cgg ggc cga aag ccc aag gag cgg acc cca     4249
 Leu Ala Gly Gly Lys Lys Arg Gly Arg Lys Pro Lys Glu Arg Thr Pro
        1120                1125                1130

 gag gag cct gtg gcc aag ctg ccc ccg cgc cgg gac gac tgg cct cca     4297
 Glu Glu Pro Val Ala Lys Leu Pro Pro Arg Arg Asp Asp Trp Pro Pro
    1135                1140                1145

 gga tgc aga gac aag ggg gcc cgg ggc tcc acc ggc cgg aag gtg gga     4345
 Gly Cys Arg Asp Lys Gly Ala Arg Gly Ser Thr Gly Arg Lys Val Gly
1150                1155                1160                1165

 gtc agc aag gcg cct gaa aag tga                                     4369
 Val Ser Lys Ala Pro Glu Lys 
                1170





      <210> 202
      <211> 3205
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (592)..(3045)

      <400> 202
 ggtggagggt ccggggagga gcaactctat gctgactttc cagaactcga cctctcccag     60

 ctggatgcca gcgactttga ctcggccacc tgctttgggg agctgcagtg gtgcccagag    120

 aactcagaga ctgaacccaa ccagtacagc cccgatgact ccgagctctt ccagcctacc    180

 tttaagtatc agctgctcag agaaggcatc tgggaccacc ctcaagagcc tattgacagt    240

 gagaatgagg ccctcctggc agagctcacc aagaccctgg atgacatccc tgaagatgac    300

 gtgggtctgg ctgccttccc agccctggat ggtggagacg ctctatcatg cacctcagct    360

 tcgcctgccc cctcatctgc accccccagc cctgccccgg agaagccctc ggccccagcc    420

 cctgaggtgg acgagctctc actgctgcag aagctcctcc tggccacatc ctacccaaca    480

 tcaagctctg acacccagaa ggaagggacc gcctggcgcc aggcaggcct cagatctaaa    540

 agtcaacggc cttgtgttaa ggcggacagc acccaagaca agaaggctcc c atg atg     597
                                                          Met Met
                                                            1

 cag tct cag agc cga agt tgt aca gaa cta cat aag cac ctc acc tcg      645
 Gln Ser Gln Ser Arg Ser Cys Thr Glu Leu His Lys His Leu Thr Ser
           5                  10                  15

 gca cag tgc tgc ctg cag gat cgg ggt ctg cag cca cca tgc ctc cag      693
 Ala Gln Cys Cys Leu Gln Asp Arg Gly Leu Gln Pro Pro Cys Leu Gln
      20                  25                  30

 agt ccc cgg ctc cct gcc aag gag gac aag gag ccg ggt gag gac tgc      741
 Ser Pro Arg Leu Pro Ala Lys Glu Asp Lys Glu Pro Gly Glu Asp Cys
  35                  40                  45                  50

 ccg agc ccc cag cca gct cca gcc tct ccc cgg gac tcc cta gct ctg      789
 Pro Ser Pro Gln Pro Ala Pro Ala Ser Pro Arg Asp Ser Leu Ala Leu
                  55                  60                  65

 ggc agg gca gac ccc ggt gcc ccg gtt tcc cag gaa gac atg cag gcg      837
 Gly Arg Ala Asp Pro Gly Ala Pro Val Ser Gln Glu Asp Met Gln Ala
              70                  75                  80

 atg gtg caa ctc ata cgc tac atg cac acc tac tgc ctc ccc cag agg      885
 Met Val Gln Leu Ile Arg Tyr Met His Thr Tyr Cys Leu Pro Gln Arg
          85                  90                  95

 aag ctg ccc cca cag acc cct gag cca ctc ccc aag gcc tgc agc aac      933
 Lys Leu Pro Pro Gln Thr Pro Glu Pro Leu Pro Lys Ala Cys Ser Asn
     100                 105                 110

 ccc tcc cag cag gtc aga tcc cgg ccc tgg tcc cgg cac cac tcc aaa      981
 Pro Ser Gln Gln Val Arg Ser Arg Pro Trp Ser Arg His His Ser Lys
 115                 120                 125                 130

 gcc tcc tgg gct gag ttc tcc att ctg agg gaa ctt ctg gct caa gac     1029
 Ala Ser Trp Ala Glu Phe Ser Ile Leu Arg Glu Leu Leu Ala Gln Asp
                 135                 140                 145

 gtg ctc tgt gat gtc agc aaa ccc tac cgt ctg gcc acg cct gtt tat     1077
 Val Leu Cys Asp Val Ser Lys Pro Tyr Arg Leu Ala Thr Pro Val Tyr
             150                 155                 160

 gcc tcc ctc aca cct cgg tca agg ccc agg ccc ccc aaa gac agt cag     1125
 Ala Ser Leu Thr Pro Arg Ser Arg Pro Arg Pro Pro Lys Asp Ser Gln
         165                 170                 175

 gcc tcc cct ggt cgc ccg tcc tcg gtg gag gag gta agg atc gca gct     1173
 Ala Ser Pro Gly Arg Pro Ser Ser Val Glu Glu Val Arg Ile Ala Ala
     180                 185                 190

 tca ccc aag agc acc ggg ccc aga cca agc ctg cgc cca ctg cgg ctg     1221
 Ser Pro Lys Ser Thr Gly Pro Arg Pro Ser Leu Arg Pro Leu Arg Leu
 195                 200                 205                 210

 gag gtg aaa agg gag gtc cgc cgg cct gcc aga ctg cag cag cag gag     1269
 Glu Val Lys Arg Glu Val Arg Arg Pro Ala Arg Leu Gln Gln Gln Glu
                 215                 220                 225

 gag gaa gac gag gaa gaa gag gag gag gaa gag gaa gaa gaa aaa gag     1317
 Glu Glu Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Lys Glu
             230                 235                 240

 gag gag gag gag tgg ggc agg aaa agg cca ggc cga ggc ctg cca tgg     1365
 Glu Glu Glu Glu Trp Gly Arg Lys Arg Pro Gly Arg Gly Leu Pro Trp
         245                 250                 255

 acg aag ctg ggg agg aag ctg gag agc tct gtg tgc ccc gtg cgg cgt     1413
 Thr Lys Leu Gly Arg Lys Leu Glu Ser Ser Val Cys Pro Val Arg Arg
     260                 265                 270

 tct cgg aga ctg aac cct gag ctg ggc ccc tgg ctg aca ttt gca gat     1461
 Ser Arg Arg Leu Asn Pro Glu Leu Gly Pro Trp Leu Thr Phe Ala Asp
 275                 280                 285                 290

 gag ccg ctg gtc ccc tcg gag ccc caa ggt gct ctg ccc tca ctg tgc     1509
 Glu Pro Leu Val Pro Ser Glu Pro Gln Gly Ala Leu Pro Ser Leu Cys
                 295                 300                 305

 ctg gct ccc aag gcc tac gac gta gag cgg gag ctg ggc agc ccc acg     1557
 Leu Ala Pro Lys Ala Tyr Asp Val Glu Arg Glu Leu Gly Ser Pro Thr
             310                 315                 320

 gac gag gac agt ggc caa gac cag cag ctc cta cgg gga ccc cag atc     1605
 Asp Glu Asp Ser Gly Gln Asp Gln Gln Leu Leu Arg Gly Pro Gln Ile
         325                 330                 335

 cct gcc ctg gag agc ccc tgt gag agt ggc gac cca act ttt ggc aag     1653
 Pro Ala Leu Glu Ser Pro Cys Glu Ser Gly Asp Pro Thr Phe Gly Lys
     340                 345                 350

 aag agc ttt gag cag acc ttg aca gtg gag ctc tgt ggc aca gca ggt     1701
 Lys Ser Phe Glu Gln Thr Leu Thr Val Glu Leu Cys Gly Thr Ala Gly
 355                 360                 365                 370

 gag cca ggg ggc ttc cac tgg cag gtg cct tca gga aaa cac ccg tgc     1749
 Glu Pro Gly Gly Phe His Trp Gln Val Pro Ser Gly Lys His Pro Cys
                 375                 380                 385

 atc tct gag ttt ttc atc atg cat ggg caa gga ctc acc cca ccc acc     1797
 Ile Ser Glu Phe Phe Ile Met His Gly Gln Gly Leu Thr Pro Pro Thr
             390                 395                 400

 aca cca ccg tac aag ccc aca gag gag gat ccc ttc aaa cca gac atc     1845
 Thr Pro Pro Tyr Lys Pro Thr Glu Glu Asp Pro Phe Lys Pro Asp Ile
         405                 410                 415

 aag cat agt cta ggc aaa gaa ata gct ctc agc ctc ccc tcc cct gag     1893
 Lys His Ser Leu Gly Lys Glu Ile Ala Leu Ser Leu Pro Ser Pro Glu
     420                 425                 430

 ggc ctc tca ctc aag gcc acc cca ggg gct gcc cac aag ctg cca aag     1941
 Gly Leu Ser Leu Lys Ala Thr Pro Gly Ala Ala His Lys Leu Pro Lys
 435                 440                 445                 450

 aag cac cca gag cga agt gag ctc ctg tcc cac ctg cga cat gcc aca     1989
 Lys His Pro Glu Arg Ser Glu Leu Leu Ser His Leu Arg His Ala Thr
                 455                 460                 465

 gcc cag cca gcc tcc cag gct ggc cag aag cgt ccc ttc tcc tgt tcc     2037
 Ala Gln Pro Ala Ser Gln Ala Gly Gln Lys Arg Pro Phe Ser Cys Ser
             470                 475                 480

 ttt gga gac cat gac tac tgc cag gtg ctc cga cca gaa ggc gtc ctg     2085
 Phe Gly Asp His Asp Tyr Cys Gln Val Leu Arg Pro Glu Gly Val Leu
         485                 490                 495

 caa agg aag gtg ctg agg tcc tgg gag ccg tct ggg gtt cac ctt gag     2133
 Gln Arg Lys Val Leu Arg Ser Trp Glu Pro Ser Gly Val His Leu Glu
     500                 505                 510

 gac tgg ccc cag cag ggt gcc cct tgg gct gag gca cag gcc cct ggc     2181
 Asp Trp Pro Gln Gln Gly Ala Pro Trp Ala Glu Ala Gln Ala Pro Gly
 515                 520                 525                 530

 agg gag gaa gac aga agc tgt gat gct ggc gcc cca ccc aag gac agc     2229
 Arg Glu Glu Asp Arg Ser Cys Asp Ala Gly Ala Pro Pro Lys Asp Ser
                 535                 540                 545

 acg ctg ctg aga gac cat gag atc cgt gcc agc ctc acc aaa cac ttt     2277
 Thr Leu Leu Arg Asp His Glu Ile Arg Ala Ser Leu Thr Lys His Phe
             550                 555                 560

 ggg ctg ctg gag acc gcc ctg gag gag gaa gac ctg gcc tcc tgc aag     2325
 Gly Leu Leu Glu Thr Ala Leu Glu Glu Glu Asp Leu Ala Ser Cys Lys
         565                 570                 575

 agc cct gag tat gac act gtc ttt gaa gac agc agc agc agc agc ggc     2373
 Ser Pro Glu Tyr Asp Thr Val Phe Glu Asp Ser Ser Ser Ser Ser Gly
     580                 585                 590

 gag agc agc ttc ctc cca gag gag gaa gag gaa gaa ggg gag gag gag     2421
 Glu Ser Ser Phe Leu Pro Glu Glu Glu Glu Glu Glu Gly Glu Glu Glu
 595                 600                 605                 610

 gag gag gac gat gaa gaa gag gac tca ggg gtc agc ccc act tgc tct     2469
 Glu Glu Asp Asp Glu Glu Glu Asp Ser Gly Val Ser Pro Thr Cys Ser
                 615                 620                 625

 gac cac tgc ccc tac cag agc cca cca agc aag gcc aac cgg cag ctc     2517
 Asp His Cys Pro Tyr Gln Ser Pro Pro Ser Lys Ala Asn Arg Gln Leu
             630                 635                 640

 tgt tcc cgc agc cgc tca agc tct ggc tct tca ccc tgc cac tcc tgg     2565
 Cys Ser Arg Ser Arg Ser Ser Ser Gly Ser Ser Pro Cys His Ser Trp
         645                 650                 655

 tca cca gcc act cga agg aac ttc aga tgt gag agc aga ggg ccg tgt     2613
 Ser Pro Ala Thr Arg Arg Asn Phe Arg Cys Glu Ser Arg Gly Pro Cys
     660                 665                 670

 tca gac aga acg cca agc atc cgg cac gcc agg aag cgg cgg gaa aag     2661
 Ser Asp Arg Thr Pro Ser Ile Arg His Ala Arg Lys Arg Arg Glu Lys
 675                 680                 685                 690

 gcc att ggg gaa ggc cgc gtg gtg tac att caa aat ctc tcc agc gac     2709
 Ala Ile Gly Glu Gly Arg Val Val Tyr Ile Gln Asn Leu Ser Ser Asp
                 695                 700                 705

 atg agc tcc cga gag ctg aag agg cgc ttt gaa gtg ttt ggt gag att     2757
 Met Ser Ser Arg Glu Leu Lys Arg Arg Phe Glu Val Phe Gly Glu Ile
             710                 715                 720

 gag gag tgc gag gtg ctg aca aga aat agg aga ggc gag aag tac ggc     2805
 Glu Glu Cys Glu Val Leu Thr Arg Asn Arg Arg Gly Glu Lys Tyr Gly
         725                 730                 735

 ttc atc acc tac cgg tgt tct gag cac gcg gcc ctc tct ttg aca aag     2853
 Phe Ile Thr Tyr Arg Cys Ser Glu His Ala Ala Leu Ser Leu Thr Lys
     740                 745                 750

 ggc gct gcc ctg agg aag cgc aac gag ccc tcc ttc cag ctg agc tac     2901
 Gly Ala Ala Leu Arg Lys Arg Asn Glu Pro Ser Phe Gln Leu Ser Tyr
 755                 760                 765                 770

 gga ggg ctc cgg cac ttc tgc tgg ccc aga tac act gac tac gat tcc     2949
 Gly Gly Leu Arg His Phe Cys Trp Pro Arg Tyr Thr Asp Tyr Asp Ser
                 775                 780                 785

 aat tca gaa gag gcc ctt cct gcg tca ggg aaa agc aag tat gaa gcc     2997
 Asn Ser Glu Glu Ala Leu Pro Ala Ser Gly Lys Ser Lys Tyr Glu Ala
             790                 795                 800

 atg gat ttt gac agc tta ctg aaa gag gcc cag cag agc ctg cat tga     3045
 Met Asp Phe Asp Ser Leu Leu Lys Glu Ala Gln Gln Ser Leu His 
         805                 810                 815

 taacagcctt aaccctcgag gaatacctca atacctcaga caaggccctt ccaatatgtt   3105

 tacgttttca aagaaatcaa gtatatgagg agagcgagcg agcgtgagag aacacccgtg   3165

 agagagactt gaaactgctg tcctttaaaa aaaaaaaaaa                         3205




      <210> 203
      <211> 1192
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (90)..(527)

      <220>
      <221> misc_feature
      <222> (1)...(1192)
      <223> n = a,t,c or g

      <400> 203
 gcttggcacg aggcctcgca gccacgcccc cctgagcccc ctcgtctgct tcttgtttgg     60

 cagaaataga tgtggggcac agttcctag  atg atg gga atc tgc cca agc tgt     113
                                  Met Met Gly Ile Cys Pro Ser Cys
                                    1               5

 gtc ctc tgg gga atg aaa tct tgc tcc tcg tgc agc ttc ccc ttt ccc      161
 Val Leu Trp Gly Met Lys Ser Cys Ser Ser Cys Ser Phe Pro Phe Pro
      10                  15                  20

 ttg cgg ggt ggg ggc tgg ggg tgc caa ggc tcc acc ctt gga ggg ggt      209
 Leu Arg Gly Gly Gly Trp Gly Cys Gln Gly Ser Thr Leu Gly Gly Gly
  25                  30                  35                  40

 tgc tgg ggg tgc caa ggc tcc acc ctt tgc tcg ctg ggc aga ggg aag      257
 Cys Trp Gly Cys Gln Gly Ser Thr Leu Cys Ser Leu Gly Arg Gly Lys
                  45                  50                  55

 gaa gca cct ccc tgt atg ctc tgc agg ggc ccc tgc agg cca ctt tgc      305
 Glu Ala Pro Pro Cys Met Leu Cys Arg Gly Pro Cys Arg Pro Leu Cys
              60                  65                  70

 ctc aga gga agg agg aga ggt ccc ctg gga aaa tgc gca cac aca cac      353
 Leu Arg Gly Arg Arg Arg Gly Pro Leu Gly Lys Cys Ala His Thr His
          75                  80                  85

 aca cac acg cac aca cgc aca tgc aca cac gca cgc atg cac aca cac      401
 Thr His Thr His Thr Arg Thr Cys Thr His Ala Arg Met His Thr His
      90                  95                 100

 aca cac ata tgt gca ggg gtg cag cct aag tca ggg gag cca gga ctg      449
 Thr His Ile Cys Ala Gly Val Gln Pro Lys Ser Gly Glu Pro Gly Leu
 105                 110                 115                 120

 ggt gcg cag ctg ggc ctg ccc cat tct tgg agt ccc cag gga atg agc      497
 Gly Ala Gln Leu Gly Leu Pro His Ser Trp Ser Pro Gln Gly Met Ser
                 125                 130                 135

 ctc agg atc cac ttc gtc cct tgt ttc taa g ccaggctgca cggccgttcc      548
 Leu Arg Ile His Phe Val Pro Cys Phe 
             140                 145

 tgggtgtgaa agcattctgt cctgtctcca gtcagaggga accgccccca aactagaaag    608

 ctaatttccc ccgaaggttc atgaagccag aggcatgccc ttgggggttg gtcgggagaa    668

 gggtgagagg cagtgctgtg gaaggggcct ggcccctgct gcctgcgatt ctccccgggt    728

 atgtggcctt ctgcctcctt cagcctcagt ttcctcacct gtaacatgag aataatgatg    788

 cctgcctgcc caggccacct cctgggactg cagtggggac tctaagtgta aaactgtcat    848

 gaggatggtt tatgaagtcc cagggaccac acctgccact cagggaagag accgctgacc    908

 tcagccatca gccgtgtgca tcgtgagggg cagcgagctc aggacggaga gctctccctt    968

 ggttcggagt cagcacacct gcactcccac acgcccaccc agctgtgtgt cctccgccga   1028

 gggcgagcct ctctgtgact cttctgtaaa aatgcacccc atttttgccc acttcctgcc   1088

 acgagaccca tcctcttgcg atcccgccag gcatgtgtgt gtgaatgcat gtgcaaagtt   1148

 ttccatcaga agggtggttn tgggccctgc aagtcctaac cctt                    1192




      <210> 204
      <211> 2471
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (137)..(2005)

      <400> 204
 gtgccggccc tgaattcccg ggtcgacgat ttcgtgccag caggaagtgg gagaagaggc     60

 gacccaaggc gggctggcgg gctggcggca gtcgctactt gcctagtagc ctcagccgct    120

 gtgggctcct ggggag    atg gag ggg ccg ggg ctg ggc tcg cag tgc agg     169
                      Met Glu Gly Pro Gly Leu Gly Ser Gln Cys Arg
                        1               5                  10

 aat cac agc cat ggc ccc cac cct cca gga ttt ggt cga tat ggc atc      217
 Asn His Ser His Gly Pro His Pro Pro Gly Phe Gly Arg Tyr Gly Ile
              15                  20                  25

 tgt gca cat gaa aac aaa gaa ctt gcc aat gca aga gaa gct ctt cct      265
 Cys Ala His Glu Asn Lys Glu Leu Ala Asn Ala Arg Glu Ala Leu Pro
          30                  35                  40

 ctt ata gag gac tct agt aac tgt gac att gtc aaa gct act caa tac      313
 Leu Ile Glu Asp Ser Ser Asn Cys Asp Ile Val Lys Ala Thr Gln Tyr
      45                  50                  55

 gga att ttt gaa cga tgt aaa gag ttg gta gaa gca gga tat gat gtc      361
 Gly Ile Phe Glu Arg Cys Lys Glu Leu Val Glu Ala Gly Tyr Asp Val
  60                  65                  70                  75

 agg caa cca gat aaa gaa aat gtg tcg ctt ctt cat tgg gct gct att      409
 Arg Gln Pro Asp Lys Glu Asn Val Ser Leu Leu His Trp Ala Ala Ile
                  80                  85                  90

 aac aac aga ctg gat ctt gta agg ttt tat att tca aaa ggt gct gtt      457
 Asn Asn Arg Leu Asp Leu Val Arg Phe Tyr Ile Ser Lys Gly Ala Val
              95                 100                 105

 gta gat cag ttg ggt gga gat tta aat tca act cct ctt cac tgg gcc      505
 Val Asp Gln Leu Gly Gly Asp Leu Asn Ser Thr Pro Leu His Trp Ala
         110                 115                 120

 atc cga caa gga cat tta cct atg gtc ata tta tta ctc cag cat ggt      553
 Ile Arg Gln Gly His Leu Pro Met Val Ile Leu Leu Leu Gln His Gly
     125                 130                 135

 gca gac ccc act ctt att gat gga gag gga ttc agc agc atc cac ctg      601
 Ala Asp Pro Thr Leu Ile Asp Gly Glu Gly Phe Ser Ser Ile His Leu
 140                 145                 150                 155

 gca gta ttg ttt caa cac atg cct att ata gca tat ctc atc tca aag      649
 Ala Val Leu Phe Gln His Met Pro Ile Ile Ala Tyr Leu Ile Ser Lys
                 160                 165                 170

 gga cag agt gtg aat atg aca gat gta aat ggg cag aca cct ctc atg      697
 Gly Gln Ser Val Asn Met Thr Asp Val Asn Gly Gln Thr Pro Leu Met
             175                 180                 185

 tta tca gct cac aaa gta att ggg cca gaa cca act gga ttt ctt tta      745
 Leu Ser Ala His Lys Val Ile Gly Pro Glu Pro Thr Gly Phe Leu Leu
         190                 195                 200

 aag ttt aat cct tct ctc aat gtg gtt gat aaa ata cac caa aac act      793
 Lys Phe Asn Pro Ser Leu Asn Val Val Asp Lys Ile His Gln Asn Thr
     205                 210                 215

 cca ctt cac tgg gca gtt gca gca gga aat gtt aat gca gtt gat aag      841
 Pro Leu His Trp Ala Val Ala Ala Gly Asn Val Asn Ala Val Asp Lys
 220                 225                 230                 235

 ctt ttg gaa gct ggt tct agc ctg gat atc cag aat gtt aag gga gaa      889
 Leu Leu Glu Ala Gly Ser Ser Leu Asp Ile Gln Asn Val Lys Gly Glu
                 240                 245                 250

 aca cct ctt gat atg gct cta caa aac aaa aat cag ctc att att cat      937
 Thr Pro Leu Asp Met Ala Leu Gln Asn Lys Asn Gln Leu Ile Ile His
             255                 260                 265

 atg cta aaa aca gaa gcc aaa atg aga gcc aac caa aag ttc aga ctt      985
 Met Leu Lys Thr Glu Ala Lys Met Arg Ala Asn Gln Lys Phe Arg Leu
         270                 275                 280

 tgg agg tgg ctg cag aaa tgc gag ctc ttc ctg ctg ctg atg ctt tct     1033
 Trp Arg Trp Leu Gln Lys Cys Glu Leu Phe Leu Leu Leu Met Leu Ser
     285                 290                 295

 gtg att acc atg tgg gct att gga tac ata ttg gac ttc aat tca gat     1081
 Val Ile Thr Met Trp Ala Ile Gly Tyr Ile Leu Asp Phe Asn Ser Asp
 300                 305                 310                 315

 tct tgg ctt tta aaa gga tgt ctt cta gta aca ctg ttt ttt ctg aca     1129
 Ser Trp Leu Leu Lys Gly Cys Leu Leu Val Thr Leu Phe Phe Leu Thr
                 320                 325                 330

 tct ttg ttt cca agg ttc ttg gtt ggg tat aag aac ctt gta tac tta     1177
 Ser Leu Phe Pro Arg Phe Leu Val Gly Tyr Lys Asn Leu Val Tyr Leu
             335                 340                 345

 cca aca gcc ttt ctg cta agt tct gtt ttt tgg ata ttt atg act tgg     1225
 Pro Thr Ala Phe Leu Leu Ser Ser Val Phe Trp Ile Phe Met Thr Trp
         350                 355                 360

 ttc atc tta ttt ttt cct gat tta gca gga gcc cct ttc tat ttc agt     1273
 Phe Ile Leu Phe Phe Pro Asp Leu Ala Gly Ala Pro Phe Tyr Phe Ser
     365                 370                 375

 ttc att ttc agc ata gta gcc ttt cta tac ttt ttc tat aag act tgg     1321
 Phe Ile Phe Ser Ile Val Ala Phe Leu Tyr Phe Phe Tyr Lys Thr Trp
 380                 385                 390                 395

 gca act gat cca ggc ttc act aag gct tct gaa gaa gaa aag aaa gtg     1369
 Ala Thr Asp Pro Gly Phe Thr Lys Ala Ser Glu Glu Glu Lys Lys Val
                 400                 405                 410

 aat atc atc acc ctt gca gaa act ggc tct ctg gac ttc aga aca ttt     1417
 Asn Ile Ile Thr Leu Ala Glu Thr Gly Ser Leu Asp Phe Arg Thr Phe
             415                 420                 425

 tgt aca tca tgt ctt ata agg aag cca tta agg tca ctc cac tgc cat     1465
 Cys Thr Ser Cys Leu Ile Arg Lys Pro Leu Arg Ser Leu His Cys His
         430                 435                 440

 gta tgc aac tgc tgt gtg gct cga tat gat caa cac tgc ctg tgg act     1513
 Val Cys Asn Cys Cys Val Ala Arg Tyr Asp Gln His Cys Leu Trp Thr
     445                 450                 455

 gga cgg tgc ata ggt ttt ggc aac cat cac tat tac ata ttc ttc ttg     1561
 Gly Arg Cys Ile Gly Phe Gly Asn His His Tyr Tyr Ile Phe Phe Leu
 460                 465                 470                 475

 ttt ttc ctt tcc atg gta tgt ggc tgg att ata tat gga tct ttc atc     1609
 Phe Phe Leu Ser Met Val Cys Gly Trp Ile Ile Tyr Gly Ser Phe Ile
                 480                 485                 490

 tat ttg tcc agt cat tgt gcc aca aca ttc aaa gaa gat gga tta tgg     1657
 Tyr Leu Ser Ser His Cys Ala Thr Thr Phe Lys Glu Asp Gly Leu Trp
             495                 500                 505

 act tac ctc aat cag att gtg gcc tgt tcc cct tgg gtt tta tat atc     1705
 Thr Tyr Leu Asn Gln Ile Val Ala Cys Ser Pro Trp Val Leu Tyr Ile
         510                 515                 520

 ttg atg cta gca act ttc cat ttc tca tgg tca aca ttt tta tta tta     1753
 Leu Met Leu Ala Thr Phe His Phe Ser Trp Ser Thr Phe Leu Leu Leu
     525                 530                 535

 aat caa ctc ttt cag att gcc ttt ctg ggc ctg acc tcc cat gag aga     1801
 Asn Gln Leu Phe Gln Ile Ala Phe Leu Gly Leu Thr Ser His Glu Arg
 540                 545                 550                 555

 atc agc ctg cag aag cag agc aag cat atg aaa cag acg ttg tcc ctc     1849
 Ile Ser Leu Gln Lys Gln Ser Lys His Met Lys Gln Thr Leu Ser Leu
                 560                 565                 570

 agg aag aca cca tac aat ctt gga ttc atg cag aac ctg gca gat ttc     1897
 Arg Lys Thr Pro Tyr Asn Leu Gly Phe Met Gln Asn Leu Ala Asp Phe
             575                 580                 585

 ttt cag tgt ggc tgc ttt ggc ttg gtg aag ccc tgt gtg gta gat tgg     1945
 Phe Gln Cys Gly Cys Phe Gly Leu Val Lys Pro Cys Val Val Asp Trp
         590                 595                 600

 aca tca cag tac acc atg gtc ttt cac cca gcc agg gag aag gtt ctt     1993
 Thr Ser Gln Tyr Thr Met Val Phe His Pro Ala Arg Glu Lys Val Leu
     605                 610                 615

 cgc tca gta tga aga aaagcaaccc aaaactctca atctgatttg tttttgttta     2048
 Arg Ser Val 
 620

 tgtcgatgcc ctgtagtttg aaagtgaagt aaagatttag aattcaccta agtccaaagg   2108

 aaaacacgtg gtttttaaag ccattaggta aaaaaagttc tcaataaagg cattacaatt   2168

 ttttaggttt agaaagatgg acttttctga taaatcttgg cagacatcta aaaaaaaaac   2228

 catatttttc acaagaaaat gcaagttact ttttttggaa ataatactca ctgattatgg   2288

 ataaaatgga atattttcag atactatatt ggctgtttca aaatagtact attctttaaa   2348

 cttgtaattt ttgctaagtt atttgtcttt gttgtatcta taaatatgta aaaaatattt   2408

 aaatagatgt acctgttttg ctttcacact taataaaaaa tttttttttg taaaaaaaaa   2468

 aaa                                                                 2471




      <210> 205
      <211> 1571
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (117)..(1091)

      <220>
      <221> misc_feature
      <222> (1)...(1571)
      <223> n = a,t,c or g

      <400> 205
 agtcgacgat ttcgtcccgc tccccgccgg gacgccccgc gccgagccgg aggccgcgtg     60

 gacccgaaag ccgctgggaa aagtttaccc aatgtccagc ctagccccta ggcacc        116                                                                 
 atg tcg gac agt gat cta ggt gag gac gaa ggc ctc ctc tcc ctg gcg      164
 Met Ser Asp Ser Asp Leu Gly Glu Asp Glu Gly Leu Leu Ser Leu Ala
   1               5                  10                  15

 ggc aaa agg aag cgc agg ggg aac ctg ccc aag gag tcg gtg aag atc      212
 Gly Lys Arg Lys Arg Arg Gly Asn Leu Pro Lys Glu Ser Val Lys Ile
              20                  25                  30

 ctc cgg gac tgg ctg tac ttg cac cgc tac aac gcc tac ccc tca gag      260
 Leu Arg Asp Trp Leu Tyr Leu His Arg Tyr Asn Ala Tyr Pro Ser Glu
          35                  40                  45

 cag gag aag ctg agc ctt tct gga cag acc aac ctg tca gtg ctg caa      308
 Gln Glu Lys Leu Ser Leu Ser Gly Gln Thr Asn Leu Ser Val Leu Gln
      50                  55                  60

 ata tgt aac tgg ttc atc aat gcc cgg cgg cgg ctt ctc cca gac atg      356
 Ile Cys Asn Trp Phe Ile Asn Ala Arg Arg Arg Leu Leu Pro Asp Met
  65                  70                  75                  80

 ctt cgg aag gat ggc aaa gac cct aat cag ttt acc att tcc cgc cgc      404
 Leu Arg Lys Asp Gly Lys Asp Pro Asn Gln Phe Thr Ile Ser Arg Arg
                  85                  90                  95

 ggg ggt aag gcc tca gat gtg gcc ctc ccc cgt ggc agc agc ccc tca      452
 Gly Gly Lys Ala Ser Asp Val Ala Leu Pro Arg Gly Ser Ser Pro Ser
             100                 105                 110

 gtg ctg gct gtg tct gtc cca gcc ccc acc aat gtg ctc tcc ctg tct      500
 Val Leu Ala Val Ser Val Pro Ala Pro Thr Asn Val Leu Ser Leu Ser
         115                 120                 125

 gtg tgc tcc atg ccg ctt cac tca ggc cag ggg gaa aag cca gca gcc      548
 Val Cys Ser Met Pro Leu His Ser Gly Gln Gly Glu Lys Pro Ala Ala
     130                 135                 140

 cct ttc cca cgt ggg gag ctg gag tct ccc aag ccc ctg gtg acc cct      596
 Pro Phe Pro Arg Gly Glu Leu Glu Ser Pro Lys Pro Leu Val Thr Pro
 145                 150                 155                 160

 ggt agc aca ctt act ctg ctg acc agg gct gag gct gga agc ccc aca      644
 Gly Ser Thr Leu Thr Leu Leu Thr Arg Ala Glu Ala Gly Ser Pro Thr
                 165                 170                 175

 ggt gga ctc ttc aac acg cca cca ccc aca ccc cca gag cag gac aaa      692
 Gly Gly Leu Phe Asn Thr Pro Pro Pro Thr Pro Pro Glu Gln Asp Lys
             180                 185                 190

 gag gac ttc agc agc ttc cag ctg ctg gtg gag gtg gcg cta cag agg      740
 Glu Asp Phe Ser Ser Phe Gln Leu Leu Val Glu Val Ala Leu Gln Arg
         195                 200                 205

 gct gct gag atg gag ctt cag aag cag cag gac cca tca ctc cca tta      788
 Ala Ala Glu Met Glu Leu Gln Lys Gln Gln Asp Pro Ser Leu Pro Leu
     210                 215                 220

 ctg cac act ccc atc cct tta gtc tct gaa aat ccc cag cct ccg ctc      836
 Leu His Thr Pro Ile Pro Leu Val Ser Glu Asn Pro Gln Pro Pro Leu
 225                 230                 235                 240

 agt gat gag acc aag aga tcg gag aca agc atg gtg ctg ctg ctt ctg      884
 Ser Asp Glu Thr Lys Arg Ser Glu Thr Ser Met Val Leu Leu Leu Leu
                 245                 250                 255

 ctg ctt ctc cag aaa atc cct ggg aca cct ttg ttc cag cct ggt ttc      932
 Leu Leu Leu Gln Lys Ile Pro Gly Thr Pro Leu Phe Gln Pro Gly Phe
             260                 265                 270

 ctg ggc tgg gct cag gaa agc tgc caa att cag tcc tat gtt ggg tcc      980
 Leu Gly Trp Ala Gln Glu Ser Cys Gln Ile Gln Ser Tyr Val Gly Ser
         275                 280                 285

 aag ctg ccc ctg tgc tgt ttc tgt caa gcc agg tgt gga cat tcc aag     1028
 Lys Leu Pro Leu Cys Cys Phe Cys Gln Ala Arg Cys Gly His Ser Lys
     290                 295                 300

 ttc ata tgc gtg aac aaa aga aaa gag gaa ccc agt gga tgt aac aga     1076
 Phe Ile Cys Val Asn Lys Arg Lys Glu Glu Pro Ser Gly Cys Asn Arg
 305                 310                 315                 320

 acc gac tcc agt tga atgtttagat ttttgctaaa ctgttttctt tttccctttt     1131
 Thr Asp Ser Ser 


 ttgctgtggt ttgcattcac ggcagtagtt agcccaggtg tggggaacga gagtgcactg   1191

 catgatagcg ttctggtgag ctgggaagga cccaccactg ccactgagga ttgttttgga   1251

 agaaaggaat atttttatct tggggaccag ctaagtctct gcagtagtgt gaaattccaa   1311

 atggttgttt tatcattggt ttggtttacc aaaaaaaagg cagggaaaaa aaaaaaaaac   1371

 aaccgtatga gcgcattggc ttgtctgccg ccnccaagaa aggggtagaa agcccacagc   1431

 aggggggcag tccagcagac tctgactcaa ctttntaggc ccctagcnga gaaagataag   1491

 ttccaaaggt gttttggttt tcctttaatt ttaatcggag tttttttggg tggggtgggg   1551

 gaagtaaact agnctgagcg                                               1571




      <210> 206
      <211> 1596
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (19)..(936)

      <400> 206
 aggaaaaggc gctccgtc  atg ggg atc cag acg agc ccc gtc ctg ctg gcc      51
                      Met Gly Ile Gln Thr Ser Pro Val Leu Leu Ala
                        1               5                  10

 tcc ctg ggg gtg ggg ctg gtc act ctg ctc ggc ctg gct gtg ggc tcc       99
 Ser Leu Gly Val Gly Leu Val Thr Leu Leu Gly Leu Ala Val Gly Ser
              15                  20                  25

 tac ttg gtt cgg agg tcc cgc cgg cct cag gtc act ctc ctg gac ccc      147
 Tyr Leu Val Arg Arg Ser Arg Arg Pro Gln Val Thr Leu Leu Asp Pro
          30                  35                  40

 aat gaa aag tac ctg cta cga ctg cta gac aag acg act gtg agc cac      195
 Asn Glu Lys Tyr Leu Leu Arg Leu Leu Asp Lys Thr Thr Val Ser His
      45                  50                  55

 aac acc aag agg ttc cgc ttt gcc ctg ccc acc gcc cac cac act ctg      243
 Asn Thr Lys Arg Phe Arg Phe Ala Leu Pro Thr Ala His His Thr Leu
  60                  65                  70                  75

 ggg ctg cct gtg ggc aaa cat atc tac ctc tcc acc cga att gat ggc      291
 Gly Leu Pro Val Gly Lys His Ile Tyr Leu Ser Thr Arg Ile Asp Gly
                  80                  85                  90

 agc ctg gtc atc agg cca tac act cct gtc acc agt gat gag gat caa      339
 Ser Leu Val Ile Arg Pro Tyr Thr Pro Val Thr Ser Asp Glu Asp Gln
              95                 100                 105

 ggc tat gtg gat ctt gtc atc aag gtc tac ctg aag ggt gtg cac ccc      387
 Gly Tyr Val Asp Leu Val Ile Lys Val Tyr Leu Lys Gly Val His Pro
         110                 115                 120

 aaa ttt cct gag gga ggg aag atg tct cag tac ctg gat agc ctg aag      435
 Lys Phe Pro Glu Gly Gly Lys Met Ser Gln Tyr Leu Asp Ser Leu Lys
     125                 130                 135

 gtt ggg gat gtg gtg gag ttt cgg ggg cca agc ggg ttg ctc act tac      483
 Val Gly Asp Val Val Glu Phe Arg Gly Pro Ser Gly Leu Leu Thr Tyr
 140                 145                 150                 155

 act gga aaa ggg cat ttt aac att cag ccc aac aag aaa tct cca cca      531
 Thr Gly Lys Gly His Phe Asn Ile Gln Pro Asn Lys Lys Ser Pro Pro
                 160                 165                 170

 gaa ccc cga gtg gcg aag aaa ctg gga atg att gcc ggc ggg aca gga      579
 Glu Pro Arg Val Ala Lys Lys Leu Gly Met Ile Ala Gly Gly Thr Gly
             175                 180                 185

 atc acc cca atg cta cag ctg atc cgg gcc atc ctg aaa gtc cct gaa      627
 Ile Thr Pro Met Leu Gln Leu Ile Arg Ala Ile Leu Lys Val Pro Glu
         190                 195                 200

 gat cca acc cag tgc ttt ctg ctt ttt gcc aac cag aca gaa aag gat      675
 Asp Pro Thr Gln Cys Phe Leu Leu Phe Ala Asn Gln Thr Glu Lys Asp
     205                 210                 215

 atc atc ttg cgg gag gac tta gag gaa ctg cag gcc cgc tat ccc aat      723
 Ile Ile Leu Arg Glu Asp Leu Glu Glu Leu Gln Ala Arg Tyr Pro Asn
 220                 225                 230                 235

 cgc ttt aag ctc tgg ttc act ctg gat cat ccc cca aaa gat tgg gcc      771
 Arg Phe Lys Leu Trp Phe Thr Leu Asp His Pro Pro Lys Asp Trp Ala
                 240                 245                 250

 tac agc aag ggc ttt gtg act gcc gac atg atc cgg gaa cac ctg ccc      819
 Tyr Ser Lys Gly Phe Val Thr Ala Asp Met Ile Arg Glu His Leu Pro
             255                 260                 265

 gct cca ggg gat gat gtg ctg gta ctg ctt tgt ggg cca ccc cca atg      867
 Ala Pro Gly Asp Asp Val Leu Val Leu Leu Cys Gly Pro Pro Pro Met
         270                 275                 280

 gtg cag ctg gcc tgc cat ccc aac ttg gac aaa ctg ggc tac tca caa      915
 Val Gln Leu Ala Cys His Pro Asn Leu Asp Lys Leu Gly Tyr Ser Gln
     285                 290                 295

 aag atg cga ttc acc tac tga gc atcctccagc ttccctggtg ctgttcgctg      968
 Lys Met Arg Phe Thr Tyr 
 300                 305

 cagttgttcc ccatcagtac tcaagcacta taagccttag attcctttcc tcagagtttc   1028

 aggttttttc agttacatct agagctgaaa tctggatagt acctgcagga acaatattcc   1088

 tgtagccatg gaagagggcc aaggctcagt cactccttgg atggcctcct aaatctcccc   1148

 gtggcaacag gtccaggaga ggcccatgga gcagtctctt ccatggagta agaaggaagg   1208

 gagcatgtac gcttggtcca agattggcta gttccttgat agcatcttac tctcaccttc   1268

 tttgtgtctg tgatgaaagg aacagtctgt gcaatgggtt ttacttaaac ttcactgttc   1328

 aacctatgag caaatctgta tgtgtgagta taagttgagc atagcatact tccagaggtg   1388

 gtcttatgga gatggcaaga aaggaggaaa tgatttcttc agatctcaaa ggagtctgaa   1448

 atatcatatt tctgtgtgtg tctctctcag cccctgccca ggctagaggg aaacagctac   1508

 tgataatcga aaactgctgt ttgtggcagg aacccctggc tgtgcaaata aatggggctg   1568

 aggcccctgt gtgatattga aaaaaaaa                                      1596




      <210> 207
      <211> 1583
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (304)..(903)

      <220>
      <221> misc_feature
      <222> (1)...(1583)
      <223> n = a,t,c or g

      <400> 207
 ggcctgaagt acccaagtcc ccgagggcgc gccttccccg ggaatttaat tcaggacaat     60

 aatgttttat tgagcgccta ttgtgaatca gacactgagc agtaagcgtc ggagaaacag    120

 gtgaatgata ccggggaaaa gtcattccct gtgtgtagcg tctagggcag cctttgccct    180

 ggttccagca gatgggttgt ctcttcatag tctatgcatt tctgaagacc ccacggtgaa    240

 gggctgcaag gatgaagctg tcccagagta tctccagagt gcaaatccct tggctgccag    300

 gtc  atg ttc tct ctt cct ctc aac tgc tct ccc gac cat ata agg aga     348
      Met Phe Ser Leu Pro Leu Asn Cys Ser Pro Asp His Ile Arg Arg
        1               5                  10                  15

 ggc agc tgc tgg ggg cgt ccc cag gat cta aag ata gcg gcc cct gcc      396
 Gly Ser Cys Trp Gly Arg Pro Gln Asp Leu Lys Ile Ala Ala Pro Ala
                  20                  25                  30

 tgg aac tct aaa tgc cac cct gga gcg gga gcc gca atg gca cgg cag      444
 Trp Asn Ser Lys Cys His Pro Gly Ala Gly Ala Ala Met Ala Arg Gln
              35                  40                  45

 cac gcc cgg acc ttg tgg tac gac agg ccc atg tat gtg ttc atg gag      492
 His Ala Arg Thr Leu Trp Tyr Asp Arg Pro Met Tyr Val Phe Met Glu
          50                  55                  60

 ttt tgt gtt gag gac agc acc gat gtc cac gtg ctt att gag gat cac      540
 Phe Cys Val Glu Asp Ser Thr Asp Val His Val Leu Ile Glu Asp His
      65                  70                  75

 cgc att gtg ttc agc tgc aag aat gcc gat gga gtg gag ttg tac aat      588
 Arg Ile Val Phe Ser Cys Lys Asn Ala Asp Gly Val Glu Leu Tyr Asn
  80                  85                  90                  95

 gag att gag ttc tat gcc aaa gtg aac tcc aag gac tcc cag gat aag      636
 Glu Ile Glu Phe Tyr Ala Lys Val Asn Ser Lys Asp Ser Gln Asp Lys
                 100                 105                 110

 cgc tct tcc cgc tct att act tgt ttt gtg aga aaa tgg aag gaa aag      684
 Arg Ser Ser Arg Ser Ile Thr Cys Phe Val Arg Lys Trp Lys Glu Lys
             115                 120                 125

 gtg gcc tgg ccg cgg ctt acc aag gag gat atc aag cca gtg tgg ctg      732
 Val Ala Trp Pro Arg Leu Thr Lys Glu Asp Ile Lys Pro Val Trp Leu
         130                 135                 140

 tct gtg gac ttt gat aac tgg aga gac tgg gaa ggg gat gaa gag atg      780
 Ser Val Asp Phe Asp Asn Trp Arg Asp Trp Glu Gly Asp Glu Glu Met
     145                 150                 155

 gag ctg gct cat gtg gaa cat tat gca gag ctt ttg aag aag gtc agc      828
 Glu Leu Ala His Val Glu His Tyr Ala Glu Leu Leu Lys Lys Val Ser
 160                 165                 170                 175

 acc aag aga cct cca cct gcc atg gat gat ttg gat gat gat tct gac      876
 Thr Lys Arg Pro Pro Pro Ala Met Asp Asp Leu Asp Asp Asp Ser Asp
                 180                 185                 190

 agt gct gat gat gca aca agt aat taa ctttc tgtgacgcaa agctgggaag      928
 Ser Ala Asp Asp Ala Thr Ser Asn 
             195

 gcagctgtgg ctattttcca gttgttctag aaagctagcg cctaggcctt tgtcagcgct    988

 ttggctgtgc accaagttct tctgagatct ctgaactttc ctagaagctc tttattaagg   1048

 gtcgtccttc aagcttgtct tcctcctagg cacttgacta tggctccaca tcagatgcag   1108

 ggtcggggag gggtagactg gtagggcttc tgatttctta ctgattggtt tctaatctct   1168

 gtgtttaggc cacttgatta tttgagtatg tgtgtgtatg tggcaaaaca aaagccaaag   1228

 aagaatgcag attatagaaa tctctactat gtgtgcatat ggggcaaagc aaaaagccaa   1288

 agaagaaaca gattataata aatctctagg aactgttctc tgtctgtttc cttcttgtac   1348

 ttattcctcc tggtggcaag cctcttctcc ctctagtaac caagctgggg tgcttcctct   1408

 tgcccagatt tgtgctctga tttcttacag ctaattctgg tcatctctag aaccagccac   1468

 ttcagcttcc tgcacactct agaaatctct ttatactttt tttttttntt ttttccgaga   1528

 tggagtcttg ctctgtcgcc caggctggag tgcagtggtg cagtctctgt tcact        1583




      <210> 208
      <211> 973
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (48)..(686)

      <400> 208
 atttggccct cgaggcaaga attcggcacg aggtatctgt ggacctt  atg gaa gca      56
                                                      Met Glu Ala
                                                        1

 aag act ctt gga act gta acg ccc aga aaa cct gtc tta tct gtc agt      104
 Lys Thr Leu Gly Thr Val Thr Pro Arg Lys Pro Val Leu Ser Val Ser
       5                  10                  15

 gca aga aaa att aag gac aat gcg gct gat tgg cac aat tta atc ctg      152
 Ala Arg Lys Ile Lys Asp Asn Ala Ala Asp Trp His Asn Leu Ile Leu
  20                  25                  30                  35

 aag tgg gaa acc ctc aat gat gca ggt ttt acc act gca aat aat att      200
 Lys Trp Glu Thr Leu Asn Asp Ala Gly Phe Thr Thr Ala Asn Asn Ile
                  40                  45                  50

 gcc aac ttg aaa atc agt tta ttg aat aaa gac aag ata gaa cta gac      248
 Ala Asn Leu Lys Ile Ser Leu Leu Asn Lys Asp Lys Ile Glu Leu Asp
              55                  60                  65

 agc agc agc cca gcc tcg aag gaa aat gaa gaa aag gtg tgt ctg gaa      296
 Ser Ser Ser Pro Ala Ser Lys Glu Asn Glu Glu Lys Val Cys Leu Glu
          70                  75                  80

 tat aac gag gaa ctg gag aag ctg tgt gag gaa ctg cag gcc acc ttg      344
 Tyr Asn Glu Glu Leu Glu Lys Leu Cys Glu Glu Leu Gln Ala Thr Leu
      85                  90                  95

 gat ggg ttg acc aaa ata cag gtg aaa atg gaa aag ctg tct tca act      392
 Asp Gly Leu Thr Lys Ile Gln Val Lys Met Glu Lys Leu Ser Ser Thr
 100                 105                 110                 115

 acc aag gga att tgt gaa cta gaa aac tac cat tat ggg gag gag agt      440
 Thr Lys Gly Ile Cys Glu Leu Glu Asn Tyr His Tyr Gly Glu Glu Ser
                 120                 125                 130

 aaa cga ccc cct ctg ttc cac acg tgg cct aca acc cat ttc tat gag      488
 Lys Arg Pro Pro Leu Phe His Thr Trp Pro Thr Thr His Phe Tyr Glu
             135                 140                 145

 gtt tcg cat aag ctc ttg gag atg tac agg aag gag ctg ctc ctg aag      536
 Val Ser His Lys Leu Leu Glu Met Tyr Arg Lys Glu Leu Leu Leu Lys
         150                 155                 160

 cgc acg gtg gcc aag gag ctt gcc cac acc ggg gat ccc gac ctc acc      584
 Arg Thr Val Ala Lys Glu Leu Ala His Thr Gly Asp Pro Asp Leu Thr
     165                 170                 175

 ctg agc tac ctg tcc atg tgg ctg cac cag ccc tat gtg gag agc gac      632
 Leu Ser Tyr Leu Ser Met Trp Leu His Gln Pro Tyr Val Glu Ser Asp
 180                 185                 190                 195

 agc agg ctg cat ctg gag agc atg ctg ctg gag aca ggc cac cga gct      680
 Ser Arg Leu His Leu Glu Ser Met Leu Leu Glu Thr Gly His Arg Ala
                 200                 205                 210

 ctc tga cgtcctgaga cggctgcgga cactggctcc ttccacgtct caccaggcag       736
 Leu 


 acagtttgcc taggacccag tgccgcaggc ctggatcaga ccccaggatc agaccttttt    796

 ggggtttttt ggccagagct tgtcaccagc cccatggcct ctccaggggt gctcatgccc    856

 acaacccgcg gccagcccca cgtggtgccg ctcagccttt tttgcccctc ctgggaatct    916

 gtcattcgtg ggtgcttcag agtaaaatca atgagttttt gagcaaaaaa aaaaaaa       973




      <210> 209
      <211> 1504
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (242)..(1453)

      <400> 209
 tcatcgcata gggcggggct cgtacctgac gcccggcttc tgggcctgct ctcgccctac     60

 tagggaaagg ggtggggctt ggctttcggg cgtgggcgga aattgccgag aatcctcgga    120

 agctttgcga aaacacagcg cgccgtcggc cgcgctgcga accggaagta atcgaagaag    180

 ccccggaagt ttcgaactac caccggcgtg cgttcgcagg tagatcgcgg tgccagttgc    240

 c    atg gag ccg gcc ggg ccc tgt ggc ttc tgc ccg gcg ggg gag gtc     286
      Met Glu Pro Ala Gly Pro Cys Gly Phe Cys Pro Ala Gly Glu Val
        1               5                  10                  15

 cag cca gcg cgt tac acc tgc cct cgc tgt aat gcg ccc tac tgc tcg      334
 Gln Pro Ala Arg Tyr Thr Cys Pro Arg Cys Asn Ala Pro Tyr Cys Ser
                  20                  25                  30

 ctg cgc tgc tac cgg acg cat ggc acc tgc gca gaa aac ttc tac cgt      382
 Leu Arg Cys Tyr Arg Thr His Gly Thr Cys Ala Glu Asn Phe Tyr Arg
              35                  40                  45

 gac cag gtg ctg gga gag ctc cgc ggt tgc agc gct cct ccc agc cgc      430
 Asp Gln Val Leu Gly Glu Leu Arg Gly Cys Ser Ala Pro Pro Ser Arg
          50                  55                  60

 cta gca agc gcc cta cgc cgg ctg cgt cag caa cgc gag acc gag gac      478
 Leu Ala Ser Ala Leu Arg Arg Leu Arg Gln Gln Arg Glu Thr Glu Asp
      65                  70                  75

 gag cct ggg gaa gca ggc ctc agc tcc ggc ccg gcg ccc ggc ggc cta      526
 Glu Pro Gly Glu Ala Gly Leu Ser Ser Gly Pro Ala Pro Gly Gly Leu
  80                  85                  90                  95

 tcg gga ctc tgg gag cgg ctg gcg ccg ggc gaa aaa gct gcc ttc gag      574
 Ser Gly Leu Trp Glu Arg Leu Ala Pro Gly Glu Lys Ala Ala Phe Glu
                 100                 105                 110

 cgg ctg ctg agc cgc ggt gag gcc ggg cgg ctg ctg cct cca tgg cgg      622
 Arg Leu Leu Ser Arg Gly Glu Ala Gly Arg Leu Leu Pro Pro Trp Arg
             115                 120                 125

 ccg tgg tgg tgg aac cgc gga gcc gga ccg cag ctt ctg gag gag ctg      670
 Pro Trp Trp Trp Asn Arg Gly Ala Gly Pro Gln Leu Leu Glu Glu Leu
         130                 135                 140

 gat aat gcc ccg ggt agt gac gcc gcg gag ctg gag ctc gcc cct gcg      718
 Asp Asn Ala Pro Gly Ser Asp Ala Ala Glu Leu Glu Leu Ala Pro Ala
     145                 150                 155

 agg acc ccg ccg gat tct gtg aaa gat gcc tcc gcc gcg gag ccc gcg      766
 Arg Thr Pro Pro Asp Ser Val Lys Asp Ala Ser Ala Ala Glu Pro Ala
 160                 165                 170                 175

 gcc gcc gag cgg gtt ctt gga gat gtc ccg ggg gcc tgc acg ccc gtc      814
 Ala Ala Glu Arg Val Leu Gly Asp Val Pro Gly Ala Cys Thr Pro Val
                 180                 185                 190

 gta ccc acc cgc atc ccc gcg ata gtc agc ctg agc cgc ggc cca gtc      862
 Val Pro Thr Arg Ile Pro Ala Ile Val Ser Leu Ser Arg Gly Pro Val
             195                 200                 205

 tcg ccg ctc gtg cgc ttc cag ctg ccc aat gtg ctg ttc gcc tac gcg      910
 Ser Pro Leu Val Arg Phe Gln Leu Pro Asn Val Leu Phe Ala Tyr Ala
         210                 215                 220

 cat act ctc gcc ctg tat cac ggc ggt gac gac gcg ctg ctc tct gac      958
 His Thr Leu Ala Leu Tyr His Gly Gly Asp Asp Ala Leu Leu Ser Asp
     225                 230                 235

 ttc tgt gcc aca ctg ctc ggc gtt tcc gga gcc ctg ggt gcc cag caa     1006
 Phe Cys Ala Thr Leu Leu Gly Val Ser Gly Ala Leu Gly Ala Gln Gln
 240                 245                 250                 255

 gtc ttc gcc tct gcg gaa gaa gcc ctg cag gcg gca gcc cac gtg ctg     1054
 Val Phe Ala Ser Ala Glu Glu Ala Leu Gln Ala Ala Ala His Val Leu
                 260                 265                 270

 gaa gca ggc gag cac ccg ccg ggg ccc ctg ggc aca cga ggg gct atg     1102
 Glu Ala Gly Glu His Pro Pro Gly Pro Leu Gly Thr Arg Gly Ala Met
             275                 280                 285

 cac gag gtc gcc cgc atc ctg ctg ggc gag ggc ccg acc aac cag aaa     1150
 His Glu Val Ala Arg Ile Leu Leu Gly Glu Gly Pro Thr Asn Gln Lys
         290                 295                 300

 ggc tac acg ctg gca gca ctg ggg gac ctg gca cag acc ctg ggc cgt     1198
 Gly Tyr Thr Leu Ala Ala Leu Gly Asp Leu Ala Gln Thr Leu Gly Arg
     305                 310                 315

 gcc cgg aaa cag gcc gtg gct aga gaa gag cga gat cat ctt tac cgg     1246
 Ala Arg Lys Gln Ala Val Ala Arg Glu Glu Arg Asp His Leu Tyr Arg
 320                 325                 330                 335

 gcc cgg aaa aag tgc cag ttc ctc ctg gcc tgg acc aac gaa aat gag     1294
 Ala Arg Lys Lys Cys Gln Phe Leu Leu Ala Trp Thr Asn Glu Asn Glu
                 340                 345                 350

 gcg gcc ctc aca ccc ctg gct cta gac tgc gcc agg gct cac caa gcc     1342
 Ala Ala Leu Thr Pro Leu Ala Leu Asp Cys Ala Arg Ala His Gln Ala
             355                 360                 365

 cat gct gtg gta gcc gag gag gtg gcc gcc ctc act ggg gag ctg gag     1390
 His Ala Val Val Ala Glu Glu Val Ala Ala Leu Thr Gly Glu Leu Glu
         370                 375                 380

 cgg ctt tgg gga ggc ccc gtg cca cct gcc cca aga act ctc att gag     1438
 Arg Leu Trp Gly Gly Pro Val Pro Pro Ala Pro Arg Thr Leu Ile Glu
     385                 390                 395

 gag ctc cct agc tga acgggttacc ctggtcatta ataaagctgt gactggtcaa     1493
 Glu Leu Pro Ser 
 400

 aaaaaaaaaa a                                                        1504




      <210> 210
      <211> 1030
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (172)..(711)

      <400> 210
 aaggatcctt aattaaatta atcccccccc cccgggcggc gtctggcgtg gagagtttgg     60

 ggatctacag cagccaaagg cttgtccctg actttatatg gctgcgcctg gcgagcgact    120

 gagtcgtccg tgaggaaaaa gaggcgaggc ttttccgaga tcgtctcagc g atg gcg     177
                                                          Met Ala
                                                            1

 ctt cgg tcg cag ttt tgg ggg ttc tcg gtt tgc agg aac cct ggg tgc      225
 Leu Arg Ser Gln Phe Trp Gly Phe Ser Val Cys Arg Asn Pro Gly Cys
           5                  10                  15

 agg ttc gca gcc ctg tca acc agc tcc gag ccg gca gcg aaa cct gaa      273
 Arg Phe Ala Ala Leu Ser Thr Ser Ser Glu Pro Ala Ala Lys Pro Glu
      20                  25                  30

 gtg gac cct gtg gaa aat gaa gct gtc gcc cca gaa ttc acc aac cgg      321
 Val Asp Pro Val Glu Asn Glu Ala Val Ala Pro Glu Phe Thr Asn Arg
  35                  40                  45                  50

 aac ccc cgg aac ctg gag ctt tta tct gta gcc agg aaa gag cgg ggc      369
 Asn Pro Arg Asn Leu Glu Leu Leu Ser Val Ala Arg Lys Glu Arg Gly
                  55                  60                  65

 tgg cgg acg gtg ttt ccc tcc cgt gag ttc tgg cac agg ttg cga gtt      417
 Trp Arg Thr Val Phe Pro Ser Arg Glu Phe Trp His Arg Leu Arg Val
              70                  75                  80

 ata agg act cag cat cat gta gaa gca ctt gtg gag cat cag aat ggc      465
 Ile Arg Thr Gln His His Val Glu Ala Leu Val Glu His Gln Asn Gly
          85                  90                  95

 aag gtt gtg gtt tcg gcc tcc act cgt gag tgg gct att aaa aag cac      513
 Lys Val Val Val Ser Ala Ser Thr Arg Glu Trp Ala Ile Lys Lys His
     100                 105                 110

 ctt tat agt acc aga aat gtg gtg gct tgt gag agt ata gga cga gtg      561
 Leu Tyr Ser Thr Arg Asn Val Val Ala Cys Glu Ser Ile Gly Arg Val
 115                 120                 125                 130

 ctg gca cag aga tgc tta gag gcg gga atc aac ttc atg gtc tac caa      609
 Leu Ala Gln Arg Cys Leu Glu Ala Gly Ile Asn Phe Met Val Tyr Gln
                 135                 140                 145

 cca acc ccg tgg gag gca gcc tca gac tcg atg aaa cga cta caa agt      657
 Pro Thr Pro Trp Glu Ala Ala Ser Asp Ser Met Lys Arg Leu Gln Ser
             150                 155                 160

 gcc atg aca gaa ggt ggt gtg gtt cta cgg gaa cct cag aga atc tat      705
 Ala Met Thr Glu Gly Gly Val Val Leu Arg Glu Pro Gln Arg Ile Tyr
         165                 170                 175

 gaa taa atggaagcat taattgtttt gaacatgtaa atataaatct gtcagccact       761
 Glu 


 acagccatca aaagagagca tctggaagaa cagccagctt ggaagtttta cagcaataat    821

 gttgcagtgg aatattattt gtagttaagg tcatcctcct cccctttctg tttttttaaa    881

 tcaagaacta cgttctgccc ctctcttggg cttcagaagc atctaagaaa agcagtcatc    941

 aattataatt aactttcaaa gggcaagtca gaagttgttt ataaattaca aaataaaggc   1001

 atattatgaa ctcttaaaaa aaaaaaaaa                                     1030




      <210> 211
      <211> 1808
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (234)..(1589)

      <400> 211
 gcacgagggc ggaattccag ctgcgactgc tgagggagaa aatgatgccc aggttgggct     60

 ccccggccca ccggccgagg agaggcctgc gctgcacacg cgcagaccga gcatccgcgt    120

 caagaggcga agagagcgcg cgctccccac gtcctgcgct cctggctgcc gggcattcgt    180

 ctcagccgtg actctcgcca ggccggggct ggcgcgccca cgtctgaaga gcg   atg     236
                                                              Met
                                                                1

 ccc cgg gag atc atc acc ctg cag ctg ggc cag tgc ggc aac cag att      284
 Pro Arg Glu Ile Ile Thr Leu Gln Leu Gly Gln Cys Gly Asn Gln Ile
               5                  10                  15

 ggg ttc gag ttc tgg aaa cag ctg tgc gcc gag cat ggt atc agc ccc      332
 Gly Phe Glu Phe Trp Lys Gln Leu Cys Ala Glu His Gly Ile Ser Pro
          20                  25                  30

 gag ggc atc gtg gag gag ttc gcc acc gag ggc act gac cgc aag gac      380
 Glu Gly Ile Val Glu Glu Phe Ala Thr Glu Gly Thr Asp Arg Lys Asp
      35                  40                  45

 gtc ttt ttc tac cag gca gac gat gag cac tac atc ccc cgg gcc gtg      428
 Val Phe Phe Tyr Gln Ala Asp Asp Glu His Tyr Ile Pro Arg Ala Val
  50                  55                  60                  65

 ctg ctg gac ttg gaa ccc cgg gtg atc cac tcc atc ctc aac tcc ccc      476
 Leu Leu Asp Leu Glu Pro Arg Val Ile His Ser Ile Leu Asn Ser Pro
                  70                  75                  80

 tat gcc aag ctc tac aac cca gag aac atc tac ctg tcg gaa cat gga      524
 Tyr Ala Lys Leu Tyr Asn Pro Glu Asn Ile Tyr Leu Ser Glu His Gly
              85                  90                  95

 gga gga gct ggc aac aac tgg gcc agc gga ttc tcc cag ggt gag aaa      572
 Gly Gly Ala Gly Asn Asn Trp Ala Ser Gly Phe Ser Gln Gly Glu Lys
         100                 105                 110

 att cat gaa gac atc ttt gac atc ata gac cga gaa gca gat gga agt      620
 Ile His Glu Asp Ile Phe Asp Ile Ile Asp Arg Glu Ala Asp Gly Ser
     115                 120                 125

 gac agt ttg gag ggc ttc gtg ctg tgt cac tcc atc gct ggg ggt acg      668
 Asp Ser Leu Glu Gly Phe Val Leu Cys His Ser Ile Ala Gly Gly Thr
 130                 135                 140                 145

 ggt tct ggc ctg ggc tcc tac ctc ctg gag cga ctg aat gac agg tac      716
 Gly Ser Gly Leu Gly Ser Tyr Leu Leu Glu Arg Leu Asn Asp Arg Tyr
                 150                 155                 160

 ccc aag aag cta gtg cag act tat tca gtg ttt ccc tac cag gac gag      764
 Pro Lys Lys Leu Val Gln Thr Tyr Ser Val Phe Pro Tyr Gln Asp Glu
             165                 170                 175

 atg agc gac gta gtg gtt cag ccc tac aat tca ctc ctg aca ctc aag      812
 Met Ser Asp Val Val Val Gln Pro Tyr Asn Ser Leu Leu Thr Leu Lys
         180                 185                 190

 agg ctg acg cag aac gca gat tgt gtg gtg gtg ctg gac aac aca gcc      860
 Arg Leu Thr Gln Asn Ala Asp Cys Val Val Val Leu Asp Asn Thr Ala
     195                 200                 205

 ctg aac cgg att gcc aca gac cgc ctg cac atc cag aac ccg tcc ttc      908
 Leu Asn Arg Ile Ala Thr Asp Arg Leu His Ile Gln Asn Pro Ser Phe
 210                 215                 220                 225

 tcc cag atc aac cag ctg gtg tcc acc atc atg tcg gcc agc acc acc      956
 Ser Gln Ile Asn Gln Leu Val Ser Thr Ile Met Ser Ala Ser Thr Thr
                 230                 235                 240

 acc ctg cgc tac ccc ggc tac atg aac aat gac ctc atc ggc ctc atc     1004
 Thr Leu Arg Tyr Pro Gly Tyr Met Asn Asn Asp Leu Ile Gly Leu Ile
             245                 250                 255

 gcc tcg ctc att ccc acc cca cgg ctc cac ttc ctc atg acc ggc tac     1052
 Ala Ser Leu Ile Pro Thr Pro Arg Leu His Phe Leu Met Thr Gly Tyr
         260                 265                 270

 acc ccg ctc act aca gac cag tca gtg gcc agc gtg agg aag acc acg     1100
 Thr Pro Leu Thr Thr Asp Gln Ser Val Ala Ser Val Arg Lys Thr Thr
     275                 280                 285

 gtc ctg gat gtc atg agg cgg ctg ctg cag ccc aag aac gtg atg gtg     1148
 Val Leu Asp Val Met Arg Arg Leu Leu Gln Pro Lys Asn Val Met Val
 290                 295                 300                 305

 tcc aca ggc cga gac cgc cag acc aac cac tgc tac atc gcc atc ctc     1196
 Ser Thr Gly Arg Asp Arg Gln Thr Asn His Cys Tyr Ile Ala Ile Leu
                 310                 315                 320

 aac atc atc cag gga gag gtg gac ccc acc cag gtc cac aag agc ctg     1244
 Asn Ile Ile Gln Gly Glu Val Asp Pro Thr Gln Val His Lys Ser Leu
             325                 330                 335

 cag agg atc cgg gaa cgg aag ttg gcc aac ttc atc ccg tgg ggc ccc     1292
 Gln Arg Ile Arg Glu Arg Lys Leu Ala Asn Phe Ile Pro Trp Gly Pro
         340                 345                 350

 gcc agc atc cag gtg gcc ctg tcg agg aag tct ccc tac ctg ccc tcg     1340
 Ala Ser Ile Gln Val Ala Leu Ser Arg Lys Ser Pro Tyr Leu Pro Ser
     355                 360                 365

 gcc cac cgg gtc agc ggg ctc atg atg gcc aac cac acc agc atc tcc     1388
 Ala His Arg Val Ser Gly Leu Met Met Ala Asn His Thr Ser Ile Ser
 370                 375                 380                 385

 tcg ctc ttt gaa agt tcc tgc cag cag ttt gac aag ctg cgg aag cgg     1436
 Ser Leu Phe Glu Ser Ser Cys Gln Gln Phe Asp Lys Leu Arg Lys Arg
                 390                 395                 400

 gat gcc ttc ctc gag cag ttc cgt aag gag gac atg ttc aag gac acc     1484
 Asp Ala Phe Leu Glu Gln Phe Arg Lys Glu Asp Met Phe Lys Asp Thr
             405                 410                 415

 ttt gat gag atg gac agg tct agg gag gtt gtt cag gag ctc att gat     1532
 Phe Asp Glu Met Asp Arg Ser Arg Glu Val Val Gln Glu Leu Ile Asp
         420                 425                 430

 gag tac cat gcg gcc acc cag cca gac tac att tcc tgg ggc acc cag     1580
 Glu Tyr His Ala Ala Thr Gln Pro Asp Tyr Ile Ser Trp Gly Thr Gln
     435                 440                 445

 gag cag tga tttcccc tccccactac tccttctcct tctagatggt aaccacagcc     1636
 Glu Gln 
 450

 tcgaccatgc ctgctccctc tgacccagct tcacctcatg gacaaccctt cttggttcat   1696

 ctccagcccg tgagctggtc ctgcttcctc ccttccatgc cctaactttt aatatgcttg   1756

 ttcagctcta ataaagtaat aaagcttggt tgtcagtata aaaaaaaaaa aa           1808




      <210> 212
      <211> 6482
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (330)..(5801)

      <400> 212
 gactcaccgt ctgaaaagcc agcttaaagt gggagggcct gggagtagaa ggtaaaaagg     60

 gagtggtgag aatgaatgtg agaaggaagc caggacagcg cagtccccag tcccgaacgg    120

 ccagggagag gaggtggcct agcgctggcg gggctcaccc caatccgtct gccttttgat    180

 gccgtactct gctggttgcg cagccacctc gggatactgc acacggagag gagggaaaat    240

 aagcgaggca ccgccgcacc acgcgggaga cctacggaga cccacagcgc ccgagccctg    300

 gaagagcact actggatgtc agcggagaa  atg gct ttg agc tca gcc tgg cgc     353
                                  Met Ala Leu Ser Ser Ala Trp Arg
                                    1               5

 tcg gtt ctg cct ctg tgg ctc ctc tgg agc gct gcc tgc tcc cgc gcc      401
 Ser Val Leu Pro Leu Trp Leu Leu Trp Ser Ala Ala Cys Ser Arg Ala
      10                  15                  20

 gcg tcc ggg gac gac aac gct ttt cct ttt gac att gaa ggg agc tca      449
 Ala Ser Gly Asp Asp Asn Ala Phe Pro Phe Asp Ile Glu Gly Ser Ser
  25                  30                  35                  40

 gcg gtt ggc agg caa gac ccg cct gag acg agc gaa ccc cgc gtg gct      497
 Ala Val Gly Arg Gln Asp Pro Pro Glu Thr Ser Glu Pro Arg Val Ala
                  45                  50                  55

 ctg gga cgc ctg ccg cct gcg gcc gag aaa tgc aat gct gga ttc ttt      545
 Leu Gly Arg Leu Pro Pro Ala Ala Glu Lys Cys Asn Ala Gly Phe Phe
              60                  65                  70

 cac acc ctg tcg gga gaa tgt gtg ccc tgc gac tgt aat ggc aat tcc      593
 His Thr Leu Ser Gly Glu Cys Val Pro Cys Asp Cys Asn Gly Asn Ser
          75                  80                  85

 aac gag tgt ttg gac ggc tca gga tac tgt gtg cac tgc cag cgg aac      641
 Asn Glu Cys Leu Asp Gly Ser Gly Tyr Cys Val His Cys Gln Arg Asn
      90                  95                 100

 aca aca gga gag cac tgt gaa aag tgt ctg gat ggt tat atc gga gat      689
 Thr Thr Gly Glu His Cys Glu Lys Cys Leu Asp Gly Tyr Ile Gly Asp
 105                 110                 115                 120

 tcc atc agg gga gca ccc caa ttc tgc cag ccg tgc ccc tgt ccc ctg      737
 Ser Ile Arg Gly Ala Pro Gln Phe Cys Gln Pro Cys Pro Cys Pro Leu
                 125                 130                 135

 ccc cac ttg gcc aat ttt gca gaa tcc tgc tat agg aaa aat gga gct      785
 Pro His Leu Ala Asn Phe Ala Glu Ser Cys Tyr Arg Lys Asn Gly Ala
             140                 145                 150

 gtt cgg tgc att tgt aac gaa aat tat gct gga cct aac tgt gaa aga      833
 Val Arg Cys Ile Cys Asn Glu Asn Tyr Ala Gly Pro Asn Cys Glu Arg
         155                 160                 165

 tgt gct ccc ggt tac tat gga aac ccc tta ctc att gga agc acc tgt      881
 Cys Ala Pro Gly Tyr Tyr Gly Asn Pro Leu Leu Ile Gly Ser Thr Cys
     170                 175                 180

 aag aaa tgt gac tgc agt gga aat tca gat ccc aac ctg atc ttt gaa      929
 Lys Lys Cys Asp Cys Ser Gly Asn Ser Asp Pro Asn Leu Ile Phe Glu
 185                 190                 195                 200

 gat tgt gat gaa gtc act ggc cag tgt agg aat tgc tta cgc aac acc      977
 Asp Cys Asp Glu Val Thr Gly Gln Cys Arg Asn Cys Leu Arg Asn Thr
                 205                 210                 215

 acc gga ttc aag tgt gaa cgt tgc gct cct ggc tac tat ggg gac gcc     1025
 Thr Gly Phe Lys Cys Glu Arg Cys Ala Pro Gly Tyr Tyr Gly Asp Ala
             220                 225                 230

 agg ata gcc aag aac tgt gca gtg tgc aac tgc ggg gga ggc cca tgt     1073
 Arg Ile Ala Lys Asn Cys Ala Val Cys Asn Cys Gly Gly Gly Pro Cys
         235                 240                 245

 gac agt gta acc gga gaa tgc ttg gaa gaa ggt ttt gaa ccc cct aca     1121
 Asp Ser Val Thr Gly Glu Cys Leu Glu Glu Gly Phe Glu Pro Pro Thr
     250                 255                 260

 ggc atg gac tgc cca acc ata agc tgt gat aag tgc gtc tgg gac ctg     1169
 Gly Met Asp Cys Pro Thr Ile Ser Cys Asp Lys Cys Val Trp Asp Leu
 265                 270                 275                 280

 act gat gca ctg cgg tta gca gcg ctc tcc atc gag gaa ggc aaa tcc     1217
 Thr Asp Ala Leu Arg Leu Ala Ala Leu Ser Ile Glu Glu Gly Lys Ser
                 285                 290                 295

 ggg gtg ctg agc gta tcc tct ggg gcc gcc gct cat agg cac gtg aat     1265
 Gly Val Leu Ser Val Ser Ser Gly Ala Ala Ala His Arg His Val Asn
             300                 305                 310

 gaa atc aac gcc acc atc tac ctc ctc aaa aca aaa ttg tca gaa aga     1313
 Glu Ile Asn Ala Thr Ile Tyr Leu Leu Lys Thr Lys Leu Ser Glu Arg
         315                 320                 325

 gaa aac caa tac gcc cta aga aag ata caa atc aac aat gct gag aac     1361
 Glu Asn Gln Tyr Ala Leu Arg Lys Ile Gln Ile Asn Asn Ala Glu Asn
     330                 335                 340

 acg atg aaa agc ctt ctg tct gac gta gag gaa tta gtt gaa aag gaa     1409
 Thr Met Lys Ser Leu Leu Ser Asp Val Glu Glu Leu Val Glu Lys Glu
 345                 350                 355                 360

 aat caa gcc tcc aga aaa gga caa ctt gtt cag aag gaa agc atg gac     1457
 Asn Gln Ala Ser Arg Lys Gly Gln Leu Val Gln Lys Glu Ser Met Asp
                 365                 370                 375

 acc att aac cac gca agt cag ctg gta gag caa gcc cat gat atg agg     1505
 Thr Ile Asn His Ala Ser Gln Leu Val Glu Gln Ala His Asp Met Arg
             380                 385                 390

 gat aaa atc caa gag atc aac aac aag atg ctc tat tat ggg gaa gag     1553
 Asp Lys Ile Gln Glu Ile Asn Asn Lys Met Leu Tyr Tyr Gly Glu Glu
         395                 400                 405

 cat gaa ctt agc ccc aag gaa atc tct gag aag ctg gtg ttg gcc cag     1601
 His Glu Leu Ser Pro Lys Glu Ile Ser Glu Lys Leu Val Leu Ala Gln
     410                 415                 420

 aag atg ctt gaa gag att aga agc cgt caa cca ttt ttc acc caa cgg     1649
 Lys Met Leu Glu Glu Ile Arg Ser Arg Gln Pro Phe Phe Thr Gln Arg
 425                 430                 435                 440

 gag ctc gtg gat gag gag gca gat gag gct tac gaa cta ctg agc cag     1697
 Glu Leu Val Asp Glu Glu Ala Asp Glu Ala Tyr Glu Leu Leu Ser Gln
                 445                 450                 455

 gct gag agc tgg cag cgg ctg cac aat gag acc cgc act ctg ttt cct     1745
 Ala Glu Ser Trp Gln Arg Leu His Asn Glu Thr Arg Thr Leu Phe Pro
             460                 465                 470

 gtc gtc ctg gag cag ctg gat gac tac aat gct aag ttg tca gat ctc     1793
 Val Val Leu Glu Gln Leu Asp Asp Tyr Asn Ala Lys Leu Ser Asp Leu
         475                 480                 485

 cag gaa gca ctt gac cag gcc ctt aac cat gtc agg gat gcc gaa gac     1841
 Gln Glu Ala Leu Asp Gln Ala Leu Asn His Val Arg Asp Ala Glu Asp
     490                 495                 500

 atg aac agg gcc aca gca gcc agg cag cgg gac cat gag aaa caa cag     1889
 Met Asn Arg Ala Thr Ala Ala Arg Gln Arg Asp His Glu Lys Gln Gln
 505                 510                 515                 520

 gaa aga gtg agg gaa caa atg gaa gtg gtg aac atg tct ctg agc aca     1937
 Glu Arg Val Arg Glu Gln Met Glu Val Val Asn Met Ser Leu Ser Thr
                 525                 530                 535

 tct gcg gac tct ctg aca aca cct cgt cta act ctt tca gaa ctt gat     1985
 Ser Ala Asp Ser Leu Thr Thr Pro Arg Leu Thr Leu Ser Glu Leu Asp
             540                 545                 550

 gat ata ata aag aat gcg tca ggg att tat gca gaa ata gat gga gcc     2033
 Asp Ile Ile Lys Asn Ala Ser Gly Ile Tyr Ala Glu Ile Asp Gly Ala
         555                 560                 565

 aaa agt gaa cta caa gta aaa cta tct aac cta agt aac ctc agc cat     2081
 Lys Ser Glu Leu Gln Val Lys Leu Ser Asn Leu Ser Asn Leu Ser His
     570                 575                 580

 gat tta gtc caa gaa gct att gac cat gca cag gac ctt caa caa gaa     2129
 Asp Leu Val Gln Glu Ala Ile Asp His Ala Gln Asp Leu Gln Gln Glu
 585                 590                 595                 600

 gct aat gaa ttg agc agg aag ttg cac agt tca gat atg aac ggg ctg     2177
 Ala Asn Glu Leu Ser Arg Lys Leu His Ser Ser Asp Met Asn Gly Leu
                 605                 610                 615

 gta cag aag gct ttg gat gca tca aat gtc tat gaa aat att gtt aat     2225
 Val Gln Lys Ala Leu Asp Ala Ser Asn Val Tyr Glu Asn Ile Val Asn
             620                 625                 630

 tat gtt agt gaa gcc aat gaa aca gca gaa ttt gct ttg aac acc act     2273
 Tyr Val Ser Glu Ala Asn Glu Thr Ala Glu Phe Ala Leu Asn Thr Thr
         635                 640                 645

 gac cga att tat gat gcg gtg agt ggg att gat act caa atc att tac     2321
 Asp Arg Ile Tyr Asp Ala Val Ser Gly Ile Asp Thr Gln Ile Ile Tyr
     650                 655                 660

 cat aaa gat gaa agt gag aac ctc ctc aat caa gcc aga gaa ctg caa     2369
 His Lys Asp Glu Ser Glu Asn Leu Leu Asn Gln Ala Arg Glu Leu Gln
 665                 670                 675                 680

 gca aag gca gag tct agc agt gat gaa gca gtg gct gac act agc agg     2417
 Ala Lys Ala Glu Ser Ser Ser Asp Glu Ala Val Ala Asp Thr Ser Arg
                 685                 690                 695

 cgt gtg ggt gga gcc cta gca agg aaa agt gcc ctt aaa acc aga ctc     2465
 Arg Val Gly Gly Ala Leu Ala Arg Lys Ser Ala Leu Lys Thr Arg Leu
             700                 705                 710

 agt gat gcc gtt aag caa cta caa gca gca gag aga ggg gat gcc cag     2513
 Ser Asp Ala Val Lys Gln Leu Gln Ala Ala Glu Arg Gly Asp Ala Gln
         715                 720                 725

 cag cgc ctg ggg cag tct aga ctg atc acc gag gaa gcc aac agg acg     2561
 Gln Arg Leu Gly Gln Ser Arg Leu Ile Thr Glu Glu Ala Asn Arg Thr
     730                 735                 740

 acg atg gag gtg cag cag gcc act gcc ccc atg gcc aac aat cta acc     2609
 Thr Met Glu Val Gln Gln Ala Thr Ala Pro Met Ala Asn Asn Leu Thr
 745                 750                 755                 760

 aac tgg tca cag aat ctt caa cat ttt gac tct tct gct tac aac act     2657
 Asn Trp Ser Gln Asn Leu Gln His Phe Asp Ser Ser Ala Tyr Asn Thr
                 765                 770                 775

 gca gtg aac tct gct agg gat gca gta aga aat ctg acc gag gtt gtc     2705
 Ala Val Asn Ser Ala Arg Asp Ala Val Arg Asn Leu Thr Glu Val Val
             780                 785                 790

 cct cag ctc ctg gat cag ctt cgt acg gtt gag cag aag cga cct gca     2753
 Pro Gln Leu Leu Asp Gln Leu Arg Thr Val Glu Gln Lys Arg Pro Ala
         795                 800                 805

 agc aac gtt tct gcc agc atc cag agg atc cga gag ctc att gct cag     2801
 Ser Asn Val Ser Ala Ser Ile Gln Arg Ile Arg Glu Leu Ile Ala Gln
     810                 815                 820

 acc aga agt gtt gcc agc aag atc caa gtc tcc atg atg ttt gat ggc     2849
 Thr Arg Ser Val Ala Ser Lys Ile Gln Val Ser Met Met Phe Asp Gly
 825                 830                 835                 840

 cag tca gct gtg gaa gtg cac tcg aga acc agt atg gat gac tta aag     2897
 Gln Ser Ala Val Glu Val His Ser Arg Thr Ser Met Asp Asp Leu Lys
                 845                 850                 855

 gcc ttc acg tct ctg agc ctg tac atg aaa ccc cct gtg aag cgg ccg     2945
 Ala Phe Thr Ser Leu Ser Leu Tyr Met Lys Pro Pro Val Lys Arg Pro
             860                 865                 870

 gaa ctg acc gag act gca gat cag ttt atc ctg tac ctc gga agc aaa     2993
 Glu Leu Thr Glu Thr Ala Asp Gln Phe Ile Leu Tyr Leu Gly Ser Lys
         875                 880                 885

 aac gcc aaa aaa gag tat atg ggt ctt gca atc aaa aat gat aat ctg     3041
 Asn Ala Lys Lys Glu Tyr Met Gly Leu Ala Ile Lys Asn Asp Asn Leu
     890                 895                 900

 gta tac gtc tat aat ttg gga act aaa gat gtg gag att ccc ctg gac     3089
 Val Tyr Val Tyr Asn Leu Gly Thr Lys Asp Val Glu Ile Pro Leu Asp
 905                 910                 915                 920

 tcc aag ccc gtc agt tcc tgg cct gct tac ttc agc att gtc aag att     3137
 Ser Lys Pro Val Ser Ser Trp Pro Ala Tyr Phe Ser Ile Val Lys Ile
                 925                 930                 935

 gaa agg gtg gga aaa cat gga aag gtg ttt tta aca gtc ccg agt cta     3185
 Glu Arg Val Gly Lys His Gly Lys Val Phe Leu Thr Val Pro Ser Leu
             940                 945                 950

 agt agc aca gca gag gaa aag ttc att aaa aag ggg gaa ttt tcg gga     3233
 Ser Ser Thr Ala Glu Glu Lys Phe Ile Lys Lys Gly Glu Phe Ser Gly
         955                 960                 965

 gat gac tct ctg ctg gac ctg gac cct gag gac aca gtg ttt tat gtt     3281
 Asp Asp Ser Leu Leu Asp Leu Asp Pro Glu Asp Thr Val Phe Tyr Val
     970                 975                 980

 ggt gga gtg cct tcc aac ttc aag ctc cct acc agc tta aac ctg cct     3329
 Gly Gly Val Pro Ser Asn Phe Lys Leu Pro Thr Ser Leu Asn Leu Pro
 985                 990                 995                1000

 ggc ttt gtt ggc tgc ctg gaa ctg gcc act ttg aat aat gat gtg atc     3377
 Gly Phe Val Gly Cys Leu Glu Leu Ala Thr Leu Asn Asn Asp Val Ile
                1005                1010                1015

 agc ttg tac aac ttt aag cac atc tat aat atg gac ccc tcc aca tca     3425
 Ser Leu Tyr Asn Phe Lys His Ile Tyr Asn Met Asp Pro Ser Thr Ser
            1020                1025                1030

 gtg cca tgt gcc cga gat aag ctg gcc ttc act cag agt cgg gct gcc     3473
 Val Pro Cys Ala Arg Asp Lys Leu Ala Phe Thr Gln Ser Arg Ala Ala
        1035                1040                1045

 agt tac ttc ttc gat ggc tcc ggt tat gcc gtg gtg aga gac atc aca     3521
 Ser Tyr Phe Phe Asp Gly Ser Gly Tyr Ala Val Val Arg Asp Ile Thr
    1050                1055                1060

 agg aga ggg aaa ttt ggt cag gtg act cgc ttt gac ata gaa gtt cga     3569
 Arg Arg Gly Lys Phe Gly Gln Val Thr Arg Phe Asp Ile Glu Val Arg
1065                1070                1075                1080

 aca cca gct gac aac ggc ctt att ctc ctg atg gtc aat gga agt atg     3617
 Thr Pro Ala Asp Asn Gly Leu Ile Leu Leu Met Val Asn Gly Ser Met
                1085                1090                1095

 ttt ttc aga ctg gaa atg cgc aat ggt tac cta cat gtg ttc tat gat     3665
 Phe Phe Arg Leu Glu Met Arg Asn Gly Tyr Leu His Val Phe Tyr Asp
            1100                1105                1110

 ttt gga ttc agc agt ggc cct gtg cat ctt gaa gat acg tta aag aaa     3713
 Phe Gly Phe Ser Ser Gly Pro Val His Leu Glu Asp Thr Leu Lys Lys
        1115                1120                1125

 gct caa att aat gat gca aaa tac cat gag atc tca atc att tac cac     3761
 Ala Gln Ile Asn Asp Ala Lys Tyr His Glu Ile Ser Ile Ile Tyr His
    1130                1135                1140

 aat gat aag aaa atg atc ttg gta gtt gac aga agg cat gtc aag agc     3809
 Asn Asp Lys Lys Met Ile Leu Val Val Asp Arg Arg His Val Lys Ser
1145                1150                1155                1160

 atg gat aat gaa aag atg aaa ata cct ttt aca gat ata tac att gga     3857
 Met Asp Asn Glu Lys Met Lys Ile Pro Phe Thr Asp Ile Tyr Ile Gly
                1165                1170                1175

 gga gct cct cca gaa atc tta caa tcc agg gcc ctc aga gca cac ctt     3905
 Gly Ala Pro Pro Glu Ile Leu Gln Ser Arg Ala Leu Arg Ala His Leu
            1180                1185                1190

 ccc cta gat atc aac ttc aga gga tgc atg aag ggc ttc cag ttc caa     3953
 Pro Leu Asp Ile Asn Phe Arg Gly Cys Met Lys Gly Phe Gln Phe Gln
        1195                1200                1205

 aag aag gac ttc aat tta ctg gag cag aca gaa acc ctg gga gtt ggt     4001
 Lys Lys Asp Phe Asn Leu Leu Glu Gln Thr Glu Thr Leu Gly Val Gly
    1210                1215                1220

 tat gga tgc cca gaa gac tca ctt ata tct cgc aga gca tat ttc aat     4049
 Tyr Gly Cys Pro Glu Asp Ser Leu Ile Ser Arg Arg Ala Tyr Phe Asn
1225                1230                1235                1240

 gga cag agc ttc att gct tca att cag aaa ata tct ttc ttt gat ggc     4097
 Gly Gln Ser Phe Ile Ala Ser Ile Gln Lys Ile Ser Phe Phe Asp Gly
                1245                1250                1255

 ttt gaa gga ggt ttt aat ttc cga aca tta caa cca aat ggg tta cta     4145
 Phe Glu Gly Gly Phe Asn Phe Arg Thr Leu Gln Pro Asn Gly Leu Leu
            1260                1265                1270

 ttc tat tat gct tca ggg tca gac gtg ttc tcc atc tca ctg gat aat     4193
 Phe Tyr Tyr Ala Ser Gly Ser Asp Val Phe Ser Ile Ser Leu Asp Asn
        1275                1280                1285

 ggt act gtc atc atg gat gta aag gga atc aaa gtt cag tca gta gat     4241
 Gly Thr Val Ile Met Asp Val Lys Gly Ile Lys Val Gln Ser Val Asp
    1290                1295                1300

 aag cag tac aat gat ggg ctg tcc cac ttc gtc att agc tct gtc tca     4289
 Lys Gln Tyr Asn Asp Gly Leu Ser His Phe Val Ile Ser Ser Val Ser
1305                1310                1315                1320

 ccc aca aga tat gaa ctg ata gta gat aaa agc aga gtt ggg agt aag     4337
 Pro Thr Arg Tyr Glu Leu Ile Val Asp Lys Ser Arg Val Gly Ser Lys
                1325                1330                1335

 aat cct acc aaa ggg aaa ata gaa cag aca caa gca agt gaa aag aag     4385
 Asn Pro Thr Lys Gly Lys Ile Glu Gln Thr Gln Ala Ser Glu Lys Lys
            1340                1345                1350

 ttt tac ttc ggt ggc tca cca atc agt gct cag tat gct aat ttc act     4433
 Phe Tyr Phe Gly Gly Ser Pro Ile Ser Ala Gln Tyr Ala Asn Phe Thr
        1355                1360                1365

 ggc tgc ata agt aat gcc tac ttt acc agg gtg gat aga gat gtg gag     4481
 Gly Cys Ile Ser Asn Ala Tyr Phe Thr Arg Val Asp Arg Asp Val Glu
    1370                1375                1380

 gtt gaa gat ttc caa cgg tat act gaa aag gtc cac act tct ctt tat     4529
 Val Glu Asp Phe Gln Arg Tyr Thr Glu Lys Val His Thr Ser Leu Tyr
1385                1390                1395                1400

 gag tgt ccc att gag tct tca cca ttg ttt ctc ctc cat aaa aaa gga     4577
 Glu Cys Pro Ile Glu Ser Ser Pro Leu Phe Leu Leu His Lys Lys Gly
                1405                1410                1415

 aaa aat tta tcc aag cct aaa gca agt cag aat aaa aag gga ggg aaa     4625
 Lys Asn Leu Ser Lys Pro Lys Ala Ser Gln Asn Lys Lys Gly Gly Lys
            1420                1425                1430

 agt aaa gat gca cct tca tgg gat cct gtt gct ctg aaa ctc cca gag     4673
 Ser Lys Asp Ala Pro Ser Trp Asp Pro Val Ala Leu Lys Leu Pro Glu
        1435                1440                1445

 cgg aat act cca aga aac tct cat tgc cac ctt tcc aac agc cct aga     4721
 Arg Asn Thr Pro Arg Asn Ser His Cys His Leu Ser Asn Ser Pro Arg
    1450                1455                1460

 gca ata gag cac gcc tat caa tat gga gga aca gcc aac agc cgc caa     4769
 Ala Ile Glu His Ala Tyr Gln Tyr Gly Gly Thr Ala Asn Ser Arg Gln
1465                1470                1475                1480

 gag ttt gaa cac tta aaa gga gat ttt ggt gcc aaa tct cag ttt tcc     4817
 Glu Phe Glu His Leu Lys Gly Asp Phe Gly Ala Lys Ser Gln Phe Ser
                1485                1490                1495

 att cgt ctg aga act cgt tcc tcc cat ggc atg atc ttc tat gtc tca     4865
 Ile Arg Leu Arg Thr Arg Ser Ser His Gly Met Ile Phe Tyr Val Ser
            1500                1505                1510

 gat caa gaa gag aat gac ttc atg act cta ttt ttg gcc cat ggc cgc     4913
 Asp Gln Glu Glu Asn Asp Phe Met Thr Leu Phe Leu Ala His Gly Arg
        1515                1520                1525

 ttg gtt tac atg ttt aat gtt ggt cac aaa aaa ctg aag att aga agc     4961
 Leu Val Tyr Met Phe Asn Val Gly His Lys Lys Leu Lys Ile Arg Ser
    1530                1535                1540

 cag gag aaa tac aat gat ggc ctg tgg cat gat gtg ata ttt att cga     5009
 Gln Glu Lys Tyr Asn Asp Gly Leu Trp His Asp Val Ile Phe Ile Arg
1545                1550                1555                1560

 gaa agg agc agt ggc cga ctg gta att gat ggt ctc cga gtc cta gaa     5057
 Glu Arg Ser Ser Gly Arg Leu Val Ile Asp Gly Leu Arg Val Leu Glu
                1565                1570                1575

 gaa agt ctt cct cct act gaa gct acc tgg aaa atc aag ggt ccc att     5105
 Glu Ser Leu Pro Pro Thr Glu Ala Thr Trp Lys Ile Lys Gly Pro Ile
            1580                1585                1590

 tat ttg gga ggt gtg gct cct gga aag gct gtg aaa aat gtt cag att     5153
 Tyr Leu Gly Gly Val Ala Pro Gly Lys Ala Val Lys Asn Val Gln Ile
        1595                1600                1605

 aac tcc atc tac agt ttt agt ggc tgt ctc agc aat ctc cag ctc aat     5201
 Asn Ser Ile Tyr Ser Phe Ser Gly Cys Leu Ser Asn Leu Gln Leu Asn
    1610                1615                1620

 ggg gcc tcc atc acc tct gct tct cag aca ttc agt gtg acc cct tgc     5249
 Gly Ala Ser Ile Thr Ser Ala Ser Gln Thr Phe Ser Val Thr Pro Cys
1625                1630                1635                1640

 ttt gaa ggc ccc atg gaa aca gga act tac ttt tca aca gaa gga gga     5297
 Phe Glu Gly Pro Met Glu Thr Gly Thr Tyr Phe Ser Thr Glu Gly Gly
                1645                1650                1655

 tac gtg gtt cta gat gaa tct ttc aat att gga ttg aag ttt gaa att     5345
 Tyr Val Val Leu Asp Glu Ser Phe Asn Ile Gly Leu Lys Phe Glu Ile
            1660                1665                1670

 gca ttt gaa gtc cgt ccc aga agc agt tcc gga acc ctg gtc cac ggc     5393
 Ala Phe Glu Val Arg Pro Arg Ser Ser Ser Gly Thr Leu Val His Gly
        1675                1680                1685

 cac agt gtc aat ggg gag tac cta aat gtt cac atg aaa aat gga cag     5441
 His Ser Val Asn Gly Glu Tyr Leu Asn Val His Met Lys Asn Gly Gln
    1690                1695                1700

 gtc ata gtg aaa gtc aat aat ggc atc aga gat ttt tcc acc tca gta     5489
 Val Ile Val Lys Val Asn Asn Gly Ile Arg Asp Phe Ser Thr Ser Val
1705                1710                1715                1720

 aca ccc aag cag agt ctc tgt gat ggc aga tgg cac aga att aca gtt     5537
 Thr Pro Lys Gln Ser Leu Cys Asp Gly Arg Trp His Arg Ile Thr Val
                1725                1730                1735

 att aga gat tct aat gtg gtt cag ttg gat gtg gac tct gaa gtg aac     5585
 Ile Arg Asp Ser Asn Val Val Gln Leu Asp Val Asp Ser Glu Val Asn
            1740                1745                1750

 cat gtg gtt gga ccc ctg aat cca aaa cca att gat cac agg gag cct     5633
 His Val Val Gly Pro Leu Asn Pro Lys Pro Ile Asp His Arg Glu Pro
        1755                1760                1765

 gtg ttt gtt gga ggt gtt cca gaa tct cta ctg aca cca cgc ttg gcc     5681
 Val Phe Val Gly Gly Val Pro Glu Ser Leu Leu Thr Pro Arg Leu Ala
    1770                1775                1780

 ccc agc aaa ccc ttc aca ggc tgc ata cgc cac ttt gtg att gat gga     5729
 Pro Ser Lys Pro Phe Thr Gly Cys Ile Arg His Phe Val Ile Asp Gly
1785                1790                1795                1800

 cac cca gtg agc ttc agt aaa gca gcc ctg gtc agc ggc gcc gta agc     5777
 His Pro Val Ser Phe Ser Lys Ala Ala Leu Val Ser Gly Ala Val Ser
                1805                1810                1815

 atc aac tcc tgt cca gca gcc tga catgacagag cacagctgcc caaatacaaa    5831
 Ile Asn Ser Cys Pro Ala Ala 
            1820

 gttctttaga gcactgaaag aaacacaaag ccagccagga ggaacagtaa ctcttccttc   5891

 gggtggaagc tttcatcgag ttgaacagga cttaaacgaa tcatcaggga ccggatattt   5951

 cttatttctc atttggattc ttaaccttga atccaaagtg tctgcaatgg acaacaattg   6011

 aaggagtggc aaacttactt gtattgagag cacacgcaat tcctactggt gaaattactg   6071

 tttctgtttc taataaaata gaagggattc caaataaaca cttgcacaca tttttgaagt   6131

 gcggctagat tctcagattc acctttcttc cagggaagat aactttcaat ctatataaaa   6191

 atctctgtcc taaaactacc tttctttatt ttgaagagac ttactaactt acatataatc   6251

 taaattagat gatagatttg tttttagccc ttttgtttgg tctatcagta taagaagaat   6311

 attttaggtt tatagctgaa gttatcaagg tttaataaag taaatttcta acagaatact   6371

 agaaaaatgc agtataattt aattttttct aaataagaaa cacaggaaat caactacttt   6431

 ttccccttcc ttatctcctt aaaagaaaaa taaaattgta catgagaaaa a            6482




      <210> 213
      <211> 1400
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (312)..(1295)

      <400> 213
 cacgaggggc tttacatcct gtctttgaag gagacaatgt cattctgaga tgtcagggga     60

 aagacaacaa aaacactcat caaaaggttt actacaagga tggaaaacag cttcctaata    120

 gttataattt agagaagatc acagtgaatt cagtctccag ggataatagc aaatatcatt    180

 gtactgctta taggaagttt tacatacttg acattgaagt aacttcaaaa cccctaaata    240

 tccaagttca agagctgttt ctacatcctg tgctgagagc cagctcttcc acgcccatag    300

 aggggagtcc c atg acc ctg acc tgt gag acc cag ctc tct cca cag agg     350
              Met Thr Leu Thr Cys Glu Thr Gln Leu Ser Pro Gln Arg
                1               5                  10

 cca gat gtc cag ctg caa ttc tcc ctc ttc aga gat agc cag acc ctc      398
 Pro Asp Val Gln Leu Gln Phe Ser Leu Phe Arg Asp Ser Gln Thr Leu
      15                  20                  25

 gga ttg ggc tgg agc agg tcc ccc aga ctc cag atc cct gcc atg tgg      446
 Gly Leu Gly Trp Ser Arg Ser Pro Arg Leu Gln Ile Pro Ala Met Trp
  30                  35                  40                  45

 act gaa gac tca ggg tct tac tgg tgt gag gtg gag aca gtg act cac      494
 Thr Glu Asp Ser Gly Ser Tyr Trp Cys Glu Val Glu Thr Val Thr His
                  50                  55                  60

 agc atc aaa aaa agg agc ctg aga tct cag ata cgt gta cag aga gtc      542
 Ser Ile Lys Lys Arg Ser Leu Arg Ser Gln Ile Arg Val Gln Arg Val
              65                  70                  75

 cct gtg tct aat gtg aat cta gag atc cgg ccc acc gga ggg cag ctg      590
 Pro Val Ser Asn Val Asn Leu Glu Ile Arg Pro Thr Gly Gly Gln Leu
          80                  85                  90

 att gaa gga gaa aat atg gtc ctt att tgc tca gta gcc cag ggt tca      638
 Ile Glu Gly Glu Asn Met Val Leu Ile Cys Ser Val Ala Gln Gly Ser
      95                 100                 105

 ggg act gtc aca ttc tcc tgg cac aaa gaa gga aga gta aga agc ctg      686
 Gly Thr Val Thr Phe Ser Trp His Lys Glu Gly Arg Val Arg Ser Leu
 110                 115                 120                 125

 ggt aga aag acc cag cgt tcc ctg ttg gca gag ctg cat gtt ctc acc      734
 Gly Arg Lys Thr Gln Arg Ser Leu Leu Ala Glu Leu His Val Leu Thr
                 130                 135                 140

 gtg aag gag agt gat gca ggg aga tac tac tgt gca gct gat aac gtt      782
 Val Lys Glu Ser Asp Ala Gly Arg Tyr Tyr Cys Ala Ala Asp Asn Val
             145                 150                 155

 cac agc ccc atc ctc agc acg tgg att cga gtc acc gtg aga att ccg      830
 His Ser Pro Ile Leu Ser Thr Trp Ile Arg Val Thr Val Arg Ile Pro
         160                 165                 170

 gta tct cac cct gtc ctc acc ttc agg gct ccc agg gcc cac act gtg      878
 Val Ser His Pro Val Leu Thr Phe Arg Ala Pro Arg Ala His Thr Val
     175                 180                 185

 gtg ggg gac ctg ctg gag ctt cac tgt gag tcc ctg aga ggc tct ccc      926
 Val Gly Asp Leu Leu Glu Leu His Cys Glu Ser Leu Arg Gly Ser Pro
 190                 195                 200                 205

 ccg atc ctg tac cga ttt tat cat gag gat gtc acc ctg ggg aac agc      974
 Pro Ile Leu Tyr Arg Phe Tyr His Glu Asp Val Thr Leu Gly Asn Ser
                 210                 215                 220

 tca gcc ccc tct gga gga gga gcc tcc ttc aac ctc tct ctg act gca     1022
 Ser Ala Pro Ser Gly Gly Gly Ala Ser Phe Asn Leu Ser Leu Thr Ala
             225                 230                 235

 gaa cat tct gga aac tac tcc tgt gat gca gac aat ggc ctg ggg gcc     1070
 Glu His Ser Gly Asn Tyr Ser Cys Asp Ala Asp Asn Gly Leu Gly Ala
         240                 245                 250

 cag cac agt cat gga gtg agt ctc agg gtc aca gtt ccg gtg tct cgc     1118
 Gln His Ser His Gly Val Ser Leu Arg Val Thr Val Pro Val Ser Arg
     255                 260                 265

 ccc atc ctc acc ctc agg gct ccc agg gcc cag gct gtg gtg ggg gac     1166
 Pro Ile Leu Thr Leu Arg Ala Pro Arg Ala Gln Ala Val Val Gly Asp
 270                 275                 280                 285

 ctg ctg gag ctt cac tgt gag gcc ccg aga ggc tct ccc cca atc ctg     1214
 Leu Leu Glu Leu His Cys Glu Ala Pro Arg Gly Ser Pro Pro Ile Leu
                 290                 295                 300

 tac tgg ttt tat cat gag gat gtc acc ctg ggg agc agc tcg gcc cct     1262
 Tyr Trp Phe Tyr His Glu Asp Val Thr Leu Gly Ser Ser Ser Ala Pro
             305                 310                 315

 ctg gag gag aag ctt ctt tca acc tct ctc tga ctgcagaa cattctggaa     1313
 Leu Glu Glu Lys Leu Leu Ser Thr Ser Leu 
         320                 325

 actactcatg tgaggccaac aatggcctag tggccagcac agtgacacaa tatcactcag   1373

 tgttatagtt cagtatctcg tccatct                                       1400




      <210> 214
      <211> 2560
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (144)..(2501)

      <400> 214
 cgcggccgcg tcgactttaa gattaaattc atgtattgaa aatattgttc agaccccatg     60

 tgacataact ggagccagtg cagtgccatg aagaactacg agattagcct ggatattaac    120

 ttgtcttcta gagaatagat ttc    atg ttc cat tct tct gca atg gtt aat     170
                              Met Phe His Ser Ser Ala Met Val Asn
                                1               5

 tca cac aga aaa cca atg ttt aac att cac aga gga ttt tac tgc tta      218
 Ser His Arg Lys Pro Met Phe Asn Ile His Arg Gly Phe Tyr Cys Leu
  10                  15                  20                  25

 aca gcc atc ttg ccc caa ata tgc att tgt tct cag ttc tca gtg cca      266
 Thr Ala Ile Leu Pro Gln Ile Cys Ile Cys Ser Gln Phe Ser Val Pro
                  30                  35                  40

 tct agt tat cac ttc act gag gat cct ggg gct ttc cca gta gcc act      314
 Ser Ser Tyr His Phe Thr Glu Asp Pro Gly Ala Phe Pro Val Ala Thr
              45                  50                  55

 aat ggg gaa cga ttt cct tgg cag gag cta agg ctc ccc agt gtg gtc      362
 Asn Gly Glu Arg Phe Pro Trp Gln Glu Leu Arg Leu Pro Ser Val Val
          60                  65                  70

 att cct ctc cat tat gac ctc ttt gtc cac ccc aat ctc acc tct ctg      410
 Ile Pro Leu His Tyr Asp Leu Phe Val His Pro Asn Leu Thr Ser Leu
      75                  80                  85

 gac ttt gtt gca tct gag aag atc gaa gtc ttg gtc agc aat gct acc      458
 Asp Phe Val Ala Ser Glu Lys Ile Glu Val Leu Val Ser Asn Ala Thr
  90                  95                 100                 105

 cag ttt atc atc ttg cac agc aaa gat ctt gaa atc acg aat gcc acc      506
 Gln Phe Ile Ile Leu His Ser Lys Asp Leu Glu Ile Thr Asn Ala Thr
                 110                 115                 120

 ctt cag tca gag gaa gat tca aga tac atg aaa cca gga aaa gaa ctg      554
 Leu Gln Ser Glu Glu Asp Ser Arg Tyr Met Lys Pro Gly Lys Glu Leu
             125                 130                 135

 aaa gtt ttg agt tac cct gct cat gaa caa att gca ctg ctg gtt cca      602
 Lys Val Leu Ser Tyr Pro Ala His Glu Gln Ile Ala Leu Leu Val Pro
         140                 145                 150

 gag aaa ctt acg cct cac ctg aaa tac tat gtg gct atg gac ttc caa      650
 Glu Lys Leu Thr Pro His Leu Lys Tyr Tyr Val Ala Met Asp Phe Gln
     155                 160                 165

 gcc aag tta ggt gat ggc ttt gaa ggg ttt tat aaa agc aca tac aga      698
 Ala Lys Leu Gly Asp Gly Phe Glu Gly Phe Tyr Lys Ser Thr Tyr Arg
 170                 175                 180                 185

 act ctt ggt ggt gaa aca aga att ctt gca gta aca gat ttt gag cca      746
 Thr Leu Gly Gly Glu Thr Arg Ile Leu Ala Val Thr Asp Phe Glu Pro
                 190                 195                 200

 acc cag gca cgc atg gct ttc cct tgc ttt gat gaa ccg ttg ttc aaa      794
 Thr Gln Ala Arg Met Ala Phe Pro Cys Phe Asp Glu Pro Leu Phe Lys
             205                 210                 215

 gcc aac ttt tca atc aag ata cga aga gag agc agg cat att gca cta      842
 Ala Asn Phe Ser Ile Lys Ile Arg Arg Glu Ser Arg His Ile Ala Leu
         220                 225                 230

 tcc aac atg cca aag gtt aag aca att gaa ctt gaa gga ggt ctt ttg      890
 Ser Asn Met Pro Lys Val Lys Thr Ile Glu Leu Glu Gly Gly Leu Leu
     235                 240                 245

 gaa gat cac ttt gaa act act gta aaa atg agt aca tac ctt gta gcc      938
 Glu Asp His Phe Glu Thr Thr Val Lys Met Ser Thr Tyr Leu Val Ala
 250                 255                 260                 265

 tac ata gtt tgt gat ttc cac tct ctg agt ggc ttc act tca tca ggg      986
 Tyr Ile Val Cys Asp Phe His Ser Leu Ser Gly Phe Thr Ser Ser Gly
                 270                 275                 280

 gtc aag gtg tcc atc tat gca tcc cca gac aaa cgg aat caa aca cat     1034
 Val Lys Val Ser Ile Tyr Ala Ser Pro Asp Lys Arg Asn Gln Thr His
             285                 290                 295

 tat gct ttg cag gca tca ctg aag cta ctt gat ttt tat gaa aag tac     1082
 Tyr Ala Leu Gln Ala Ser Leu Lys Leu Leu Asp Phe Tyr Glu Lys Tyr
         300                 305                 310

 ttt gat atc tac tat cca ctc tcc aaa ctg gat tta att gct att cct     1130
 Phe Asp Ile Tyr Tyr Pro Leu Ser Lys Leu Asp Leu Ile Ala Ile Pro
     315                 320                 325

 gac ttt gca cct gga gcc atg gaa aat tgg ggc ctc att aca tat agg     1178
 Asp Phe Ala Pro Gly Ala Met Glu Asn Trp Gly Leu Ile Thr Tyr Arg
 330                 335                 340                 345

 gag acg tca ctg ctt ttt gac ccc aag acc tct tct gct tcc gat aaa     1226
 Glu Thr Ser Leu Leu Phe Asp Pro Lys Thr Ser Ser Ala Ser Asp Lys
                 350                 355                 360

 ctg tgg gtc acc aga gtc ata gcc cat gaa ctg gcg cac cag tgg ttt     1274
 Leu Trp Val Thr Arg Val Ile Ala His Glu Leu Ala His Gln Trp Phe
             365                 370                 375

 ggc aac ctg gtc aca atg gaa tgg tgg aat gat att tgg ctt aag gag     1322
 Gly Asn Leu Val Thr Met Glu Trp Trp Asn Asp Ile Trp Leu Lys Glu
         380                 385                 390

 ggt ttt gca aaa tac atg gaa ctt atc gct gtt aat gct aca tat cca     1370
 Gly Phe Ala Lys Tyr Met Glu Leu Ile Ala Val Asn Ala Thr Tyr Pro
     395                 400                 405

 gag ctg caa ttt gat gac tat ttt ttg aat gtg tgt ttt gaa gta att     1418
 Glu Leu Gln Phe Asp Asp Tyr Phe Leu Asn Val Cys Phe Glu Val Ile
 410                 415                 420                 425

 aca aaa gat tca ttg aat tca tcc cgc cct atc tcc aaa cca gcg gaa     1466
 Thr Lys Asp Ser Leu Asn Ser Ser Arg Pro Ile Ser Lys Pro Ala Glu
                 430                 435                 440

 acc ccg act caa ata cag gaa atg ttt gat gaa gtt tcc tat aac aag     1514
 Thr Pro Thr Gln Ile Gln Glu Met Phe Asp Glu Val Ser Tyr Asn Lys
             445                 450                 455

 gga gct tgt att ttg aat atg ctc aag gat ttt ctg ggt gag gag aaa     1562
 Gly Ala Cys Ile Leu Asn Met Leu Lys Asp Phe Leu Gly Glu Glu Lys
         460                 465                 470

 ttc cag aaa gga ata att cag tac tta aag aag ttc agc tat aga aat     1610
 Phe Gln Lys Gly Ile Ile Gln Tyr Leu Lys Lys Phe Ser Tyr Arg Asn
     475                 480                 485

 gct aac aat gat gac ttg tgg agc agt ctg tca aat agt tgt tta gaa     1658
 Ala Asn Asn Asp Asp Leu Trp Ser Ser Leu Ser Asn Ser Cys Leu Glu
 490                 495                 500                 505

 agt gat ttt aca tct ggt gga gtt tgt cat tcg gat ccc aag atg aca     1706
 Ser Asp Phe Thr Ser Gly Gly Val Cys His Ser Asp Pro Lys Met Thr
                 510                 515                 520

 agt aac atg ctc gcc ttt ctg ggg gaa aat gca gag gtc aaa gag atg     1754
 Ser Asn Met Leu Ala Phe Leu Gly Glu Asn Ala Glu Val Lys Glu Met
             525                 530                 535

 atg act aca tgg act ctc cag aaa gga atc ccc ctg ctg gtg gtt aaa     1802
 Met Thr Thr Trp Thr Leu Gln Lys Gly Ile Pro Leu Leu Val Val Lys
         540                 545                 550

 caa gac ggg tgt tca ctc cga ctg caa cag gag cgc ttc ctc cag ggg     1850
 Gln Asp Gly Cys Ser Leu Arg Leu Gln Gln Glu Arg Phe Leu Gln Gly
     555                 560                 565

 gtt ttc cag gaa gac cct gaa tgg agg gcc ctg cag gag agg tac ctg     1898
 Val Phe Gln Glu Asp Pro Glu Trp Arg Ala Leu Gln Glu Arg Tyr Leu
 570                 575                 580                 585

 tgg cat atc cca ttg acc tac tcc acg agt tct tct aat gtg atc cac     1946
 Trp His Ile Pro Leu Thr Tyr Ser Thr Ser Ser Ser Asn Val Ile His
                 590                 595                 600

 aga cac att cta aaa tca aag aca gat act ctg gat cta cct gaa aag     1994
 Arg His Ile Leu Lys Ser Lys Thr Asp Thr Leu Asp Leu Pro Glu Lys
             605                 610                 615

 acc agt tgg gtg aaa ttt aat gtg gac tca aat ggt tac tac atc gtt     2042
 Thr Ser Trp Val Lys Phe Asn Val Asp Ser Asn Gly Tyr Tyr Ile Val
         620                 625                 630

 cac tat gag ggt cat gga tgg gac caa ctc att aca cag ctg aat cag     2090
 His Tyr Glu Gly His Gly Trp Asp Gln Leu Ile Thr Gln Leu Asn Gln
     635                 640                 645

 aac cac aca ctt ctc aga cct aag gac aga gta ggt ctg att cat gat     2138
 Asn His Thr Leu Leu Arg Pro Lys Asp Arg Val Gly Leu Ile His Asp
 650                 655                 660                 665

 gtg ttt cag cta gtt ggt gca ggg aga ctg acc cta gac aaa gct ctt     2186
 Val Phe Gln Leu Val Gly Ala Gly Arg Leu Thr Leu Asp Lys Ala Leu
                 670                 675                 680

 gac atg act tac tac ctc caa cat gaa aca agc agc ccc gca ctt ctc     2234
 Asp Met Thr Tyr Tyr Leu Gln His Glu Thr Ser Ser Pro Ala Leu Leu
             685                 690                 695

 gaa ggt ctg agt tac ttg gaa tcg ttt tac cac atg atg gac aga agg     2282
 Glu Gly Leu Ser Tyr Leu Glu Ser Phe Tyr His Met Met Asp Arg Arg
         700                 705                 710

 aat att tca gat atc tct gaa aac ctc aag cgt tac ctt ctt cag tat     2330
 Asn Ile Ser Asp Ile Ser Glu Asn Leu Lys Arg Tyr Leu Leu Gln Tyr
     715                 720                 725

 ttt aag cca gtg att gac agg caa agc tgg agt gac aag ggc tca gtc     2378
 Phe Lys Pro Val Ile Asp Arg Gln Ser Trp Ser Asp Lys Gly Ser Val
 730                 735                 740                 745

 tgg gac agg atg ctc cgc tcg gct ctc ttg aag ctg gcc tgt gac ctg     2426
 Trp Asp Arg Met Leu Arg Ser Ala Leu Leu Lys Leu Ala Cys Asp Leu
                 750                 755                 760

 aac cat gct cct tgc atc cag aaa gct gct gaa ctc ttc ttc cag tgg     2474
 Asn His Ala Pro Cys Ile Gln Lys Ala Ala Glu Leu Phe Phe Gln Trp
             765                 770                 775

 atg gaa tcc agt gga aaa tta aag tag atgta gacttctgtc ctaccctttg     2526
 Met Glu Ser Ser Gly Lys Leu Lys 
         780                 785

 ttcttttctt tttgaggaaa aagtcttgat ccaa                               2560




      <210> 215
      <211> 701
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (333)..(611)

      <400> 215
 atctgacact ctccccctcc ttctccaaca cttggttagg tggctcttct atgttctcct     60

 ataacacact acacttctcc cagcacagaa cttaccacac tgcacagtgg tctgtttgcc    120

 aatcagagaa gcaacacgcc agcatggcag ggaatccagg ctttgggggc ggacagttct    180

 gggtttgaaa atatccccac ctctcactag ctgtatgact atcagcaagt tactaaatct    240

 ctaggctttg aactcctcat ctgtaacacg ggctagaaac acctacctca catggttgct    300

 gcaaagacta aatcagacaa ggcaggaaga ac  atg gta caa gca cct aag aag     353
                                      Met Val Gln Ala Pro Lys Lys
                                        1               5

 cac tca gta agt ggt agt tat ttt tta tta ttt ttt gag acg agg tct      401
 His Ser Val Ser Gly Ser Tyr Phe Leu Leu Phe Phe Glu Thr Arg Ser
          10                  15                  20

 gtc acg cag gct gga gta cag cgg cat gat cat ggc tca ctg cag tct      449
 Val Thr Gln Ala Gly Val Gln Arg His Asp His Gly Ser Leu Gln Ser
      25                  30                  35

 caa cca ccc aga ctc aag cga tcc tcc cac ctc agc ctc cag agt agc      497
 Gln Pro Pro Arg Leu Lys Arg Ser Ser His Leu Ser Leu Gln Ser Ser
  40                  45                  50                  55

 tgg gac cac aga tgt gta cca tca cac tca gct aat ttt aaa att atg      545
 Trp Asp His Arg Cys Val Pro Ser His Ser Ala Asn Phe Lys Ile Met
                  60                  65                  70

 aat att tgt aga ggt gag gtc tca cta cgt tgc cca gga tgg tct cga      593
 Asn Ile Cys Arg Gly Glu Val Ser Leu Arg Cys Pro Gly Trp Ser Arg
              75                  80                  85

 gct cct gac ctc aag tga tctgcc caccttggcc tcccaaagtg ctggaattac      647
 Ala Pro Asp Leu Lys 
          90

 aggctgagcc accacacccg gcctattatt tccctattat aatggaacta agag          701




      <210> 216
      <211> 6222
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(4284)

      <400> 216
  atg ggt aag cca ctc agc aga cca gac tgt tta agg cgg aac ccc agc      48
  Met Gly Lys Pro Leu Ser Arg Pro Asp Cys Leu Arg Arg Asn Pro Ser
    1               5                  10                  15

 tgc ctg ggg aaa gga gag gag gag gat ggc tac ata gag gac tgc tat       96
 Cys Leu Gly Lys Gly Glu Glu Glu Asp Gly Tyr Ile Glu Asp Cys Tyr
              20                  25                  30

 gtt cca caa cgg tct ata tat gat acg atg agg ata aat gag caa att      144
 Val Pro Gln Arg Ser Ile Tyr Asp Thr Met Arg Ile Asn Glu Gln Ile
          35                  40                  45

 gac cag ggg tca aag ctt aac cag act tca aaa agc acc atg gaa aag      192
 Asp Gln Gly Ser Lys Leu Asn Gln Thr Ser Lys Ser Thr Met Glu Lys
      50                  55                  60

 atg gaa gga agt act ata tcc agc aat ggt aca tta gga gca gca tct      240
 Met Glu Gly Ser Thr Ile Ser Ser Asn Gly Thr Leu Gly Ala Ala Ser
  65                  70                  75                  80

 aat gtt ttt gaa tct aga gca cca gaa ggt aag aag ctg gat gag agg      288
 Asn Val Phe Glu Ser Arg Ala Pro Glu Gly Lys Lys Leu Asp Glu Arg
                  85                  90                  95

 ata ata ttt gat gca cta aag cta agc agt gat gtg cag aag tca gca      336
 Ile Ile Phe Asp Ala Leu Lys Leu Ser Ser Asp Val Gln Lys Ser Ala
             100                 105                 110

 cct gtg cca ccc aga agg cgg cca aat gca gaa cgc aaa gac aat gtt      384
 Pro Val Pro Pro Arg Arg Arg Pro Asn Ala Glu Arg Lys Asp Asn Val
         115                 120                 125

 aac agg aga tcg tgg aag tcc ttc atg cca ccc aac ttc cca gaa ttt      432
 Asn Arg Arg Ser Trp Lys Ser Phe Met Pro Pro Asn Phe Pro Glu Phe
     130                 135                 140

 gca gag agg ata gaa gct tct ctc agt gag gtt tca gaa gct ggt gct      480
 Ala Glu Arg Ile Glu Ala Ser Leu Ser Glu Val Ser Glu Ala Gly Ala
 145                 150                 155                 160

 tca aat cct tcc ttg caa gag aag aag gag tcc agt tct gca tta aca      528
 Ser Asn Pro Ser Leu Gln Glu Lys Lys Glu Ser Ser Ser Ala Leu Thr
                 165                 170                 175

 gaa agt tct ggt cat ttg gac cac agg gaa cct cag tca gag tca gta      576
 Glu Ser Ser Gly His Leu Asp His Arg Glu Pro Gln Ser Glu Ser Val
             180                 185                 190

 act ctg gaa cat gtg tcc aaa tcc ata ggt att cca gag gtg caa gat      624
 Thr Leu Glu His Val Ser Lys Ser Ile Gly Ile Pro Glu Val Gln Asp
         195                 200                 205

 ttt aaa aac tta agt gga gac tgc cag gac ttt aga ttt cag cag cac      672
 Phe Lys Asn Leu Ser Gly Asp Cys Gln Asp Phe Arg Phe Gln Gln His
     210                 215                 220

 agt gca aac cct cct cat gaa ttc cag cct gta gaa tca gaa gct gta      720
 Ser Ala Asn Pro Pro His Glu Phe Gln Pro Val Glu Ser Glu Ala Val
 225                 230                 235                 240

 gca aca agt ggt aac aca gat gta atg cag gaa tcc aga ttc tca agt      768
 Ala Thr Ser Gly Asn Thr Asp Val Met Gln Glu Ser Arg Phe Ser Ser
                 245                 250                 255

 gca acc tgg ccg agg gcc aca aaa agt tta gct aag gga ggc ttc agt      816
 Ala Thr Trp Pro Arg Ala Thr Lys Ser Leu Ala Lys Gly Gly Phe Ser
             260                 265                 270

 gag aag cag cac ccc ctt ggg gac aca gcc tgc act gtg gaa atg cca      864
 Glu Lys Gln His Pro Leu Gly Asp Thr Ala Cys Thr Val Glu Met Pro
         275                 280                 285

 cct ctc tcc cct tgc ctg agt gaa gag ctg tta gat cca gaa ttg cat      912
 Pro Leu Ser Pro Cys Leu Ser Glu Glu Leu Leu Asp Pro Glu Leu His
     290                 295                 300

 gtt ctc ata acc ccc agc ctg aga gag aaa aca gag tct gag cta aag      960
 Val Leu Ile Thr Pro Ser Leu Arg Glu Lys Thr Glu Ser Glu Leu Lys
 305                 310                 315                 320

 ttt gag gag gat gag cga tgg att atg atg gag gct gag gga gag tgg     1008
 Phe Glu Glu Asp Glu Arg Trp Ile Met Met Glu Ala Glu Gly Glu Trp
                 325                 330                 335

 gag gaa gag aaa ctg tca gac agg gaa aag act ttt ctg gtg gca gat     1056
 Glu Glu Glu Lys Leu Ser Asp Arg Glu Lys Thr Phe Leu Val Ala Asp
             340                 345                 350

 gag aag aac agc ctg gca gat att ttt gaa gaa aga gaa caa gca aac     1104
 Glu Lys Asn Ser Leu Ala Asp Ile Phe Glu Glu Arg Glu Gln Ala Asn
         355                 360                 365

 aca gca gtg gtg gag gat gga tcc gat tgc tta gct gct gtc ttg agg     1152
 Thr Ala Val Val Glu Asp Gly Ser Asp Cys Leu Ala Ala Val Leu Arg
     370                 375                 380

 act ttt ggc cac cta tct ctt ggt cag att tgt tgc cct gat gac cca     1200
 Thr Phe Gly His Leu Ser Leu Gly Gln Ile Cys Cys Pro Asp Asp Pro
 385                 390                 395                 400

 cag cca gcc aag gac cag ttg gct act gtt ccc aag gat ata ccc ctg     1248
 Gln Pro Ala Lys Asp Gln Leu Ala Thr Val Pro Lys Asp Ile Pro Leu
                 405                 410                 415

 gat tgc gat tgt gtt ctt aca ggt gag gat att ctc ggt gag gtg gca     1296
 Asp Cys Asp Cys Val Leu Thr Gly Glu Asp Ile Leu Gly Glu Val Ala
             420                 425                 430

 aac aga act gct cag ggg tta gag gga ctt gtt tca gat tca gca tgt     1344
 Asn Arg Thr Ala Gln Gly Leu Glu Gly Leu Val Ser Asp Ser Ala Cys
         435                 440                 445

 act gtg ggt act att gat gca gaa cag ctc tct gac aca gac tca gtg     1392
 Thr Val Gly Thr Ile Asp Ala Glu Gln Leu Ser Asp Thr Asp Ser Val
     450                 455                 460

 cag atg ttt ctt gaa ctt gaa aag gag tgt tta tgt gaa gaa gga gta     1440
 Gln Met Phe Leu Glu Leu Glu Lys Glu Cys Leu Cys Glu Glu Gly Val
 465                 470                 475                 480

 act cct cta gtt gag cta cag aat caa atc tct tct gaa ggg ctg gct     1488
 Thr Pro Leu Val Glu Leu Gln Asn Gln Ile Ser Ser Glu Gly Leu Ala
                 485                 490                 495

 gca tcc cag gat gca gaa aat tta ctc gta att agt cat ttt tca ggg     1536
 Ala Ser Gln Asp Ala Glu Asn Leu Leu Val Ile Ser His Phe Ser Gly
             500                 505                 510

 gct gcc tta gaa aag gaa cag cat tta ggc ctt tta cat gta agg gca     1584
 Ala Ala Leu Glu Lys Glu Gln His Leu Gly Leu Leu His Val Arg Ala
         515                 520                 525

 aaa gat tat gat act aga ttg gat tgt gga tat ttt aat acc ctg gat     1632
 Lys Asp Tyr Asp Thr Arg Leu Asp Cys Gly Tyr Phe Asn Thr Leu Asp
     530                 535                 540

 tct tct cag gtg cct aat gct gtg gaa ctt att gcc cac gtt gat atc     1680
 Ser Ser Gln Val Pro Asn Ala Val Glu Leu Ile Ala His Val Asp Ile
 545                 550                 555                 560

 atg aga gac act tcc act gtt agc aag gag gaa tgt gaa aaa gtg cct     1728
 Met Arg Asp Thr Ser Thr Val Ser Lys Glu Glu Cys Glu Lys Val Pro
                 565                 570                 575

 ttt agc ccc agg act gca gaa ttt aag tcc aga cag cca gct gat ctg     1776
 Phe Ser Pro Arg Thr Ala Glu Phe Lys Ser Arg Gln Pro Ala Asp Leu
             580                 585                 590

 gat tca ctg gaa aag ctg gac cca gga gga ctg ctg aac tct gat cac     1824
 Asp Ser Leu Glu Lys Leu Asp Pro Gly Gly Leu Leu Asn Ser Asp His
         595                 600                 605

 agg gtt tct cat gaa gaa aaa tta tca ggc ttc att gct tct gag ctg     1872
 Arg Val Ser His Glu Glu Lys Leu Ser Gly Phe Ile Ala Ser Glu Leu
     610                 615                 620

 gcc aaa gac aat ggc agt ttg tcc cag gga gac tgc agt caa act gag     1920
 Ala Lys Asp Asn Gly Ser Leu Ser Gln Gly Asp Cys Ser Gln Thr Glu
 625                 630                 635                 640

 ggg aat ggt gag gag tgc att gag agg gtc acc ttc agt ttt gct ttt     1968
 Gly Asn Gly Glu Glu Cys Ile Glu Arg Val Thr Phe Ser Phe Ala Phe
                 645                 650                 655

 aat cat gaa cta aca gat gtt acc tca gga cct gaa gta gag gtg tta     2016
 Asn His Glu Leu Thr Asp Val Thr Ser Gly Pro Glu Val Glu Val Leu
             660                 665                 670

 tat gaa tca aat tta cta aca gat gaa att cat ttg gaa agt ggg aat     2064
 Tyr Glu Ser Asn Leu Leu Thr Asp Glu Ile His Leu Glu Ser Gly Asn
         675                 680                 685

 gta act gtt aat caa gaa aat aac agt ctg aca tca atg gga aat gtg     2112
 Val Thr Val Asn Gln Glu Asn Asn Ser Leu Thr Ser Met Gly Asn Val
     690                 695                 700

 gtc act tgt gaa ttg tct gtg gag aaa gtt tgt gat gag gat ggt gag     2160
 Val Thr Cys Glu Leu Ser Val Glu Lys Val Cys Asp Glu Asp Gly Glu
 705                 710                 715                 720

 gca aaa gag ctg gat tat caa gcc aca ctt ttg gag gat caa gct cca     2208
 Ala Lys Glu Leu Asp Tyr Gln Ala Thr Leu Leu Glu Asp Gln Ala Pro
                 725                 730                 735

 gca cat ttc cac aga aac ttc cca gag cag gtc ttc cag gat ctc cag     2256
 Ala His Phe His Arg Asn Phe Pro Glu Gln Val Phe Gln Asp Leu Gln
             740                 745                 750

 agg aag tcc cca gag tca gag att ctg agt ctg cac ctg ctg gtt gaa     2304
 Arg Lys Ser Pro Glu Ser Glu Ile Leu Ser Leu His Leu Leu Val Glu
         755                 760                 765

 gaa ctg aga ctt aat cca gat gga gtg gaa act gtg aat gat aca aag     2352
 Glu Leu Arg Leu Asn Pro Asp Gly Val Glu Thr Val Asn Asp Thr Lys
     770                 775                 780

 cct gag ctg aat gtg gca tca tca gag gga ggg gag atg gaa agg aga     2400
 Pro Glu Leu Asn Val Ala Ser Ser Glu Gly Gly Glu Met Glu Arg Arg
 785                 790                 795                 800

 gat tca gat tca ttc cta aat att ttt cca gag aaa caa gtt acc aag     2448
 Asp Ser Asp Ser Phe Leu Asn Ile Phe Pro Glu Lys Gln Val Thr Lys
                 805                 810                 815

 gct ggt aat act gaa cca gtt tta gag gaa tgg ata ccc gtc ctc cag     2496
 Ala Gly Asn Thr Glu Pro Val Leu Glu Glu Trp Ile Pro Val Leu Gln
             820                 825                 830

 aga cct tcc cgg act gct gca gta ccc act gtc aaa gat gcc cta gat     2544
 Arg Pro Ser Arg Thr Ala Ala Val Pro Thr Val Lys Asp Ala Leu Asp
         835                 840                 845

 gct gca ctg ccc agc cca gag gag ggt acc tca att gct gca gtg cct     2592
 Ala Ala Leu Pro Ser Pro Glu Glu Gly Thr Ser Ile Ala Ala Val Pro
     850                 855                 860

 gcc cca gag gga act gct gta gtt gct gct tta gtg ccc ttt cca cat     2640
 Ala Pro Glu Gly Thr Ala Val Val Ala Ala Leu Val Pro Phe Pro His
 865                 870                 875                 880

 gag gac atc cta gtt gct tca ata gtc tcc tta gag gag gag gat gtc     2688
 Glu Asp Ile Leu Val Ala Ser Ile Val Ser Leu Glu Glu Glu Asp Val
                 885                 890                 895

 aca gct gct gca gta tca gcc cca gag agg gct act gtc cca gct gtt     2736
 Thr Ala Ala Ala Val Ser Ala Pro Glu Arg Ala Thr Val Pro Ala Val
             900                 905                 910

 aca gta tct gtc cct gaa ggg act gct gca gtt gct gca gtg tcc tcc     2784
 Thr Val Ser Val Pro Glu Gly Thr Ala Ala Val Ala Ala Val Ser Ser
         915                 920                 925

 cca gag gag act gct cca gct gtt gca gca gcc atc aca cag gag ggt     2832
 Pro Glu Glu Thr Ala Pro Ala Val Ala Ala Ala Ile Thr Gln Glu Gly
     930                 935                 940

 atg tca gct gtc gca ggg ttc tcc cca gag tgg gct gct tta gct att     2880
 Met Ser Ala Val Ala Gly Phe Ser Pro Glu Trp Ala Ala Leu Ala Ile
 945                 950                 955                 960

 aca gta ccc atc aca gag gag gat ggt aca cca gaa ggg cct gtc acc     2928
 Thr Val Pro Ile Thr Glu Glu Asp Gly Thr Pro Glu Gly Pro Val Thr
                 965                 970                 975

 cca gct acc aca gtg cat gct cca gag gag cct gat act gca gct gtc     2976
 Pro Ala Thr Thr Val His Ala Pro Glu Glu Pro Asp Thr Ala Ala Val
             980                 985                 990

 aga gtg tcc acc cca gag gag ccc gcc tcc cca gct gct gca gtg ccc     3024
 Arg Val Ser Thr Pro Glu Glu Pro Ala Ser Pro Ala Ala Ala Val Pro
         995                1000                1005

 acc cca gag gag ccc acc tcc cca gct gct gca gtg ccc acc cca gag     3072
 Thr Pro Glu Glu Pro Thr Ser Pro Ala Ala Ala Val Pro Thr Pro Glu
    1010                1015                1020

 gag ccc acc tcc cca gct gct gca gtg ccc ccc cca gag gag ccc acc     3120
 Glu Pro Thr Ser Pro Ala Ala Ala Val Pro Pro Pro Glu Glu Pro Thr
1025                1030                1035                1040

 tcc cca gct gct gca gtg ccc acc cca gag gag ccc acc tcc cca gct     3168
 Ser Pro Ala Ala Ala Val Pro Thr Pro Glu Glu Pro Thr Ser Pro Ala
                1045                1050                1055

 gct gca gtg ccc acc cca gag gag ccc acc tcc cca gct gct gca gtg     3216
 Ala Ala Val Pro Thr Pro Glu Glu Pro Thr Ser Pro Ala Ala Ala Val
            1060                1065                1070

 ccc acc cca gag gag ccc acc tcc cca gct gct gca gtg ccc acc cca     3264
 Pro Thr Pro Glu Glu Pro Thr Ser Pro Ala Ala Ala Val Pro Thr Pro
        1075                1080                1085

 gag gag ccc acc tcc cca gct gct gca gtg ccc acc cca gag gag ccc     3312
 Glu Glu Pro Thr Ser Pro Ala Ala Ala Val Pro Thr Pro Glu Glu Pro
    1090                1095                1100

 acc tcc cca gct gct gca gtg ccc acc cca gag gag ccc gcc tcc cca     3360
 Thr Ser Pro Ala Ala Ala Val Pro Thr Pro Glu Glu Pro Ala Ser Pro
1105                1110                1115                1120

 gct gct gca gtg ccc acc cca gag gag ccc gcc tcc cca gct gct gca     3408
 Ala Ala Ala Val Pro Thr Pro Glu Glu Pro Ala Ser Pro Ala Ala Ala
                1125                1130                1135

 gtg ccc acc cca gag gag cct gcc ttc cca gct cct gca gtg ccc acc     3456
 Val Pro Thr Pro Glu Glu Pro Ala Phe Pro Ala Pro Ala Val Pro Thr
            1140                1145                1150

 cca gag gaa tcc gcc tcc gca gct gtt gca gtg ccc acc ccc gag gaa     3504
 Pro Glu Glu Ser Ala Ser Ala Ala Val Ala Val Pro Thr Pro Glu Glu
        1155                1160                1165

 tct gcc tcc cca gct gct gca gtg ccc acc cca gca gaa tct gcc tcc     3552
 Ser Ala Ser Pro Ala Ala Ala Val Pro Thr Pro Ala Glu Ser Ala Ser
    1170                1175                1180

 ttt gca gct gtg gtg gcc acc ctg gag gaa ccc act tcc ccg gca gct     3600
 Phe Ala Ala Val Val Ala Thr Leu Glu Glu Pro Thr Ser Pro Ala Ala
1185                1190                1195                1200

 tca gtg ccc acc cct gca gct atg gtg gcc acc cta gag gaa ttc act     3648
 Ser Val Pro Thr Pro Ala Ala Met Val Ala Thr Leu Glu Glu Phe Thr
                1205                1210                1215

 tcc ccg gca gct tca gtg ccc acc tct gag gag cct gcc tcc cta gca     3696
 Ser Pro Ala Ala Ser Val Pro Thr Ser Glu Glu Pro Ala Ser Leu Ala
            1220                1225                1230

 gct gca gtg tcc aac cca gag gag ccc acc tcc cca gca gca gca gtg     3744
 Ala Ala Val Ser Asn Pro Glu Glu Pro Thr Ser Pro Ala Ala Ala Val
        1235                1240                1245

 ccc acc cta gag gaa ccc acc tcc tca gca gct gca gtg ctc acc cca     3792
 Pro Thr Leu Glu Glu Pro Thr Ser Ser Ala Ala Ala Val Leu Thr Pro
    1250                1255                1260

 gag gaa ctc agt tcc cca gca gct tca gtg ccc acc ccc gag gag cct     3840
 Glu Glu Leu Ser Ser Pro Ala Ala Ser Val Pro Thr Pro Glu Glu Pro
1265                1270                1275                1280

 gcc tcc cca gca gct gca gtg tcc aac cta gag gag ccc gcc tcc cca     3888
 Ala Ser Pro Ala Ala Ala Val Ser Asn Leu Glu Glu Pro Ala Ser Pro
                1285                1290                1295

 gca gca gca gtg ccc acc cca gag gtg gct gcc atc cct gct gct tca     3936
 Ala Ala Ala Val Pro Thr Pro Glu Val Ala Ala Ile Pro Ala Ala Ser
            1300                1305                1310

 gtg ccc acc cca gag gtg cct gcc atc cca gct gct gca gtg cct cct     3984
 Val Pro Thr Pro Glu Val Pro Ala Ile Pro Ala Ala Ala Val Pro Pro
        1315                1320                1325

 atg gag gaa gtt tcc ccc att ggt gtg ccc ttc ctg gga gtt tct gcc     4032
 Met Glu Glu Val Ser Pro Ile Gly Val Pro Phe Leu Gly Val Ser Ala
    1330                1335                1340

 cac act gac tca gtg cct att tca gaa gaa gga aca cct gtt cta gag     4080
 His Thr Asp Ser Val Pro Ile Ser Glu Glu Gly Thr Pro Val Leu Glu
1345                1350                1355                1360

 gag gct tcc tcc act gga atg tgg atc aag gag gac ctt gat tcc cta     4128
 Glu Ala Ser Ser Thr Gly Met Trp Ile Lys Glu Asp Leu Asp Ser Leu
                1365                1370                1375

 gta ttt ggc ata aaa gag gtg acc agc aca gtg cta cat ggg aaa gtg     4176
 Val Phe Gly Ile Lys Glu Val Thr Ser Thr Val Leu His Gly Lys Val
            1380                1385                1390

 cct ctg gct gca acc gct gga tta aat tca gat gag gta att gtc cat     4224
 Pro Leu Ala Ala Thr Ala Gly Leu Asn Ser Asp Glu Val Ile Val His
        1395                1400                1405

 ttt gat tct ggg aag ggt cta aag agt aaa gtg aga ttt gca ggg ctg     4272
 Phe Asp Ser Gly Lys Gly Leu Lys Ser Lys Val Arg Phe Ala Gly Leu
    1410                1415                1420

 acc tgg tgg tga tga gaaatggcac agatagttct tttgttcttt ttgggtctcc     4327
 Thr Trp Trp 
1425

 cgggcttata gtttgtagtc tttctgttca gtttttgggg aaaatatact ttaattttgt   4387

 ctggtgaaag actttataat ttcatgcttc gttttttatt cagataagcc aatcccacgg   4447

 aaaacaggga tataaacagt tgttgattta catttttaaa aagattatta gcaggaaagg   4507

 gtcattctgt ttttgaatta tacagtgagc atgttcttgc ctaaaccaag agacagttta   4567

 ttcattggtg gtgtcaacat ttaggtagag gccagagtgt gagctttgga atgagacctg   4627

 gggtgcttcc taaccactct gggaaaatta gttagctatt cttgagtttc ctgtttcttc   4687

 atttgttaag gcataactct gtgaggataa aatgagatac atttaaggta ccaagcgtat   4747

 aagattacca atcactggcc atatcctccc cattcttttc aaataggtat gttggttggt   4807

 tgaaagaatt taccaaagta gattggagag aagcaataaa gctaaatgat taagaacttt   4867

 taaatgcaaa tatgtgtttc tgaaaaccag agctaggcat aatgtttatg aaaaatagag   4927

 atattttagt catctttgtc aaactgcctt tgtgtcctta agcaagtcat tttcctttcc   4987

 aggacctcat ttcttcatta taaaacaaga aaattgggct aaatgtcctc ttgggtctct   5047

 cttggctcta agattctttt tatttttttt ttttagatgg agtctggctc tgtcagtcag   5107

 gctggagtgc tggagtgcag tggtgcggtc tcggctcact gcaggctccg cctcccgggt   5167

 tcacgccatt ctcctgcctc agcctcccga gtagctggga ctgcaggcgc ccgccactac   5227

 gcccggcaat tttttgtata tatatatata taattttttt tttttttttt tagtggagac   5287

 gggtttcact gtgttggcca ggatggtctc ggtctcctga cctcgtggtc tgcccgcctc   5347

 ggcctcccag agtgctggga ttgcaggcgt gagccaccgc gcccagccgg ctctaagatt   5407

 cttaatgtta gagaaccgaa tgtgttagga aacagttgga aacgatgttc cacatccttg   5467

 agcactccta gtccaaggaa tttgagatca gcagctttcc acagttaatt acccaggttt   5527

 gatttggtca gtggtaaaga gtgcaggagt tagaggttta atctgaacac aagagatgac   5587

 tgagtgagaa gattgttttg attttactgc gcccctagga ctcaaaatag tgccttcttc   5647

 atagcaggca tttgctgttg actgactgac tgaatgcatg aatatcaatt tcctagacta   5707

 tggatggatg ctacaagaaa gatgggtttt ctcattcacc tcactgcaga gcctttcagg   5767

 gcagccttaa gtcagctaga gcaccagcta aacatgcagg tcctgacaac aaaatcattt   5827

 tgattgcatg ccataaactc tttgattaag aggattgatt aagataatct ggccttgctg   5887

 agtggtggtg gttttacctt gagctttacc agttattttg tcaggtagca ttccattaaa   5947

 ttaggatgca tcatctttga gactgatgga tttttgattc atttttccga gttttattga   6007

 atttggaatg acaccgagat cccaatagcc tgtacaaagt gaagacagta ggtcaacaac   6067

 agagccattc ttgataatac agaatatttc acaccaggca cggtggctcg cgcctctaat   6127

 cccaacattt gggaagccaa gggaagagga ttgcttgagg ccaggagttc gagaacagcc   6187

 taggcaacat agtaagaccc catctctgag aaaat                              6222




      <210> 217
      <211> 1412
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (74)..(1156)

      <400> 217
 gcaggaattc cgcacgagcc cttcgcaagc cctcatttca ccaggccccc ggcttggggc     60

 gccttccttc ccc   atg gcg gga cac ctg gct tca gat ttc gcc ttc tcg     109
                  Met Ala Gly His Leu Ala Ser Asp Phe Ala Phe Ser
                    1               5                  10

 ccc cct cca ggt ggt gga ggt gat ggg cca ggg ggg ccg gag ccg ggc      157
 Pro Pro Pro Gly Gly Gly Gly Asp Gly Pro Gly Gly Pro Glu Pro Gly
          15                  20                  25

 tgg gtt gat cct cgg acc tgg cta agc ttc caa ggc cct cct gga ggg      205
 Trp Val Asp Pro Arg Thr Trp Leu Ser Phe Gln Gly Pro Pro Gly Gly
      30                  35                  40

 cca gga atc ggg ccg ggg gtt ggg cca ggc tct gag gtg tgg ggg att      253
 Pro Gly Ile Gly Pro Gly Val Gly Pro Gly Ser Glu Val Trp Gly Ile
  45                  50                  55                  60

 ccc cca tgc ccc ccg ccg tat gag ttc tgt ggg ggg atg gcg tac tgt      301
 Pro Pro Cys Pro Pro Pro Tyr Glu Phe Cys Gly Gly Met Ala Tyr Cys
                  65                  70                  75

 ggg ccc cag gtt gga gtg ggg cta gtg ccc caa ggc ggc ttg gag acc      349
 Gly Pro Gln Val Gly Val Gly Leu Val Pro Gln Gly Gly Leu Glu Thr
              80                  85                  90

 tct cag cct gag ggt gaa gca gga gtc ggg gtg gag agc aac tcc gat      397
 Ser Gln Pro Glu Gly Glu Ala Gly Val Gly Val Glu Ser Asn Ser Asp
          95                 100                 105

 ggg gcc tcc ccg gag ccc tgc acc gtc acc cct ggt gcc gtg aag ctg      445
 Gly Ala Ser Pro Glu Pro Cys Thr Val Thr Pro Gly Ala Val Lys Leu
     110                 115                 120

 gag aag gag aag ctg gag caa aac ccg gag gag tcc cag gac atc aaa      493
 Glu Lys Glu Lys Leu Glu Gln Asn Pro Glu Glu Ser Gln Asp Ile Lys
 125                 130                 135                 140

 gct ctg cag aaa gaa ctc gag caa ttt gcc aag ctc ctg aag cag aag      541
 Ala Leu Gln Lys Glu Leu Glu Gln Phe Ala Lys Leu Leu Lys Gln Lys
                 145                 150                 155

 agg atc acc ctg gga tat aca cag gcc gat gtg ggg ctc acc ctg ggg      589
 Arg Ile Thr Leu Gly Tyr Thr Gln Ala Asp Val Gly Leu Thr Leu Gly
             160                 165                 170

 gtt cta ttt ggg aag gta ttc agc caa acg acc atc tgc cgc ttt gag      637
 Val Leu Phe Gly Lys Val Phe Ser Gln Thr Thr Ile Cys Arg Phe Glu
         175                 180                 185

 gct ctg cag ctt agc ttc aag aac atg tgt aag ctg cgg ccc ttg ctg      685
 Ala Leu Gln Leu Ser Phe Lys Asn Met Cys Lys Leu Arg Pro Leu Leu
     190                 195                 200

 cag aag tgg gtg gag gaa gct gac aac aat gaa aat ctt cag gag ata      733
 Gln Lys Trp Val Glu Glu Ala Asp Asn Asn Glu Asn Leu Gln Glu Ile
 205                 210                 215                 220

 tgc aaa gca gaa acc ctc gtg cag gcc cga aag aga aag cga acc agt      781
 Cys Lys Ala Glu Thr Leu Val Gln Ala Arg Lys Arg Lys Arg Thr Ser
                 225                 230                 235

 atc gag aac cga gtg aga ggc aac ctg gag aat ttg ttc ctg cag tgc      829
 Ile Glu Asn Arg Val Arg Gly Asn Leu Glu Asn Leu Phe Leu Gln Cys
             240                 245                 250

 ccg aaa ccc aca ctg cag cag atc agc cac atc gcc cag cag ctt ggg      877
 Pro Lys Pro Thr Leu Gln Gln Ile Ser His Ile Ala Gln Gln Leu Gly
         255                 260                 265

 ctc gag aag gat gtg gtc cga gtg tgg ttc tgt aac cgg cgc cag aag      925
 Leu Glu Lys Asp Val Val Arg Val Trp Phe Cys Asn Arg Arg Gln Lys
     270                 275                 280

 ggc aag cga tca agc agc gac tat gca caa cga gag gat ttt gag gct      973
 Gly Lys Arg Ser Ser Ser Asp Tyr Ala Gln Arg Glu Asp Phe Glu Ala
 285                 290                 295                 300

 gct ggg tct cct ttc tca ggg gga cca gtg tcc ttt cct ctg gcc cca     1021
 Ala Gly Ser Pro Phe Ser Gly Gly Pro Val Ser Phe Pro Leu Ala Pro
                 305                 310                 315

 ggg ccc cat ttt ggt acc cca ggc tat ggg agc cct cac ttc act gca     1069
 Gly Pro His Phe Gly Thr Pro Gly Tyr Gly Ser Pro His Phe Thr Ala
             320                 325                 330

 ctg tac tcc tcg gtc cct ttc cct gag ggg gaa gcc ttt ccc cct gtc     1117
 Leu Tyr Ser Ser Val Pro Phe Pro Glu Gly Glu Ala Phe Pro Pro Val
         335                 340                 345

 tct gtc acc act ctg ggc tct ccc atg cat tca aac tga ggtgcctgcc      1166
 Ser Val Thr Thr Leu Gly Ser Pro Met His Ser Asn 
     350                 355                 360

 cttctaggaa tgggggacag ggggagggga ggagctaggg aaagaaaacc tggagtttgt   1226

 gccagggttt ttgggattaa gttcttcatt cactaaggaa ggaattggga acacaaaggg   1286

 tgggggcagg ggagtttggg gcaactggtt ggagggaagg tgaagttcaa tgatgctctt   1346

 gattttaatc ccacatcatg tatcactttt ttcttaaata aagaagcttg ggacacagta   1406

 aaaaaa                                                              1412




      <210> 218
      <211> 365
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (16)..(345)

      <400> 218
 gagagagcta gcacc atg agc ttc aat acc ctg ctc cat cat cct ggc tcc      51
                  Met Ser Phe Asn Thr Leu Leu His His Pro Gly Ser
                    1               5                  10

 ctg ctc cat cat ccc ggc ttc cct gct cca tca tcc cgg ctt ccc tgc       99
 Leu Leu His His Pro Gly Phe Pro Ala Pro Ser Ser Arg Leu Pro Cys
          15                  20                  25

 tcc atc atc cca gct tcc ctc ctc cat cat ccc aac tgc cgt gct cta      147
 Ser Ile Ile Pro Ala Ser Leu Leu His His Pro Asn Cys Arg Ala Leu
      30                  35                  40

 tca ttc cag ctc cag cgt gtt tca tcc cag atg gcg tgc tcc atc atc      195
 Ser Phe Gln Leu Gln Arg Val Ser Ser Gln Met Ala Cys Ser Ile Ile
  45                  50                  55                  60

 cca gct gta gtg ctc cat cat gcg agg tcc ccg gtc cat cat cct ggc      243
 Pro Ala Val Val Leu His His Ala Arg Ser Pro Val His His Pro Gly
                  65                  70                  75

 ccc ccc gct cca tca tcc tgg ctg cat ggt cca tct tcc tgc tcg cca      291
 Pro Pro Ala Pro Ser Ser Trp Leu His Gly Pro Ser Ser Cys Ser Pro
              80                  85                  90

 ctc tgt cat cac aac cgc ccc ctc cat cat cta ggc ctc cgt ggt aca      339
 Leu Cys His His Asn Arg Pro Leu His His Leu Gly Leu Arg Gly Thr
          95                 100                 105

 tca taa aggctccgtg caccatcata                                        365
 Ser 






      <210> 219
      <211> 2047
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (338)..(2047)

      <400> 219
 gcacgaggag cttttcagag ccaaggatag ctgagttgga aataagctga aatgaataca     60

 tgactgggaa taatggggac tgcctgtgag gcctctgaaa taattgaagg caagatgaag    120

 gaactatctg aagaaatcac tacactctta gagaatccct ctgttctcca gcaaacatgg    180

 gatgtaaagc ctcacaggga atctgataat acatacttct gtcaaccaga accagagggg    240

 tagttttctt ttccctccag aggcagcctt tggtacttaa aatatctgta gctgattaaa    300

 tttttcccaa caacctcact ggggagaaag tgtgttc atg ttt tgt cca gcg gat     355
                                          Met Phe Cys Pro Ala Asp
                                            1               5

 cag gat gtt agg atg acg agc aag agt cca ggt cac tgt gcc ttt gct      403
 Gln Asp Val Arg Met Thr Ser Lys Ser Pro Gly His Cys Ala Phe Ala
              10                  15                  20

 gtg ttg tat gga aag gat ggc agg gaa cat gct acc acc agg tgg ccc      451
 Val Leu Tyr Gly Lys Asp Gly Arg Glu His Ala Thr Thr Arg Trp Pro
          25                  30                  35

 att act cga gat gat cat cac aac cag atg atg cta acc tat atc ctc      499
 Ile Thr Arg Asp Asp His His Asn Gln Met Met Leu Thr Tyr Ile Leu
      40                  45                  50

 tac cct tcg cgt gct ttg tct ggg aag tct ttt ggc ccc atg tca gtt      547
 Tyr Pro Ser Arg Ala Leu Ser Gly Lys Ser Phe Gly Pro Met Ser Val
  55                  60                  65                  70

 tct att gca ttg aga gcc caa gag ccc ctg tgc aaa gac aac ggg ccg      595
 Ser Ile Ala Leu Arg Ala Gln Glu Pro Leu Cys Lys Asp Asn Gly Pro
                  75                  80                  85

 aga gct ctg aga ccc agt ggg gat gtg ctt ttc ctg act gac agg aca      643
 Arg Ala Leu Arg Pro Ser Gly Asp Val Leu Phe Leu Thr Asp Arg Thr
              90                  95                 100

 gtt ggt cag tgc cag aca ttg gcc gtc acc acc att tct cct aca gct      691
 Val Gly Gln Cys Gln Thr Leu Ala Val Thr Thr Ile Ser Pro Thr Ala
         105                 110                 115

 aag gtt ctg caa ccc aaa ggt gcc ata gaa aat cag cta gac ata aag      739
 Lys Val Leu Gln Pro Lys Gly Ala Ile Glu Asn Gln Leu Asp Ile Lys
     120                 125                 130

 gtt ctg cac gtc ccc acc aga ttc agg agc cca gct ggc ttc acc cag      787
 Val Leu His Val Pro Thr Arg Phe Arg Ser Pro Ala Gly Phe Thr Gln
 135                 140                 145                 150

 tgg atc ccg cac tgg ggc tgc agg tgg agc tgc ctg cca gtc ccg cac      835
 Trp Ile Pro His Trp Gly Cys Arg Trp Ser Cys Leu Pro Val Pro His
                 155                 160                 165

 cgt gtg ccc gca ctc ctc agc cct tgg gtt gtc gat ggg act ggg tgc      883
 Arg Val Pro Ala Leu Leu Ser Pro Trp Val Val Asp Gly Thr Gly Cys
             170                 175                 180

 cgt gga gca ggg ggc ggc gct cgt cag gga ggc tcg ggc cgc aca gga      931
 Arg Gly Ala Gly Gly Gly Ala Arg Gln Gly Gly Ser Gly Arg Thr Gly
         185                 190                 195

 gcc cac gga gcg ggg gga ggc tca ggc atg gcg ggc tgc agg tcc cga      979
 Ala His Gly Ala Gly Gly Gly Ser Gly Met Ala Gly Cys Arg Ser Arg
     200                 205                 210

 gcc ctg ccc cac ggg aag gca gct aag gcc cgg cga gaa atc cag cac     1027
 Ala Leu Pro His Gly Lys Ala Ala Lys Ala Arg Arg Glu Ile Gln His
 215                 220                 225                 230

 agc gct ggt ggg ccg gca ctg ctg ggg gac cca gcg cac cct ccg cag     1075
 Ser Ala Gly Gly Pro Ala Leu Leu Gly Asp Pro Ala His Pro Pro Gln
                 235                 240                 245

 ccg ctg gcc cgg gtg cta agc ccc tca ttg ccc ggg gcc cgc agg gcc     1123
 Pro Leu Ala Arg Val Leu Ser Pro Ser Leu Pro Gly Ala Arg Arg Ala
             250                 255                 260

 ggc cag ctg ctc cga ctg ccg ggc cgc caa gcc cac gcc cac ccg gaa     1171
 Gly Gln Leu Leu Arg Leu Pro Gly Arg Gln Ala His Ala His Pro Glu
         265                 270                 275

 ctc cag ctg gcc cgc aaa cgc cgc acg cag ccc cgg ttc ccg ctc gcg     1219
 Leu Gln Leu Ala Arg Lys Arg Arg Thr Gln Pro Arg Phe Pro Leu Ala
     280                 285                 290

 cct ctc cct cca cac ctc cct ggg aag cat gca gat ggg cag gtt gtg     1267
 Pro Leu Pro Pro His Leu Pro Gly Lys His Ala Asp Gly Gln Val Val
 295                 300                 305                 310

 gag agc gtg ggc tct gac ccc aca gca gca tct agg gtt gag tgt tta     1315
 Glu Ser Val Gly Ser Asp Pro Thr Ala Ala Ser Arg Val Glu Cys Leu
                 315                 320                 325

 caa ctc ccg aag ccc cag tgg gcg tgt gtt aca atg cgc ttt ttc agt     1363
 Gln Leu Pro Lys Pro Gln Trp Ala Cys Val Thr Met Arg Phe Phe Ser
             330                 335                 340

 ttt gcc gtc cac agg cag ctt gtg tta atc agc tca att aga ccc tct     1411
 Phe Ala Val His Arg Gln Leu Val Leu Ile Ser Ser Ile Arg Pro Ser
         345                 350                 355

 gtc tta ttg caa gga cag aag gct ttc tgt atc ccg ggt tct tgc ctt     1459
 Val Leu Leu Gln Gly Gln Lys Ala Phe Cys Ile Pro Gly Ser Cys Leu
     360                 365                 370

 agt gta ctg gaa aaa tcg gat cac acg tgg gcc tta ttg aat ggc gga     1507
 Ser Val Leu Glu Lys Ser Asp His Thr Trp Ala Leu Leu Asn Gly Gly
 375                 380                 385                 390

 agt agc tct cag cag atg gat ggg gag cca gaa ggg gga tgg agt ggg     1555
 Ser Ser Ser Gln Gln Met Asp Gly Glu Pro Glu Gly Gly Trp Ser Gly
                 395                 400                 405

 aag gtg ggg cct tgg agg acc ctg ggt aat aaa aat cca atg ggc aca     1603
 Lys Val Gly Pro Trp Arg Thr Leu Gly Asn Lys Asn Pro Met Gly Thr
             410                 415                 420

 acg tgg ttt cgg ctt tgc agc acg tgg ctt ctg gct gca gac gca gac     1651
 Thr Trp Phe Arg Leu Cys Ser Thr Trp Leu Leu Ala Ala Asp Ala Asp
         425                 430                 435

 tgg gac tac aca cca gct ctc ctg gat ctc cag ctt gct gcc tgc aga     1699
 Trp Asp Tyr Thr Pro Ala Leu Leu Asp Leu Gln Leu Ala Ala Cys Arg
     440                 445                 450

 tct tgg gac ttc tca gtt tcc ata atc atg tca gcc aat tcc tta caa     1747
 Ser Trp Asp Phe Ser Val Ser Ile Ile Met Ser Ala Asn Ser Leu Gln
 455                 460                 465                 470

 gaa atc tct ctg tct ata tat cct att ggt tct gtt ttc tgg aga acc     1795
 Glu Ile Ser Leu Ser Ile Tyr Pro Ile Gly Ser Val Phe Trp Arg Thr
                 475                 480                 485

 ctt act gat ata cag gtc aag gta gca ggt gct gtg gcc ttt ctt agg     1843
 Leu Thr Asp Ile Gln Val Lys Val Ala Gly Ala Val Ala Phe Leu Arg
             490                 495                 500

 ggg aca tct aga caa tcc tgg tca cca gtg aga ttt ggg gat gca gcc     1891
 Gly Thr Ser Arg Gln Ser Trp Ser Pro Val Arg Phe Gly Asp Ala Ala
         505                 510                 515

 cct att tat tac ctg gat ttt ctt aca gaa atg gtt cta gga gca cca     1939
 Pro Ile Tyr Tyr Leu Asp Phe Leu Thr Glu Met Val Leu Gly Ala Pro
     520                 525                 530

 gca ggc ttt tac cct tac ctg gga cag agg atg cat gga gat gga gga     1987
 Ala Gly Phe Tyr Pro Tyr Leu Gly Gln Arg Met His Gly Asp Gly Gly
 535                 540                 545                 550

 gga caa atc cag ttt tat cta gag aag att ggg gct aaa cca gaa act     2035
 Gly Gln Ile Gln Phe Tyr Leu Glu Lys Ile Gly Ala Lys Pro Glu Thr
                 555                 560                 565

 gca aaa ctg tga                                                     2047
 Ala Lys Leu 






      <210> 220
      <211> 1181
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (373)..(678)

      <400> 220
 ctcattacgc catgcttggc acgaggtggc acgagggctg caaggaaggg caccagcatg     60

 caggctgccc actggagggt ccgggtgctg cgggcaaaag ttcagcgctt gtccaccctc    120

 ccttagctct gactcagtgc atcctactgt ggggacatct cgtgagggga cacgaaatga    180

 ctgatctcac cctttcccag tattcagagc tgtgaacccc tgtggcgcag gactggcctg    240

 tgtctgttat tttggttgta aatcattctc ctgtggaatt ggcaaaagct acatttttac    300

 tgtccttacc agcaacagtt tgcgtcgtca catgctgtga gtgtgggctg tggtgtgtcc    360

 gtgtgtgtac at    atg tgt ata tgt ata tat cac gca gca gga gtg tca     408
                  Met Cys Ile Cys Ile Tyr His Ala Ala Gly Val Ser
                    1               5                  10

 ttc atg ctg ctg tcc cct ggt gaa gtg aca agt aca att aaa ggt ggc      456
 Phe Met Leu Leu Ser Pro Gly Glu Val Thr Ser Thr Ile Lys Gly Gly
          15                  20                  25

 tct gaa atg gcc tct ggt ttc ttg gga gtc ggg cag gga cct gca gga      504
 Ser Glu Met Ala Ser Gly Phe Leu Gly Val Gly Gln Gly Pro Ala Gly
      30                  35                  40

 ggc ttt ccc agc agg tgc aca gaa gga agc gct gag ccc act gtg tgc      552
 Gly Phe Pro Ser Arg Cys Thr Glu Gly Ser Ala Glu Pro Thr Val Cys
  45                  50                  55                  60

 aga ggg tgt gtg ccc agg gca ctg cca cgg ccc cca cca gca ttg gcc      600
 Arg Gly Cys Val Pro Arg Ala Leu Pro Arg Pro Pro Pro Ala Leu Ala
                  65                  70                  75

 tct gct ctg cag ggt ggg gtg ccc atc ctg ggg gct gtg tgt cat gct      648
 Ser Ala Leu Gln Gly Gly Val Pro Ile Leu Gly Ala Val Cys His Ala
              80                  85                  90

 cac ctg acc cag gtg tgt gtc ccg gtg tga a atcgaggagg ggactggaag      699
 His Leu Thr Gln Val Cys Val Pro Val 
          95                 100

 cccttccctg ccttgaaaca tgaaagctga ttttctgagc agcagatacg gtcagtggca    759

 aagctgcatc tgaagggcgg cctgggaagg ggccctgtgc tggccccggg tccgccccag    819

 aggagtccac acagcaccac ctccagaagg ggctgggccc ggggtcctgc aggcggcacc    879

 ttttggtaga gtttgtttcc ctggaaaatg gggaaaatgt ttcaagccag gtgagggggg    939

 aagttaacac tgaaatatgt attgttttta aaaatcaaat gcacacgcat ggaagctgct    999

 tgtccatgca ctggttttgt cactggcgtc ctggaatccg accgtgttgg ggtgcaggcg   1059

 ctgtcagact ccggctgatc ctggctcgag cacacacatc taagggccag gctggttccg   1119

 catggtgatc tccgtcttgt atgtctgaat gttggcctaa aataaagatt actgttgtaa   1179

 aa                                                                  1181




      <210> 221
      <211> 2385
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (464)..(2344)

      <400> 221
 cgcggctggg agaacggcgc gcgccccgct cggcagctgc ggcggcggct ggtgtaggcg     60

 ctcacgtcag ggctgggagg agggggttcg cagctcagag agagagagac atgaggcaac    120

 ctggcaggaa gcgagaaaga gttcggcgaa gaaggagtga gttctagaga cgccccgcga    180

 gcaggacccg cgcctgcagg agagcctggc cgacccggct cctcgccttc tctgcgcgct    240

 ctcccgcgtc cgctttcagc accccgagcg gagaacagtt cccggcagcc cgcagcgctg    300

 ccgagtggcc gccggccggc cgagtacccg gagctccagg gggctcagga gcaccctctg    360

 agaacccgct gtgcacccac cttttcccct cttttggtgg gcaagtaagc acgggggaaa    420

 agcatccggt ggcctcaggg agccctgaag aaaccgaagc aga  atg tac cag gga     475
                                                  Met Tyr Gln Gly
                                                    1

 cac atg cag aaa agt aaa gaa caa gga tat gga aaa cta agc agt gat      523
 His Met Gln Lys Ser Lys Glu Gln Gly Tyr Gly Lys Leu Ser Ser Asp
   5                  10                  15                  20

 gaa gac ctc gaa ata att gtt gat caa aag cag gga aaa ggc tct agg      571
 Glu Asp Leu Glu Ile Ile Val Asp Gln Lys Gln Gly Lys Gly Ser Arg
                  25                  30                  35

 gcg gca gat aag gct gtt gcc atg gtg atg aag gag ata ccg agg gag      619
 Ala Ala Asp Lys Ala Val Ala Met Val Met Lys Glu Ile Pro Arg Glu
              40                  45                  50

 gag tct gct gaa gaa aag ccc ctc ctt act atg aca tca cag ctg gtg      667
 Glu Ser Ala Glu Glu Lys Pro Leu Leu Thr Met Thr Ser Gln Leu Val
          55                  60                  65

 aat gag caa caa gaa agc aga ccc ctc ctg agt ccc tcc atc gat gac      715
 Asn Glu Gln Gln Glu Ser Arg Pro Leu Leu Ser Pro Ser Ile Asp Asp
      70                  75                  80

 ttt ctc tgt gaa acc aaa tcg gaa gca ata gca agg cca gta aca tcc      763
 Phe Leu Cys Glu Thr Lys Ser Glu Ala Ile Ala Arg Pro Val Thr Ser
  85                  90                  95                 100

 aat aca gct gta ttg acc act ggc tta gat ctc ctc gac ctg agt gaa      811
 Asn Thr Ala Val Leu Thr Thr Gly Leu Asp Leu Leu Asp Leu Ser Glu
                 105                 110                 115

 cca gtc tct caa acc caa acc aaa gcc aag aag tca gag ccc tca tca      859
 Pro Val Ser Gln Thr Gln Thr Lys Ala Lys Lys Ser Glu Pro Ser Ser
             120                 125                 130

 aaa acc tca tcc ctc aag aaa aag gcc gat gga tct gac ctc atc agc      907
 Lys Thr Ser Ser Leu Lys Lys Lys Ala Asp Gly Ser Asp Leu Ile Ser
         135                 140                 145

 acg gat gct gag cag aga ggc cag cct ctc aga gtc ccg gag act tca      955
 Thr Asp Ala Glu Gln Arg Gly Gln Pro Leu Arg Val Pro Glu Thr Ser
     150                 155                 160

 tcc tta gat cta gac att caa aca caa ctg gaa aaa tgg gac gat gtt     1003
 Ser Leu Asp Leu Asp Ile Gln Thr Gln Leu Glu Lys Trp Asp Asp Val
 165                 170                 175                 180

 aag ttt cat gga gat cga aat acc aag gga cat cca atg gca gag aga     1051
 Lys Phe His Gly Asp Arg Asn Thr Lys Gly His Pro Met Ala Glu Arg
                 185                 190                 195

 aaa tca tcc tca tct aga act gga tca aaa gag ctc tta tgg tcc tca     1099
 Lys Ser Ser Ser Ser Arg Thr Gly Ser Lys Glu Leu Leu Trp Ser Ser
             200                 205                 210

 gaa cac aga tct caa cca gaa ctg agt ggt gga aaa agc gcc ctc aac     1147
 Glu His Arg Ser Gln Pro Glu Leu Ser Gly Gly Lys Ser Ala Leu Asn
         215                 220                 225

 tct gag tcg gct tca gaa ttg gaa tta gtg gct ccg act cag gct cga     1195
 Ser Glu Ser Ala Ser Glu Leu Glu Leu Val Ala Pro Thr Gln Ala Arg
     230                 235                 240

 ctg acc aaa gaa cat cgc tgg gga agc gca tta ctt tct aga aac cac     1243
 Leu Thr Lys Glu His Arg Trp Gly Ser Ala Leu Leu Ser Arg Asn His
 245                 250                 255                 260

 tcc tta gaa gaa gag ttt gaa agg gca aaa gca gca gtg gag tca gat     1291
 Ser Leu Glu Glu Glu Phe Glu Arg Ala Lys Ala Ala Val Glu Ser Asp
                 265                 270                 275

 aca gag ttt tgg gat aag atg caa gca gaa tgg gaa gaa atg gct cgg     1339
 Thr Glu Phe Trp Asp Lys Met Gln Ala Glu Trp Glu Glu Met Ala Arg
             280                 285                 290

 agg aac tgg ata tct gag aac caa gaa gcc cag aac caa gta acc atc     1387
 Arg Asn Trp Ile Ser Glu Asn Gln Glu Ala Gln Asn Gln Val Thr Ile
         295                 300                 305

 tcg gct agt gag aag gga tat tac ttt cac act gaa aac ccc ttc aag     1435
 Ser Ala Ser Glu Lys Gly Tyr Tyr Phe His Thr Glu Asn Pro Phe Lys
     310                 315                 320

 gac tgg cct gga gca ttt gaa gaa ggc tta aaa agg ctg aag gaa ggg     1483
 Asp Trp Pro Gly Ala Phe Glu Glu Gly Leu Lys Arg Leu Lys Glu Gly
 325                 330                 335                 340

 gat ctg cca gtc acc atc ctg ttc atg gaa gca gca att ctt cag gac     1531
 Asp Leu Pro Val Thr Ile Leu Phe Met Glu Ala Ala Ile Leu Gln Asp
                 345                 350                 355

 cct gga gat gca gag gca tgg cag ttc ctc ggg ata acc cag gcg gag     1579
 Pro Gly Asp Ala Glu Ala Trp Gln Phe Leu Gly Ile Thr Gln Ala Glu
             360                 365                 370

 aat gaa aat gaa caa gca gct att gtc gcc ctc cag agg tgc tta gaa     1627
 Asn Glu Asn Glu Gln Ala Ala Ile Val Ala Leu Gln Arg Cys Leu Glu
         375                 380                 385

 tta cag ccc aac aac tta aaa gct ttg atg gcc ttg gct gtg agt tat     1675
 Leu Gln Pro Asn Asn Leu Lys Ala Leu Met Ala Leu Ala Val Ser Tyr
     390                 395                 400

 act aac act ggc cat cag cag gat gcc tgt gac gct ctg aag aat tgg     1723
 Thr Asn Thr Gly His Gln Gln Asp Ala Cys Asp Ala Leu Lys Asn Trp
 405                 410                 415                 420

 att aag caa aat cca aag tac aaa tac ctt gtg aaa agc aag aag gga     1771
 Ile Lys Gln Asn Pro Lys Tyr Lys Tyr Leu Val Lys Ser Lys Lys Gly
                 425                 430                 435

 tct cca ggc ctc acc cgg cgg atg tct aag tcc cca gtt gat agc tct     1819
 Ser Pro Gly Leu Thr Arg Arg Met Ser Lys Ser Pro Val Asp Ser Ser
             440                 445                 450

 gtt ctg gaa ggg gtg aag gaa tta tat ctg gaa gct gcc cac caa aat     1867
 Val Leu Glu Gly Val Lys Glu Leu Tyr Leu Glu Ala Ala His Gln Asn
         455                 460                 465

 gga gat atg atc gac cca gac ctg cag aca ggt cta ggg gtt ctg ttc     1915
 Gly Asp Met Ile Asp Pro Asp Leu Gln Thr Gly Leu Gly Val Leu Phe
     470                 475                 480

 cac ctg agt gga gaa ttt aat aga gca ata gat gca ttt aac gct gcc     1963
 His Leu Ser Gly Glu Phe Asn Arg Ala Ile Asp Ala Phe Asn Ala Ala
 485                 490                 495                 500

 tta act gtt cgg cca gag gac tat tca cta tgg aac cgc ctc ggg gcg     2011
 Leu Thr Val Arg Pro Glu Asp Tyr Ser Leu Trp Asn Arg Leu Gly Ala
                 505                 510                 515

 acc ttg gcg aac gga gac cgc agc gag gaa gcc gtg gag gcc tat acg     2059
 Thr Leu Ala Asn Gly Asp Arg Ser Glu Glu Ala Val Glu Ala Tyr Thr
             520                 525                 530

 cga gca ctg gag att cag cca gga ttc atc cgg tcc aga tac aac cta     2107
 Arg Ala Leu Glu Ile Gln Pro Gly Phe Ile Arg Ser Arg Tyr Asn Leu
         535                 540                 545

 gga ata agc tgc atc aac ctg ggc gcc tac aga gaa gcg gtc agc aat     2155
 Gly Ile Ser Cys Ile Asn Leu Gly Ala Tyr Arg Glu Ala Val Ser Asn
     550                 555                 560

 ttt ctc act gcc ctc agt ttg caa aga aag agc agg aat cag cag caa     2203
 Phe Leu Thr Ala Leu Ser Leu Gln Arg Lys Ser Arg Asn Gln Gln Gln
 565                 570                 575                 580

 gtt cct cat cct gca atc tct ggg aat atc tgg gct gcc ctc aga att     2251
 Val Pro His Pro Ala Ile Ser Gly Asn Ile Trp Ala Ala Leu Arg Ile
                 585                 590                 595

 gcg ctc tct ctg atg gac caa cca gaa ctc ttc cag gcg gct aat ctt     2299
 Ala Leu Ser Leu Met Asp Gln Pro Glu Leu Phe Gln Ala Ala Asn Leu
             600                 605                 610

 ggt gac ctg gat gtc ctc tta aga gct ttc aac ttg gat cct tga aga     2347
 Gly Asp Leu Asp Val Leu Leu Arg Ala Phe Asn Leu Asp Pro 
         615                 620                 625

 aagaataata ccagtactaa taatcccaaa aaaaaaaa                           2385




      <210> 222
      <211> 551
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (179)..(427)

      <400> 222
 gggaattccc gggtcgactt cgctgtcgac gatttcgtag caagagaaaa agcaagaaca     60

 agaggacaac ttagccgaga tcaccaacct cctgcgtggg gacctgctct ccgagaaccc    120

 gcagcaggca gccagctcct tggggcccca ccgcgtggtc cctgaccgct ggaagggc      178                                                                 
 atg acc cag gag cag ctg gag cag atc cgc cta gtc cag aag cag caa      226
 Met Thr Gln Glu Gln Leu Glu Gln Ile Arg Leu Val Gln Lys Gln Gln
   1               5                  10                  15

 atc cag gag aag ctg agg ctc cag gaa gaa aag cgc cag cga gac ctg      274
 Ile Gln Glu Lys Leu Arg Leu Gln Glu Glu Lys Arg Gln Arg Asp Leu
              20                  25                  30

 gac tgg gac cgg cgg agg att cag ggg gct cgc gcc acc ctg ctg ttt      322
 Asp Trp Asp Arg Arg Arg Ile Gln Gly Ala Arg Ala Thr Leu Leu Phe
          35                  40                  45

 gag cgg cag cag tgg cgg cag cag cgc gac ctg cgc aga gct ctg gac      370
 Glu Arg Gln Gln Trp Arg Gln Gln Arg Asp Leu Arg Arg Ala Leu Asp
      50                  55                  60

 agc agc aac ctc agc ctg gcc aag gag cag cat ttg cag aaa aaa tat      418
 Ser Ser Asn Leu Ser Leu Ala Lys Glu Gln His Leu Gln Lys Lys Tyr
  65                  70                  75                  80

 atg aaa tag tctcccg tgggttgatt tgtatagact tcattcatat aatttaatac      474
 Met Lys 


 aggaagtcga taatgaggaa cacacccttg ttcccgtcat tcacgtataa agagtggcta    534

 ccctcagaac aacgaca                                                   551




      <210> 223
      <211> 2575
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (947)..(2239)

      <400> 223
 aagtcccggg tcgacgattt cgtccgctgc tgccgccacc actgcgtcgg gctggtgcag     60

 ccccgggcca ggccgcggcc ggggcaggag cgcaggggct ttgttatgca cctaaagcca    120

 tattggaagc tccagaagaa agagcacccc ccggaagtca gcagggaaac gcagagaact    180

 cctatgaacc accaaaaggc tgtaaatgat gaaacatgca aagctagcca cataacatca    240

 agtgtctttc cttcagcctc tctcggtaaa gcatcatctc gaaagccatt tgggatcctt    300

 tctccaaatg ttctgtgcag tatgagtggg aagagtcctg tagagagcag cttgaatgtt    360

 aaaaccaaaa agaatgcacc atctgcaacg atccaccagg gcgaagaaga aggaccactt    420

 gatatctggg ctgttgtgaa acctggaaat accaaggaaa aaattgcatt ctttgcatcc    480

 caccagtgta gtaacaggat aggatctatg aaaataaaaa gttcctggga tattgatggg    540

 agagctacta agagaaggaa aaaatcaggg gatcttaaaa aagccaaggt acaggtggaa    600

 aggatgaggg aggttaacag caggtgctac caacctgagc cttttgcatg tggcattgag    660

 cactgttctg tgcactatgt gagtgacagt ggggatggag tctatgctgg gaggcctctg    720

 tcagttatac agatggttgc cttcttggag caaagagcca gtgctctgct agctagctgt    780

 tcaaaactgc acaaactcac ctgcaattgt gaggttttct ggccaatcca gaggtgtgcc    840

 tgcagtgtct gagtcctatt ctgccccagg agcttgtgaa gaacccacag aaaggggaaa    900

 tcttgaggtt ggtgaaccac agagcgaacc agtccgtgtc cttgac   atg gta gcc     955
                                                      Met Val Ala
                                                        1

 aag ttg gag tct gag tgc ctg aag cgg cag ggc cag cgt gag cct ggg     1003
 Lys Leu Glu Ser Glu Cys Leu Lys Arg Gln Gly Gln Arg Glu Pro Gly
       5                  10                  15

 agc ctc tca agg aat aac agc ttc cgt cga aat gtg ggc aga gta ttg     1051
 Ser Leu Ser Arg Asn Asn Ser Phe Arg Arg Asn Val Gly Arg Val Leu
  20                  25                  30                  35

 ctt gca aat agc act cag gct gat gaa ggc aaa aca aag aaa ggc gtc     1099
 Leu Ala Asn Ser Thr Gln Ala Asp Glu Gly Lys Thr Lys Lys Gly Val
                  40                  45                  50

 ttg gag gca cct gac act cag gtg aat cct gtg ggg tct gta tct gtg     1147
 Leu Glu Ala Pro Asp Thr Gln Val Asn Pro Val Gly Ser Val Ser Val
              55                  60                  65

 gat tgt ggc cct tca aga gct gat cgt tgt tct cct aag gag gac cag     1195
 Asp Cys Gly Pro Ser Arg Ala Asp Arg Cys Ser Pro Lys Glu Asp Gln
          70                  75                  80

 gcc tgg gac ggt gct tct cag gac tgc ccc cca ttg cca gca gga gtg     1243
 Ala Trp Asp Gly Ala Ser Gln Asp Cys Pro Pro Leu Pro Ala Gly Val
      85                  90                  95

 agt ttc cac ata gac agt gca gag tta gag ccg ggt tcg caa act gcc     1291
 Ser Phe His Ile Asp Ser Ala Glu Leu Glu Pro Gly Ser Gln Thr Ala
 100                 105                 110                 115

 gtg aaa aac agc aac aga tat gat gtg gaa atg aca gat gaa ctc gtt     1339
 Val Lys Asn Ser Asn Arg Tyr Asp Val Glu Met Thr Asp Glu Leu Val
                 120                 125                 130

 ggg tta cct ttt tcc tct cat acc tat tcc caa gcc tct gaa ttg ccc     1387
 Gly Leu Pro Phe Ser Ser His Thr Tyr Ser Gln Ala Ser Glu Leu Pro
             135                 140                 145

 aca gat gct gtt gat tgt atg agc aga gag ctt gtg tcc ctt act agc     1435
 Thr Asp Ala Val Asp Cys Met Ser Arg Glu Leu Val Ser Leu Thr Ser
         150                 155                 160

 cga aat cct gat caa aga aaa gaa tct ttg tgc att agt atc act gtg     1483
 Arg Asn Pro Asp Gln Arg Lys Glu Ser Leu Cys Ile Ser Ile Thr Val
     165                 170                 175

 tcc aag gta gac aaa gac cag cct tcc aat tta aac tcc tgt gaa gac     1531
 Ser Lys Val Asp Lys Asp Gln Pro Ser Asn Leu Asn Ser Cys Glu Asp
 180                 185                 190                 195

 cca gtt cca ggg atg ttg ttt ttt ttg cca cct ggt cag cac ttg tca     1579
 Pro Val Pro Gly Met Leu Phe Phe Leu Pro Pro Gly Gln His Leu Ser
                 200                 205                 210

 gac tat tcc cag ttg aat gaa agc aca aca aaa gag tct tca gag gcc     1627
 Asp Tyr Ser Gln Leu Asn Glu Ser Thr Thr Lys Glu Ser Ser Glu Ala
             215                 220                 225

 agc cag ctt gaa gat gct gct ggg ggt gac agt gca tct gag gaa aaa     1675
 Ser Gln Leu Glu Asp Ala Ala Gly Gly Asp Ser Ala Ser Glu Glu Lys
         230                 235                 240

 agt ggg tct gct gag cca ttt gta ctg cca gcc tct tct gtg gaa agt     1723
 Ser Gly Ser Ala Glu Pro Phe Val Leu Pro Ala Ser Ser Val Glu Ser
     245                 250                 255

 aca tta cca gtg ctt gag gca tcc agt tgg aag aag cag gtg tcg cat     1771
 Thr Leu Pro Val Leu Glu Ala Ser Ser Trp Lys Lys Gln Val Ser His
 260                 265                 270                 275

 gac ttc ctg gag acc agg ttt aaa atc cag cag ctt ttg gag cct cag     1819
 Asp Phe Leu Glu Thr Arg Phe Lys Ile Gln Gln Leu Leu Glu Pro Gln
                 280                 285                 290

 cag tac atg gct ttt ctg ccc cac cac att atg gta aaa atc ttc agg     1867
 Gln Tyr Met Ala Phe Leu Pro His His Ile Met Val Lys Ile Phe Arg
             295                 300                 305

 tta ctt ccc acc aag agt tta gtg gcc ctt aaa tgt acc tgc tgc tat     1915
 Leu Leu Pro Thr Lys Ser Leu Val Ala Leu Lys Cys Thr Cys Cys Tyr
         310                 315                 320

 ttc aag ttt atc att gag tac tac aat atc agg cca gca gat tct cgc     1963
 Phe Lys Phe Ile Ile Glu Tyr Tyr Asn Ile Arg Pro Ala Asp Ser Arg
     325                 330                 335

 tgg gtt cga gat cca cgc tat aga gag gat cct tgc aaa cag tgc aag     2011
 Trp Val Arg Asp Pro Arg Tyr Arg Glu Asp Pro Cys Lys Gln Cys Lys
 340                 345                 350                 355

 aaa aag tat gtg aaa ggg gat gtg tcc ctg tgc cga tgg cac ccc aag     2059
 Lys Lys Tyr Val Lys Gly Asp Val Ser Leu Cys Arg Trp His Pro Lys
                 360                 365                 370

 ccc tat tgc cag gca ttg ccc tat ggg cca ggg tat tgg atg tgc tgc     2107
 Pro Tyr Cys Gln Ala Leu Pro Tyr Gly Pro Gly Tyr Trp Met Cys Cys
             375                 380                 385

 cac cgg tct cag aaa gga ttc cct ggc tgt aag ctg ggg ctt cat gac     2155
 His Arg Ser Gln Lys Gly Phe Pro Gly Cys Lys Leu Gly Leu His Asp
         390                 395                 400

 aat cac tgg gtt cct gcc tgc cac agc ttt aat cgg gca atc cat aag     2203
 Asn His Trp Val Pro Ala Cys His Ser Phe Asn Arg Ala Ile His Lys
     405                 410                 415

 aaa gca aaa ggg act gaa gct gaa gag gaa tac taa agtc catctgagag     2253
 Lys Ala Lys Gly Thr Glu Ala Glu Glu Glu Tyr 
 420                 425                 430

 gcaacaaaag gaccggtttc taaagctgca aaacacctaa atacaccgtt caaatgagcg   2313

 tagccccctg agtcatcact ctaaaaaaat ctgtacatca tcaggactgc attgctcagg   2373

 cattttctaa actctaaatt tacgagctgt acaaaaaaat tggtcttgtt gtttatagtg   2433

 gcatctcatg tttgaacccg ggtggtatcc cacagttgga ttcagttggc tgtgaataac   2493

 tgcctgtttt cctaaatcaa acccatcctc aaaggatgaa gactcaccac catccaggac   2553

 attcagaaga gttcactgcg gg                                            2575




      <210> 224
      <211> 835
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (72)..(650)

      <400> 224
 gaagatggtg gcgcccagag cttcgctctt gctgctcccc tgaggtgaac tgaagccagc     60

 agccccgcat c atg tca aag ctc ggc cgg gcc gcc cgg ggc ctc agg aag     110
              Met Ser Lys Leu Gly Arg Ala Ala Arg Gly Leu Arg Lys
                1               5                  10

 ccc gag gtc ggc ggt gtg atc cgg gcg atc gtg cgg gca ggc ctg gcc      158
 Pro Glu Val Gly Gly Val Ile Arg Ala Ile Val Arg Ala Gly Leu Ala
      15                  20                  25

 atg ccc ggg ccc cca cta ggc cca gtg ctg ggt cag aga ggc gtt tcc      206
 Met Pro Gly Pro Pro Leu Gly Pro Val Leu Gly Gln Arg Gly Val Ser
  30                  35                  40                  45

 atc aac cag ttt tgc aag gag ttc aat gag agg aca aag gac atc aag      254
 Ile Asn Gln Phe Cys Lys Glu Phe Asn Glu Arg Thr Lys Asp Ile Lys
                  50                  55                  60

 gaa ggc att cct ctg cct acc aag att tta gtg aag cct gac agg aca      302
 Glu Gly Ile Pro Leu Pro Thr Lys Ile Leu Val Lys Pro Asp Arg Thr
              65                  70                  75

 ttt gaa att aag att gga cag ccc act gtt tcc tac ttc ctg aag gca      350
 Phe Glu Ile Lys Ile Gly Gln Pro Thr Val Ser Tyr Phe Leu Lys Ala
          80                  85                  90

 gca gct ggg att gaa aag ggg gcc cgg caa aca ggg aaa gag gtg gca      398
 Ala Ala Gly Ile Glu Lys Gly Ala Arg Gln Thr Gly Lys Glu Val Ala
      95                 100                 105

 ggc ctg gtg acc ttg aag cat gtg tat gag att gcc cgc atc aaa gct      446
 Gly Leu Val Thr Leu Lys His Val Tyr Glu Ile Ala Arg Ile Lys Ala
 110                 115                 120                 125

 cag gat gag gca ttt gcc ctg cag gat gta ccc ctg tcg tct gtt gtc      494
 Gln Asp Glu Ala Phe Ala Leu Gln Asp Val Pro Leu Ser Ser Val Val
                 130                 135                 140

 cgc tcc atc atc ggg tct gcc cgt tct ctg ggc att cgc gtg gtg aag      542
 Arg Ser Ile Ile Gly Ser Ala Arg Ser Leu Gly Ile Arg Val Val Lys
             145                 150                 155

 gac ctc agt tca gaa gag ctt gca gct ttc cag aag gaa cga gcc atc      590
 Asp Leu Ser Ser Glu Glu Leu Ala Ala Phe Gln Lys Glu Arg Ala Ile
         160                 165                 170

 ttc ctg gct gct cag aag gag gca gat ttg gct gcc caa gaa gaa gct      638
 Phe Leu Ala Ala Gln Lys Glu Ala Asp Leu Ala Ala Gln Glu Glu Ala
     175                 180                 185

 gcc aag aag tga ccc ttgccccacc aactcccaga tttcaaagga ggtagttgca      693
 Ala Lys Lys 
 190

 aaagctgtgc ccaaggggag gaaggaggtc acaccaatat gatgatggtt ttcatgactt    753

 tgaatgatat atttttgtac atctagctgt atcgaggcat caggcctgaa taaacatcct    813

 ttcttaccca aaaaaaaaaa aa                                             835




      <210> 225
      <211> 757
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (72)..(572)

      <400> 225
 gaagatggtg gcgcccagag cttcgctctt gctgctcccc tgaggtgaac tgaagccagc     60

 agccccgcat c atg tca aag ctc ggc cgg gcc gcc cgg ggc ctc agg aag     110
              Met Ser Lys Leu Gly Arg Ala Ala Arg Gly Leu Arg Lys
                1               5                  10

 ccc gag aga ggc gtt tcc atc aac cag ttt tgc aag gag ttc aat gag      158
 Pro Glu Arg Gly Val Ser Ile Asn Gln Phe Cys Lys Glu Phe Asn Glu
      15                  20                  25

 agg aca aag gac atc aag gaa ggc att cct ctg cct acc aag att tta      206
 Arg Thr Lys Asp Ile Lys Glu Gly Ile Pro Leu Pro Thr Lys Ile Leu
  30                  35                  40                  45

 gtg aag cct gac agg aca ttt gaa att aag att gga cag ccc act gtt      254
 Val Lys Pro Asp Arg Thr Phe Glu Ile Lys Ile Gly Gln Pro Thr Val
                  50                  55                  60

 tcc tac ttc ctg aag gca gca gct ggg att gaa aag ggg gcc cgg caa      302
 Ser Tyr Phe Leu Lys Ala Ala Ala Gly Ile Glu Lys Gly Ala Arg Gln
              65                  70                  75

 aca ggg aaa gag gtg gca ggc ctg gtg acc ttg aag cat gtg tat gag      350
 Thr Gly Lys Glu Val Ala Gly Leu Val Thr Leu Lys His Val Tyr Glu
          80                  85                  90

 att gcc cgc atc aaa gct cag gat gag gca ttt gcc ctg cag gat gta      398
 Ile Ala Arg Ile Lys Ala Gln Asp Glu Ala Phe Ala Leu Gln Asp Val
      95                 100                 105

 ccc ctg tcg tct gtt gtc cgc tcc atc atc ggg tct gcc cgt tct ctg      446
 Pro Leu Ser Ser Val Val Arg Ser Ile Ile Gly Ser Ala Arg Ser Leu
 110                 115                 120                 125

 ggc att cgc gtg gtg aag gac ctc agt tca gaa gag ctt gca gct ttc      494
 Gly Ile Arg Val Val Lys Asp Leu Ser Ser Glu Glu Leu Ala Ala Phe
                 130                 135                 140

 cag aag gaa cga gcc atc ttc ctg gct gct cag aag gag gca gat ttg      542
 Gln Lys Glu Arg Ala Ile Phe Leu Ala Ala Gln Lys Glu Ala Asp Leu
             145                 150                 155

 gct gcc caa gaa gaa gct gcc aag aag tga c ccttgcccca ccaactccca      593
 Ala Ala Gln Glu Glu Ala Ala Lys Lys 
         160                 165

 gatttcaaag gaggtagttg caaaagctgt gcccaagggg aggaaggagg tcacaccaat    653

 atgatgatgg ttttcatgac tttgaatgat atatttttgt acatctagct gtatcgaggc    713

 atcaggcctg aataaacatc ctttcttacc caaaaaaaaa aaaa                     757




      <210> 226
      <211> 1906
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (147)..(1151)

      <220>
      <221> misc_feature
      <222> (1)...(1906)
      <223> n = a,t,c or g

      <400> 226
 atttttgttt ttaacagggg gcacttacac atggtgatag aagggcaaca gaatctagag     60

 atctgagcag gttcaacttt gataataagt atggaagaaa tgctttagaa attgtcataa    120

 aatccattgt aaacttggat tctcct atg gta tca cca cct cca gac tat cct     173
                              Met Val Ser Pro Pro Pro Asp Tyr Pro
                                1               5

 gga gaa ttt ttt aaa gat gtt cga caa gga ctg ata ggc gtt ggc ctg      221
 Gly Glu Phe Phe Lys Asp Val Arg Gln Gly Leu Ile Gly Val Gly Leu
  10                  15                  20                  25

 ata aat gta gaa gat cgc tcg gga att ctt act ctc gat aaa gat tat      269
 Ile Asn Val Glu Asp Arg Ser Gly Ile Leu Thr Leu Asp Lys Asp Tyr
                  30                  35                  40

 aac aac ata gga aaa ttc tta aat aga att tta ggc atg gag gtg cat      317
 Asn Asn Ile Gly Lys Phe Leu Asn Arg Ile Leu Gly Met Glu Val His
              45                  50                  55

 cag cag aat gag tta ttt cag tat ttt gcg gac aca ctt act gca gtt      365
 Gln Gln Asn Glu Leu Phe Gln Tyr Phe Ala Asp Thr Leu Thr Ala Val
          60                  65                  70

 gtt caa aat gcc aaa aaa aat gga aga tat gat atg gga atc tta gat      413
 Val Gln Asn Ala Lys Lys Asn Gly Arg Tyr Asp Met Gly Ile Leu Asp
      75                  80                  85

 ctt ggt tct gga gat gaa aaa gtg cgg aaa agt gat gtt aaa aag ttt      461
 Leu Gly Ser Gly Asp Glu Lys Val Arg Lys Ser Asp Val Lys Lys Phe
  90                  95                 100                 105

 ctg act cca gga tat tca acc tct ggc cac gta gaa tta tac aca att      509
 Leu Thr Pro Gly Tyr Ser Thr Ser Gly His Val Glu Leu Tyr Thr Ile
                 110                 115                 120

 agt gta gag agg gga atg tca tgg gag gaa gct acc aag att tgg gct      557
 Ser Val Glu Arg Gly Met Ser Trp Glu Glu Ala Thr Lys Ile Trp Ala
             125                 130                 135

 gag ctg aca gga cca gac gat ggc ttt tac ttg tca ttg caa ata agg      605
 Glu Leu Thr Gly Pro Asp Asp Gly Phe Tyr Leu Ser Leu Gln Ile Arg
         140                 145                 150

 aac aac aag aaa act gcc atc tta gtt aaa gaa gtg aat cct aaa aag      653
 Asn Asn Lys Lys Thr Ala Ile Leu Val Lys Glu Val Asn Pro Lys Lys
     155                 160                 165

 aaa ctt ttc tta gtt tat cga cca aat act ggg aag cag ctc aaa tta      701
 Lys Leu Phe Leu Val Tyr Arg Pro Asn Thr Gly Lys Gln Leu Lys Leu
 170                 175                 180                 185

 gaa att tat gct gat cta aaa aag aaa tat aag aag gtc gtc tca gat      749
 Glu Ile Tyr Ala Asp Leu Lys Lys Lys Tyr Lys Lys Val Val Ser Asp
                 190                 195                 200

 gat gcc ctg atg cac tgg tta gat cag tat aat tca tct gca gat act      797
 Asp Ala Leu Met His Trp Leu Asp Gln Tyr Asn Ser Ser Ala Asp Thr
             205                 210                 215

 tgt act cat gct tat tgg cgc ggc aat tgc aaa aaa gca agc ttg ggg      845
 Cys Thr His Ala Tyr Trp Arg Gly Asn Cys Lys Lys Ala Ser Leu Gly
         220                 225                 230

 cta gtt tgt gaa ata ggt ctt cgt ttc cgt aca tat tat gta tta tgt      893
 Leu Val Cys Glu Ile Gly Leu Arg Phe Arg Thr Tyr Tyr Val Leu Cys
     235                 240                 245

 ggt tca gtg ctg agt gtc tgg aca aaa gtt gag ggt gtt cta gca tct      941
 Gly Ser Val Leu Ser Val Trp Thr Lys Val Glu Gly Val Leu Ala Ser
 250                 255                 260                 265

 gtc agt ggc aca aac gtg aag atg cag atc gtg cgg cta ata acg gaa      989
 Val Ser Gly Thr Asn Val Lys Met Gln Ile Val Arg Leu Ile Thr Glu
                 270                 275                 280

 gat ggg caa cgg att gta ggt ttg atc att ccg gca aat tgt gtg tct     1037
 Asp Gly Gln Arg Ile Val Gly Leu Ile Ile Pro Ala Asn Cys Val Ser
             285                 290                 295

 cct ctt gta aat ctc cta tca act tca gac cag tct caa cag ctt gcg     1085
 Pro Leu Val Asn Leu Leu Ser Thr Ser Asp Gln Ser Gln Gln Leu Ala
         300                 305                 310

 gtc caa cag aaa cag cta tgg caa cag cat cac cct cag agc atc acc     1133
 Val Gln Gln Lys Gln Leu Trp Gln Gln His His Pro Gln Ser Ile Thr
     315                 320                 325

 aac ttg agc aac gca tga agaaca gacaggtttc aacatggatg gttctgaaat     1187
 Asn Leu Ser Asn Ala 
 330

 gctgttgaag catatcattt gcataaaaat cagggacagt ttccaaagaa ttatatattt   1247

 ttttcagttg tgctctctag ttagtttttt tgggagtaag gacaaacctg gaataaatag   1307

 caaaactgaa aatcaacagt gctgatgggg gtacatatgt ctttccttta acttctcccc   1367

 tgataactcc catctgcttt tacttcgggt gagcanaggg ggatgtgtgt gtgcgtgtgt   1427

 gtcaatctgt ttgtgagtgt gttaaaggct acagaccaca gttggtttaa aatgcttgga   1487

 acttcccaaa ctggctttac tttatgttta tacagtgctc agggttaacg cagtacatcc   1547

 atgccattgc tgtgggaggt atccccggat gcatgtgttt tgagtctata aatatagaaa   1607

 atatatattg gtttcttttt ccaacttaat aggtttatta aagcatgaaa tgaaaggttg   1667

 catatcatgc attcagggta ttttctaatt tttgttctga cagcgcatgt ctttggaagc   1727

 atgctggaac aagattaaca caggaggcga gtggcagaga gaaacatttg ttagatgtac   1787

 cgcattggtt attgcatttt tatagtgggt atacctgggg attgggttaa accctgcaga   1847

 cccctcctta cccttttccc tgtcctgggg ttctgggcaa gggaacgaac accatactt    1906




      <210> 227
      <211> 2058
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (582)..(1025)

      <400> 227
 ttgaaaatcg atcgccttga ggaaccgccc cggaattccc gggtcgaccc acgcggccgg     60

 cccccagccc cggctcagcc cgcagcatgg gcagccacac cacacgggac agcagctccc    120

 tctcgggctg cacctcaggc atcctggagg agcgcagccc tgccttccgg gggccggaca    180

 gggcccgggc tgctgtctca agacagccag acaaggagtt ctccttcatg gatgaggagg    240

 aggaggatga aatccgtgtg tgaggcggac agtgggtggc caccgggagc tcttggctgc    300

 atcttctccc tgcccccacc ccactatgac ctttgaccct acggcgcagg ggcagccagg    360

 acccttgatt cagaccatgg accctggacc ttgtagatga gggacactgg cctggccctc    420

 gggtcttcgg aggacgtagg gggctggcat gggtgccgac tggctgcctg acttcatcac    480

 gctccctgca cttaggctgc gtgggacaag ggctgtgttg tcacagcagg aataggtttt    540

 cctctgttgg cctccctttc ctccaccctg gcctcaaatg g    atg cca gat gcc     593
                                                  Met Pro Asp Ala
                                                    1

 aac ccc agt tct ggc cac gta cag cca gcg ggt cag ccc aga ggc agc      641
 Asn Pro Ser Ser Gly His Val Gln Pro Ala Gly Gln Pro Arg Gly Ser
   5                  10                  15                  20

 ctc agc tcc agg gct aag gac tct cgg ctc cca ttt tct ctg ctg gcg      689
 Leu Ser Ser Arg Ala Lys Asp Ser Arg Leu Pro Phe Ser Leu Leu Ala
                  25                  30                  35

 ttt ctg ctg tgc cca gca gtg gct gct ggg gaa gca gct gca gca gga      737
 Phe Leu Leu Cys Pro Ala Val Ala Ala Gly Glu Ala Ala Ala Ala Gly
              40                  45                  50

 ggg aga cgg tct tgc ctc tca gcc cct ccc tgc ccc acc cca gct cct      785
 Gly Arg Arg Ser Cys Leu Ser Ala Pro Pro Cys Pro Thr Pro Ala Pro
          55                  60                  65

 gcc ctg gaa atc tgg agc ccc ttg gag ctg agc tgg acg ggg ggc cag      833
 Ala Leu Glu Ile Trp Ser Pro Leu Glu Leu Ser Trp Thr Gly Gly Gln
      70                  75                  80

 ctg cga gca tgt gca cta aac gca gcc ctt tcc agg gga aga gaa cag      881
 Leu Arg Ala Cys Ala Leu Asn Ala Ala Leu Ser Arg Gly Arg Glu Gln
  85                  90                  95                 100

 gat gga gaa tgg aag gaa agc ccc cca ggc ttc gtg aat tgc aag aag      929
 Asp Gly Glu Trp Lys Glu Ser Pro Pro Gly Phe Val Asn Cys Lys Lys
                 105                 110                 115

 gga ccc ttc cag gat gac act agg aac agg gct agg gca ctc gct cag      977
 Gly Pro Phe Gln Asp Asp Thr Arg Asn Arg Ala Arg Ala Leu Ala Gln
             120                 125                 130

 tcc cta ggg gct tgt ttg ttc ttt att att gtg ttt aaa tcc tta tag     1025
 Ser Leu Gly Ala Cys Leu Phe Phe Ile Ile Val Phe Lys Ser Leu 
         135                 140                 145

 agcaatatca ggatggtgtt aataggtctg cctcagaatg agaatcaatc cttttagaaa   1085

 acctttatac taagcctcct cttcgaaatt cacagtggcg attagcggac tggagtctgg   1145

 tggcgattag cggactggag tctggggaca tccgtggcaa agacaccagc tcaactttag   1205

 tgcttcccaa ctttatttag aatgacatgg ggtgggtgtc tggtgtgtgt gttttcccta   1265

 cgcacctccc atagctatta acaactgagg aaggccagtg cagaatattt ttggagaacg   1325

 attttttttt taaataatat atcattccta tggggggaaa gccttttttt tttttttggc   1385

 tgagttattc cctccctccc ctcaataccc tcagtactga ctacttccct ttcttttctc   1445

 aggcctcccc ccaccgactt ttgaggccag ggttggccag atttagcaaa accaaaacag   1505

 agtgctgagt taaacgcaaa tttcaggtaa acaaaagata attttctagc attaatatgc   1565

 cccacgcaat atttggaaca cttatgtgaa aaatgatttg tttttctgaa atttacgttt   1625

 ctctctgagt cctgtaactg tccccgaggg gattgagcag aagctcgggt atgagccctg   1685

 aggttgactg ccggttattt ttctgtcctg ggaacagcct gacccacctc cctgtctcca   1745

 tgtagccagt ggggggaggg ggagacacag aaccaaccac agccaggggc gtccccatgg   1805

 cgactgtggc ccggcccctc ctctcttgcc tgactctcct ctcttgcctg actctagaca   1865

 ctaacttagt tccaggttcg gtgccctgtt ggtgctcctg tttccaatag cttaggtccc   1925

 atggtggggg aggaacctca ggggctatgc agcccccgcc agctgccctc aaatcccgtc   1985

 caggccagtt ccagattcta aactgatttt tttcatgata ttgtcaaaac agtgaggaaa   2045

 cattaaaaaa aaa                                                      2058




      <210> 228
      <211> 1684
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (89)..(1684)

      <400> 228
 cagccggggc agcaagagcg agatctcatt ttggaatcta tcaaacaagc aaaaaatcaa     60

 aacaaaaagc tagcttgaat tgaaaggg   atg gag aga atc ctg ttt gac cct     112
                                  Met Glu Arg Ile Leu Phe Asp Pro
                                    1               5

 caa aat tct aca gtc agg aaa cag gct gat gaa act act cag ctg cca      160
 Gln Asn Ser Thr Val Arg Lys Gln Ala Asp Glu Thr Thr Gln Leu Pro
      10                  15                  20

 aca cat gct acc ctt cag gaa aaa gga aag aca gct ttg agg gta tta      208
 Thr His Ala Thr Leu Gln Glu Lys Gly Lys Thr Ala Leu Arg Val Leu
  25                  30                  35                  40

 tac ctg aag aac ctt agc cct cgg gtg act gaa aga gat ctt gtg tca      256
 Tyr Leu Lys Asn Leu Ser Pro Arg Val Thr Glu Arg Asp Leu Val Ser
                  45                  50                  55

 ttg ttc gct cgg ttc cag gag aaa aaa gga cct cca att caa ttc cga      304
 Leu Phe Ala Arg Phe Gln Glu Lys Lys Gly Pro Pro Ile Gln Phe Arg
              60                  65                  70

 atg atg act gga cga atg agg ggc cag gct ttt atc acc ttt ccc aat      352
 Met Met Thr Gly Arg Met Arg Gly Gln Ala Phe Ile Thr Phe Pro Asn
          75                  80                  85

 aag gag ata gca tgg caa gca ttg cat cta gta aat gga tac aaa cta      400
 Lys Glu Ile Ala Trp Gln Ala Leu His Leu Val Asn Gly Tyr Lys Leu
      90                  95                 100

 cat ggg aaa ata ttg gtg ata gag ttt gga aag aac aaa aag caa cgg      448
 His Gly Lys Ile Leu Val Ile Glu Phe Gly Lys Asn Lys Lys Gln Arg
 105                 110                 115                 120

 tca aat ctc caa gcg act tct ctc ata tca tgt gct aca gtt ctg gaa      496
 Ser Asn Leu Gln Ala Thr Ser Leu Ile Ser Cys Ala Thr Val Leu Glu
                 125                 130                 135

 act aga agt cca aga tca agg tgt tgg cag gtt cag tgt ctg gtg aag      544
 Thr Arg Ser Pro Arg Ser Arg Cys Trp Gln Val Gln Cys Leu Val Lys
             140                 145                 150

 gct att ctc ccc ttc caa gat gat act ttg ttg cta cat cct cca gag      592
 Ala Ile Leu Pro Phe Gln Asp Asp Thr Leu Leu Leu His Pro Pro Glu
         155                 160                 165

 ggg aag aac gct gct ccc ttt tat ggc gga ggg aaa atg att aat cct      640
 Gly Lys Asn Ala Ala Pro Phe Tyr Gly Gly Gly Lys Met Ile Asn Pro
     170                 175                 180

 agt tgt cct gga gga ctt gga gcc act gtc tgt tgg act tac ttc acc      688
 Ser Cys Pro Gly Gly Leu Gly Ala Thr Val Cys Trp Thr Tyr Phe Thr
 185                 190                 195                 200

 cat acc agt atg tct gat ggg ggt gga att caa gtg ccc cct atg acc      736
 His Thr Ser Met Ser Asp Gly Gly Gly Ile Gln Val Pro Pro Met Thr
                 205                 210                 215

 atc tac act gaa caa gat tta tac aat cat gtc gta cct aag ccc cac      784
 Ile Tyr Thr Glu Gln Asp Leu Tyr Asn His Val Val Pro Lys Pro His
             220                 225                 230

 aac aaa aga gta ccc att ctt cct ttt gtt atc aga gca gga gtg cta      832
 Asn Lys Arg Val Pro Ile Leu Pro Phe Val Ile Arg Ala Gly Val Leu
         235                 240                 245

 ggc aga cta ggt act ggc att ggc agt atc aca acc tct act cag ttc      880
 Gly Arg Leu Gly Thr Gly Ile Gly Ser Ile Thr Thr Ser Thr Gln Phe
     250                 255                 260

 tac tac aaa cta tct caa gaa ata aat ggt gac atg gaa cag gtc act      928
 Tyr Tyr Lys Leu Ser Gln Glu Ile Asn Gly Asp Met Glu Gln Val Thr
 265                 270                 275                 280

 gac tcc ctg gtc acc ttg caa gat caa ctt aac tcc cta gca gca gta      976
 Asp Ser Leu Val Thr Leu Gln Asp Gln Leu Asn Ser Leu Ala Ala Val
                 285                 290                 295

 gtc ctt caa aat cga aga gct tta gac ttg cta acc gcc aaa aga ggg     1024
 Val Leu Gln Asn Arg Arg Ala Leu Asp Leu Leu Thr Ala Lys Arg Gly
             300                 305                 310

 gga acc tgt tta ttt tta gga gaa gaa tgc tgt tat tat gtt aat caa     1072
 Gly Thr Cys Leu Phe Leu Gly Glu Glu Cys Cys Tyr Tyr Val Asn Gln
         315                 320                 325

 tcc aga att gtc act gag aaa gtt aaa gaa att cga gat cga ata caa     1120
 Ser Arg Ile Val Thr Glu Lys Val Lys Glu Ile Arg Asp Arg Ile Gln
     330                 335                 340

 tgt aga gca gag gag ctt caa aac acc gaa cac tgg ggc ctc ctc agc     1168
 Cys Arg Ala Glu Glu Leu Gln Asn Thr Glu His Trp Gly Leu Leu Ser
 345                 350                 355                 360

 caa tgg atg ccc tgg gtt ctc ccc ttc tta gga cct cta gca gct cta     1216
 Gln Trp Met Pro Trp Val Leu Pro Phe Leu Gly Pro Leu Ala Ala Leu
                 365                 370                 375

 ata ttg tta ctc ctc ttt gga ccc tgt atc ttt aac ctc ctt gtt aag     1264
 Ile Leu Leu Leu Leu Phe Gly Pro Cys Ile Phe Asn Leu Leu Val Lys
             380                 385                 390

 ttt gtc tct tcc aga att gaa gct gta aag cta caa atg gtt ctt caa     1312
 Phe Val Ser Ser Arg Ile Glu Ala Val Lys Leu Gln Met Val Leu Gln
         395                 400                 405

 atg gag ccc cag atg cag tcc atg act aaa atc tac cac gga ccc ctg     1360
 Met Glu Pro Gln Met Gln Ser Met Thr Lys Ile Tyr His Gly Pro Leu
     410                 415                 420

 gac cag cct gct agc cct tgt tcc gat gtt aat gac atc aaa ggc acc     1408
 Asp Gln Pro Ala Ser Pro Cys Ser Asp Val Asn Asp Ile Lys Gly Thr
 425                 430                 435                 440

 cct cct gag gaa atc tca act gca caa ccc cta cca tgc ccc att tca     1456
 Pro Pro Glu Glu Ile Ser Thr Ala Gln Pro Leu Pro Cys Pro Ile Ser
                 445                 450                 455

 gca gga agc agg aag gaa gag tat gtg tat gtg gtc tta cta gca ttt     1504
 Ala Gly Ser Arg Lys Glu Glu Tyr Val Tyr Val Val Leu Leu Ala Phe
             460                 465                 470

 cct gag ggt att att ttg caa gcc tta gga aat acc aga aaa gga aag     1552
 Pro Glu Gly Ile Ile Leu Gln Ala Leu Gly Asn Thr Arg Lys Gly Lys
         475                 480                 485

 gga gaa agt gga gta cat gga cat agc ttt cct ccc ttc tgg agt atg     1600
 Gly Glu Ser Gly Val His Gly His Ser Phe Pro Pro Phe Trp Ser Met
     490                 495                 500

 gaa caa gaa gaa gat acc agg ccc tca cca gac acc aaa tct gct ggt     1648
 Glu Gln Glu Glu Asp Thr Arg Pro Ser Pro Asp Thr Lys Ser Ala Gly
 505                 510                 515                 520

 atc ttg atc tcg gca tcc cag ccg cta aac atg tga                     1684
 Ile Leu Ile Ser Ala Ser Gln Pro Leu Asn Met 
                 525                 530





      <210> 229
      <211> 962
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (220)..(894)

      <400> 229
 cggtcactct acctttccaa ggagggacag tgccctagag cccatttgag aatttgatgc     60

 caaaggaagg ggaaattttg attcactacc gtttagaggc ccactggatt ggccagcccc    120

 caggttccgg tggcttctaa tgttttgggg ttgatgccgc acttagggga gtgatattta    180

 ccttgattgg tatcattaac tattgtggca ttcaaaatt   atg gat tta aaa cat     234
                                              Met Asp Leu Lys His
                                                1               5

 tta gcc aga aga gaa acc ctg atg ccc tta tca atg aag cta cta ggc      282
 Leu Ala Arg Arg Glu Thr Leu Met Pro Leu Ser Met Lys Leu Leu Gly
                  10                  15                  20

 aag ttg ctt tgg cag atg cca ttc tca tta ata aaa cag act ttg gtt      330
 Lys Leu Leu Trp Gln Met Pro Phe Ser Leu Ile Lys Gln Thr Leu Val
              25                  30                  35

 cca gaa gaa gat gta aag aaa tta aga gcg aca att aga tcc ata aat      378
 Pro Glu Glu Asp Val Lys Lys Leu Arg Ala Thr Ile Arg Ser Ile Asn
          40                  45                  50

 gga cta gga caa atc tta gaa aca caa aga tca aga gtt gat ctc tct      426
 Gly Leu Gly Gln Ile Leu Glu Thr Gln Arg Ser Arg Val Asp Leu Ser
      55                  60                  65

 aat gta tta gat ctt cat gcc ttt gat agt ctc tct gga ata agt ttg      474
 Asn Val Leu Asp Leu His Ala Phe Asp Ser Leu Ser Gly Ile Ser Leu
  70                  75                  80                  85

 cag aaa aaa ctt cag cat gtg cca gga aca caa cct cac ctt gat cag      522
 Gln Lys Lys Leu Gln His Val Pro Gly Thr Gln Pro His Leu Asp Gln
                  90                  95                 100

 agt att gtt aca atc aca ttt gaa gta cca gga aat gca aag gaa gaa      570
 Ser Ile Val Thr Ile Thr Phe Glu Val Pro Gly Asn Ala Lys Glu Glu
             105                 110                 115

 cat ctt aat atg ttt att cag aat ctc ctg tgg gaa aag aat gtg aga      618
 His Leu Asn Met Phe Ile Gln Asn Leu Leu Trp Glu Lys Asn Val Arg
         120                 125                 130

 aac aag gac aat cac tgc atg gag gtc ata agg ctg aag gga ttg gtg      666
 Asn Lys Asp Asn His Cys Met Glu Val Ile Arg Leu Lys Gly Leu Val
     135                 140                 145

 tca atc aaa gac aaa tca caa caa gtg att gtc cag ggt gtc cat gag      714
 Ser Ile Lys Asp Lys Ser Gln Gln Val Ile Val Gln Gly Val His Glu
 150                 155                 160                 165

 ctc tat gat ctg gag gag act cca gtg agc tgg aag gat gac act gag      762
 Leu Tyr Asp Leu Glu Glu Thr Pro Val Ser Trp Lys Asp Asp Thr Glu
                 170                 175                 180

 aga aca aat cga ttg gtc ctc ctt ggc aga aat tta gat aag gat atc      810
 Arg Thr Asn Arg Leu Val Leu Leu Gly Arg Asn Leu Asp Lys Asp Ile
             185                 190                 195

 ctt aaa cag ctg ttt ata gct act gtg aca gaa aca gaa aag cag tgg      858
 Leu Lys Gln Leu Phe Ile Ala Thr Val Thr Glu Thr Glu Lys Gln Trp
         200                 205                 210

 aca aca cat ttc aaa gaa gat caa gtt tgt aca taa cact agaggcattt      908
 Thr Thr His Phe Lys Glu Asp Gln Val Cys Thr 
     215                 220

 cttatcaaaa ggattggata ataaaaataa gtttctactg ggaaaaaaaa aaaa          962




      <210> 230
      <211> 718
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (118)..(657)

      <400> 230
 gggggtgggg gcgggtggtt gcctgcggga ggccgccgcg ggtcatgtga ccggaagggc     60

 tcctcacgga cgccgtccct cctcggcgcg gcctgagcgc ccggcccgac cccggcc       117                                                                 
 atg ggg tgc tgc tac agc agc gag aac gag gac tcg gac cag gac cga      165
 Met Gly Cys Cys Tyr Ser Ser Glu Asn Glu Asp Ser Asp Gln Asp Arg
   1               5                  10                  15

 gag gag cgg aag ctg ctg ctg gac cct agc agc ccc cct acc aaa gct      213
 Glu Glu Arg Lys Leu Leu Leu Asp Pro Ser Ser Pro Pro Thr Lys Ala
              20                  25                  30

 ctc aat gga gcc gag ccc aac tac cac agc ctg cct tcc gct cgc act      261
 Leu Asn Gly Ala Glu Pro Asn Tyr His Ser Leu Pro Ser Ala Arg Thr
          35                  40                  45

 gat gag cag gcc ctg ctc tct tcc atc ctt gcc aag aca gcc agc aac      309
 Asp Glu Gln Ala Leu Leu Ser Ser Ile Leu Ala Lys Thr Ala Ser Asn
      50                  55                  60

 atc att gat gtg tct gct gca gac tca cag ggc atg gag cag cat gag      357
 Ile Ile Asp Val Ser Ala Ala Asp Ser Gln Gly Met Glu Gln His Glu
  65                  70                  75                  80

 tac atg gac cgt gcc agg cag tac agc acc cgc ttg gct gtg ctg agc      405
 Tyr Met Asp Arg Ala Arg Gln Tyr Ser Thr Arg Leu Ala Val Leu Ser
                  85                  90                  95

 agc agc ctg acc cat tgg aag aag ctg cca ccg ctg ccg tct ctt acc      453
 Ser Ser Leu Thr His Trp Lys Lys Leu Pro Pro Leu Pro Ser Leu Thr
             100                 105                 110

 agc cag ccc cac caa gtg ctg gcc agt gag ccc atc ccg ttc tct gat      501
 Ser Gln Pro His Gln Val Leu Ala Ser Glu Pro Ile Pro Phe Ser Asp
         115                 120                 125

 ttg cag cag gtc tcc agg ata gct gct tat gcc tac agt gca ctt tct      549
 Leu Gln Gln Val Ser Arg Ile Ala Ala Tyr Ala Tyr Ser Ala Leu Ser
     130                 135                 140

 cag atc cgt gtg gac gca aaa gag gag ctg gtt gta cag ttt ggg gat      597
 Gln Ile Arg Val Asp Ala Lys Glu Glu Leu Val Val Gln Phe Gly Asp
 145                 150                 155                 160

 ccc atg aag aaa agg ggc cct ggg aaa gct cct ctt cct ctc ctc tca      645
 Pro Met Lys Lys Arg Gly Pro Gly Lys Ala Pro Leu Pro Leu Leu Ser
                 165                 170                 175

 ccc cat ttt taa ccc aacccccttg ggccccagcc tctattgggg gttttacagg      700
 Pro His Phe 


 tacctcaacc cgaaggac                                                  718




      <210> 231
      <211> 3280
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2892)

      <400> 231
  atg gac gcc cca aaa gca gga tac gcc ttt gag tac ctt att gaa aca      48
  Met Asp Ala Pro Lys Ala Gly Tyr Ala Phe Glu Tyr Leu Ile Glu Thr
    1               5                  10                  15

 tta aat gac agt tca cat aag aag ttc ttc gat gta tct aaa ctt ggc       96
 Leu Asn Asp Ser Ser His Lys Lys Phe Phe Asp Val Ser Lys Leu Gly
              20                  25                  30

 acc aag tat gat gtt ctg cct tac tca ata cgg gtc ttg ttg gaa gct      144
 Thr Lys Tyr Asp Val Leu Pro Tyr Ser Ile Arg Val Leu Leu Glu Ala
          35                  40                  45

 gct gta cga aat tgt gat ggc ttt tta atg aag aag gaa gat gtt atg      192
 Ala Val Arg Asn Cys Asp Gly Phe Leu Met Lys Lys Glu Asp Val Met
      50                  55                  60

 aac att tta gac tgg aaa acc aaa caa agc aat gtt gaa gtg ccc ttt      240
 Asn Ile Leu Asp Trp Lys Thr Lys Gln Ser Asn Val Glu Val Pro Phe
  65                  70                  75                  80

 ttc cct gcc cgt gtt ctt ctt caa gat ttt act gga ata cca gca atg      288
 Phe Pro Ala Arg Val Leu Leu Gln Asp Phe Thr Gly Ile Pro Ala Met
                  85                  90                  95

 gtg gat ttt gct gct atg agg gag gca gtg aaa act ctt gga ggt gat      336
 Val Asp Phe Ala Ala Met Arg Glu Ala Val Lys Thr Leu Gly Gly Asp
             100                 105                 110

 cct gag aaa gtc cat cct gct tgt ccg aca gat ctt aca gtt gac cat      384
 Pro Glu Lys Val His Pro Ala Cys Pro Thr Asp Leu Thr Val Asp His
         115                 120                 125

 tct tta caa att gac ttc agt aaa tgt gca ata cag aat gca cca aat      432
 Ser Leu Gln Ile Asp Phe Ser Lys Cys Ala Ile Gln Asn Ala Pro Asn
     130                 135                 140

 cct gga ggt ggt gac ctg cag aaa gca gga aag ctc tct cca ctt aaa      480
 Pro Gly Gly Gly Asp Leu Gln Lys Ala Gly Lys Leu Ser Pro Leu Lys
 145                 150                 155                 160

 gtg cag cct aag aag ctt ccc tgc aga ggc cag act acc tgc cga gga      528
 Val Gln Pro Lys Lys Leu Pro Cys Arg Gly Gln Thr Thr Cys Arg Gly
                 165                 170                 175

 tct tgt gat tct gga gaa cta ggc cga aac tca gga aca ttt tct tcg      576
 Ser Cys Asp Ser Gly Glu Leu Gly Arg Asn Ser Gly Thr Phe Ser Ser
             180                 185                 190

 cag att gag aat aca ccc atc ctg tgt cct ttt cat ttg caa cca gtg      624
 Gln Ile Glu Asn Thr Pro Ile Leu Cys Pro Phe His Leu Gln Pro Val
         195                 200                 205

 cct gaa cct gaa aca gtg tta aaa aat caa gaa gta gaa ttc ggc aga      672
 Pro Glu Pro Glu Thr Val Leu Lys Asn Gln Glu Val Glu Phe Gly Arg
     210                 215                 220

 aat cga gag agg ctt cag ttt ttt aag tgg agt tca aga gtt tta aag      720
 Asn Arg Glu Arg Leu Gln Phe Phe Lys Trp Ser Ser Arg Val Leu Lys
 225                 230                 235                 240

 aat gtg gca gtg atc cct cct gga act gga atg gct cat caa ata aac      768
 Asn Val Ala Val Ile Pro Pro Gly Thr Gly Met Ala His Gln Ile Asn
                 245                 250                 255

 tta gaa tat ttg tca aga gtg gtt ttt gaa gaa aaa gac ctc ctc ttc      816
 Leu Glu Tyr Leu Ser Arg Val Val Phe Glu Glu Lys Asp Leu Leu Phe
             260                 265                 270

 cca gac agt gta gtc ggc aca gat tca cac ata acg atg gtg aat ggt      864
 Pro Asp Ser Val Val Gly Thr Asp Ser His Ile Thr Met Val Asn Gly
         275                 280                 285

 tta ggg att ctg ggg tgg ggg gtt gga ggc att gaa aca gaa gca gtt      912
 Leu Gly Ile Leu Gly Trp Gly Val Gly Gly Ile Glu Thr Glu Ala Val
     290                 295                 300

 atg ctt ggt ctg cca gtt tct ctt act tta cca gag gtg gtt gga tgt      960
 Met Leu Gly Leu Pro Val Ser Leu Thr Leu Pro Glu Val Val Gly Cys
 305                 310                 315                 320

 gag tta act ggg tca tca aac cct ttt gtt aca tcc ata gat gtt gtt     1008
 Glu Leu Thr Gly Ser Ser Asn Pro Phe Val Thr Ser Ile Asp Val Val
                 325                 330                 335

 ctt ggt att aca aag cac ctc agg caa gta gga gtg gct gga aag ttt     1056
 Leu Gly Ile Thr Lys His Leu Arg Gln Val Gly Val Ala Gly Lys Phe
             340                 345                 350

 gtt gag ttt ttt gga agt gga gtt tca caa tta tct ata gtt gat cga     1104
 Val Glu Phe Phe Gly Ser Gly Val Ser Gln Leu Ser Ile Val Asp Arg
         355                 360                 365

 act aca ata gca aac atg tgt ccg gaa tat ggt gct atc ctc agc ttt     1152
 Thr Thr Ile Ala Asn Met Cys Pro Glu Tyr Gly Ala Ile Leu Ser Phe
     370                 375                 380

 ttc cct gtt gac aat gtg aca tta aaa cat tta gaa cat aca ggt ttt     1200
 Phe Pro Val Asp Asn Val Thr Leu Lys His Leu Glu His Thr Gly Phe
 385                 390                 395                 400

 agc aaa gcc aaa ctc gaa tca atg gaa aca tac ctt aaa gct gtg aaa     1248
 Ser Lys Ala Lys Leu Glu Ser Met Glu Thr Tyr Leu Lys Ala Val Lys
                 405                 410                 415

 ttg ttt cga aat gac cag aat tct tca gga gaa cct gaa tac tcc cag     1296
 Leu Phe Arg Asn Asp Gln Asn Ser Ser Gly Glu Pro Glu Tyr Ser Gln
             420                 425                 430

 gtg atc cag att aat ctg aat tca ata gtt cca tct gtt agt ggt cca     1344
 Val Ile Gln Ile Asn Leu Asn Ser Ile Val Pro Ser Val Ser Gly Pro
         435                 440                 445

 aaa aga cct cgg gat aga gtt gct gtg aca gat atg aaa agc gat ttc     1392
 Lys Arg Pro Arg Asp Arg Val Ala Val Thr Asp Met Lys Ser Asp Phe
     450                 455                 460

 cag gct tgc tta aat gaa aag gtt gga ttt aaa ggc ttc caa att gca     1440
 Gln Ala Cys Leu Asn Glu Lys Val Gly Phe Lys Gly Phe Gln Ile Ala
 465                 470                 475                 480

 gct gaa aaa caa aag gat att gtc tcc att cat tat gaa gga agt gaa     1488
 Ala Glu Lys Gln Lys Asp Ile Val Ser Ile His Tyr Glu Gly Ser Glu
                 485                 490                 495

 tat aag ctg tct cat gga tca gtg gtc att gct gca gtt atc agt tgt     1536
 Tyr Lys Leu Ser His Gly Ser Val Val Ile Ala Ala Val Ile Ser Cys
             500                 505                 510

 acc aat aat tgc aat cca tct gtc atg ctt gct gca ggt ctt ttg gct     1584
 Thr Asn Asn Cys Asn Pro Ser Val Met Leu Ala Ala Gly Leu Leu Ala
         515                 520                 525

 aaa aag gct gtt gaa gct ggt ctg cgt gtt aaa cct tat ata aga aca     1632
 Lys Lys Ala Val Glu Ala Gly Leu Arg Val Lys Pro Tyr Ile Arg Thr
     530                 535                 540

 agt tta tct cca ggc agt ggg atg gtt aca cat tac ctc agt tca agt     1680
 Ser Leu Ser Pro Gly Ser Gly Met Val Thr His Tyr Leu Ser Ser Ser
 545                 550                 555                 560

 gga gta tta cca tat cta agt aag ctt gga ttt gaa atc gtt ggc tat     1728
 Gly Val Leu Pro Tyr Leu Ser Lys Leu Gly Phe Glu Ile Val Gly Tyr
                 565                 570                 575

 gga tgt tca act tgt gtg gga aat aca gca ccc tta tca gac gca gtt     1776
 Gly Cys Ser Thr Cys Val Gly Asn Thr Ala Pro Leu Ser Asp Ala Val
             580                 585                 590

 tta aat gca gta aaa cag ggt gat ttg gtt acc tgt ggt aat ttt atc     1824
 Leu Asn Ala Val Lys Gln Gly Asp Leu Val Thr Cys Gly Asn Phe Ile
         595                 600                 605

 tgg aaa aaa aat ttt gaa ggt cgt ctt tgt gat tgt gtt cgt gcc aat     1872
 Trp Lys Lys Asn Phe Glu Gly Arg Leu Cys Asp Cys Val Arg Ala Asn
     610                 615                 620

 tat ctt gcc tct cca ccc tta gtg gta gct tat gcc ata gca ggc aca     1920
 Tyr Leu Ala Ser Pro Pro Leu Val Val Ala Tyr Ala Ile Ala Gly Thr
 625                 630                 635                 640

 gtg aat ata gat ttc cag aca gaa cct tta ggt act gac ccc acc ggc     1968
 Val Asn Ile Asp Phe Gln Thr Glu Pro Leu Gly Thr Asp Pro Thr Gly
                 645                 650                 655

 aag aac att tac ctg cat gat att tgg cct agt cga gaa gaa gtt cat     2016
 Lys Asn Ile Tyr Leu His Asp Ile Trp Pro Ser Arg Glu Glu Val His
             660                 665                 670

 cga gta gag gaa gaa cat gtt ata cta tcc atg ttt aaa gca tta aaa     2064
 Arg Val Glu Glu Glu His Val Ile Leu Ser Met Phe Lys Ala Leu Lys
         675                 680                 685

 gat aaa ata gaa atg ggg aat aaa cgg tgg aat tcc tta gaa gca ccg     2112
 Asp Lys Ile Glu Met Gly Asn Lys Arg Trp Asn Ser Leu Glu Ala Pro
     690                 695                 700

 gat tca gtt ttg ttt cca tgg gac tta aag tct act tat atc aga tgc     2160
 Asp Ser Val Leu Phe Pro Trp Asp Leu Lys Ser Thr Tyr Ile Arg Cys
 705                 710                 715                 720

 cct tca ttt ttt gat aaa ctt acc aaa gag cca att gca ctc cag gct     2208
 Pro Ser Phe Phe Asp Lys Leu Thr Lys Glu Pro Ile Ala Leu Gln Ala
                 725                 730                 735

 att gaa aat gcc cat gtc tta tta tat ttg gga gac tct gtc aca aca     2256
 Ile Glu Asn Ala His Val Leu Leu Tyr Leu Gly Asp Ser Val Thr Thr
             740                 745                 750

 gat cat ata tca cct gca gga agt atc gct agg aat agt gct gcc gct     2304
 Asp His Ile Ser Pro Ala Gly Ser Ile Ala Arg Asn Ser Ala Ala Ala
         755                 760                 765

 aag tat ttg aca aac aga ggc ctt acc cct cgt gaa ttc aac tct tac     2352
 Lys Tyr Leu Thr Asn Arg Gly Leu Thr Pro Arg Glu Phe Asn Ser Tyr
     770                 775                 780

 gga gct cga aga ggt aat gat gct gta atg aca aga ggc act ttt gca     2400
 Gly Ala Arg Arg Gly Asn Asp Ala Val Met Thr Arg Gly Thr Phe Ala
 785                 790                 795                 800

 aat atc aag ctt ttt aat aag ttt att gga aaa cca gct cct aaa aca     2448
 Asn Ile Lys Leu Phe Asn Lys Phe Ile Gly Lys Pro Ala Pro Lys Thr
                 805                 810                 815

 att cat ttt cca tca gga cag acg cta gat gta ttt gag gct gca gag     2496
 Ile His Phe Pro Ser Gly Gln Thr Leu Asp Val Phe Glu Ala Ala Glu
             820                 825                 830

 ctg tac cag aaa gaa ggt atc cca ctg att att tta gca gga aag aaa     2544
 Leu Tyr Gln Lys Glu Gly Ile Pro Leu Ile Ile Leu Ala Gly Lys Lys
         835                 840                 845

 tat ggt tca gga aac tcc aga gac tgg gct gcc aaa gga ccg tat tta     2592
 Tyr Gly Ser Gly Asn Ser Arg Asp Trp Ala Ala Lys Gly Pro Tyr Leu
     850                 855                 860

 ctg ggt gtg aaa gct gtt ttg gcc gaa agt tat gaa aaa ata cac aaa     2640
 Leu Gly Val Lys Ala Val Leu Ala Glu Ser Tyr Glu Lys Ile His Lys
 865                 870                 875                 880

 gat cat ttg att gga att ggc ata gct cca ctt cag ttc ctt cca gga     2688
 Asp His Leu Ile Gly Ile Gly Ile Ala Pro Leu Gln Phe Leu Pro Gly
                 885                 890                 895

 gaa aat gca gat tcc ttg ggc ctc tcc ggt aga gaa aca ttt tct tta     2736
 Glu Asn Ala Asp Ser Leu Gly Leu Ser Gly Arg Glu Thr Phe Ser Leu
             900                 905                 910

 aca ttt cct gaa gaa ctg tct cct gga att aca ttg aat ata cag aca     2784
 Thr Phe Pro Glu Glu Leu Ser Pro Gly Ile Thr Leu Asn Ile Gln Thr
         915                 920                 925

 agc act gga aaa gta ttc agc gtg att gct tcg ttt gaa gat gat gtg     2832
 Ser Thr Gly Lys Val Phe Ser Val Ile Ala Ser Phe Glu Asp Asp Val
     930                 935                 940

 gaa ata aca tta tac aaa cat gga gga tta tta aac ttt gtg gca cga     2880
 Glu Ile Thr Leu Tyr Lys His Gly Gly Leu Leu Asn Phe Val Ala Arg
 945                 950                 955                 960

 aaa ttc tca tag tat ctacttacca tagatacctt tcataactgg taactgcaaa     2935
 Lys Phe Ser 


 gccttttgtg ctggacccag gaatccttac catggagcag cagatagtcc cagtatactc   2995

 acttatctca tccatggatg taaatgatga tgaatcaaca tagtaactga aatgaaatct   3055

 tcttgatttt aaataatata cgaatggtgc tattaatatt gctaaaatca acgtgtgaag   3115

 tgtgttgtgg aagagacctg taagtatggg ggggggcgat attttatcag accattttgt   3175

 aaataaaggc agaatttgtg ttgaagattc ttatatgaat aaccttcctg gatttgttta   3235

 gttttgcacc aataaaactg tgtactactg ttaaaaaaaa aaaaa                   3280




      <210> 232
      <211> 475
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (39)..(461)

      <400> 232
 cggcacgagg tgttcactag caacctcaaa cagacacc    atg gtg cac ctg act      53
                                              Met Val His Leu Thr
                                                1               5

 cct gag gag aag tct gcc gtt act gcc ctg tgg ggc aag gtg aac gtg      101
 Pro Glu Glu Lys Ser Ala Val Thr Ala Leu Trp Gly Lys Val Asn Val
                  10                  15                  20

 gat gaa gtt ggt ggt gag gcc ctg ggc agg ctg ctg gtg gtc tac cct      149
 Asp Glu Val Gly Gly Glu Ala Leu Gly Arg Leu Leu Val Val Tyr Pro
              25                  30                  35

 tgg acc cag agg ttc ttt gag tcc ttt ggg gat ctg tcc act cct gat      197
 Trp Thr Gln Arg Phe Phe Glu Ser Phe Gly Asp Leu Ser Thr Pro Asp
          40                  45                  50

 gct gtt atg ggc aac cct aag gtg aag gct cat ggc aag aaa gtg ctc      245
 Ala Val Met Gly Asn Pro Lys Val Lys Ala His Gly Lys Lys Val Leu
      55                  60                  65

 ggt gcc ttt agt gat ggc ctg gct cac ctg gac aac ctc aag ggc acc      293
 Gly Ala Phe Ser Asp Gly Leu Ala His Leu Asp Asn Leu Lys Gly Thr
  70                  75                  80                  85

 ttt gcc aca ctg agt gag ctg cac tgt gac aag ctg cac gtg gat cct      341
 Phe Ala Thr Leu Ser Glu Leu His Cys Asp Lys Leu His Val Asp Pro
                  90                  95                 100

 gag aac ttc agg ctc ctg ggg caa cgt gct ggt ctg tgt gct ggg ccc      389
 Glu Asn Phe Arg Leu Leu Gly Gln Arg Ala Gly Leu Cys Ala Gly Pro
             105                 110                 115

 atc act ttg ggc aaa gaa ttt cac ccc acc agt gca ggc tgc cta tca      437
 Ile Thr Leu Gly Lys Glu Phe His Pro Thr Ser Ala Gly Cys Leu Ser
         120                 125                 130

 gaa agt ggt ggg tgg tgt ggc taa tgccctggcc caaa                      475
 Glu Ser Gly Gly Trp Cys Gly 
     135                 140





      <210> 233
      <211> 804
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (269)..(691)

      <400> 233
 attttctctg gtgttttcac tagttccggc ctttggcgct ctatgacgtc accgaagtga     60

 cggagcggaa aagcgcgaga agcggcttgg ttccttgtac gcagaggcgg tagtgacaca    120

 ggcacaactg acagtggcag aagctcagct gacaaggact ggggacggcg gtgtccttgt    180

 cttgcctttg tcgcccccgc ccctctcttc cctggctgga cttgcggagt ccccgccgaa    240

 gaacccgagg agccatatat tgaagacc   atg tct gga agc ttc tac ttt gta     292
                                  Met Ser Gly Ser Phe Tyr Phe Val
                                    1               5

 att gtt ggt cac cat gat aat cca gtt ttt gaa atg gag ttt ttg cca      340
 Ile Val Gly His His Asp Asn Pro Val Phe Glu Met Glu Phe Leu Pro
      10                  15                  20

 gct ggg aag gca gaa tcc aaa gac gac cat cgt cat ctg aac cag ttc      388
 Ala Gly Lys Ala Glu Ser Lys Asp Asp His Arg His Leu Asn Gln Phe
  25                  30                  35                  40

 ata gct cat gct gct ctc gac ctc gta gat gag aac atg tgg ctg tcg      436
 Ile Ala His Ala Ala Leu Asp Leu Val Asp Glu Asn Met Trp Leu Ser
                  45                  50                  55

 aac aac atg tac ttg aaa act gtg gac aag ttc aac gag tgg ttt gtg      484
 Asn Asn Met Tyr Leu Lys Thr Val Asp Lys Phe Asn Glu Trp Phe Val
              60                  65                  70

 tca gca ttt gtc acc gcg ggg cat atg agg ttt att atg ctt cat gac      532
 Ser Ala Phe Val Thr Ala Gly His Met Arg Phe Ile Met Leu His Asp
          75                  80                  85

 ata aga caa gaa gat gga ata aag aac ttc ttt act gat gtt tat gat      580
 Ile Arg Gln Glu Asp Gly Ile Lys Asn Phe Phe Thr Asp Val Tyr Asp
      90                  95                 100

 tta tat ata aaa ttt tca atg aat cca ttt tat gaa ccc aat tct cct      628
 Leu Tyr Ile Lys Phe Ser Met Asn Pro Phe Tyr Glu Pro Asn Ser Pro
 105                 110                 115                 120

 att cga tca agt gca ttt gac aga aaa gtt cag ttt ctt ggg aag aaa      676
 Ile Arg Ser Ser Ala Phe Asp Arg Lys Val Gln Phe Leu Gly Lys Lys
                 125                 130                 135

 cac ctt tta agc tga atggagaaaa ttccaaaata aattatatca ccacaatggt      731
 His Leu Leu Ser 
             140

 gtatactcag gaatgtgtac attgtaaatt acttgattaa atagcctgga aatcttttgt    791

 gtaaaaaaaa aaa                                                       804




      <210> 234
      <211> 763
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(711)

      <400> 234
  atg agg ctg gcg ggc cag gtt agg cag ggc ccc ggg gac ttt gtg caa      48
  Met Arg Leu Ala Gly Gln Val Arg Gln Gly Pro Gly Asp Phe Val Gln
    1               5                  10                  15

 ctg cct gtg ccc gtc atc cag cag ctc tac cac tgg gac tgt ggc ctg       96
 Leu Pro Val Pro Val Ile Gln Gln Leu Tyr His Trp Asp Cys Gly Leu
              20                  25                  30

 gcc tgc tcc agg atg gtg ctg cgg tac ctg ggc cag ctg gac gac agt      144
 Ala Cys Ser Arg Met Val Leu Arg Tyr Leu Gly Gln Leu Asp Asp Ser
          35                  40                  45

 gag ttt gag aga gcc ctg cag aag ctg cag ctg acc agg agc atc tgg      192
 Glu Phe Glu Arg Ala Leu Gln Lys Leu Gln Leu Thr Arg Ser Ile Trp
      50                  55                  60

 acc atc gac ctg gcc tac ctg atg cac cac ttt ggc gtg agg cac cgc      240
 Thr Ile Asp Leu Ala Tyr Leu Met His His Phe Gly Val Arg His Arg
  65                  70                  75                  80

 ttc tgt acc cag acc ctg ggt gtc gac aag ggc tac aag aac cag tcc      288
 Phe Cys Thr Gln Thr Leu Gly Val Asp Lys Gly Tyr Lys Asn Gln Ser
                  85                  90                  95

 ttc tac agg aag cac ttt gac aca gaa gag acc cgg gtg aat cag ctg      336
 Phe Tyr Arg Lys His Phe Asp Thr Glu Glu Thr Arg Val Asn Gln Leu
             100                 105                 110

 ttt gca caa gca aag gcc tgc aag gtg ctg gtg gag aaa tgc aca gtg      384
 Phe Ala Gln Ala Lys Ala Cys Lys Val Leu Val Glu Lys Cys Thr Val
         115                 120                 125

 agt gtg aag gac atc cag gcg cac ctg gct cag ggc cat gtg gcc atc      432
 Ser Val Lys Asp Ile Gln Ala His Leu Ala Gln Gly His Val Ala Ile
     130                 135                 140

 gtg ctg gtg aac tcg ggg gtg ctg cac tgt gac ctg tgc tcc agc cct      480
 Val Leu Val Asn Ser Gly Val Leu His Cys Asp Leu Cys Ser Ser Pro
 145                 150                 155                 160

 gtc aag tac tgc tgc ttc acc ccc agt ggc cac cac tgc ttc tgc cgc      528
 Val Lys Tyr Cys Cys Phe Thr Pro Ser Gly His His Cys Phe Cys Arg
                 165                 170                 175

 act cct gac tac cag ggc cac ttc atc gtg ctg cgt ggc tac aac cgg      576
 Thr Pro Asp Tyr Gln Gly His Phe Ile Val Leu Arg Gly Tyr Asn Arg
             180                 185                 190

 gcc act ggc tgc atc ttc tac aac aac cca gcc tat gcc gac cga atg      624
 Ala Thr Gly Cys Ile Phe Tyr Asn Asn Pro Ala Tyr Ala Asp Arg Met
         195                 200                 205

 tgc agc acc agc atc agt aac ttt gag gag gcc aga acc agc tat ggc      672
 Cys Ser Thr Ser Ile Ser Asn Phe Glu Glu Ala Arg Thr Ser Tyr Gly
     210                 215                 220

 aca gat gag gac atc ctc ttt gtc tac ttg gac agc tga cagcaggagc       721
 Thr Asp Glu Asp Ile Leu Phe Val Tyr Leu Asp Ser 
 225                 230                 235

 ctggtgcgcc taggtctgac ggccgcgaat ttagtagtag ta                       763




      <210> 235
      <211> 1195
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (270)..(866)

      <400> 235
 ccgggtcgac ccacgcgtcc ggctgtgatt ctcactatac tggtcctgag gaaagggctt     60

 ctgtgaactg cggtttttag tttttattgt ggttcttagt tctcatgaga cccctcttga    120

 ggatatgtgc ctatctggtg cctctgctct ccactagttg agtgaaagga aggaggtaat    180

 ttaccaccat gtttggttcc tgtttataag atgttttaag aaagatttga aacagatttt    240

 ctgaagaaag cagaagctct cttcccatt  atg act tcg gaa atc act tat gct     293
                                  Met Thr Ser Glu Ile Thr Tyr Ala
                                    1               5

 gaa gtg agg ttc aaa aat gaa ttc aag tcc tca ggc atc aac aca gcc      341
 Glu Val Arg Phe Lys Asn Glu Phe Lys Ser Ser Gly Ile Asn Thr Ala
      10                  15                  20

 tct tct gca gtt ttc ttt caa aaa tat tct cag ctt ctt gaa aaa aag      389
 Ser Ser Ala Val Phe Phe Gln Lys Tyr Ser Gln Leu Leu Glu Lys Lys
  25                  30                  35                  40

 act aca aaa gag ctg gtt cat aca aca ttg gag tgt gtg aaa aaa aat      437
 Thr Thr Lys Glu Leu Val His Thr Thr Leu Glu Cys Val Lys Lys Asn
                  45                  50                  55

 atg ccc gtg gaa gag aca gcc tgg agc tgt tgc cca aag aat tgg aag      485
 Met Pro Val Glu Glu Thr Ala Trp Ser Cys Cys Pro Lys Asn Trp Lys
              60                  65                  70

 tca ttt agt tcc aac tgc tac ttt att tct act gaa tca gca tct tgg      533
 Ser Phe Ser Ser Asn Cys Tyr Phe Ile Ser Thr Glu Ser Ala Ser Trp
          75                  80                  85

 caa gac agt gag aag gac tgt gct aga atg gag gct cac ctg ctg gtg      581
 Gln Asp Ser Glu Lys Asp Cys Ala Arg Met Glu Ala His Leu Leu Val
      90                  95                 100

 ata aac act caa gaa gag cag gat ttc atc ttc cag aat ctg caa gaa      629
 Ile Asn Thr Gln Glu Glu Gln Asp Phe Ile Phe Gln Asn Leu Gln Glu
 105                 110                 115                 120

 gaa tct gct tat ttt gtg ggg ctc tca gat cca gaa ggt cag cga cat      677
 Glu Ser Ala Tyr Phe Val Gly Leu Ser Asp Pro Glu Gly Gln Arg His
                 125                 130                 135

 tgg caa tgg gtt gat cag aca cca tac aat gaa agt tcc aca ttc tgg      725
 Trp Gln Trp Val Asp Gln Thr Pro Tyr Asn Glu Ser Ser Thr Phe Trp
             140                 145                 150

 cat cca cgt gag ccc agt gat ccc aat gag cgc tgc gtt gtg cta aat      773
 His Pro Arg Glu Pro Ser Asp Pro Asn Glu Arg Cys Val Val Leu Asn
         155                 160                 165

 ttt cgt aaa tca ccc aaa aga tgg ggc tgg aat gat gtt aat tgt ctt      821
 Phe Arg Lys Ser Pro Lys Arg Trp Gly Trp Asn Asp Val Asn Cys Leu
     170                 175                 180

 ggt cct caa agg tca gtt tgt gag atg atg aag atc cac tta tga act      869
 Gly Pro Gln Arg Ser Val Cys Glu Met Met Lys Ile His Leu 
 185                 190                 195

 gaacattctc catgaacagg tggttggatt ggtatctgtc attgtaggga tagataataa    929

 gctcttctta ttcatgtgta agggaggtcc atagaattta ggtggtctgt caactattct    989

 acttatgaga gaattggtct gtacattgac tgattcactt tttcataaag tgagcattta   1049

 ttgagcattt tttcatgtgc cagagcctgt actggaggcc cccattgtgc acacatggag   1109

 agaacatgag tctctcttaa tttttatctg gttgctaaag aattatttac caataaaatt   1169

 atatgatgtg gtgtcaaaaa aaaaaa                                        1195




      <210> 236
      <211> 1097
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (406)..(966)

      <400> 236
 tgccaaagcg tagtacccaa ccctcaaatt gtttcgtaat gggatgatga tgaagagaga     60

 atacaggggt cagcgatcag tgaaagcatt ggcagattac atcaggcaac aaaaaagtga    120

 ccccattcaa gaaattcggg acttagcaga aatcaccact cttgatcgca gcaaaagaaa    180

 tatcattgga tattttgagc aaaaggactc ggacaactat agagtttttg aacgagtagc    240

 gaatattttg catgatgact gtgcctttct ttctgcattt ggggatgttt caaaaccgga    300

 aagatatagt ggcgacaaca taatctacaa accaccaggg cattctgctc cggatatagt    360

 ggcgacaaca taatctacaa accaccaggg cattctgctc cggat    atg gtg tac     414
                                                      Met Val Tyr
                                                        1

 ttg gga gct atg aca aat ttt gat gtg act tac aat tgg att caa gat      462
 Leu Gly Ala Met Thr Asn Phe Asp Val Thr Tyr Asn Trp Ile Gln Asp
       5                  10                  15

 aaa tgt gtt cct ctt gtc cga gaa ata aca ttt gaa aat gga gag gaa      510
 Lys Cys Val Pro Leu Val Arg Glu Ile Thr Phe Glu Asn Gly Glu Glu
  20                  25                  30                  35

 ttg aca gaa gaa gga ctg cct ttt ctc ata ctc ttt cac atg aaa gaa      558
 Leu Thr Glu Glu Gly Leu Pro Phe Leu Ile Leu Phe His Met Lys Glu
                  40                  45                  50

 gat aca gaa agt tta gaa ata ttc cag aat gaa gta gct cgg caa tta      606
 Asp Thr Glu Ser Leu Glu Ile Phe Gln Asn Glu Val Ala Arg Gln Leu
              55                  60                  65

 ata agt gaa aaa ggt aca ata aac ttt tta cat gcc gat tgt gac aaa      654
 Ile Ser Glu Lys Gly Thr Ile Asn Phe Leu His Ala Asp Cys Asp Lys
          70                  75                  80

 ttt aga cat cct ctt ctg cac ata cag aaa act cca gca gat tgt cct      702
 Phe Arg His Pro Leu Leu His Ile Gln Lys Thr Pro Ala Asp Cys Pro
      85                  90                  95

 gta atc gct att gac agc ttt agg cat atg tat gtg ttt gga gac ttc      750
 Val Ile Ala Ile Asp Ser Phe Arg His Met Tyr Val Phe Gly Asp Phe
 100                 105                 110                 115

 aaa gat gta tta att cct gga aaa ctc aag caa ttc gta ttt gac tta      798
 Lys Asp Val Leu Ile Pro Gly Lys Leu Lys Gln Phe Val Phe Asp Leu
                 120                 125                 130

 cat tct gga aaa ctg cac aga gaa ttc cat cat gga cct gac cca act      846
 His Ser Gly Lys Leu His Arg Glu Phe His His Gly Pro Asp Pro Thr
             135                 140                 145

 gat aca gcc cca gga gag caa gcc caa gat gta gca agc agt cca cct      894
 Asp Thr Ala Pro Gly Glu Gln Ala Gln Asp Val Ala Ser Ser Pro Pro
         150                 155                 160

 gag agc tcc ttc cag aaa cta gca ccc agt gaa tat agg tat act cta      942
 Glu Ser Ser Phe Gln Lys Leu Ala Pro Ser Glu Tyr Arg Tyr Thr Leu
     165                 170                 175

 ttg agg gat cga gat gag ctt taa aaacttgaaa aacagtttgt aagcctttca     996
 Leu Arg Asp Arg Asp Glu Leu 
 180                 185

 acagcagcat caacctacgt ggtggaaata gtaaacctat attttcataa ttctatgtgt   1056

 atttttattt tgaataaaca gaaagaaatt taaaaaaaaa a                       1097




      <210> 237
      <211> 4435
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (248)..(3943)

      <400> 237
 gcacgaggca ctcacctgtg tgtgatctga cccatgtgtg gcggagcctg tgtgtgtgtg     60

 tgaggcagtg cttagtgtgc tcctggggat gagcgcatgc gtgtgaggtg gctgaggctg    120

 ggtcccctgt ccgcgtgcgt gccggtgtgc accgtgtctg tgtgtgcaca cccagtactg    180

 acaggcttcc tttctgattc ccccagggtc ttacaggaga ggggaccgtc ctgggctggc    240

 ctggacc  atg gtg ctg ctc tgg gag cct gca gga gcc tgg ctt gct ctg     289
          Met Val Leu Leu Trp Glu Pro Ala Gly Ala Trp Leu Ala Leu
            1               5                  10

 ggc ctg gcc ctg gcc ctg ggc ccc agc gtg gcc gca gct gcc cct cgg      337
 Gly Leu Ala Leu Ala Leu Gly Pro Ser Val Ala Ala Ala Ala Pro Arg
  15                  20                  25                  30

 cag gac tgc acg ggc gtg gag tgc ccg ccg ctg gag acc tgc att gag      385
 Gln Asp Cys Thr Gly Val Glu Cys Pro Pro Leu Glu Thr Cys Ile Glu
                  35                  40                  45

 gag gcg ctg gag ccg ggt gcc tgc tgt gcc acg tgt gtg cag cag ggc      433
 Glu Ala Leu Glu Pro Gly Ala Cys Cys Ala Thr Cys Val Gln Gln Gly
              50                  55                  60

 tgc gcc tgc gag ggc tac cag tac tat gac tgc cta cag ggt ggc ttc      481
 Cys Ala Cys Glu Gly Tyr Gln Tyr Tyr Asp Cys Leu Gln Gly Gly Phe
          65                  70                  75

 gtg cgc ggc cgc gtg ccc gcc ggt cag tcc tat ttt gtg gac ttc ggg      529
 Val Arg Gly Arg Val Pro Ala Gly Gln Ser Tyr Phe Val Asp Phe Gly
      80                  85                  90

 agc act gag tgc tcc tgc cca cca ggc ggc ggc aag atc agc tgc cag      577
 Ser Thr Glu Cys Ser Cys Pro Pro Gly Gly Gly Lys Ile Ser Cys Gln
  95                 100                 105                 110

 ttc atg ctg tgc ccg gag ctg ccg ccc aac tgc atc gag gct gta gtg      625
 Phe Met Leu Cys Pro Glu Leu Pro Pro Asn Cys Ile Glu Ala Val Val
                 115                 120                 125

 gtg gct gac agc tgc cca cag tgc ggc cag gtg ggc tgc gtc cac gcg      673
 Val Ala Asp Ser Cys Pro Gln Cys Gly Gln Val Gly Cys Val His Ala
             130                 135                 140

 ggc cac gag tac gcc gct ggc cac act gtt cac ctg ccg ccc tgc cgg      721
 Gly His Glu Tyr Ala Ala Gly His Thr Val His Leu Pro Pro Cys Arg
         145                 150                 155

 gcc tgc cac tgc cct gac gcc ggt gga gag ctc atc tgc tac cag ctc      769
 Ala Cys His Cys Pro Asp Ala Gly Gly Glu Leu Ile Cys Tyr Gln Leu
     160                 165                 170

 ccc ggt tgc cac ggg aac ttc tca gat gcc gag gag ggt gac ccc gag      817
 Pro Gly Cys His Gly Asn Phe Ser Asp Ala Glu Glu Gly Asp Pro Glu
 175                 180                 185                 190

 cga cac tac gaa gac ccc tac agc tat gac cag gag gtg gcc gag gtg      865
 Arg His Tyr Glu Asp Pro Tyr Ser Tyr Asp Gln Glu Val Ala Glu Val
                 195                 200                 205

 gaa gca gca aca gcc ctg ggg ggt gag gtc cag gcg ggt gca gtc cag      913
 Glu Ala Ala Thr Ala Leu Gly Gly Glu Val Gln Ala Gly Ala Val Gln
             210                 215                 220

 gca ggc gca ggg ggc ccc cca gct gct ctg gga ggt ggg agt cag cca      961
 Ala Gly Ala Gly Gly Pro Pro Ala Ala Leu Gly Gly Gly Ser Gln Pro
         225                 230                 235

 ctg tcc acc atc cag gca ccc ccc tgg cca gct gtc ctc ccc agg ccc     1009
 Leu Ser Thr Ile Gln Ala Pro Pro Trp Pro Ala Val Leu Pro Arg Pro
     240                 245                 250

 aca gcg gct gct gcc ctg ggt ccc cca gcc cca gtg cag gcc aaa gct     1057
 Thr Ala Ala Ala Ala Leu Gly Pro Pro Ala Pro Val Gln Ala Lys Ala
 255                 260                 265                 270

 agg aga gtg acc gag gac agt gag gag gaa gaa gag gag gag gag gag     1105
 Arg Arg Val Thr Glu Asp Ser Glu Glu Glu Glu Glu Glu Glu Glu Glu
                 275                 280                 285

 aga gag gaa atg gct gtc act gag cag ctg gca gca ggt ggc cac agg     1153
 Arg Glu Glu Met Ala Val Thr Glu Gln Leu Ala Ala Gly Gly His Arg
             290                 295                 300

 ggg ctg gat ggg ctg ccc act aca gcc cca gct gga ccc agt ctt cct     1201
 Gly Leu Asp Gly Leu Pro Thr Thr Ala Pro Ala Gly Pro Ser Leu Pro
         305                 310                 315

 atc cag gag gag agg gca gaa gct ggg gca agg gca gaa gct ggg gca     1249
 Ile Gln Glu Glu Arg Ala Glu Ala Gly Ala Arg Ala Glu Ala Gly Ala
     320                 325                 330

 agg cct gaa gag aac ctc atc ctg gat gcc caa gcc acg tcc cgc agc     1297
 Arg Pro Glu Glu Asn Leu Ile Leu Asp Ala Gln Ala Thr Ser Arg Ser
 335                 340                 345                 350

 act ggg ccg gag ggc gtg acg cat gca ccg agc ctg ggc aag gct gct     1345
 Thr Gly Pro Glu Gly Val Thr His Ala Pro Ser Leu Gly Lys Ala Ala
                 355                 360                 365

 ctc gtc cca act cag gcc gtg cct ggc tct ccc agg gac cca gtc aag     1393
 Leu Val Pro Thr Gln Ala Val Pro Gly Ser Pro Arg Asp Pro Val Lys
             370                 375                 380

 ccc agc ccc cac aac atc ctg tcc aca tca ctg cct gat gca gcc tgg     1441
 Pro Ser Pro His Asn Ile Leu Ser Thr Ser Leu Pro Asp Ala Ala Trp
         385                 390                 395

 atc cca ccc acc cga gaa gtg ccc agg aag ccg caa gtt ctg ccc cat     1489
 Ile Pro Pro Thr Arg Glu Val Pro Arg Lys Pro Gln Val Leu Pro His
     400                 405                 410

 tcc cac gtg gag gag gac aca gac ccc aac tct gtc cat tct atc ccc     1537
 Ser His Val Glu Glu Asp Thr Asp Pro Asn Ser Val His Ser Ile Pro
 415                 420                 425                 430

 aga agt agc cct gaa ggc tcc acc aag gac ctg atc gag act tgc tgc     1585
 Arg Ser Ser Pro Glu Gly Ser Thr Lys Asp Leu Ile Glu Thr Cys Cys
                 435                 440                 445

 gca gcc gga cag cag tgg gcc att gac aat gac gag tgc ctg gag atc     1633
 Ala Ala Gly Gln Gln Trp Ala Ile Asp Asn Asp Glu Cys Leu Glu Ile
             450                 455                 460

 cct gag agt ggc act gag gac aac gtc tgc agg aca gcc cag agg cac     1681
 Pro Glu Ser Gly Thr Glu Asp Asn Val Cys Arg Thr Ala Gln Arg His
         465                 470                 475

 tgc tgt gtc tcc tac ttg cag gag aag agc tgc atg gcc ggc gtc ctg     1729
 Cys Cys Val Ser Tyr Leu Gln Glu Lys Ser Cys Met Ala Gly Val Leu
     480                 485                 490

 gga gcc aag gag ggt gag acc tgt ggg gct gag gac aac gac agc tgc     1777
 Gly Ala Lys Glu Gly Glu Thr Cys Gly Ala Glu Asp Asn Asp Ser Cys
 495                 500                 505                 510

 ggc atc tcc ctg tac aag caa tgc tgt gac tgc tgt ggc ctg ggc ctc     1825
 Gly Ile Ser Leu Tyr Lys Gln Cys Cys Asp Cys Cys Gly Leu Gly Leu
                 515                 520                 525

 cgc gtg cgg gcc gag ggc cag tcg tgt gag tcc aat cct aac ctg ggc     1873
 Arg Val Arg Ala Glu Gly Gln Ser Cys Glu Ser Asn Pro Asn Leu Gly
             530                 535                 540

 tat ccc tgc aat cat gtc atg ctc tcc tgc tgt gag ggt gaa gag cct     1921
 Tyr Pro Cys Asn His Val Met Leu Ser Cys Cys Glu Gly Glu Glu Pro
         545                 550                 555

 ctc ata gta cct gag gtt cgc cga cct cca gag ccc gca gct gca cca     1969
 Leu Ile Val Pro Glu Val Arg Arg Pro Pro Glu Pro Ala Ala Ala Pro
     560                 565                 570

 cgg aga gtt tca gag gca gag atg gcg ggc cga gag gcc ctg tca ctg     2017
 Arg Arg Val Ser Glu Ala Glu Met Ala Gly Arg Glu Ala Leu Ser Leu
 575                 580                 585                 590

 ggc aca gag gcc gag ctg ccg aac agc ctg ccg ggc gat gac cag gat     2065
 Gly Thr Glu Ala Glu Leu Pro Asn Ser Leu Pro Gly Asp Asp Gln Asp
                 595                 600                 605

 gag tgc ctt ctc ctc ccg gga gag ctg tgc cag cac ctt tgc atc aat     2113
 Glu Cys Leu Leu Leu Pro Gly Glu Leu Cys Gln His Leu Cys Ile Asn
             610                 615                 620

 act gtg ggt tct tac cac tgt gcc tgc ttt cct ggc ttc tca ctg cag     2161
 Thr Val Gly Ser Tyr His Cys Ala Cys Phe Pro Gly Phe Ser Leu Gln
         625                 630                 635

 gac gat ggc cgc act tgc cgc cca gag ggt cac cct cca cag ccg gaa     2209
 Asp Asp Gly Arg Thr Cys Arg Pro Glu Gly His Pro Pro Gln Pro Glu
     640                 645                 650

 gcc cca cag gag cct gca ctg aag tca gaa ttt tcc cag gtg gcc tct     2257
 Ala Pro Gln Glu Pro Ala Leu Lys Ser Glu Phe Ser Gln Val Ala Ser
 655                 660                 665                 670

 aac acc atc ccg ctg cca ctg ccg cag ccc aat acc tgc aaa gac aat     2305
 Asn Thr Ile Pro Leu Pro Leu Pro Gln Pro Asn Thr Cys Lys Asp Asn
                 675                 680                 685

 gga ccc tgc aag cag gtg tgc agc act gtt ggg ggc tca gcc ata tgc     2353
 Gly Pro Cys Lys Gln Val Cys Ser Thr Val Gly Gly Ser Ala Ile Cys
             690                 695                 700

 tcc tgt ttt ccc ggc tat gcc atc atg gcg gat ggc gtg tcc tgt gaa     2401
 Ser Cys Phe Pro Gly Tyr Ala Ile Met Ala Asp Gly Val Ser Cys Glu
         705                 710                 715

 gac caa gac gag tgc ctg atg ggt gct cac gat tgt agc cgg cga cag     2449
 Asp Gln Asp Glu Cys Leu Met Gly Ala His Asp Cys Ser Arg Arg Gln
     720                 725                 730

 ttc tgt gtg aac acc ctg gga tcc ttc tac tgt gtc aac cac aca gtg     2497
 Phe Cys Val Asn Thr Leu Gly Ser Phe Tyr Cys Val Asn His Thr Val
 735                 740                 745                 750

 ctc tgt gcc gat ggc tat atc ctc aat gcg cac agg aag tgc gtg gac     2545
 Leu Cys Ala Asp Gly Tyr Ile Leu Asn Ala His Arg Lys Cys Val Asp
                 755                 760                 765

 atc aac gag tgt gtg acg gac ctg cac acg tgc agc cgg ggc gag cac     2593
 Ile Asn Glu Cys Val Thr Asp Leu His Thr Cys Ser Arg Gly Glu His
             770                 775                 780

 tgt gtg aac aca ctg ggc tcc ttc cac tgc tac aag gca ctc acc tgt     2641
 Cys Val Asn Thr Leu Gly Ser Phe His Cys Tyr Lys Ala Leu Thr Cys
         785                 790                 795

 gag cca ggc tat gcc ctc aag gat ggc gag tgc gaa gac gtg gat gag     2689
 Glu Pro Gly Tyr Ala Leu Lys Asp Gly Glu Cys Glu Asp Val Asp Glu
     800                 805                 810

 tgt gcg atg ggc acg cac acc tgc cag ccg ggc ttc ttg tgc cag aac     2737
 Cys Ala Met Gly Thr His Thr Cys Gln Pro Gly Phe Leu Cys Gln Asn
 815                 820                 825                 830

 acc aag ggc tcc ttc tac tgc cag gcc agg cag cgc tgc atg gat ggc     2785
 Thr Lys Gly Ser Phe Tyr Cys Gln Ala Arg Gln Arg Cys Met Asp Gly
                 835                 840                 845

 ttc ctg cag gat cct gaa ggc aac tgt gtg gac atc aac gag tgc acg     2833
 Phe Leu Gln Asp Pro Glu Gly Asn Cys Val Asp Ile Asn Glu Cys Thr
             850                 855                 860

 tca ctg tcc gag cca tgt cgg cca ggc ttc agc tgc atc aac acg gtg     2881
 Ser Leu Ser Glu Pro Cys Arg Pro Gly Phe Ser Cys Ile Asn Thr Val
         865                 870                 875

 ggc tcc tac acg tgc cag agg aac ccg ctg atc tgc gcg cgc ggc tac     2929
 Gly Ser Tyr Thr Cys Gln Arg Asn Pro Leu Ile Cys Ala Arg Gly Tyr
     880                 885                 890

 cac gcc agc gat gat ggg gcc aag tgt gtg gac gtg aat gag tgt gag     2977
 His Ala Ser Asp Asp Gly Ala Lys Cys Val Asp Val Asn Glu Cys Glu
 895                 900                 905                 910

 aca ggt gtg cac cgc tgc ggt gag ggc caa gtg tgc cac aac ctc cct     3025
 Thr Gly Val His Arg Cys Gly Glu Gly Gln Val Cys His Asn Leu Pro
                 915                 920                 925

 ggc tcc tac cgc tgt gac tgc aaa gcc ggc ttt cag cgg gat gcc ttc     3073
 Gly Ser Tyr Arg Cys Asp Cys Lys Ala Gly Phe Gln Arg Asp Ala Phe
             930                 935                 940

 ggc cgg ggc tgc atc gac gtg aat gag tgc tgg gcc tcg cca ggc cgc     3121
 Gly Arg Gly Cys Ile Asp Val Asn Glu Cys Trp Ala Ser Pro Gly Arg
         945                 950                 955

 ctg tgc cag cac acg tgt gag aac aca ctc ggc tcc tac cgc tgt tcc     3169
 Leu Cys Gln His Thr Cys Glu Asn Thr Leu Gly Ser Tyr Arg Cys Ser
     960                 965                 970

 tgc gcc tcc ggg ttc ctg cta gca gcg gac ggc aag cgc tgt gaa gac     3217
 Cys Ala Ser Gly Phe Leu Leu Ala Ala Asp Gly Lys Arg Cys Glu Asp
 975                 980                 985                 990

 gtg aat gag tgt gag gcc cag cgc tgc agc cag gag tgt gcc aac atc     3265
 Val Asn Glu Cys Glu Ala Gln Arg Cys Ser Gln Glu Cys Ala Asn Ile
                 995                1000                1005

 tat ggc tcc tac cag tgc tac tgc cgc cag ggc tac cag ctg gct gag     3313
 Tyr Gly Ser Tyr Gln Cys Tyr Cys Arg Gln Gly Tyr Gln Leu Ala Glu
            1010                1015                1020

 gat ggg cac acc tgc aca gac atc gac gag tgt gct caa ggc gcc ggc     3361
 Asp Gly His Thr Cys Thr Asp Ile Asp Glu Cys Ala Gln Gly Ala Gly
        1025                1030                1035

 atc ctc tgc acc ttc cgc tgt ctc aac gtg cca ggg agc tac cag tgt     3409
 Ile Leu Cys Thr Phe Arg Cys Leu Asn Val Pro Gly Ser Tyr Gln Cys
    1040                1045                1050

 gca tgc cct gag cag ggc tac acc atg acg gcc aac ggg agg tcc tgc     3457
 Ala Cys Pro Glu Gln Gly Tyr Thr Met Thr Ala Asn Gly Arg Ser Cys
1055                1060                1065                1070

 aag gac gtg gat gag tgt gca ctg ggc acc cac aac tgt tcc gag gct     3505
 Lys Asp Val Asp Glu Cys Ala Leu Gly Thr His Asn Cys Ser Glu Ala
                1075                1080                1085

 gag acc tgc cac aac atc cag ggt agc ttc cgc tgc ctg cgc ttc gag     3553
 Glu Thr Cys His Asn Ile Gln Gly Ser Phe Arg Cys Leu Arg Phe Glu
            1090                1095                1100

 tgt cct ccc aac tat gtc caa gtc tcc aaa acg aag tgc gag cgc acc     3601
 Cys Pro Pro Asn Tyr Val Gln Val Ser Lys Thr Lys Cys Glu Arg Thr
        1105                1110                1115

 acg tgc cat gac ttc ctg gag tgc cag aac tcg cca gcg cgc atc acg     3649
 Thr Cys His Asp Phe Leu Glu Cys Gln Asn Ser Pro Ala Arg Ile Thr
    1120                1125                1130

 cac tac cag ctc aac ttc cag acg ggc ctc ctg gtg cct gcg cat atc     3697
 His Tyr Gln Leu Asn Phe Gln Thr Gly Leu Leu Val Pro Ala His Ile
1135                1140                1145                1150

 ttc cgc att ggc ccc gcg cca gcc ttc acg ggg gac acc atc gcc ctg     3745
 Phe Arg Ile Gly Pro Ala Pro Ala Phe Thr Gly Asp Thr Ile Ala Leu
                1155                1160                1165

 aac atc atc aag ggc aat gag gag ggc tac ttt ggc acg cgc agg ctc     3793
 Asn Ile Ile Lys Gly Asn Glu Glu Gly Tyr Phe Gly Thr Arg Arg Leu
            1170                1175                1180

 aat gcc tac acg ggt gtg gtc tac ctg cag cgg gcc gtg ctg gag ccc     3841
 Asn Ala Tyr Thr Gly Val Val Tyr Leu Gln Arg Ala Val Leu Glu Pro
        1185                1190                1195

 cgg gac ttt gcc ctg gac gtg gag atg aag ctc tgg agg cag ggc tcc     3889
 Arg Asp Phe Ala Leu Asp Val Glu Met Lys Leu Trp Arg Gln Gly Ser
    1200                1205                1210

 gtc acc acc ttc ctg gcc aag atg cac atc ttc ttc acc acc ttt gcc     3937
 Val Thr Thr Phe Leu Ala Lys Met His Ile Phe Phe Thr Thr Phe Ala
1215                1220                1225                1230

 ctg tga ggtgccagca cgggccacct gcgggtgtgg cacctcacag ggctcacact      3993
 Leu 


 gcgtgggagg gactgggtca ctattgtggt ttttactata actttgtaaa ttaacttaat   4053

 tttgctgact tgactcctgt ggcttctgga cccctcctct gccccgcagg aggaagttcc   4113

 acggcaggtg gtgcgttccc acgcaggcac caagtggaag cttgcacggt gggccacggc   4173

 cgtggcgggt gccctgtggg tgaggctggg tgatgacctg aggaccagag acacgcgacc   4233

 atgttggggc tcttggactc ctctggatga cccgtcccca aagttgacat tccatttcat   4293

 gttccactgt gattaattct tttctttttt aaaaaatcat tttaaagttt tttgtttaac   4353

 tataaagtag tacatgtaca ttatataaaa aaaagttcaa ctagtatgaa agggttataa   4413

 agtaacagag gaaaaaaaaa aa                                            4435




      <210> 238
      <211> 882
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (109)..(882)

      <400> 238
 taagcttgcg gccgcctcag agaatgaaga tctagaaaac aaggatacct ctttattggc     60

 ttctgccacc gatccagaac cctgctcctc accccacaga ggccacag atg gta tct     117
                                                      Met Val Ser
                                                        1

 cca gtg agt aag gat gcc acg gaa gat ctg cgg aaa gca act ggt cct      165
 Pro Val Ser Lys Asp Ala Thr Glu Asp Leu Arg Lys Ala Thr Gly Pro
       5                  10                  15

 ttg gag gct cag gcc ttg gtg aaa cag gat ttg ctg cct gca gac cag      213
 Leu Glu Ala Gln Ala Leu Val Lys Gln Asp Leu Leu Pro Ala Asp Gln
  20                  25                  30                  35

 gcc cag gtc ctc aat gag atg gct aag tat caa gtt cca cag agg tct      261
 Ala Gln Val Leu Asn Glu Met Ala Lys Tyr Gln Val Pro Gln Arg Ser
                  40                  45                  50

 ggg gac atc gtt atg atc cag tct gaa cat aca gga gct ata gat gtt      309
 Gly Asp Ile Val Met Ile Gln Ser Glu His Thr Gly Ala Ile Asp Val
              55                  60                  65

 ctt tca gct gat ttg gaa tct gca gat ctt ctg ggg gac cac agg aaa      357
 Leu Ser Ala Asp Leu Glu Ser Ala Asp Leu Leu Gly Asp His Arg Lys
          70                  75                  80

 gtc tcc cca cct ctg atg gct cct cca tgc atc tgg acc ttt gcc aag      405
 Val Ser Pro Pro Leu Met Ala Pro Pro Cys Ile Trp Thr Phe Ala Lys
      85                  90                  95

 gtg aag gaa ttc aaa agc aag ctg ggc aaa gag aag aac agc cgt ctg      453
 Val Lys Glu Phe Lys Ser Lys Leu Gly Lys Glu Lys Asn Ser Arg Leu
 100                 105                 110                 115

 gtg gtg aag cgt ggt gag gtg gtg acc atc cgg gta cct act cat cca      501
 Val Val Lys Arg Gly Glu Val Val Thr Ile Arg Val Pro Thr His Pro
                 120                 125                 130

 gag ggg aag cgt gtc tgc tgg gag ttt gcg acc gat gac tat gac att      549
 Glu Gly Lys Arg Val Cys Trp Glu Phe Ala Thr Asp Asp Tyr Asp Ile
             135                 140                 145

 ggc ttt gga gtt tat ttt gac tgg acc cct gta act agc act gac ata      597
 Gly Phe Gly Val Tyr Phe Asp Trp Thr Pro Val Thr Ser Thr Asp Ile
         150                 155                 160

 act gtg cag gtc agt gat tcc agt gac gat gag gat gaa gaa gag gaa      645
 Thr Val Gln Val Ser Asp Ser Ser Asp Asp Glu Asp Glu Glu Glu Glu
     165                 170                 175

 gag gag gaa gag att gaa gaa ccc gtt cca gct gga gat gtg gag aga      693
 Glu Glu Glu Glu Ile Glu Glu Pro Val Pro Ala Gly Asp Val Glu Arg
 180                 185                 190                 195

 ggc tcc agg agc tcc ttg cgg ggt cgc tat ggg gag gtc atg cct gtg      741
 Gly Ser Arg Ser Ser Leu Arg Gly Arg Tyr Gly Glu Val Met Pro Val
                 200                 205                 210

 tac cgg cgg gac agc cac cga gac gtg cag gct ggc agc cat gac tac      789
 Tyr Arg Arg Asp Ser His Arg Asp Val Gln Ala Gly Ser His Asp Tyr
             215                 220                 225

 cct ggt gag ggc atc tac ctg ctc aag ttc gac aac tcc tac tcc ctg      837
 Pro Gly Glu Gly Ile Tyr Leu Leu Lys Phe Asp Asn Ser Tyr Ser Leu
         230                 235                 240

 ctg cgc aac aag act ctc tac ttc cac atc tac tac acc agc tga          882
 Leu Arg Asn Lys Thr Leu Tyr Phe His Ile Tyr Tyr Thr Ser 
     245                 250                 255





      <210> 239
      <211> 946
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (73)..(810)

      <400> 239
 cacaaaaaga cccagagctg ttttcttagg gtgcatcctt tgtttttctg gttttggtct     60

 tttcatcaca gg    atg gca tta gct ctg tgt ctg cag gtg ctg tgc agc     108
                  Met Ala Leu Ala Leu Cys Leu Gln Val Leu Cys Ser
                    1               5                  10

 ctg tgt ggc tgg ctc tcg ctc tat att tct ttc tgc cac ctg aat aag      156
 Leu Cys Gly Trp Leu Ser Leu Tyr Ile Ser Phe Cys His Leu Asn Lys
          15                  20                  25

 cac cga agc tat gag tgg agc tgc cgc ctg gtc acc ttc acc cat gga      204
 His Arg Ser Tyr Glu Trp Ser Cys Arg Leu Val Thr Phe Thr His Gly
      30                  35                  40

 gtc ctc tct ata ggc ctc tcc gct tat att ggc ttc att gat ggc cca      252
 Val Leu Ser Ile Gly Leu Ser Ala Tyr Ile Gly Phe Ile Asp Gly Pro
  45                  50                  55                  60

 tgg cct ttt acc cac cca ggc tca ccc aat aca cct ctc caa gtt cat      300
 Trp Pro Phe Thr His Pro Gly Ser Pro Asn Thr Pro Leu Gln Val His
                  65                  70                  75

 gtc ctg tgt ctc acc ttg ggc tac ttc atc ttc gac ttg ggc tgg tgc      348
 Val Leu Cys Leu Thr Leu Gly Tyr Phe Ile Phe Asp Leu Gly Trp Cys
              80                  85                  90

 gtc tac ttt cag tct gag ggt gcc ttg atg ctg gct cat cac aca ttg      396
 Val Tyr Phe Gln Ser Glu Gly Ala Leu Met Leu Ala His His Thr Leu
          95                 100                 105

 agt atc ttg ggc att atc atg gcc ctt gtg ctt ggg gag tct ggc aca      444
 Ser Ile Leu Gly Ile Ile Met Ala Leu Val Leu Gly Glu Ser Gly Thr
     110                 115                 120

 gag gtc aat gca gtc ctc ttt gga agt gag ctt acc aac ccc ttg cta      492
 Glu Val Asn Ala Val Leu Phe Gly Ser Glu Leu Thr Asn Pro Leu Leu
 125                 130                 135                 140

 cag atg cgc tgg ttt ctc cgg gaa aca ggg cac tat cac agt ttc act      540
 Gln Met Arg Trp Phe Leu Arg Glu Thr Gly His Tyr His Ser Phe Thr
                 145                 150                 155

 gga gat gta gtg gac ttc ctc ttt gtg gct ctg ttc aca gga gtg agg      588
 Gly Asp Val Val Asp Phe Leu Phe Val Ala Leu Phe Thr Gly Val Arg
             160                 165                 170

 att ggt gtg gga gct tgc ctc ctt ttc tgt gaa atg gtc tcc ccc acg      636
 Ile Gly Val Gly Ala Cys Leu Leu Phe Cys Glu Met Val Ser Pro Thr
         175                 180                 185

 cct aag tgg ttt gtg aag gct ggg gga gta gcg atg tat gct gtg tct      684
 Pro Lys Trp Phe Val Lys Ala Gly Gly Val Ala Met Tyr Ala Val Ser
     190                 195                 200

 tgg tgt ttc atg ttt agc atc tgg cgc ttt gca tgg agg aag agc atc      732
 Trp Cys Phe Met Phe Ser Ile Trp Arg Phe Ala Trp Arg Lys Ser Ile
 205                 210                 215                 220

 aag aag tac cat gct tgg aga agc agg cgg agt gag gaa cgg cag ctg      780
 Lys Lys Tyr His Ala Trp Arg Ser Arg Arg Ser Glu Glu Arg Gln Leu
                 225                 230                 235

 aaa cac aac gga cat ctc aaa ata cac tag c caaggcttgc tccagattat      831
 Lys His Asn Gly His Leu Lys Ile His 
             240                 245

 ggattgggtt aagtcagcca tgggaaccag gttggaaata tgactgttac ataattacac    891

 ttataacaaa cttaggtttc aataaagggc taaatgtatt gatcaaaaaa aaaaa         946




      <210> 240
      <211> 346
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (63)..(323)

      <400> 240
 ccgctctgga ccgtctcaag gtgtttgacg gcatcccacc gccctacgac aagaaaaagc     60

 gg   atg gtg gtt cct gct gcc ctc aag gtc gtg cgt ctg aag cct aca     107
      Met Val Val Pro Ala Ala Leu Lys Val Val Arg Leu Lys Pro Thr
        1               5                  10                  15

 aga aag ttt gcc tat ctg ggg cgc ctg gct cac gag gtt ggc tgg aag      155
 Arg Lys Phe Ala Tyr Leu Gly Arg Leu Ala His Glu Val Gly Trp Lys
                  20                  25                  30

 tac cag gca gtg aca gcc acc ctg gag gag aag agg aaa gag aaa gcc      203
 Tyr Gln Ala Val Thr Ala Thr Leu Glu Glu Lys Arg Lys Glu Lys Ala
              35                  40                  45

 aag atc cac tac cgg aag aag aaa cag ctc atg agg cta cgg aaa cag      251
 Lys Ile His Tyr Arg Lys Lys Lys Gln Leu Met Arg Leu Arg Lys Gln
          50                  55                  60

 gcc gag aag aac gtg gag aag aaa att gac aaa tac aca gag gtc ctc      299
 Ala Glu Lys Asn Val Glu Lys Lys Ile Asp Lys Tyr Thr Glu Val Leu
      65                  70                  75

 aag acc cac gga ctc ctg gtc tga gcccaataaa gactgttaat tcc            346
 Lys Thr His Gly Leu Leu Val 
  80                  85





      <210> 241
      <211> 2410
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (100)..(1776)

      <400> 241
 gtactgctcc ggaattcccg ggtcgacgat ttcgtccggc ctctagggga ggcccgagcc     60

 gtcgggcgcc ccgtccccgc gtctagttgt tcatgaagc   atg tcg gcc acc agc     114
                                              Met Ser Ala Thr Ser
                                                1               5

 gtg gac acc cag aga aca aaa gga caa gat aat aaa gta caa aat ggt      162
 Val Asp Thr Gln Arg Thr Lys Gly Gln Asp Asn Lys Val Gln Asn Gly
                  10                  15                  20

 tcg tta cat cag aag gat aca gtt cat gac aat gac ttt gag ccc tac      210
 Ser Leu His Gln Lys Asp Thr Val His Asp Asn Asp Phe Glu Pro Tyr
              25                  30                  35

 ctt act gga cag gca aat cag agt aac agt tac ccc tca atg agc gac      258
 Leu Thr Gly Gln Ala Asn Gln Ser Asn Ser Tyr Pro Ser Met Ser Asp
          40                  45                  50

 ccc tac ctg tcc agc tat tac ccg ccg tcc att gga ttt cct tac tcc      306
 Pro Tyr Leu Ser Ser Tyr Tyr Pro Pro Ser Ile Gly Phe Pro Tyr Ser
      55                  60                  65

 ctc aat gag gct ccg tgg tct act gca ggg gac cct ccg att cca tac      354
 Leu Asn Glu Ala Pro Trp Ser Thr Ala Gly Asp Pro Pro Ile Pro Tyr
  70                  75                  80                  85

 ctc acc acc tac gga cag ctc agt aac gga gac cat cat ttt atg cac      402
 Leu Thr Thr Tyr Gly Gln Leu Ser Asn Gly Asp His His Phe Met His
                  90                  95                 100

 gat gct gtt ttt ggg cag cct ggg ggc ctg ggg aac aac atc tat cag      450
 Asp Ala Val Phe Gly Gln Pro Gly Gly Leu Gly Asn Asn Ile Tyr Gln
             105                 110                 115

 cac agg ttc aat ttt ttc cct gaa aac cct gcg ttc tca gca tgg ggg      498
 His Arg Phe Asn Phe Phe Pro Glu Asn Pro Ala Phe Ser Ala Trp Gly
         120                 125                 130

 aca agt ggg tct caa ggt cag cag acc cag agc tcc gcg tat ggg agc      546
 Thr Ser Gly Ser Gln Gly Gln Gln Thr Gln Ser Ser Ala Tyr Gly Ser
     135                 140                 145

 agc tac acc tac ccc ccg agc tcc ctg ggt ggc acg gtg gtt gat ggg      594
 Ser Tyr Thr Tyr Pro Pro Ser Ser Leu Gly Gly Thr Val Val Asp Gly
 150                 155                 160                 165

 cag cca ggc ttt cac agc gac acc ctc agc aag gcc ccc ggg atg aac      642
 Gln Pro Gly Phe His Ser Asp Thr Leu Ser Lys Ala Pro Gly Met Asn
                 170                 175                 180

 agc ctg gag cag ggc atg gtt ggc ctg aag att ggg gac gtc agc tcc      690
 Ser Leu Glu Gln Gly Met Val Gly Leu Lys Ile Gly Asp Val Ser Ser
             185                 190                 195

 tcc gcc gtc aag acg gtg ggc tct gtc gtc agc agc gtg gca ctg act      738
 Ser Ala Val Lys Thr Val Gly Ser Val Val Ser Ser Val Ala Leu Thr
         200                 205                 210

 ggt gtc ctt tct ggc aac ggt ggg aca aat gtg aac atg cca gtt tca      786
 Gly Val Leu Ser Gly Asn Gly Gly Thr Asn Val Asn Met Pro Val Ser
     215                 220                 225

 aag ccg acc tcg tgg gct gcc att gcc agc aag cct gca aaa cca cag      834
 Lys Pro Thr Ser Trp Ala Ala Ile Ala Ser Lys Pro Ala Lys Pro Gln
 230                 235                 240                 245

 cct aaa atg aaa aca aag agc ggg cct gtc atg ggg ggt ggg ctg ccc      882
 Pro Lys Met Lys Thr Lys Ser Gly Pro Val Met Gly Gly Gly Leu Pro
                 250                 255                 260

 cct cca ccc ata aag cat aac atg gac att ggc acc tgg gat aac aag      930
 Pro Pro Pro Ile Lys His Asn Met Asp Ile Gly Thr Trp Asp Asn Lys
             265                 270                 275

 ggg cct gtg ccg aag gcc agt ccc cca gca ggc acc ctc tcc aca ggc      978
 Gly Pro Val Pro Lys Ala Ser Pro Pro Ala Gly Thr Leu Ser Thr Gly
         280                 285                 290

 tgc ccc aca gcc cca gca ggt ggc tca gct ctc cca gca cag ccc cca     1026
 Cys Pro Thr Ala Pro Ala Gly Gly Ser Ala Leu Pro Ala Gln Pro Pro
     295                 300                 305

 gct ttg gct caa ccg cag tat cag agc cct cag cag cca ccc cag acc     1074
 Ala Leu Ala Gln Pro Gln Tyr Gln Ser Pro Gln Gln Pro Pro Gln Thr
 310                 315                 320                 325

 cgc tgg gtt gcc cca cgc aac aga aac gcg gcg ttt ggg cag agc gga     1122
 Arg Trp Val Ala Pro Arg Asn Arg Asn Ala Ala Phe Gly Gln Ser Gly
                 330                 335                 340

 ggg gct ggc agc gat acg aac tct cct gga aac gtc cag cct aat tct     1170
 Gly Ala Gly Ser Asp Thr Asn Ser Pro Gly Asn Val Gln Pro Asn Ser
             345                 350                 355

 gcc ccc agc gtc gaa tcc cac ccc gtc ctt gaa aaa ctg aag gct gct     1218
 Ala Pro Ser Val Glu Ser His Pro Val Leu Glu Lys Leu Lys Ala Ala
         360                 365                 370

 cac agc tac aac ccg aaa gag ttt gag tgg aat ctg aaa agc ggg cgt     1266
 His Ser Tyr Asn Pro Lys Glu Phe Glu Trp Asn Leu Lys Ser Gly Arg
     375                 380                 385

 gtg ttc atc atc aag agc tac tct gag gac gac atc cac cgc tcc att     1314
 Val Phe Ile Ile Lys Ser Tyr Ser Glu Asp Asp Ile His Arg Ser Ile
 390                 395                 400                 405

 aag tac tcc atc tgg tgt agc aca gag cac ggc aac aag cgc ctg gac     1362
 Lys Tyr Ser Ile Trp Cys Ser Thr Glu His Gly Asn Lys Arg Leu Asp
                 410                 415                 420

 agc gcc ttc cgc tgc atg agc agc aag ggg ccc gtc tac ctg ctc ttc     1410
 Ser Ala Phe Arg Cys Met Ser Ser Lys Gly Pro Val Tyr Leu Leu Phe
             425                 430                 435

 agc gtc aat ggg agt ggg cat ttt tgt ggg gtg gcc gag atg aag tcc     1458
 Ser Val Asn Gly Ser Gly His Phe Cys Gly Val Ala Glu Met Lys Ser
         440                 445                 450

 ccc gtg gac tac ggc acc agt gcc ggg gtc tgg tct cag gac aag tgg     1506
 Pro Val Asp Tyr Gly Thr Ser Ala Gly Val Trp Ser Gln Asp Lys Trp
     455                 460                 465

 aag ggg aag ttt gat gtc cag tgg att ttt gtt aag gat gta ccc aat     1554
 Lys Gly Lys Phe Asp Val Gln Trp Ile Phe Val Lys Asp Val Pro Asn
 470                 475                 480                 485

 aac cag ctc cgg cac atc agg ctg gag aat aac gac aac aaa ccg gtc     1602
 Asn Gln Leu Arg His Ile Arg Leu Glu Asn Asn Asp Asn Lys Pro Val
                 490                 495                 500

 aca aac tcc cgg gac acc cag gag gtg ccc tta gaa aaa gcc aag caa     1650
 Thr Asn Ser Arg Asp Thr Gln Glu Val Pro Leu Glu Lys Ala Lys Gln
             505                 510                 515

 gtg ctg aaa att atc agt tcc tac aag cac aca acc tcc atc ttc gac     1698
 Val Leu Lys Ile Ile Ser Ser Tyr Lys His Thr Thr Ser Ile Phe Asp
         520                 525                 530

 gac ttt gct cac tac gag aag cgc cag gag gag gag gag gtg gtg cgc     1746
 Asp Phe Ala His Tyr Glu Lys Arg Gln Glu Glu Glu Glu Val Val Arg
     535                 540                 545

 aag gaa cgg cag agt cga aac aaa caa tga g ggcgaaccag tttcttacat     1797
 Lys Glu Arg Gln Ser Arg Asn Lys Gln 
 550                 555

 gttctaacgt ttgactttga aaacagttta aaacacgtgt gcttggtcag ctccagtgtg   1857

 tcgtcccgtg cgggggttga gtgttgcatc tttgcctttc ttgtcgttga tttttgccca   1917

 gatggatctg catttatttg tactttttct atgtattata atcctgtaga agtcactaat   1977

 aaaggagtat tttttttgtc agcttatcaa tcagactgat ctaatgtgaa atgtaagtat   2037

 ccttaaaaac aaagcatcta ttttggcaga aattgtgttc ttaaattcag tcatttgata   2097

 ttctgtgaga cttcatattt ctcatccctt tattgctttt tagcaaacat aagaaaccat   2157

 gagtcatttt gtcatttaga gtattctgat aaaatctctt gaaaatactg aaatcaaaag   2217

 gttaatgatt ttttgttcat tctgatttgt cattttatta tctgttatcg gtctaaagtg   2277

 ctaatttacc catttgattt ttctgctaga cagataactt ttaatttttc aaatttggca   2337

 gacacttttt tttttttttg gaaaattttt ctttcaaaat gggtggccca tggaaaaccc   2397

 accggccctt atg                                                      2410




      <210> 242
      <211> 1198
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (182)..(1198)

      <400> 242
 gcagtgtgct ggaattgatg gacgtagtcg gcacaatgag gaccaggctt gctgtgaagt     60

 ggtgtatgtg gaaggtcgga ggagtgttac aggagtacct agggagccta gccgaggcca    120

 gggactctgc ttctactact ggggcctatt tgatgggcat gcagggggcg gagctgctga    180

 a    atg gcc tca cgg ctc ctg cat cgc cat atc cga gag cag cta aag     226
      Met Ala Ser Arg Leu Leu His Arg His Ile Arg Glu Gln Leu Lys
        1               5                  10                  15

 gac ctg gta gag ata ctt cag gac cct tcg cca cca ccc ctc tgc ctc      274
 Asp Leu Val Glu Ile Leu Gln Asp Pro Ser Pro Pro Pro Leu Cys Leu
                  20                  25                  30

 cca acc act ccg ggg acc cca gat tcc tcc gat ccc tct cac ttg ctt      322
 Pro Thr Thr Pro Gly Thr Pro Asp Ser Ser Asp Pro Ser His Leu Leu
              35                  40                  45

 ggc cct cag tcc tgc tgg tct tca cag aag gaa gtg agc cac gag agc      370
 Gly Pro Gln Ser Cys Trp Ser Ser Gln Lys Glu Val Ser His Glu Ser
          50                  55                  60

 ctg gta gtg ggg gcc att gag aat gcc ttc cag ctc atg gat gag cag      418
 Leu Val Val Gly Ala Ile Glu Asn Ala Phe Gln Leu Met Asp Glu Gln
      65                  70                  75

 atg gcc cgg gag cgg cgt ggc cac caa gtg gag ggg ggc tgc tgt gca      466
 Met Ala Arg Glu Arg Arg Gly His Gln Val Glu Gly Gly Cys Cys Ala
  80                  85                  90                  95

 ctg gtt gtg atc tac ctg cta ggc aag gtg tac gtg gcc aat gca ggc      514
 Leu Val Val Ile Tyr Leu Leu Gly Lys Val Tyr Val Ala Asn Ala Gly
                 100                 105                 110

 gat agc agg gcc atc att gtc cgg aat ggt gaa atc att cca atg tcc      562
 Asp Ser Arg Ala Ile Ile Val Arg Asn Gly Glu Ile Ile Pro Met Ser
             115                 120                 125

 cgg gag ttt acc ccg gag act gag cgc cag cgt ctt cag ctg ctt ggc      610
 Arg Glu Phe Thr Pro Glu Thr Glu Arg Gln Arg Leu Gln Leu Leu Gly
         130                 135                 140

 ttc ctg aaa cca gag ctg cta ggc agt gaa ttc acc cac ctt gag ttc      658
 Phe Leu Lys Pro Glu Leu Leu Gly Ser Glu Phe Thr His Leu Glu Phe
     145                 150                 155

 ccc cgc aga gtt ctg ccc aag gag ctg ggg cag agg atg ttg tac cgg      706
 Pro Arg Arg Val Leu Pro Lys Glu Leu Gly Gln Arg Met Leu Tyr Arg
 160                 165                 170                 175

 gac cag aac atg acc ggc tgg gcc tac aaa aag atc gag ctg gag gat      754
 Asp Gln Asn Met Thr Gly Trp Ala Tyr Lys Lys Ile Glu Leu Glu Asp
                 180                 185                 190

 ctc agg ttt cct ctg gtc tgt ggg gag ggc aaa aag gct cgg gtg atg      802
 Leu Arg Phe Pro Leu Val Cys Gly Glu Gly Lys Lys Ala Arg Val Met
             195                 200                 205

 gcc acc att ggg gtg acc cga ggc ttg gga gac cac agc ctt aag gtc      850
 Ala Thr Ile Gly Val Thr Arg Gly Leu Gly Asp His Ser Leu Lys Val
         210                 215                 220

 tgc agt tcc acc ctg ccc atc aag ccc ttt ctc tcc tgc ttc cct gag      898
 Cys Ser Ser Thr Leu Pro Ile Lys Pro Phe Leu Ser Cys Phe Pro Glu
     225                 230                 235

 gta cga gtg tat gac ctg aca caa tat gag cac tgc cca gat gat gtg      946
 Val Arg Val Tyr Asp Leu Thr Gln Tyr Glu His Cys Pro Asp Asp Val
 240                 245                 250                 255

 cta gtc ctg gga aca gat ggc ctg tgg gat gtc act act gac tgt gag      994
 Leu Val Leu Gly Thr Asp Gly Leu Trp Asp Val Thr Thr Asp Cys Glu
                 260                 265                 270

 gta gct gcc act gtg gac agg gtg ctg tcg gcc tat gag cct aat gac     1042
 Val Ala Ala Thr Val Asp Arg Val Leu Ser Ala Tyr Glu Pro Asn Asp
             275                 280                 285

 cac agc agg tat aca gct ctg gcc caa gct ctg gtc ctg ggg gcc cgg     1090
 His Ser Arg Tyr Thr Ala Leu Ala Gln Ala Leu Val Leu Gly Ala Arg
         290                 295                 300

 ggt acc ccc cga gac cgt ggc tgg cgt ctc ccc aac aac aag ctg ggt     1138
 Gly Thr Pro Arg Asp Arg Gly Trp Arg Leu Pro Asn Asn Lys Leu Gly
     305                 310                 315

 tcc ggg gat gac atc tct gtc ttc gtc atc ccc ctg gga ggg cca ggc     1186
 Ser Gly Asp Asp Ile Ser Val Phe Val Ile Pro Leu Gly Gly Pro Gly
 320                 325                 330                 335

 agt tac tcc tga                                                     1198
 Ser Tyr Ser 






      <210> 243
      <211> 2286
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (72)..(1715)

      <400> 243
 gcagcatctc ctgtgaacac agaggagcac ctgtttgctg ttaaaatcga tctccctcgg     60

 caccctgagc a atg gat ata ata ttt ggc agg aat agg aaa gaa cag ctg     110
              Met Asp Ile Ile Phe Gly Arg Asn Arg Lys Glu Gln Leu
                1               5                  10

 gag cct gtg agg gcc aaa gtg aca ggc aag att cca gca tgg ctg cag      158
 Glu Pro Val Arg Ala Lys Val Thr Gly Lys Ile Pro Ala Trp Leu Gln
      15                  20                  25

 gga acc ctg ctc cgc aat ggg cct ggg atg cac aca gtt ggg gag tcc      206
 Gly Thr Leu Leu Arg Asn Gly Pro Gly Met His Thr Val Gly Glu Ser
  30                  35                  40                  45

 aga tac aac cat tgg ttc gac ggc ctt gcc ctg ctc cac agc ttc acc      254
 Arg Tyr Asn His Trp Phe Asp Gly Leu Ala Leu Leu His Ser Phe Thr
                  50                  55                  60

 atc aga gac ggt gaa gtc tat tac agg agc aaa tac ctg aga agc gat      302
 Ile Arg Asp Gly Glu Val Tyr Tyr Arg Ser Lys Tyr Leu Arg Ser Asp
              65                  70                  75

 acc tac aac acc aat att gag gca aac agg att gtg gtg tct gag ttt      350
 Thr Tyr Asn Thr Asn Ile Glu Ala Asn Arg Ile Val Val Ser Glu Phe
          80                  85                  90

 gga aca atg gcc tat ccg gac ccc tgc aaa aac ata ttt tcc aaa gct      398
 Gly Thr Met Ala Tyr Pro Asp Pro Cys Lys Asn Ile Phe Ser Lys Ala
      95                 100                 105

 ttc tcc tac ttg tct cac acc atc ccc gat ttc aca gac aac tgc ctg      446
 Phe Ser Tyr Leu Ser His Thr Ile Pro Asp Phe Thr Asp Asn Cys Leu
 110                 115                 120                 125

 atc aac atc atg aag tgc gga gaa gac ttc tac gcg acc tca gag acc      494
 Ile Asn Ile Met Lys Cys Gly Glu Asp Phe Tyr Ala Thr Ser Glu Thr
                 130                 135                 140

 aat tac atc agg aaa atc aac cca cag act ctg gaa acc ctg gag aag      542
 Asn Tyr Ile Arg Lys Ile Asn Pro Gln Thr Leu Glu Thr Leu Glu Lys
             145                 150                 155

 gtt gat tat cgt aaa tac gtg gcg gta aat ctg gca acg tca cat ccc      590
 Val Asp Tyr Arg Lys Tyr Val Ala Val Asn Leu Ala Thr Ser His Pro
         160                 165                 170

 cat tat gat gag gct gga aat gtt cta aac atg ggc aca tcc att gtg      638
 His Tyr Asp Glu Ala Gly Asn Val Leu Asn Met Gly Thr Ser Ile Val
     175                 180                 185

 gaa aag ggg aag aca aag tat gtg att ttt aag atc cct gcc aca gta      686
 Glu Lys Gly Lys Thr Lys Tyr Val Ile Phe Lys Ile Pro Ala Thr Val
 190                 195                 200                 205

 cca gag ggc aag aag cag ggg aag agc ccc tgg aag cac aca gag gtg      734
 Pro Glu Gly Lys Lys Gln Gly Lys Ser Pro Trp Lys His Thr Glu Val
                 210                 215                 220

 ttc tgc tcc atc cca tcc cgc tcc ctg ctc tcc cca agc tac tac cac      782
 Phe Cys Ser Ile Pro Ser Arg Ser Leu Leu Ser Pro Ser Tyr Tyr His
             225                 230                 235

 agc ttt gga gtc acc gag aac tat gtc atc ttc ctt gag cag cct ttc      830
 Ser Phe Gly Val Thr Glu Asn Tyr Val Ile Phe Leu Glu Gln Pro Phe
         240                 245                 250

 agg ttg gat att ctc aag atg gca acc gca tac atc cgg aga atg agc      878
 Arg Leu Asp Ile Leu Lys Met Ala Thr Ala Tyr Ile Arg Arg Met Ser
     255                 260                 265

 tgg gcc tcc tgc ctg gct ttc cac agg gag gag aag act tat atc cac      926
 Trp Ala Ser Cys Leu Ala Phe His Arg Glu Glu Lys Thr Tyr Ile His
 270                 275                 280                 285

 atc atc gac caa agg acc agg cag cct gtg cag acc aag ttt tac aca      974
 Ile Ile Asp Gln Arg Thr Arg Gln Pro Val Gln Thr Lys Phe Tyr Thr
                 290                 295                 300

 gac gcc atg gtg gtc ttc cat cac gtc aac gcc tac gaa gag gac ggc     1022
 Asp Ala Met Val Val Phe His His Val Asn Ala Tyr Glu Glu Asp Gly
             305                 310                 315

 tgc atc gtg ttt gac gtc att gcc tac gag gac aac agc ctc tac cag     1070
 Cys Ile Val Phe Asp Val Ile Ala Tyr Glu Asp Asn Ser Leu Tyr Gln
         320                 325                 330

 ctc ttc tac ctg gcc aac ctg aac cag gac ttc aag gag aac tcc agg     1118
 Leu Phe Tyr Leu Ala Asn Leu Asn Gln Asp Phe Lys Glu Asn Ser Arg
     335                 340                 345

 ctc acc tcg gtc ccc acc ctc agg agg ttt gcc gtg ccc ctc cac gtg     1166
 Leu Thr Ser Val Pro Thr Leu Arg Arg Phe Ala Val Pro Leu His Val
 350                 355                 360                 365

 gac aag aat gca gaa gtg ggc aca aat tta atc aaa gtg gca tct aca     1214
 Asp Lys Asn Ala Glu Val Gly Thr Asn Leu Ile Lys Val Ala Ser Thr
                 370                 375                 380

 aca gcc acg gcc ctg aag gaa gaa gat ggc caa gtc tac tgc cag ccg     1262
 Thr Ala Thr Ala Leu Lys Glu Glu Asp Gly Gln Val Tyr Cys Gln Pro
             385                 390                 395

 gaa ttt ctt tat gaa ggc tta gag ctt cca cgg gtc aat tat gct cac     1310
 Glu Phe Leu Tyr Glu Gly Leu Glu Leu Pro Arg Val Asn Tyr Ala His
         400                 405                 410

 aat gga aag caa tac cga tat gtc ttt gct aca gga gtt cag tgg agt     1358
 Asn Gly Lys Gln Tyr Arg Tyr Val Phe Ala Thr Gly Val Gln Trp Ser
     415                 420                 425

 cca atc cca acc aag ata ata aaa tat gac att ctc aca aag tca tcc     1406
 Pro Ile Pro Thr Lys Ile Ile Lys Tyr Asp Ile Leu Thr Lys Ser Ser
 430                 435                 440                 445

 tta aaa tgg aga gag gac gac tgc tgg cca gcg gaa ccc ctg ttt gtg     1454
 Leu Lys Trp Arg Glu Asp Asp Cys Trp Pro Ala Glu Pro Leu Phe Val
                 450                 455                 460

 ccc gcg cca ggt gcc aag gat gag gat gac gga gta atc tta tca gcc     1502
 Pro Ala Pro Gly Ala Lys Asp Glu Asp Asp Gly Val Ile Leu Ser Ala
             465                 470                 475

 att gtc tct act gat ccc caa aag ctg cct ttt ctg ctc att ctg gat     1550
 Ile Val Ser Thr Asp Pro Gln Lys Leu Pro Phe Leu Leu Ile Leu Asp
         480                 485                 490

 gcc aaa agc ttt acg gaa ttg gcc cgt gcc tct gtt gat gtc gat atg     1598
 Ala Lys Ser Phe Thr Glu Leu Ala Arg Ala Ser Val Asp Val Asp Met
     495                 500                 505

 cac atg gat ctc cat gga tta ttc att aca gac atg gac tgg gac aca     1646
 His Met Asp Leu His Gly Leu Phe Ile Thr Asp Met Asp Trp Asp Thr
 510                 515                 520                 525

 aaa aag cag gcc gct tct gag gaa cag cgg gac agg gct tcc gac tgc     1694
 Lys Lys Gln Ala Ala Ser Glu Glu Gln Arg Asp Arg Ala Ser Asp Cys
                 530                 535                 540

 cac ggg gct cct ctg acc tga tg gtgttggggt ttgggtaggg gaggggagct     1747
 His Gly Ala Pro Leu Thr 
             545

 cggctgtcag aactccatgg atatgtttct ttggatggag gggagggcct ttgttacctt   1807

 ttgcacttat tctttctgtg ggtgctttga caagggcatg gcaagagagc ttgtcagtat   1867

 catttctttc attttatttt ggctgcaaaa attttgtttg aaagtcaaac atttgaacat   1927

 caaatatgta ttgattagat ccagtccttc taagaaacct cctttccttt aacaaaaaga   1987

 ccttgaccat gaatcagaga ttgtattcaa tgacattatc atcattttta gaacgagcca   2047

 ctaacctatt agagaagagg cagataatta tttatcattg tgccttcctc tgtctctttc   2107

 tctttccttt gctccctccc atgtttctgg tggactaaat tgtgtatctg ggagttctca   2167

 ctttctagcc aggcctgatg agttaagtta catgaccagg aaggttatgc cactttgtgg   2227

 tcattccatg caagtcatgg cgtaatataa aataataaaa actttaaaaa aaaaaaaaa    2286




      <210> 244
      <211> 886
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (28)..(735)

      <400> 244
 aggaggcaga actctgggtg tctcacc    atg gcc tgg atc cct cta ctt ctc      51
                                  Met Ala Trp Ile Pro Leu Leu Leu
                                    1               5

 ccc ctc ctc act ctc tgc aca ggc tct gag gcc tcc tat gag ctg aca       99
 Pro Leu Leu Thr Leu Cys Thr Gly Ser Glu Ala Ser Tyr Glu Leu Thr
      10                  15                  20

 cag cca ccc tcg gtg tca gtg tcc cca gga cag acg gcc agg atc acc      147
 Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln Thr Ala Arg Ile Thr
  25                  30                  35                  40

 tgc tct gga gat gca ttg cca aag caa tat gct tat tgg tac cag cag      195
 Cys Ser Gly Asp Ala Leu Pro Lys Gln Tyr Ala Tyr Trp Tyr Gln Gln
                  45                  50                  55

 aag cca ggc cag gcc cct gtg ctg gtg ata tat aaa gac agt gag agg      243
 Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Lys Asp Ser Glu Arg
              60                  65                  70

 ccc tca ggg atc cct gag cga ttc tct ggc tcc agc tca ggg aca aca      291
 Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Ser Ser Gly Thr Thr
          75                  80                  85

 gtc acg ttg acc atc agt gga gtc cag gca gaa gac gag gct gac tat      339
 Val Thr Leu Thr Ile Ser Gly Val Gln Ala Glu Asp Glu Ala Asp Tyr
      90                  95                 100

 tac tgt caa tca gca gac agc agt ggt act tat cca ggg tat gtc ttc      387
 Tyr Cys Gln Ser Ala Asp Ser Ser Gly Thr Tyr Pro Gly Tyr Val Phe
 105                 110                 115                 120

 gga act ggg acc aag gtc acc gtc cta ggt cag ccc aag gcc aac ccc      435
 Gly Thr Gly Thr Lys Val Thr Val Leu Gly Gln Pro Lys Ala Asn Pro
                 125                 130                 135

 act gtc act ctg ttc cag ccc tcc tct gag gag ctc caa gcc aac aag      483
 Thr Val Thr Leu Phe Gln Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys
             140                 145                 150

 gcc aca cta gtg tgt ctg atc agt gac ttc tac ccg gga gct gtg aca      531
 Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr
         155                 160                 165

 gtg gcc tgg aag gca gat ggc agc ccc gtc aag gcg gga gtg gag acc      579
 Val Ala Trp Lys Ala Asp Gly Ser Pro Val Lys Ala Gly Val Glu Thr
     170                 175                 180

 acc aaa ccc tcc aaa cag agc aac aac aag tac gcg gcc agc agc tac      627
 Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr
 185                 190                 195                 200

 ctg agc ctg acg ccc gag cag tgg aag tcc cac aga agc tac agc tgc      675
 Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr Ser Cys
                 205                 210                 215

 cag gtc acg cat gaa ggg agc acc gtg gag aag aca gtg gcc cct aca      723
 Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro Thr
             220                 225                 230

 gaa tgt tca tag gtt cccaactcta accccaccca cgggagcctg gagctgcagg      778
 Glu Cys Ser 
         235

 atcccagggg aggggtctct ctccccatcc caagtcatcc agcccttctc cctgcactca    838

 tgaaacccca ataaatatcc tcattgacaa ccagaaaaaa aaaaaaaa                 886




      <210> 245
      <211> 1943
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (111)..(1943)

      <400> 245
 tgcggttcct ctaggaaaat tcctttgtgc agatcaggcc cgtggattgg gatctgtgaa     60

 caagaggaac ctcagcagcc aggacaggca ggagcagtgg aatagctact   atg gct     116
                                                          Met Ala
                                                            1

 tct gga atc ctg gtt aat gta aag gag gag gtg acc tgc ccc atc tgc      164
 Ser Gly Ile Leu Val Asn Val Lys Glu Glu Val Thr Cys Pro Ile Cys
           5                  10                  15

 ctg gaa ctc ctg aca caa ccc ctg agc ctg gac tgc ggc cac agc ttc      212
 Leu Glu Leu Leu Thr Gln Pro Leu Ser Leu Asp Cys Gly His Ser Phe
      20                  25                  30

 tgc caa gca tgc ctc act gca aac cac aag aag tcc atg cta gac aaa      260
 Cys Gln Ala Cys Leu Thr Ala Asn His Lys Lys Ser Met Leu Asp Lys
  35                  40                  45                  50

 gga gag agt agc tgc cct gtg tgc cgg atc agt tac cag cct gag aac      308
 Gly Glu Ser Ser Cys Pro Val Cys Arg Ile Ser Tyr Gln Pro Glu Asn
                  55                  60                  65

 ata cgg cct aat cgg cat gta gcc aac ata gtg gag aag ctc agg gag      356
 Ile Arg Pro Asn Arg His Val Ala Asn Ile Val Glu Lys Leu Arg Glu
              70                  75                  80

 gtc aag ttg agc cca gag ggg cag aaa gtt gat cat tgt gca cgc cat      404
 Val Lys Leu Ser Pro Glu Gly Gln Lys Val Asp His Cys Ala Arg His
          85                  90                  95

 gga gag aaa ctt cta ctc ttc tgt cag gag gac ggg aag gtc att tgc      452
 Gly Glu Lys Leu Leu Leu Phe Cys Gln Glu Asp Gly Lys Val Ile Cys
     100                 105                 110

 tgg ctt tgt gag cgg tct cag gag cac cgt ggt cac cac acg ttc ctc      500
 Trp Leu Cys Glu Arg Ser Gln Glu His Arg Gly His His Thr Phe Leu
 115                 120                 125                 130

 aca gag gag gtt gcc cgg gag tac caa gtg aag ctc cag gca gct ctg      548
 Thr Glu Glu Val Ala Arg Glu Tyr Gln Val Lys Leu Gln Ala Ala Leu
                 135                 140                 145

 gag atg ctg agg cag aag cag cag gaa gct gaa gag ttg gaa gct gac      596
 Glu Met Leu Arg Gln Lys Gln Gln Glu Ala Glu Glu Leu Glu Ala Asp
             150                 155                 160

 atc aga gaa gag aaa gct tcc tgg aag act caa ata cag tat gac aaa      644
 Ile Arg Glu Glu Lys Ala Ser Trp Lys Thr Gln Ile Gln Tyr Asp Lys
         165                 170                 175

 acc aac gtc ttg gca gat ttt gag caa ctg aga gac atc ctg gac tgg      692
 Thr Asn Val Leu Ala Asp Phe Glu Gln Leu Arg Asp Ile Leu Asp Trp
     180                 185                 190

 gag gag agc aat gag ctg caa aac ctg gag aag gag gag gaa gac att      740
 Glu Glu Ser Asn Glu Leu Gln Asn Leu Glu Lys Glu Glu Glu Asp Ile
 195                 200                 205                 210

 ctg aaa agc ctt acg aac tct gaa act gag atg gtg cag cag acc cag      788
 Leu Lys Ser Leu Thr Asn Ser Glu Thr Glu Met Val Gln Gln Thr Gln
                 215                 220                 225

 tcc ctg agg gag ctc atc tca gat ctg gag cat cgg ctg cag ggg tca      836
 Ser Leu Arg Glu Leu Ile Ser Asp Leu Glu His Arg Leu Gln Gly Ser
             230                 235                 240

 gtg atg gag ctg ctt cag gct cag gga gaa ggg ttc aag tgc atc agt      884
 Val Met Glu Leu Leu Gln Ala Gln Gly Glu Gly Phe Lys Cys Ile Ser
         245                 250                 255

 gat gtg aag gag atg aaa cca gtg atg tgg gag gga tgg aca cag gat      932
 Asp Val Lys Glu Met Lys Pro Val Met Trp Glu Gly Trp Thr Gln Asp
     260                 265                 270

 gag aga tgt ggg ggt caa aaa att ttt ttc atc cct agg agt gag atc      980
 Glu Arg Cys Gly Gly Gln Lys Ile Phe Phe Ile Pro Arg Ser Glu Ile
 275                 280                 285                 290

 tgg agg ctg aaa aag cca aaa atg gtt tcc aag aaa ctg aag act gta     1028
 Trp Arg Leu Lys Lys Pro Lys Met Val Ser Lys Lys Leu Lys Thr Val
                 295                 300                 305

 ttc cat gct cca gat ctg agt agg atg ctg caa atg ttt aga ggt gag     1076
 Phe His Ala Pro Asp Leu Ser Arg Met Leu Gln Met Phe Arg Gly Glu
             310                 315                 320

 gag aag cag aca aag act gtg gat gtg gga ttg ttg tgg tgt cag gct     1124
 Glu Lys Gln Thr Lys Thr Val Asp Val Gly Leu Leu Trp Cys Gln Ala
         325                 330                 335

 gtg gtt gtt agt gga ggc tat ggt aag gct ttg ctg ggg atg tca ggc     1172
 Val Val Val Ser Gly Gly Tyr Gly Lys Ala Leu Leu Gly Met Ser Gly
     340                 345                 350

 agg atg ttc ctt gtg acc ctg ggg agc acg tgt gag tac cag tgg tgg     1220
 Arg Met Phe Leu Val Thr Leu Gly Ser Thr Cys Glu Tyr Gln Trp Trp
 355                 360                 365                 370

 tgc cag ggg cca ggc atg cta gtc ttc gaa cac ctg ggc agc ata cat     1268
 Cys Gln Gly Pro Gly Met Leu Val Phe Glu His Leu Gly Ser Ile His
                 375                 380                 385

 ggg agc tgg tgg tgg cag atg tgg gta agt gtt ctt gat gag ggt ggg     1316
 Gly Ser Trp Trp Trp Gln Met Trp Val Ser Val Leu Asp Glu Gly Gly
             390                 395                 400

 ctt tat gtt cat att ctg ggc cac cct tct ttc ttc att ctc caa gga     1364
 Leu Tyr Val His Ile Leu Gly His Pro Ser Phe Phe Ile Leu Gln Gly
         405                 410                 415

 att cct ggc atg gag gac aaa cac aga tgg ata tct atc ccc ttc tcc     1412
 Ile Pro Gly Met Glu Asp Lys His Arg Trp Ile Ser Ile Pro Phe Ser
     420                 425                 430

 tcc atg tat ttc att atg gtg ctt ggg aac tgc acc atc ctc ctc acc     1460
 Ser Met Tyr Phe Ile Met Val Leu Gly Asn Cys Thr Ile Leu Leu Thr
 435                 440                 445                 450

 atc tcc aca gag cgc tcc ctg cac aaa ccc atg ttc ctg ctc ctc tgt     1508
 Ile Ser Thr Glu Arg Ser Leu His Lys Pro Met Phe Leu Leu Leu Cys
                 455                 460                 465

 ctg ttg gcc ctc aca gac ctg ggc atg tct aca acc acc att ccc aag     1556
 Leu Leu Ala Leu Thr Asp Leu Gly Met Ser Thr Thr Thr Ile Pro Lys
             470                 475                 480

 gtg ctg tgc att ttc tgg ttt ggc cag agt gag atc agc tat gaa gga     1604
 Val Leu Cys Ile Phe Trp Phe Gly Gln Ser Glu Ile Ser Tyr Glu Gly
         485                 490                 495

 tgc ctg gtt cag ctg ttc ttc atc cac tcc atc tct gcc atg cag tca     1652
 Cys Leu Val Gln Leu Phe Phe Ile His Ser Ile Ser Ala Met Gln Ser
     500                 505                 510

 gct gtc ctg atg acc atg gcc ttt gac cac tat gtg gcc atc tgc aag     1700
 Ala Val Leu Met Thr Met Ala Phe Asp His Tyr Val Ala Ile Cys Lys
 515                 520                 525                 530

 ccc ttg cgc tat gcc acc atc ctt tcc aat agt tgc act gga ctc att     1748
 Pro Leu Arg Tyr Ala Thr Ile Leu Ser Asn Ser Cys Thr Gly Leu Ile
                 535                 540                 545

 ggc tta gtg agt ttg gtg aga gct atc ctc ttt att ctc ccc atg ccc     1796
 Gly Leu Val Ser Leu Val Arg Ala Ile Leu Phe Ile Leu Pro Met Pro
             550                 555                 560

 atc ctc ctt cag caa atg ccc tat cat gcc aat cgt gtc atc ccc acc     1844
 Ile Leu Leu Gln Gln Met Pro Tyr His Ala Asn Arg Val Ile Pro Thr
         565                 570                 575

 acc tcc tgt gag cac atg gct gtg gtg aag atg gtt tgt gta gat act     1892
 Thr Ser Cys Glu His Met Ala Val Val Lys Met Val Cys Val Asp Thr
     580                 585                 590

 aca gtc aac agg ata tat ggc ctg gtg gtg gcc ttg ttg gtt gct ggc     1940
 Thr Val Asn Arg Ile Tyr Gly Leu Val Val Ala Leu Leu Val Ala Gly
 595                 600                 605                 610

 tag                                                                 1943
 




      <210> 246
      <211> 375
      <212> PRT
      <213> Homo sapiens


      <400> 246
 Met Asp Arg Ser Leu Arg Asn Val Leu Val Val Ser Phe Gly Phe Leu
   1               5                  10                  15    
 Leu Leu Phe Thr Ala Tyr Gly Gly Leu Gln Ser Leu Gln Ser Ser Leu
              20                  25                  30        
 Tyr Ser Glu Glu Gly Leu Gly Val Thr Ala Leu Ser Thr Leu Tyr Gly
          35                  40                  45            
 Gly Met Leu Leu Ser Ser Met Phe Leu Pro Pro Leu Leu Ile Glu Arg
      50                  55                  60                
 Leu Gly Cys Lys Gly Thr Ile Ile Leu Ser Met Cys Gly Tyr Val Ala
  65                  70                  75                  80
 Phe Ser Val Gly Asn Phe Phe Ala Ser Trp Tyr Thr Leu Ile Pro Thr
                  85                  90                  95    
 Ser Ile Leu Leu Gly Leu Gly Ala Ala Pro Leu Trp Ser Ala Gln Cys
             100                 105                 110        
 Thr Tyr Leu Thr Ile Thr Gly Asn Thr His Ala Glu Lys Ala Gly Lys
         115                 120                 125            
 Arg Gly Lys Asp Met Val Asn Gln Tyr Phe Gly Ile Phe Phe Leu Ile
     130                 135                 140                
 Phe Gln Ser Ser Gly Val Trp Gly Asn Leu Ile Ser Ser Leu Val Phe
 145                 150                 155                 160
 Gly Gln Thr Pro Ser Gln Glu Thr Leu Pro Glu Glu Gln Leu Thr Ser
                 165                 170                 175    
 Cys Gly Ala Ser Asp Cys Leu Met Ala Thr Thr Thr Thr Asn Ser Thr
             180                 185                 190        
 Gln Arg Pro Ser Gln Gln Leu Val Tyr Thr Leu Leu Gly Ile Tyr Thr
         195                 200                 205            
 Gly Ser Gly Val Leu Ala Val Leu Met Ile Ala Ala Phe Leu Gln Pro
     210                 215                 220                
 Ile Arg Asp Val Gln Arg Glu Ser Glu Gly Glu Lys Lys Ser Val Pro
 225                 230                 235                 240
 Phe Trp Ser Thr Leu Leu Ser Thr Phe Lys Leu Tyr Arg Asp Lys Arg
                 245                 250                 255    
 Leu Cys Leu Leu Ile Leu Leu Pro Leu Tyr Ser Gly Leu Gln Gln Gly
             260                 265                 270        
 Phe Leu Ser Ser Glu Tyr Thr Arg Ser Tyr Val Thr Cys Thr Leu Gly
         275                 280                 285            
 Ile Gln Phe Val Gly Tyr Val Met Ile Cys Phe Ser Ala Thr Asp Ala
     290                 295                 300                
 Leu Cys Ser Val Leu Tyr Gly Lys Val Ser Gln Tyr Thr Gly Arg Ala
 305                 310                 315                 320
 Val Leu Tyr Val Leu Gly Ala Val Thr His Val Ser Cys Met Ile Ala
                 325                 330                 335    
 Leu Leu Leu Trp Arg Pro Arg Ala Asp His Leu Ala Val Val Phe Val
             340                 345                 350        
 Phe Ser Gly Leu Trp Gly Val Ala Asp Ala Ala Ala Asp Thr Lys Gln
         355                 360                 365            
 Cys Ser Leu Arg Arg Ser Val
     370                 375



      <210> 247
      <211> 737
      <212> PRT
      <213> Homo sapiens


      <400> 247
 Met Asn Gly Asp Ser Arg Ala Ala Val Val Thr Ser Pro Pro Pro Thr
   1               5                  10                  15    
 Thr Ala Pro His Lys Glu Arg Tyr Phe Asp Arg Val Asp Glu Asn Asn
              20                  25                  30        
 Pro Glu Tyr Leu Arg Glu Arg Asn Met Ala Pro Asp Leu Arg Gln Asp
          35                  40                  45            
 Phe Asn Met Met Glu Gln Lys Lys Arg Val Ser Met Ile Leu Gln Ser
      50                  55                  60                
 Pro Ala Phe Cys Glu Glu Leu Glu Ser Met Ile Gln Glu Gln Phe Lys
  65                  70                  75                  80
 Lys Gly Lys Asn Pro Thr Gly Leu Leu Ala Leu Gln Gln Ile Ala Asp
                  85                  90                  95    
 Phe Met Thr Thr Asn Val Pro Asn Val Tyr Pro Ala Ala Pro Gln Gly
             100                 105                 110        
 Gly Met Ala Ala Leu Asn Met Ser Leu Gly Met Val Thr Pro Val Asn
         115                 120                 125            
 Asp Leu Arg Gly Ser Asp Ser Ile Ala Tyr Asp Lys Gly Glu Lys Leu
     130                 135                 140                
 Leu Arg Cys Lys Leu Ala Ala Phe Tyr Arg Leu Ala Asp Leu Phe Gly
 145                 150                 155                 160
 Trp Ser Gln Leu Ile Tyr Asn His Ile Thr Thr Arg Val Asn Ser Glu
                 165                 170                 175    
 Gln Glu His Phe Leu Ile Val Pro Phe Gly Leu Leu Tyr Ser Glu Val
             180                 185                 190        
 Thr Ala Ser Ser Leu Val Lys Ile Asn Leu Gln Gly Asp Ile Val Asp
         195                 200                 205            
 Arg Gly Ser Thr Asn Leu Gly Val Asn Gln Ala Gly Phe Thr Leu His
     210                 215                 220                
 Ser Ala Ile Tyr Ala Ala Arg Pro Asp Val Lys Cys Val Val His Ile
 225                 230                 235                 240
 His Thr Pro Ala Gly Ala Ala Val Ser Ala Met Lys Cys Gly Leu Leu
                 245                 250                 255    
 Pro Ile Ser Pro Glu Ala Leu Ser Leu Gly Glu Val Ala Tyr His Asp
             260                 265                 270        
 Tyr His Gly Ile Leu Val Asp Glu Glu Glu Lys Val Leu Ile Gln Lys
         275                 280                 285            
 Asn Leu Gly Pro Lys Ser Lys Val Leu Ile Leu Arg Asn His Gly Leu
     290                 295                 300                
 Val Ser Val Gly Glu Ser Val Glu Glu Ala Phe Tyr Tyr Ile His Asn
 305                 310                 315                 320
 Leu Val Val Ala Cys Glu Ile Gln Val Arg Thr Leu Ala Ser Ala Gly
                 325                 330                 335    
 Gly Pro Asp Asn Leu Val Leu Leu Asn Pro Glu Lys Tyr Lys Ala Lys
             340                 345                 350        
 Ser Arg Ser Pro Gly Ser Pro Val Gly Glu Gly Thr Gly Ser Pro Pro
         355                 360                 365            
 Lys Trp Gln Ile Gly Glu Gln Glu Phe Glu Ala Leu Met Arg Met Leu
     370                 375                 380                
 Asp Asn Leu Gly Tyr Arg Thr Gly Tyr Pro Tyr Arg Tyr Pro Ala Leu
 385                 390                 395                 400
 Arg Glu Lys Ser Lys Lys Tyr Ser Asp Val Glu Val Pro Ala Ser Val
                 405                 410                 415    
 Thr Gly Tyr Ser Phe Ala Ser Asp Gly Asp Ser Gly Thr Cys Ser Pro
             420                 425                 430        
 Leu Arg His Ser Phe Gln Lys Gln Gln Arg Glu Lys Thr Arg Trp Leu
         435                 440                 445            
 Asn Ser Gly Arg Gly Asp Glu Ala Ser Glu Glu Trp Gln Asn Gly Ser
     450                 455                 460                
 Ser Pro Lys Ser Lys Thr Lys Trp Thr Lys Glu Asp Gly His Arg Thr
 465                 470                 475                 480
 Ser Thr Ser Ala Val Pro Asn Leu Phe Val Pro Leu Asn Thr Asn Pro
                 485                 490                 495    
 Lys Glu Val Gln Glu Met Arg Asn Lys Ile Arg Glu Gln Asn Leu Gln
             500                 505                 510        
 Asp Ile Lys Thr Ala Gly Pro Gln Ser Gln Val Leu Cys Gly Val Val
         515                 520                 525            
 Met Asp Arg Ser Leu Val Gln Gly Glu Leu Val Thr Ala Ser Lys Ala
     530                 535                 540                
 Ile Ile Glu Lys Glu Tyr Gln Pro His Val Ile Val Ser Thr Thr Gly
 545                 550                 555                 560
 Pro Asn Pro Phe Thr Thr Leu Thr Asp Arg Glu Leu Glu Glu Tyr Arg
                 565                 570                 575    
 Arg Glu Val Glu Arg Lys Gln Lys Gly Ser Glu Glu Asn Leu Asp Glu
             580                 585                 590        
 Ala Arg Glu Gln Lys Glu Lys Ser Pro Pro Asp Gln Pro Ala Val Pro
         595                 600                 605            
 His Pro Pro Pro Ser Thr Pro Ile Lys Leu Glu Glu Asp Leu Val Pro
     610                 615                 620                
 Glu Pro Thr Thr Gly Asp Asp Ser Asp Ala Ala Thr Phe Lys Pro Thr
 625                 630                 635                 640
 Leu Pro Asp Leu Ser Pro Asp Glu Pro Ser Glu Ala Leu Gly Phe Pro
                 645                 650                 655    
 Met Leu Glu Lys Glu Glu Glu Ala His Arg Pro Pro Ser Pro Thr Glu
             660                 665                 670        
 Ala Pro Thr Glu Ala Ser Pro Glu Pro Ala Pro Asp Pro Ala Pro Val
         675                 680                 685            
 Ala Glu Glu Ala Ala Pro Ser Ala Val Glu Glu Gly Ala Ala Ala Asp
     690                 695                 700                
 Pro Gly Ser Asp Gly Ser Pro Gly Lys Ser Pro Ser Lys Lys Lys Lys
 705                 710                 715                 720
 Lys Phe Arg Thr Pro Ser Phe Leu Lys Lys Ser Lys Lys Lys Ser Asp
                 725                 730                 735    
 Ser
    



      <210> 248
      <211> 768
      <212> PRT
      <213> Homo sapiens


      <400> 248
 Met Asn Gly Asp Ser Arg Ala Ala Val Val Thr Ser Pro Pro Pro Thr
   1               5                  10                  15    
 Thr Ala Pro His Lys Glu Arg Tyr Phe Asp Arg Val Asp Glu Asn Asn
              20                  25                  30        
 Pro Glu Tyr Leu Arg Glu Arg Asn Met Ala Pro Asp Leu Arg Gln Asp
          35                  40                  45            
 Phe Asn Met Met Glu Gln Lys Lys Arg Val Ser Met Ile Leu Gln Ser
      50                  55                  60                
 Pro Ala Phe Cys Glu Glu Leu Glu Ser Met Ile Gln Glu Gln Phe Lys
  65                  70                  75                  80
 Lys Gly Lys Asn Pro Thr Gly Leu Leu Ala Leu Gln Gln Ile Ala Asp
                  85                  90                  95    
 Phe Met Thr Thr Asn Val Pro Asn Val Tyr Pro Ala Ala Pro Gln Gly
             100                 105                 110        
 Gly Met Ala Ala Leu Asn Met Ser Leu Gly Met Val Thr Pro Val Asn
         115                 120                 125            
 Asp Leu Arg Gly Ser Asp Ser Ile Ala Tyr Asp Lys Gly Glu Lys Leu
     130                 135                 140                
 Leu Arg Cys Lys Leu Ala Ala Phe Tyr Arg Leu Ala Asp Leu Phe Gly
 145                 150                 155                 160
 Trp Ser Gln Leu Ile Tyr Asn His Ile Thr Thr Arg Val Asn Ser Glu
                 165                 170                 175    
 Gln Glu His Phe Leu Ile Val Pro Phe Gly Leu Leu Tyr Ser Glu Val
             180                 185                 190        
 Thr Ala Ser Ser Leu Val Lys Ile Asn Leu Gln Gly Asp Ile Val Asp
         195                 200                 205            
 Arg Gly Ser Thr Asn Leu Gly Val Asn Gln Ala Gly Phe Thr Leu His
     210                 215                 220                
 Ser Ala Ile Tyr Ala Ala Arg Pro Asp Val Lys Cys Val Val His Ile
 225                 230                 235                 240
 His Thr Pro Ala Gly Ala Ala Val Ser Ala Met Lys Cys Gly Leu Leu
                 245                 250                 255    
 Pro Ile Ser Pro Glu Ala Leu Ser Leu Gly Glu Val Ala Tyr His Asp
             260                 265                 270        
 Tyr His Gly Ile Leu Val Asp Glu Glu Glu Lys Val Leu Ile Gln Lys
         275                 280                 285            
 Asn Leu Gly Pro Lys Ser Lys Val Leu Ile Leu Arg Asn His Gly Leu
     290                 295                 300                
 Val Ser Val Gly Glu Ser Val Glu Glu Ala Phe Tyr Tyr Ile His Asn
 305                 310                 315                 320
 Leu Val Val Ala Cys Glu Ile Gln Val Arg Thr Leu Ala Ser Ala Gly
                 325                 330                 335    
 Gly Pro Asp Asn Leu Val Leu Leu Asn Pro Glu Lys Tyr Lys Ala Lys
             340                 345                 350        
 Ser Arg Ser Pro Gly Ser Pro Val Gly Glu Gly Thr Gly Ser Pro Pro
         355                 360                 365            
 Lys Trp Gln Ile Gly Glu Gln Glu Phe Glu Ala Leu Met Arg Met Leu
     370                 375                 380                
 Asp Asn Leu Gly Tyr Arg Thr Gly Tyr Pro Tyr Arg Tyr Pro Ala Leu
 385                 390                 395                 400
 Arg Glu Lys Ser Lys Lys Tyr Ser Asp Val Glu Val Pro Ala Ser Val
                 405                 410                 415    
 Thr Gly Tyr Ser Phe Ala Ser Asp Gly Asp Ser Gly Thr Cys Ser Pro
             420                 425                 430        
 Leu Arg His Ser Phe Gln Lys Gln Gln Arg Glu Lys Thr Arg Trp Leu
         435                 440                 445            
 Asn Ser Gly Arg Gly Asp Glu Ala Ser Glu Glu Trp Gln Asn Gly Ser
     450                 455                 460                
 Ser Pro Lys Ser Lys Thr Lys Val Trp Thr Asn Ile Thr His Asp His
 465                 470                 475                 480
 Val Lys Pro Leu Leu Gln Ser Leu Ser Ser Gly Val Cys Val Pro Ser
                 485                 490                 495    
 Cys Ile Thr Asn Cys Leu Trp Thr Lys Glu Asp Gly His Arg Thr Ser
             500                 505                 510        
 Thr Ser Ala Val Pro Asn Leu Phe Val Pro Leu Asn Thr Asn Pro Lys
         515                 520                 525            
 Glu Val Gln Glu Met Arg Asn Lys Ile Arg Glu Gln Asn Leu Gln Asp
     530                 535                 540                
 Ile Lys Thr Ala Gly Pro Gln Ser Gln Val Leu Cys Gly Val Val Met
 545                 550                 555                 560
 Asp Arg Ser Leu Val Gln Gly Glu Leu Val Thr Ala Ser Lys Ala Ile
                 565                 570                 575    
 Ile Glu Lys Glu Tyr Gln Pro His Val Ile Val Ser Thr Thr Gly Pro
             580                 585                 590        
 Asn Pro Phe Thr Thr Leu Thr Asp Arg Glu Leu Glu Glu Tyr Arg Arg
         595                 600                 605            
 Glu Val Glu Arg Lys Gln Lys Gly Ser Glu Glu Asn Leu Asp Glu Ala
     610                 615                 620                
 Arg Glu Gln Lys Glu Lys Ser Pro Pro Asp Gln Pro Ala Val Pro His
 625                 630                 635                 640
 Pro Pro Pro Ser Thr Pro Ile Lys Leu Glu Glu Asp Leu Val Pro Glu
                 645                 650                 655    
 Pro Thr Thr Gly Asp Asp Ser Asp Ala Ala Thr Phe Lys Pro Thr Leu
             660                 665                 670        
 Pro Asp Leu Ser Pro Asp Glu Pro Ser Glu Ala Leu Gly Phe Pro Met
         675                 680                 685            
 Leu Glu Lys Glu Glu Glu Ala His Arg Pro Pro Ser Pro Thr Glu Ala
     690                 695                 700                
 Pro Thr Glu Ala Ser Pro Glu Pro Ala Pro Asp Pro Ala Pro Val Ala
 705                 710                 715                 720
 Glu Glu Ala Ala Pro Ser Ala Val Glu Glu Gly Ala Ala Ala Asp Pro
                 725                 730                 735    
 Gly Ser Asp Gly Ser Pro Gly Lys Ser Pro Ser Lys Lys Lys Lys Lys
             740                 745                 750        
 Phe Arg Thr Pro Ser Phe Leu Lys Lys Ser Lys Lys Lys Ser Asp Ser
         755                 760                 765            





      <210> 249
      <211> 407
      <212> PRT
      <213> Homo sapiens


      <400> 249
 Met Ala Ala Pro Glu Gln Pro Leu Ala Ile Ser Arg Gly Cys Thr Ser
   1               5                  10                  15    
 Ser Ser Ser Leu Ser Pro Pro Arg Gly Asp Arg Thr Leu Leu Val Arg
              20                  25                  30        
 His Leu Pro Ala Glu Leu Thr Ala Glu Glu Lys Glu Asp Leu Leu Lys
          35                  40                  45            
 Tyr Phe Gly Ala Gln Ser Val Arg Val Leu Ser Asp Lys Gly Arg Leu
      50                  55                  60                
 Lys His Thr Ala Phe Ala Thr Phe Pro Asn Glu Lys Ala Ala Ile Lys
  65                  70                  75                  80
 Ala Leu Thr Arg Leu His Gln Leu Lys Leu Leu Gly His Thr Leu Val
                  85                  90                  95    
 Val Glu Phe Ala Lys Glu Gln Asp Arg Val His Ser Pro Cys Pro Thr
             100                 105                 110        
 Ser Gly Ser Glu Lys Lys Lys Arg Ser Asp Asp Pro Val Glu Asp Asp
         115                 120                 125            
 Lys Glu Lys Lys Glu Leu Gly Tyr Leu Thr Val Glu Asn Gly Ile Ala
     130                 135                 140                
 Pro Asn His Gly Leu Thr Phe Pro Leu Asn Ser Cys Leu Lys Tyr Met
 145                 150                 155                 160
 Tyr Pro Pro Pro Ser Ser Thr Ile Leu Ala Asn Ile Val Asn Ala Leu
                 165                 170                 175    
 Ala Ser Val Pro Lys Phe Tyr Val Gln Val Leu His Leu Met Asn Lys
             180                 185                 190        
 Met Asn Leu Pro Thr Pro Phe Gly Pro Ile Thr Ala Arg Pro Pro Met
         195                 200                 205            
 Tyr Glu Asp Tyr Met Pro Leu His Ala Pro Leu Pro Pro Thr Ser Pro
     210                 215                 220                
 Gln Pro Pro Glu Glu Pro Pro Leu Pro Asp Glu Asp Glu Glu Leu Ser
 225                 230                 235                 240
 Ser Glu Glu Ser Glu Tyr Glu Ser Thr Asp Asp Glu Asp Arg Gln Arg
                 245                 250                 255    
 Met Asn Lys Leu Met Glu Leu Ala Asn Leu Gln Pro Lys Arg Pro Lys
             260                 265                 270        
 Thr Ile Lys Gln Arg His Val Arg Lys Lys Arg Lys Ile Lys Asp Met
         275                 280                 285            
 Leu Asn Thr Pro Leu Cys Pro Ser His Ser Ser Leu His Pro Val Leu
     290                 295                 300                
 Leu Pro Ser Asp Val Phe Asp Gln Pro Gln Pro Val Gly Asn Lys Arg
 305                 310                 315                 320
 Ile Glu Phe His Ile Ser Thr Asp Met Pro Ala Ala Phe Lys Lys Asp
                 325                 330                 335    
 Leu Glu Lys Glu Gln Asn Cys Glu Glu Lys Asn His Asp Leu Pro Ala
             340                 345                 350        
 Thr Glu Val Asp Ala Ser Asn Ile Gly Phe Gly Lys Ile Phe Pro Lys
         355                 360                 365            
 Pro Asn Leu Asp Ile Thr Glu Glu Ile Lys Glu Asp Ser Asp Glu Met
     370                 375                 380                
 Pro Ser Glu Cys Ile Ser Arg Arg Glu Leu Glu Lys Gly Arg Ile Ser
 385                 390                 395                 400
 Arg Glu Gly Asn Val Thr Lys
                 405        



      <210> 250
      <211> 260
      <212> PRT
      <213> Homo sapiens


      <400> 250
 Met Ala Lys Glu Trp Gly Tyr Ala Ser His Asn Gly Pro Asp His Trp
   1               5                  10                  15    
 His Glu Leu Phe Pro Asn Ala Lys Gly Glu Asn Gln Ser Pro Val Glu
              20                  25                  30        
 Leu His Thr Lys Asp Ile Arg His Asp Pro Ser Leu Gln Pro Trp Ser
          35                  40                  45            
 Val Ser Tyr Asp Gly Gly Ser Ala Lys Thr Ile Leu Asn Asn Gly Lys
      50                  55                  60                
 Thr Cys Arg Val Val Phe Asp Asp Thr Tyr Asp Arg Ser Met Leu Arg
  65                  70                  75                  80
 Gly Gly Pro Leu Pro Gly Pro Tyr Arg Leu Arg Gln Phe His Leu His
                  85                  90                  95    
 Trp Gly Ser Ser Asp Asp His Gly Ser Glu His Thr Val Asp Gly Val
             100                 105                 110        
 Lys Tyr Ala Ala Glu Leu His Leu Val His Trp Asn Pro Lys Tyr Asn
         115                 120                 125            
 Thr Phe Lys Glu Ala Leu Lys Gln Arg Asp Gly Ile Ala Val Ile Gly
     130                 135                 140                
 Ile Phe Leu Lys Ile Gly His Glu Asn Gly Glu Phe Gln Ile Phe Leu
 145                 150                 155                 160
 Asp Ala Leu Asp Lys Ile Lys Thr Lys Gly Lys Glu Ala Pro Phe Thr
                 165                 170                 175    
 Lys Phe Asp Pro Ser Cys Leu Phe Pro Ala Cys Arg Asp Tyr Trp Thr
             180                 185                 190        
 Tyr Gln Gly Ser Phe Thr Thr Pro Pro Cys Glu Glu Cys Ile Val Trp
         195                 200                 205            
 Leu Leu Leu Lys Glu Pro Met Thr Val Ser Ser Asp Gln Met Ala Lys
     210                 215                 220                
 Leu Arg Ser Leu Leu Ser Ser Ala Glu Asn Glu Pro Pro Val Pro Leu
 225                 230                 235                 240
 Val Ser Asn Trp Arg Pro Pro Gln Pro Ile Asn Asn Arg Val Val Arg
                 245                 250                 255    
 Ala Ser Phe Lys
             260



      <210> 251
      <211> 267
      <212> PRT
      <213> Homo sapiens


      <400> 251
 Met Ser Gly Cys Phe Pro Val Ser Gly Leu Arg Cys Leu Ser Arg Asp
   1               5                  10                  15    
 Gly Arg Met Ala Ala Gln Gly Ala Pro Arg Phe Leu Leu Thr Phe Asp
              20                  25                  30        
 Phe Asp Glu Thr Ile Val Asp Glu Asn Ser Asp Asp Ser Ile Val Arg
          35                  40                  45            
 Ala Ala Pro Gly Gln Arg Leu Pro Glu Ser Leu Arg Ala Thr Tyr Arg
      50                  55                  60                
 Glu Gly Phe Tyr Asn Glu Tyr Met Gln Arg Val Phe Lys Tyr Leu Gly
  65                  70                  75                  80
 Glu Gln Gly Val Arg Pro Arg Asp Leu Ser Ala Ile Tyr Glu Ala Ile
                  85                  90                  95    
 Pro Leu Ser Pro Gly Met Ser Asp Leu Leu Gln Phe Val Ala Lys Gln
             100                 105                 110        
 Gly Ala Cys Phe Glu Val Ile Leu Ile Ser Asp Ala Asn Thr Phe Gly
         115                 120                 125            
 Val Glu Ser Ser Leu Arg Ala Ala Gly His His Ser Leu Phe Arg Arg
     130                 135                 140                
 Ile Leu Ser Asn Pro Ser Gly Pro Asp Ala Arg Gly Leu Leu Ala Leu
 145                 150                 155                 160
 Arg Pro Phe His Thr His Ser Cys Ala Arg Cys Pro Ala Asn Met Cys
                 165                 170                 175    
 Lys His Lys Val Leu Ser Asp Tyr Leu Arg Glu Arg Ala His Asp Gly
             180                 185                 190        
 Val His Phe Glu Arg Leu Phe Tyr Val Gly Asp Gly Ala Asn Asp Phe
         195                 200                 205            
 Cys Pro Met Gly Leu Leu Ala Gly Gly Asp Val Ala Phe Pro Arg Arg
     210                 215                 220                
 Gly Tyr Pro Met His Arg Leu Ile Gln Glu Ala Gln Lys Ala Glu Pro
 225                 230                 235                 240
 Ser Ser Phe Arg Ala Ser Val Val Pro Trp Glu Thr Ala Ala Asp Val
                 245                 250                 255    
 Arg Leu His Leu Gln Gln Val Leu Lys Ser Cys
             260                 265        



      <210> 252
      <211> 384
      <212> PRT
      <213> Homo sapiens


      <400> 252
 Met Glu Gly Leu Gly Arg Ser Cys Leu Trp Leu Arg Arg Glu Leu Ser
   1               5                  10                  15    
 Pro Pro Arg Pro Arg Leu Leu Leu Leu Asp Cys Arg Ser Arg Glu Leu
              20                  25                  30        
 Tyr Glu Ser Ala Arg Ile Gly Gly Ala Leu Ser Val Ala Leu Pro Ala
          35                  40                  45            
 Leu Leu Leu Arg Arg Leu Arg Arg Gly Ser Leu Ser Val Arg Ala Leu
      50                  55                  60                
 Leu Pro Gly Pro Pro Leu Gln Pro Pro Pro Pro Ala Pro Val Leu Leu
  65                  70                  75                  80
 Tyr Asp Gln Gly Gly Gly Arg Arg Arg Arg Gly Glu Ala Glu Ala Glu
                  85                  90                  95    
 Ala Glu Glu Trp Glu Ala Glu Ser Val Leu Gly Thr Leu Leu Gln Lys
             100                 105                 110        
 Leu Arg Glu Glu Gly Tyr Leu Ala Tyr Tyr Leu Gln Gly Gly Phe Ser
         115                 120                 125            
 Arg Phe Gln Ala Glu Cys Pro His Leu Cys Glu Thr Ser Leu Ala Gly
     130                 135                 140                
 Arg Ala Gly Ser Ser Met Ala Pro Val Pro Gly Pro Val Pro Val Val
 145                 150                 155                 160
 Gly Leu Gly Ser Leu Cys Leu Gly Ser Asp Cys Ser Asp Ala Glu Ser
                 165                 170                 175    
 Glu Ala Asp Arg Asp Ser Met Ser Cys Gly Leu Asp Ser Glu Gly Ala
             180                 185                 190        
 Thr Pro Pro Pro Val Gly Leu Arg Ala Ser Phe Pro Val Gln Ile Leu
         195                 200                 205            
 Pro Asn Leu Tyr Leu Gly Ser Ala Arg Asp Ser Ala Asn Leu Glu Ser
     210                 215                 220                
 Leu Ala Lys Leu Gly Ile Arg Tyr Ile Leu Asn Val Thr Pro Asn Leu
 225                 230                 235                 240
 Pro Asn Phe Phe Glu Lys Asn Gly Asp Phe His Tyr Lys Gln Ile Pro
                 245                 250                 255    
 Ile Ser Asp His Trp Ser Gln Asn Leu Ser Arg Phe Phe Pro Glu Ala
             260                 265                 270        
 Ile Glu Phe Ile Asp Glu Ala Leu Ser Gln Asn Cys Gly Val Leu Val
         275                 280                 285            
 His Cys Leu Ala Gly Val Ser Arg Ser Val Thr Val Thr Val Ala Tyr
     290                 295                 300                
 Leu Met Gln Lys Leu His Leu Ser Leu Asn Asp Ala Tyr Asp Leu Val
 305                 310                 315                 320
 Lys Arg Lys Lys Ser Asn Ile Ser Pro Asn Phe Asn Phe Met Gly Gln
                 325                 330                 335    
 Leu Leu Asp Phe Glu Arg Ser Leu Arg Leu Glu Glu Arg His Ser Gln
             340                 345                 350        
 Glu Gln Gly Ser Gly Gly Gln Ala Ser Ala Ala Ser Asn Pro Pro Ser
         355                 360                 365            
 Phe Phe Thr Thr Pro Thr Ser Asp Gly Ala Phe Glu Leu Ala Pro Thr
     370                 375                 380                





      <210> 253
      <211> 206
      <212> PRT
      <213> Homo sapiens


      <400> 253
 Met Arg Arg Thr Gly Ala Pro Ala Gln Ala Asp Ser Arg Gly Arg Gly
   1               5                  10                  15    
 Arg Ala Arg Gly Gly Cys Pro Gly Gly Glu Ala Thr Leu Ser Gln Pro
              20                  25                  30        
 Pro Pro Arg Gly Gly Thr Arg Gly Gln Glu Pro Gln Met Lys Glu Thr
          35                  40                  45            
 Ile Met Asn Gln Glu Lys Leu Ala Lys Leu Gln Ala Gln Val Arg Ile
      50                  55                  60                
 Gly Gly Lys Gly Thr Ala Arg Arg Lys Lys Lys Val Val His Arg Thr
  65                  70                  75                  80
 Ala Thr Ala Asp Asp Lys Lys Leu Gln Phe Ser Leu Lys Lys Leu Gly
                  85                  90                  95    
 Val Asn Asn Ile Ser Gly Ile Glu Glu Val Asn Met Phe Thr Asn Gln
             100                 105                 110        
 Gly Thr Val Ile His Phe Asn Asn Pro Lys Val Gln Ala Ser Leu Ala
         115                 120                 125            
 Ala Asn Thr Phe Thr Ile Thr Gly His Ala Glu Thr Lys Gln Leu Thr
     130                 135                 140                
 Glu Met Leu Pro Ser Ile Leu Asn Gln Leu Gly Ala Asp Ser Leu Thr
 145                 150                 155                 160
 Ser Leu Arg Arg Leu Ala Glu Ala Leu Pro Lys Gln Ser Val Asp Gly
                 165                 170                 175    
 Lys Ala Pro Leu Ala Thr Gly Glu Asp Asp Asp Asp Glu Val Pro Asp
             180                 185                 190        
 Leu Val Glu Asn Phe Asp Glu Ala Ser Lys Asn Glu Ala Asn
         195                 200                 205    



      <210> 254
      <211> 102
      <212> PRT
      <213> Homo sapiens


      <400> 254
 Met Leu Tyr Leu Lys Lys Gly Ser Ala Ser Ala Leu Pro Arg Phe Leu
   1               5                  10                  15    
 Val Thr Asn Leu Gln Thr Asn Leu Ser Trp His Arg Pro Leu Pro Tyr
              20                  25                  30        
 Ile Gly Ser Leu Ser Pro Gly Pro Pro Leu Pro Pro Pro Cys Cys His
          35                  40                  45            
 His Cys Pro Gly Pro Arg His Pro Gly Leu Pro Glu Ser Ala Arg Ala
      50                  55                  60                
 Ser Lys Lys Ala Pro Leu Ser Leu Glu Thr Gly Gly His Thr Ser Leu
  65                  70                  75                  80
 Ser Glu Ser Pro Ala Gly Leu Lys Gly Gln Trp Ile Val Ile Val Glu
                  85                  90                  95    
 Ile Val Trp Leu Arg Leu
             100        



      <210> 255
      <211> 182
      <212> PRT
      <213> Homo sapiens


      <400> 255
 Met Glu Leu Gly Glu Leu Leu Tyr Asn Lys Ser Glu Tyr Ile Glu Thr
   1               5                  10                  15    
 Ala Ser Gly Asn Lys Val Ser Arg Gln Ser Val Leu Cys Gly Ser Gln
              20                  25                  30        
 Asn Ile Val Leu Asn Gly Lys Thr Ile Val Met Asn Asp Cys Ile Ile
          35                  40                  45            
 Arg Gly Asp Leu Ala Asn Val Arg Val Gly Arg His Cys Val Val Lys
      50                  55                  60                
 Ser Arg Ser Val Ile Arg Pro Pro Phe Lys Lys Phe Ser Lys Gly Val
  65                  70                  75                  80
 Ala Phe Phe Pro Leu His Ile Gly Asp His Val Phe Ile Glu Glu Asp
                  85                  90                  95    
 Cys Val Val Asn Ala Ala Gln Ile Gly Ser Tyr Val His Val Gly Lys
             100                 105                 110        
 Asn Cys Val Ile Gly Arg Arg Cys Val Leu Lys Asp Cys Cys Lys Ile
         115                 120                 125            
 Leu Asp Asn Thr Val Leu Pro Pro Glu Thr Val Val Pro Pro Phe Thr
     130                 135                 140                
 Val Phe Ser Gly Cys Pro Gly Leu Phe Ser Gly Glu Leu Pro Glu Cys
 145                 150                 155                 160
 Thr Gln Glu Leu Met Ile Asp Val Thr Lys Ser Tyr Tyr Gln Lys Phe
                 165                 170                 175    
 Leu Pro Leu Thr Gln Val
             180        



      <210> 256
      <211> 1347
      <212> PRT
      <213> Homo sapiens


      <400> 256
 Met Leu Gly Leu Gly Phe Arg Gly Ser Ala Val Leu Gly Val Cys Trp
   1               5                  10                  15    
 Gln Leu Arg Ser Pro Pro Ser Arg Ala Ala Arg Met Met Asn Arg Thr
              20                  25                  30        
 Thr Pro Asp Gln Glu Leu Ala Pro Ala Ser Glu Pro Val Trp Glu Arg
          35                  40                  45            
 Pro Trp Ser Met Glu Glu Ile Arg Arg Ser Ser Gln Ser Trp Ser Leu
      50                  55                  60                
 Ala Ala Asp Ala Gly Leu Leu Gln Phe Leu Gln Glu Phe Ser Gln Gln
  65                  70                  75                  80
 Thr Ile Ser Arg Thr His Glu Ile Lys Lys Gln Val Asp Gly Leu Ile
                  85                  90                  95    
 Arg Glu Thr Lys Ala Thr Asp Cys Arg Leu His Asn Val Phe Asn Asp
             100                 105                 110        
 Phe Leu Met Leu Ser Asn Thr Gln Phe Ile Glu Asn Arg Val Tyr Asp
         115                 120                 125            
 Glu Glu Val Glu Glu Pro Val Leu Lys Ala Glu Ala Glu Lys Thr Glu
     130                 135                 140                
 Gln Glu Lys Thr Arg Glu Gln Lys Glu Val Asp Leu Ile Pro Lys Val
 145                 150                 155                 160
 Gln Glu Ala Val Asn Tyr Gly Leu Gln Val Leu Asp Ser Ala Phe Glu
                 165                 170                 175    
 Gln Leu Asp Ile Lys Ala Gly Asn Ser Asp Ser Glu Glu Asp Asp Ala
             180                 185                 190        
 Asn Gly Arg Val Glu Leu Ile Leu Glu Pro Lys Asp Leu Tyr Ile Asp
         195                 200                 205            
 Arg Pro Leu Pro Tyr Leu Ile Gly Ser Lys Leu Phe Met Glu Gln Glu
     210                 215                 220                
 Asp Val Gly Leu Gly Glu Leu Ser Ser Glu Glu Gly Ser Val Gly Ser
 225                 230                 235                 240
 Asp Arg Gly Ser Ile Val Asp Thr Glu Glu Glu Lys Glu Glu Glu Glu
                 245                 250                 255    
 Ser Asp Glu Asp Phe Ala His His Ser Asp Asn Glu Gln Asn Gln His
             260                 265                 270        
 Thr Thr Gln Met Ser Asp Glu Glu Glu Asp Asp Asp Gly Cys Asp Leu
         275                 280                 285            
 Phe Ala Asp Ser Glu Lys Glu Glu Glu Asp Ile Glu Asp Ile Glu Glu
     290                 295                 300                
 Asn Thr Arg Pro Lys Arg Ser Arg Pro Thr Ser Phe Ala Asp Glu Leu
 305                 310                 315                 320
 Ala Ala Arg Ile Lys Gly Asp Ala Met Gly Arg Val Asp Glu Glu Pro
                 325                 330                 335    
 Thr Thr Leu Pro Ser Gly Glu Ala Lys Pro Arg Lys Thr Leu Lys Glu
             340                 345                 350        
 Lys Lys Glu Arg Arg Thr Pro Ser Asp Asp Glu Glu Asp Asn Leu Phe
         355                 360                 365            
 Ala Pro Pro Lys Leu Thr Asp Glu Asp Phe Ser Pro Phe Gly Ser Gly
     370                 375                 380                
 Gly Gly Leu Phe Ser Gly Gly Lys Gly Leu Phe Asp Asp Glu Asp Glu
 385                 390                 395                 400
 Glu Ser Asp Leu Phe Thr Glu Ala Pro Gln Asp Arg Gln Ala Gly Ala
                 405                 410                 415    
 Ser Val Lys Glu Glu Ser Ser Ser Ser Lys Pro Gly Lys Lys Ile Pro
             420                 425                 430        
 Ala Gly Ala Val Ser Val Phe Leu Gly Asp Thr Asp Val Phe Gly Ala
         435                 440                 445            
 Ala Ser Val Pro Ser Met Lys Glu Pro Gln Lys Pro Glu Gln Pro Thr
     450                 455                 460                
 Pro Arg Lys Ser Pro Tyr Gly Pro Pro Pro Thr Gly Leu Phe Asp Asp
 465                 470                 475                 480
 Asp Asp Gly Asp Asp Asp Asp Asp Phe Phe Ser Ala Pro His Ser Lys
                 485                 490                 495    
 Pro Ser Lys Thr Gly Lys Val Gln Ser Thr Ala Asp Ile Phe Gly Asp
             500                 505                 510        
 Glu Glu Gly Asp Leu Phe Lys Glu Lys Ala Val Ala Ser Pro Glu Ala
         515                 520                 525            
 Thr Val Ser Gln Thr Asp Glu Asn Lys Ala Arg Ala Glu Lys Lys Val
     530                 535                 540                
 Thr Leu Ser Ser Ser Lys Asn Leu Lys Pro Ser Ser Glu Thr Lys Thr
 545                 550                 555                 560
 Gln Lys Gly Leu Phe Ser Asp Glu Glu Asp Ser Glu Asp Leu Phe Ser
                 565                 570                 575    
 Ser Gln Ser Ala Ser Asn Leu Lys Gly Ala Ser Leu Leu Pro Gly Lys
             580                 585                 590        
 Leu Pro Thr Ser Val Ser Leu Phe Asp Asp Glu Asp Glu Glu Asp Asn
         595                 600                 605            
 Leu Phe Gly Gly Thr Ala Ala Lys Lys Gln Thr Leu Ser Leu Gln Ala
     610                 615                 620                
 Gln Arg Glu Glu Lys Ala Lys Ala Ser Glu Leu Ser Lys Lys Lys Ala
 625                 630                 635                 640
 Ser Ala Leu Leu Phe Ser Ser Asp Glu Glu Asp Gln Trp Asn Ile Pro
                 645                 650                 655    
 Ala Ser Gln Thr His Leu Ala Ser Asp Ser Arg Ser Lys Gly Glu Pro
             660                 665                 670        
 Arg Asp Ser Gly Thr Leu Gln Ser Gln Glu Ala Lys Ala Val Lys Lys
         675                 680                 685            
 Thr Ser Leu Phe Glu Glu Asp Glu Glu Asp Asp Leu Phe Ala Ile Ala
     690                 695                 700                
 Lys Asp Ser Gln Lys Lys Thr Gln Arg Val Ser Leu Leu Phe Glu Asp
 705                 710                 715                 720
 Asp Val Asp Ser Gly Gly Ser Leu Phe Gly Ser Pro Pro Thr Ser Val
                 725                 730                 735    
 Pro Pro Ala Thr Lys Lys Lys Glu Thr Val Ser Glu Ala Pro Pro Leu
             740                 745                 750        
 Leu Phe Ser Asp Glu Glu Glu Lys Glu Ala Gln Leu Gly Val Lys Ser
         755                 760                 765            
 Val Asp Lys Lys Val Glu Ser Ala Lys Glu Ser Leu Lys Phe Gly Arg
     770                 775                 780                
 Thr Asp Val Ala Glu Ser Glu Lys Glu Gly Leu Leu Thr Arg Ser Ala
 785                 790                 795                 800
 Gln Glu Thr Val Lys His Ser Asp Leu Phe Ser Ser Ser Ser Pro Trp
                 805                 810                 815    
 Asp Lys Gly Thr Lys Pro Arg Thr Lys Thr Val Leu Ser Leu Phe Asp
             820                 825                 830        
 Glu Glu Glu Asp Lys Met Glu Asp Gln Asn Ile Ile Gln Ala Pro Gln
         835                 840                 845            
 Lys Glu Val Gly Lys Gly Cys Asp Pro Asp Ala His Pro Lys Ser Thr
     850                 855                 860                
 Gly Val Phe Gln Asp Glu Glu Leu Leu Phe Ser His Lys Leu Gln Lys
 865                 870                 875                 880
 Asp Asn Asp Pro Asp Val Asp Leu Phe Ala Gly Thr Lys Lys Thr Lys
                 885                 890                 895    
 Leu Leu Glu Pro Ser Val Gly Ser Leu Phe Gly Asp Asp Glu Asp Asp
             900                 905                 910        
 Asp Leu Phe Ser Ser Ala Lys Ser Gln Pro Leu Val Gln Glu Lys Lys
         915                 920                 925            
 Arg Val Val Lys Lys Asp His Ser Val Asn Ser Phe Lys Asn Gln Lys
     930                 935                 940                
 His Pro Glu Ser Ile Gln Gly Ser Lys Glu Lys Gly Ile Trp Lys Pro
 945                 950                 955                 960
 Glu Thr Pro Gln Ala Asn Leu Ala Ile Asn Pro Ala Ala Leu Leu Pro
                 965                 970                 975    
 Thr Ala Ala Ser Gln Ile Ser Glu Val Lys Pro Val Leu Pro Glu Leu
             980                 985                 990        
 Ala Phe Pro Ser Ser Glu His Arg Arg Ser His Gly Leu Glu Ser Val
         995                1000                1005            
 Pro Val Leu Pro Gly Ser Gly Glu Ala Gly Val Ser Phe Asp Leu Pro
    1010                1015                1020                
 Ala Gln Ala Asp Thr Leu His Ser Ala Asn Lys Ser Arg Val Lys Met
1025                1030                1035                1040
 Arg Gly Lys Arg Arg Pro Gln Thr Arg Ala Ala Arg Arg Leu Ala Ala
                1045                1050                1055    
 Gln Glu Ser Ser Glu Ala Glu Asp Met Ser Ile Pro Arg Gly Pro Ile
            1060                1065                1070        
 Ala Gln Trp Ala Asp Gly Ala Ile Ser Pro Asn Gly His Arg Pro Gln
        1075                1080                1085            
 Leu Arg Ala Ala Ser Gly Glu Asp Ser Thr Glu Glu Ala Leu Ala Ala
    1090                1095                1100                
 Ala Ala Ala Pro Trp Glu Gly Gly Pro Val Pro Gly Val Asp Thr Ser
1105                1110                1115                1120
 Pro Phe Ala Lys Ser Leu Gly His Ser Arg Gly Glu Ala Asp Leu Phe
                1125                1130                1135    
 Asp Ser Gly Asp Ile Phe Ser Thr Gly Thr Gly Ser Gln Ser Val Glu
            1140                1145                1150        
 Arg Thr Lys Pro Lys Ala Lys Ile Ala Glu Asn Pro Ala Asn Pro Pro
        1155                1160                1165            
 Val Gly Gly Lys Ala Lys Ser Pro Met Phe Pro Ala Leu Gly Glu Ala
    1170                1175                1180                
 Ser Ser Asp Asp Asp Leu Phe Gln Ser Ala Lys Pro Lys Pro Ala Lys
1185                1190                1195                1200
 Lys Thr Asn Pro Phe Pro Leu Leu Glu Asp Glu Asp Asp Leu Phe Thr
                1205                1210                1215    
 Asp Gln Lys Val Lys Lys Asn Glu Thr Lys Ser Ser Ser Gln Gln Asp
            1220                1225                1230        
 Val Ile Leu Thr Thr Gln Asp Ile Phe Glu Asp Asp Ile Phe Ala Thr
        1235                1240                1245            
 Glu Ala Ile Lys Pro Ser Gln Lys Thr Arg Glu Lys Glu Lys Thr Leu
    1250                1255                1260                
 Glu Ser Asn Leu Phe Asp Asp Asn Ile Asp Ile Phe Ala Asp Leu Thr
1265                1270                1275                1280
 Val Lys Pro Lys Glu Lys Ser Lys Lys Lys Val Glu Ala Lys Ser Ile
                1285                1290                1295    
 Phe Asp Asp Asp Met Asp Asp Ile Phe Ser Ser Gly Ile Gln Ala Lys
            1300                1305                1310        
 Thr Thr Lys Pro Lys Ser Arg Ser Ala Gln Ala Ala Pro Glu Pro Arg
        1315                1320                1325            
 Phe Glu His Lys Val Ser Asn Ile Phe Asp Asp Pro Leu Asn Ala Phe
    1330                1335                1340                
 Gly Gly Gln
1345        



      <210> 257
      <211> 1368
      <212> PRT
      <213> Homo sapiens


      <400> 257
 Met Leu Gly Leu Gly Phe Arg Gly Ser Ala Val Leu Gly Val Cys Trp
   1               5                  10                  15    
 Gln Leu Arg Ser Pro Pro Ser Arg Ala Ala Arg Met Met Asn Arg Thr
              20                  25                  30        
 Thr Pro Asp Gln Glu Leu Ala Pro Ala Ser Glu Pro Val Trp Glu Arg
          35                  40                  45            
 Pro Trp Ser Met Glu Glu Ile Arg Arg Ser Ser Gln Ser Trp Ser Leu
      50                  55                  60                
 Ala Ala Asp Ala Gly Leu Leu Gln Phe Leu Gln Glu Phe Ser Gln Gln
  65                  70                  75                  80
 Thr Ile Ser Arg Thr His Glu Ile Lys Lys Gln Val Asp Gly Leu Ile
                  85                  90                  95    
 Arg Glu Thr Lys Ala Thr Asp Cys Arg Leu His Asn Val Phe Asn Asp
             100                 105                 110        
 Phe Leu Met Leu Ser Asn Thr Gln Phe Ile Glu Asn Arg Val Tyr Asp
         115                 120                 125            
 Glu Glu Val Glu Glu Pro Val Leu Lys Ala Glu Ala Glu Lys Thr Glu
     130                 135                 140                
 Gln Glu Lys Thr Arg Glu Gln Lys Glu Val Asp Leu Ile Pro Lys Val
 145                 150                 155                 160
 Gln Glu Ala Val Asn Tyr Gly Leu Gln Val Leu Asp Ser Ala Phe Glu
                 165                 170                 175    
 Gln Leu Asp Ile Lys Ala Gly Asn Ser Asp Ser Glu Glu Asp Asp Ala
             180                 185                 190        
 Asn Gly Arg Val Glu Leu Ile Leu Glu Pro Lys Asp Leu Tyr Ile Asp
         195                 200                 205            
 Arg Pro Leu Pro Tyr Leu Ile Gly Ser Lys Leu Phe Met Glu Gln Glu
     210                 215                 220                
 Asp Val Gly Leu Gly Glu Leu Ser Ser Glu Glu Gly Ser Val Gly Ser
 225                 230                 235                 240
 Asp Arg Gly Ser Ile Val Asp Thr Glu Glu Glu Lys Glu Glu Glu Glu
                 245                 250                 255    
 Ser Asp Glu Asp Phe Ala His His Ser Asp Asn Glu Gln Asn Gln His
             260                 265                 270        
 Thr Thr Gln Met Ser Asp Glu Glu Glu Asp Asp Asp Gly Cys Asp Leu
         275                 280                 285            
 Phe Ala Asp Ser Glu Lys Glu Glu Glu Asp Ile Glu Asp Ile Glu Glu
     290                 295                 300                
 Asn Thr Arg Pro Lys Arg Ser Arg Pro Thr Ser Phe Ala Asp Glu Leu
 305                 310                 315                 320
 Ala Ala Arg Ile Lys Gly Asp Ala Met Gly Arg Val Asp Glu Glu Pro
                 325                 330                 335    
 Thr Thr Leu Pro Ser Gly Glu Ala Lys Pro Arg Lys Thr Leu Lys Glu
             340                 345                 350        
 Lys Lys Glu Arg Arg Thr Pro Ser Asp Asp Glu Glu Asp Asn Leu Phe
         355                 360                 365            
 Ala Pro Pro Lys Leu Thr Asp Glu Asp Phe Ser Pro Phe Gly Ser Gly
     370                 375                 380                
 Gly Gly Leu Phe Ser Gly Gly Lys Gly Leu Phe Asp Asp Glu Asp Glu
 385                 390                 395                 400
 Glu Ser Asp Leu Phe Thr Glu Ala Pro Gln Asp Arg Gln Ala Gly Ala
                 405                 410                 415    
 Ser Val Lys Glu Glu Ser Ser Ser Ser Lys Pro Gly Lys Lys Ile Pro
             420                 425                 430        
 Ala Gly Ala Val Ser Val Phe Leu Gly Asp Thr Asp Val Phe Gly Ala
         435                 440                 445            
 Ala Ser Val Pro Ser Met Lys Glu Pro Gln Lys Pro Glu Gln Pro Thr
     450                 455                 460                
 Pro Arg Lys Ser Pro Tyr Gly Pro Pro Pro Thr Gly Leu Phe Asp Asp
 465                 470                 475                 480
 Asp Asp Gly Asp Asp Asp Asp Asp Phe Phe Ser Ala Pro His Ser Lys
                 485                 490                 495    
 Pro Ser Lys Thr Gly Lys Val Gln Ser Thr Ala Asp Ile Phe Gly Asp
             500                 505                 510        
 Glu Glu Gly Asp Leu Phe Lys Glu Lys Ala Val Ala Ser Pro Glu Ala
         515                 520                 525            
 Thr Val Ser Gln Thr Asp Glu Asn Lys Ala Arg Ala Glu Lys Lys Val
     530                 535                 540                
 Thr Leu Ser Ser Ser Lys Asn Leu Lys Pro Ser Ser Glu Thr Lys Thr
 545                 550                 555                 560
 Gln Lys Gly Leu Phe Ser Asp Glu Glu Asp Ser Glu Asp Leu Phe Ser
                 565                 570                 575    
 Ser Gln Ser Ala Ser Asn Leu Lys Gly Ala Ser Leu Leu Pro Gly Lys
             580                 585                 590        
 Leu Pro Thr Ser Val Ser Leu Phe Asp Asp Glu Asp Glu Glu Asp Asn
         595                 600                 605            
 Leu Phe Gly Gly Thr Ala Ala Lys Lys Gln Thr Leu Ser Leu Gln Ala
     610                 615                 620                
 Gln Arg Glu Glu Lys Ala Lys Ala Ser Glu Leu Ser Lys Lys Lys Ala
 625                 630                 635                 640
 Ser Ala Leu Leu Phe Ser Ser Asp Glu Glu Asp Gln Trp Asn Ile Pro
                 645                 650                 655    
 Ala Ser Gln Thr His Leu Ala Ser Asp Ser Arg Ser Lys Gly Glu Pro
             660                 665                 670        
 Arg Asp Ser Gly Thr Leu Gln Ser Gln Glu Ala Lys Ala Val Lys Lys
         675                 680                 685            
 Thr Ser Leu Phe Glu Glu Asp Glu Glu Asp Asp Leu Phe Ala Ile Ala
     690                 695                 700                
 Lys Asp Ser Gln Lys Lys Thr Gln Arg Val Ser Leu Leu Phe Glu Asp
 705                 710                 715                 720
 Asp Val Asp Ser Gly Gly Ser Leu Phe Gly Ser Pro Pro Thr Ser Val
                 725                 730                 735    
 Pro Pro Ala Thr Lys Lys Lys Glu Thr Val Ser Glu Ala Pro Pro Leu
             740                 745                 750        
 Leu Phe Ser Asp Glu Glu Glu Lys Glu Ala Gln Leu Gly Val Lys Ser
         755                 760                 765            
 Val Asp Lys Lys Val Glu Ser Ala Lys Glu Ser Leu Lys Phe Gly Arg
     770                 775                 780                
 Thr Asp Val Ala Glu Ser Glu Lys Glu Gly Leu Leu Thr Arg Ser Ala
 785                 790                 795                 800
 Gln Glu Thr Val Lys His Ser Asp Leu Phe Ser Ser Ser Ser Pro Trp
                 805                 810                 815    
 Asp Lys Gly Thr Lys Pro Arg Thr Lys Thr Val Leu Ser Leu Phe Asp
             820                 825                 830        
 Glu Glu Glu Asp Lys Met Glu Asp Gln Asn Ile Ile Gln Ala Pro Gln
         835                 840                 845            
 Lys Glu Val Gly Lys Gly Cys Asp Pro Asp Ala His Pro Lys Ser Thr
     850                 855                 860                
 Gly Val Phe Gln Asp Glu Glu Leu Leu Phe Ser His Lys Leu Gln Lys
 865                 870                 875                 880
 Asp Asn Asp Pro Asp Val Asp Leu Phe Ala Gly Thr Lys Lys Thr Lys
                 885                 890                 895    
 Leu Leu Glu Pro Ser Val Gly Ser Leu Phe Gly Asp Asp Glu Asp Asp
             900                 905                 910        
 Asp Leu Phe Ser Ser Ala Lys Ser Gln Pro Leu Val Gln Glu Lys Lys
         915                 920                 925            
 Arg Val Val Lys Lys Asp His Ser Val Asn Ser Phe Lys Asn Gln Lys
     930                 935                 940                
 His Pro Glu Ser Ile Gln Gly Ser Lys Glu Lys Gly Ile Trp Lys Pro
 945                 950                 955                 960
 Glu Thr Pro Gln Asp Ser Ser Gly Leu Ala Pro Phe Lys Thr Lys Glu
                 965                 970                 975    
 Pro Ser Thr Arg Ile Gly Lys Ile Gln Ala Asn Leu Ala Ile Asn Pro
             980                 985                 990        
 Ala Ala Leu Leu Pro Thr Ala Ala Ser Gln Ile Ser Glu Val Lys Pro
         995                1000                1005            
 Val Leu Pro Glu Leu Ala Phe Pro Ser Ser Glu His Arg Arg Ser His
    1010                1015                1020                
 Gly Leu Glu Ser Val Pro Val Leu Pro Gly Ser Gly Glu Ala Gly Val
1025                1030                1035                1040
 Ser Phe Asp Leu Pro Ala Gln Ala Asp Thr Leu His Ser Ala Asn Lys
                1045                1050                1055    
 Ser Arg Val Lys Met Arg Gly Lys Arg Arg Pro Gln Thr Arg Ala Ala
            1060                1065                1070        
 Arg Arg Leu Ala Ala Gln Glu Ser Ser Glu Ala Glu Asp Met Ser Ile
        1075                1080                1085            
 Pro Arg Gly Pro Ile Ala Gln Trp Ala Asp Gly Ala Ile Ser Pro Asn
    1090                1095                1100                
 Gly His Arg Pro Gln Leu Arg Ala Ala Ser Gly Glu Asp Ser Thr Glu
1105                1110                1115                1120
 Glu Ala Leu Ala Ala Ala Ala Ala Pro Trp Glu Gly Gly Pro Val Pro
                1125                1130                1135    
 Gly Val Asp Thr Ser Pro Phe Ala Lys Ser Leu Gly His Ser Arg Gly
            1140                1145                1150        
 Glu Ala Asp Leu Phe Asp Ser Gly Asp Ile Phe Ser Thr Gly Thr Gly
        1155                1160                1165            
 Ser Gln Ser Val Glu Arg Thr Lys Pro Lys Ala Lys Ile Ala Glu Asn
    1170                1175                1180                
 Pro Ala Asn Pro Pro Val Gly Gly Lys Ala Lys Ser Pro Met Phe Pro
1185                1190                1195                1200
 Ala Leu Gly Glu Ala Ser Ser Asp Asp Asp Leu Phe Gln Ser Ala Lys
                1205                1210                1215    
 Pro Lys Pro Ala Lys Lys Thr Asn Pro Phe Pro Leu Leu Glu Asp Glu
            1220                1225                1230        
 Asp Asp Leu Phe Thr Asp Gln Lys Val Lys Lys Asn Glu Thr Lys Ser
        1235                1240                1245            
 Ser Ser Gln Gln Asp Val Ile Leu Thr Thr Gln Asp Ile Phe Glu Asp
    1250                1255                1260                
 Asp Ile Phe Ala Thr Glu Ala Ile Lys Pro Ser Gln Lys Thr Arg Glu
1265                1270                1275                1280
 Lys Glu Lys Thr Leu Glu Ser Asn Leu Phe Asp Asp Asn Ile Asp Ile
                1285                1290                1295    
 Phe Ala Asp Leu Thr Val Lys Pro Lys Glu Lys Ser Lys Lys Lys Val
            1300                1305                1310        
 Glu Ala Lys Ser Ile Phe Asp Asp Asp Met Asp Asp Ile Phe Ser Ser
        1315                1320                1325            
 Gly Ile Gln Ala Lys Thr Thr Lys Pro Lys Ser Arg Ser Ala Gln Ala
    1330                1335                1340                
 Ala Pro Glu Pro Arg Phe Glu His Lys Val Ser Asn Ile Phe Asp Asp
1345                1350                1355                1360
 Pro Leu Asn Ala Phe Gly Gly Gln
                1365            



      <210> 258
      <211> 129
      <212> PRT
      <213> Homo sapiens


      <400> 258
 Met Ser Ile Ser Arg Ala Val Leu Gly Glu Lys Glu Gly Gly Leu Gly
   1               5                  10                  15    
 Ser Val Ala Pro Cys Gln Pro Ala Leu Arg Glu Asp Arg Val Ser His
              20                  25                  30        
 Ala Arg Met Ala Gly His Val Ser Val Leu Val Ser His Phe Pro Pro
          35                  40                  45            
 Ser Val Thr Tyr Leu Gly Ile Pro Gln Gly Leu Leu Glu Cys Asp Cys
      50                  55                  60                
 Pro Leu Pro Ser Cys Leu Gly Tyr Lys Ser Trp Pro Tyr Val Pro Ala
  65                  70                  75                  80
 Val Arg Gly Ser Gly Asn Pro Thr Gln Pro Pro Val Leu Gly Trp Ser
                  85                  90                  95    
 Val Ser Ile His Pro Leu Val Val Ile Glu Ala Ala Leu Pro Val Leu
             100                 105                 110        
 Gly Glu Asp Ile Trp Ala Thr Arg Ala Pro Leu Ala Pro Ser Arg Arg
         115                 120                 125            
 Lys
    



      <210> 259
      <211> 154
      <212> PRT
      <213> Homo sapiens


      <400> 259
 Met His Pro Glu Pro Leu Leu Asn Ser Thr Gln Ser Ala Pro His His
   1               5                  10                  15    
 Phe Pro Asp Ser Phe Gln Ala Thr Pro Phe Cys Phe Asn Gln Ser Leu
              20                  25                  30        
 Ile Pro Gly Ser Pro Ser Asn Ser Ser Ile Leu Ser Gly Ser Leu Asp
          35                  40                  45            
 Tyr Ser Tyr Ser Pro Val Gln Leu Pro Ser Tyr Ala Pro Glu Asn Tyr
      50                  55                  60                
 Asn Ser Pro Ala Ser Leu Asp Thr Arg Thr Cys Gly Tyr Pro Pro Glu
  65                  70                  75                  80
 Asp His Ser Tyr Gln His Leu Ser Ser His Ala Gln Tyr Ser Cys Phe
                  85                  90                  95    
 Ser Ser Ala Thr Thr Ser Ile Cys Cys Cys Ala Ser Cys Glu Ala Glu
             100                 105                 110        
 Asp Leu Asp Ala Leu Gln Ala Ala Glu Tyr Phe Tyr Pro Ser Thr Asp
         115                 120                 125            
 Cys Val Asp Phe Ala Pro Ser Ala Ala Ala Thr Ser Asp Phe Tyr Lys
     130                 135                 140                
 Arg Glu Thr Asn Cys Asp Ile Cys Tyr Ser
 145                 150                



      <210> 260
      <211> 249
      <212> PRT
      <213> Homo sapiens


      <400> 260
 Met Pro Gly Gln Arg Ile Ala Ser Leu Ala Tyr Ser Leu Leu Pro Tyr
   1               5                  10                  15    
 Gly Ala Gly Ile Pro Ala Pro Leu Thr Arg Pro Arg Leu Pro Arg Arg
              20                  25                  30        
 Pro Pro Arg Leu Pro Pro Pro Arg Ser Leu Arg Leu Phe Arg Ile Gln
          35                  40                  45            
 Val Arg Arg Pro Phe Lys Gly Ser Ser Cys Arg Leu Arg Gly Pro Gly
      50                  55                  60                
 Thr Leu Val Pro Asp Ser Gly Asp Pro Asp Gly Phe Arg Ala Asp Pro
  65                  70                  75                  80
 Arg Gly Gln Gly Gly Arg Leu Trp Arg Tyr Pro Glu Ala Asp Ser Gly
                  85                  90                  95    
 Glu Asp Cys Arg Pro Glu Leu Ala Glu Phe Glu Lys Leu Ser Asp Gln
             100                 105                 110        
 Val Lys Ile Ser Glu Glu Ala Leu Arg Ala Asp Gly Phe Gly Asp Asn
         115                 120                 125            
 Pro Phe Tyr His Cys Leu Val Ala Glu Ile Leu Pro Ala Pro Gly Lys
     130                 135                 140                
 Leu Leu Gly Pro Cys Val Val Gly Tyr Gly Ile Tyr Tyr Phe Ile Tyr
 145                 150                 155                 160
 Ser Thr Trp Lys Gly Arg Thr Ile Tyr Leu Glu Asp Ile Tyr Val Met
                 165                 170                 175    
 Pro Glu Tyr Arg Gly Gln Gly Ile Gly Ser Lys Ile Ile Lys Lys Val
             180                 185                 190        
 Ala Glu Val Ala Leu Asp Lys Gly Cys Ser Gln Phe Arg Leu Ala Val
         195                 200                 205            
 Leu Asp Trp Asn Gln Arg Ala Met Asp Leu Tyr Lys Ala Leu Gly Ala
     210                 215                 220                
 Gln Asp Leu Thr Glu Ala Glu Gly Trp His Phe Phe Cys Phe Gln Gly
 225                 230                 235                 240
 Glu Ala Thr Arg Lys Leu Ala Gly Lys
                 245                



      <210> 261
      <211> 167
      <212> PRT
      <213> Homo sapiens


      <400> 261
 Met Lys Cys Val Phe Val Thr Val Gly Thr Thr Ser Phe Asp Asp Leu
   1               5                  10                  15    
 Ile Ala Cys Val Ser Ala Pro Asp Ser Leu Gln Lys Ile Glu Ser Leu
              20                  25                  30        
 Gly Tyr Asn Arg Leu Ile Leu Gln Ile Gly Arg Gly Thr Val Val Pro
          35                  40                  45            
 Glu Pro Phe Ser Thr Glu Ser Phe Thr Leu Asp Val Tyr Arg Tyr Lys
      50                  55                  60                
 Asp Ser Leu Lys Glu Asp Ile Gln Lys Ala Asp Leu Val Ile Ser His
  65                  70                  75                  80
 Ala Gly Lys Gly Ala Gly Ser Cys Leu Glu Thr Leu Glu Lys Gly Lys
                  85                  90                  95    
 Pro Leu Val Val Val Ile Asn Glu Lys Leu Met Asn Asn His Gln Leu
             100                 105                 110        
 Glu Leu Ala Lys Gln Leu His Lys Glu Gly His Leu Phe Tyr Cys Thr
         115                 120                 125            
 Cys Ser Thr Leu Pro Gly Leu Leu Gln Ser Met Asp Leu Ser Thr Leu
     130                 135                 140                
 Lys Cys Tyr Pro Pro Gly Gln Pro Glu Lys Phe Ser Ala Phe Leu Asp
 145                 150                 155                 160
 Lys Val Val Gly Leu Gln Lys
                 165        



      <210> 262
      <211> 442
      <212> PRT
      <213> Homo sapiens


      <400> 262
 Met Ala Ser Val Val Leu Pro Ser Gly Ser Gln Cys Ala Ala Ala Ala
   1               5                  10                  15    
 Ala Ala Ala Ala Pro Pro Gly Leu Arg Leu Arg Leu Leu Leu Leu Leu
              20                  25                  30        
 Phe Ser Ala Ala Ala Leu Ile Pro Thr Gly Asp Gly Gln Asn Leu Phe
          35                  40                  45            
 Thr Lys Asp Val Thr Val Ile Glu Gly Glu Val Ala Thr Ile Ser Cys
      50                  55                  60                
 Gln Val Asn Lys Ser Asp Asp Ser Val Ile Gln Leu Leu Asn Pro Asn
  65                  70                  75                  80
 Arg Gln Thr Ile Tyr Phe Arg Asp Phe Arg Pro Leu Lys Asp Ser Arg
                  85                  90                  95    
 Phe Gln Leu Leu Asn Phe Ser Ser Ser Glu Leu Lys Val Ser Leu Thr
             100                 105                 110        
 Asn Val Ser Ile Ser Asp Glu Gly Arg Tyr Phe Cys Gln Leu Tyr Thr
         115                 120                 125            
 Asp Pro Pro Gln Glu Ser Tyr Thr Thr Ile Thr Val Leu Val Pro Pro
     130                 135                 140                
 Arg Asn Leu Met Ile Asp Ile Gln Lys Asp Thr Ala Val Glu Gly Glu
 145                 150                 155                 160
 Glu Ile Glu Val Asn Cys Thr Ala Met Ala Ser Lys Pro Ala Thr Thr
                 165                 170                 175    
 Ile Arg Trp Phe Lys Gly Asn Thr Glu Leu Lys Gly Lys Ser Glu Val
             180                 185                 190        
 Glu Glu Trp Ser Asp Met Tyr Thr Val Thr Ser Gln Leu Met Leu Lys
         195                 200                 205            
 Val His Lys Glu Asp Asp Gly Val Pro Val Ile Cys Gln Val Glu His
     210                 215                 220                
 Pro Ala Val Thr Gly Asn Leu Gln Thr Gln Arg Tyr Leu Glu Val Gln
 225                 230                 235                 240
 Tyr Lys Pro Gln Val His Ile Gln Met Thr Tyr Pro Leu Gln Gly Leu
                 245                 250                 255    
 Thr Arg Glu Gly Asp Ala Leu Glu Leu Thr Cys Glu Ala Ile Gly Lys
             260                 265                 270        
 Pro Gln Pro Val Met Val Thr Trp Val Arg Val Asp Asp Glu Met Pro
         275                 280                 285            
 Gln His Ala Val Leu Ser Gly Pro Asn Leu Phe Ile Asn Asn Leu Asn
     290                 295                 300                
 Lys Thr Asp Asn Gly Thr Tyr Arg Cys Glu Ala Ser Asn Ile Val Gly
 305                 310                 315                 320
 Lys Ala His Ser Asp Tyr Met Leu Tyr Val Tyr Asp Pro Pro Thr Thr
                 325                 330                 335    
 Ile Pro Pro Pro Thr Thr Thr Thr Thr Thr Thr Thr Thr Thr Thr Thr
             340                 345                 350        
 Thr Ile Leu Thr Ile Ile Thr Asp Ser Arg Ala Gly Glu Glu Gly Ser
         355                 360                 365            
 Ile Arg Ala Val Asp His Ala Val Ile Gly Gly Val Val Ala Val Val
     370                 375                 380                
 Val Phe Ala Met Leu Cys Leu Leu Ile Ile Leu Gly Arg Tyr Phe Ala
 385                 390                 395                 400
 Arg His Lys Gly Thr Tyr Phe Thr His Glu Ala Lys Gly Ala Asp Asp
                 405                 410                 415    
 Ala Ala Asp Ala Asp Thr Ala Ile Ile Asn Ala Glu Gly Gly Gln Asn
             420                 425                 430        
 Asn Ser Glu Glu Lys Lys Glu Tyr Phe Ile
         435                 440        



      <210> 263
      <211> 62
      <212> PRT
      <213> Homo sapiens


      <400> 263
 Met Asp Pro Asn Cys Ser Cys Ala Ala Ala Gly Val Ser Cys Thr Cys
   1               5                  10                  15    
 Ala Ser Ser Cys Lys Cys Lys Glu Cys Lys Cys Thr Ser Cys Lys Lys
              20                  25                  30        
 Ser Cys Cys Ser Cys Cys Pro Val Gly Cys Ala Lys Cys Ala Gln Gly
          35                  40                  45            
 Cys Ile Cys Lys Gly Ala Ser Glu Lys Cys Ser Cys Cys Ala
      50                  55                  60        



      <210> 264
      <211> 640
      <212> PRT
      <213> Homo sapiens


      <400> 264
 Met Glu Ser Val Val Arg Arg Cys Pro Phe Leu Ser Arg Val Pro Gln
   1               5                  10                  15    
 Ala Phe Leu Gln Lys Ala Gly Lys Ser Leu Leu Phe Tyr Ala Gln Asn
              20                  25                  30        
 Cys Pro Lys Met Met Glu Val Gly Ala Lys Pro Ala Pro Arg Ala Leu
          35                  40                  45            
 Ser Thr Ala Ala Val His Tyr Gln Gln Ile Lys Glu Thr Pro Pro Ala
      50                  55                  60                
 Ser Glu Lys Asp Lys Thr Ala Lys Ala Lys Val Gln Gln Thr Pro Asp
  65                  70                  75                  80
 Gly Ser Gln Gln Ser Pro Asp Gly Thr Gln Leu Pro Ser Gly His Pro
                  85                  90                  95    
 Leu Pro Ala Thr Ser Gln Gly Thr Ala Ser Lys Cys Pro Phe Leu Ala
             100                 105                 110        
 Ala Gln Met Asn Gln Arg Gly Ser Ser Val Phe Cys Lys Ala Ser Leu
         115                 120                 125            
 Glu Leu Gln Glu Asp Val Gln Glu Met Asn Ala Val Arg Lys Glu Val
     130                 135                 140                
 Ala Glu Thr Ser Ala Gly Pro Ser Val Val Ser Val Lys Thr Asp Gly
 145                 150                 155                 160
 Gly Asp Pro Ser Gly Leu Leu Lys Asn Phe Gln Asp Ile Met Gln Lys
                 165                 170                 175    
 Gln Arg Pro Glu Arg Val Ser His Leu Leu Gln Asp Asn Leu Pro Lys
             180                 185                 190        
 Ser Val Ser Thr Phe Gln Tyr Asp Arg Phe Phe Glu Lys Lys Ile Asp
         195                 200                 205            
 Glu Lys Lys Asn Asp His Thr Tyr Arg Val Phe Lys Thr Val Asn Arg
     210                 215                 220                
 Arg Ala His Ile Phe Pro Met Ala Asp Asp Tyr Ser Asp Ser Leu Ile
 225                 230                 235                 240
 Thr Lys Lys Gln Val Ser Val Trp Cys Ser Asn Asp Tyr Leu Gly Met
                 245                 250                 255    
 Ser Arg His Pro Arg Val Cys Gly Ala Val Met Asp Thr Leu Lys Gln
             260                 265                 270        
 His Gly Ala Gly Ala Gly Gly Thr Arg Asn Ile Ser Gly Thr Ser Lys
         275                 280                 285            
 Phe His Val Asp Leu Glu Arg Glu Leu Ala Asp Leu His Gly Lys Asp
     290                 295                 300                
 Ala Ala Leu Leu Phe Ser Ser Cys Phe Val Ala Asn Asp Ser Thr Leu
 305                 310                 315                 320
 Phe Thr Leu Ala Lys Met Met Pro Gly Cys Glu Ile Tyr Ser Asp Ser
                 325                 330                 335    
 Gly Asn His Ala Ser Met Ile Gln Gly Ile Arg Asn Ser Arg Val Pro
             340                 345                 350        
 Lys Tyr Ile Phe Arg His Asn Asp Val Ser His Leu Arg Glu Leu Leu
         355                 360                 365            
 Gln Arg Ser Asp Pro Ser Val Pro Lys Ile Val Ala Phe Glu Thr Val
     370                 375                 380                
 His Ser Met Asp Gly Ala Val Cys Pro Leu Glu Glu Leu Cys Asp Val
 385                 390                 395                 400
 Ala His Glu Phe Gly Ala Ile Thr Phe Val Asp Glu Val His Ala Val
                 405                 410                 415    
 Gly Leu Tyr Gly Ala Arg Gly Gly Gly Ile Gly Asp Arg Asp Gly Val
             420                 425                 430        
 Met Pro Lys Met Asp Ile Ile Ser Gly Thr Leu Gly Lys Ala Phe Gly
         435                 440                 445            
 Cys Val Gly Gly Tyr Ile Ala Ser Thr Ser Ser Leu Ile Asp Thr Val
     450                 455                 460                
 Arg Ser Tyr Ala Ala Gly Phe Ile Phe Thr Thr Ser Leu Pro Pro Met
 465                 470                 475                 480
 Leu Leu Ala Gly Ala Leu Glu Ser Val Arg Ile Leu Lys Ser Ala Glu
                 485                 490                 495    
 Gly Arg Val Leu Arg Arg Gln His Gln Arg Asn Val Lys Leu Met Arg
             500                 505                 510        
 Gln Met Leu Met Asp Ala Gly Leu Pro Val Val His Cys Pro Ser His
         515                 520                 525            
 Ile Ile Pro Val Arg Val Ala Asp Ala Ala Lys Asn Thr Glu Val Cys
     530                 535                 540                
 Asp Glu Leu Met Ser Arg His Asn Ile Tyr Val Gln Ala Ile Asn Tyr
 545                 550                 555                 560
 Pro Thr Val Pro Arg Gly Glu Glu Leu Leu Arg Ile Ala Pro Thr Pro
                 565                 570                 575    
 His His Thr Pro Gln Met Met Asn Tyr Phe Leu Glu Asn Leu Leu Val
             580                 585                 590        
 Thr Trp Lys Gln Val Gly Leu Glu Leu Lys Pro His Ser Ser Ala Glu
         595                 600                 605            
 Cys Asn Phe Cys Arg Arg Pro Leu His Phe Glu Val Met Ser Glu Arg
     610                 615                 620                
 Glu Lys Ser Tyr Phe Ser Gly Leu Ser Lys Leu Val Ser Ala Gln Ala
 625                 630                 635                 640





      <210> 265
      <211> 228
      <212> PRT
      <213> Homo sapiens


      <400> 265
 Met Met Pro Glu Ile Asn Thr Asn His Leu Asp Lys Gln Gln Val Gln
   1               5                  10                  15    
 Leu Leu Ala Glu Met Cys Ile Leu Ile Asp Glu Asn Asp Asn Lys Ile
              20                  25                  30        
 Gly Ala Glu Thr Lys Lys Asn Cys His Leu Asn Glu Asn Ile Glu Lys
          35                  40                  45            
 Gly Leu Leu His Arg Ala Phe Ser Val Phe Leu Phe Asn Thr Glu Asn
      50                  55                  60                
 Lys Leu Leu Leu Gln Gln Arg Ser Asp Ala Lys Ile Thr Phe Pro Gly
  65                  70                  75                  80
 Cys Phe Thr Asn Thr Cys Cys Ser His Pro Leu Ser Asn Pro Ala Glu
                  85                  90                  95    
 Leu Glu Glu Ser Asp Ala Leu Gly Val Arg Arg Ala Ala Gln Arg Arg
             100                 105                 110        
 Leu Lys Ala Glu Leu Gly Ile Pro Leu Glu Glu Val Pro Pro Glu Glu
         115                 120                 125            
 Ile Asn Tyr Leu Thr Arg Ile His Tyr Lys Ala Gln Ser Asp Gly Ile
     130                 135                 140                
 Trp Gly Glu His Glu Ile Asp Tyr Ile Leu Leu Val Arg Lys Asn Val
 145                 150                 155                 160
 Thr Leu Asn Pro Asp Pro Asn Glu Ile Lys Ser Tyr Cys Tyr Val Ser
                 165                 170                 175    
 Lys Glu Glu Leu Lys Glu Leu Leu Lys Lys Ala Ala Ser Gly Glu Ile
             180                 185                 190        
 Lys Ile Thr Pro Trp Phe Lys Ile Ile Ala Ala Thr Phe Leu Phe Lys
         195                 200                 205            
 Trp Trp Asp Asn Leu Asn His Leu Asn Gln Phe Val Asp His Glu Lys
     210                 215                 220                
 Ile Tyr Arg Met
 225            



      <210> 266
      <211> 490
      <212> PRT
      <213> Homo sapiens


      <400> 266
 Met Thr Ser Arg Ala Ser Glu Leu Ser Pro Gly Arg Ser Val Thr Ala
   1               5                  10                  15    
 Gly Ile Ile Ile Val Gly Asp Glu Ile Leu Lys Gly His Thr Gln Asp
              20                  25                  30        
 Thr Asn Thr Phe Phe Leu Cys Arg Thr Leu Arg Ser Leu Gly Val Gln
          35                  40                  45            
 Val Cys Arg Val Ser Val Val Pro Asp Glu Val Ala Thr Ile Ala Ala
      50                  55                  60                
 Glu Val Thr Ser Phe Ser Asn Arg Phe Thr His Val Leu Thr Ala Gly
  65                  70                  75                  80
 Gly Ile Gly Pro Thr His Asp Asp Val Thr Phe Glu Ala Val Ala Gln
                  85                  90                  95    
 Ala Phe Gly Asp Glu Leu Lys Pro His Pro Lys Leu Glu Ala Ala Thr
             100                 105                 110        
 Lys Ala Leu Gly Gly Glu Gly Trp Glu Lys Leu Ser Leu Val Pro Ser
         115                 120                 125            
 Ser Ala Arg Leu His Tyr Gly Thr Asp Pro Cys Thr Gly Gln Pro Phe
     130                 135                 140                
 Arg Phe Pro Leu Val Ser Val Arg Asn Val Tyr Leu Phe Pro Gly Ile
 145                 150                 155                 160
 Pro Glu Leu Leu Arg Arg Val Leu Glu Gly Met Lys Gly Leu Phe Gln
                 165                 170                 175    
 Asn Pro Ala Val Gln Phe His Ser Lys Glu Leu Tyr Val Ala Ala Asp
             180                 185                 190        
 Glu Ala Ser Ile Ala Pro Ile Leu Ala Glu Ala Gln Ala His Phe Gly
         195                 200                 205            
 Arg Arg Leu Gly Leu Gly Ser Tyr Pro Asp Trp Gly Ser Asn Tyr Tyr
     210                 215                 220                
 Gln Val Lys Leu Thr Leu Asp Ser Glu Glu Glu Gly Pro Leu Glu Glu
 225                 230                 235                 240
 Cys Leu Ala Tyr Leu Thr Ala Arg Leu Pro Gln Gly Ser Leu Val Pro
                 245                 250                 255    
 Tyr Met Pro Asn Ala Val Glu Gln Ala Ser Glu Ala Val Tyr Lys Leu
             260                 265                 270        
 Ala Glu Ser Gly Ser Ser Leu Gly Lys Lys Val Ala Gly Ala Leu Gln
         275                 280                 285            
 Thr Ile Glu Thr Ser Leu Ala Gln Tyr Ser Leu Thr Gln Leu Cys Val
     290                 295                 300                
 Gly Phe Asn Gly Gly Lys Asp Cys Thr Ala Leu Leu His Leu Phe His
 305                 310                 315                 320
 Ala Ala Val Gln Arg Lys Leu Pro Asp Val Pro Asn Pro Leu Gln Ile
                 325                 330                 335    
 Leu Tyr Ile Arg Ser Ile Ser Pro Phe Pro Glu Leu Glu Gln Phe Leu
             340                 345                 350        
 Gln Asp Thr Ile Lys Arg Tyr Asn Leu Gln Met Leu Glu Ala Glu Gly
         355                 360                 365            
 Ser Met Lys Gln Ala Leu Gly Glu Leu Gln Ala Arg His Pro Gln Leu
     370                 375                 380                
 Glu Ala Val Leu Met Gly Thr Arg Arg Thr Asp Pro Tyr Ser Cys Ser
 385                 390                 395                 400
 Leu Cys Pro Phe Ser Pro Thr Asp Pro Gly Trp Pro Ala Phe Met Arg
                 405                 410                 415    
 Ile Asn Pro Leu Leu Asp Trp Thr Tyr Arg Asp Ile Trp Asp Phe Leu
             420                 425                 430        
 Arg Gln Leu Phe Val Pro Tyr Cys Ile Leu Tyr Asp Arg Gly Tyr Thr
         435                 440                 445            
 Ser Leu Gly Ser Arg Glu Asn Thr Val Arg Asn Pro Ala Leu Lys Cys
     450                 455                 460                
 Leu Ser Pro Gly Gly His Pro Thr Tyr Arg Pro Ala Tyr Leu Leu Glu
 465                 470                 475                 480
 Asn Glu Glu Glu Glu Arg Asn Ser Arg Thr
                 485                 490



      <210> 267
      <211> 137
      <212> PRT
      <213> Homo sapiens


      <400> 267
 Met Arg Pro Gln Gln Ala Pro Val Ser Gly Lys Val Phe Ile Gln Arg
   1               5                  10                  15    
 Asp Tyr Ser Ser Gly Thr Arg Cys Gln Phe Gln Thr Lys Phe Pro Ala
              20                  25                  30        
 Glu Leu Glu Asn Arg Ile Asp Arg Gln Gln Phe Glu Glu Thr Val Arg
          35                  40                  45            
 Thr Leu Asn Asn Leu Tyr Ala Glu Ala Glu Lys Leu Gly Gly Gln Ser
      50                  55                  60                
 Tyr Leu Glu Gly Cys Leu Ala Cys Leu Thr Ala Tyr Thr Ile Phe Leu
  65                  70                  75                  80
 Cys Met Glu Thr His Tyr Glu Lys Val Leu Lys Lys Val Ser Lys Tyr
                  85                  90                  95    
 Ile Gln Glu Gln Asn Glu Lys Ile Tyr Ala Pro Gln Gly Leu Leu Leu
             100                 105                 110        
 Thr Asp Pro Ile Glu Arg Gly Leu Arg Val Ile Glu Ile Thr Ile Tyr
         115                 120                 125            
 Glu Asp Arg Gly Met Ser Ser Gly Arg
     130                 135        



      <210> 268
      <211> 71
      <212> PRT
      <213> Homo sapiens


      <400> 268
 Met Glu Met His Phe Ile Met Cys Leu Ser Lys Pro Arg Leu Ser Tyr
   1               5                  10                  15    
 Asn Asp Asp Val Leu Thr Lys Asp Ala Gly Glu Cys Val Ile Cys Leu
              20                  25                  30        
 Glu Glu Leu Leu Gln Gly Asp Thr Ile Ala Arg Leu Pro Cys Leu Cys
          35                  40                  45            
 Ile Tyr His Lys Ser Cys Ile Asp Ser Trp Phe Glu Val Asn Arg Ser
      50                  55                  60                
 Cys Pro Glu His Pro Ala Asp
  65                  70    



      <210> 269
      <211> 382
      <212> PRT
      <213> Homo sapiens


      <400> 269
 Met Thr Glu Phe Trp Leu Ile Ser Ala Pro Gly Glu Lys Thr Cys Gln
   1               5                  10                  15    
 Gln Thr Trp Glu Lys Leu His Ala Ala Thr Ser Lys Asn Asn Asn Leu
              20                  25                  30        
 Ala Val Thr Ser Lys Phe Asn Ile Pro Asp Leu Lys Val Gly Thr Leu
          35                  40                  45            
 Asp Val Leu Val Gly Leu Ser Asp Glu Leu Ala Lys Leu Asp Ala Phe
      50                  55                  60                
 Val Glu Gly Val Val Lys Lys Val Ala Gln Tyr Met Ala Asp Val Leu
  65                  70                  75                  80
 Glu Asp Ser Lys Asp Lys Val Gln Glu Asn Leu Leu Ala Asn Gly Val
                  85                  90                  95    
 Asp Leu Val Thr Tyr Ile Thr Arg Phe Gln Trp Asp Met Ala Lys Tyr
             100                 105                 110        
 Pro Ile Lys Gln Ser Leu Lys Asn Ile Ser Glu Ile Ile Ala Lys Gly
         115                 120                 125            
 Val Thr Gln Ile Asp Asn Asp Leu Lys Ser Arg Ala Ser Ala Tyr Asn
     130                 135                 140                
 Asn Leu Lys Gly Asn Leu Gln Asn Leu Glu Arg Lys Asn Ala Gly Ser
 145                 150                 155                 160
 Leu Leu Thr Arg Ser Leu Ala Glu Ile Val Lys Lys Asp Asp Phe Val
                 165                 170                 175    
 Leu Asp Ser Glu Tyr Leu Val Thr Leu Leu Val Val Val Pro Lys Leu
             180                 185                 190        
 Asn His Asn Asp Trp Ile Lys Gln Tyr Glu Thr Leu Ala Glu Met Val
         195                 200                 205            
 Val Pro Arg Ser Ser Asn Val Leu Ser Glu Asp Gln Asp Ser Tyr Leu
     210                 215                 220                
 Cys Asn Val Thr Leu Phe Arg Lys Ala Val Asp Asp Phe Arg His Lys
 225                 230                 235                 240
 Ala Arg Glu Asn Lys Phe Ile Val Arg Asp Phe Gln Tyr Asn Glu Glu
                 245                 250                 255    
 Glu Met Lys Ala Asp Lys Glu Glu Met Asn Arg Leu Ser Thr Asp Lys
             260                 265                 270        
 Lys Lys Gln Phe Gly Pro Leu Val Arg Trp Leu Lys Val Asn Phe Ser
         275                 280                 285            
 Glu Ala Phe Ile Ala Trp Ile His Val Lys Ala Leu Arg Val Phe Val
     290                 295                 300                
 Glu Ser Val Leu Arg Tyr Gly Leu Pro Val Asn Phe Gln Ala Met Leu
 305                 310                 315                 320
 Leu Gln Pro Asn Lys Lys Thr Leu Lys Lys Leu Arg Glu Val Leu His
                 325                 330                 335    
 Glu Leu Tyr Lys His Leu Asp Ser Ser Ala Ala Ala Ile Ile Asp Ala
             340                 345                 350        
 Pro Met Asp Ile Pro Gly Leu Asn Leu Ser Gln Gln Glu Tyr Tyr Pro
         355                 360                 365            
 Tyr Val Tyr Tyr Lys Ile Asp Cys Asn Leu Leu Glu Phe Lys
     370                 375                 380        



      <210> 270
      <211> 196
      <212> PRT
      <213> Homo sapiens


      <400> 270
 Met Ser His Gly His Ser His Gly Gly Gly Gly Cys Arg Cys Ala Ala
   1               5                  10                  15    
 Glu Arg Glu Glu Pro Pro Glu Gln Arg Gly Leu Ala Tyr Gly Leu Tyr
              20                  25                  30        
 Leu Arg Ile Asp Leu Glu Arg Leu Gln Cys Leu Asn Glu Ser Arg Glu
          35                  40                  45            
 Gly Ser Gly Arg Gly Val Phe Lys Pro Trp Glu Glu Arg Thr Asp Arg
      50                  55                  60                
 Ser Arg Phe Thr Gly Asn Val Lys Leu Lys Gly Ile Ile Ile Met Gly
  65                  70                  75                  80
 Glu Asp Asp Asp Ser His Pro Ser Glu Met Arg Leu Tyr Lys Asn Ile
                  85                  90                  95    
 Pro Gln Met Ser Phe Asp Asp Thr Glu Arg Glu Pro Asp Gln Thr Phe
             100                 105                 110        
 Ser Leu Asn Arg Asp Leu Thr Gly Glu Leu Glu Tyr Ala Thr Lys Ile
         115                 120                 125            
 Ser Arg Phe Ser Asn Val Tyr His Leu Ser Ile His Ile Ser Lys Asn
     130                 135                 140                
 Phe Gly Ala Asp Thr Thr Lys Val Phe Tyr Ile Gly Leu Arg Gly Glu
 145                 150                 155                 160
 Trp Thr Glu Leu Arg Arg His Glu Val Thr Ile Cys Asn Tyr Glu Ala
                 165                 170                 175    
 Ser Ala Asn Pro Ala Asp His Arg Val His Gln Val Thr Pro Gln Thr
             180                 185                 190        
 His Phe Ile Ser
         195    



      <210> 271
      <211> 339
      <212> PRT
      <213> Homo sapiens


      <400> 271
 Met Ala Val Ala Gln Gln Leu Arg Ala Glu Ser Asp Phe Glu Gln Leu
   1               5                  10                  15    
 Pro Asp Asp Val Ala Ile Ser Ala Asn Ile Ala Asp Ile Glu Glu Lys
              20                  25                  30        
 Arg Gly Phe Thr Ser His Phe Val Phe Val Ile Glu Val Lys Thr Lys
          35                  40                  45            
 Gly Gly Ser Lys Tyr Leu Ile Tyr Arg Arg Tyr Arg Gln Phe His Ala
      50                  55                  60                
 Leu Gln Ser Lys Leu Glu Glu Arg Phe Gly Pro Asp Ser Lys Ser Ser
  65                  70                  75                  80
 Ala Leu Ala Cys Thr Leu Pro Thr Leu Pro Ala Lys Val Tyr Val Gly
                  85                  90                  95    
 Val Lys Gln Glu Ile Ala Glu Met Arg Ile Pro Ala Leu Asn Ala Tyr
             100                 105                 110        
 Met Lys Ser Leu Leu Ser Leu Pro Val Trp Val Leu Met Asp Glu Asp
         115                 120                 125            
 Val Arg Ile Phe Phe Tyr Gln Ser Pro Tyr Asp Ser Glu Gln Val Pro
     130                 135                 140                
 Gln Ala Leu Arg Arg Leu Arg Pro Arg Thr Arg Lys Val Lys Ser Val
 145                 150                 155                 160
 Ser Pro Gln Gly Asn Ser Val Asp Arg Met Ala Ala Pro Arg Ala Glu
                 165                 170                 175    
 Ala Leu Phe Asp Phe Thr Gly Asn Ser Lys Leu Glu Leu Asn Phe Lys
             180                 185                 190        
 Ala Gly Asp Val Ile Phe Leu Leu Ser Arg Ile Asn Lys Asp Trp Leu
         195                 200                 205            
 Glu Gly Thr Val Arg Gly Ala Thr Gly Ile Phe Pro Leu Ser Phe Val
     210                 215                 220                
 Lys Ile Leu Lys Asp Phe Pro Glu Glu Asp Asp Pro Thr Asn Trp Leu
 225                 230                 235                 240
 Arg Cys Tyr Tyr Tyr Glu Asp Thr Ile Ser Thr Ile Lys Asp Ile Ala
                 245                 250                 255    
 Val Glu Glu Asp Leu Ser Ser Thr Pro Leu Leu Lys Asp Leu Leu Glu
             260                 265                 270        
 Leu Thr Arg Arg Glu Phe Gln Arg Glu Asp Ile Ala Leu Asn Tyr Arg
         275                 280                 285            
 Asp Ala Glu Gly Asp Leu Val Arg Leu Leu Ser Asp Glu Asp Val Ala
     290                 295                 300                
 Leu Met Val Arg Gln Ala Arg Gly Leu Pro Ser Gln Lys Arg Leu Phe
 305                 310                 315                 320
 Pro Trp Lys Leu His Ile Thr Gln Lys Asp Asn Tyr Arg Val Tyr Asn
                 325                 330                 335    
 Thr Met Pro
            



      <210> 272
      <211> 326
      <212> PRT
      <213> Homo sapiens


      <400> 272
 Met Ala Val Ala Gln Gln Leu Arg Ala Glu Ser Asp Phe Glu Gln Leu
   1               5                  10                  15    
 Pro Asp Asp Val Ala Ile Ser Ala Asn Ile Ala Asp Ile Glu Glu Lys
              20                  25                  30        
 Arg Gly Phe Thr Ser His Phe Val Phe Val Ile Glu Val Lys Thr Lys
          35                  40                  45            
 Gly Gly Ser Lys Tyr Leu Ile Tyr Arg Arg Tyr Arg Gln Phe His Ala
      50                  55                  60                
 Leu Gln Ser Lys Leu Glu Glu Arg Phe Gly Pro Asp Ser Lys Ser Ser
  65                  70                  75                  80
 Ala Leu Ala Cys Thr Leu Pro Thr Leu Pro Ala Lys Val Tyr Val Gly
                  85                  90                  95    
 Val Lys Gln Glu Ile Ala Glu Met Arg Ile Pro Ala Leu Asn Ala Tyr
             100                 105                 110        
 Met Lys Ser Leu Leu Ser Leu Pro Val Trp Val Leu Met Asp Glu Asp
         115                 120                 125            
 Val Arg Ile Phe Phe Tyr Gln Ser Pro Tyr Asp Ser Glu Gln Val Pro
     130                 135                 140                
 Gln Ala Leu Arg Arg Leu Arg Pro Arg Thr Arg Lys Val Lys Ser Val
 145                 150                 155                 160
 Ser Pro Gln Gly Asn Ser Val Asp Arg Met Ala Ala Pro Arg Ala Glu
                 165                 170                 175    
 Ala Leu Phe Asp Phe Thr Gly Asn Ser Lys Leu Glu Leu Asn Phe Lys
             180                 185                 190        
 Ala Gly Asp Val Ile Phe Leu Leu Ser Arg Ile Asn Lys Asp Trp Leu
         195                 200                 205            
 Glu Gly Thr Val Arg Gly Ala Thr Gly Ile Phe Pro Leu Ser Phe Val
     210                 215                 220                
 Lys Ile Leu Lys Asp Phe Pro Glu Glu Asp Asp Pro Thr Asn Trp Leu
 225                 230                 235                 240
 Arg Cys Tyr Tyr Tyr Glu Asp Thr Ile Ser Thr Pro Leu Leu Lys Asp
                 245                 250                 255    
 Leu Leu Glu Leu Thr Arg Arg Glu Phe Gln Arg Glu Asp Ile Ala Leu
             260                 265                 270        
 Asn Tyr Arg Asp Ala Glu Gly Asp Leu Val Arg Leu Leu Ser Asp Glu
         275                 280                 285            
 Asp Val Ala Leu Met Val Arg Gln Ala Arg Gly Leu Pro Ser Gln Lys
     290                 295                 300                
 Arg Leu Phe Pro Trp Lys Leu His Ile Thr Gln Lys Asp Asn Tyr Arg
 305                 310                 315                 320
 Val Tyr Asn Thr Met Pro
                 325    



      <210> 273
      <211> 85
      <212> PRT
      <213> Homo sapiens


      <400> 273
 Met Gly Asp Arg Ile Leu Pro Phe Leu Ala Ala Val Trp Leu Cys Gln
   1               5                  10                  15    
 Leu Ala Phe Cys Thr Asp Pro Leu Thr Thr Val Arg Glu Gln Cys Glu
              20                  25                  30        
 Gln Leu Glu Lys Cys Val Lys Ala Arg Glu Arg Leu Glu Leu Cys Asp
          35                  40                  45            
 Glu Arg Val Ser Ser Arg Ser His Thr Glu Glu Asp Cys Thr Glu Glu
      50                  55                  60                
 Leu Phe Asp Phe Leu His Ala Arg Asp His Cys Val Ala His Lys Leu
  65                  70                  75                  80
 Phe Asn Asn Leu Lys
                  85



      <210> 274
      <211> 91
      <212> PRT
      <213> Homo sapiens


      <400> 274
 Met Arg Ser Leu Leu Ser Val Gly Leu Pro Pro Ile Pro Ile Gly Arg
   1               5                  10                  15    
 Gly Cys His Phe Thr Leu Ile Thr Val Phe Leu Tyr Cys Thr Arg Val
              20                  25                  30        
 Gly Arg Lys Gly Thr Cys Val Ala Pro Pro Asp Leu Pro Val Ser Ala
          35                  40                  45            
 Ser Thr Phe Gly Thr Ser Cys Leu Arg Gln Glu Ala Ala Ala Glu Gly
      50                  55                  60                
 Arg Pro Val Val Arg Phe Asp Lys Ile Lys Ala Ala Gly Lys Trp Thr
  65                  70                  75                  80
 Val Arg Phe Arg Glu Met Glu Gly Ser Trp Ile
                  85                  90    



      <210> 275
      <211> 290
      <212> PRT
      <213> Homo sapiens


      <400> 275
 Met Gly Ser Ser Lys Lys Val Thr Leu Ser Val Leu Ser Arg Glu Gln
   1               5                  10                  15    
 Ser Glu Gly Val Gly Ala Arg Val Arg Arg Ser Ile Gly Arg Pro Glu
              20                  25                  30        
 Leu Lys Asn Leu Asp Pro Phe Leu Leu Phe Asp Glu Phe Lys Gly Gly
          35                  40                  45            
 Arg Pro Gly Gly Phe Pro Asp His Pro His Arg Gly Phe Glu Thr Val
      50                  55                  60                
 Ser Tyr Leu Leu Glu Gly Gly Ser Met Ala His Glu Asp Phe Cys Gly
  65                  70                  75                  80
 His Thr Gly Lys Met Asn Pro Gly Asp Leu Gln Trp Met Thr Ala Gly
                  85                  90                  95    
 Arg Gly Ile Leu His Ala Glu Met Pro Cys Ser Glu Glu Pro Ala His
             100                 105                 110        
 Gly Leu Gln Leu Trp Val Asn Leu Arg Ser Ser Glu Lys Met Val Glu
         115                 120                 125            
 Pro Gln Tyr Gln Glu Leu Lys Ser Glu Glu Ile Pro Lys Pro Ser Lys
     130                 135                 140                
 Asp Gly Val Thr Val Ala Val Ile Ser Gly Glu Ala Leu Gly Ile Lys
 145                 150                 155                 160
 Ser Lys Val Tyr Thr Arg Thr Pro Thr Leu Tyr Leu Asp Phe Lys Leu
                 165                 170                 175    
 Asp Pro Gly Ala Lys His Ser Gln Pro Ile Pro Lys Gly Trp Thr Ser
             180                 185                 190        
 Phe Ile Tyr Thr Ile Ser Gly Asp Val Tyr Ile Gly Pro Asp Asp Ala
         195                 200                 205            
 Gln Gln Lys Ile Glu Pro His His Thr Ala Val Leu Gly Glu Gly Asp
     210                 215                 220                
 Ser Val Gln Val Glu Asn Lys Asp Pro Lys Arg Ser His Phe Val Leu
 225                 230                 235                 240
 Ile Ala Gly Glu Pro Leu Arg Glu Pro Val Ile Gln His Gly Pro Phe
                 245                 250                 255    
 Val Met Asn Thr Asn Glu Glu Ile Ser Gln Ala Ile Leu Asp Phe Arg
             260                 265                 270        
 Asn Ala Lys Asn Gly Phe Glu Arg Ala Lys Thr Trp Lys Ser Lys Ile
         275                 280                 285            
 Gly Asn
     290



      <210> 276
      <211> 637
      <212> PRT
      <213> Homo sapiens


      <400> 276
 Met Ala Lys Glu Gly Arg Tyr Glu Cys Ile Cys Gly Trp Ala Phe Val
   1               5                  10                  15    
 Lys Asp Val His Glu Asp Ser Ile Thr Val Ala Phe Glu Asn Asn Trp
              20                  25                  30        
 Gln Pro Asp Arg Gln Ile Pro Phe His Asp Val Arg Phe Pro Pro Pro
          35                  40                  45            
 Val Gly Tyr Asn Lys Asp Ile Asn Glu Ser Asp Glu Val Glu Phe Tyr
      50                  55                  60                
 Val Ile Glu Tyr Ala Ala Cys Asp Ala Thr Tyr Asn Glu Ile Val Thr
  65                  70                  75                  80
 Ile Glu Arg Leu Arg Ser Val Asn Pro Asn Lys Pro Ala Thr Lys Asp
                  85                  90                  95    
 Thr Phe His Lys Ile Lys Leu Asp Val Pro Glu Asp Leu Arg Gln Met
             100                 105                 110        
 Cys Ala Lys Glu Ala Ala His Lys Asp Phe Lys Lys Ala Val Gly Ala
         115                 120                 125            
 Phe Ser Val Thr Tyr Asp Pro Glu Asn Tyr Gln Leu Val Ile Leu Ser
     130                 135                 140                
 Ile Asn Glu Val Thr Ser Lys Arg Ala His Met Leu Ile Asp Met His
 145                 150                 155                 160
 Phe Arg Ser Leu Arg Thr Lys Leu Ser Leu Ile Met Arg Asn Glu Glu
                 165                 170                 175    
 Ala Ser Lys Gln Leu Glu Ser Ser Arg Gln Leu Ala Ser Arg Phe His
             180                 185                 190        
 Glu Gln Phe Ile Val Arg Glu Asp Leu Met Gly Leu Ala Ile Gly Thr
         195                 200                 205            
 His Gly Ala Asn Ile Gln Gln Ala Arg Lys Val Pro Gly Val Thr Ala
     210                 215                 220                
 Ile Asp Leu Asp Glu Asp Thr Cys Thr Phe His Ile Tyr Gly Glu Asp
 225                 230                 235                 240
 Gln Asp Ala Val Lys Lys Ala Arg Ser Phe Leu Glu Phe Ala Glu Asp
                 245                 250                 255    
 Val Ile Gln Val Pro Arg Asn Leu Val Gly Lys Val Ile Gly Lys Asn
             260                 265                 270        
 Gly Lys Leu Ile Gln Glu Ile Val Asp Lys Ser Gly Val Val Arg Val
         275                 280                 285            
 Arg Ile Glu Ala Glu Asn Glu Lys Asn Val Pro Gln Glu Glu Glu Ile
     290                 295                 300                
 Met Pro Pro Asn Ser Leu Pro Ser Asn Asn Ser Arg Val Gly Pro Asn
 305                 310                 315                 320
 Ala Pro Glu Glu Lys Lys His Leu Asp Ile Lys Glu Asn Ser Thr His
                 325                 330                 335    
 Phe Ser Gln Pro Asn Ser Thr Lys Val Gln Arg Val Leu Val Ala Ser
             340                 345                 350        
 Ser Val Val Ala Gly Glu Ser Gln Lys Pro Glu Leu Lys Ala Trp Gln
         355                 360                 365            
 Gly Met Val Pro Phe Val Phe Val Gly Thr Lys Asp Ser Ile Ala Asn
     370                 375                 380                
 Ala Thr Val Leu Leu Asp Tyr His Leu Asn Tyr Leu Lys Glu Val Asp
 385                 390                 395                 400
 Gln Leu Arg Leu Glu Arg Leu Gln Ile Asp Glu Gln Leu Arg Gln Ile
                 405                 410                 415    
 Gly Ala Ser Ser Arg Pro Pro Pro Asn Arg Thr Asp Lys Glu Lys Ser
             420                 425                 430        
 Tyr Val Thr Asp Asp Gly Gln Gly Met Gly Arg Gly Ser Arg Pro Tyr
         435                 440                 445            
 Arg Asn Arg Gly His Gly Arg Arg Gly Pro Gly Tyr Thr Ser Gly Thr
     450                 455                 460                
 Asn Ser Glu Ala Ser Asn Ala Ser Glu Thr Glu Ser Asp His Arg Asp
 465                 470                 475                 480
 Glu Leu Ser Asp Trp Ser Leu Ala Pro Thr Glu Glu Glu Arg Glu Ser
                 485                 490                 495    
 Phe Leu Arg Arg Gly Asp Gly Arg Arg Arg Gly Gly Gly Gly Arg Gly
             500                 505                 510        
 Gln Gly Gly Arg Gly Arg Gly Gly Gly Phe Lys Asp Ser Val Val Gly
         515                 520                 525            
 Leu Asn Arg Gly Cys Gly Asn Lys Glu Leu Pro Val Ser Ile Ser Glu
     530                 535                 540                
 Ser Val Thr Val Glu Pro Phe Glu Asn Ile Leu Ile Gly Asn Asp Asp
 545                 550                 555                 560
 His Ser Arg Thr Asp Asn Arg Pro Arg Asn Pro Arg Glu Ala Lys Gly
                 565                 570                 575    
 Arg Thr Thr Asp Gly Ser Leu Gln Ile Arg Val Asp Cys Asn Asn Glu
             580                 585                 590        
 Arg Ser Val His Thr Lys Thr Leu Gln Asn Thr Ser Ser Glu Gly Ser
         595                 600                 605            
 Arg Leu Arg Thr Gly Lys Asp Arg Asn Gln Lys Lys Glu Lys Pro Asp
     610                 615                 620                
 Ser Val Asp Gly Gln Gln Pro Leu Val Asn Gly Val Pro
 625                 630                 635        



      <210> 277
      <211> 616
      <212> PRT
      <213> Homo sapiens


      <400> 277
 Met Ala Lys Glu Gly Arg Tyr Glu Cys Ile Cys Gly Trp Ala Phe Val
   1               5                  10                  15    
 Lys Asp Val His Glu Asp Ser Ile Thr Val Ala Phe Glu Asn Asn Trp
              20                  25                  30        
 Gln Pro Asp Arg Gln Ile Pro Phe His Asp Val Arg Phe Pro Pro Pro
          35                  40                  45            
 Val Gly Tyr Asn Lys Asp Ile Asn Glu Ser Asp Glu Val Glu Phe Tyr
      50                  55                  60                
 Val Ile Glu Tyr Ala Ala Cys Asp Ala Thr Tyr Asn Glu Ile Val Thr
  65                  70                  75                  80
 Ile Glu Arg Leu Arg Ser Val Asn Pro Asn Lys Pro Ala Thr Lys Asp
                  85                  90                  95    
 Thr Phe His Lys Ile Lys Leu Asp Val Pro Glu Asp Leu Arg Gln Met
             100                 105                 110        
 Cys Ala Lys Glu Ala Ala His Lys Asp Phe Lys Lys Ala Val Gly Ala
         115                 120                 125            
 Phe Ser Val Thr Tyr Asp Pro Glu Asn Tyr Gln Leu Val Ile Leu Ser
     130                 135                 140                
 Ile Asn Glu Val Thr Ser Lys Arg Ala His Met Leu Ile Asp Met His
 145                 150                 155                 160
 Phe Arg Ser Leu Arg Thr Lys Leu Ser Leu Ile Met Arg Asn Glu Glu
                 165                 170                 175    
 Ala Ser Lys Gln Leu Glu Ser Ser Arg Gln Leu Ala Ser Arg Phe His
             180                 185                 190        
 Glu Gln Phe Ile Val Arg Glu Asp Leu Met Gly Leu Ala Ile Gly Thr
         195                 200                 205            
 His Gly Ala Asn Ile Gln Gln Ala Arg Lys Val Pro Gly Val Thr Ala
     210                 215                 220                
 Ile Asp Leu Asp Glu Asp Thr Cys Thr Phe His Ile Tyr Gly Glu Asp
 225                 230                 235                 240
 Gln Asp Ala Val Lys Lys Ala Arg Ser Phe Leu Glu Phe Ala Glu Asp
                 245                 250                 255    
 Val Ile Gln Val Pro Arg Asn Leu Val Gly Lys Val Ile Gly Lys Asn
             260                 265                 270        
 Gly Lys Leu Ile Gln Glu Ile Val Asp Lys Ser Gly Val Val Arg Val
         275                 280                 285            
 Arg Ile Glu Ala Glu Asn Glu Lys Asn Val Pro Gln Glu Glu Glu Ile
     290                 295                 300                
 Met Pro Pro Asn Ser Leu Pro Ser Asn Asn Ser Arg Val Gly Pro Asn
 305                 310                 315                 320
 Ala Pro Glu Glu Lys Lys His Leu Asp Ile Lys Glu Asn Ser Thr His
                 325                 330                 335    
 Phe Ser Gln Pro Asn Ser Thr Lys Val Gln Arg Gly Met Val Pro Phe
             340                 345                 350        
 Val Phe Val Gly Thr Lys Asp Ser Ile Ala Asn Ala Thr Val Leu Leu
         355                 360                 365            
 Asp Tyr His Leu Asn Tyr Leu Lys Glu Val Asp Gln Leu Arg Leu Glu
     370                 375                 380                
 Arg Leu Gln Ile Asp Glu Gln Leu Arg Gln Ile Gly Ala Ser Ser Arg
 385                 390                 395                 400
 Pro Pro Pro Asn Arg Thr Asp Lys Glu Lys Ser Tyr Val Thr Asp Asp
                 405                 410                 415    
 Gly Gln Gly Met Gly Arg Gly Ser Arg Pro Tyr Arg Asn Arg Gly His
             420                 425                 430        
 Gly Arg Arg Gly Pro Gly Tyr Thr Ser Gly Thr Asn Ser Glu Ala Ser
         435                 440                 445            
 Asn Ala Ser Glu Thr Glu Ser Asp His Arg Asp Glu Leu Ser Asp Trp
     450                 455                 460                
 Ser Leu Ala Pro Thr Glu Glu Glu Arg Glu Ser Phe Leu Arg Arg Gly
 465                 470                 475                 480
 Asp Gly Arg Arg Arg Gly Gly Gly Gly Arg Gly Gln Gly Gly Arg Gly
                 485                 490                 495    
 Arg Gly Gly Gly Phe Lys Asp Ser Val Val Gly Leu Asn Arg Gly Cys
             500                 505                 510        
 Gly Asn Lys Glu Leu Pro Val Ser Ile Ser Glu Ser Val Thr Val Glu
         515                 520                 525            
 Pro Phe Glu Asn Ile Leu Ile Gly Asn Asp Asp His Ser Arg Thr Asp
     530                 535                 540                
 Asn Arg Pro Arg Asn Pro Arg Glu Ala Lys Gly Arg Thr Thr Asp Gly
 545                 550                 555                 560
 Ser Leu Gln Ile Arg Val Asp Cys Asn Asn Glu Arg Ser Val His Thr
                 565                 570                 575    
 Lys Thr Leu Gln Asn Thr Ser Ser Glu Gly Ser Arg Leu Arg Thr Gly
             580                 585                 590        
 Lys Asp Arg Asn Gln Lys Lys Glu Lys Pro Asp Ser Val Asp Gly Gln
         595                 600                 605            
 Gln Pro Leu Val Asn Gly Val Pro
     610                 615    



      <210> 278
      <211> 429
      <212> PRT
      <213> Homo sapiens


      <400> 278
 Met Ala Val Ala Val Gly Arg Pro Ser Asn Glu Glu Leu Arg Asn Leu
   1               5                  10                  15    
 Ser Leu Ser Gly His Val Gly Phe Asp Ser Leu Pro Asp Gln Leu Val
              20                  25                  30        
 Asn Lys Ser Thr Ser Gln Gly Phe Cys Phe Asn Ile Leu Cys Val Gly
          35                  40                  45            
 Glu Thr Gly Ile Gly Lys Ser Thr Leu Met Asp Thr Leu Phe Asn Thr
      50                  55                  60                
 Lys Phe Glu Ser Asp Pro Ala Thr His Asn Glu Pro Gly Val Arg Leu
  65                  70                  75                  80
 Lys Ala Arg Ser Tyr Glu Leu Gln Glu Ser Asn Val Arg Leu Lys Leu
                  85                  90                  95    
 Thr Ile Val Asp Thr Val Gly Phe Gly Asp Gln Ile Asn Lys Asp Asp
             100                 105                 110        
 Ser Tyr Lys Pro Ile Val Glu Tyr Ile Asp Ala Gln Phe Glu Ala Tyr
         115                 120                 125            
 Leu Gln Glu Glu Leu Lys Ile Lys Arg Ser Leu Phe Asn Tyr His Asp
     130                 135                 140                
 Thr Arg Ile His Ala Cys Leu Tyr Phe Ile Ala Pro Thr Gly His Ser
 145                 150                 155                 160
 Leu Lys Ser Leu Asp Leu Val Thr Met Lys Lys Leu Asp Ser Lys Val
                 165                 170                 175    
 Asn Ile Ile Pro Ile Ile Ala Lys Ala Asp Thr Ile Ala Lys Asn Glu
             180                 185                 190        
 Leu His Lys Phe Lys Ser Lys Ile Met Ser Glu Leu Val Ser Asn Gly
         195                 200                 205            
 Val Gln Ile Tyr Gln Phe Pro Thr Asp Glu Glu Thr Val Ala Glu Ile
     210                 215                 220                
 Asn Ala Thr Met Ser Val His Leu Pro Phe Ala Val Val Gly Ser Thr
 225                 230                 235                 240
 Glu Glu Val Lys Ile Gly Asn Lys Met Ala Lys Ala Arg Gln Tyr Pro
                 245                 250                 255    
 Trp Gly Val Val Gln Val Glu Asn Glu Asn His Cys Asp Phe Val Lys
             260                 265                 270        
 Leu Arg Glu Met Leu Ile Arg Val Asn Met Glu Asp Leu Arg Glu Gln
         275                 280                 285            
 Thr His Thr Arg His Tyr Glu Leu Tyr Arg Arg Cys Lys Leu Glu Glu
     290                 295                 300                
 Met Gly Phe Lys Asp Thr Asp Pro Asp Ser Lys Pro Phe Ser Leu Gln
 305                 310                 315                 320
 Glu Thr Tyr Glu Ala Lys Arg Asn Glu Phe Leu Gly Glu Leu Gln Lys
                 325                 330                 335    
 Lys Glu Glu Glu Met Arg Gln Met Phe Val Met Arg Val Lys Glu Lys
             340                 345                 350        
 Glu Ala Glu Leu Lys Glu Ala Glu Lys Glu Leu His Glu Lys Phe Asp
         355                 360                 365            
 Leu Leu Lys Arg Thr His Gln Glu Lys Lys Lys Lys Val Glu Asp Lys
     370                 375                 380                
 Lys Lys Glu Leu Glu Glu Glu Val Asn Asn Phe Gln Lys Lys Lys Ala
 385                 390                 395                 400
 Ala Ala Gln Leu Leu Gln Ser Gln Ala Gln Gln Ser Gly Ala Gln Gln
                 405                 410                 415    
 Thr Lys Lys Asp Lys Asp Lys Lys Asn Phe Phe Phe Met
             420                 425                



      <210> 279
      <211> 133
      <212> PRT
      <213> Homo sapiens


      <400> 279
 Met Lys Val Pro Gln Ser Gly Gly Asp Ser Leu Val Glu Lys Ser Gln
   1               5                  10                  15    
 Lys Ala Thr Ala Pro Asn Lys Pro Pro Ala Leu Ser Asn Thr Glu Lys
              20                  25                  30        
 Arg Asn His Ser Ala Phe Trp Gly Pro Glu Ser Gln Ile Ile Pro Val
          35                  40                  45            
 Met Pro Asp Ser Ser Ser Ser Gly Lys Asn Arg Lys Glu Glu Ser Tyr
      50                  55                  60                
 Ile Phe Glu Ser Lys Gly Asp Gly Gly Gly Gly Glu His Pro Ala Pro
  65                  70                  75                  80
 Glu Thr Gly Ala Val Leu Pro Leu Ala Leu Gly Leu Ala Ile Thr Ala
                  85                  90                  95    
 Leu Leu Leu Leu Met Val Ala Cys Arg Leu Arg Leu Val Lys Gln Lys
             100                 105                 110        
 Leu Lys Lys Ala Arg Pro Ile Thr Ser Glu Glu Ser Asp Tyr Leu Ile
         115                 120                 125            
 Asn Gly Met Tyr Leu
     130            



      <210> 280
      <211> 458
      <212> PRT
      <213> Homo sapiens


      <400> 280
 Met Glu Arg Gly Pro Gly Ala Arg Gly Arg Gly Pro Gly Cys Gly Ala
   1               5                  10                  15    
 Leu Ala Thr Ser Val Cys Pro Phe Val Ser Gly Val Ser Arg Gly Leu
              20                  25                  30        
 Leu Leu Ser Thr Gly Leu Ser Gly Pro Ser Cys Met Met Pro Pro Lys
          35                  40                  45            
 Leu Gln Gly Pro Pro Ser Pro Gln His Gln Arg Gly Ser Thr Glu Pro
      50                  55                  60                
 Leu Phe Val Val Phe Pro Leu Ser Pro Asp Ile Ala Gly Arg Pro Gly
  65                  70                  75                  80
 Gly Val Val Gly Gly Gly Pro Gly Gly Gly Pro Ala Trp Ala Ala Pro
                  85                  90                  95    
 Ala Met Asn Gly Leu Ser Leu Ser Glu Leu Cys Cys Leu Phe Cys Cys
             100                 105                 110        
 Pro Pro Cys Pro Gly Arg Ile Ala Ala Lys Leu Ala Phe Leu Pro Pro
         115                 120                 125            
 Glu Ala Thr Tyr Ser Leu Val Pro Glu Pro Glu Pro Gly Pro Gly Gly
     130                 135                 140                
 Ala Gly Ala Ala Pro Leu Gly Thr Leu Arg Ala Ser Ser Gly Ala Pro
 145                 150                 155                 160
 Gly Arg Trp Lys Leu His Leu Thr Glu Arg Ala Asp Phe Gln Tyr Ser
                 165                 170                 175    
 Gln Arg Glu Leu Asp Thr Ile Glu Val Phe Pro Thr Lys Ser Ala Arg
             180                 185                 190        
 Gly Asn Arg Val Ser Cys Met Tyr Val Arg Cys Val Pro Gly Ala Arg
         195                 200                 205            
 Gln Gly His Gln Ala Gln Gly Gly His Pro Gln Leu Ala Trp Val Gly
     210                 215                 220                
 Arg Leu Gly Asp Ser Asn Asn Pro Ala Pro Gly Gly Cys Leu Leu Gly
 225                 230                 235                 240
 Lys Ser Trp Gly Thr Gly Ala Ala Leu Ala Cys Gly Tyr Ile His Leu
                 245                 250                 255    
 Leu Ala Arg Tyr Thr Val Leu Phe Ser His Gly Asn Ala Val Asp Leu
             260                 265                 270        
 Gly Gln Met Ser Ser Phe Tyr Ile Gly Leu Gly Ser Arg Leu His Cys
         275                 280                 285            
 Asn Ile Phe Ser Tyr Asp Tyr Ser Gly Tyr Gly Ala Ser Ser Gly Arg
     290                 295                 300                
 Pro Ser Glu Arg Asn Leu Tyr Ala Asp Ile Asp Ala Ala Trp Gln Ala
 305                 310                 315                 320
 Leu Arg Thr Arg Tyr Gly Ile Ser Pro Asp Ser Ile Ile Leu Tyr Gly
                 325                 330                 335    
 Gln Ser Ile Gly Thr Val Pro Thr Val Asp Leu Ala Ser Arg Tyr Glu
             340                 345                 350        
 Cys Ala Ala Val Val Leu His Ser Pro Leu Thr Ser Gly Met Arg Val
         355                 360                 365            
 Ala Phe Pro Asp Thr Lys Lys Thr Tyr Cys Phe Asp Ala Phe Pro Asn
     370                 375                 380                
 Ile Glu Lys Val Ser Lys Ile Thr Ser Pro Val Leu Ile Ile His Gly
 385                 390                 395                 400
 Thr Glu Asp Glu Val Ile Asp Phe Ser His Gly Leu Ala Leu Tyr Glu
                 405                 410                 415    
 Arg Cys Pro Lys Ala Val Glu Pro Leu Trp Val Glu Gly Ala Gly His
             420                 425                 430        
 Asn Asp Ile Glu Leu Tyr Ser Gln Tyr Leu Glu Arg Leu Arg Arg Phe
         435                 440                 445            
 Ile Ser Gln Glu Leu Pro Ser Gln Arg Ala
     450                 455            



      <210> 281
      <211> 328
      <212> PRT
      <213> Homo sapiens


      <400> 281
 Met Ala Leu Gly Glu Gly Lys Ser His Cys Gly Glu Asp Arg Lys Glu
   1               5                  10                  15    
 His Asn Asn Ala Cys His Gln Glu Glu Glu Ala Pro Asp Val Asn Pro
              20                  25                  30        
 Leu His Gly Leu Gln Ala Ser Gly Ser Pro Gly Lys Thr Gln Arg Ile
          35                  40                  45            
 Lys Ser Gln Ala Leu Glu Gly Thr Arg Leu Tyr Ser His Ser Glu Glu
      50                  55                  60                
 Thr Arg Ser Gly Leu Ile Arg Leu Leu Arg Leu Arg Gln Arg Arg Leu
  65                  70                  75                  80
 Arg Asp Trp Gly Arg Gly Cys Trp Ser Arg Val Met Leu Gly Gly Ser
                  85                  90                  95    
 Leu Gly Ser Arg Leu Leu Arg Gly Val Gly Gly Ser His Gly Arg Phe
             100                 105                 110        
 Gly Ala Arg Gly Val Arg Glu Gly Gly Ala Ala Met Ala Ala Gly Glu
         115                 120                 125            
 Ser Met Ala Gln Arg Met Val Trp Val Asp Leu Glu Met Thr Gly Leu
     130                 135                 140                
 Asp Ile Glu Lys Asp Gln Ile Ile Glu Met Ala Cys Leu Ile Thr Asp
 145                 150                 155                 160
 Ser Asp Leu Asn Ile Leu Ala Glu Gly Pro Asn Leu Ile Ile Lys Gln
                 165                 170                 175    
 Pro Asp Glu Leu Leu Asp Ser Met Ser Asp Trp Cys Lys Glu His His
             180                 185                 190        
 Gly Lys Ser Gly Leu Thr Lys Ala Val Lys Glu Ser Thr Ile Thr Leu
         195                 200                 205            
 Gln Gln Ala Glu Tyr Glu Phe Leu Ser Phe Val Arg Gln Gln Thr Pro
     210                 215                 220                
 Pro Gly Leu Cys Pro Leu Ala Gly Asn Ser Val His Glu Asp Lys Lys
 225                 230                 235                 240
 Phe Leu Asp Lys Tyr Met Pro Gln Phe Met Lys His Leu His Tyr Arg
                 245                 250                 255    
 Ile Ile Asp Val Ser Thr Val Lys Glu Leu Cys Arg Arg Trp Tyr Pro
             260                 265                 270        
 Glu Glu Tyr Glu Phe Ala Pro Lys Lys Ala Ala Ser His Arg Ala Leu
         275                 280                 285            
 Asp Asp Ile Ser Glu Ser Ile Lys Glu Leu Gln Phe Tyr Arg Asn Asn
     290                 295                 300                
 Ile Phe Lys Lys Lys Ile Asp Glu Lys Lys Arg Lys Ile Ile Glu Asn
 305                 310                 315                 320
 Gly Glu Asn Glu Lys Thr Val Ser
                 325            



      <210> 282
      <211> 233
      <212> PRT
      <213> Homo sapiens


      <400> 282
 Met Glu Asp Leu Thr Arg Ser Asp Arg Thr Gly Ile Pro Gly Thr Thr
   1               5                  10                  15    
 Ile Ser Ser Ala Glu Leu Ser Ala Ser Pro Leu Ser Pro Ala Pro Gly
              20                  25                  30        
 Leu Pro Arg His Ser Arg Leu His Ala Leu Leu Gly Leu Ala Met Pro
          35                  40                  45            
 Val Asp Leu Ser Lys Trp Ser Gly Pro Leu Ser Leu Gln Glu Val Asp
      50                  55                  60                
 Glu Gln Pro Gln His Pro Leu His Val Thr Tyr Ala Gly Ala Ala Val
  65                  70                  75                  80
 Asp Glu Leu Gly Lys Val Leu Thr Pro Thr Gln Val Lys Asn Arg Pro
                  85                  90                  95    
 Thr Ser Ile Ser Trp Asp Gly Leu Asp Ser Gly Lys Leu Tyr Thr Leu
             100                 105                 110        
 Val Leu Thr Asp Pro Asp Ala Pro Ser Arg Lys Asp Pro Lys Tyr Arg
         115                 120                 125            
 Glu Trp His His Phe Leu Val Val Asn Met Lys Gly Asn Asp Ile Ser
     130                 135                 140                
 Ser Gly Thr Val Leu Ser Asp Tyr Val Gly Ser Gly Pro Pro Lys Gly
 145                 150                 155                 160
 Thr Gly Leu His Arg Tyr Val Trp Leu Val Tyr Glu Gln Asp Arg Pro
                 165                 170                 175    
 Leu Lys Cys Asp Glu Pro Ile Leu Ser Asn Arg Ser Gly Asp His Arg
             180                 185                 190        
 Gly Lys Phe Lys Val Ala Ser Phe Arg Lys Lys Tyr Glu Leu Arg Ala
         195                 200                 205            
 Pro Val Ala Gly Thr Cys Tyr Gln Ala Glu Trp Asp Asp Tyr Val Pro
     210                 215                 220                
 Lys Leu Tyr Glu Gln Leu Ser Gly Lys
 225                 230            



      <210> 283
      <211> 376
      <212> PRT
      <213> Homo sapiens


      <400> 283
 Met Glu Ser Tyr Asp Ile Ile Ala Asn Gln Pro Val Val Ile Asp Asn
   1               5                  10                  15    
 Gly Ser Gly Val Ile Lys Ala Gly Phe Ala Gly Asp Gln Ile Pro Lys
              20                  25                  30        
 Tyr Cys Phe Pro Asn Tyr Val Gly Arg Pro Lys His Met Arg Val Met
          35                  40                  45            
 Ala Gly Ala Leu Glu Gly Asp Leu Phe Ile Gly Pro Lys Ala Glu Glu
      50                  55                  60                
 His Arg Gly Leu Leu Thr Ile Arg Tyr Pro Met Glu His Gly Val Val
  65                  70                  75                  80
 Arg Asp Trp Asn Asp Met Glu Arg Ile Trp Gln Tyr Val Tyr Ser Lys
                  85                  90                  95    
 Asp Gln Leu Gln Thr Phe Ser Glu Glu His Pro Val Leu Leu Thr Glu
             100                 105                 110        
 Ala Pro Leu Asn Pro Ser Lys Asn Arg Glu Lys Ala Ala Glu Val Phe
         115                 120                 125            
 Phe Glu Thr Phe Asn Val Pro Ala Leu Phe Ile Ser Met Gln Ala Val
     130                 135                 140                
 Leu Ser Leu Tyr Ala Thr Gly Arg Thr Thr Gly Val Val Leu Asp Ser
 145                 150                 155                 160
 Gly Asp Gly Val Thr His Ala Val Pro Ile Tyr Glu Gly Phe Ala Met
                 165                 170                 175    
 Pro His Ser Ile Met Arg Val Asp Ile Ala Gly Arg Asp Val Ser Arg
             180                 185                 190        
 Tyr Leu Arg Leu Leu Leu Arg Lys Glu Gly Val Asp Phe His Thr Ser
         195                 200                 205            
 Ala Glu Phe Glu Val Val Arg Thr Ile Lys Glu Arg Ala Cys Tyr Leu
     210                 215                 220                
 Ser Ile Asn Pro Gln Lys Asp Glu Ala Leu Glu Thr Glu Lys Val Gln
 225                 230                 235                 240
 Tyr Thr Leu Pro Asp Gly Ser Thr Leu Asp Val Gly Pro Ala Arg Phe
                 245                 250                 255    
 Arg Ala Pro Glu Leu Leu Phe Gln Pro Asp Leu Val Gly Asp Glu Ser
             260                 265                 270        
 Glu Gly Leu His Glu Val Val Ala Phe Ala Ile His Lys Ser Asp Met
         275                 280                 285            
 Asp Leu Arg Arg Thr Leu Phe Ala Asn Ile Val Leu Ser Gly Gly Ser
     290                 295                 300                
 Thr Leu Phe Lys Gly Phe Gly Asp Arg Leu Leu Ser Glu Val Lys Lys
 305                 310                 315                 320
 Leu Ala Pro Lys Asp Ile Lys Ile Lys Ile Ser Ala Pro Gln Glu Arg
                 325                 330                 335    
 Leu Tyr Ser Thr Trp Ile Gly Gly Ser Ile Leu Ala Ser Leu Asp Thr
             340                 345                 350        
 Phe Lys Lys Met Trp Val Ser Lys Lys Glu Tyr Glu Glu Asp Gly Ser
         355                 360                 365            
 Arg Ala Ile His Arg Lys Thr Phe
     370                 375    



      <210> 284
      <211> 485
      <212> PRT
      <213> Homo sapiens


      <400> 284
 Met Thr Gln Ser Val Val Val Gln Val Gly Gln Cys Gly Asn Gln Ile
   1               5                  10                  15    
 Gly Cys Cys Phe Trp Asp Leu Ala Leu Arg Glu His Ala Ala Val Asn
              20                  25                  30        
 Gln Lys Gly Ile Tyr Asp Glu Ala Ile Ser Ser Phe Phe Arg Asn Val
          35                  40                  45            
 Asp Thr Arg Val Val Gly Asp Gly Gly Ser Ile Ser Lys Gly Lys Ile
      50                  55                  60                
 Cys Ser Leu Lys Ala Arg Ala Val Leu Ile Asp Met Glu Glu Gly Val
  65                  70                  75                  80
 Val Asn Glu Ile Leu Gln Gly Pro Leu Arg Asp Val Phe Asp Thr Lys
                  85                  90                  95    
 Gln Leu Ile Thr Asp Ile Ser Gly Ser Gly Asn Asn Trp Ala Val Gly
             100                 105                 110        
 His Lys Val Phe Gly Ser Leu Tyr Gln Asp Gln Ile Leu Glu Lys Phe
         115                 120                 125            
 Arg Lys Ser Ala Glu His Cys Asp Cys Leu Gln Cys Phe Phe Ile Ile
     130                 135                 140                
 His Ser Met Gly Gly Gly Thr Gly Ser Gly Leu Gly Thr Phe Leu Leu
 145                 150                 155                 160
 Lys Val Leu Glu Asp Glu Phe Pro Glu Val Tyr Arg Phe Val Thr Ser
                 165                 170                 175    
 Ile Tyr Pro Ser Gly Glu Asp Asp Val Ile Thr Ser Pro Tyr Asn Ser
             180                 185                 190        
 Ile Leu Ala Met Lys Glu Leu Asn Glu His Ala Asp Cys Val Leu Pro
         195                 200                 205            
 Ile Asp Asn Gln Ser Leu Phe Asp Ile Ile Ser Lys Ile Asp Leu Met
     210                 215                 220                
 Val Asn Ser Gly Lys Leu Gly Thr Thr Val Lys Pro Lys Ser Leu Val
 225                 230                 235                 240
 Thr Ser Ser Ser Gly Ala Leu Lys Lys Gln His Lys Lys Pro Phe Asp
                 245                 250                 255    
 Ala Met Asn Asn Ile Val Ala Asn Leu Leu Leu Asn Leu Thr Ser Ser
             260                 265                 270        
 Ala Arg Phe Glu Gly Ser Leu Asn Met Asp Leu Asn Glu Ile Ser Met
         275                 280                 285            
 Asn Leu Val Pro Phe Pro Gln Leu His Tyr Leu Val Ser Ser Leu Thr
     290                 295                 300                
 Pro Leu Tyr Thr Leu Thr Asp Val Asn Ile Pro Pro Arg Arg Leu Asp
 305                 310                 315                 320
 Gln Met Phe Ser Asp Ala Phe Ser Lys Asp His Gln Leu Leu Arg Ala
                 325                 330                 335    
 Asp Pro Lys His Ser Leu Tyr Leu Ala Cys Ala Leu Met Val Arg Gly
             340                 345                 350        
 Asn Val Gln Ile Ser Asp Leu Arg Arg Asn Ile Glu Arg Leu Lys Pro
         355                 360                 365            
 Ser Leu Gln Phe Val Ser Trp Asn Gln Glu Gly Trp Lys Thr Ser Leu
     370                 375                 380                
 Cys Ser Val Pro Pro Val Gly His Ser His Ser Leu Leu Ala Leu Ala
 385                 390                 395                 400
 Asn Asn Thr Cys Val Lys Pro Thr Phe Met Glu Leu Lys Glu Arg Phe
                 405                 410                 415    
 Met Arg Leu Tyr Lys Lys Lys Ala His Leu His His Tyr Leu Gln Val
             420                 425                 430        
 Glu Gly Met Glu Glu Ser Cys Phe Thr Glu Ala Val Ser Ser Leu Ser
         435                 440                 445            
 Ala Leu Ile Gln Glu Tyr Asp Gln Leu Asp Ala Thr Lys Lys His Ala
     450                 455                 460                
 Cys Ala Gly Phe Thr Gln Thr Lys His Ser Tyr Val Lys Lys Lys Pro
 465                 470                 475                 480
 Ser Lys Ile Leu Ser
                 485



      <210> 285
      <211> 572
      <212> PRT
      <213> Homo sapiens


      <400> 285
 Met Ala Ala Pro Arg Pro Ser Pro Ala Ile Ser Val Ser Val Ser Ala
   1               5                  10                  15    
 Pro Ala Phe Tyr Ala Pro Gln Lys Lys Phe Gly Pro Val Val Ala Pro
              20                  25                  30        
 Lys Pro Lys Val Asn Pro Phe Arg Pro Gly Asp Ser Glu Pro Pro Pro
          35                  40                  45            
 Ala Pro Gly Ala Gln Arg Ala Gln Met Gly Arg Val Gly Glu Ile Pro
      50                  55                  60                
 Pro Pro Pro Pro Glu Asp Phe Pro Leu Pro Pro Pro Pro Leu Ala Gly
  65                  70                  75                  80
 Asp Gly Asp Asp Ala Glu Gly Ala Leu Gly Gly Ala Phe Pro Pro Pro
                  85                  90                  95    
 Pro Pro Pro Ile Glu Glu Ser Phe Pro Pro Ala Pro Leu Glu Glu Glu
             100                 105                 110        
 Ile Phe Pro Ser Pro Pro Pro Pro Pro Glu Glu Glu Gly Gly Pro Glu
         115                 120                 125            
 Ala Pro Ile Pro Pro Pro Pro Gln Pro Arg Glu Lys Val Ser Ser Ile
     130                 135                 140                
 Asp Leu Glu Ile Asp Ser Leu Ser Ser Leu Leu Asp Asp Met Thr Lys
 145                 150                 155                 160
 Asn Asp Pro Phe Lys Ala Arg Val Ser Ser Gly Tyr Val Pro Pro Pro
                 165                 170                 175    
 Val Ala Thr Pro Phe Ser Ser Lys Ser Ser Thr Lys Pro Ala Ala Gly
             180                 185                 190        
 Gly Thr Ala Pro Leu Pro Pro Trp Lys Ser Pro Ser Ser Ser Gln Pro
         195                 200                 205            
 Leu Pro Gln Val Pro Ala Pro Ala Gln Ser Gln Thr Gln Phe His Val
     210                 215                 220                
 Gln Pro Gln Pro Gln Pro Lys Pro Gln Val Gln Leu His Val Gln Ser
 225                 230                 235                 240
 Gln Thr Gln Pro Val Ser Leu Ala Asn Thr Gln Pro Arg Gly Pro Pro
                 245                 250                 255    
 Ala Ser Ser Pro Ala Pro Ala Pro Lys Phe Ser Pro Val Thr Pro Lys
             260                 265                 270        
 Phe Thr Pro Val Ala Ser Lys Phe Ser Pro Gly Ala Pro Gly Gly Ser
         275                 280                 285            
 Gly Ser Gln Pro Asn Gln Lys Leu Gly His Pro Glu Ala Leu Ser Ala
     290                 295                 300                
 Gly Thr Gly Ser Pro Gln Pro Pro Ser Phe Thr Tyr Ala Gln Gln Arg
 305                 310                 315                 320
 Glu Lys Pro Arg Val Gln Glu Lys Gln His Pro Val Pro Pro Pro Ala
                 325                 330                 335    
 Gln Asn Gln Asn Gln Val Arg Ser Pro Gly Ala Pro Gly Pro Leu Thr
             340                 345                 350        
 Leu Lys Glu Val Glu Glu Leu Glu Gln Leu Thr Gln Gln Leu Met Gln
         355                 360                 365            
 Asp Met Glu His Pro Gln Arg Gln Asn Val Ala Val Asn Glu Leu Cys
     370                 375                 380                
 Gly Arg Cys His Gln Pro Leu Ala Arg Ala Gln Pro Ala Val Arg Ala
 385                 390                 395                 400
 Leu Gly Gln Leu Phe His Ile Ala Cys Phe Thr Cys His Gln Cys Ala
                 405                 410                 415    
 Gln Gln Leu Gln Gly Gln Gln Phe Tyr Ser Leu Glu Gly Ala Pro Tyr
             420                 425                 430        
 Cys Glu Gly Cys Tyr Thr Asp Thr Leu Glu Lys Cys Asn Thr Cys Gly
         435                 440                 445            
 Glu Pro Ile Thr Asp Arg Met Leu Arg Ala Thr Gly Lys Ala Tyr His
     450                 455                 460                
 Pro His Cys Phe Thr Cys Val Val Cys Ala Arg Pro Leu Glu Gly Thr
 465                 470                 475                 480
 Ser Phe Ile Val Asp Gln Ala Asn Arg Pro His Cys Val Pro Asp Tyr
                 485                 490                 495    
 His Lys Gln Tyr Ala Pro Arg Cys Ser Val Cys Ser Glu Pro Ile Met
             500                 505                 510        
 Pro Glu Pro Gly Arg Asp Glu Thr Val Arg Val Val Ala Leu Asp Lys
         515                 520                 525            
 Asn Phe His Met Lys Cys Tyr Lys Cys Glu Asp Cys Gly Lys Pro Leu
     530                 535                 540                
 Ser Ile Glu Ala Asp Asp Asn Gly Cys Phe Pro Leu Asp Gly His Val
 545                 550                 555                 560
 Leu Cys Arg Lys Cys His Thr Ala Arg Ala Gln Thr
                 565                 570        



      <210> 286
      <211> 307
      <212> PRT
      <213> Homo sapiens


      <400> 286
 Met Ala Ser Val Leu Ser Tyr Glu Ser Leu Val His Ala Val Ala Gly
   1               5                  10                  15    
 Ala Val Gly Ser Val Thr Ala Met Thr Val Phe Phe Pro Leu Asp Thr
              20                  25                  30        
 Ala Arg Leu Arg Leu Gln Val Asp Glu Lys Arg Lys Ser Lys Thr Thr
          35                  40                  45            
 His Met Val Leu Leu Glu Ile Ile Lys Glu Glu Gly Leu Leu Ala Pro
      50                  55                  60                
 Tyr Arg Gly Trp Phe Pro Val Ile Ser Ser Leu Cys Cys Ser Asn Phe
  65                  70                  75                  80
 Val Tyr Phe Tyr Thr Phe Asn Ser Leu Lys Ala Leu Trp Val Lys Gly
                  85                  90                  95    
 Gln His Ser Thr Thr Gly Lys Asp Leu Val Val Gly Phe Val Ala Gly
             100                 105                 110        
 Val Val Asn Val Leu Leu Thr Thr Pro Leu Trp Val Val Asn Thr Arg
         115                 120                 125            
 Leu Lys Leu Gln Gly Ala Lys Phe Arg Asn Glu Asp Ile Val Pro Thr
     130                 135                 140                
 Asn Tyr Lys Gly Ile Ile Asp Ala Phe His Gln Ile Ile Arg Asp Glu
 145                 150                 155                 160
 Gly Ile Ser Ala Leu Trp Asn Gly Thr Phe Pro Ser Leu Leu Leu Val
                 165                 170                 175    
 Phe Asn Pro Ala Ile Gln Phe Met Phe Tyr Glu Gly Leu Lys Arg Gln
             180                 185                 190        
 Leu Leu Lys Lys Arg Met Lys Leu Ser Ser Leu Asp Val Phe Ile Ile
         195                 200                 205            
 Gly Ala Val Ala Lys Ala Ile Ala Thr Thr Val Thr Tyr Pro Leu Gln
     210                 215                 220                
 Thr Val Gln Ser Ile Leu Arg Phe Gly Arg His Arg Leu Asn Pro Glu
 225                 230                 235                 240
 Asn Arg Thr Leu Gly Ser Leu Arg Asn Ile Leu Tyr Leu Leu His Gln
                 245                 250                 255    
 Arg Val Arg Arg Phe Gly Ile Met Gly Leu Tyr Lys Gly Leu Glu Ala
             260                 265                 270        
 Lys Leu Leu Gln Thr Val Leu Thr Ala Ala Leu Met Phe Leu Val Tyr
         275                 280                 285            
 Glu Lys Leu Thr Ala Ala Thr Phe Thr Val Met Gly Leu Lys Arg Ala
     290                 295                 300                
 His Gln His
 305        



      <210> 287
      <211> 938
      <212> PRT
      <213> Homo sapiens


      <400> 287
 Met Thr Ser Phe Phe Ser Glu Ser Pro Gln Pro Ile Gly Ser Leu Gly
   1               5                  10                  15    
 His Asp Ala Asp Leu Arg Arg Gln Gln Gln Asp Thr Cys Asn Ser Gly
              20                  25                  30        
 Ile Ala Asp Ile His Arg Leu Phe Asn Trp Leu Ser Glu Thr Leu Ala
          35                  40                  45            
 Asn Ala Arg His Ser Asp Ala Ser Leu Thr Asp Thr Val Asn Lys Ala
      50                  55                  60                
 Leu Gly Leu Ser Thr Asp Asp Ala Tyr Glu Glu Leu Arg Gln Lys His
  65                  70                  75                  80
 Glu Tyr Glu Leu Asn Ser Thr Pro Asp Lys Lys Asp Tyr Glu Gln Pro
                  85                  90                  95    
 Thr Cys Ala Lys Val Glu Asn Ala Gln Phe Lys Gly Thr Gln Ser Leu
             100                 105                 110        
 Leu Leu Glu Val Asp Ala Thr Ser Lys Tyr Ser Val Ala Ile Ser Thr
         115                 120                 125            
 Ser Glu Val Gly Thr Asp His Lys Leu His Leu Lys Glu Asp Pro Asn
     130                 135                 140                
 Leu Ile Ser Val Asn Asn Phe Glu Asp Cys Ser Leu Cys Pro Ser Val
 145                 150                 155                 160
 Pro Ile Glu His Gly Phe Arg Arg Gln Gln Ser Lys Ser Asn Asn Val
                 165                 170                 175    
 Glu Glu Thr Glu Ile His Trp Lys Leu Ile Pro Ile Thr Gly Gly Asn
             180                 185                 190        
 Ala Arg Ser Pro Glu Asp Gln Leu Gly Lys His Gly Glu Lys Gln Thr
         195                 200                 205            
 Pro Gly Met Lys Ser Pro Glu Glu Gln Leu Val Cys Val Pro Pro Gln
     210                 215                 220                
 Glu Ala Phe Pro Asn Asp Pro Arg Val Ile Asn Arg Gln Arg Ser Ser
 225                 230                 235                 240
 Asp Tyr Gln Phe Pro Ser Ser Pro Phe Thr Asp Thr Leu Lys Gly Thr
                 245                 250                 255    
 Thr Glu Asp Asp Val Leu Thr Gly Gln Val Glu Glu Gln Cys Val Pro
             260                 265                 270        
 Ala Ala Glu Ala Glu Pro Pro Ala Val Ser Glu Thr Thr Glu Arg Thr
         275                 280                 285            
 Val Leu Gly Glu Tyr Asn Leu Phe Ser Arg Lys Ile Glu Glu Ile Leu
     290                 295                 300                
 Lys Gln Lys Asn Val Ser Tyr Val Ser Arg Val Ser Thr Pro Ile Phe
 305                 310                 315                 320
 Ser Thr Gln Glu Lys Met Lys Arg Leu Ser Glu Phe Ile Tyr Ser Lys
                 325                 330                 335    
 Thr Ser Lys Ala Gly Val Gln Glu Phe Val Asp Gly Leu His Glu Lys
             340                 345                 350        
 Leu Asn Thr Ile Ile Ile Lys Ala Ser Ala Lys Gly Gly Asn Leu Pro
         355                 360                 365            
 Pro Val Ser Pro Asn Asp Ser Gly Ala Lys Ile Ala Ser Asn Pro Leu
     370                 375                 380                
 Glu Arg His Val Ile Pro Val Ser Ser Ser Asp Phe Asn Asn Lys His
 385                 390                 395                 400
 Leu Leu Glu Pro Leu Cys Ser Asp Pro Leu Lys Asp Thr Asn Ser Asp
                 405                 410                 415    
 Glu Gln His Ser Thr Ser Ala Leu Thr Glu Val Glu Met Asn Gln Pro
             420                 425                 430        
 Gln His Ala Thr Glu Leu Met Val Thr Ser Asp His Ile Val Pro Gly
         435                 440                 445            
 Asp Met Ala Arg Glu Pro Val Glu Glu Thr Thr Lys Ser Pro Ser Asp
     450                 455                 460                
 Val Asn Ile Ser Ala Gln Pro Ala Leu Ser Asn Phe Ile Ser Gln Leu
 465                 470                 475                 480
 Glu Pro Glu Val Phe Asn Ser Leu Val Lys Ile Met Lys Asp Val Gln
                 485                 490                 495    
 Lys Asn Thr Val Lys Phe Tyr Ile His Glu Glu Glu Glu Ser Val Leu
             500                 505                 510        
 Cys Lys Glu Ile Lys Glu Tyr Leu Ile Lys Leu Gly Asn Thr Glu Cys
         515                 520                 525            
 His Pro Glu Gln Phe Leu Glu Arg Arg Ser Lys Leu Asp Lys Leu Leu
     530                 535                 540                
 Ile Ile Ile Gln Asn Glu Asp Ile Ala Gly Phe Ile His Lys Ile Pro
 545                 550                 555                 560
 Gly Leu Val Thr Leu Lys Lys Leu Pro Cys Val Ser Phe Ala Gly Val
                 565                 570                 575    
 Asp Ser Leu Asp Asp Val Lys Asn His Thr Tyr Asn Glu Leu Phe Val
             580                 585                 590        
 Ser Gly Gly Phe Ile Val Ser Asp Glu Ser Ile Leu Asn Pro Glu Val
         595                 600                 605            
 Val Thr Val Glu Asn Leu Lys Asn Phe Leu Thr Phe Leu Glu Glu Leu
     610                 615                 620                
 Ser Thr Pro Glu Gly Lys Trp Gln Trp Lys Val His Cys Lys Phe Gln
 625                 630                 635                 640
 Lys Lys Leu Lys Glu Leu Gly Arg Leu Asn Ala Lys Ala Leu Ser Leu
                 645                 650                 655    
 Leu Thr Leu Leu Asn Val Tyr Gln Lys Lys His Leu Val Glu Ile Leu
             660                 665                 670        
 Ser Tyr His Asn Cys Asp Ser Gln Thr Arg Asn Ala Pro Glu Leu Asp
         675                 680                 685            
 Cys Leu Ile Arg Leu Gln Ala Gln Asn Ile Gln Gln Arg His Ile Val
     690                 695                 700                
 Phe Leu Thr Glu Lys Asn Ile Lys Met Leu Ser Ser Tyr Thr Asp Asn
 705                 710                 715                 720
 Gly Ile Val Val Ala Thr Ala Glu Asp Phe Met Gln Asn Phe Lys Asn
                 725                 730                 735    
 Leu Val Gly Tyr His Asn Ser Ile Thr Glu Glu Asn Leu Pro Gln Leu
             740                 745                 750        
 Gly Ala Asn Glu Asn Leu Glu Ser Gln Ser Ala Leu Leu Glu Asn Asp
         755                 760                 765            
 Glu Lys Asp Glu Glu Asp Met Ser Leu Asp Ser Gly Asp Glu Ile Ser
     770                 775                 780                
 His Ile Glu Val Cys Ser Asn Phe His Ser Glu Ile Trp Glu Lys Glu
 785                 790                 795                 800
 Thr Lys Gly Ser Arg Gly Thr Asp Gln Lys Lys Asn Thr Gln Ile Glu
                 805                 810                 815    
 Leu Gln Ser Ser Pro Asp Val Gln Asn Ser Leu Leu Glu Asp Lys Thr
             820                 825                 830        
 Tyr Leu Asp Ser Glu Glu Arg Thr Ser Ile Asp Ile Val Cys Ser Glu
         835                 840                 845            
 Gly Glu Asn Ser Asn Ser Thr Glu Gln Asp Ser Tyr Ser Asn Phe Gln
     850                 855                 860                
 Val Tyr His Ser Gln Leu Asn Met Ser His Gln Phe Ser His Phe Asn
 865                 870                 875                 880
 Val Leu Thr His Gln Thr Phe Leu Gly Thr Pro Tyr Ala Leu Ser Ser
                 885                 890                 895    
 Ser Gln Ser Gln Glu Asn Glu Asn Tyr Phe Leu Ser Ala Tyr Thr Glu
             900                 905                 910        
 Ser Leu Asp Arg Asp Lys Ser Pro Pro Pro Leu Ser Trp Gly Lys Ser
         915                 920                 925            
 Asp Ser Ser Arg Pro Tyr Ser Gln Glu Lys
     930                 935            



      <210> 288
      <211> 135
      <212> PRT
      <213> Homo sapiens


      <400> 288
 Met Ala Glu Val Gln Val Leu Val Leu Asp Gly Arg Gly His Leu Leu
   1               5                  10                  15    
 Gly Arg Leu Ala Ala Ile Val Ala Lys Gln Val Leu Leu Gly Arg Lys
              20                  25                  30        
 Val Val Val Val Arg Cys Glu Gly Ile Asn Ile Ser Gly Asn Phe Tyr
          35                  40                  45            
 Arg Asn Lys Leu Lys Tyr Leu Ala Phe Leu Arg Lys Arg Met Asn Thr
      50                  55                  60                
 Asn Pro Ser Arg Gly Pro Tyr His Phe Arg Ala Pro Ser Arg Ile Phe
  65                  70                  75                  80
 Trp Arg Thr Val Arg Gly Met Leu Pro His Lys Thr Lys Arg Gly Gln
                  85                  90                  95    
 Ala Ala Leu Asp Arg Leu Lys Val Phe Asp Gly Ile Pro Pro Pro Tyr
             100                 105                 110        
 Asp Lys Pro Leu Ser Phe Ser Asn Arg Lys Ser Gly Trp Trp Phe Leu
         115                 120                 125            
 Leu Pro Ser Arg Ser Cys Val
     130                 135



      <210> 289
      <211> 1939
      <212> PRT
      <213> Homo sapiens


      <400> 289
 Met Pro Ile Glu Gly Ile Val Thr Tyr His Gln Ser His His Ser Gly
   1               5                  10                  15    
 Gly Ile Leu Thr Tyr Asn Cys Thr Gln His Thr Gly Glu Ile Val Thr
              20                  25                  30        
 Leu Val Cys Ser Ser Cys Gln Lys Leu Ser Val Thr Leu Thr His Gly
          35                  40                  45            
 Gln Arg Leu Leu Lys Gln Leu Leu Ser Leu Lys Ser Ala Lys Ile Ala
      50                  55                  60                
 Leu Cys Glu Ser Leu Ile Ser Gly Arg Glu Arg Ala Glu Ile Val Gln
  65                  70                  75                  80
 Lys Gln Thr Gln Thr Leu Ile Met Leu Val Ala Asp Leu Gln Gln Lys
                  85                  90                  95    
 Val Tyr Ala Gln Pro Arg Gln Val Ser Thr Val Arg Val Ser Ala Leu
             100                 105                 110        
 Ile Gly Lys Glu Trp Asp Pro Ala Thr Trp Asn Gly Asp Val Trp Glu
         115                 120                 125            
 Asp Pro Asp Glu Ala Arg Gly Ser Glu Phe Val Asn Ser Asp Glu Pro
     130                 135                 140                
 Phe Leu Glu Gly Pro Glu Asp Ile Pro Leu Thr Ile Ala Leu Gln Asn
 145                 150                 155                 160
 Arg Phe Val Lys Ala Ala Pro Glu Ser Leu Lys Asn Leu Ile Ile Ala
                 165                 170                 175    
 Leu Leu Cys Met Ser Asp Leu Thr Val Gly Thr Pro Val Thr Gln Leu
             180                 185                 190        
 Gln Asn Leu Asn Thr Val Gly Ile Ile Gly Ser His Gly Tyr Leu Trp
         195                 200                 205            
 Pro Phe Met Arg Val Ile Val His Trp Gly Lys Gly Asn Asp Trp Thr
     210                 215                 220                
 Phe Trp Gly Leu Leu Asn Thr Gly Ser Glu Leu Thr Leu Ile Pro Gly
 225                 230                 235                 240
 Asp Pro Lys His His Cys Gly Pro Pro Val Lys Val Glu Ala Tyr Gly
                 245                 250                 255    
 Gly Gln Glu Thr Asp Gly Phe Trp Arg Met Thr Val Asp Tyr His Glu
             260                 265                 270        
 Val Asn Gln Val Val Thr Pro Ile Ala Ala Ala Val Pro Asp Val Val
         275                 280                 285            
 Ser Leu Leu Glu Gln Ile Thr Thr Ser Pro Asp Asn Tyr Ser Pro Phe
     290                 295                 300                
 Glu Arg Gln Leu Leu Ala Tyr Tyr Trp Ala Leu Val Lys Thr Glu Leu
 305                 310                 315                 320
 Leu Thr Met Gly Cys Gln Val Thr Met Arg Pro Glu Leu Pro Ile Met
                 325                 330                 335    
 Asn Trp Val Leu Ser Asp Pro Ser Asn His Lys Gly Leu Lys Gly Arg
             340                 345                 350        
 Gly Leu Lys His Tyr Pro Ile Arg Asp Ala Gly Leu Gly Thr Ser Asn
         355                 360                 365            
 Gln Ala Gly Ser Trp Arg Gly Gln Val Gly Phe Arg Asp Val Val Gly
     370                 375                 380                
 Pro Leu Ser Leu Ala Ala Ala Gly Gly Gln Gly Leu Val Leu Thr Ala
 385                 390                 395                 400
 Val Cys Pro Leu Leu Leu Glu Ser Gln Pro Leu Trp Pro Tyr Asp Leu
                 405                 410                 415    
 Gln Gly Ser Leu Thr Phe Arg Asp Val Ala Ile Glu Phe Ser Leu Glu
             420                 425                 430        
 Glu Trp Gln Cys Leu Asp Thr Ala Gln Gln Asn Leu Tyr Arg Asn Val
         435                 440                 445            
 Met Leu Glu Asn Tyr Arg Asn Leu Val Phe Leu Gly Ile Ala Ala Phe
     450                 455                 460                
 Lys Pro Asp Leu Ile Ile Phe Leu Glu Glu Gly Lys Glu Ser Trp Asn
 465                 470                 475                 480
 Met Lys Arg His Glu Met Val Glu Glu Ser Pro Val Ile Cys Ser His
                 485                 490                 495    
 Phe Ala Gln Asp Leu Trp Pro Glu Gln Gly Ile Glu Asp Ser Phe Gln
             500                 505                 510        
 Lys Val Ile Leu Arg Arg Tyr Glu Lys Cys Gly His Glu Asn Leu His
         515                 520                 525            
 Leu Lys Ile Gly Tyr Thr Asn Val Asp Glu Cys Lys Val His Lys Glu
     530                 535                 540                
 Gly Tyr Asn Lys Leu Asn Gln Ser Leu Thr Thr Thr Gln Ser Lys Val
 545                 550                 555                 560
 Phe Gln Arg Gly Lys Tyr Ala Asn Val Phe His Lys Cys Ser Asn Ser
                 565                 570                 575    
 Asn Arg His Lys Ile Arg His Thr Gly Lys Lys His Leu Gln Cys Lys
             580                 585                 590        
 Glu Tyr Val Arg Ser Phe Cys Met Leu Ser His Leu Ser Gln His Lys
         595                 600                 605            
 Arg Ile Tyr Thr Arg Glu Asn Ser Tyr Lys Cys Glu Glu Gly Gly Lys
     610                 615                 620                
 Ala Phe Asn Trp Ser Ser Thr Leu Thr Tyr Tyr Lys Ser Ala His Thr
 625                 630                 635                 640
 Gly Glu Lys Pro Tyr Arg Cys Lys Glu Cys Gly Lys Ala Phe Ser Lys
                 645                 650                 655    
 Phe Ser Ile Leu Thr Lys His Lys Val Ile His Thr Gly Glu Lys Ser
             660                 665                 670        
 Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Asn Gln Ser Ala Ile Leu
         675                 680                 685            
 Thr Lys His Lys Ile Ile His Thr Gly Glu Lys Pro Asn Lys Cys Glu
     690                 695                 700                
 Glu Cys Gly Lys Ala Phe Ser Lys Val Ser Thr Leu Thr Thr His Lys
 705                 710                 715                 720
 Ala Ile His Ala Gly Glu Lys Pro Tyr Lys Cys Lys Glu Cys Gly Lys
                 725                 730                 735    
 Ala Phe Ser Lys Val Ser Thr Leu Ile Thr His Lys Ala Ile His Ala
             740                 745                 750        
 Gly Glu Lys Pro Tyr Lys Cys Lys Glu Cys Gly Lys Ala Phe Ser Lys
         755                 760                 765            
 Phe Ser Ile Leu Thr Lys His Lys Val Ile His Thr Gly Glu Lys Pro
     770                 775                 780                
 Tyr Lys Cys Glu Glu Cys Gly Lys Ala Tyr Lys Trp Pro Ser Thr Leu
 785                 790                 795                 800
 Ser Tyr His Lys Lys Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu
                 805                 810                 815    
 Glu Cys Gly Lys Gly Phe Ser Met Phe Ser Ile Leu Thr Lys His Glu
             820                 825                 830        
 Val Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys
         835                 840                 845            
 Ala Phe Asn Trp Ser Ser Asn Leu Met Glu His Lys Lys Ile His Thr
     850                 855                 860                
 Gly Glu Thr Pro Tyr Lys Cys Glu Glu Cys Gly Lys Gly Phe Ser Met
 865                 870                 875                 880
 Phe Ser Ile Leu Thr Lys His Lys Val Ile His Asn Gly Glu Lys Pro
                 885                 890                 895    
 Tyr Lys Cys Glu Glu Cys Asp Lys Ala Thr His Ala Gly Glu Lys Pro
             900                 905                 910        
 Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Asn Trp Ser Ser Asn Leu
         915                 920                 925            
 Met Glu His Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu
     930                 935                 940                
 Glu Cys Gly Lys Ser Phe Ser Thr Phe Ser Ile Leu Thr Lys His Lys
 945                 950                 955                 960
 Val Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys
                 965                 970                 975    
 Ala Tyr Lys Trp Ser Ser Thr Leu Ser Tyr His Lys Lys Ile His Thr
             980                 985                 990        
 Val Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Asn Gln
         995                1000                1005            
 Ser Ala Ile Leu Ile Lys His Lys Arg Ile His Thr Gly Glu Lys Pro
    1010                1015                1020                
 Tyr Lys Cys Glu Glu Cys Gly Lys Thr Phe Ser Lys Val Ser Thr Leu
1025                1030                1035                1040
 Thr Thr His Lys Ala Ile His Ala Gly Glu Lys Pro Tyr Lys Cys Lys
                1045                1050                1055    
 Glu Cys Gly Lys Thr Phe Ile Lys Val Ser Thr Leu Thr Thr His Lys
            1060                1065                1070        
 Ala Ile His Ala Gly Glu Lys Pro Tyr Lys Cys Lys Glu Cys Gly Lys
        1075                1080                1085            
 Ala Phe Ser Lys Phe Ser Ile Leu Thr Lys His Lys Val Ile His Thr
    1090                1095                1100                
 Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Asn Trp
1105                1110                1115                1120
 Ser Ser Asn Leu Met Glu His Lys Arg Ile His Thr Gly Glu Lys Pro
                1125                1130                1135    
 Tyr Lys Cys Glu Glu Cys Gly Lys Ser Phe Ser Thr Phe Ser Val Leu
            1140                1145                1150        
 Thr Lys His Lys Val Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu
        1155                1160                1165            
 Glu Cys Gly Lys Ala Tyr Lys Trp Ser Ser Thr Leu Ser Tyr His Lys
    1170                1175                1180                
 Lys Ile His Thr Val Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys
1185                1190                1195                1200
 Ala Phe Asn Arg Ser Ala Ile Leu Ile Lys His Lys Arg Ile His Thr
                1205                1210                1215    
 Asp Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys Thr Phe Ser Lys
            1220                1225                1230        
 Val Ser Thr Leu Thr Thr His Lys Ala Ile His Ala Gly Glu Lys Pro
        1235                1240                1245            
 Tyr Lys Cys Lys Glu Cys Gly Lys Ala Phe Ser Lys Phe Ser Ile Leu
    1250                1255                1260                
 Thr Lys His Lys Val Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu
1265                1270                1275                1280
 Glu Cys Gly Lys Ala Tyr Lys Trp Pro Ser Thr Leu Ser Tyr His Lys
                1285                1290                1295    
 Lys Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys
            1300                1305                1310        
 Gly Phe Ser Met Phe Ser Ile Leu Thr Lys His Glu Val Ile His Thr
        1315                1320                1325            
 Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Ser Trp
    1330                1335                1340                
 Leu Ser Val Phe Ser Lys His Lys Lys Thr His Ala Gly Glu Lys Phe
1345                1350                1355                1360
 Tyr Lys Cys Glu Ala Cys Gly Lys Ala Tyr Lys Ser Ser Ser Thr Leu
                1365                1370                1375    
 Ser Tyr His Lys Lys Ile His Thr Glu Glu Lys Pro Tyr Lys Tyr Glu
            1380                1385                1390        
 Glu Cys Gly Lys Gly Phe Ser Thr Phe Ser Ile Leu Thr Lys His Lys
        1395                1400                1405            
 Val Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys
    1410                1415                1420                
 Ala Phe Asn Trp Ser Ser Asn Leu Met Glu His Lys Lys Ile His Thr
1425                1430                1435                1440
 Gly Glu Thr Pro Tyr Lys Cys Glu Glu Cys Asp Lys Ala Phe Ser Trp
                1445                1450                1455    
 Pro Ser Ser Leu Thr Glu His Lys Ala Thr His Ala Gly Glu Lys Pro
            1460                1465                1470        
 Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Ser Trp Pro Ser Arg Leu
        1475                1480                1485            
 Thr Glu His Lys Ala Thr His Ala Gly Glu Glu Pro Tyr Lys Cys Glu
    1490                1495                1500                
 Glu Cys Gly Lys Ala Phe Asn Trp Ser Ser Asn Leu Met Glu His Lys
1505                1510                1515                1520
 Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys
                1525                1530                1535    
 Ser Phe Ser Thr Phe Ser Ile Leu Thr Lys His Lys Val Ile His Thr
            1540                1545                1550        
 Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys Ala Tyr Lys Trp
        1555                1560                1565            
 Ser Ser Thr Leu Ser Tyr His Lys Lys Ile His Thr Val Glu Lys Pro
    1570                1575                1580                
 Tyr Lys Cys Glu Glu Cys Gly Lys Gly Phe Val Met Phe Ser Ile Leu
1585                1590                1595                1600
 Ala Lys His Lys Val Ile His Thr Gly Glu Lys Leu Tyr Lys Cys Glu
                1605                1610                1615    
 Glu Cys Gly Lys Ala Tyr Lys Trp Pro Ser Thr Leu Arg Tyr His Lys
            1620                1625                1630        
 Lys Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys
        1635                1640                1645            
 Ala Phe Ser Thr Phe Ser Ile Leu Thr Lys His Lys Val Ile His Thr
    1650                1655                1660                
 Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Ser Cys
1665                1670                1675                1680
 Tyr His Lys Lys Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Glu
                1685                1690                1695    
 Cys Gly Glu Ala Phe Asn Trp Ser Ser Asn Leu Met Glu His Lys Arg
            1700                1705                1710        
 Ile His Thr Gly Glu Thr Pro Tyr Lys Cys Glu Glu Cys Gly Lys Gly
        1715                1720                1725            
 Phe Ser Met Phe Ser Ile Leu Thr Lys His Lys Val Ile His Thr Gly
    1730                1735                1740                
 Glu Lys Pro Tyr Lys Cys Lys Glu Cys Gly Lys Ala Tyr Lys Trp Ser
1745                1750                1755                1760
 Ser Thr Leu Ser Tyr His Arg Lys Phe Ile Leu Glu Arg Asn Pro Thr
                1765                1770                1775    
 Asn Val Lys Lys Val Ala Lys Pro Ser Ala Gly Ser Gln Ser Leu Asn
            1780                1785                1790        
 Ser Tyr Trp Arg Lys Asn Pro Thr Asn Met Lys Asn Val Ala Lys Leu
        1795                1800                1805            
 Leu Ile Asn Ser Gln Arg Leu Leu Asn Ile Arg Glu Phe Val Gln Glu
    1810                1815                1820                
 Gly Asn Pro Thr Asn Leu Lys Asn Val Ala Ser Leu Leu Ala Ile Pro
1825                1830                1835                1840
 Gln Ser Leu Leu Asn Ile His Val Ile His Thr Gly Gly Asn Ser Tyr
                1845                1850                1855    
 Asn Cys Val Glu Cys Cys Asn Ala Leu Asn Gln Ser Leu Arg Leu Thr
            1860                1865                1870        
 Thr Tyr Lys Thr Thr His Thr Gly Glu Lys Pro Cys Met Cys Glu Glu
        1875                1880                1885            
 Cys Gly Lys Ala Ser Asn Arg Ser Ser Ile Leu Lys Arg His Lys Leu
    1890                1895                1900                
 Ile His Thr Gln Glu Arg Leu Tyr Lys Pro Glu Arg Cys Asp Asn Ala
1905                1910                1915                1920
 Phe Gly Asn Thr Ser Asp Phe Ser Glu Tyr Lys Arg Asn Arg Thr Asp
                1925                1930                1935    
 Glu Lys Ser
            



      <210> 290
      <211> 123
      <212> PRT
      <213> Homo sapiens


      <400> 290
 Met Ser Glu Lys Ser Gly Gln Ser Thr Lys Ala Lys Asp Gly Lys Lys
   1               5                  10                  15    
 Tyr Ala Thr Leu Ser Leu Phe Asn Thr Tyr Lys Gly Lys Ser Leu Glu
              20                  25                  30        
 Thr Gln Lys Thr Thr Ala Arg His Gly Leu Gln Ser Leu Gly Lys Val
          35                  40                  45            
 Gly Ile Ser Arg Arg Met Pro Pro Pro Ala Asn Leu Pro Ser Leu Lys
      50                  55                  60                
 Ala Glu Asn Lys Gly Asn Asp Pro Asn Val Asn Ile Val Pro Lys Asp
  65                  70                  75                  80
 Gly Thr Gly Trp Ala Ser Lys Gln Glu Gln His Glu Glu Glu Lys Asn
                  85                  90                  95    
 Thr Arg Ser Ala Thr Ser Thr Ala Lys Thr Cys Gly Cys Ser Ser Pro
             100                 105                 110        
 Arg Ser Ser Thr Cys Ser Gln Ile Met Gly Gln
         115                 120            



      <210> 291
      <211> 69
      <212> PRT
      <213> Homo sapiens


      <400> 291
 Met Ala Trp Ala Pro Leu Leu Leu Thr Leu Leu Ala His Cys Thr Gly
   1               5                  10                  15    
 Ser Trp Ala Ser Phe Met Leu Thr Gln Pro His Ser Met Ser Glu Ser
              20                  25                  30        
 Pro Gly Lys Thr Ala Thr Ile Ser Cys Thr Arg Ser Ser Gly Asn Ile
          35                  40                  45            
 Ala Ser Tyr Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Gln Phe Pro
      50                  55                  60                
 His Tyr Cys Asp Leu
  65                



      <210> 292
      <211> 221
      <212> PRT
      <213> Homo sapiens


      <400> 292
 Met Val Phe Arg Arg Phe Val Glu Val Gly Arg Val Ala Tyr Val Ser
   1               5                  10                  15    
 Phe Gly Pro His Ala Gly Lys Leu Val Ala Ile Val Asp Val Ile Asp
              20                  25                  30        
 Gln Asn Arg Ala Leu Val Asp Gly Pro Cys Thr Gln Val Arg Arg Gln
          35                  40                  45            
 Ala Met Pro Phe Lys Cys Met Gln Leu Thr Asp Phe Ile Leu Lys Phe
      50                  55                  60                
 Pro His Ser Ala His Gln Lys Tyr Val Arg Gln Ala Trp Gln Lys Ala
  65                  70                  75                  80
 Asp Ile Asn Thr Lys Trp Ala Ala Thr Arg Trp Ala Lys Lys Ile Glu
                  85                  90                  95    
 Ala Arg Glu Arg Lys Ala Lys Met Thr Asp Phe Asp Arg Phe Lys Val
             100                 105                 110        
 Met Lys Ala Lys Lys Met Arg Asn Arg Ile Ile Lys Asn Glu Val Lys
         115                 120                 125            
 Lys Leu Gln Lys Ala Ala Leu Leu Lys Ala Ser Pro Lys Lys Ala Pro
     130                 135                 140                
 Gly Thr Lys Gly Thr Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala
 145                 150                 155                 160
 Ala Ala Ala Ala Ala Lys Val Pro Ala Lys Lys Ile Thr Ala Ala Ser
                 165                 170                 175    
 Lys Lys Ala Pro Ala Gln Lys Val Pro Ala Gln Lys Ala Thr Gly Gln
             180                 185                 190        
 Lys Ala Ala Pro Ala Pro Lys Ala Gln Lys Gly Gln Lys Ala Pro Ala
         195                 200                 205            
 Gln Lys Ala Pro Ala Pro Lys Ala Ser Gly Lys Lys Ala
     210                 215                 220    



      <210> 293
      <211> 488
      <212> PRT
      <213> Homo sapiens


      <400> 293
 Met Pro Lys Val Lys Ala Leu Gln Cys Ala Leu Ala Leu Glu Ile Ser
   1               5                  10                  15    
 Ser Val Thr Cys Pro Gly Val Val Leu Lys Asp Lys Glu Asp Ile Tyr
              20                  25                  30        
 Leu Ser Ile Cys Val Phe Gly Gln Tyr Lys Lys Thr Gln Cys Val Pro
          35                  40                  45            
 Ala Thr Phe Pro Leu Val Phe Asn Ala Arg Met Val Phe Glu Lys Val
      50                  55                  60                
 Phe Pro Asp Ala Val Asp Pro Gly Asp Val Val Thr Gln Leu Glu Tyr
  65                  70                  75                  80
 Asp Thr Ala Val Phe Glu Leu Ile Gln Leu Val Pro Pro Val Gly Glu
                  85                  90                  95    
 Thr Leu Ser Thr Tyr Asp Glu Asn Thr Arg Asp Phe Met Phe Pro Gly
             100                 105                 110        
 Pro Asn Gln Met Ser Gly His His Asp Ser Asn Arg Gln Val Thr Met
         115                 120                 125            
 Arg Arg Ile Ser Gly Leu Arg Gly Asn Ala Pro Arg Leu Glu Phe Ser
     130                 135                 140                
 Thr Thr Ser Val Ile Thr Glu Cys Leu Ile Ser Ser Arg Lys Cys His
 145                 150                 155                 160
 Thr Gln Asp Lys Phe Ile Tyr His Leu Ala Pro Val Glu Lys Ser His
                 165                 170                 175    
 Gly Arg Leu Gln Asn Arg Thr Ser Arg Ser Gln Lys Lys Lys Ser Lys
             180                 185                 190        
 Ser Pro Glu Arg Ser Lys Tyr Cys Ile Asn Ala Lys Asn Tyr Glu Gln
         195                 200                 205            
 Pro Thr Ile Ser Ser Lys Ser His Ser Pro Ser Pro Tyr Thr Lys Arg
     210                 215                 220                
 Arg Met Cys Glu Leu Ser Glu Asp Thr Arg Arg Arg Leu Ala His Leu
 225                 230                 235                 240
 Asn Leu Gly Pro Tyr Glu Phe Lys Lys Glu Thr Asp Lys Pro Pro Phe
                 245                 250                 255    
 Val Ile Arg His Val Asp Pro Pro Ser Pro Arg Ala Asp Thr Leu Leu
             260                 265                 270        
 Gly Ser Ser Gly Arg Asp Cys Glu Arg Asp Gly Trp Ser Arg Val His
         275                 280                 285            
 Asn Asp His Ser His Leu Gly Cys Cys Arg Pro Lys Asp Tyr Lys Val
     290                 295                 300                
 Ile Arg Thr Pro His Gly Arg Asp Phe Asp Asp Ser Leu Glu Lys Cys
 305                 310                 315                 320
 Glu Glu Tyr Leu Ser Pro Arg Ser Cys Ser Lys Pro Arg His Ser Ala
                 325                 330                 335    
 Arg Thr Leu Leu Val His Ser Ala Pro Ser Thr Met Pro Lys His Ser
             340                 345                 350        
 Pro Ser Pro Val Leu Asn Arg Ala Ser Leu Arg Glu Arg Phe His Ser
         355                 360                 365            
 Asp Trp Cys Ser Pro Ser Asn Cys Asp Glu Ile His Asp Arg Val Lys
     370                 375                 380                
 Asn Val Leu Lys Ser His Gln Ala His Gln Arg His Leu Tyr Asp Glu
 385                 390                 395                 400
 Arg Asp Leu Glu Lys Asp Asp Glu Leu Glu Leu Lys Arg Ser Leu Leu
                 405                 410                 415    
 Cys Arg Asp Ser Ala Tyr Asp Ser Asp Pro Glu Tyr Ser Ser Cys Gln
             420                 425                 430        
 Gln Pro Arg Gly Thr Phe His Leu Asp Asp Gly Glu Tyr Trp Ser Asn
         435                 440                 445            
 Arg Ala Ala Ser Tyr Lys Gly Lys Ser His Arg Pro Ile Phe Glu Asn
     450                 455                 460                
 Ser Met Asp Lys Met Tyr Arg Asn Leu Tyr Lys Lys Ala Cys Ser Ser
 465                 470                 475                 480
 Ala Ser His Thr Gln Glu Ser Phe
                 485            



      <210> 294
      <211> 482
      <212> PRT
      <213> Homo sapiens


      <400> 294
 Met Leu Asp Lys Glu Glu Arg Glu Gln Gly Trp Val Leu Ile Asp Leu
   1               5                  10                  15    
 Ser Glu Glu Tyr Thr Arg Met Gly Leu Pro Asn His Tyr Trp Gln Leu
              20                  25                  30        
 Ser Asp Val Asn Arg Asp Tyr Arg Phe Ser Ile Leu Leu Thr Lys Thr
          35                  40                  45            
 Val Glu Val Ser Lys Gly Gly Ile Ile Thr Glu Asp Phe Ile Arg Gly
      50                  55                  60                
 Leu Asp Phe Ser Cys Gly Phe Ser Thr Pro Thr Thr Pro Ser Ser Arg
  65                  70                  75                  80
 Val Ile Lys Val Cys Asp Ser Tyr Pro Thr Glu Leu Tyr Val Pro Lys
                  85                  90                  95    
 Ser Ala Thr Ala His Ile Ile Val Gly Ser Ser Lys Phe Arg Ser Arg
             100                 105                 110        
 Arg Arg Phe Pro Val Leu Ser Tyr Tyr Tyr Lys Asp Asn His Ala Ser
         115                 120                 125            
 Ile Cys Arg Ser Ser Gln Pro Leu Ser Gly Phe Ser Ala Arg Cys Leu
     130                 135                 140                
 Glu Asp Glu Gln Met Leu Gln Ala Ile Arg Lys Ala Asn Pro Gly Ser
 145                 150                 155                 160
 Asp Phe Val Tyr Val Val Asp Thr Arg Pro Lys Leu Asn Ala Met Ala
                 165                 170                 175    
 Asn Arg Ala Ala Gly Lys Gly Tyr Glu Asn Glu Asp Asn Tyr Ser Asn
             180                 185                 190        
 Ile Lys Phe Gln Phe Ile Gly Ile Glu Asn Ile His Val Met Arg Asn
         195                 200                 205            
 Ser Leu Gln Lys Met Leu Glu Val Cys Glu Leu Lys Ser Pro Ser Met
     210                 215                 220                
 Ser Asp Phe Leu Trp Gly Leu Glu Asn Ser Gly Trp Leu Arg His Ile
 225                 230                 235                 240
 Lys Ala Ile Met Asp Ala Gly Ile Phe Ile Ala Lys Ala Val Ser Glu
                 245                 250                 255    
 Glu Gly Ala Ser Val Leu Val His Cys Ser Asp Gly Trp Asp Arg Thr
             260                 265                 270        
 Ala Gln Val Cys Ser Val Ala Ser Leu Leu Leu Asp Pro His Tyr Arg
         275                 280                 285            
 Thr Leu Lys Gly Phe Met Val Leu Ile Glu Lys Asp Trp Ile Ser Phe
     290                 295                 300                
 Gly His Lys Phe Asn His Arg Tyr Gly Asn Leu Asp Gly Asp Pro Lys
 305                 310                 315                 320
 Glu Ile Ser Pro Val Ile Asp Gln Phe Ile Glu Cys Val Trp Gln Leu
                 325                 330                 335    
 Met Glu Gln Phe Pro Cys Ala Phe Glu Phe Asn Glu Arg Phe Leu Ile
             340                 345                 350        
 His Ile Gln His His Ile Tyr Ser Cys Gln Phe Gly Asn Phe Leu Cys
         355                 360                 365            
 Asn Ser Gln Lys Glu Arg Arg Glu Leu Lys Ile Gln Glu Arg Thr Tyr
     370                 375                 380                
 Ser Leu Trp Ala His Leu Trp Lys Asn Arg Ala Asp Asn Leu Asn Leu
 385                 390                 395                 400
 Leu Phe Arg Ala Asp His Ser Gln Thr Gln Gly Thr Phe His Leu Pro
                 405                 410                 415    
 Thr Thr Pro Cys Asn Phe Met Tyr Lys Phe Trp Ser Gly Met Tyr Asn
             420                 425                 430        
 Arg Phe Glu Lys Gly Met Gln Pro Arg Gln Ser Val Thr Asp Tyr Leu
         435                 440                 445            
 Met Ala Val Lys Glu Glu Thr Gln Gln Leu Glu Glu Glu Leu Glu Ala
     450                 455                 460                
 Leu Glu Glu Val Arg His Thr Cys Phe Val Asn Leu Phe Ser Val Leu
 465                 470                 475                 480
 Ile Ser
        



      <210> 295
      <211> 593
      <212> PRT
      <213> Homo sapiens


      <400> 295
 Met Thr Pro Asp Leu Leu Asn Phe Lys Lys Gly Trp Met Ser Ile Leu
   1               5                  10                  15    
 Asp Glu Pro Gly Glu Pro Pro Ser Pro Ser Leu Thr Thr Thr Ser Thr
              20                  25                  30        
 Ser Gln Trp Lys Lys His Trp Phe Val Leu Thr Asp Ser Ser Leu Lys
          35                  40                  45            
 Tyr Tyr Arg Asp Ser Thr Ala Glu Glu Ala Asp Glu Leu Asp Gly Glu
      50                  55                  60                
 Ile Asp Leu Arg Ser Cys Thr Asp Val Thr Glu Tyr Ala Val Gln Arg
  65                  70                  75                  80
 Asn Tyr Gly Phe Gln Ile His Thr Lys Asp Ala Val Tyr Thr Leu Ser
                  85                  90                  95    
 Ala Met Thr Ser Gly Ile Arg Arg Asn Trp Ile Glu Ala Leu Arg Lys
             100                 105                 110        
 Thr Val Arg Pro Thr Ser Ala Pro Asp Val Thr Lys Leu Ser Asp Ser
         115                 120                 125            
 Asn Lys Glu Asn Ala Leu His Ser Tyr Ser Thr Gln Lys Gly Pro Leu
     130                 135                 140                
 Lys Ala Gly Glu Gln Arg Ala Gly Ser Glu Val Ile Ser Arg Gly Gly
 145                 150                 155                 160
 Pro Arg Lys Ala Asp Gly Gln Arg Gln Ala Leu Asp Tyr Val Glu Leu
                 165                 170                 175    
 Ser Pro Leu Thr Gln Ala Ser Pro Gln Arg Ala Arg Thr Pro Ala Arg
             180                 185                 190        
 Thr Pro Asp Arg Leu Ala Lys Gln Glu Glu Leu Glu Arg Asp Leu Ala
         195                 200                 205            
 Gln Arg Ser Glu Glu Arg Arg Lys Trp Phe Glu Ala Thr Asp Ser Arg
     210                 215                 220                
 Thr Pro Glu Val Pro Ala Gly Glu Gly Pro Arg Arg Gly Leu Gly Ala
 225                 230                 235                 240
 Pro Leu Thr Glu Asp Gln Gln Asn Arg Leu Ser Glu Glu Ile Glu Lys
                 245                 250                 255    
 Lys Trp Gln Glu Leu Glu Lys Leu Pro Leu Arg Glu Asn Lys Arg Val
             260                 265                 270        
 Pro Leu Thr Ala Leu Leu Asn Gln Ser Arg Gly Glu Arg Arg Gly Pro
         275                 280                 285            
 Pro Ser Asp Gly His Glu Ala Leu Glu Lys Glu Val Gln Ala Leu Arg
     290                 295                 300                
 Ala Gln Leu Glu Ala Trp Arg Leu Gln Gly Glu Ala Pro Gln Ser Ala
 305                 310                 315                 320
 Leu Arg Ser Gln Glu Asp Gly His Ile Pro Pro Gly Tyr Ile Ser Gln
                 325                 330                 335    
 Glu Ala Cys Glu Arg Ser Leu Ala Glu Met Glu Ser Ser His Gln Gln
             340                 345                 350        
 Val Met Glu Glu Leu Gln Arg His His Glu Arg Glu Leu Gln Arg Leu
         355                 360                 365            
 Gln Gln Glu Lys Glu Trp Leu Leu Ala Glu Glu Thr Ala Ala Thr Ala
     370                 375                 380                
 Ser Ala Ile Glu Ala Met Lys Lys Ala Tyr Gln Glu Glu Leu Ser Arg
 385                 390                 395                 400
 Glu Leu Ser Lys Thr Arg Ser Leu Gln Gln Gly Pro Asp Gly Leu Arg
                 405                 410                 415    
 Lys Gln His Gln Ser Asp Val Glu Ala Leu Lys Arg Glu Leu Gln Val
             420                 425                 430        
 Leu Ser Glu Gln Tyr Ser Gln Lys Cys Leu Glu Ile Gly Ala Leu Met
         435                 440                 445            
 Arg Gln Ala Glu Glu Arg Glu His Thr Leu Arg Arg Cys Gln Gln Glu
     450                 455                 460                
 Gly Gln Glu Leu Leu Arg His Asn Gln Glu Leu His Gly Arg Leu Ser
 465                 470                 475                 480
 Glu Glu Ile Asp Gln Leu Arg Gly Phe Ile Ala Ser Gln Gly Met Gly
                 485                 490                 495    
 Asn Gly Cys Gly Arg Ser Asn Glu Arg Ser Ser Cys Glu Leu Glu Val
             500                 505                 510        
 Leu Leu Arg Val Lys Glu Asn Glu Leu Gln Tyr Leu Lys Lys Glu Val
         515                 520                 525            
 Gln Cys Leu Arg Asp Glu Leu Gln Met Met Gln Lys Asp Lys Arg Phe
     530                 535                 540                
 Thr Ser Gly Lys Tyr Gln Asp Val Tyr Val Glu Leu Ser His Ile Lys
 545                 550                 555                 560
 Thr Arg Ser Glu Arg Glu Ile Glu Gln Leu Lys Glu His Leu Arg Leu
                 565                 570                 575    
 Ala Met Ala Ala Leu Gln Glu Lys Glu Ser Met Arg Asn Ser Leu Ala
             580                 585                 590        
 Glu
    



      <210> 296
      <211> 758
      <212> PRT
      <213> Homo sapiens


      <400> 296
 Met Gly Gly Cys Thr Val Lys Pro Gln Leu Leu Leu Leu Ala Leu Val
   1               5                  10                  15    
 Leu His Pro Trp Asn Pro Cys Leu Gly Ala Asp Ser Glu Lys Pro Ser
              20                  25                  30        
 Ser Ile Pro Thr Asp Lys Leu Leu Val Ile Thr Val Ala Thr Lys Glu
          35                  40                  45            
 Ser Asp Gly Phe His Arg Phe Met Gln Ser Ala Lys Tyr Phe Asn Tyr
      50                  55                  60                
 Thr Val Lys Val Leu Gly Gln Gly Glu Glu Trp Arg Gly Gly Asp Gly
  65                  70                  75                  80
 Ile Asn Ser Ile Gly Gly Gly Gln Lys Val Arg Leu Met Lys Glu Val
                  85                  90                  95    
 Met Glu His Tyr Ala Asp Gln Asp Asp Leu Val Val Met Phe Thr Glu
             100                 105                 110        
 Cys Phe Asp Val Ile Phe Ala Gly Gly Pro Glu Glu Val Leu Lys Lys
         115                 120                 125            
 Phe Gln Lys Ala Asn His Lys Val Val Phe Ala Ala Asp Gly Ile Leu
     130                 135                 140                
 Trp Pro Asp Lys Arg Leu Ala Asp Lys Tyr Pro Val Val His Ile Gly
 145                 150                 155                 160
 Lys Arg Tyr Leu Asn Ser Gly Gly Phe Ile Gly Tyr Ala Pro Tyr Val
                 165                 170                 175    
 Asn Arg Ile Val Gln Gln Trp Asn Leu Gln Asp Asn Asp Asp Asp Gln
             180                 185                 190        
 Leu Phe Tyr Thr Lys Val Tyr Ile Asp Pro Leu Lys Arg Glu Ala Ile
         195                 200                 205            
 Asn Ile Thr Leu Asp His Lys Cys Lys Ile Phe Gln Thr Leu Asn Gly
     210                 215                 220                
 Ala Val Asp Glu Val Val Leu Lys Phe Glu Asn Gly Lys Ala Arg Ala
 225                 230                 235                 240
 Lys Asn Thr Phe Tyr Glu Thr Leu Pro Val Ala Ile Asn Gly Asn Gly
                 245                 250                 255    
 Pro Thr Lys Ile Leu Leu Asn Tyr Phe Gly Asn Tyr Val Pro Asn Ser
             260                 265                 270        
 Trp Thr Gln Asp Asn Gly Cys Thr Leu Cys Glu Phe Asp Thr Val Asp
         275                 280                 285            
 Leu Ser Ala Val Asp Val His Pro Asn Val Ser Ile Gly Val Phe Ile
     290                 295                 300                
 Glu Gln Pro Thr Pro Phe Leu Pro Arg Phe Leu Asp Ile Leu Leu Thr
 305                 310                 315                 320
 Leu Asp Tyr Pro Lys Glu Ala Leu Lys Leu Phe Ile His Asn Lys Glu
                 325                 330                 335    
 Val Tyr His Glu Lys Asp Ile Lys Val Phe Phe Asp Lys Ala Lys His
             340                 345                 350        
 Glu Ile Lys Thr Ile Lys Ile Val Gly Pro Glu Glu Asn Leu Ser Gln
         355                 360                 365            
 Ala Glu Ala Arg Asn Met Gly Met Asp Phe Cys Arg Gln Asp Glu Lys
     370                 375                 380                
 Cys Asp Tyr Tyr Phe Ser Val Asp Ala Asp Val Val Leu Thr Asn Pro
 385                 390                 395                 400
 Arg Thr Leu Lys Ile Leu Ile Glu Gln Asn Arg Lys Ile Ile Ala Pro
                 405                 410                 415    
 Leu Val Thr Arg His Gly Lys Leu Trp Ser Asn Phe Trp Gly Ala Leu
             420                 425                 430        
 Ser Pro Asp Gly Tyr Tyr Ala Arg Ser Glu Asp Tyr Val Asp Ile Val
         435                 440                 445            
 Gln Gly Asn Arg Val Gly Val Trp Asn Val Pro Tyr Met Ala Asn Val
     450                 455                 460                
 Tyr Leu Ile Lys Gly Lys Thr Leu Arg Ser Glu Met Asn Glu Arg Asn
 465                 470                 475                 480
 Tyr Phe Val Arg Asp Lys Leu Asp Pro Asp Met Ala Leu Cys Arg Asn
                 485                 490                 495    
 Ala Arg Glu Met Thr Leu Gln Arg Glu Lys Asp Ser Pro Thr Pro Glu
             500                 505                 510        
 Thr Phe Gln Met Leu Ser Pro Pro Lys Gly Val Phe Met Tyr Ile Ser
         515                 520                 525            
 Asn Arg His Glu Phe Gly Arg Leu Leu Ser Thr Ala Asn Tyr Asn Thr
     530                 535                 540                
 Ser His Tyr Asn Asn Asp Leu Trp Gln Ile Phe Glu Asn Pro Val Asp
 545                 550                 555                 560
 Trp Lys Glu Lys Tyr Ile Asn Arg Asp Tyr Ser Lys Ile Phe Thr Glu
                 565                 570                 575    
 Asn Ile Val Glu Gln Pro Cys Pro Asp Val Phe Trp Phe Pro Ile Phe
             580                 585                 590        
 Ser Glu Lys Ala Cys Asp Glu Leu Val Glu Glu Met Glu His Tyr Gly
         595                 600                 605            
 Lys Trp Ser Gly Gly Lys His His Asp Ser Arg Ile Ser Gly Gly Tyr
     610                 615                 620                
 Glu Asn Val Pro Thr Asp Asp Ile His Met Lys Gln Val Asp Leu Glu
 625                 630                 635                 640
 Asn Val Trp Leu His Phe Ile Arg Glu Phe Ile Ala Pro Val Thr Leu
                 645                 650                 655    
 Lys Val Phe Ala Gly Tyr Tyr Thr Lys Gly Phe Ala Leu Leu Asn Phe
             660                 665                 670        
 Val Val Lys Tyr Ser Pro Glu Arg Gln Arg Ser Leu Arg Pro His His
         675                 680                 685            
 Asp Ala Ser Thr Phe Thr Ile Asn Ile Ala Leu Asn Asn Val Gly Glu
     690                 695                 700                
 Asp Phe Gln Gly Gly Gly Cys Lys Phe Leu Arg Tyr Asn Cys Ser Ile
 705                 710                 715                 720
 Glu Ser Pro Arg Lys Gly Trp Ser Phe Met His Pro Gly Arg Leu Thr
                 725                 730                 735    
 His Leu His Glu Gly Leu Pro Val Lys Asn Gly Thr Arg Tyr Ile Ala
             740                 745                 750        
 Val Ser Phe Ile Asp Pro
         755            



      <210> 297
      <211> 491
      <212> PRT
      <213> Homo sapiens


      <400> 297
 Met Ser Gly Thr Lys Pro Asp Ile Leu Trp Ala Pro His His Val Asp
   1               5                  10                  15    
 Arg Phe Val Val Cys Asp Ser Glu Leu Ser Leu Tyr His Val Glu Ser
              20                  25                  30        
 Thr Val Asn Ser Glu Leu Lys Ala Gly Ser Leu Arg Leu Ser Glu Asp
          35                  40                  45            
 Ser Ala Ala Thr Leu Leu Ser Ile Asn Ser Asp Thr Pro Tyr Met Lys
      50                  55                  60                
 Cys Val Ala Trp Tyr Leu Asn Tyr Asp Pro Glu Cys Leu Leu Ala Val
  65                  70                  75                  80
 Gly Gln Ala Asn Gly Arg Val Val Leu Thr Ser Leu Gly Gln Asp His
                  85                  90                  95    
 Asn Ser Lys Phe Lys Asp Leu Ile Gly Lys Glu Phe Val Pro Lys His
             100                 105                 110        
 Ala Arg Gln Cys Asn Thr Leu Ala Trp Asn Pro Leu Asp Ser Asn Trp
         115                 120                 125            
 Leu Ala Ala Gly Leu Asp Lys His Arg Ala Asp Phe Ser Val Leu Ile
     130                 135                 140                
 Trp Asp Ile Cys Ser Lys Tyr Thr Pro Asp Ile Val Pro Met Glu Lys
 145                 150                 155                 160
 Val Lys Leu Ser Ala Gly Glu Thr Glu Thr Thr Leu Leu Val Thr Lys
                 165                 170                 175    
 Pro Leu Tyr Glu Leu Gly Gln Asn Asp Ala Cys Leu Ser Leu Cys Trp
             180                 185                 190        
 Leu Pro Arg Asp Gln Lys Leu Leu Leu Ala Gly Met His Arg Asn Leu
         195                 200                 205            
 Ala Ile Phe Asp Leu Arg Asn Thr Ser Gln Lys Met Phe Val Asn Thr
     210                 215                 220                
 Lys Ala Val Gln Gly Val Thr Val Asp Pro Tyr Phe His Asp Arg Val
 225                 230                 235                 240
 Ala Ser Phe Tyr Glu Gly Gln Val Ala Ile Trp Asp Leu Arg Lys Phe
                 245                 250                 255    
 Glu Lys Pro Val Leu Thr Leu Thr Glu Gln Pro Lys Pro Leu Thr Lys
             260                 265                 270        
 Val Ala Trp Cys Pro Thr Arg Thr Gly Leu Leu Ala Thr Leu Thr Arg
         275                 280                 285            
 Asp Ser Asn Ile Ile Arg Leu Tyr Asp Met Gln His Thr Pro Thr Pro
     290                 295                 300                
 Ile Gly Asp Glu Thr Glu Pro Thr Ile Ile Glu Arg Ser Val Gln Pro
 305                 310                 315                 320
 Cys Asp Asn Tyr Ile Ala Ser Phe Ala Trp His Pro Thr Ser Gln Asn
                 325                 330                 335    
 Arg Met Ile Val Val Thr Pro Asn Arg Thr Met Ser Asp Phe Thr Val
             340                 345                 350        
 Phe Glu Arg Ile Ser Leu Ala Trp Ser Pro Ile Thr Ser Leu Met Trp
         355                 360                 365            
 Ala Cys Gly Arg His Leu Tyr Glu Cys Thr Glu Glu Glu Asn Asp Asn
     370                 375                 380                
 Ser Leu Glu Lys Asp Ile Ala Thr Lys Met Arg Leu Arg Ala Leu Ser
 385                 390                 395                 400
 Arg Tyr Gly Leu Asp Thr Glu Gln Val Trp Arg Asn His Ile Leu Ala
                 405                 410                 415    
 Gly Gly Thr Lys Ser Asp Glu Lys Val Asp Leu Ser Lys Asp Lys Lys
             420                 425                 430        
 Leu Ala Gln Phe Asn Asn Trp Phe Thr Trp Cys His Asn Cys Arg His
         435                 440                 445            
 Gly Gly His Ala Gly His Met Leu Ser Trp Phe Arg Asp His Ala Glu
     450                 455                 460                
 Cys Pro Val Ser Ala Cys Thr Cys Lys Cys Met Gln Leu Asp Thr Thr
 465                 470                 475                 480
 Gly Asn Leu Val Pro Ala Glu Thr Val Gln Pro
                 485                 490    



      <210> 298
      <211> 223
      <212> PRT
      <213> Homo sapiens


      <400> 298
 Met Tyr Ser Ser Gly Trp Pro Ala Gly Ala Ala Glu Pro Arg His Gly
   1               5                  10                  15    
 Arg Gly Arg Glu Leu Ala Gln Ala Leu Gly Cys Met His Gly Ala Pro
              20                  25                  30        
 Ser Gln Leu Ala Ser Leu Ser Leu Ala His Cys Ser Ser Leu Lys Ser
          35                  40                  45            
 Arg Pro Glu Leu Glu His Gln Ala Ser Gly Thr Lys Asp Ala Cys Pro
      50                  55                  60                
 Glu Pro Gln Gly Pro Ser Leu Leu Thr Leu Arg Ala Leu Gln Glu Leu
  65                  70                  75                  80
 Asp Leu Thr Ala Cys Ser Lys Leu Thr Asp Ala Ser Leu Ala Lys Val
                  85                  90                  95    
 Leu Gln Phe Leu Gln Leu Arg Gln Leu Ser Leu Ser Leu Leu Pro Glu
             100                 105                 110        
 Leu Thr Asp Asn Gly Leu Val Ala Val Ala Arg Gly Cys Pro Ser Leu
         115                 120                 125            
 Glu His Leu Ala Leu Ser His Cys Ser Arg Leu Ser Asp Lys Gly Trp
     130                 135                 140                
 Ala Gln Ala Ala Ser Ser Trp Pro Arg Leu Gln His Leu Asn Leu Ser
 145                 150                 155                 160
 Ser Cys Ser Gln Leu Ile Glu Gln Thr Leu Asp Ala Ile Gly Gln Ala
                 165                 170                 175    
 Cys Arg Gln Leu Arg Val Leu Asp Val Ala Thr Cys Pro Gly Ile Asn
             180                 185                 190        
 Met Ala Ala Val Arg Arg Phe Gln Ala Gln Leu Pro Gln Val Ser Cys
         195                 200                 205            
 Val Gln Ser Arg Phe Val Gly Gly Ala Asp Leu Thr Leu Thr Leu
     210                 215                 220            



      <210> 299
      <211> 151
      <212> PRT
      <213> Homo sapiens


      <400> 299
 Met Cys Asp Phe Thr Glu Asp Gln Thr Ala Glu Phe Lys Glu Ala Phe
   1               5                  10                  15    
 Gln Leu Phe Asp Arg Thr Gly Asp Gly Lys Ile Leu Tyr Ser Gln Cys
              20                  25                  30        
 Gly Asp Val Met Arg Ala Leu Gly Gln Asn Pro Thr Asn Ala Glu Val
          35                  40                  45            
 Leu Lys Val Leu Gly Asn Pro Lys Ser Asp Glu Met Asn Val Lys Val
      50                  55                  60                
 Leu Asp Phe Glu His Phe Leu Pro Met Leu Gln Thr Val Ala Lys Asn
  65                  70                  75                  80
 Lys Asp Gln Gly Thr Tyr Glu Asp Tyr Val Glu Gly Leu Arg Val Phe
                  85                  90                  95    
 Asp Lys Glu Gly Asn Gly Thr Val Met Gly Ala Glu Ile Arg His Val
             100                 105                 110        
 Leu Val Thr Leu Gly Glu Lys Met Thr Glu Glu Glu Val Glu Met Leu
         115                 120                 125            
 Val Ala Gly His Glu Asp Ser Asn Gly Cys Ile Asn Tyr Glu Glu Leu
     130                 135                 140                
 Val Arg Met Val Leu Asn Gly
 145                 150    



      <210> 300
      <211> 227
      <212> PRT
      <213> Homo sapiens


      <400> 300
 Met Glu Gly His Arg Cys Gly Ala Gly Thr Cys Pro Val Leu Pro Thr
   1               5                  10                  15    
 Ser Pro Pro Pro Ser Pro His Leu Arg Leu Pro Thr Glu Leu Ser Val
              20                  25                  30        
 Ala Gln Cys Thr Gln Arg Pro Val Asp Ile Val Phe Leu Leu Asp Gly
          35                  40                  45            
 Ser Glu Arg Leu Gly Glu Gln Asn Phe His Lys Ala Arg Arg Phe Val
      50                  55                  60                
 Glu Gln Val Ala Arg Arg Leu Thr Leu Ala Arg Arg Asp Asp Asp Pro
  65                  70                  75                  80
 Leu Asn Ala Arg Val Ala Leu Leu Gln Phe Gly Gly Pro Gly Glu Gln
                  85                  90                  95    
 Gln Val Ala Phe Pro Leu Ser His Asn Leu Thr Ala Ile His Glu Ala
             100                 105                 110        
 Leu Glu Thr Thr Gln Tyr Leu Asn Ser Phe Ser His Val Gly Ala Gly
         115                 120                 125            
 Val Val His Ala Ile Asn Ala Ile Val Arg Ser Pro Arg Gly Gly Ala
     130                 135                 140                
 Arg Arg His Ala Glu Leu Ser Phe Val Phe Leu Thr Asp Gly Val Thr
 145                 150                 155                 160
 Gly Asn Asp Ser Leu His Glu Ser Ala His Ser Met Arg Lys Gln Asn
                 165                 170                 175    
 Val Val Pro Thr Val Leu Ala Leu Gly Ser Asp Val Asp Met Asp Val
             180                 185                 190        
 Leu Thr Thr Leu Ser Leu Gly Asp Arg Ala Ala Val Phe His Glu Lys
         195                 200                 205            
 Asp Tyr Asp Ser Leu Ala Gln Pro Gly Phe Phe Asp Arg Phe Ile Arg
     210                 215                 220                
 Trp Ile Cys
 225        



      <210> 301
      <211> 184
      <212> PRT
      <213> Homo sapiens


      <400> 301
 Met Val Arg Tyr Ser Leu Asp Pro Glu Asn Pro Thr Lys Ser Cys Lys
   1               5                  10                  15    
 Ser Arg Gly Ser Asn Leu Arg Val His Phe Lys Asn Thr Arg Glu Thr
              20                  25                  30        
 Ala Gln Ala Ile Lys Gly Met His Ile Arg Lys Ala Thr Lys Tyr Leu
          35                  40                  45            
 Lys Asp Val Thr Leu Gln Lys Gln Cys Val Pro Phe Arg Arg Tyr Asn
      50                  55                  60                
 Gly Gly Val Gly Arg Cys Ala Gln Ala Lys Gln Trp Gly Trp Thr Gln
  65                  70                  75                  80
 Gly Arg Trp Pro Lys Lys Ser Ala Glu Phe Leu Leu His Met Leu Lys
                  85                  90                  95    
 Asn Ala Glu Ser Asn Ala Glu Leu Lys Gly Leu Asp Val Asp Ser Leu
             100                 105                 110        
 Val Ile Glu His Ile Gln Val Asn Lys Ala Pro Lys Met Arg Arg Arg
         115                 120                 125            
 Thr Tyr Arg Ala His Gly Arg Ile Asn Pro Tyr Met Ser Ser Pro Cys
     130                 135                 140                
 His Ile Glu Met Ile Leu Thr Glu Lys Glu Gln Ile Val Pro Lys Pro
 145                 150                 155                 160
 Glu Glu Glu Val Ala Gln Lys Lys Lys Ile Ser Gln Lys Lys Leu Lys
                 165                 170                 175    
 Lys Gln Lys Leu Met Ala Arg Glu
             180                



      <210> 302
      <211> 376
      <212> PRT
      <213> Homo sapiens


      <400> 302
 Met Asn Tyr Glu Phe Glu Arg Glu Ile Gly Phe Ile Asn Ser Gln Pro
   1               5                  10                  15    
 Ser Leu Ala Glu Cys Leu Thr Ser Phe Pro Pro Val Ala Asp Thr Phe
              20                  25                  30        
 Gln Ser Ser Ser Ile Lys Thr Ser Thr Leu Ser His Ser Thr Leu Ile
          35                  40                  45            
 Pro Pro Pro Phe Glu Gln Thr Ile Pro Ser Leu Asn Pro Gly Ser His
      50                  55                  60                
 Pro Arg His Gly Ala Gly Gly Arg Pro Lys Pro Ser Pro Ala Gly Ser
  65                  70                  75                  80
 Arg Gly Ser Pro Val Pro Ala Gly Ala Leu Gln Pro Pro Glu Tyr Pro
                  85                  90                  95    
 Trp Met Lys Glu Lys Lys Ala Ala Lys Lys Thr Ala Leu Leu Pro Ala
             100                 105                 110        
 Ala Ala Ala Ala Ala Thr Ala Ala Ala Thr Gly Pro Ala Cys Leu Ser
         115                 120                 125            
 His Lys Glu Ser Leu Glu Ile Ala Asp Gly Ser Gly Gly Gly Ser Arg
     130                 135                 140                
 Arg Leu Arg Thr Ala Tyr Thr Asn Thr Gln Leu Leu Glu Leu Glu Lys
 145                 150                 155                 160
 Glu Phe His Phe Asn Lys Tyr Leu Cys Arg Pro Arg Arg Val Glu Ile
                 165                 170                 175    
 Ala Ala Leu Leu Asp Leu Thr Glu Arg Gln Val Lys Val Trp Phe Gln
             180                 185                 190        
 Asn Arg Arg Met Lys His Lys Arg Gln Thr Gln Cys Lys Glu Asn Gln
         195                 200                 205            
 Asn Ser Glu Gly Lys Cys Lys Ser Leu Glu Asp Ser Glu Lys Val Glu
     210                 215                 220                
 Glu Asp Glu Glu Glu Lys Thr Leu Phe Glu Gln Ala Leu Ser Val Ser
 225                 230                 235                 240
 Gly Ala Leu Leu Glu Arg Glu Gly Tyr Thr Phe Gln Gln Asn Ala Leu
                 245                 250                 255    
 Ser Gln Gln Gln Ala Pro Asn Gly His Asn Gly Asp Ser Gln Ser Phe
             260                 265                 270        
 Pro Val Ser Pro Leu Thr Ser Asn Glu Lys Asn Leu Lys His Phe Gln
         275                 280                 285            
 His Gln Ser Pro Thr Val Pro Asn Cys Leu Ser Thr Met Gly Gln Asn
     290                 295                 300                
 Cys Gly Ala Gly Leu Asn Asn Asp Ser Pro Glu Ala Leu Glu Val Pro
 305                 310                 315                 320
 Ser Leu Gln Asp Phe Ser Val Phe Ser Thr Asp Ser Cys Leu Gln Leu
                 325                 330                 335    
 Ser Asp Ala Val Ser Pro Ser Leu Pro Gly Ser Leu Asp Ser Pro Val
             340                 345                 350        
 Asp Ile Ser Ala Asp Ser Leu Asp Phe Phe Thr Asp Thr Leu Thr Thr
         355                 360                 365            
 Ile Asp Leu Gln His Leu Asn Tyr
     370                 375    



      <210> 303
      <211> 147
      <212> PRT
      <213> Homo sapiens


      <400> 303
 Met Ala Pro Tyr Thr Arg Asp Gly Asn Cys Pro Ser Tyr Val Lys Arg
   1               5                  10                  15    
 Arg Trp Gly Lys Arg Ala Thr Leu Ala Lys Leu Leu Thr Cys Ala Ser
              20                  25                  30        
 Ala Cys Phe Cys Gly Glu Tyr Leu Gln His Thr Arg Gly Gln Lys Thr
          35                  40                  45            
 Gln Ala Ala Ser Arg Glu Gly Lys Trp Val Leu Glu Pro Arg Val Ser
      50                  55                  60                
 Ile Gln Phe Leu Asp Val Asp Ser Thr Ala Ser Phe Val Tyr Ser Gly
  65                  70                  75                  80
 Asp Arg Val Ser Leu Cys His Pro Gly Trp Ser Lys Val Ile Gln Ser
                  85                  90                  95    
 Gln Leu Arg Lys His Arg Thr Leu Gly Leu Lys Gln Ser Ser Cys Leu
             100                 105                 110        
 Ser Leu Pro Asn Ser Trp Asp Tyr Lys His Glu Ser Leu Cys Leu Ala
         115                 120                 125            
 Asn Leu Leu Tyr Leu Leu Ser Phe Ile Leu His Pro Trp Ile Thr Arg
     130                 135                 140                
 Ser Ile Lys
 145        



      <210> 304
      <211> 88
      <212> PRT
      <213> Homo sapiens


      <400> 304
 Met Ala Ser Ser Asp Val Lys Pro Thr Ser Val Ser His Ala Lys Lys
   1               5                  10                  15    
 Trp Ser Glu Glu Ile Glu Asn Leu Tyr Arg Phe Gln Gln Ala Gly Tyr
              20                  25                  30        
 Arg Asp Glu Thr Glu Tyr Arg Gln Val Lys Gln Val Ser Met Val Asp
          35                  40                  45            
 Arg Trp Pro Glu Thr Gly Tyr Val Lys Lys Leu Gln Arg Arg Asp Asn
      50                  55                  60                
 Thr Phe Tyr Tyr Tyr Asn Lys Gln Arg Glu Cys Asp Asp Lys Glu Val
  65                  70                  75                  80
 His Lys Val Lys Ile Tyr Ala Tyr
                  85            



      <210> 305
      <211> 237
      <212> PRT
      <213> Homo sapiens


      <400> 305
 Met Ala Ala Ser Ala Ala Glu Thr Arg Val Phe Leu Glu Val Arg Gly
   1               5                  10                  15    
 Gln Leu Gln Ser Ala Leu Leu Ile Leu Gly Glu Pro Lys Glu Gly Gly
              20                  25                  30        
 Met Pro Met Asn Ile Ser Ile Met Pro Ser Ser Leu Gln Met Lys Thr
          35                  40                  45            
 Pro Glu Gly Cys Thr Glu Ile Gln Leu Pro Ala Glu Val Arg Leu Val
      50                  55                  60                
 Pro Ser Ser Cys Arg Gly Leu Gln Phe Val Val Gly Asp Gly Leu His
  65                  70                  75                  80
 Leu Arg Leu Gln Thr Gln Ala Lys Leu Gly Thr Lys Leu Ile Ser Met
                  85                  90                  95    
 Phe Asn Gln Ser Ser Gln Thr Gln Glu Cys Cys Thr Phe Tyr Cys Gln
             100                 105                 110        
 Ser Cys Gly Glu Val Ile Ile Lys Asp Arg Lys Leu Leu Arg Val Leu
         115                 120                 125            
 Pro Leu Pro Ser Glu Asn Trp Gly Ala Leu Val Gly Glu Trp Cys Cys
     130                 135                 140                
 His Pro Asp Pro Phe Ala Asn Lys Ser Leu His Pro Gln Glu Asn Asp
 145                 150                 155                 160
 Cys Phe Ile Gly Asp Ser Phe Phe Leu Val Asn Leu Arg Thr Ser Leu
                 165                 170                 175    
 Trp Gln Gln Arg Pro Glu Leu Ser Pro Val Glu Met Cys Cys Val Ser
             180                 185                 190        
 Ser Asp Asn His Cys Lys Leu Glu Pro Lys Ala Asn Thr Lys Val Ile
         195                 200                 205            
 Cys Lys Arg Cys Lys Val Met Leu Gly Glu Thr Val Ser Ser Gly Lys
     210                 215                 220                
 Asn Phe Ile Thr Arg Ser Gln Asn Asp Trp Leu Leu Ala
 225                 230                 235        



      <210> 306
      <211> 167
      <212> PRT
      <213> Homo sapiens


      <400> 306
 Met Thr Glu Thr Arg Glu Pro Ala Glu Thr Gly Gly Tyr Ala Ser Leu
   1               5                  10                  15    
 Glu Glu Asp Asp Glu Asp Leu Ser Pro Gly Pro Glu His Ser Ser Asp
              20                  25                  30        
 Ser Glu Tyr Thr Leu Ser Glu Pro Asp Ser Glu Glu Glu Glu Asp Glu
          35                  40                  45            
 Glu Glu Glu Glu Glu Glu Thr Thr Asp Asp Pro Glu Tyr Asp Pro Gly
      50                  55                  60                
 Tyr Lys Val Lys Gln Arg Leu Gly Gly Gly Arg Gly Gly Pro Ser Arg
  65                  70                  75                  80
 Arg Ala Pro Arg Ala Ala Gln Pro Pro Ala Gln Pro Cys Gln Leu Cys
                  85                  90                  95    
 Gly Arg Ser Pro Leu Gly Glu Ala Pro Pro Gly Thr Pro Arg Cys Thr
             100                 105                 110        
 Gly Thr Ser Cys Cys Met Pro Gly Val Arg Cys Arg Gln Ser Pro His
         115                 120                 125            
 Thr Gly Ser Leu Ala Glu Gly Val Gly Trp Glu Glu Gly Ala Glu Glu
     130                 135                 140                
 Ile Gly Val Val Thr Val Val Met Gly Asp Gly Val Leu Pro Val Cys
 145                 150                 155                 160
 Val Val Leu Glu Val Asp Val
                 165        



      <210> 307
      <211> 781
      <212> PRT
      <213> Homo sapiens


      <400> 307
 Met Thr Asp Thr Arg Arg Arg Val Lys Val Tyr Thr Leu Asn Glu Asp
   1               5                  10                  15    
 Arg Gln Trp Asp Asp Arg Gly Thr Gly His Val Ser Ser Gly Tyr Val
              20                  25                  30        
 Glu Arg Leu Lys Gly Met Ser Leu Leu Val Arg Ala Glu Ser Asp Gly
          35                  40                  45            
 Ser Leu Leu Leu Glu Ser Lys Ile Asn Pro Asn Thr Ala Tyr Gln Lys
      50                  55                  60                
 Gln Gln Asp Thr Leu Ile Val Trp Ser Glu Ala Glu Asn Tyr Asp Leu
  65                  70                  75                  80
 Ala Leu Ser Phe Gln Glu Lys Ala Gly Cys Asp Glu Ile Trp Glu Lys
                  85                  90                  95    
 Ile Cys Gln Val Gln Gly Lys Asp Pro Ser Val Asp Ile Thr Gln Asp
             100                 105                 110        
 Leu Val Asp Glu Ser Glu Glu Glu Arg Phe Asp Asp Met Ser Ser Pro
         115                 120                 125            
 Gly Leu Glu Leu Pro Ser Cys Glu Leu Ser Arg Leu Glu Glu Ile Ala
     130                 135                 140                
 Glu Leu Val Ala Ser Ser Leu Pro Ser Pro Leu Arg Arg Glu Lys Leu
 145                 150                 155                 160
 Ala Leu Ala Leu Glu Asn Glu Gly Tyr Ile Lys Lys Leu Leu Glu Leu
                 165                 170                 175    
 Phe His Val Cys Glu Asp Leu Glu Asn Ile Glu Gly Leu His His Leu
             180                 185                 190        
 Tyr Glu Ile Ile Lys Gly Ile Phe Leu Leu Asn Arg Thr Ala Leu Phe
         195                 200                 205            
 Glu Val Met Phe Ser Glu Glu Cys Ile Met Asp Val Ile Gly Cys Leu
     210                 215                 220                
 Glu Tyr Asp Pro Ala Leu Ser Gln Pro Arg Lys His Arg Glu Phe Leu
 225                 230                 235                 240
 Thr Lys Thr Ala Lys Phe Lys Glu Val Ile Pro Ile Ser Asp Pro Glu
                 245                 250                 255    
 Leu Lys Gln Lys Ile His Gln Thr Tyr Arg Val Gln Tyr Ile Gln Asp
             260                 265                 270        
 Met Val Leu Pro Thr Pro Ser Val Phe Glu Glu Asn Met Leu Ser Thr
         275                 280                 285            
 Leu His Ser Phe Ile Phe Phe Asn Lys Val Glu Ile Val Gly Met Leu
     290                 295                 300                
 Gln Glu Asp Glu Lys Phe Leu Thr Asp Leu Phe Ala Gln Leu Thr Asp
 305                 310                 315                 320
 Glu Ala Thr Asp Glu Glu Lys Arg Gln Glu Leu Gly Met Asp Asp Thr
                 325                 330                 335    
 Gln Val Arg Ser Ala Ala Thr Asp Ile Phe Ser Tyr Leu Val Glu Tyr
             340                 345                 350        
 Asn Pro Ser Met Val Arg Glu Phe Val Met Gln Glu Ala Gln Gln Asn
         355                 360                 365            
 Asp Asp Asp Ile Leu Leu Ile Asn Leu Ile Ile Glu His Met Ile Cys
     370                 375                 380                
 Asp Thr Asp Pro Glu Leu Gly Gly Ala Val Gln Leu Met Gly Leu Leu
 385                 390                 395                 400
 Arg Thr Leu Val Asp Pro Glu Asn Met Leu Ala Thr Ala Asn Lys Thr
                 405                 410                 415    
 Glu Lys Thr Glu Phe Leu Gly Phe Phe Tyr Lys His Cys Met His Val
             420                 425                 430        
 Leu Thr Ala Pro Leu Leu Ala Asn Thr Thr Glu Asp Lys Pro Ser Lys
         435                 440                 445            
 Asp Asp Phe Gln Thr Ala Gln Leu Leu Ala Leu Val Leu Glu Leu Leu
     450                 455                 460                
 Thr Phe Cys Val Glu His His Thr Tyr His Ile Lys Asn Tyr Ile Ile
 465                 470                 475                 480
 Asn Lys Asp Ile Leu Arg Arg Val Leu Val Leu Met Ala Ser Lys His
                 485                 490                 495    
 Ala Phe Leu Ala Leu Cys Ala Leu Arg Phe Lys Arg Lys Ile Ile Gly
             500                 505                 510        
 Leu Lys Asp Glu Phe Tyr Asn Arg Tyr Ile Met Lys Ser Phe Leu Phe
         515                 520                 525            
 Glu Pro Val Val Lys Ala Phe Leu Asn Asn Gly Ser Arg Tyr Asn Leu
     530                 535                 540                
 Met Asn Ser Ala Ile Ile Glu Met Phe Glu Phe Ile Arg Val Glu Asp
 545                 550                 555                 560
 Ile Lys Ser Leu Thr Ala His Val Ile Glu Asn Tyr Trp Lys Ala Leu
                 565                 570                 575    
 Glu Asp Val Asp Tyr Val Gln Thr Phe Lys Gly Leu Lys Leu Arg Phe
             580                 585                 590        
 Glu Gln Gln Arg Glu Arg Gln Asp Asn Pro Lys Leu Asp Ser Met Arg
         595                 600                 605            
 Ser Ile Leu Arg Asn His Arg Tyr Arg Arg Asp Ala Arg Thr Leu Glu
     610                 615                 620                
 Asp Glu Glu Glu Met Trp Phe Asn Thr Asp Glu Asp Asp Met Glu Asp
 625                 630                 635                 640
 Gly Glu Ala Val Val Ser Pro Ser Asp Lys Thr Lys Asn Asp Asp Asp
                 645                 650                 655    
 Ile Met Asp Pro Ile Ser Lys Phe Met Glu Arg Lys Lys Leu Lys Glu
             660                 665                 670        
 Ser Glu Glu Lys Glu Val Leu Leu Lys Thr Asn Leu Ser Gly Arg Gln
         675                 680                 685            
 Ser Pro Ser Phe Lys Leu Ser Leu Ser Ser Gly Thr Lys Thr Asn Leu
     690                 695                 700                
 Thr Ser Gln Ser Ser Thr Thr Asn Leu Pro Gly Ser Pro Gly Ser Pro
 705                 710                 715                 720
 Gly Ser Pro Gly Ser Pro Gly Ser Pro Gly Ser Val Pro Lys Asn Thr
                 725                 730                 735    
 Ser Gln Thr Ala Ala Ile Thr Thr Lys Gly Gly Leu Val Gly Leu Val
             740                 745                 750        
 Asp Tyr Pro Asp Asp Asp Glu Asp Asp Asp Glu Asp Glu Asp Lys Glu
         755                 760                 765            
 Asp Thr Leu Pro Leu Ser Lys Lys Ala Lys Phe Asp Ser
     770                 775                 780    



      <210> 308
      <211> 97
      <212> PRT
      <213> Homo sapiens


      <400> 308
 Met Ser Ser Ala Pro Glu Pro Pro Thr Phe Lys Lys Glu Pro Pro Lys
   1               5                  10                  15    
 Glu Lys Glu Phe Gln Ser Pro Gly Leu Arg Gly Val Arg Thr Thr Thr
              20                  25                  30        
 Leu Phe Arg Ala Val Asn Pro Glu Leu Phe Ile Lys Pro Asn Lys Pro
          35                  40                  45            
 Val Met Ala Phe Gly Leu Val Thr Leu Ser Leu Cys Val Ala Tyr Ile
      50                  55                  60                
 Gly Tyr Leu His Ala Ile Gln Glu Asn Lys Lys Asp Leu Tyr Glu Ala
  65                  70                  75                  80
 Ile Asp Ser Glu Gly His Ser Tyr Met Arg Arg Lys Thr Ser Lys Trp
                  85                  90                  95    
 Asp
    



      <210> 309
      <211> 278
      <212> PRT
      <213> Homo sapiens


      <400> 309
 Met Ala Ala Leu Phe Leu Lys Arg Leu Thr Leu Gln Thr Val Lys Ser
   1               5                  10                  15    
 Glu Asn Ser Cys Ile Arg Cys Phe Gly Lys His Ile Leu Gln Lys Thr
              20                  25                  30        
 Ala Pro Ala Gln Leu Ser Pro Ile Ala Ser Ala Pro Arg Leu Ser Phe
          35                  40                  45            
 Leu Ile His Ala Lys Ala Phe Ser Thr Ala Glu Asp Thr Gln Asn Glu
      50                  55                  60                
 Gly Lys Lys Thr Lys Lys Asn Lys Thr Ala Phe Ser Asn Val Gly Arg
  65                  70                  75                  80
 Lys Ile Ser Gln Arg Val Ile His Leu Phe Asp Glu Lys Gly Asn Asp
                  85                  90                  95    
 Leu Gly Asn Met His Arg Ala Asn Val Ile Arg Leu Met Asp Glu Arg
             100                 105                 110        
 Asp Leu Arg Leu Val Gln Arg Asn Thr Ser Thr Glu Pro Ala Glu Tyr
         115                 120                 125            
 Gln Leu Met Thr Gly Leu Gln Ile Leu Gln Glu Arg Gln Arg Leu Arg
     130                 135                 140                
 Glu Met Glu Lys Ala Asn Pro Lys Thr Gly Pro Thr Leu Arg Lys Glu
 145                 150                 155                 160
 Leu Ile Leu Ser Ser Asn Ile Gly Gln His Asp Leu Asp Thr Lys Thr
                 165                 170                 175    
 Lys Gln Ile Gln Gln Trp Ile Lys Lys Lys His Leu Val Gln Ile Thr
             180                 185                 190        
 Ile Lys Lys Gly Lys Asn Val Asp Val Ser Glu Asn Glu Met Glu Glu
         195                 200                 205            
 Ile Phe His Gln Ile Leu Gln Thr Met Pro Gly Ile Ala Thr Phe Ser
     210                 215                 220                
 Ser Arg Pro Gln Ala Val Gln Gly Gly Lys Ala Leu Met Cys Val Leu
 225                 230                 235                 240
 Arg Ala Leu Ser Lys Asn Glu Glu Lys Ala Tyr Lys Glu Thr Gln Glu
                 245                 250                 255    
 Thr Gln Glu Arg Asp Thr Leu Asn Lys Asp His Gly Asn Asp Lys Glu
             260                 265                 270        
 Ser Asn Val Leu His Gln
         275            



      <210> 310
      <211> 456
      <212> PRT
      <213> Homo sapiens


      <400> 310
 Met Thr Thr Thr Phe Leu Gln Thr Ser Ser Ser Thr Phe Gly Gly Gly
   1               5                  10                  15    
 Ser Thr Arg Gly Gly Ser Leu Leu Ala Gly Gly Gly Gly Phe Gly Gly
              20                  25                  30        
 Gly Ser Leu Ser Gly Gly Gly Gly Ser Arg Ser Ile Ser Ala Ser Ser
          35                  40                  45            
 Ala Arg Phe Val Ser Ser Gly Ser Gly Gly Gly Tyr Gly Gly Gly Met
      50                  55                  60                
 Arg Val Cys Gly Phe Gly Gly Gly Ala Gly Ser Val Phe Gly Gly Gly
  65                  70                  75                  80
 Phe Gly Gly Gly Val Gly Gly Gly Phe Gly Gly Gly Phe Gly Gly Gly
                  85                  90                  95    
 Asp Gly Gly Leu Leu Ser Gly Asn Glu Lys Ile Thr Met Gln Asn Leu
             100                 105                 110        
 Asn Asp Arg Leu Ala Ser Tyr Leu Asp Lys Val Arg Ala Leu Glu Glu
         115                 120                 125            
 Ala Asn Ala Asp Leu Glu Val Lys Ile His Asp Trp Tyr Gln Lys Gln
     130                 135                 140                
 Thr Pro Ala Ser Pro Glu Cys Asp Tyr Ser Gln Tyr Phe Lys Thr Ile
 145                 150                 155                 160
 Glu Glu Leu Arg Asp Lys Ile Met Ala Thr Thr Ile Asp Asn Ser Arg
                 165                 170                 175    
 Val Ile Leu Glu Ile Asp Asn Ala Arg Leu Ala Ala Asp Asp Phe Arg
             180                 185                 190        
 Leu Lys Tyr Glu Asn Glu Leu Ala Leu Arg Gln Gly Val Glu Ala Asp
         195                 200                 205            
 Ile Asn Gly Leu Arg Arg Val Leu Asp Glu Leu Thr Leu Ala Arg Thr
     210                 215                 220                
 Asp Leu Glu Met Gln Ile Glu Gly Leu Asn Glu Glu Leu Ala Tyr Leu
 225                 230                 235                 240
 Lys Lys Asn His Glu Glu Glu Met Lys Glu Phe Ser Ser Gln Leu Ala
                 245                 250                 255    
 Gly Gln Val Asn Val Glu Met Asp Ala Ala Pro Gly Val Asp Leu Thr
             260                 265                 270        
 Arg Val Leu Ala Glu Met Arg Glu Gln Tyr Glu Ala Met Ala Glu Lys
         275                 280                 285            
 Asn Arg Arg Asp Val Glu Ala Trp Phe Phe Ser Lys Thr Glu Glu Leu
     290                 295                 300                
 Asn Lys Glu Val Ala Ser Asn Thr Glu Met Ile Gln Thr Ser Lys Thr
 305                 310                 315                 320
 Glu Ile Thr Asp Leu Arg Arg Thr Met Gln Glu Leu Glu Ile Glu Leu
                 325                 330                 335    
 Gln Ser Gln Leu Ser Met Lys Ala Gly Leu Glu Asn Ser Leu Ala Glu
             340                 345                 350        
 Thr Glu Cys Arg Tyr Ala Thr Gln Leu Gln Gln Ile Gln Gly Leu Ile
         355                 360                 365            
 Gly Gly Leu Glu Ala Gln Leu Ser Glu Leu Arg Cys Glu Met Glu Ala
     370                 375                 380                
 Gln Asn Gln Glu Tyr Lys Met Leu Leu Asp Ile Lys Thr Arg Leu Glu
 385                 390                 395                 400
 Gln Glu Ile Ala Thr Tyr Arg Ser Leu Leu Glu Gly Gln Asp Ala Lys
                 405                 410                 415    
 Met Ala Gly Ile Gly Ile Arg Glu Ala Ser Ser Gly Gly Gly Gly Ser
             420                 425                 430        
 Ser Ser Asn Phe His Ile Asn Val Glu Glu Ser Val Asp Gly Gln Val
         435                 440                 445            
 Val Ser Ser His Lys Arg Glu Ile
     450                 455    



      <210> 311
      <211> 852
      <212> PRT
      <213> Homo sapiens


      <400> 311
 Met Glu Pro Leu Thr Phe Lys Asp Val Ala Ile Glu Phe Ser Leu Glu
   1               5                  10                  15    
 Glu Trp Gln Cys Leu Asp Thr Ala Gln Arg Asp Leu Tyr Arg Asn Val
              20                  25                  30        
 Leu Leu Glu Asn Tyr Arg Asn Leu Val Phe Leu Gly Ile Ala Val Ser
          35                  40                  45            
 Lys Pro Tyr Leu Ile Thr Cys Leu Glu Gln Lys Lys Glu Pro Trp Asn
      50                  55                  60                
 Ile Lys Arg His Glu Met Val Ala Lys Pro Pro Val Met Ser Phe His
  65                  70                  75                  80
 Phe Ala Gln Asp Leu Trp Pro Glu Gln Asn Ile Lys Asp Ser Phe Gln
                  85                  90                  95    
 Lys Val Thr Leu Arg Arg Tyr Gly Lys Cys Glu Tyr Glu Asn Leu Gln
             100                 105                 110        
 Leu Arg Lys Gly Cys Lys His Val Asp Glu Cys Thr Gly His Lys Gly
         115                 120                 125            
 Gly His Asn Thr Val Asn Gln Cys Leu Thr Ala Thr Pro Ser Lys Ile
     130                 135                 140                
 Phe Gln Cys Asn Lys Tyr Val Lys Val Phe Asp Lys Phe Ser Asn Ser
 145                 150                 155                 160
 Asn Arg Tyr Lys Arg Arg His Thr Gly Asn Lys His Phe Lys Cys Lys
                 165                 170                 175    
 Glu Cys Ser Lys Ser Phe Cys Val Leu Ser Gln Leu Thr Gln His Arg
             180                 185                 190        
 Arg Ile His Thr Arg Val Asn Ser Tyr Lys Cys Glu Glu Cys Gly Lys
         195                 200                 205            
 Ala Phe Asn Trp Phe Ser Thr Leu Thr Lys His Lys Arg Ile His Thr
     210                 215                 220                
 Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Asn Gln
 225                 230                 235                 240
 Ser Ser Gln Leu Thr Arg His Lys Ile Ile His Thr Glu Glu Lys Pro
                 245                 250                 255    
 Asn Lys Cys Glu Glu Cys Gly Lys Ala Phe Lys Gln Ala Ser His Leu
             260                 265                 270        
 Thr Ile His Lys Ile Ile His Thr Gly Glu Lys Pro Tyr Lys Tyr Glu
         275                 280                 285            
 Glu Cys Gly Lys Val Phe Ser Gln Ser Ser His Leu Thr Thr Gln Lys
     290                 295                 300                
 Ile Leu His Thr Gly Glu Asn Leu Tyr Lys Cys Lys Glu Cys Gly Lys
 305                 310                 315                 320
 Ala Phe Asn Leu Phe Ser Asn Leu Thr Asn His Lys Arg Ile His Ala
                 325                 330                 335    
 Gly Glu Lys Pro Tyr Lys Cys Lys Glu Cys Gly Arg Ala Phe Asn Ile
             340                 345                 350        
 Ser Ser Asn Leu Asn Lys Gln Glu Lys Ile His Thr Gly Gly Lys Leu
         355                 360                 365            
 Asn Lys Cys Glu Glu Cys Asp Lys Ala Phe Asn Arg Ser Leu Lys Leu
     370                 375                 380                
 Thr Ala His Lys Lys Ile Leu Met Glu Glu Lys Pro Tyr Lys Cys Glu
 385                 390                 395                 400
 Glu Cys Gly Lys Val Phe Asn Gln Phe Ser Thr Leu Thr Arg His Lys
                 405                 410                 415    
 Ile Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Lys Glu Cys Gly Lys
             420                 425                 430        
 Ala Phe Asn Gln Ser Ser Asn Leu Thr Glu His Lys Lys Ile His Thr
         435                 440                 445            
 Ala Glu Lys Ser Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Asn Gln
     450                 455                 460                
 His Ser Asn Leu Ile Asn His Arg Lys Ile Tyr Ser Gly Glu Lys Pro
 465                 470                 475                 480
 Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Asn Arg Ser Ser Thr Leu
                 485                 490                 495    
 Thr Arg His Lys Lys Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu
             500                 505                 510        
 Glu Cys Asp Arg Ala Phe Ser Gln Ser Ser Asn Leu Thr Glu His Lys
         515                 520                 525            
 Lys Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys
     530                 535                 540                
 Ala Phe Asn Arg Phe Ser Thr Leu Thr Lys His Lys Arg Ile His Thr
 545                 550                 555                 560
 Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Asn Gln
                 565                 570                 575    
 Ser Tyr Gln Leu Thr Arg His Lys Ile Val His Thr Lys Glu Lys Leu
             580                 585                 590        
 Asn Lys Cys Glu Glu Phe Gly Lys Ala Phe Lys Gln Ser Ser His Arg
         595                 600                 605            
 Thr Ile His Lys Ile Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu
     610                 615                 620                
 Glu His Gly Lys Val Phe Asn Gln Ser Ser Asn Leu Thr Thr Gln Lys
 625                 630                 635                 640
 Ile Ile His Thr Gly Glu Asn Leu Tyr Lys Phe Glu Glu His Gly Lys
                 645                 650                 655    
 Ala Phe Asn Leu Phe Ser Asn Ile Thr Asn His Lys Ile Ile Tyr Thr
             660                 665                 670        
 Gly Glu Lys Pro His Lys Cys Glu Glu Cys Gly Lys Ala Tyr Asn Arg
         675                 680                 685            
 Phe Ser Asn Leu Thr Ile His Lys Arg Ile His Thr Gly Glu Lys Pro
     690                 695                 700                
 Tyr Gln Cys Ala Glu Cys Gly Lys Ala Phe Asn Cys Ser Ser Thr Leu
 705                 710                 715                 720
 Asn Arg His Lys Ile Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Lys
                 725                 730                 735    
 Glu Cys Gly Lys Ala Phe Asn Leu Ser Ser Thr Leu Thr Ala His Lys
             740                 745                 750        
 Lys Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys
         755                 760                 765            
 Ala Phe Asn Gln Ser Ser Asn Leu Thr Thr His Lys Lys Ile His Thr
     770                 775                 780                
 Ser Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys Ser Phe Asn Gln
 785                 790                 795                 800
 Phe Ser Ser Leu Asn Ile His Lys Ile Ile His Thr Gly Glu Lys Pro
                 805                 810                 815    
 Tyr Lys Cys Gly Asp Tyr Gly Arg Ala Phe Asn Leu Ser Ser Asn Leu
             820                 825                 830        
 Thr Thr His Lys Lys Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu
         835                 840                 845            
 Tyr Gly Lys Thr
     850        



      <210> 312
      <211> 86
      <212> PRT
      <213> Homo sapiens


      <400> 312
 Met Ser Leu Pro Leu Asn Pro Lys Pro Phe Leu Asn Gly Leu Thr Gly
   1               5                  10                  15    
 Lys Pro Val Met Val Lys Leu Lys Trp Gly Met Glu Tyr Lys Gly Tyr
              20                  25                  30        
 Leu Val Ser Val Asp Gly Tyr Met Asn Met Gln Leu Ala Asn Thr Glu
          35                  40                  45            
 Glu Tyr Ile Asp Gly Ala Leu Ser Gly His Leu Gly Glu Val Leu Ile
      50                  55                  60                
 Arg Cys Asn Asn Val Leu Tyr Ile Arg Gly Val Glu Glu Glu Glu Glu
  65                  70                  75                  80
 Asp Gly Glu Met Arg Glu
                  85    



      <210> 313
      <211> 66
      <212> PRT
      <213> Homo sapiens


      <400> 313
 Met Pro Thr Asn Tyr Thr Thr Trp Met Lys Trp Thr Ile Ile Phe Glu
   1               5                  10                  15    
 Met Glu Ser Cys Ser Val Ala Leu Ala Gly Met Gln Trp Tyr Asn His
              20                  25                  30        
 Gly Phe Leu Gln Pro Pro Leu Pro Arg Leu Lys Gln Ser Cys Leu Ser
          35                  40                  45            
 Leu Pro Ser Ser Trp Asp Ser Ala Gln Arg Ser Gly Arg Leu Gln Ser
      50                  55                  60                
 Leu Trp
  65    



      <210> 314
      <211> 1549
      <212> PRT
      <213> Homo sapiens


      <400> 314
 Met Glu Ala Arg Ser Arg Ser Ala Glu Pro Ala Leu Arg Leu Thr Ala
   1               5                  10                  15    
 Lys Asp Trp Ile Pro Arg His Ser Ile Thr Thr Gln Asp Tyr Leu Gln
              20                  25                  30        
 Thr Thr Pro Thr Thr Asp Pro Ser Thr Ile Tyr Asn Pro Asp Ile His
          35                  40                  45            
 Pro Ile Thr Thr Leu Ser Arg Ile Asp Glu His Arg Asp Thr Glu Glu
      50                  55                  60                
 Ala Pro Glu Arg Thr Ala Gly Ala Arg Lys Thr Arg Thr Arg Glu Ile
  65                  70                  75                  80
 Leu Glu Ser Gln Leu Pro Ser Gly Leu Leu Lys Gly Glu Thr Pro Glu
                  85                  90                  95    
 Trp Glu Leu Arg Arg Ala Glu Leu Val Glu Ile Ile Val Glu Thr Glu
             100                 105                 110        
 Ala Gln Thr Gly Val Ser Gly Ile Asn Val Ala Gly Gly Gly Lys Glu
         115                 120                 125            
 Gly Ile Phe Val Arg Glu Leu Arg Glu Asp Ser Pro Ala Ala Arg Ser
     130                 135                 140                
 Leu Ser Leu Gln Glu Gly Asp Gln Leu Leu Ser Ala Arg Val Phe Phe
 145                 150                 155                 160
 Glu Asn Phe Lys Tyr Glu Asp Ala Leu Arg Leu Leu Gln Cys Ala Glu
                 165                 170                 175    
 Pro Tyr Lys Val Ser Phe Cys Leu Lys Arg Thr Val Pro Thr Gly Asp
             180                 185                 190        
 Leu Ala Leu Arg Pro Gly Thr Val Ser Gly Tyr Glu Ile Lys Gly Pro
         195                 200                 205            
 Arg Ala Lys Val Ala Lys Leu Asn Ile Gln Ser Leu Ser Pro Val Lys
     210                 215                 220                
 Lys Lys Lys Met Val Pro Gly Ala Leu Gly Val Pro Ala Asp Leu Ala
 225                 230                 235                 240
 Pro Val Asp Val Glu Phe Ser Phe Pro Lys Phe Ser Arg Leu Arg Arg
                 245                 250                 255    
 Gly Leu Lys Ala Glu Ala Val Lys Gly Pro Val Pro Ala Ala Pro Ala
             260                 265                 270        
 Arg Arg Arg Leu Gln Leu Pro Arg Leu Arg Val Arg Glu Val Ala Glu
         275                 280                 285            
 Glu Ala Gln Ala Ala Arg Leu Ala Ala Ala Ala Pro Pro Pro Arg Lys
     290                 295                 300                
 Ala Lys Val Glu Ala Glu Val Ala Ala Gly Ala Arg Phe Thr Ala Pro
 305                 310                 315                 320
 Gln Val Glu Leu Val Gly Pro Arg Leu Pro Gly Ala Glu Val Gly Val
                 325                 330                 335    
 Pro Gln Val Ser Ala Pro Lys Ala Ala Pro Ser Ala Glu Ala Ala Gly
             340                 345                 350        
 Gly Phe Ala Leu His Leu Pro Thr Leu Gly Leu Gly Ala Pro Ala Pro
         355                 360                 365            
 Pro Ala Val Glu Ala Pro Ala Val Gly Ile Gln Val Pro Gln Val Glu
     370                 375                 380                
 Leu Pro Ala Leu Pro Ser Leu Pro Thr Leu Pro Thr Leu Pro Cys Leu
 385                 390                 395                 400
 Glu Thr Arg Glu Gly Ala Val Ser Val Val Val Pro Thr Leu Asp Val
                 405                 410                 415    
 Ala Ala Pro Thr Val Gly Val Asp Leu Ala Leu Pro Gly Ala Glu Val
             420                 425                 430        
 Glu Ala Arg Gly Glu Ala Pro Glu Val Ala Leu Lys Met Pro Arg Leu
         435                 440                 445            
 Ser Phe Pro Arg Phe Gly Ala Arg Ala Lys Glu Val Ala Glu Ala Lys
     450                 455                 460                
 Val Ala Lys Val Ser Pro Glu Ala Arg Val Lys Gly Pro Arg Leu Arg
 465                 470                 475                 480
 Met Pro Thr Phe Gly Leu Ser Leu Leu Glu Pro Arg Pro Ala Ala Pro
                 485                 490                 495    
 Glu Val Val Glu Ser Lys Leu Lys Leu Pro Thr Ile Lys Met Pro Ser
             500                 505                 510        
 Leu Gly Ile Gly Val Ser Gly Pro Glu Val Lys Val Pro Lys Gly Pro
         515                 520                 525            
 Glu Val Lys Leu Pro Lys Ala Pro Glu Val Lys Leu Pro Lys Val Pro
     530                 535                 540                
 Glu Ala Ala Leu Pro Glu Val Arg Leu Pro Glu Val Glu Leu Pro Lys
 545                 550                 555                 560
 Val Ser Glu Met Lys Leu Pro Lys Val Pro Glu Met Ala Val Pro Glu
                 565                 570                 575    
 Val Arg Leu Pro Glu Val Glu Leu Pro Lys Val Ser Glu Met Lys Leu
             580                 585                 590        
 Pro Lys Val Pro Glu Met Ala Val Pro Glu Val Arg Leu Pro Glu Val
         595                 600                 605            
 Gln Leu Leu Lys Val Ser Glu Met Lys Leu Pro Lys Val Pro Glu Met
     610                 615                 620                
 Ala Val Pro Glu Val Arg Leu Pro Glu Val Gln Leu Pro Lys Val Ser
 625                 630                 635                 640
 Glu Met Lys Leu Pro Glu Val Ser Glu Val Ala Val Pro Glu Val Arg
                 645                 650                 655    
 Leu Pro Glu Val Gln Leu Pro Lys Val Pro Glu Met Lys Val Pro Glu
             660                 665                 670        
 Met Lys Leu Pro Lys Val Pro Glu Met Lys Leu Pro Glu Met Lys Leu
         675                 680                 685            
 Pro Glu Val Gln Leu Pro Lys Val Pro Glu Met Ala Val Pro Asp Val
     690                 695                 700                
 His Leu Pro Glu Val Gln Leu Pro Lys Val Pro Glu Met Lys Leu Pro
 705                 710                 715                 720
 Glu Met Lys Leu Pro Glu Val Lys Leu Pro Lys Val Pro Glu Met Ala
                 725                 730                 735    
 Val Pro Asp Val His Leu Pro Glu Val Gln Leu Pro Lys Val Pro Glu
             740                 745                 750        
 Met Lys Leu Pro Lys Met Pro Glu Met Ala Val Pro Glu Val Arg Leu
         755                 760                 765            
 Pro Glu Val Gln Leu Pro Lys Val Ser Glu Met Lys Leu Pro Lys Val
     770                 775                 780                
 Pro Glu Met Ala Val Pro Asp Val His Leu Pro Glu Val Gln Leu Pro
 785                 790                 795                 800
 Lys Val Cys Glu Met Lys Val Pro Asp Met Lys Leu Pro Glu Ile Lys
                 805                 810                 815    
 Leu Pro Lys Val Pro Glu Met Ala Val Pro Asp Val His Leu Pro Glu
             820                 825                 830        
 Val Gln Leu Pro Lys Val Ser Glu Ile Arg Leu Pro Glu Met Gln Val
         835                 840                 845            
 Pro Lys Val Pro Asp Val His Leu Pro Lys Ala Pro Glu Val Lys Leu
     850                 855                 860                
 Pro Arg Ala Pro Glu Val Gln Leu Lys Ala Thr Lys Ala Glu Gln Ala
 865                 870                 875                 880
 Glu Gly Met Glu Phe Gly Phe Lys Met Pro Lys Met Thr Met Pro Lys
                 885                 890                 895    
 Leu Gly Arg Ala Glu Ser Pro Ser Arg Gly Lys Pro Gly Glu Ala Gly
             900                 905                 910        
 Ala Glu Val Ser Gly Lys Leu Val Thr Leu Pro Cys Leu Gln Pro Glu
         915                 920                 925            
 Val Asp Gly Glu Ala His Val Gly Val Pro Ser Leu Thr Leu Pro Ser
     930                 935                 940                
 Val Glu Leu Asp Leu Pro Gly Ala Leu Gly Leu Gln Gly Gln Val Pro
 945                 950                 955                 960
 Ala Ala Lys Met Gly Lys Gly Glu Arg Val Glu Gly Pro Glu Val Ala
                 965                 970                 975    
 Ala Gly Val Arg Glu Val Gly Phe Arg Val Pro Ser Val Glu Ile Val
             980                 985                 990        
 Thr Pro Gln Leu Pro Ala Val Glu Ile Glu Glu Gly Arg Leu Glu Met
         995                1000                1005            
 Ile Glu Thr Lys Val Lys Pro Ser Ser Lys Phe Ser Leu Pro Lys Phe
    1010                1015                1020                
 Gly Leu Ser Gly Pro Lys Val Ala Lys Ala Glu Ala Glu Gly Ala Gly
1025                1030                1035                1040
 Arg Ala Thr Lys Leu Lys Val Ser Lys Phe Ala Ile Ser Leu Pro Lys
                1045                1050                1055    
 Ala Arg Val Gly Ala Glu Ala Glu Ala Lys Gly Ala Gly Glu Ala Gly
            1060                1065                1070        
 Leu Leu Pro Ala Leu Asp Leu Ser Ile Pro Gln Leu Ser Leu Asp Ala
        1075                1080                1085            
 His Leu Pro Ser Gly Lys Val Glu Val Ala Gly Ala Asp Leu Lys Phe
    1090                1095                1100                
 Lys Gly Pro Arg Phe Ala Leu Pro Lys Phe Gly Val Arg Gly Arg Asp
1105                1110                1115                1120
 Thr Glu Ala Ala Glu Leu Val Pro Gly Val Ala Glu Leu Glu Gly Lys
                1125                1130                1135    
 Gly Trp Gly Trp Asp Gly Arg Val Lys Met Pro Lys Leu Lys Met Pro
            1140                1145                1150        
 Ser Phe Gly Leu Ala Arg Gly Lys Glu Ala Glu Val Gln Gly Asp Arg
        1155                1160                1165            
 Ala Ser Pro Gly Glu Lys Ala Glu Ser Thr Ala Val Gln Leu Lys Ile
    1170                1175                1180                
 Pro Glu Val Glu Leu Val Thr Leu Gly Ala Gln Glu Glu Gly Arg Ala
1185                1190                1195                1200
 Glu Gly Ala Val Ala Val Ser Gly Met Gln Leu Ser Gly Leu Lys Val
                1205                1210                1215    
 Ser Thr Ala Gly Gln Val Val Thr Glu Gly His Asp Ala Gly Leu Arg
            1220                1225                1230        
 Met Pro Pro Leu Gly Ile Ser Leu Pro Gln Val Glu Leu Thr Gly Phe
        1235                1240                1245            
 Gly Glu Ala Gly Thr Pro Gly Gln Gln Ala Gln Ser Thr Val Pro Ser
    1250                1255                1260                
 Ala Glu Gly Thr Ala Gly Tyr Arg Val Gln Val Pro Gln Val Thr Leu
1265                1270                1275                1280
 Ser Leu Pro Gly Ala Gln Val Ala Gly Gly Glu Leu Leu Val Gly Glu
                1285                1290                1295    
 Gly Val Phe Lys Met Pro Thr Val Thr Val Pro Gln Leu Glu Leu Asp
            1300                1305                1310        
 Val Gly Leu Ser Arg Glu Ala Gln Ala Gly Glu Ala Ala Thr Gly Glu
        1315                1320                1325            
 Gly Gly Leu Arg Leu Lys Leu Pro Thr Leu Gly Ala Arg Ala Arg Val
    1330                1335                1340                
 Gly Gly Glu Gly Ala Glu Glu Gln Pro Pro Gly Ala Glu Arg Thr Phe
1345                1350                1355                1360
 Cys Leu Ser Leu Pro Asp Val Glu Leu Ser Pro Ser Gly Gly Asn His
                1365                1370                1375    
 Ala Glu Tyr Gln Val Ala Glu Gly Glu Gly Glu Ala Gly His Lys Leu
            1380                1385                1390        
 Lys Val Arg Leu Pro Arg Phe Gly Leu Val Arg Ala Lys Glu Gly Ala
        1395                1400                1405            
 Glu Glu Gly Glu Lys Ala Lys Ser Pro Lys Leu Arg Leu Pro Arg Val
    1410                1415                1420                
 Gly Phe Ser Gln Ser Glu Met Val Thr Gly Glu Gly Ser Pro Ser Pro
1425                1430                1435                1440
 Glu Glu Glu Glu Glu Glu Glu Glu Glu Gly Ser Gly Glu Gly Ala Ser
                1445                1450                1455    
 Gly Arg Arg Gly Arg Val Arg Val Arg Leu Pro Arg Val Gly Leu Ala
            1460                1465                1470        
 Ala Pro Ser Lys Ala Ser Arg Gly Gln Glu Gly Asp Ala Ala Pro Lys
        1475                1480                1485            
 Ser Pro Val Arg Glu Lys Ser Pro Lys Phe Arg Phe Pro Arg Val Ser
    1490                1495                1500                
 Leu Ser Pro Lys Ala Arg Ser Gly Ser Gly Asp Gln Glu Glu Gly Gly
1505                1510                1515                1520
 Leu Arg Val Arg Leu Pro Ser Val Gly Phe Ser Glu Thr Gly Ala Pro
                1525                1530                1535    
 Gly Pro Ala Arg Met Glu Gly Ala Gln Ala Ala Ala Val
            1540                1545                



      <210> 315
      <211> 731
      <212> PRT
      <213> Homo sapiens


      <400> 315
 Met Leu Lys Glu Trp Ala Ile Lys Gln Gly Ile Leu Leu Lys Val Ala
   1               5                  10                  15    
 Glu Thr Ile Lys Ser Trp Ile Phe Phe Ser Gln Cys Asn Lys Lys Asp
              20                  25                  30        
 Asp Leu Leu His Lys Leu Asp Ile Gly Phe Arg Leu Asp Ser Leu His
          35                  40                  45            
 Thr Ile Leu Gln Gln Glu Val Leu Leu Gln Glu Asp Val Glu Leu Ile
      50                  55                  60                
 Glu Leu Leu Asp Pro Ser Ile Leu Ser Ala Gly Gln Ser Gln Gln Gln
  65                  70                  75                  80
 Glu Asn Gly His Leu Pro Thr Leu Cys Ser Leu Ala Thr Pro Asn Ile
                  85                  90                  95    
 Trp Asp Leu Ser Met Leu Phe Ala Phe Ile Ser Leu Leu Val Met Leu
             100                 105                 110        
 Pro Thr Trp Trp Ile Val Ser Ser Trp Leu Val Trp Gly Val Ile Leu
         115                 120                 125            
 Phe Val Tyr Leu Val Ile Arg Ala Leu Arg Leu Trp Arg Thr Ala Lys
     130                 135                 140                
 Leu Gln Val Thr Leu Lys Lys Tyr Ser Val His Leu Glu Asp Met Ala
 145                 150                 155                 160
 Thr Asn Ser Arg Ala Phe Thr Asn Leu Val Arg Lys Ala Leu Arg Leu
                 165                 170                 175    
 Ile Gln Glu Thr Glu Val Ile Ser Arg Gly Phe Thr Leu Val Ser Ala
             180                 185                 190        
 Ala Cys Pro Phe Asn Lys Ala Gly Gln His Pro Ser Gln His Leu Ile
         195                 200                 205            
 Gly Leu Arg Lys Ala Val Tyr Arg Thr Leu Arg Ala Asn Phe Gln Ala
     210                 215                 220                
 Ala Arg Leu Ala Thr Leu Tyr Met Leu Lys Asn Tyr Pro Leu Asn Ser
 225                 230                 235                 240
 Glu Ser Asp Asn Val Thr Asn Tyr Ile Cys Val Val Pro Phe Lys Glu
                 245                 250                 255    
 Leu Gly Leu Gly Leu Ser Glu Glu Gln Ile Ser Glu Glu Glu Ala His
             260                 265                 270        
 Asn Phe Thr Asp Gly Phe Ser Leu Pro Ala Leu Lys Val Leu Phe Gln
         275                 280                 285            
 Leu Trp Val Ala Gln Ser Ser Glu Phe Phe Arg Arg Leu Ala Leu Leu
     290                 295                 300                
 Leu Ser Thr Ala Asn Ser Pro Pro Gly Pro Leu Leu Thr Pro Ala Leu
 305                 310                 315                 320
 Leu Pro His Arg Ile Leu Ser Asp Val Thr Gln Gly Leu Pro His Ala
                 325                 330                 335    
 His Ser Ala Cys Leu Glu Glu Leu Lys Arg Ser Tyr Glu Phe Tyr Arg
             340                 345                 350        
 Tyr Phe Glu Thr Gln His Gln Ser Val Pro Gln Cys Leu Ser Lys Thr
         355                 360                 365            
 Gln Gln Lys Ser Arg Glu Leu Asn Asn Val His Thr Ala Val Arg Ser
     370                 375                 380                
 Leu Gln Leu His Leu Lys Ala Leu Leu Asn Glu Val Ile Ile Leu Glu
 385                 390                 395                 400
 Asp Glu Leu Glu Lys Leu Val Cys Thr Lys Glu Thr Gln Glu Leu Val
                 405                 410                 415    
 Ser Glu Ala Tyr Pro Ile Leu Glu Gln Lys Leu Lys Leu Ile Gln Pro
             420                 425                 430        
 His Val Gln Ala Ser Asn Asn Cys Trp Glu Glu Ala Ile Ser Gln Val
         435                 440                 445            
 Asp Lys Leu Leu Arg Arg Asn Thr Asp Lys Lys Gly Lys Pro Glu Ile
     450                 455                 460                
 Ala Cys Glu Asn Pro His Cys Thr Val Val Pro Leu Lys Gln Pro Thr
 465                 470                 475                 480
 Leu His Ile Ala Asp Lys Asp Pro Ile Pro Glu Glu Gln Glu Leu Glu
                 485                 490                 495    
 Ala Tyr Val Asp Asp Ile Asp Ile Asp Ser Asp Phe Arg Lys Asp Asp
             500                 505                 510        
 Phe Tyr Tyr Leu Ser Gln Glu Asp Lys Glu Arg Gln Lys Arg Glu His
         515                 520                 525            
 Glu Glu Ser Lys Arg Val Leu Gln Glu Leu Lys Ser Val Leu Gly Phe
     530                 535                 540                
 Lys Ala Ser Glu Ala Glu Arg Gln Lys Trp Lys Gln Leu Leu Phe Ser
 545                 550                 555                 560
 Asp His Ala Val Leu Lys Ser Leu Ser Pro Val Asp Pro Val Glu Pro
                 565                 570                 575    
 Ile Ser Asn Ser Glu Pro Ser Met Asn Ser Asp Met Gly Lys Val Ser
             580                 585                 590        
 Lys Asn Asp Thr Glu Glu Glu Ser Asn Lys Ser Ala Thr Thr Asp Asn
         595                 600                 605            
 Glu Ile Ser Arg Thr Glu Tyr Leu Cys Glu Asn Ser Leu Glu Gly Lys
     610                 615                 620                
 Asn Lys Asp Asn Ser Ser Asn Glu Val Phe Pro Gln Gly Ala Glu Glu
 625                 630                 635                 640
 Arg Met Cys Tyr Gln Cys Glu Ser Glu Asp Glu Pro Gln Ala Asp Gly
                 645                 650                 655    
 Ser Gly Leu Thr Thr Ala Pro Pro Thr Pro Arg Asp Ser Leu Gln Pro
             660                 665                 670        
 Ser Ile Lys Gln Arg Leu Ala Arg Leu Gln Leu Ser Pro Asp Phe Thr
         675                 680                 685            
 Phe Thr Ala Gly Leu Ala Ala Glu Val Ala Ala Arg Ser Leu Ser Phe
     690                 695                 700                
 Thr Thr Met Gln Glu Gln Thr Phe Gly Asp Glu Glu Glu Glu Gln Ile
 705                 710                 715                 720
 Ile Glu Glu Asn Lys Asn Glu Ile Glu Glu Lys
                 725                 730    



      <210> 316
      <211> 894
      <212> PRT
      <213> Homo sapiens


      <400> 316
 Met Gly Gly Glu Leu Phe Lys Pro Gln Gly Arg Ile Leu Phe Arg Ser
   1               5                  10                  15    
 Trp Asp Ile Pro Gly Thr Val Lys His Arg Lys Tyr Leu Trp His Glu
              20                  25                  30        
 Cys Asp Glu Asn Thr Glu Leu Gln Lys Pro Lys Lys Glu Lys Arg Lys
          35                  40                  45            
 Gly Pro Pro Ser Thr Pro Thr Ser Pro Thr Arg Cys Tyr Thr His Gln
      50                  55                  60                
 Asp His Leu Leu Glu Pro Leu Val Ser Ser Leu Ala Ala Arg Met Gly
  65                  70                  75                  80
 Arg Lys Ala Ile Val Leu Ala Ile Ala Asn Thr Ser Leu Ala Phe Pro
                  85                  90                  95    
 Leu Cys Gln Asn Arg Gly Val Ile Glu Gly Asn Phe Gln Arg Lys Val
             100                 105                 110        
 Glu Arg Asp Gly Trp Gly Gly Lys Gly Met Ser Arg Gly Ser Asp Arg
         115                 120                 125            
 Gly Gln Glu Val Ser Ile Glu Asp Gly Leu Pro Leu Ala Leu Glu Thr
     130                 135                 140                
 Glu Glu Gln Arg Lys Arg Tyr Ser Thr Val Val Met Ala Asp Val Ser
 145                 150                 155                 160
 Gln Tyr Pro Val Asn His Leu Val Thr Phe Cys Leu Gly Glu Asp Asp
                 165                 170                 175    
 Gly Val His Thr Val Glu Asp Ala Ser Arg Lys Leu Ala Val Met Asp
             180                 185                 190        
 Ser Gln Gly Arg Val Trp Ala Gln Glu Met Leu Leu Arg Val Ser Pro
         195                 200                 205            
 Asp His Val Thr Leu Leu Asp Pro Ala Ser Lys Val Pro Gly Gly Thr
     210                 215                 220                
 Ser Arg Ser Leu Leu Leu Leu Val Cys Gln Glu Pro Glu Arg Ala Gln
 225                 230                 235                 240
 Pro Asp Val His Phe Phe Gln Gly Leu Arg Leu Gly Ala Glu Leu Ile
                 245                 250                 255    
 Arg Glu Asp Ile Gln Gly Ala Leu His Asn Tyr Arg Ser Gly Arg Gly
             260                 265                 270        
 Glu Arg Arg Ala Ala Ala Leu Arg Ala Thr Gln Glu Glu Leu Gln Arg
         275                 280                 285            
 Asp Arg Ser Pro Ala Ala Glu Thr Pro Pro Leu Gln Arg Arg Pro Ser
     290                 295                 300                
 Val Arg Ala Val Ile Ser Thr Val Glu Arg Gly Ala Gly Arg Gly Arg
 305                 310                 315                 320
 Pro Gln Ala Lys Pro Ile Pro Glu Ala Glu Glu Ala Gln Arg Pro Glu
                 325                 330                 335    
 Pro Val Gly Thr Ser Ser Asn Ala Asp Ser Ala Ser Pro Asp Leu Gly
             340                 345                 350        
 Pro Arg Gly Pro Asp Leu Ala Val Leu Gln Ala Glu Arg Glu Val Asp
         355                 360                 365            
 Ile Leu Asn His Val Phe Asp Asp Val Glu Ser Phe Val Ser Arg Leu
     370                 375                 380                
 Gln Lys Ser Ala Glu Ala Ala Arg Val Leu Glu His Ala Glu Arg Gly
 385                 390                 395                 400
 Arg Arg Ser Arg Arg Arg Ala Ala Gly Glu Gly Leu Leu Thr Leu Arg
                 405                 410                 415    
 Ala Lys Pro Pro Ser Glu Ala Glu Tyr Thr Asp Val Leu Gln Lys Ile
             420                 425                 430        
 Lys Tyr Ala Phe Ser Leu Leu Ala Arg Leu Arg Gly Asn Ile Ala Asp
         435                 440                 445            
 Pro Ser Ser Leu Glu Leu Leu His Phe Leu Phe Gly Pro Leu Gln Met
     450                 455                 460                
 Ile Val Asn Thr Ser Gly Gly Pro Glu Phe Ala Ser Ser Val Arg Arg
 465                 470                 475                 480
 Pro His Leu Thr Ser Asp Ala Val Ala Leu Leu Arg Asp Asn Val Thr
                 485                 490                 495    
 Pro Arg Glu Asn Glu Leu Trp Thr Ser Leu Gly Asp Ser Trp Thr Arg
             500                 505                 510        
 Pro Gly Leu Glu Leu Ser Pro Glu Glu Gly Pro Pro Tyr Arg Pro Glu
         515                 520                 525            
 Phe Phe Ser Gly Trp Glu Pro Pro Val Thr Asp Pro Gln Ser Arg Ala
     530                 535                 540                
 Trp Glu Asp Pro Val Glu Lys Gln Leu Gln His Glu Arg Arg Arg Arg
 545                 550                 555                 560
 Gln Gln Ser Ala Pro Glu Val Ala Val Asn Gly His Arg Asp Leu Glu
                 565                 570                 575    
 Pro Glu Ser Glu Pro Gln Leu Glu Ser Glu Thr Ala Gly Lys Trp Val
             580                 585                 590        
 Leu Cys Asn Tyr Asp Phe Gln Ala Arg Asn Ser Ser Glu Leu Ser Val
         595                 600                 605            
 Lys Gln Arg Asp Val Leu Glu Val Leu Asp Asp Ser Arg Lys Trp Trp
     610                 615                 620                
 Lys Val Arg Asp Pro Ala Gly Gln Glu Gly Tyr Val Pro Tyr Asn Ile
 625                 630                 635                 640
 Leu Thr Pro Tyr Pro Gly Pro Arg Leu His His Ser Gln Ser Pro Ala
                 645                 650                 655    
 Arg Ser Leu Asn Ser Thr Pro Pro Pro Pro Pro Ala Pro Ala Pro Ala
             660                 665                 670        
 Pro Pro Pro Ala Leu Ala Arg Pro Arg Trp Asp Arg Pro Arg Trp Asp
         675                 680                 685            
 Ser Cys Asp Ser Ser Thr Ala Trp Thr Pro Ala Arg Arg Val Ser Glu
     690                 695                 700                
 Lys Phe Ser Gln Met Leu Ile Val Asn Glu Glu Leu Gln Ala Arg Leu
 705                 710                 715                 720
 Ala Gln Gly Arg Ser Gly Pro Ser Arg Ala Val Pro Gly Pro Arg Ala
                 725                 730                 735    
 Pro Glu Pro Gln Leu Ser Pro Gly Ser Asp Ala Ser Glu Val Arg Ala
             740                 745                 750        
 Trp Leu Gln Ala Lys Gly Phe Ser Ser Gly Thr Val Asp Ala Leu Gly
         755                 760                 765            
 Val Leu Thr Gly Ala Gln Leu Phe Ser Leu Gln Arg Glu Glu Leu Arg
     770                 775                 780                
 Ala Val Ser Pro Glu Glu Gly Ala Arg Val Tyr Ser Gln Val Thr Val
 785                 790                 795                 800
 Gln Arg Ser Leu Leu Glu His Leu Gly Ser Ala Leu Leu Ser Asn Gln
                 805                 810                 815    
 Lys Leu Glu Thr Leu Asp Leu Gly Gln Asn His Leu Trp Lys Ser Gly
             820                 825                 830        
 Ile Ile Lys Leu Phe Gly Val Leu Arg Gln Arg Thr Gly Ser Leu Lys
         835                 840                 845            
 Ile Leu Arg Leu Lys Thr Tyr Glu Thr Asn Leu Glu Ile Lys Lys Leu
     850                 855                 860                
 Leu Glu Glu Val Lys Glu Lys Asn Pro Lys Leu Thr Ile Asp Cys Asn
 865                 870                 875                 880
 Ala Ser Gly Ala Thr Ala Pro Pro Cys Cys Asp Phe Phe Cys
                 885                 890                



      <210> 317
      <211> 54
      <212> PRT
      <213> Homo sapiens


      <400> 317
 Met Pro Gly Lys Lys Ala Arg Lys Asn Ala Gln Pro Ser Pro Ala Arg
   1               5                  10                  15    
 Ala Pro Ala Glu Leu Glu Val Glu Cys Ala Thr Gln Leu Arg Arg Phe
              20                  25                  30        
 Gly Asp Lys Leu Asn Phe Arg Gln Lys Leu Leu Asn Leu Ile Ser Lys
          35                  40                  45            
 Leu Phe Cys Ser Gly Thr
      50                



      <210> 318
      <211> 336
      <212> PRT
      <213> Homo sapiens


      <400> 318
 Met Glu Ala Ala Ser Asp Arg Leu Gly Leu Gly Gln Arg Arg Ser Lys
   1               5                  10                  15    
 Thr Met Val Gly Lys Met Trp Pro Val Leu Trp Thr Leu Cys Ala Val
              20                  25                  30        
 Arg Val Thr Val Asp Ala Ile Ser Val Glu Thr Pro Gln Asp Val Leu
          35                  40                  45            
 Arg Ala Ser Gln Gly Lys Ser Val Thr Leu Pro Cys Thr Tyr His Thr
      50                  55                  60                
 Ser Thr Ser Ser Arg Glu Gly Leu Ile Gln Trp Asp Lys Leu Leu Leu
  65                  70                  75                  80
 Thr His Thr Glu Arg Val Val Ile Trp Pro Phe Ser Asn Lys Asn Tyr
                  85                  90                  95    
 Ile His Gly Glu Leu Tyr Lys Asn Arg Val Ser Ile Ser Asn Asn Ala
             100                 105                 110        
 Glu Gln Ser Asp Ala Ser Ile Thr Ile Asp Gln Leu Thr Met Ala Asp
         115                 120                 125            
 Asn Gly Thr Tyr Glu Cys Ser Val Ser Leu Met Ser Asp Leu Glu Gly
     130                 135                 140                
 Asn Thr Lys Ser Arg Val Arg Leu Leu Val Leu Val Pro Pro Ser Lys
 145                 150                 155                 160
 Pro Glu Cys Gly Ile Glu Gly Glu Thr Ile Ile Gly Asn Asn Ile Gln
                 165                 170                 175    
 Leu Thr Cys Gln Ser Lys Glu Gly Ser Pro Thr Pro Gln Tyr Ser Trp
             180                 185                 190        
 Lys Arg Tyr Asn Ile Leu Asn Gln Glu Gln Pro Leu Ala Gln Pro Ala
         195                 200                 205            
 Ser Gly Gln Pro Val Ser Leu Lys Asn Ile Ser Thr Asp Thr Ser Gly
     210                 215                 220                
 Tyr Tyr Ile Cys Thr Ser Ser Asn Glu Glu Gly Thr Gln Phe Cys Asn
 225                 230                 235                 240
 Ile Thr Val Ala Val Arg Ser Pro Ser Met Asn Val Ala Leu Tyr Val
                 245                 250                 255    
 Gly Ile Ala Val Gly Val Val Ala Ala Leu Ile Ile Ile Gly Ile Ile
             260                 265                 270        
 Ile Tyr Cys Cys Cys Cys Arg Gly Lys Asp Asp Asn Thr Glu Asp Lys
         275                 280                 285            
 Glu Asp Ala Arg Pro Asn Arg Glu Ala Tyr Glu Glu Pro Pro Glu Gln
     290                 295                 300                
 Leu Arg Glu Leu Ser Arg Glu Arg Glu Glu Glu Asp Asp Tyr Arg Gln
 305                 310                 315                 320
 Glu Glu Gln Arg Ser Thr Gly Arg Glu Ser Pro Asp His Leu Asp Gln
                 325                 330                 335    





      <210> 319
      <211> 212
      <212> PRT
      <213> Homo sapiens


      <400> 319
 Met Ala Lys Gln Tyr Asp Val Leu Phe Arg Leu Leu Leu Ile Gly Asp
   1               5                  10                  15    
 Ser Gly Val Gly Lys Thr Cys Leu Leu Cys Arg Phe Thr Asp Asn Glu
              20                  25                  30        
 Phe His Ser Ser His Ile Ser Thr Ile Gly Val Asp Phe Lys Met Lys
          35                  40                  45            
 Thr Ile Glu Val Asp Gly Ile Lys Val Arg Ile Gln Ile Trp Asp Thr
      50                  55                  60                
 Ala Gly Gln Glu Arg Tyr Gln Thr Ile Thr Lys Gln Tyr Tyr Arg Arg
  65                  70                  75                  80
 Ala Gln Gly Ile Phe Leu Val Tyr Asp Ile Ser Ser Glu Arg Ser Tyr
                  85                  90                  95    
 Gln His Ile Met Lys Trp Val Ser Asp Val Asp Glu Tyr Ala Pro Glu
             100                 105                 110        
 Gly Val Gln Lys Ile Leu Ile Gly Asn Lys Ala Asp Glu Glu Gln Lys
         115                 120                 125            
 Arg Gln Val Gly Arg Glu Gln Gly Gln Gln Leu Ala Lys Glu Tyr Gly
     130                 135                 140                
 Met Asp Phe Tyr Glu Thr Ser Ala Cys Thr Asn Leu Asn Ile Lys Glu
 145                 150                 155                 160
 Ser Phe Thr Arg Leu Thr Glu Leu Val Leu Gln Ala His Arg Lys Glu
                 165                 170                 175    
 Leu Glu Gly Leu Arg Met Arg Ala Ser Asn Glu Leu Ala Leu Ala Glu
             180                 185                 190        
 Leu Glu Glu Glu Glu Gly Lys Pro Glu Gly Pro Ala Asn Ser Ser Lys
         195                 200                 205            
 Thr Cys Trp Cys
     210        



      <210> 320
      <211> 1082
      <212> PRT
      <213> Homo sapiens


      <400> 320
 Met Arg Ile Asn Gln Tyr Pro Glu Ser Asn Ala Glu Tyr Leu Ala Ser
   1               5                  10                  15    
 Leu Phe Pro Asp Ser Leu Ile Val Lys Gly Phe Asn Val Val Ser Ala
              20                  25                  30        
 Trp Ala Leu Gln Leu Gly Pro Lys Asp Ala Ser Arg Gln Val Tyr Ile
          35                  40                  45            
 Cys Ser Asn Asn Ile Gln Ala Arg Gln Gln Val Ile Glu Leu Ala Arg
      50                  55                  60                
 Gln Leu Asn Phe Ile Pro Ile Asp Leu Gly Ser Leu Ser Ser Ala Arg
  65                  70                  75                  80
 Glu Ile Glu Asn Leu Pro Leu Arg Leu Phe Thr Leu Trp Arg Gly Pro
                  85                  90                  95    
 Val Val Val Ala Ile Ser Leu Ala Thr Phe Phe Phe Leu Tyr Ser Phe
             100                 105                 110        
 Val Arg Asp Val Ile His Pro Tyr Ala Arg Asn Gln Gln Ser Asp Phe
         115                 120                 125            
 Tyr Lys Ile Pro Ile Glu Ile Val Asn Lys Thr Leu Pro Ile Val Ala
     130                 135                 140                
 Ile Thr Leu Leu Ser Leu Val Tyr Leu Ala Gly Leu Leu Ala Ala Ala
 145                 150                 155                 160
 Tyr Gln Leu Tyr Tyr Gly Thr Lys Tyr Arg Arg Phe Pro Pro Trp Leu
                 165                 170                 175    
 Glu Thr Trp Leu Gln Cys Arg Lys Gln Leu Gly Leu Leu Ser Phe Phe
             180                 185                 190        
 Phe Ala Met Val His Val Ala Tyr Ser Leu Cys Leu Pro Met Arg Arg
         195                 200                 205            
 Ser Glu Arg Tyr Leu Phe Leu Asn Met Ala Tyr Gln Gln Ser Thr Leu
     210                 215                 220                
 Gly Tyr Val Ala Leu Leu Ile Ser Thr Phe His Val Leu Ile Tyr Gly
 225                 230                 235                 240
 Trp Lys Arg Ala Phe Glu Glu Glu Tyr Tyr Arg Phe Tyr Thr Pro Pro
                 245                 250                 255    
 Asn Phe Val Leu Ala Leu Val Leu Pro Ser Ile Val Ile Leu Asp Leu
             260                 265                 270        
 Ser Val Glu Val Leu Ala Ser Pro Ala Ala Ala Trp Lys Cys Leu Gly
         275                 280                 285            
 Ala Asn Ile Leu Arg Gly Gly Leu Ser Glu Ile Val Leu Pro Ile Glu
     290                 295                 300                
 Trp Gln Gln Asp Arg Lys Ile Pro Pro Leu Ser Thr Pro Pro Pro Pro
 305                 310                 315                 320
 Ala Met Trp Thr Glu Glu Ala Gly Ala Thr Ala Glu Ala Gln Glu Ser
                 325                 330                 335    
 Gly Ile Arg Asn Lys Ser Ser Ser Ser Ser Gln Ile Pro Val Val Gly
             340                 345                 350        
 Val Val Thr Glu Asp Asp Glu Ala Gln Asp Ser Ile Asp Pro Pro Glu
         355                 360                 365            
 Ser Pro Asp Arg Ala Leu Lys Ala Ala Asn Ser Trp Arg Asn Pro Val
     370                 375                 380                
 Leu Pro His Thr Asn Gly Val Gly Pro Leu Trp Glu Phe Leu Leu Arg
 385                 390                 395                 400
 Leu Leu Lys Ser Gln Ala Ala Ser Gly Thr Leu Ser Leu Ala Phe Thr
                 405                 410                 415    
 Ser Trp Ser Leu Gly Glu Phe Leu Gly Ser Gly Thr Trp Met Lys Leu
             420                 425                 430        
 Glu Thr Ile Ile Leu Ser Lys Leu Thr Gln Glu Gln Lys Ser Lys His
         435                 440                 445            
 Cys Met Phe Ser Leu Ile Ser Gly Ser Leu Pro Phe Leu Lys Lys Lys
     450                 455                 460                
 Val Ser Asp Glu Ile Thr Tyr Ala Glu Asp Thr Ala Asn Ser Ile Ala
 465                 470                 475                 480
 Leu Leu Gly Asp Leu Met Lys Ile Pro Ser Ser Glu Leu Arg Ile Gln
                 485                 490                 495    
 Ile Cys Lys Cys Ile Val Asp Phe Tyr His Ala Glu Pro Pro Lys Lys
             500                 505                 510        
 His Ile Pro Glu Val Asn Cys Thr Ile Met Met Lys Ala Gln Ala Ala
         515                 520                 525            
 Ser Gly Ile Cys Thr His Leu Asn Asp Pro Asp Pro Ser Gly Gln Leu
     530                 535                 540                
 Leu Phe Arg Ser Ser Glu Ile Leu Trp Asn Leu Leu Glu Lys Ser Ser
 545                 550                 555                 560
 Lys Glu Glu Val Ile Gln Gln Leu Ser Asn Leu Glu Cys Leu Leu Ala
                 565                 570                 575    
 Leu Lys Glu Val Phe Lys Asn Leu Phe Met Arg Gly Phe Ser His Tyr
             580                 585                 590        
 Asp Arg Gln Leu Arg Asn Asp Ile Leu Val Ile Thr Thr Ile Ile Ala
         595                 600                 605            
 Gln Asn Pro Glu Ala Pro Met Ile Glu Cys Gly Phe Thr Lys Asp Leu
     610                 615                 620                
 Ile Leu Phe Ala Thr Phe Asn Glu Val Lys Ser Gln Asn Leu Leu Val
 625                 630                 635                 640
 Lys Gly Leu Lys Leu Ser Asn Ser Tyr Glu Asp Phe Glu Leu Lys Lys
                 645                 650                 655    
 Leu Leu Phe Asn Val Ile Val Ile Leu Cys Lys Asp Leu Pro Thr Val
             660                 665                 670        
 Gln Leu Leu Ile Asp Gly Lys Val Ile Leu Ala Leu Phe Thr Tyr Val
         675                 680                 685            
 Lys Lys Pro Glu Lys Gln Lys Ile Ile Asp Trp Ser Ala Ala Gln His
     690                 695                 700                
 Glu Glu Leu Gln Leu His Ala Ile Ala Thr Leu Ser Ser Val Ala Pro
 705                 710                 715                 720
 Leu Leu Ile Glu Glu Tyr Met Ser Cys Gln Gly Asn Ala Arg Val Leu
                 725                 730                 735    
 Ala Phe Leu Glu Trp Cys Glu Ser Glu Asp Pro Phe Phe Ser His Gly
             740                 745                 750        
 Asn Ser Phe His Gly Thr Gly Gly Arg Gly Asn Lys Phe Ala Gln Met
         755                 760                 765            
 Arg Tyr Ser Leu Arg Leu Leu Arg Ala Met Val Tyr Leu Glu Asp Glu
     770                 775                 780                
 Thr Val Asn Lys Asp Leu Cys Glu Lys Gly Thr Ile Gln Gln Met Ile
 785                 790                 795                 800
 Gly Leu His Asp Leu Tyr Leu Val Arg Pro Pro Ile Ser Ser Cys Asp
                 805                 810                 815    
 Leu Glu Cys Arg Asp His Leu Gly Met Gln His Ser Thr Pro Leu Tyr
             820                 825                 830        
 Asp Arg Thr Ile Gln Lys Asp Lys Val His Gln Ile Gly Tyr Arg Leu
         835                 840                 845            
 Arg Leu Gly Phe Gln Ile Ile Ser Pro Ile Asn Gln Asn Phe Thr Glu
     850                 855                 860                
 Glu Thr Val Ile Phe Thr Ile His Ser Thr Gly Leu His Arg Gly Glu
 865                 870                 875                 880
 Gly Lys Gly Lys Arg Glu Gly Ser Ile Ala Phe Gly Ser Val Gly Lys
                 885                 890                 895    
 Ile Gly Glu Ile Trp Asn Glu Ile Tyr Glu Glu Ile Lys Leu Glu Lys
             900                 905                 910        
 Leu Arg Pro Val Thr Thr Asp Lys Lys Ala Leu Glu Ala Ile Thr Thr
         915                 920                 925            
 Ala Ser Glu Asn Ile Gly Lys Met Val Ala Ser Leu Gln Ser Asp Ile
     930                 935                 940                
 Ile Glu Ser Gln Ala Cys Gln Asp Met Gln Asn Glu Gln Lys Val Tyr
 945                 950                 955                 960
 Ala Lys Ile Gln Ala Thr His Lys Gln Arg Glu Leu Ala Asn Lys Ser
                 965                 970                 975    
 Trp Glu Asp Phe Leu Ala Arg Thr Ser Asn Ala Lys Thr Leu Lys Lys
             980                 985                 990        
 Ala Lys Ser Leu Gln Glu Lys Ala Ile Glu Ala Ser Arg Tyr His Lys
         995                1000                1005            
 Arg Pro Gln Asn Ala Ile Phe His Gln Thr His Ile Lys Gly Leu Asn
    1010                1015                1020                
 Thr Thr Val Pro Ser Gly Gly Val Val Thr Val Glu Ser Thr Pro Ala
1025                1030                1035                1040
 Arg Leu Val Gly Gly Pro Leu Val Asp Thr Asp Ile Ala Leu Lys Lys
                1045                1050                1055    
 Leu Pro Ile Arg Gly Gly Ala Leu Gln Arg Val Lys Ala Val Lys Ile
            1060                1065                1070        
 Val Asp Ala Pro Lys Lys Ser Ile Pro Thr
        1075                1080        



      <210> 321
      <211> 336
      <212> PRT
      <213> Homo sapiens


      <400> 321
 Met Gly Pro Leu Ser Ser Met Trp Gly Asp Thr Ser Leu Phe Ser Thr
   1               5                  10                  15    
 Ser Lys Ser Asp His Asp Val Glu Glu Ser Pro Cys His His Gln Thr
              20                  25                  30        
 Thr Asn Lys Lys Ile Leu Arg Glu Lys Asp Asp Ala Lys Asp Pro Lys
          35                  40                  45            
 Ser Leu Arg Ala Ser Ser Ser Leu Ala Val Gln Gly Gly Lys Ile Lys
      50                  55                  60                
 Arg Lys Phe Val Asp Leu Gly Ala Pro Leu Arg Arg Asn Ser Ser Lys
  65                  70                  75                  80
 Gly Lys Lys Trp Lys Glu Lys Glu Lys Glu Ala Ser Arg Phe Ser Ala
                  85                  90                  95    
 Gly Ser Arg Ile Phe Arg Gly Arg Leu Glu Asn Trp Thr Pro Lys Pro
             100                 105                 110        
 Cys Ser Thr Ala Gln Thr Ser Thr Arg Ser Pro Cys Met Pro Phe Ser
         115                 120                 125            
 Trp Phe Asn Asp Ser Arg Lys Gly Ser Tyr Ser Phe Arg Asn Leu Pro
     130                 135                 140                
 Ala Pro Thr Ser Ser Leu Gln Pro Ser Pro Glu Thr Leu Ile Ser Asp
 145                 150                 155                 160
 Lys Lys Gly Ser Lys Asn Phe Thr Phe Asn Asp Asp Phe Ser Pro Ser
                 165                 170                 175    
 Ser Thr Ser Ser Ala Asp Leu Ser Gly Leu Gly Ala Glu Pro Lys Thr
             180                 185                 190        
 Pro Gly Leu Ser Gln Pro Leu Ala Leu Ser Ser Asp Glu Ile Leu Asp
         195                 200                 205            
 Asp Gly Gln Ser Pro Lys His Ser Gln Cys Gln Asn Arg Ala Val Gln
     210                 215                 220                
 Glu Trp Ser Val Gln Gln Val Ser His Trp Leu Met Ser Leu Asn Leu
 225                 230                 235                 240
 Glu Gln Tyr Val Ser Glu Phe Ser Ala Gln Asn Ile Thr Gly Glu Gln
                 245                 250                 255    
 Leu Leu Gln Leu Asp Gly Asn Lys Leu Lys Ala Leu Gly Met Thr Ala
             260                 265                 270        
 Ser Gln Asp Arg Ala Val Val Lys Lys Lys Leu Lys Glu Met Lys Met
         275                 280                 285            
 Ser Leu Glu Lys Ala Arg Lys Ala Gln Glu Lys Met Glu Lys Gln Arg
     290                 295                 300                
 Glu Lys Leu Arg Arg Lys Glu Gln Glu Gln Met Gln Arg Lys Ser Lys
 305                 310                 315                 320
 Lys Thr Glu Lys Met Thr Ser Thr Thr Ala Glu Gly Ala Gly Glu Gln
                 325                 330                 335    





      <210> 322
      <211> 806
      <212> PRT
      <213> Homo sapiens


      <400> 322
 Met Ser Ala Ser Pro Asp Asp Leu Ser Thr Gly Gly Arg Leu Gln Asn
   1               5                  10                  15    
 Met Thr Val Asp Glu Cys Phe Gln Ser Arg Asn Thr Val Leu Gln Gly
              20                  25                  30        
 Gln Pro Phe Gly Gly Val Pro Thr Val Leu Cys Leu Asn Ile Ala Leu
          35                  40                  45            
 Trp Val Leu Val Leu Val Val Tyr Ser Phe Leu Arg Lys Ala Ala Trp
      50                  55                  60                
 Asp Tyr Gly Arg Leu Ala Leu Leu Ile His Asn Asp Ser Leu Thr Ser
  65                  70                  75                  80
 Leu Ile Tyr Gly Glu Gln Ser Glu Lys Thr Ser Pro Ser Glu Thr Ser
                  85                  90                  95    
 Leu Glu Met Glu Arg Arg Asp Lys Gly Phe Cys Ser Trp Phe Phe Asn
             100                 105                 110        
 Ser Ile Thr Met Lys Asp Glu Asp Leu Ile Asn Lys Cys Gly Asp Asp
         115                 120                 125            
 Ala Arg Ile Tyr Ile Val Phe Gln Tyr His Leu Ile Ile Phe Val Leu
     130                 135                 140                
 Ile Ile Cys Ile Pro Ser Leu Gly Ile Ile Leu Pro Ile Asn Tyr Thr
 145                 150                 155                 160
 Gly Ser Val Leu Asp Trp Ser Ser His Phe Ala Arg Thr Thr Ile Val
                 165                 170                 175    
 Asn Val Ser Thr Glu Ser Lys Leu Leu Trp Leu His Ser Leu Leu Ser
             180                 185                 190        
 Phe Phe Tyr Phe Ile Thr Asn Phe Met Phe Met Ala His His Cys Leu
         195                 200                 205            
 Gly Phe Ala Pro Arg Asn Ser Gln Lys Val Thr Arg Thr Leu Met Ile
     210                 215                 220                
 Thr Tyr Val Pro Lys Asp Ile Glu Asp Pro Glu Leu Ile Ile Lys His
 225                 230                 235                 240
 Phe His Glu Ala Tyr Pro Gly Ser Val Val Thr Arg Val His Phe Cys
                 245                 250                 255    
 Tyr Asp Val Arg Asn Leu Ile Asp Leu Asp Asp Gln Arg Arg His Ala
             260                 265                 270        
 Met Arg Gly Arg Leu Phe Tyr Thr Ala Lys Ala Lys Lys Thr Gly Lys
         275                 280                 285            
 Val Met Ile Arg Ile His Pro Cys Ala Arg Leu Cys Phe Cys Lys Cys
     290                 295                 300                
 Trp Thr Cys Phe Lys Glu Val Asp Ala Glu Gln Tyr Tyr Ser Glu Leu
 305                 310                 315                 320
 Glu Glu Gln Leu Thr Asp Glu Phe Asn Ala Glu Leu Asn Arg Val Pro
                 325                 330                 335    
 Leu Lys Arg Leu Asp Leu Ile Phe Val Thr Phe Gln Asp Ser Arg Met
             340                 345                 350        
 Ala Lys Arg Val Arg Lys Asp Tyr Lys Tyr Val Gln Cys Gly Val Gln
         355                 360                 365            
 Pro Gln Gln Ser Ser Val Thr Thr Ile Val Lys Ser Tyr Tyr Trp Arg
     370                 375                 380                
 Val Thr Met Ala Pro His Pro Lys Asp Ile Ile Trp Lys His Leu Ser
 385                 390                 395                 400
 Val Arg Arg Phe Phe Trp Trp Ala Arg Phe Ile Ala Ile Asn Thr Phe
                 405                 410                 415    
 Leu Phe Phe Leu Phe Phe Phe Leu Thr Thr Pro Ala Ile Ile Met Asn
             420                 425                 430        
 Thr Ile Asp Met Tyr Asn Val Thr Arg Pro Ile Glu Lys Leu Gln Asn
         435                 440                 445            
 Pro Ile Val Thr Gln Phe Phe Pro Ser Val Met Leu Trp Gly Phe Thr
     450                 455                 460                
 Val Ile Leu Pro Leu Ile Val Tyr Phe Ser Ala Phe Leu Glu Ala His
 465                 470                 475                 480
 Trp Thr Arg Ser Ser Gln Asn Leu Val Met Val His Lys Cys Tyr Ile
                 485                 490                 495    
 Phe Leu Val Phe Met Val Val Ile Leu Pro Ser Met Gly Leu Thr Ser
             500                 505                 510        
 Leu Asp Val Phe Leu Arg Trp Leu Phe Asp Ile Tyr Tyr Leu Glu Gln
         515                 520                 525            
 Ala Ser Ile Arg Phe Gln Cys Val Phe Leu Pro Asp Asn Gly Ala Phe
     530                 535                 540                
 Phe Val Asn Tyr Val Ile Thr Ala Ala Leu Leu Gly Thr Gly Met Glu
 545                 550                 555                 560
 Leu Leu Arg Leu Gly Ser Leu Phe Cys Tyr Ser Thr Arg Leu Phe Phe
                 565                 570                 575    
 Ser Arg Ser Glu Pro Glu Arg Val Asn Ile Arg Lys Asn Gln Ala Ile
             580                 585                 590        
 Asp Phe Gln Phe Gly Arg Glu Tyr Ala Trp Met Met Asn Val Phe Ser
         595                 600                 605            
 Val Val Met Ala Tyr Ser Ile Thr Cys Pro Ile Ile Val Pro Phe Gly
     610                 615                 620                
 Leu Leu Tyr Leu Cys Met Lys His Leu Thr Asp Arg Tyr Asn Met Tyr
 625                 630                 635                 640
 Tyr Ser Phe Ala Pro Thr Lys Leu Asn Glu Gln Ile His Met Ala Ala
                 645                 650                 655    
 Val Ser Gln Ala Ile Phe Ala Pro Leu Leu Gly Leu Phe Trp Met Leu
             660                 665                 670        
 Phe Phe Ser Ile Leu Arg Leu Gly Ser Leu His Ala Ile Thr Ile Phe
         675                 680                 685            
 Ser Leu Ser Thr Leu Leu Ile Ala Met Val Ile Ala Phe Val Gly Ile
     690                 695                 700                
 Phe Leu Gly Lys Leu Arg Met Val Ala Asp Tyr Glu Pro Glu Glu Glu
 705                 710                 715                 720
 Glu Ile Gln Thr Val Phe Asp Met Glu Pro Ser Ser Thr Ser Ser Thr
                 725                 730                 735    
 Pro Thr Ser Leu Leu Tyr Val Ala Thr Val Leu Gln Glu Pro Glu Leu
             740                 745                 750        
 Asn Leu Thr Pro Ala Ser Ser Pro Ala Arg His Thr Tyr Gly Thr Met
         755                 760                 765            
 Asn Asn Gln Pro Glu Glu Gly Glu Glu Glu Ser Gly Leu Arg Gly Phe
     770                 775                 780                
 Ala Arg Glu Leu Asp Ser Ala Gln Phe Gln Glu Gly Leu Glu Leu Glu
 785                 790                 795                 800
 Gly Gln Asn Gln Tyr His
                 805    



      <210> 323
      <211> 412
      <212> PRT
      <213> Homo sapiens


      <400> 323
 Met Gly Gln Asp Gln Thr Lys Gln Gln Ile Glu Lys Gly Leu Gln Leu
   1               5                  10                  15    
 Tyr Gln Ser Asn Gln Thr Glu Lys Ala Leu Gln Val Trp Thr Lys Val
              20                  25                  30        
 Leu Glu Lys Ser Ser Asp Leu Met Gly Arg Phe Arg Val Leu Gly Cys
          35                  40                  45            
 Leu Val Thr Ala His Ser Glu Met Gly Arg Tyr Lys Glu Met Leu Lys
      50                  55                  60                
 Phe Ala Val Val Gln Ile Asp Thr Ala Arg Glu Leu Glu Asp Ala Asp
  65                  70                  75                  80
 Phe Leu Leu Glu Ser Tyr Leu Asn Leu Ala Arg Ser Asn Glu Lys Leu
                  85                  90                  95    
 Cys Glu Phe His Lys Thr Ile Ser Tyr Cys Lys Thr Cys Leu Gly Val
             100                 105                 110        
 Pro Gly Thr Arg Ala Gly Ala Gln Leu Gly Gly Gln Val Ser Leu Ser
         115                 120                 125            
 Met Gly Asn Ala Phe Leu Gly Leu Ser Val Phe Gln Lys Ala Leu Glu
     130                 135                 140                
 Ser Phe Glu Lys Ala Leu Arg Tyr Ala His Asn Asn Asp Asp Thr Met
 145                 150                 155                 160
 Leu Glu Cys Arg Val Cys Cys Ser Leu Gly Ser Phe Tyr Ala Gln Val
                 165                 170                 175    
 Lys Asp Tyr Glu Lys Ala Leu Phe Phe Pro Cys Lys Ala Ala Glu Leu
             180                 185                 190        
 Val Asn Asn Tyr Gly Lys Gly Trp Ser Leu Lys Tyr Arg Ala Met Ser
         195                 200                 205            
 Gln Tyr His Met Ala Val Ala Tyr Arg Leu Leu Gly Arg Leu Gly Ser
     210                 215                 220                
 Ala Met Glu Cys Cys Glu Glu Ser Met Lys Ile Ala Leu Gln His Gly
 225                 230                 235                 240
 Asp Arg Pro Leu Gln Ala Leu Cys Leu Leu Cys Phe Ala Asp Ile His
                 245                 250                 255    
 Arg Ser Arg Gly Asp Leu Glu Thr Ala Phe Pro Arg Tyr Asp Ser Ala
             260                 265                 270        
 Met Ser Ile Met Thr Glu Ile Gly Asn Arg Leu Gly Gln Val Gln Ala
         275                 280                 285            
 Leu Leu Gly Val Ala Lys Cys Trp Val Ala Arg Lys Ala Leu Asp Lys
     290                 295                 300                
 Ala Leu Asp Ala Ile Glu Arg Ala Gln Asp Leu Ala Glu Glu Val Gly
 305                 310                 315                 320
 Asn Lys Leu Ser Gln Leu Lys Leu His Cys Leu Ser Glu Ser Ile Tyr
                 325                 330                 335    
 Arg Ser Lys Gly Leu Gln Arg Glu Leu Arg Ala His Val Val Arg Phe
             340                 345                 350        
 His Glu Cys Val Glu Glu Thr Glu Leu Tyr Cys Gly Leu Cys Gly Glu
         355                 360                 365            
 Ser Ile Gly Glu Lys Asn Ser Arg Leu Gln Ala Leu Pro Cys Ser His
     370                 375                 380                
 Ile Phe His Leu Arg Cys Leu Gln Asn Asn Gly Thr Arg Ser Cys Pro
 385                 390                 395                 400
 Asn Cys Arg Arg Ser Ser Met Lys Pro Gly Phe Val
                 405                 410        



      <210> 324
      <211> 385
      <212> PRT
      <213> Homo sapiens


      <400> 324
 Met Val Ser Val Thr Met Ala Thr Ser Glu Trp Ile Gln Phe Phe Lys
   1               5                  10                  15    
 Glu Ala Gly Ile Pro Pro Gly Pro Ala Val Asn Tyr Ala Val Met Phe
              20                  25                  30        
 Val Asp Asn Arg Ile Gln Lys Ser Met Leu Leu Asp Leu Asn Lys Glu
          35                  40                  45            
 Ile Met Asn Glu Leu Gly Val Thr Val Val Gly Asp Ile Ile Ala Ile
      50                  55                  60                
 Leu Lys His Ala Lys Val Val His Arg Gln Asp Met Cys Lys Ala Ala
  65                  70                  75                  80
 Thr Glu Ser Val Pro Cys Ser Pro Ser Pro Leu Ala Gly Glu Ile Arg
                  85                  90                  95    
 Arg Gly Thr Ser Ala Ala Ser Arg Met Ile Thr Asn Ser Leu Asn His
             100                 105                 110        
 Asp Ser Pro Pro Ser Thr Pro Pro Arg Arg Pro Asp Thr Ser Thr Ser
         115                 120                 125            
 Lys Ile Ser Val Thr Val Ser Asn Lys Met Ala Ala Lys Ser Ala Lys
     130                 135                 140                
 Ala Thr Ala Ala Leu Ala Arg Arg Glu Glu Glu Ser Leu Ala Val Pro
 145                 150                 155                 160
 Ala Lys Arg Arg Arg Val Thr Ala Glu Met Glu Gly Lys Tyr Val Ile
                 165                 170                 175    
 Asn Met Pro Lys Gly Thr Thr Pro Arg Thr Arg Lys Ile Leu Glu Gln
             180                 185                 190        
 Gln Gln Ala Ala Lys Gly Leu His Arg Thr Ser Val Phe Asp Arg Leu
         195                 200                 205            
 Gly Ala Glu Thr Lys Ala Asp Thr Thr Thr Gly Ser Lys Pro Thr Gly
     210                 215                 220                
 Val Phe Ser Arg Leu Gly Ala Thr Pro Glu Thr Asp Glu Asp Leu Ala
 225                 230                 235                 240
 Trp Asp Ser Asp Asn Asp Ser Ser Ser Ser Val Leu Gln Tyr Ala Gly
                 245                 250                 255    
 Val Leu Lys Lys Leu Gly Arg Gly Pro Ala Lys Ala Ser Pro Gln Pro
             260                 265                 270        
 Ala Leu Thr Val Lys Ala Lys Ala Thr Ser Ser Ala Thr Thr Ala Ala
         275                 280                 285            
 Ala Pro Thr Leu Arg Arg Leu Ala Leu Ser Ser Arg Ser Gly Leu Glu
     290                 295                 300                
 Arg Lys Pro Glu Ser Leu Ser Lys Val Ser Ile Ile Lys Arg Leu Gly
 305                 310                 315                 320
 Ala Ala Ala Leu Val Pro Glu Ala Gln Asp Ser Gln Val Thr Ser Thr
                 325                 330                 335    
 Lys Ser Lys Ser Ser Ala Glu Val Lys Val Thr Ile Lys Arg Thr Leu
             340                 345                 350        
 Val Gly Pro Arg Gly Ser Ser Ser Ser Glu Gly Leu Gly Ala Gln Met
         355                 360                 365            
 Asp His Ala Gly Thr Val Ser Val Phe Lys Arg Leu Gly Arg Arg Thr
     370                 375                 380                
 Phe
 385



      <210> 325
      <211> 1273
      <212> PRT
      <213> Homo sapiens


      <400> 325
 Met Ile Gln Val Asn His Glu Tyr Leu Ser Phe Arg Asp Lys Leu Tyr
   1               5                  10                  15    
 Trp Thr His Gly Tyr Val Leu Ile Ser Lys Glu Val Glu Asp Cys Val
              20                  25                  30        
 Pro Val Phe Leu Lys His Ile Ala His Asp Ile Tyr Val Cys Gly Lys
          35                  40                  45            
 Thr Ile Asn Leu Leu Lys Leu Cys Cys Pro Arg His Tyr Leu Cys Trp
      50                  55                  60                
 Ser Asp Val Pro Val Pro Arg Ile Ser Val Ile Phe Ser Leu Glu Glu
  65                  70                  75                  80
 Leu Lys Glu Ile Glu Lys Asp Cys Ala Val Tyr Val Gly Arg Met Glu
                  85                  90                  95    
 Arg Val Ala Arg His Ser Ser Val Ser Lys Glu Glu Lys Glu Leu Arg
             100                 105                 110        
 Met Glu Ile Ala Lys Gln Glu Leu Ile Ala His Ala Arg Glu Ala Ala
         115                 120                 125            
 Ser Arg Val Leu Ser Ala Leu Ser Asp Arg Gln Met Ser Glu Arg Met
     130                 135                 140                
 Ala Leu Asp Ala Arg Lys Arg Glu Gln Phe Gln Arg Leu Lys Glu Gln
 145                 150                 155                 160
 Phe Val Lys Asp Gln Glu Arg Arg Gln Ala Ala Arg Gln Glu Glu Leu
                 165                 170                 175    
 Asp Asp Asp Phe Ser Tyr Ala Arg Glu Leu Arg Asp Arg Glu Arg Arg
             180                 185                 190        
 Leu Lys Ser Leu Glu Glu Glu Leu Glu Arg Lys Ala Arg Gln Ala Leu
         195                 200                 205            
 Val Asp His Tyr Ser Lys Leu Ser Ala Glu Ala Ala Arg Arg Glu Gln
     210                 215                 220                
 Lys Ala Leu Trp Arg Ile Gln Arg His Arg Leu Glu Ser Ala Arg Leu
 225                 230                 235                 240
 Arg Phe Leu Leu Glu Asp Glu Lys His Ile Gln Glu Met Leu Lys Ala
                 245                 250                 255    
 Val Ser Glu Ala His Gln Pro Gln Glu Pro Pro Asp Val Leu Leu Ser
             260                 265                 270        
 Val His Pro Gln Val Thr Ser Pro Gly Pro Glu His Pro Glu Gly Gly
         275                 280                 285            
 Gln Gly Cys Asp Ser Gly Ser Ala Glu Gln His Ser Pro Ala Trp Asp
     290                 295                 300                
 Gly Trp Asn Arg Pro Gly Leu Leu Thr Pro Gln Pro Leu Lys Pro Leu
 305                 310                 315                 320
 Ala Val Gly Ala Gly Gly Arg Gly Leu Gln Gln Ala Glu Gly Ala Arg
                 325                 330                 335    
 Pro Phe Ser Asp Ser Leu Ser Ile Gly Asp Phe Leu Pro Val Gly Pro
             340                 345                 350        
 Gly Ala Glu Pro Ser Val Gln Thr Gly Met Val Pro Leu Leu Glu Val
         355                 360                 365            
 Ala Leu Gln Thr Ile Asn Leu Asp Leu Pro Pro Ser Ala Pro Gly Glu
     370                 375                 380                
 Ala Pro Ala Ala Ala Ser Thr Gln Pro Ser Arg Pro Gln Glu Tyr Asp
 385                 390                 395                 400
 Phe Ser Thr Val Leu Arg Pro Ala Val Ala Thr Ser Pro Ala Pro Gly
                 405                 410                 415    
 Pro Leu Gln Ala Ala Glu Cys Ser Leu Gly Ser Ser Gly Leu Gln Leu
             420                 425                 430        
 Trp Glu Asp Ser Cys Gly Lys Met Asp Ala Cys Gly Ser Ala Ser Arg
         435                 440                 445            
 Glu Thr Leu Leu Pro Ser His Pro Pro Arg Arg Ala Ala Leu Glu Glu
     450                 455                 460                
 Gly Ser Ser Gln Pro Thr Glu Arg Leu Phe Gly Gln Val Ser Gly Gly
 465                 470                 475                 480
 Gly Leu Pro Thr Gly Asp Tyr Ala Ser Glu Ile Ala Pro Thr Arg Pro
                 485                 490                 495    
 Arg Trp Asn Thr His Gly His Val Ser Asp Ala Ser Ile Arg Val Gly
             500                 505                 510        
 Glu Asn Val Ser Asp Val Ala Pro Thr Gln Pro Arg Trp Asn Thr His
         515                 520                 525            
 Gly His Val Ser Asn Ala Ser Ile Ser Leu Gly Glu Ser Val Ser Asp
     530                 535                 540                
 Val Ala Pro Thr Arg Pro Arg Trp Asn Ile His Gly His Val Ser Asn
 545                 550                 555                 560
 Ala Ser Ile Arg Val Gly Glu Asn Val Ser Asp Val Ala Pro Thr Arg
                 565                 570                 575    
 Pro Arg Trp Asn Thr His Gly His Val Ser Asn Ala Ser Ile Arg Val
             580                 585                 590        
 Gly Glu Asn Val Ser Asp Val Ala Pro Thr Arg Pro Arg Trp Asn Thr
         595                 600                 605            
 His Gly His Val Ser Asp Ala Ser Ile Ser Leu Gly Glu Ser Val Ser
     610                 615                 620                
 Asp Met Ala Pro Ala Arg Pro Arg Trp Asn Thr His Gly His Val Ser
 625                 630                 635                 640
 Asp Ala Ser Ile Ser Leu Gly Glu Ser Val Ser Asp Met Ala Pro Thr
                 645                 650                 655    
 Arg Pro Arg Trp Asn Thr His Gly His Val Ser Asp Thr Ser Ile Arg
             660                 665                 670        
 Val Gly Glu Asn Val Ser Asp Val Ala Pro Ile Arg Ser Arg Cys Asn
         675                 680                 685            
 Thr His Gly His Val Ser Asp Ala Ser Ile Ser Leu Gly Glu Pro Val
     690                 695                 700                
 Ser Asp Val Val Ser Thr Arg Pro Arg Trp Asn Thr His Val Pro Ile
 705                 710                 715                 720
 Pro Pro Pro His Met Val Leu Gly Ala Leu Ser Pro Glu Ala Glu Pro
                 725                 730                 735    
 Asn Thr Pro Arg Pro Gln Gln Ser Pro Pro Gly His Thr Ser Gln Ser
             740                 745                 750        
 Ala Leu Ser Leu Gly Ala Gln Ser Thr Val Leu Asp Cys Gly Pro Arg
         755                 760                 765            
 Leu Pro Val Glu Val Gly Pro Ser Leu Ser Ser Pro Ser Ser Gly Cys
     770                 775                 780                
 Gly Glu Gly Ser Ile Ser Val Gly Glu Asn Val Ser Asp Val Ala Pro
 785                 790                 795                 800
 Thr Gln Pro Trp Trp Pro Asn Thr Pro Gly Asp Ser Val Ser Glu Glu
                 805                 810                 815    
 Leu Gly Pro Gly Arg Ser Gly Asp Thr Glu Asp Leu Ser Pro Asn Trp
             820                 825                 830        
 Pro Leu Asn Ser Gln Glu Asp Thr Ala Ala Gln Ser Ser Pro Gly Arg
         835                 840                 845            
 Gly Glu Glu Ala Glu Ala Ser Ala Ala Glu Ala Gln Gly Gly Glu Gln
     850                 855                 860                
 Ala Tyr Leu Ala Gly Leu Ala Gly Gln Tyr His Leu Glu Arg Tyr Pro
 865                 870                 875                 880
 Asp Ser Tyr Glu Ser Met Ser Glu Pro Pro Ile Ala His Leu Leu Arg
                 885                 890                 895    
 Pro Val Leu Pro Arg Ala Phe Ala Phe Pro Val Asp Pro Gln Val Gln
             900                 905                 910        
 Ser Ala Ala Asp Glu Thr Ala Val Gln Leu Ser Glu Leu Leu Thr Leu
         915                 920                 925            
 Pro Val Leu Met Lys Arg Ser Ile Thr Ala Pro Leu Ala Ala His Ile
     930                 935                 940                
 Ser Leu Val Asn Lys Ala Ala Val Asp Tyr Phe Phe Val Glu Leu His
 945                 950                 955                 960
 Leu Glu Ala His Tyr Glu Ala Leu Arg His Phe Leu Leu Met Glu Asp
                 965                 970                 975    
 Gly Glu Phe Ala Gln Ser Leu Ser Asp Leu Leu Phe Glu Lys Val Ala
             980                 985                 990        
 Ser Gly His Gly Leu Gly Ala Gly Gln Thr Pro Gly Glu Leu Leu Asn
         995                1000                1005            
 Pro Leu Val Leu Asn Ser Val Leu Ser Lys Ala Leu Gln Cys Ser Leu
    1010                1015                1020                
 His Gly Asp Thr Pro His Ala Ser Asn Leu Ser Leu Ala Leu Lys Tyr
1025                1030                1035                1040
 Leu Pro Glu Val Phe Ala Pro Asn Ala Pro Asp Val Leu Ser Cys Leu
                1045                1050                1055    
 Glu Leu Arg Tyr Lys Val Asp Trp Pro Leu Asn Ile Val Ile Thr Glu
            1060                1065                1070        
 Gly Cys Leu Ser Lys Tyr Ser Gly Val Phe Ser Phe Leu Leu Gln Leu
        1075                1080                1085            
 Lys Leu Met Met Trp Ala Leu Lys Asp Val Cys Phe His Leu Lys Arg
    1090                1095                1100                
 Thr Ala Leu Leu Ser His Met Ala Gly Ser Val Gln Phe Arg Gln Leu
1105                1110                1115                1120
 Gln Leu Phe Lys His Glu Met Gln His Phe Val Lys Val Ile Gln Gly
                1125                1130                1135    
 Tyr Ile Ala Asn Gln Ile Leu His Val Thr Trp Cys Glu Phe Arg Ala
            1140                1145                1150        
 Arg Leu Ala Thr Val Gly Asp Leu Glu Glu Ile Gln Arg Ala His Ala
        1155                1160                1165            
 Glu Tyr Leu His Lys Ala Val Phe Arg Gly Leu Leu Thr Glu Lys Ala
    1170                1175                1180                
 Ala Pro Val Met Asn Val Ile His Ser Ile Phe Ser Leu Val Leu Lys
1185                1190                1195                1200
 Phe Arg Ser Gln Leu Ile Ser Gln Ala Trp Gly Pro Pro Gly Gly Pro
                1205                1210                1215    
 Arg Gly Ala Glu His Pro Asn Phe Ala Leu Met Gln Gln Ser Tyr Asn
            1220                1225                1230        
 Thr Phe Lys Tyr Tyr Ser His Phe Leu Phe Lys Val Val Thr Lys Leu
        1235                1240                1245            
 Val Asn Arg Gly Tyr Gln Pro His Leu Glu Asp Phe Leu Leu Arg Ile
    1250                1255                1260                
 Asn Phe Asn Asn Tyr Tyr Gln Asp Ala
1265                1270            



      <210> 326
      <211> 64
      <212> PRT
      <213> Homo sapiens


      <400> 326
 Met Ala His Cys Ser Leu Asn Leu Pro Gly Ser Asp Asp Pro Pro Ala
   1               5                  10                  15    
 Ser Ala Ser Gln Val Ala Arg Thr Thr Gly Ala Arg His His Ala Gln
              20                  25                  30        
 Leu Ile Phe Val Phe Phe Val Glu Met Gly Phe His Tyr Ile Ser Gln
          35                  40                  45            
 Ala Gly Leu Glu Leu Trp Ala Gln Ala Ile Leu Leu Pro Gln Pro Pro
      50                  55                  60                





      <210> 327
      <211> 140
      <212> PRT
      <213> Homo sapiens


      <400> 327
 Met Gly Arg Ser Arg Ser Arg Ser Pro Arg Arg Glu Arg Arg Arg Ser
   1               5                  10                  15    
 Arg Ser Thr Ser Arg Glu Arg Glu Arg Arg Arg Arg Glu Arg Ser Arg
              20                  25                  30        
 Ser Arg Glu Arg Asp Arg Arg Arg Ser Arg Ser Arg Ser Pro His Arg
          35                  40                  45            
 Arg Arg Ser Arg Ser Pro Arg Arg His Arg Ser Thr Ser Pro Ser Pro
      50                  55                  60                
 Ser Arg Leu Lys Glu Arg Arg Asp Glu Glu Lys Lys Glu Thr Lys Glu
  65                  70                  75                  80
 Thr Lys Ser Lys Glu Arg Gln Ile Thr Glu Glu Asp Leu Glu Gly Lys
                  85                  90                  95    
 Thr Glu Glu Glu Ile Glu Met Met Lys Leu Met Gly Phe Ala Ser Phe
             100                 105                 110        
 Asp Ser Thr Lys Gly Lys Lys Val Asp Gly Ser Val Asn Ala Tyr Ala
         115                 120                 125            
 Ile Asn Val Ser Gln Lys Arg Lys Tyr Arg Tyr Ala
     130                 135                 140



      <210> 328
      <211> 31
      <212> PRT
      <213> Homo sapiens


      <400> 328
 Met Trp Trp Leu Met Pro Ile Ile Pro Ala Leu Leu Glu Ala Glu Ala
   1               5                  10                  15    
 Arg Gly Leu Leu Glu Ala Arg Asn Leu Arg Gln Ala Trp Ala Thr
              20                  25                  30    



      <210> 329
      <211> 562
      <212> PRT
      <213> Homo sapiens


      <400> 329
 Met Glu Ile Ala Ser Phe Val Gly Pro Asn Val Asn Thr Val Gly Asn
   1               5                  10                  15    
 Leu Arg Pro Ala Gln Ser Ala Ala Gly Asp Gly Asp Glu Val Gln Ser
              20                  25                  30        
 Val His Ser Gln Arg Gln Asp Cys Gln Ala Thr Gly Ser Leu Ser Asn
          35                  40                  45            
 Gly Glu Asn Asn Glu Lys Asn Ala Phe Thr Thr Tyr Gln Gln Glu Thr
      50                  55                  60                
 Lys Asn Thr Thr Thr Pro Gln Ser Val Tyr Phe Leu Gly Val Asn Lys
  65                  70                  75                  80
 Met Ser Ser Gln His Arg Glu Gly Ser Arg Gly Thr Ser Pro Pro Leu
                  85                  90                  95    
 Pro Val Leu Ala Cys Phe Glu Leu Ala Val Ala Arg Val Gly Pro Arg
             100                 105                 110        
 Thr Pro Glu Val Val Arg Arg Ser Leu Ala Ala Glu Gly Ala Gly Ser
         115                 120                 125            
 Arg Gly Leu Asp Cys Phe Arg Leu Ala Arg Arg Ser Lys Met Ala Asp
     130                 135                 140                
 Ile Ser Leu Asp Glu Leu Ile Arg Lys Arg Gly Ala Ala Ala Lys Gly
 145                 150                 155                 160
 Arg Leu Asn Ala Arg Pro Gly Val Gly Gly Val Arg Ser Arg Val Gly
                 165                 170                 175    
 Ile Gln Gln Gly Leu Leu Ser Gln Ser Thr Arg Thr Ala Thr Phe Gln
             180                 185                 190        
 Gln Arg Phe Asp Ala Arg Gln Lys Ile Gly Leu Ser Asp Ala Arg Leu
         195                 200                 205            
 Lys Leu Gly Val Lys Asp Ala Arg Glu Lys Leu Leu Gln Lys Asp Ala
     210                 215                 220                
 Arg Phe Arg Ile Lys Gly Lys Val Gln Asp Ala Arg Glu Met Leu Asn
 225                 230                 235                 240
 Ser Arg Lys Gln Gln Thr Thr Val Pro Gln Lys Pro Arg Gln Val Ala
                 245                 250                 255    
 Asp Ala Arg Glu Lys Ile Ser Leu Lys Arg Ser Ser Pro Ala Ala Phe
             260                 265                 270        
 Ile Asn Pro Pro Ile Gly Thr Val Thr Pro Ala Leu Lys Leu Thr Lys
         275                 280                 285            
 Thr Ile Gln Val Pro Gln Gln Lys Ala Met Ala Pro Leu His Pro His
     290                 295                 300                
 Pro Ala Gly Met Arg Ile Asn Val Val Asn Asn His Gln Ala Lys Gln
 305                 310                 315                 320
 Asn Leu Tyr Asp Leu Asp Glu Asp Asp Asp Gly Ile Ala Ser Val Pro
                 325                 330                 335    
 Thr Lys Gln Met Lys Phe Ala Ala Ser Gly Gly Phe Leu His His Met
             340                 345                 350        
 Ala Gly Leu Ser Ser Ser Lys Leu Ser Met Ser Lys Ala Leu Pro Leu
         355                 360                 365            
 Thr Lys Val Val Gln Asn Asp Ala Tyr Thr Ala Pro Ala Leu Pro Ser
     370                 375                 380                
 Ser Ile Arg Thr Lys Ala Leu Thr Asn Met Ser Arg Thr Leu Val Asn
 385                 390                 395                 400
 Lys Glu Glu Pro Pro Lys Glu Leu Pro Ala Ala Glu Pro Val Leu Ser
                 405                 410                 415    
 Pro Leu Glu Gly Thr Lys Met Thr Val Asn Asn Leu His Pro Arg Val
             420                 425                 430        
 Thr Glu Glu Asp Ile Val Glu Leu Phe Cys Val Cys Gly Ala Leu Lys
         435                 440                 445            
 Arg Ala Arg Leu Val His Pro Gly Val Ala Glu Val Val Phe Val Lys
     450                 455                 460                
 Lys Asp Asp Ala Ile Thr Ala Tyr Lys Lys Tyr Asn Asn Arg Cys Leu
 465                 470                 475                 480
 Asp Gly Gln Pro Met Lys Cys Asn Leu His Met Asn Gly Asn Val Ile
                 485                 490                 495    
 Thr Ser Asp Gln Pro Ile Leu Leu Arg Leu Ser Asp Ser Pro Ser Met
             500                 505                 510        
 Lys Lys Glu Ser Glu Leu Pro Arg Arg Val Asn Ser Ala Ser Ser Ser
         515                 520                 525            
 Asn Pro Pro Ala Glu Val Asp Pro Asp Thr Ile Leu Lys Ala Leu Phe
     530                 535                 540                
 Lys Ser Ser Gly Ala Ser Val Thr Thr Gln Pro Thr Glu Phe Lys Ile
 545                 550                 555                 560
 Lys Leu
        



      <210> 330
      <211> 48
      <212> PRT
      <213> Homo sapiens


      <400> 330
 Met Ser Phe Ser Ser Pro Ser Met Asn Trp Gln Glu Lys Phe Ser Cys
   1               5                  10                  15    
 Gln Ala Gln Trp Leu Thr Pro Val Leu Pro Ala Leu Trp Glu Ala Glu
              20                  25                  30        
 Val Gly Ala Leu Leu Glu Pro Arg Ser Leu Arg Pro Ala Trp Ala Thr
          35                  40                  45            





      <210> 331
      <211> 217
      <212> PRT
      <213> Homo sapiens


      <400> 331
 Met Leu Gln Thr Lys Pro Gly Pro Pro Lys Lys Pro Lys Thr Pro Ser
   1               5                  10                  15    
 Arg Pro Ser Ala Leu Ala Tyr Cys Tyr His Cys Ala Gln Lys Gly His
              20                  25                  30        
 Tyr Gly His Glu Cys Pro Glu Arg Glu Val Tyr Asp Pro Ser Pro Val
          35                  40                  45            
 Ser Pro Phe Ile Cys Tyr Tyr Asp Asp Lys Tyr Glu Ile Gln Glu Arg
      50                  55                  60                
 Glu Lys Arg Leu Lys Gln Lys Ile Lys Val Leu Lys Lys Asn Gly Val
  65                  70                  75                  80
 Ile Pro Glu Pro Ser Lys Leu Pro Tyr Ile Lys Ala Ala Asn Glu Asn
                  85                  90                  95    
 Pro His His Asp Ile Arg Lys Gly Arg Ala Ser Trp Lys Ser Asn Arg
             100                 105                 110        
 Trp Pro Gln Glu Asn Lys Glu Thr Gln Lys Glu Met Lys Asn Lys Asn
         115                 120                 125            
 Arg Asn Trp Glu Lys His Arg Lys Ala Asp Arg His Arg Glu Val Asp
     130                 135                 140                
 Glu Asp Phe Pro Arg Gly Pro Lys Thr Tyr Ser Ser Pro Gly Ser Phe
 145                 150                 155                 160
 Lys Thr Gln Lys Pro Ser Lys Pro Phe His Arg Ser Ser His Tyr His
                 165                 170                 175    
 Thr Ser Arg Glu Asp Lys Ser Pro Lys Glu Gly Lys Arg Gly Lys Gln
             180                 185                 190        
 Lys Lys Lys Glu Arg Cys Trp Glu Asp Asp Asp Asn Asp Asn Leu Phe
         195                 200                 205            
 Leu Ile Lys Gln Arg Lys Lys Lys Ser
     210                 215        



      <210> 332
      <211> 268
      <212> PRT
      <213> Homo sapiens


      <400> 332
 Met Asp Gly Leu Ser Pro Ser Gln Ser Met Lys Arg Gly Arg Asp Leu
   1               5                  10                  15    
 Gly Glu Ala Gln Leu Gln Leu Trp Val Glu Lys Thr Gly Leu Arg Thr
              20                  25                  30        
 Ile Ser Ser Met Ala Ser Phe Pro Leu Leu Leu Thr Leu Leu Thr His
          35                  40                  45            
 Cys Ala Gly Ser Trp Ala Gln Ser Val Leu Thr Gln Pro Pro Ser Ala
      50                  55                  60                
 Ser Gly Thr Pro Gly Gln Arg Val Thr Ile Ser Cys Ser Gly Ser Arg
  65                  70                  75                  80
 Ser Asn Val Gly Ser Asn Asn Val Asn Trp Tyr Gln Gln Leu Pro Gly
                  85                  90                  95    
 Thr Ala Pro Lys Leu Leu Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly
             100                 105                 110        
 Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu
         115                 120                 125            
 Ala Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala
     130                 135                 140                
 Thr Trp Asp Asp Ser Thr Val Val Phe Gly Gly Gly Thr Lys Leu Thr
 145                 150                 155                 160
 Val Pro Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro
                 165                 170                 175    
 Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile
             180                 185                 190        
 Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser
         195                 200                 205            
 Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser
     210                 215                 220                
 Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln
 225                 230                 235                 240
 Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser
                 245                 250                 255    
 Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser
             260                 265            



      <210> 333
      <211> 137
      <212> PRT
      <213> Homo sapiens


      <400> 333
 Met Gly Pro Arg Ser Ile Gln Glu Arg His Phe Lys Lys Val Gly Lys
   1               5                  10                  15    
 His Ser Thr Arg Lys Glu Gln Asp Ala Gln Ala Phe Val Asp Asn Ala
              20                  25                  30        
 Ala Lys Gly Lys Arg Leu Glu Gly Pro Ala Pro Arg Glu Leu Glu Gln
          35                  40                  45            
 Pro His Ile Val Gln Gly Pro Glu Lys Val Val Gly Asn Thr Ile Tyr
      50                  55                  60                
 Thr Lys Pro Ser Phe Thr Gln Glu His Lys Ala Ala Val Ser Ser Val
  65                  70                  75                  80
 Leu Lys Pro Phe Ser Met Gly Val Pro Ser Ala Ser Ser Pro Ala Lys
                  85                  90                  95    
 Ala Leu Pro Gln Val Arg Asp Arg Ser Lys Asp Leu Ala Tyr Thr Ile
             100                 105                 110        
 Leu Ile Leu Glu Met Ala Met Ala Arg Val Lys Asn Met Lys Ala Ala
         115                 120                 125            
 Lys Pro Ile Thr His Ser Arg Lys Lys
     130                 135        



      <210> 334
      <211> 1281
      <212> PRT
      <213> Homo sapiens


      <400> 334
 Met Asp Gly Pro Thr Arg Gly His Gly Leu Arg Lys Lys Arg Arg Ser
   1               5                  10                  15    
 Arg Ser Gln Arg Asp Arg Glu Arg Arg Ser Arg Gly Gly Leu Gly Ala
              20                  25                  30        
 Gly Ala Ala Gly Gly Gly Gly Ala Gly Arg Thr Arg Ala Leu Ser Leu
          35                  40                  45            
 Ala Ser Ser Ser Gly Ser Asp Lys Glu Asp Asn Gly Lys Pro Pro Ser
      50                  55                  60                
 Ser Ala Pro Ser Arg Pro Arg Pro Pro Arg Arg Lys Arg Arg Glu Ser
  65                  70                  75                  80
 Thr Ser Ala Glu Glu Asp Ile Ile Asp Gly Phe Ala Met Thr Ser Phe
                  85                  90                  95    
 Val Thr Phe Glu Ala Leu Glu Lys Asp Val Ala Leu Lys Pro Gln Glu
             100                 105                 110        
 Arg Val Glu Lys Arg Gln Thr Pro Leu Thr Lys Lys Lys Arg Glu Ala
         115                 120                 125            
 Leu Thr Asn Gly Leu Ser Phe His Ser Lys Lys Ser Arg Leu Ser His
     130                 135                 140                
 Pro His His Tyr Ser Ser Asp Arg Glu Asn Asp Arg Asn Leu Cys Gln
 145                 150                 155                 160
 His Leu Gly Lys Arg Lys Lys Met Pro Lys Ala Leu Arg Gln Leu Lys
                 165                 170                 175    
 Pro Gly Gln Asn Ser Cys Arg Asp Ser Asp Ser Glu Ser Ala Ser Gly
             180                 185                 190        
 Glu Ser Lys Gly Phe His Arg Ser Ser Ser Arg Glu Arg Leu Ser Asp
         195                 200                 205            
 Ser Ser Ala Pro Ser Ser Leu Gly Thr Gly Tyr Phe Cys Asp Ser Asp
     210                 215                 220                
 Ser Asp Gln Glu Glu Lys Ala Ser Asp Ala Ser Ser Glu Lys Leu Phe
 225                 230                 235                 240
 Asn Thr Val Ile Val Asn Lys Asp Pro Glu Leu Gly Val Gly Thr Leu
                 245                 250                 255    
 Pro Glu His Asp Ser Gln Asp Ala Gly Pro Ile Val Pro Lys Ile Ser
             260                 265                 270        
 Gly Leu Glu Arg Ser Gln Glu Lys Ser Gln Asp Cys Cys Lys Glu Pro
         275                 280                 285            
 Ile Phe Glu Pro Val Val Leu Lys Asp Pro Cys Pro Gln Val Ala Gln
     290                 295                 300                
 Pro Ile Pro Gln Pro Gln Thr Glu Pro Gln Leu Arg Ala Pro Ser Pro
 305                 310                 315                 320
 Asp Pro Asp Leu Val Gln Arg Thr Glu Ala Pro Pro Gln Pro Pro Pro
                 325                 330                 335    
 Leu Ser Thr Gln Pro Pro Gln Gly Pro Pro Glu Ala Gln Leu Gln Pro
             340                 345                 350        
 Ala Pro Gln Pro Gln Val Gln Arg Pro Pro Arg Pro Gln Ser Pro Thr
         355                 360                 365            
 Gln Leu Leu His Gln Asn Leu Pro Pro Val Gln Ala His Pro Ser Ala
     370                 375                 380                
 Gln Ser Leu Ser Gln Pro Leu Ser Ala Tyr Asn Ser Ser Ser Leu Ser
 385                 390                 395                 400
 Leu Asn Ser Leu Ser Ser Ser Arg Ser Ser Thr Pro Ala Lys Thr Gln
                 405                 410                 415    
 Pro Ala Pro Pro His Ile Ser His His Pro Ser Ala Ser Pro Phe Pro
             420                 425                 430        
 Leu Ser Leu Pro Asn His Ser Pro Leu His Ser Phe Thr Pro Thr Leu
         435                 440                 445            
 Gln Pro Pro Ala His Ser His His Pro Asn Met Phe Ala Pro Pro Thr
     450                 455                 460                
 Ala Leu Pro Pro Pro Pro Pro Leu Thr Ser Gly Ser Leu Gln Val Ala
 465                 470                 475                 480
 Gly His Pro Ala Gly Ser Thr Tyr Ser Glu Gln Asp Ile Leu Arg Gln
                 485                 490                 495    
 Glu Leu Asn Thr Arg Phe Leu Ala Ser Gln Ser Ala Asp Arg Gly Ala
             500                 505                 510        
 Ser Leu Gly Pro Pro Pro Tyr Leu Arg Thr Glu Phe His Gln His Gln
         515                 520                 525            
 His Gln His Gln His Thr His Gln His Thr His Gln His Thr Phe Thr
     530                 535                 540                
 Pro Phe Pro His Ala Ile Pro Pro Thr Ala Ile Met Pro Thr Pro Ala
 545                 550                 555                 560
 Pro Pro Met Phe Asp Lys Tyr Pro Thr Lys Val Asp Pro Phe Tyr Arg
                 565                 570                 575    
 His Ser Leu Phe His Ser Tyr Pro Pro Ala Val Ser Gly Ile Pro Pro
             580                 585                 590        
 Met Ile Pro Pro Thr Gly Pro Phe Gly Ser Leu Gln Gly Ala Phe Gln
         595                 600                 605            
 Pro Lys Thr Ser Asn Pro Ile Asp Val Ala Ala Arg Pro Gly Thr Val
     610                 615                 620                
 Pro His Thr Leu Leu Gln Lys Asp Pro Arg Leu Thr Asp Pro Phe Arg
 625                 630                 635                 640
 Pro Met Leu Arg Lys Pro Gly Lys Trp Cys Ala Met His Val His Ile
                 645                 650                 655    
 Ala Trp Gln Ile Tyr His His Gln Gln Lys Val Lys Lys Gln Met Gln
             660                 665                 670        
 Ser Asp Pro His Lys Leu Asp Phe Gly Leu Lys Pro Glu Phe Leu Ser
         675                 680                 685            
 Arg Pro Pro Gly Pro Ser Leu Phe Gly Ala Ile His His Pro His Asp
     690                 695                 700                
 Leu Ala Arg Pro Ser Thr Leu Phe Ser Ala Ala Gly Ala Ala His Pro
 705                 710                 715                 720
 Thr Gly Thr Pro Phe Gly Pro Pro Pro His His Ser Asn Phe Leu Asn
                 725                 730                 735    
 Pro Ala Ala His Leu Glu Pro Phe Asn Arg Pro Ser Thr Phe Thr Gly
             740                 745                 750        
 Leu Ala Ala Val Gly Gly Asn Ala Phe Gly Gly Leu Gly Asn Pro Ser
         755                 760                 765            
 Val Thr Pro Asn Ser Met Phe Gly His Lys Asp Gly Pro Ser Val Gln
     770                 775                 780                
 Asn Phe Ser Asn Pro His Glu Pro Trp Asn Arg Leu His Arg Thr Pro
 785                 790                 795                 800
 Pro Ser Phe Pro Thr Pro Pro Pro Trp Leu Lys Pro Gly Glu Leu Glu
                 805                 810                 815    
 Arg Ser Ala Ser Ala Ala Ala His Asp Arg Asp Arg Asp Val Asp Lys
             820                 825                 830        
 Arg Asp Ser Ser Val Ser Lys Asp Asp Lys Glu Arg Glu Ser Val Glu
         835                 840                 845            
 Lys Arg His Ser Ser His Pro Ser Pro Ala Pro Val Leu Pro Val Asn
     850                 855                 860                
 Ala Leu Gly His Thr Arg Ser Ser Thr Glu Gln Ile Arg Ala His Leu
 865                 870                 875                 880
 Asn Thr Glu Ala Arg Glu Lys Asp Lys Pro Lys Glu Arg Glu Arg Asp
                 885                 890                 895    
 His Ser Glu Ser Arg Lys Asp Leu Ala Ala Asp Glu His Lys Ala Lys
             900                 905                 910        
 Glu Gly His Leu Pro Glu Lys Asp Gly His Gly His Glu Gly Arg Ala
         915                 920                 925            
 Ala Gly Glu Glu Ala Lys Gln Leu Ala Arg Val Pro Ser Pro Tyr Val
     930                 935                 940                
 Arg Thr Pro Val Val Glu Ser Ala Arg Pro Asn Ser Thr Ser Ser Pro
 945                 950                 955                 960
 Gly Gly Pro Ser Pro Arg Lys Gly Glu Pro Ala Tyr Glu Asn Pro Lys
                 965                 970                 975    
 Lys Ser Ser Glu Val Lys Val Lys Glu Glu Arg Lys Glu Asp His Asp
             980                 985                 990        
 Leu Pro Pro Glu Ala Pro Gln Thr His Arg Ala Ser Glu Pro Pro Pro
         995                1000                1005            
 Pro Asn Ser Ser Ser Ser Val His Pro Gly Pro Leu Ala Ser Met Pro
    1010                1015                1020                
 Met Thr Val Gly Val Thr Gly Ile His Pro Met Asn Ser Ile Ser Ser
1025                1030                1035                1040
 Leu Asp Arg Thr Arg Met Met Thr Pro Phe Met Gly Ile Ser Pro Leu
                1045                1050                1055    
 Pro Gly Gly Glu Arg Phe Pro Tyr Pro Ser Phe His Trp Asp Pro Ile
            1060                1065                1070        
 Arg Asp Pro Leu Arg Asp Pro Tyr Arg Glu Leu Asp Ile His Arg Arg
        1075                1080                1085            
 Asp Pro Leu Gly Arg Asp Phe Leu Leu Arg Asn Asp Pro Leu His Arg
    1090                1095                1100                
 Leu Ser Thr Pro Arg Leu Tyr Glu Ala Asp Arg Ser Phe Arg Asp Arg
1105                1110                1115                1120
 Glu Pro His Asp Tyr Ser His His His His His His His His Pro Leu
                1125                1130                1135    
 Ser Val Asp Pro Arg Arg Glu His Glu Arg Gly Gly His Leu Asp Glu
            1140                1145                1150        
 Arg Glu Arg Leu His Met Leu Arg Glu Asp Tyr Glu His Thr Arg Leu
        1155                1160                1165            
 His Ser Val His Pro Ala Ser Leu Asp Gly His Leu Pro His Pro Ser
    1170                1175                1180                
 Leu Ile Thr Pro Gly Leu Pro Ser Met His Tyr Pro Arg Ile Ser Pro
1185                1190                1195                1200
 Thr Ala Gly Asn Gln Asn Gly Leu Leu Asn Lys Thr Pro Pro Thr Ala
                1205                1210                1215    
 Ala Leu Ser Ala Pro Pro Pro Leu Ile Ser Thr Leu Gly Gly Arg Pro
            1220                1225                1230        
 Val Ser Pro Arg Arg Thr Thr Pro Leu Ser Ala Glu Ile Arg Gly Glu
        1235                1240                1245            
 Ala Pro Phe Pro His Ala Glu Gly Tyr Arg Gly Pro Ile Ser Arg Glu
    1250                1255                1260                
 Gln Glu Gln Glu Arg Gly Arg Arg Asn Pro Arg Gln Thr Pro Gly Gln
1265                1270                1275                1280
 Ala
    



      <210> 335
      <211> 133
      <212> PRT
      <213> Homo sapiens


      <400> 335
 Met Gln Ser Ile Leu Gly Val Ser Phe His Arg Lys Ala Phe Ser Cys
   1               5                  10                  15    
 Ser Leu Gly Ser Pro His Ser Pro Thr Ser Val Cys Pro Leu Gly Gly
              20                  25                  30        
 Val Thr Gln Gly Leu Ile Leu Thr Arg Pro Ser Lys Arg His Gly Ser
          35                  40                  45            
 Cys Gly Asn Ile Arg Ser Pro His Ser Thr Thr Gln Asp Gln Glu Asn
      50                  55                  60                
 Ile Gly Glu Cys Ala Glu Asp Thr Ile Pro Phe Glu Val Ser Lys Gly
  65                  70                  75                  80
 Glu Pro Gln Pro Lys Asp Asn Leu Ile Arg Ser Leu Phe Leu Gly Gln
                  85                  90                  95    
 Val Gly Tyr Leu Met Pro Val Ile Pro Ala Leu Trp Glu Thr Lys Ala
             100                 105                 110        
 Gly Gly Ser Arg Gly Gln Glu Ile Glu Ser Ile Leu Ala Asn Met Val
         115                 120                 125            
 Lys Ser Cys Leu Tyr
     130            



      <210> 336
      <211> 796
      <212> PRT
      <213> Homo sapiens


      <400> 336
 Met Met Gly Leu Thr Asp Asp Arg Asp Ile Ser Glu Thr Val Ser Glu
   1               5                  10                  15    
 Thr Trp Ser Thr Asp Val Leu Gly Ser Asp Phe Asp Pro Asn Ile Asp
              20                  25                  30        
 Glu Asp Arg Leu Gln Glu Ile Ala Gly Ala Ala Ala Glu Asn Met Leu
          35                  40                  45            
 Gly Ser Leu Leu Cys Leu Pro Gly Ser Gly Ser Val Leu Leu Asp Pro
      50                  55                  60                
 Cys Thr Gly Ser Thr Ile Ser Glu Thr Thr Ser Glu Ala Trp Ser Val
  65                  70                  75                  80
 Glu Val Leu Pro Ser Asp Ser Glu Ala Pro Asp Leu Lys Gln Glu Glu
                  85                  90                  95    
 Arg Leu Gln Glu Leu Glu Ser Cys Ser Gly Leu Gly Ser Thr Ser Asp
             100                 105                 110        
 Asp Thr Asp Val Arg Glu Val Ser Ser Arg Pro Ser Thr Pro Gly Leu
         115                 120                 125            
 Ser Val Val Ser Gly Ile Ser Ala Thr Ser Glu Asp Ile Pro Asn Lys
     130                 135                 140                
 Ile Glu Asp Leu Arg Ser Glu Cys Ser Ser Asp Phe Gly Gly Lys Asp
 145                 150                 155                 160
 Ser Val Thr Ser Pro Asp Met Asp Glu Ile Thr His Gly Ala His Gln
                 165                 170                 175    
 Leu Thr Ser Pro Pro Ser Gln Ser Glu Ser Leu Leu Ala Met Phe Asp
             180                 185                 190        
 Pro Leu Ser Ser His Glu Gly Ala Ser Ala Val Val Arg Pro Lys Val
         195                 200                 205            
 His Tyr Ala Arg Pro Ser His Pro Pro Pro Asp Pro Pro Ile Leu Glu
     210                 215                 220                
 Gly Ala Val Gly Gly Asn Glu Ala Arg Leu Pro Asn Phe Gly Ser His
 225                 230                 235                 240
 Val Leu Thr Pro Ala Glu Met Glu Ala Phe Lys Gln Arg His Ser Tyr
                 245                 250                 255    
 Pro Glu Arg Leu Val Arg Ser Arg Ser Ser Asp Ile Val Ser Ser Val
             260                 265                 270        
 Arg Arg Pro Met Ser Asp Pro Ser Trp Asn Arg Arg Pro Gly Asn Glu
         275                 280                 285            
 Glu Arg Glu Leu Pro Pro Ala Ala Ala Ile Gly Ala Thr Ser Leu Val
     290                 295                 300                
 Ala Ala Pro His Ser Ser Ser Ser Ser Pro Ser Lys Asp Ser Ser Arg
 305                 310                 315                 320
 Gly Glu Thr Glu Glu Arg Lys Asp Ser Asp Asp Glu Lys Ser Asp Arg
                 325                 330                 335    
 Asn Arg Pro Trp Trp Arg Lys Arg Phe Val Ser Ala Met Pro Lys Asp
             340                 345                 350        
 Asp Pro Ser Pro Arg Leu Ser Ala Gln Ala Gln Val Ala Glu Asp Ile
         355                 360                 365            
 Leu Asp Lys Tyr Arg Asn Ala Ile Lys Arg Thr Ser Pro Ser Asp Gly
     370                 375                 380                
 Ala Met Ala Asn Tyr Glu Ser Thr Glu Val Met Gly Asp Gly Glu Ser
 385                 390                 395                 400
 Ala His Asp Ser Pro Arg Asp Glu Ala Leu Gln Asn Ile Ser Ala Asp
                 405                 410                 415    
 Asp Leu Pro Asp Ser Ala Ser Gln Ala Ala His Pro Gln Asp Ser Ala
             420                 425                 430        
 Phe Ser Tyr Arg Asp Ala Lys Lys Lys Leu Arg Leu Ala Leu Cys Ser
         435                 440                 445            
 Ala Asp Ser Val Ala Phe Pro Val Leu Thr His Ser Thr Arg Asn Gly
     450                 455                 460                
 Leu Pro Asp His Thr Asp Pro Glu Asp Asn Glu Ile Val Cys Phe Leu
 465                 470                 475                 480
 Lys Val Gln Ile Ala Glu Ala Ile Asn Leu Gln Asp Lys Asn Leu Met
                 485                 490                 495    
 Ala Gln Leu Gln Glu Thr Met Arg Cys Val Cys Arg Phe Asp Asn Arg
             500                 505                 510        
 Thr Cys Arg Lys Leu Leu Ala Ser Ile Ala Glu Asp Tyr Arg Lys Arg
         515                 520                 525            
 Ala Pro Tyr Ile Ala Tyr Leu Thr Arg Cys Arg Gln Gly Leu Gln Thr
     530                 535                 540                
 Thr Gln Ala His Leu Glu Arg Leu Leu Gln Arg Val Leu Arg Asp Lys
 545                 550                 555                 560
 Glu Val Ala Asn Arg Tyr Phe Thr Thr Val Cys Val Arg Leu Leu Leu
                 565                 570                 575    
 Glu Ser Lys Glu Lys Lys Ile Arg Glu Phe Ile Gln Asp Phe Gln Lys
             580                 585                 590        
 Leu Thr Ala Ala Asp Asp Lys Thr Ala Gln Val Glu Asp Phe Leu Gln
         595                 600                 605            
 Phe Leu Tyr Gly Ala Met Ala Gln Asp Val Ile Trp Gln Asn Ala Ser
     610                 615                 620                
 Glu Glu Gln Leu Gln Asp Ala Gln Leu Ala Ile Glu Arg Ser Val Met
 625                 630                 635                 640
 Asn Arg Ile Phe Lys Leu Ala Phe Tyr Pro Asn Gln Asp Gly Asp Ile
                 645                 650                 655    
 Leu Arg Asp Gln Val Leu His Glu His Ile Gln Arg Leu Ser Lys Val
             660                 665                 670        
 Val Thr Ala Asn His Arg Ala Leu Gln Ile Pro Glu Val Tyr Leu Arg
         675                 680                 685            
 Glu Ala Pro Trp Pro Ser Ala Gln Ser Glu Ile Arg Thr Ile Ser Ala
     690                 695                 700                
 Tyr Lys Thr Pro Arg Asp Lys Val Gln Cys Ile Leu Arg Met Cys Ser
 705                 710                 715                 720
 Thr Ile Met Asn Leu Leu Ser Leu Ala Asn Glu Asp Ser Val Pro Gly
                 725                 730                 735    
 Ala Asp Asp Phe Val Pro Val Leu Val Phe Val Leu Ile Lys Ala Asn
             740                 745                 750        
 Pro Pro Cys Leu Leu Ser Thr Val Gln Tyr Ile Ser Ser Phe Tyr Ala
         755                 760                 765            
 Ser Cys Leu Ser Gly Glu Glu Ser Tyr Trp Trp Met Gln Phe Thr Ala
     770                 775                 780                
 Ala Val Glu Phe Ile Lys Thr Ile Asp Asp Arg Lys
 785                 790                 795    



      <210> 337
      <211> 334
      <212> PRT
      <213> Homo sapiens


      <400> 337
 Met Asp Asn Ser Ala Gln Lys Asn Glu Arg Thr Gly Lys His Pro Arg
   1               5                  10                  15    
 Arg Ala Ser Glu Val Gln Lys Gly Phe Thr Ala Ala Tyr Pro Thr Gln
              20                  25                  30        
 Ser Ser Ile Pro Phe Lys Ser Gln Ala Ser Val Ile Pro Glu Ser Glu
          35                  40                  45            
 Lys Lys Gly Phe Asn Ser Gln Ala Lys Arg Phe Pro His Lys Lys Asn
      50                  55                  60                
 Asp Ile Pro Gly Pro Gly Phe Tyr Asn Val Ile His Gln Ser Pro Val
  65                  70                  75                  80
 Ser Asn Ser Val Ser Leu Ser Lys Lys Gly Thr Cys Met Phe Pro Ser
                  85                  90                  95    
 Met Cys Ala Arg Leu Asp Thr Ile Ile Ser Lys Tyr Pro Ala Ala Asn
             100                 105                 110        
 Ala Tyr Thr Ile Pro Ser Asp Phe Ile Ser Lys Arg Asp Phe Ser Asn
         115                 120                 125            
 Ser Cys Ser Ser Met Phe Gln Leu Pro Ser Phe Met Lys Ala Leu Lys
     130                 135                 140                
 Phe Glu Thr Pro Ala Pro Asn Tyr Tyr Asn Ala Ser Val Ser Cys Cys
 145                 150                 155                 160
 Lys Gln Arg Asn Asn Val Cys Thr Arg Ala Gly Phe Met Ser Lys Thr
                 165                 170                 175    
 Gln Arg Gly Ser Phe Ala Phe Ala Asp Lys Gly Pro Pro Pro Gly His
             180                 185                 190        
 Tyr Asp Ile Asn Glu Ser Leu Val Lys Gln Ser Pro Asn Thr Leu Met
         195                 200                 205            
 Ser Cys Phe Lys Ser Lys Thr Asn Arg Gly Leu Lys Leu Thr Ser Thr
     210                 215                 220                
 Gly Pro Gly Pro Gly Tyr Tyr Asn Pro Ser Asp Cys Thr Lys Val Pro
 225                 230                 235                 240
 Lys Lys Thr Leu Phe Pro Lys Asn Pro Ile Leu Asn Phe Ser Ala Gln
                 245                 250                 255    
 Pro Ser Pro Leu Pro Pro Lys Pro Pro Phe Pro Gly Pro Gly Gln Tyr
             260                 265                 270        
 Glu Ile Val Asp Tyr Leu Gly Pro Arg Lys His Phe Ile Ser Ser Ala
         275                 280                 285            
 Ser Phe Val Ser Asn Thr Ser Arg Trp Thr Ala Ala Pro Pro Gln Pro
     290                 295                 300                
 Gly Leu Pro Gly Pro Ala Thr Tyr Lys Pro Glu Leu Pro Gly Lys Gln
 305                 310                 315                 320
 Ser Phe Leu Tyr Asn Glu Asp Lys Lys Trp Ile Pro Val Leu
                 325                 330                



      <210> 338
      <211> 323
      <212> PRT
      <213> Homo sapiens


      <400> 338
 Met Trp Pro Leu Val Ala Ala Leu Leu Leu Gly Ser Ala Cys Cys Gly
   1               5                  10                  15    
 Ser Ala Gln Leu Leu Phe Asn Lys Thr Lys Ser Val Glu Phe Thr Phe
              20                  25                  30        
 Cys Asn Asp Thr Val Val Ile Pro Cys Phe Val Thr Asn Met Glu Ala
          35                  40                  45            
 Gln Asn Thr Thr Glu Val Tyr Val Lys Trp Lys Phe Lys Gly Arg Asp
      50                  55                  60                
 Ile Tyr Thr Phe Asp Gly Ala Leu Asn Lys Ser Thr Val Pro Thr Asp
  65                  70                  75                  80
 Phe Ser Ser Ala Lys Ile Glu Val Ser Gln Leu Leu Lys Gly Asp Ala
                  85                  90                  95    
 Ser Leu Lys Met Asp Lys Ser Asp Ala Val Ser His Thr Gly Asn Tyr
             100                 105                 110        
 Thr Cys Glu Val Thr Glu Leu Thr Arg Glu Gly Glu Thr Ile Ile Glu
         115                 120                 125            
 Leu Lys Tyr Arg Val Val Ser Trp Phe Ser Pro Asn Glu Asn Ile Leu
     130                 135                 140                
 Ile Val Ile Phe Pro Ile Phe Ala Ile Leu Leu Phe Trp Gly Gln Phe
 145                 150                 155                 160
 Gly Ile Lys Thr Leu Lys Tyr Arg Ser Gly Gly Met Asp Glu Lys Thr
                 165                 170                 175    
 Ile Ala Leu Leu Val Ala Gly Leu Val Ile Thr Val Ile Val Ile Val
             180                 185                 190        
 Gly Ala Ile Leu Phe Val Pro Gly Glu Tyr Ser Leu Lys Asn Ala Thr
         195                 200                 205            
 Gly Leu Gly Leu Ile Val Thr Ser Thr Gly Ile Leu Ile Leu Leu His
     210                 215                 220                
 Tyr Tyr Val Phe Ser Thr Ala Ile Gly Leu Thr Ser Phe Val Ile Ala
 225                 230                 235                 240
 Ile Leu Val Ile Gln Val Ile Ala Tyr Ile Leu Ala Val Val Gly Leu
                 245                 250                 255    
 Ser Leu Cys Ile Ala Ala Cys Ile Pro Met His Gly Pro Leu Leu Ile
             260                 265                 270        
 Ser Gly Leu Ser Ile Leu Ala Leu Ala Gln Leu Leu Gly Leu Val Tyr
         275                 280                 285            
 Met Lys Phe Val Ala Ser Asn Gln Lys Thr Ile Gln Pro Pro Arg Lys
     290                 295                 300                
 Ala Val Glu Glu Pro Leu Asn Ala Phe Lys Glu Ser Lys Gly Met Met
 305                 310                 315                 320
 Asn Asp Glu
            



      <210> 339
      <211> 670
      <212> PRT
      <213> Homo sapiens


      <400> 339
 Met Val Lys Lys Arg Lys Gly Arg Val Val Ile Asp Ser Asp Thr Glu
   1               5                  10                  15    
 Asp Ser Gly Ser Asp Glu Asn Leu Asp Gln Glu Leu Leu Ser Leu Ala
              20                  25                  30        
 Lys Arg Lys Arg Ser Asp Ser Glu Glu Lys Glu Pro Pro Val Ser Gln
          35                  40                  45            
 Pro Ala Ala Ser Ser Asp Ser Glu Thr Ser Asp Ser Asp Asp Glu Trp
      50                  55                  60                
 Thr Phe Gly Ser Asn Lys Asn Lys Lys Lys Gly Lys Ala Arg Lys Ile
  65                  70                  75                  80
 Glu Lys Lys Gly Thr Met Lys Lys Gln Ala Asn Lys Thr Ala Ser Ser
                  85                  90                  95    
 Gly Ser Ser Asp Lys Asp Ser Ser Ala Glu Ser Ser Ala Pro Glu Glu
             100                 105                 110        
 Gly Glu Val Ser Asp Ser Asp Ser Asn Ser Ser Ser Ser Ser Ser Asp
         115                 120                 125            
 Ser Asp Ser Ser Ser Glu Asp Glu Glu Phe His Asp Gly Tyr Gly Glu
     130                 135                 140                
 Asp Leu Met Gly Asp Glu Glu Asp Arg Ala Arg Leu Glu Gln Met Thr
 145                 150                 155                 160
 Glu Lys Glu Arg Glu Gln Glu Leu Phe Asn Arg Ile Glu Lys Arg Glu
                 165                 170                 175    
 Val Leu Lys Arg Arg Phe Glu Ile Lys Lys Lys Leu Lys Thr Ala Lys
             180                 185                 190        
 Lys Lys Glu Lys Lys Glu Lys Lys Lys Lys Gln Glu Glu Glu Gln Glu
         195                 200                 205            
 Lys Lys Lys Leu Thr Gln Ile Gln Glu Ser Gln Val Thr Ser His Asn
     210                 215                 220                
 Lys Glu Arg Arg Ser Lys Arg Asp Glu Lys Leu Asp Lys Lys Ser Gln
 225                 230                 235                 240
 Ala Met Glu Glu Leu Lys Ala Glu Arg Glu Lys Arg Lys Asn Arg Thr
                 245                 250                 255    
 Ala Glu Leu Leu Ala Lys Lys Gln Pro Leu Lys Thr Ser Glu Val Tyr
             260                 265                 270        
 Ser Asp Asp Glu Glu Glu Glu Glu Asp Asp Lys Ser Ser Glu Lys Ser
         275                 280                 285            
 Asp Arg Ser Ser Arg Thr Ser Ser Ser Asp Glu Glu Glu Glu Lys Glu
     290                 295                 300                
 Glu Ile Pro Pro Lys Ser Gln Pro Val Ser Leu Pro Glu Glu Leu Asn
 305                 310                 315                 320
 Arg Val Arg Leu Ser Arg His Lys Leu Glu Arg Trp Cys His Met Pro
                 325                 330                 335    
 Phe Phe Ala Lys Thr Val Thr Gly Cys Phe Val Arg Ile Gly Ile Gly
             340                 345                 350        
 Asn His Asn Ser Lys Pro Val Tyr Arg Val Ala Glu Ile Thr Gly Val
         355                 360                 365            
 Val Glu Thr Ala Lys Val Tyr Gln Leu Gly Gly Thr Arg Thr Asn Lys
     370                 375                 380                
 Gly Leu Gln Leu Arg His Gly Asn Asp Gln Arg Val Phe Arg Leu Glu
 385                 390                 395                 400
 Phe Val Ser Asn Gln Glu Phe Thr Glu Ser Glu Phe Met Lys Trp Lys
                 405                 410                 415    
 Glu Ala Met Phe Ser Ala Gly Met Gln Leu Pro Thr Leu Asp Glu Ile
             420                 425                 430        
 Asn Lys Lys Glu Leu Ser Ile Lys Glu Ala Leu Asn Tyr Lys Phe Asn
         435                 440                 445            
 Asp Gln Asp Ile Glu Glu Ile Val Lys Glu Lys Glu Arg Phe Arg Lys
     450                 455                 460                
 Ala Pro Pro Asn Tyr Ala Met Lys Lys Thr Gln Leu Leu Lys Glu Lys
 465                 470                 475                 480
 Ala Met Ala Glu Asp Leu Gly Asp Gln Asp Lys Ala Lys Gln Ile Gln
                 485                 490                 495    
 Asp Gln Leu Asn Glu Leu Glu Glu Arg Ala Glu Ala Leu Asp Arg Gln
             500                 505                 510        
 Arg Thr Lys Asn Ile Ser Ala Ile Ser Tyr Ile Asn Gln Arg Asn Arg
         515                 520                 525            
 Glu Trp Asn Ile Val Glu Ser Glu Lys Ala Leu Val Ala Glu Ser His
     530                 535                 540                
 Asn Met Lys Asn Gln Gln Met Asp Pro Phe Thr Arg Arg Gln Cys Lys
 545                 550                 555                 560
 Pro Thr Ile Val Ser Asn Ser Arg Asp Pro Ala Val Gln Ala Ala Ile
                 565                 570                 575    
 Leu Ala Gln Leu Asn Ala Lys Tyr Gly Ser Gly Val Leu Pro Asp Ala
             580                 585                 590        
 Pro Lys Glu Met Ser Lys Gly Gln Gly Lys Asp Lys Asp Leu Asn Ser
         595                 600                 605            
 Lys Ser Ala Ser Asp Leu Ser Glu Asp Leu Phe Lys Val His Asp Phe
     610                 615                 620                
 Asp Val Lys Ile Asp Leu Gln Val Pro Ser Ser Glu Ser Lys Ala Leu
 625                 630                 635                 640
 Ala Ile Thr Ser Lys Ala Pro Pro Ala Lys Asp Gly Ala Pro Arg Arg
                 645                 650                 655    
 Ser Leu Asn Leu Glu Asp Tyr Lys Lys Arg Arg Gly Leu Ile
             660                 665                 670



      <210> 340
      <211> 258
      <212> PRT
      <213> Homo sapiens


      <400> 340
 Met Tyr Tyr Phe Leu Cys His Leu Ala Leu Val Asp Ala Gly Phe Thr
   1               5                  10                  15    
 Thr Ser Val Val Pro Pro Leu Leu Ala Asn Leu Arg Gly Pro Ala Leu
              20                  25                  30        
 Trp Leu Pro Arg Ser His Cys Thr Ala Gln Leu Cys Ala Ser Leu Ala
          35                  40                  45            
 Leu Gly Ser Ala Glu Cys Val Leu Leu Ala Val Met Ala Leu Asp Arg
      50                  55                  60                
 Ala Ala Ala Val Cys Arg Pro Leu Arg Tyr Ala Gly Leu Val Ser Pro
  65                  70                  75                  80
 Arg Leu Cys Arg Thr Leu Ala Ser Ala Ser Trp Leu Ser Gly Leu Thr
                  85                  90                  95    
 Asn Ser Val Ala Gln Thr Ala Leu Leu Ala Glu Arg Pro Leu Cys Ala
             100                 105                 110        
 Pro Arg Leu Leu Asp His Phe Ile Cys Glu Leu Pro Ala Leu Leu Lys
         115                 120                 125            
 Leu Ala Cys Gly Gly Asp Gly Asp Thr Thr Glu Asn Gln Met Phe Ala
     130                 135                 140                
 Ala Arg Val Val Ile Leu Leu Leu Pro Phe Ala Val Ile Leu Ala Ser
 145                 150                 155                 160
 Tyr Gly Ala Val Ala Arg Ala Val Cys Cys Met Arg Phe Ser Gly Gly
                 165                 170                 175    
 Arg Arg Arg Ala Val Gly Thr Cys Gly Ser His Leu Thr Ala Val Cys
             180                 185                 190        
 Leu Phe Tyr Gly Ser Ala Ile Tyr Thr Tyr Leu Gln Pro Ala Gln Arg
         195                 200                 205            
 Tyr Asn Gln Ala Arg Gly Lys Phe Val Ser Leu Phe Tyr Thr Val Val
     210                 215                 220                
 Thr Pro Ala Leu Asn Pro Leu Ile Tyr Thr Leu Arg Asn Lys Lys Val
 225                 230                 235                 240
 Lys Gly Ala Ala Arg Arg Leu Leu Arg Ser Leu Gly Arg Gly Gln Ala
                 245                 250                 255    
 Gly Gln
        



      <210> 341
      <211> 105
      <212> PRT
      <213> Homo sapiens


      <400> 341
 Met Ala His Cys Ser Leu Asp Leu Ser Gly Ser Gly Asp Pro Pro Thr
   1               5                  10                  15    
 Ser Thr Ser Gln Val Ala Arg Thr Ile Gly Ala Cys His His Val Gln
              20                  25                  30        
 Leu Ile Phe Val Phe Phe Gly Glu Thr Gly Phe His His Val Ala Pro
          35                  40                  45            
 Leu Val Leu Glu Leu Leu Asp Ser Ser Asp Pro Pro Thr Leu Ala Ser
      50                  55                  60                
 Gln Ser Gly Gly Asn Arg His Glu Pro Pro His Arg Ala Leu Lys His
  65                  70                  75                  80
 Ile Phe Leu Lys His Ile Trp Leu Phe Ser Phe Tyr Phe His Gln Asn
                  85                  90                  95    
 Gly His Glu Glu Thr Met Asp Gln Ile
             100                 105



      <210> 342
      <211> 404
      <212> PRT
      <213> Homo sapiens


      <400> 342
 Met Val Pro Phe Ser Leu Gly Glu Val Met Thr Val Pro Arg Ala Gly
   1               5                  10                  15    
 Gly Pro Arg Glu Glu Arg Asp Lys Gln Lys Asp Thr Arg Glu Glu His
              20                  25                  30        
 His Ala Ser Asp Gln Arg Gln Pro Gln Pro Leu Arg Ser Arg Arg Ile
          35                  40                  45            
 Arg Arg Arg Arg His Thr Phe Pro Gly Leu Leu Arg Asp His Thr Leu
      50                  55                  60                
 Gly Val Ser Arg Asp Leu Thr Phe Leu Gly Gly Ala Gly Asn Glu Thr
  65                  70                  75                  80
 Asp Arg Gly Asn Ser Thr Arg Ala Gly Arg Trp Ser Gly Asp Phe Ala
                  85                  90                  95    
 Ala Pro Pro Thr Ser Leu Trp Ala Val Arg Leu Ala His Ala Gln Ala
             100                 105                 110        
 Ala Val Ala Arg Leu Arg Phe Ala Pro Ala Ala Gly Ala Met Gly Leu
         115                 120                 125            
 Ser Arg Val Arg Ala Val Phe Phe Asp Leu Asp Asn Thr Leu Ile Asp
     130                 135                 140                
 Thr Ala Gly Ala Ser Arg Arg Gly Met Leu Glu Val Ile Lys Leu Leu
 145                 150                 155                 160
 Gln Ser Lys Tyr His Tyr Lys Glu Glu Ala Glu Ile Ile Cys Asp Lys
                 165                 170                 175    
 Val Gln Val Lys Leu Ser Lys Glu Cys Phe His Pro Tyr Asn Thr Cys
             180                 185                 190        
 Ile Thr Asp Leu Arg Thr Ser His Trp Glu Glu Ala Ile Gln Glu Thr
         195                 200                 205            
 Lys Gly Gly Ala Ala Asn Arg Lys Leu Ala Glu Glu Cys Tyr Phe Leu
     210                 215                 220                
 Trp Lys Ser Thr Arg Leu Gln His Met Thr Leu Ala Glu Asp Val Lys
 225                 230                 235                 240
 Ala Met Leu Thr Glu Leu Arg Lys Glu Val Arg Leu Leu Leu Leu Thr
                 245                 250                 255    
 Asn Gly Asp Arg Gln Thr Gln Arg Glu Lys Ile Glu Ala Cys Ala Cys
             260                 265                 270        
 Gln Ser Tyr Phe Asp Ala Val Val Val Gly Gly Glu Gln Arg Glu Glu
         275                 280                 285            
 Lys Pro Ala Pro Ser Ile Phe Tyr Tyr Cys Cys Asn Leu Leu Gly Val
     290                 295                 300                
 Gln Pro Gly Asp Cys Val Met Val Gly Asp Thr Leu Glu Thr Asp Ile
 305                 310                 315                 320
 Gln Gly Gly Leu Asn Ala Gly Leu Lys Ala Thr Val Trp Ile Asn Lys
                 325                 330                 335    
 Asn Gly Ile Val Pro Leu Lys Ser Ser Pro Val Pro His Tyr Met Val
             340                 345                 350        
 Ser Ser Val Leu Glu Leu Pro Ala Leu Leu Gln Ser Ile Asp Cys Lys
         355                 360                 365            
 Val Arg Pro Gln His Leu Gly Met Pro Val Pro Ala Ser Leu Glu Glu
     370                 375                 380                
 Ser Ala Val Tyr Leu Ile Ile Ser Gln Pro Ser Pro Leu Leu Val Arg
 385                 390                 395                 400
 Thr Arg Phe Leu
                



      <210> 343
      <211> 358
      <212> PRT
      <213> Homo sapiens


      <400> 343
 Met Ser Ser Leu Gly Cys Trp Cys Gly Val Glu Asp Glu Ala Ala Pro
   1               5                  10                  15    
 Ser Lys Gln Ser Ile Tyr Ile Gln Arg Glu Thr Gln Val Arg Thr Pro
              20                  25                  30        
 Met Ala Gly Val Ser Pro Lys Lys Ala His Pro Cys Glu Met Cys Gly
          35                  40                  45            
 Pro Ile Leu Gly Asp Ile Leu His Val Ala Asp His Gln Gly Thr His
      50                  55                  60                
 His Lys Gln Lys Leu His Arg Cys Glu Ala Trp Gly Asn Lys Leu Tyr
  65                  70                  75                  80
 Asp Ser Gly Asn Phe His Gln His Gln Asn Glu His Ile Gly Glu Lys
                  85                  90                  95    
 Pro Tyr Arg Gly Ser Val Glu Glu Ala Leu Phe Ala Lys Arg Cys Lys
             100                 105                 110        
 Leu His Val Ser Gly Glu Ser Ser Val Phe Ser Glu Ser Gly Lys Asp
         115                 120                 125            
 Phe Leu Leu Arg Ser Gly Leu Leu Gln Gln Glu Ala Thr His Thr Gly
     130                 135                 140                
 Lys Ser Asn Ser Lys Thr Glu Cys Val Ser Leu Phe His Gly Gly Lys
 145                 150                 155                 160
 Ser His Tyr Ser Cys Gly Gly Cys Met Lys His Phe Ser Thr Lys Asp
                 165                 170                 175    
 Ile Leu Ser Gln His Glu Arg Leu Leu Pro Thr Glu Glu Pro Ser Val
             180                 185                 190        
 Trp Cys Glu Cys Gly Lys Ser Ser Ser Lys Tyr Asp Ser Phe Ser Asn
         195                 200                 205            
 His Gln Gly Val His Thr Arg Glu Lys Pro Tyr Thr Cys Gly Ile Cys
     210                 215                 220                
 Gly Lys Leu Phe Asn Ser Lys Ser His Leu Leu Val His Gln Arg Ile
 225                 230                 235                 240
 His Thr Gly Glu Lys Pro Tyr Glu Cys Glu Val Cys Gln Lys Phe Phe
                 245                 250                 255    
 Arg His Lys Tyr His Leu Ile Ala His Gln Arg Val His Thr Gly Glu
             260                 265                 270        
 Arg Pro Tyr Glu Cys Ser Asp Cys Gly Lys Ser Phe Thr His Ser Ser
         275                 280                 285            
 Thr Phe Arg Val His Lys Arg Val His Thr Gly Gln Lys Pro Tyr Glu
     290                 295                 300                
 Cys Ser Glu Cys Gly Lys Ser Phe Ala Glu Ser Ser Ser Leu Thr Lys
 305                 310                 315                 320
 His Arg Arg Val His Thr Gly Glu Lys Pro Tyr Gly Cys Ser Glu Cys
                 325                 330                 335    
 Glu Lys Lys Phe Arg Gln Ile Ser Ser Leu Arg His His Gln Arg Val
             340                 345                 350        
 His Lys Arg Lys Gly Leu
         355            



      <210> 344
      <211> 190
      <212> PRT
      <213> Homo sapiens


      <400> 344
 Met Met Met Ser Asp Asn Ala Lys Gly Arg Ala Ala His Ser Trp Lys
   1               5                  10                  15    
 Lys Arg Gly Ser Ile Ser Ser Leu Ser Asn His Glu Phe Trp Arg Lys
              20                  25                  30        
 Glu Ile His Gly Arg Ile Lys Asp Ser Met Ser Thr Val Ser Tyr Met
          35                  40                  45            
 Glu Glu Pro Ser Gln Arg Asp Asp Ile Ser Arg Leu Thr Val Gln Met
      50                  55                  60                
 Glu Asn Thr Tyr Gln Leu Gly Pro Pro Lys His Phe Pro Val Val Thr
  65                  70                  75                  80
 Val Asn His Ile Leu Lys Asp Val Val Thr Ser Tyr Leu Gln Val Glu
                  85                  90                  95    
 Glu Tyr Glu Pro Glu Leu Cys Arg Gln Met Thr Lys Thr Ile Ser Glu
             100                 105                 110        
 Val Ile Lys Ala Gln Val Lys Asp Leu Met Ile Pro Arg Tyr Lys Leu
         115                 120                 125            
 Ile Val Ile Val His Ile Gly Gln Leu Asn Arg Gln Ser Ile Leu Ile
     130                 135                 140                
 Gly Ser Arg Cys Leu Trp Asp Pro Lys Ser Asp Thr Phe Ser Ser Tyr
 145                 150                 155                 160
 Val Phe Arg Asn Ser Ser Leu Phe Ala Leu Ala Asn Val Tyr Ala Val
                 165                 170                 175    
 Tyr Leu Glu Val Ile Glu Asn Lys Lys Ser Ser Ser Tyr Phe
             180                 185                 190



      <210> 345
      <211> 870
      <212> PRT
      <213> Homo sapiens


      <400> 345
 Met Asn His Leu Asn Val Leu Ala Lys Ala Leu Tyr Asp Asn Val Ala
   1               5                  10                  15    
 Glu Ser Pro Asp Glu Leu Ser Phe Arg Lys Gly Asp Ile Met Thr Val
              20                  25                  30        
 Leu Glu Gln Asp Thr Gln Gly Leu Asp Gly Trp Trp Leu Cys Ser Leu
          35                  40                  45            
 His Gly Arg Gln Gly Ile Val Pro Gly Asn Arg Leu Lys Ile Leu Val
      50                  55                  60                
 Gly Met Tyr Asp Lys Lys Pro Ala Gly Pro Gly Ser Gly Pro Pro Ala
  65                  70                  75                  80
 Thr Pro Ala Gln Pro Gln Pro Gly Leu His Ala Pro Ala Pro Pro Ala
                  85                  90                  95    
 Ser Gln Tyr Thr Pro Met Leu Pro Asn Thr Tyr Gln Pro Gln Pro Asp
             100                 105                 110        
 Ser Val Tyr Leu Val Pro Thr Pro Ser Lys Ala Gln Gln Gly Leu Tyr
         115                 120                 125            
 Gln Val Pro Gly Pro Ser Pro Gln Phe Gln Ser Pro Pro Ala Lys Gln
     130                 135                 140                
 Thr Ser Thr Phe Ser Lys Gln Thr Pro His His Pro Phe Pro Ser Pro
 145                 150                 155                 160
 Ala Thr Asp Leu Tyr Gln Val Pro Pro Gly Pro Gly Gly Pro Ala Gln
                 165                 170                 175    
 Asp Ile Tyr Gln Val Pro Pro Ser Ala Gly Met Gly His Asp Ile Tyr
             180                 185                 190        
 Gln Val Pro Pro Ser Met Asp Thr Arg Ser Trp Glu Gly Thr Lys Pro
         195                 200                 205            
 Pro Ala Lys Val Val Val Pro Thr Arg Val Gly Gln Gly Tyr Val Tyr
     210                 215                 220                
 Glu Ala Ala Gln Pro Glu Gln Asp Glu Tyr Asp Thr Pro Arg His Leu
 225                 230                 235                 240
 Leu Ala Pro Gly Pro Gln Asp Ile Tyr Asp Val Pro Pro Val Arg Gly
                 245                 250                 255    
 Leu Leu Pro Ser Gln Tyr Gly Gln Glu Val Tyr Asp Thr Pro Pro Met
             260                 265                 270        
 Ala Val Lys Gly Pro Asn Gly Arg Asp Pro Leu Leu Glu Val Tyr Asp
         275                 280                 285            
 Val Pro Pro Ser Val Glu Lys Gly Leu Pro Pro Ser Asn His His Ala
     290                 295                 300                
 Val Tyr Asp Val Pro Pro Ser Val Ser Lys Asp Val Pro Asp Gly Pro
 305                 310                 315                 320
 Leu Leu Arg Glu Glu Thr Tyr Asp Val Pro Pro Ala Phe Ala Lys Ala
                 325                 330                 335    
 Lys Pro Phe Asp Pro Ala Arg Thr Pro Leu Val Leu Gly Ala Pro Pro
             340                 345                 350        
 Pro Asp Ser Pro Pro Ala Glu Asp Val Tyr Tyr Val Pro Pro Pro Ala
         355                 360                 365            
 Pro Asp Leu Tyr Asp Val Pro Pro Gly Leu Arg Arg Pro Gly Pro Gly
     370                 375                 380                
 Thr Leu Tyr Asp Val Pro Arg Glu Arg Val Leu Pro Pro Glu Val Ala
 385                 390                 395                 400
 Asp Gly Gly Val Val Asp Ser Gly Val Tyr Ala Val Pro Pro Pro Ala
                 405                 410                 415    
 Glu Arg Glu Ala Pro Ala Glu Gly Lys Arg Leu Ser Ala Ser Ser Thr
             420                 425                 430        
 Gly Ser Thr Arg Ser Ser Gln Ser Ala Ser Ser Leu Glu Val Ala Gly
         435                 440                 445            
 Pro Gly Arg Glu Pro Leu Glu Leu Glu Val Ala Val Glu Ala Leu Ala
     450                 455                 460                
 Arg Leu Gln Gln Gly Val Ser Ala Thr Val Ala His Leu Leu Asp Leu
 465                 470                 475                 480
 Ala Gly Ser Ala Gly Ala Thr Gly Ser Trp Arg Ser Pro Ser Glu Pro
                 485                 490                 495    
 Gln Glu Pro Leu Val Gln Asp Leu Gln Ala Ala Val Ala Ala Val Gln
             500                 505                 510        
 Ser Ala Val His Glu Leu Leu Glu Phe Ala Arg Ser Ala Val Gly Asn
         515                 520                 525            
 Ala Ala His Thr Ser Asp Arg Ala Leu His Ala Lys Leu Ser Arg Gln
     530                 535                 540                
 Leu Gln Lys Met Glu Asp Val His Gln Thr Leu Val Ala His Gly Gln
 545                 550                 555                 560
 Ala Leu Asp Ala Gly Arg Gly Gly Ser Gly Ala Thr Leu Glu Asp Leu
                 565                 570                 575    
 Asp Arg Leu Val Ala Cys Ser Arg Ala Val Pro Glu Asp Ala Lys Gln
             580                 585                 590        
 Leu Ala Ser Phe Leu His Gly Asn Ala Ser Leu Leu Phe Arg Arg Thr
         595                 600                 605            
 Lys Ala Thr Ala Pro Gly Pro Glu Gly Gly Gly Thr Leu His Pro Asn
     610                 615                 620                
 Pro Thr Asp Lys Thr Ser Ser Ile Gln Ser Arg Pro Leu Pro Ser Pro
 625                 630                 635                 640
 Pro Lys Phe Thr Ser Gln Asp Ser Pro Asp Gly Gln Tyr Glu Asn Ser
                 645                 650                 655    
 Glu Gly Gly Trp Met Glu Asp Tyr Asp Tyr Val His Leu Gln Gly Lys
             660                 665                 670        
 Glu Glu Phe Glu Lys Thr Gln Lys Glu Leu Leu Glu Lys Gly Ser Ile
         675                 680                 685            
 Thr Arg Gln Gly Lys Ser Gln Leu Glu Leu Gln Gln Leu Lys Gln Phe
     690                 695                 700                
 Glu Arg Leu Glu Gln Glu Val Ser Arg Pro Ile Asp His Asp Leu Ala
 705                 710                 715                 720
 Asn Trp Thr Pro Ala Gln Pro Leu Ala Pro Gly Arg Thr Gly Gly Leu
                 725                 730                 735    
 Gly Pro Ser Asp Arg Gln Leu Leu Leu Phe Tyr Leu Glu Gln Cys Glu
             740                 745                 750        
 Ala Asn Leu Thr Thr Leu Thr Asn Ala Val Asp Ala Phe Phe Thr Ala
         755                 760                 765            
 Val Ala Thr Asn Gln Pro Pro Lys Ile Phe Val Ala His Ser Lys Phe
     770                 775                 780                
 Val Ile Leu Ser Ala His Lys Leu Val Phe Ile Gly Asp Thr Leu Ser
 785                 790                 795                 800
 Arg Gln Ala Lys Ala Ala Asp Val Arg Thr Gln Val Thr His Tyr Ser
                 805                 810                 815    
 Asn Leu Leu Cys Asp Leu Leu Arg Gly Ile Val Ala Thr Thr Lys Ala
             820                 825                 830        
 Ala Ala Leu Gln Tyr Pro Ser Pro Ser Ala Ala Gln Asp Met Val Glu
         835                 840                 845            
 Arg Val Lys Glu Leu Gly His Ser Thr Gln Gln Phe Arg Arg Val Leu
     850                 855                 860                
 Gly Gln Leu Ala Ala Ala
 865                 870



      <210> 346
      <211> 391
      <212> PRT
      <213> Homo sapiens


      <400> 346
 Met Asp Arg Arg Lys Lys Pro Leu Asp Val Thr Ala Ser Ser Leu Val
   1               5                  10                  15    
 Asp Leu Lys Ala Glu Leu Phe Arg Lys Gln Glu Glu Phe Lys Gln Glu
              20                  25                  30        
 Lys Leu Leu Lys Asp Ser Gly Val Phe Gly Lys Pro Lys Thr Thr Asn
          35                  40                  45            
 Lys Lys Pro Ser Ile Trp Ser Lys Gln Asn Val Gly Val Ser Asn Arg
      50                  55                  60                
 Ala Glu Lys Asp Ala Glu Gln Lys Ile Glu Glu Gln Lys Thr Leu Asp
  65                  70                  75                  80
 Lys Ala Arg Glu Lys Leu Glu Glu Lys Ala Lys Leu Tyr Glu Lys Met
                  85                  90                  95    
 Thr Lys Gly Asp Phe Ile Asp Glu Glu Val Glu Asp Met Tyr Leu Val
             100                 105                 110        
 Asp Phe Thr Gln Lys Ile Ile Asp Lys Arg Lys Glu Met Glu Ala Ser
         115                 120                 125            
 Gly Ala His Arg Asp Ser Gln Lys Ala Gly Glu Arg Asp Asp Asp Glu
     130                 135                 140                
 Glu Asn Leu Pro Glu Gly Glu Ile Pro Pro Pro Gln Asp Pro Ser Glu
 145                 150                 155                 160
 Glu Trp Val Asp Tyr Val Asp Ser Leu Gly Arg Ser Arg Arg Cys Met
                 165                 170                 175    
 Arg Lys Asp Leu Pro Asp Leu Leu Glu Met Asp Lys Asn Leu Gln Gly
             180                 185                 190        
 Arg Leu Phe Ile Ser Pro Ala Asn Glu Lys Thr Leu Leu Ser Glu Asp
         195                 200                 205            
 Met Arg Lys Glu Leu Gln Arg Gln Gln Trp Glu Glu Glu Glu Arg Glu
     210                 215                 220                
 Ala Leu Lys Arg Pro Met Gly Pro Val His Tyr Glu Asp Ile Arg Glu
 225                 230                 235                 240
 Asn Asp Gly Asp Val Ile Gly Pro Leu Pro Pro Glu Pro Glu Ala Val
                 245                 250                 255    
 Pro Thr Pro Arg Pro Ala Ala Gln Ser Ser Lys Val Glu Val Ile Val
             260                 265                 270        
 Gln Glu Arg Lys Asp Thr Lys Pro Gly Val Pro His Ile Arg Glu Trp
         275                 280                 285            
 Asp Arg Gly Lys Glu Phe Ser Phe Gly Tyr Trp Ser Lys Arg Gln Ser
     290                 295                 300                
 Asp Leu Arg Ala Glu Arg Asp Pro Glu Phe Ala Pro Pro Ser Asp Tyr
 305                 310                 315                 320
 Phe Val Gly Gln Lys Arg Thr Gly Phe Ser Ser Ser Gln Ala Trp Ser
                 325                 330                 335    
 Arg Pro Gly Pro Ala Gln Ser Asp Pro Gly Gln Cys Pro Asp Gln Ser
             340                 345                 350        
 His Gly Pro Ser Pro Glu His Thr Ser Pro Thr Pro Ala Pro Asp Asn
         355                 360                 365            
 Pro Pro Gln Ala Pro Thr Val Thr Phe Lys Thr Leu Asp Asp Met Ile
     370                 375                 380                
 Ser Tyr Tyr Lys Gln Val Thr
 385                 390    



      <210> 347
      <211> 467
      <212> PRT
      <213> Homo sapiens


      <400> 347
 Met Asp Arg Arg Lys Lys Pro Leu Asp Val Thr Ala Ser Ser Leu Val
   1               5                  10                  15    
 Asp Leu Lys Ala Glu Leu Phe Arg Lys Gln Glu Glu Phe Lys Gln Glu
              20                  25                  30        
 Lys Leu Leu Lys Asp Ser Gly Val Phe Gly Lys Pro Lys Thr Thr Asn
          35                  40                  45            
 Lys Lys Pro Ser Ile Trp Ser Lys Gln Asn Val Gly Val Ser Asn Arg
      50                  55                  60                
 Ala Glu Lys Asp Ala Glu Gln Lys Ile Glu Glu Gln Lys Thr Leu Asp
  65                  70                  75                  80
 Lys Ala Arg Glu Lys Leu Glu Glu Lys Ala Lys Leu Tyr Glu Lys Met
                  85                  90                  95    
 Thr Lys Gly Asp Phe Ile Asp Glu Glu Val Glu Asp Met Tyr Leu Val
             100                 105                 110        
 Asp Phe Thr Gln Lys Ile Ile Asp Lys Arg Lys Glu Met Glu Ala Ser
         115                 120                 125            
 Gly Ala His Arg Asp Ser Gln Lys Ala Gly Glu Arg Asp Asp Asp Glu
     130                 135                 140                
 Glu Asn Leu Pro Glu Gly Glu Ile Pro Pro Pro Gln Asp Pro Ser Glu
 145                 150                 155                 160
 Glu Trp Val Asp Tyr Val Asp Ser Leu Gly Arg Ser Arg Arg Cys Met
                 165                 170                 175    
 Arg Lys Asp Leu Pro Asp Leu Leu Glu Met Asp Lys Asn Leu Gln Gly
             180                 185                 190        
 Arg Leu Phe Ile Ser Pro Ala Asn Glu Lys Thr Leu Leu Ser Glu Asp
         195                 200                 205            
 Met Arg Lys Glu Leu Gln Arg Gln Gln Trp Glu Glu Glu Glu Arg Glu
     210                 215                 220                
 Ala Leu Lys Arg Pro Met Gly Pro Val His Tyr Glu Asp Ile Arg Glu
 225                 230                 235                 240
 Asn Glu Ala Arg Gln Leu Gly Val Gly Tyr Phe Ala Phe Ala Arg Asp
                 245                 250                 255    
 Lys Glu Leu Arg Asn Lys Gln Met Lys Thr Leu Glu Met Leu Arg Glu
             260                 265                 270        
 Gln Thr Thr Asp Gln Arg Thr Lys Arg Glu Asn Ile Lys Glu Lys Arg
         275                 280                 285            
 Lys Ala Ile Leu Glu Ala Arg Leu Ala Lys Leu Arg Gln Lys Arg Met
     290                 295                 300                
 Lys Lys Ser Lys Glu Gly Gly Thr Glu Glu Glu Asn Arg Asp Gly Asp
 305                 310                 315                 320
 Val Ile Gly Pro Leu Pro Pro Glu Pro Glu Ala Val Pro Thr Pro Arg
                 325                 330                 335    
 Pro Ala Ala Gln Ser Ser Lys Val Glu Val Ile Val Gln Glu Arg Lys
             340                 345                 350        
 Asp Thr Lys Pro Gly Val Pro His Ile Arg Glu Trp Asp Arg Gly Lys
         355                 360                 365            
 Glu Phe Ser Phe Gly Tyr Trp Ser Lys Arg Gln Ser Asp Leu Arg Ala
     370                 375                 380                
 Glu Arg Asp Pro Glu Phe Ala Pro Pro Ser Asp Tyr Phe Val Gly Gln
 385                 390                 395                 400
 Lys Arg Thr Gly Phe Ser Ser Ser Gln Ala Trp Ser Arg Pro Gly Pro
                 405                 410                 415    
 Ala Gln Ser Asp Pro Gly Gln Cys Pro Asp Gln Ser His Gly Pro Ser
             420                 425                 430        
 Pro Glu His Thr Ser Pro Thr Pro Ala Pro Asp Asn Pro Pro Gln Ala
         435                 440                 445            
 Pro Thr Val Thr Phe Lys Thr Leu Asp Asp Met Ile Ser Tyr Tyr Lys
     450                 455                 460                
 Gln Val Thr
 465        



      <210> 348
      <211> 80
      <212> PRT
      <213> Homo sapiens


      <400> 348
 Met Phe Pro Leu Val Lys Ser Ala Leu Asn Arg Leu Gln Val Arg Ser
   1               5                  10                  15    
 Ile Gln Gln Thr Met Ala Arg Gln Ser His Gln Lys Arg Thr Pro Asp
              20                  25                  30        
 Phe His Asp Lys Tyr Gly Asn Ala Val Leu Ala Ser Gly Ala Thr Phe
          35                  40                  45            
 Cys Ile Val Thr Trp Thr Tyr Val Ala Thr Gln Val Gly Ile Glu Trp
      50                  55                  60                
 Asn Leu Ser Pro Val Gly Arg Val Thr Pro Lys Glu Trp Arg Asn Gln
  65                  70                  75                  80





      <210> 349
      <211> 122
      <212> PRT
      <213> Homo sapiens


      <400> 349
 Met Leu Ile Tyr Pro Met Gly Leu Leu Lys Gly Thr Met Ser Gly Arg
   1               5                  10                  15    
 Leu Trp Ser Lys Ala Ile Phe Ala Gly Tyr Lys Arg Gly Leu Arg Asn
              20                  25                  30        
 Gln Arg Glu His Thr Ala Leu Leu Lys Ile Glu Gly Val Tyr Ala Arg
          35                  40                  45            
 Asp Glu Thr Glu Phe Tyr Leu Gly Lys Arg Cys Ala Tyr Val Tyr Lys
      50                  55                  60                
 Ala Lys Asn Asn Thr Val Thr Pro Gly Gly Lys Pro Asn Lys Thr Arg
  65                  70                  75                  80
 Val Ile Trp Gly Lys Val Thr Arg Ala His Gly Asn Ser Gly Met Val
                  85                  90                  95    
 Arg Ala Lys Phe Arg Ser Asn Leu Pro Ala Lys Ala Ile Gly His Arg
             100                 105                 110        
 Ile Arg Val Met Leu Tyr Pro Ser Arg Ile
         115                 120        



      <210> 350
      <211> 2969
      <212> PRT
      <213> Homo sapiens


      <400> 350
 Met Asp Pro Arg Asn Thr Ala Met Leu Gly Leu Gly Ser Asp Ser Glu
   1               5                  10                  15    
 Gly Phe Ser Arg Lys Ser Pro Ser Ala Ile Ser Thr Gly Thr Leu Val
              20                  25                  30        
 Ser Lys Arg Glu Val Glu Leu Glu Lys Asn Thr Lys Glu Glu Glu Asp
          35                  40                  45            
 Leu Arg Lys Arg Asn Arg Glu Arg Asn Ile Glu Thr Gly Lys Asp Asp
      50                  55                  60                
 Gly Leu Thr Asp Ala Gln Gln Gln Phe Ser Val Lys Glu Thr Asn Phe
  65                  70                  75                  80
 Ser Glu Gly Ile Leu Lys Leu Lys Ile Gly Leu Gln Ala Lys Arg Thr
                  85                  90                  95    
 Lys Lys Pro Pro Lys Asn Leu Glu Asn Tyr Val Cys Arg Pro Ala Ile
             100                 105                 110        
 Lys Thr Thr Ile Lys His Pro Arg Lys Ala Leu Lys Ser Gly Lys Met
         115                 120                 125            
 Thr Asp Glu Lys Asn Glu His Cys Pro Ser Lys Arg Asp Pro Ser Lys
     130                 135                 140                
 Leu Tyr Lys Lys Ala Asp Asp Val Ala Ala Ile Glu Cys Gln Ser Glu
 145                 150                 155                 160
 Glu Val Ile Arg Leu His Ser Gln Gly Glu Asn Asn Pro Leu Ser Lys
                 165                 170                 175    
 Lys Leu Ser Pro Val His Ser Glu Met Ala Asp Tyr Ile Asn Ala Thr
             180                 185                 190        
 Pro Ser Thr Leu Leu Gly Ser Arg Asp Pro Asp Leu Lys Asp Arg Ala
         195                 200                 205            
 Leu Leu Asn Gly Gly Thr Ser Val Thr Glu Lys Leu Ala Gln Leu Ile
     210                 215                 220                
 Ala Thr Cys Pro Pro Ser Lys Ser Ser Lys Thr Lys Pro Lys Lys Leu
 225                 230                 235                 240
 Gly Thr Gly Thr Thr Ala Gly Leu Val Ser Lys Asp Leu Ile Arg Lys
                 245                 250                 255    
 Ala Gly Val Gly Ser Val Ala Gly Ile Ile His Lys Asp Leu Ile Lys
             260                 265                 270        
 Lys Pro Thr Ile Ser Thr Ala Val Gly Leu Val Thr Lys Asp Pro Gly
         275                 280                 285            
 Lys Lys Pro Val Phe Asn Ala Ala Val Gly Leu Val Asn Lys Asp Ser
     290                 295                 300                
 Val Lys Lys Leu Gly Thr Gly Thr Thr Ala Val Phe Ile Asn Lys Asn
 305                 310                 315                 320
 Leu Gly Lys Lys Pro Gly Thr Ile Thr Thr Val Gly Leu Leu Ser Lys
                 325                 330                 335    
 Asp Ser Gly Lys Lys Leu Gly Ile Gly Ile Val Pro Gly Leu Val His
             340                 345                 350        
 Lys Glu Ser Gly Lys Lys Leu Gly Leu Gly Thr Val Val Gly Leu Val
         355                 360                 365            
 Asn Lys Asp Leu Gly Lys Lys Leu Gly Ser Thr Val Gly Leu Val Ala
     370                 375                 380                
 Lys Asp Cys Ala Lys Lys Ile Val Ala Ser Ser Ala Met Gly Leu Val
 385                 390                 395                 400
 Asn Lys Asp Ile Gly Lys Lys Leu Met Ser Cys Pro Leu Ala Gly Leu
                 405                 410                 415    
 Ile Ser Lys Asp Ala Ile Asn Leu Lys Ala Glu Ala Leu Leu Pro Thr
             420                 425                 430        
 Gln Glu Pro Leu Lys Ala Ser Cys Ser Thr Asn Ile Asn Asn Gln Glu
         435                 440                 445            
 Ser Gln Glu Leu Ser Glu Ser Leu Lys Asp Ser Ala Thr Ser Lys Thr
     450                 455                 460                
 Phe Glu Lys Asn Val Val Arg Gln Asn Lys Glu Ser Ile Leu Glu Lys
 465                 470                 475                 480
 Phe Ser Val Arg Lys Glu Ile Ile Asn Leu Glu Lys Glu Met Phe Asn
                 485                 490                 495    
 Glu Gly Thr Cys Ile Gln Gln Asp Ser Phe Ser Ser Ser Glu Lys Gly
             500                 505                 510        
 Ser Tyr Glu Thr Ser Lys His Glu Lys Gln Pro Pro Val Tyr Cys Thr
         515                 520                 525            
 Ser Pro Asp Phe Lys Met Gly Gly Ala Ser Asp Val Ser Thr Ala Lys
     530                 535                 540                
 Ser Pro Phe Ser Ala Val Gly Glu Ser Asn Leu Pro Ser Pro Ser Pro
 545                 550                 555                 560
 Thr Val Ser Val Asn Pro Leu Thr Arg Ser Pro Pro Glu Ile Ser Ser
                 565                 570                 575    
 Gln Leu Ala Pro Asn Pro Leu Leu Leu Ser Ser Thr Thr Glu Leu Ile
             580                 585                 590        
 Glu Glu Val Ser Glu Ser Val Gly Lys Asn Gln Phe Thr Ser Glu Ser
         595                 600                 605            
 Thr His Leu Asn Val Gly His Arg Ser Val Gly His Ser Ile Ser Ile
     610                 615                 620                
 Glu Cys Lys Gly Ile Asp Lys Glu Val Asn Asp Ser Lys Thr Thr His
 625                 630                 635                 640
 Ile Asp Ile Pro Arg Ile Ser Ser Ser Leu Gly Lys Lys Pro Ser Leu
                 645                 650                 655    
 Thr Ser Glu Ser Ser Ile His Thr Ile Thr Pro Ser Val Val Asn Phe
             660                 665                 670        
 Thr Ser Leu Phe Ser Asn Lys Pro Phe Leu Lys Leu Gly Ala Val Ser
         675                 680                 685            
 Ala Ser Asp Lys His Cys Gln Val Ala Glu Ser Leu Ser Thr Ser Leu
     690                 695                 700                
 Gln Ser Lys Pro Leu Lys Lys Arg Lys Gly Arg Lys Pro Arg Trp Thr
 705                 710                 715                 720
 Lys Val Val Ala Arg Ser Thr Cys Arg Ser Pro Lys Gly Leu Glu Leu
                 725                 730                 735    
 Glu Arg Ser Glu Leu Phe Lys Asn Val Ser Cys Ser Ser Leu Ser Asn
             740                 745                 750        
 Ser Asn Ser Glu Pro Ala Lys Phe Met Lys Asn Ile Gly Pro Pro Ser
         755                 760                 765            
 Phe Val Asp His Asp Phe Leu Lys Arg Arg Leu Pro Lys Leu Ser Lys
     770                 775                 780                
 Ser Thr Ala Pro Ser Leu Ala Leu Leu Ala Asp Ser Glu Lys Pro Ser
 785                 790                 795                 800
 His Lys Ser Phe Ala Thr His Lys Leu Ser Ser Ser Met Cys Val Ser
                 805                 810                 815    
 Ser Asp Leu Leu Ser Asp Ile Tyr Lys Pro Lys Arg Gly Arg Pro Lys
             820                 825                 830        
 Ser Lys Glu Met Pro Gln Leu Glu Gly Pro Pro Lys Arg Thr Leu Lys
         835                 840                 845            
 Ile Pro Ala Ser Lys Val Phe Ser Leu Gln Ser Lys Glu Glu Gln Glu
     850                 855                 860                
 Pro Pro Ile Leu Gln Pro Glu Ile Glu Ile Pro Ser Phe Lys Gln Gly
 865                 870                 875                 880
 Leu Ser Val Ser Pro Phe Pro Lys Lys Arg Gly Arg Pro Lys Arg Gln
                 885                 890                 895    
 Met Arg Ser Pro Val Lys Met Lys Pro Pro Val Leu Ser Val Ala Pro
             900                 905                 910        
 Phe Val Ala Thr Glu Ser Pro Ser Lys Leu Glu Ser Glu Ser Asp Asn
         915                 920                 925            
 His Arg Ser Ser Ser Asp Phe Phe Glu Ser Glu Asp Gln Leu Gln Asp
     930                 935                 940                
 Pro Asp Asp Leu Asp Asp Ser His Arg Pro Ser Val Cys Ser Met Ser
 945                 950                 955                 960
 Asp Leu Glu Met Glu Pro Asp Lys Lys Ile Thr Lys Arg Asn Asn Gly
                 965                 970                 975    
 Gln Leu Met Lys Thr Ile Ile Arg Lys Ile Asn Lys Met Lys Thr Leu
             980                 985                 990        
 Lys Arg Lys Lys Leu Leu Asn Gln Ile Leu Ser Ser Ser Val Glu Ser
         995                1000                1005            
 Ser Asn Lys Gly Lys Val Gln Ser Lys Leu His Asn Thr Val Ser Ser
    1010                1015                1020                
 Leu Ala Ala Thr Phe Gly Ser Lys Leu Gly Gln Gln Ile Asn Val Ser
1025                1030                1035                1040
 Lys Lys Gly Thr Ile Tyr Ile Gly Lys Arg Arg Gly Arg Lys Pro Lys
                1045                1050                1055    
 Thr Val Leu Asn Gly Ile Leu Ser Gly Ser Pro Thr Ser Leu Ala Val
            1060                1065                1070        
 Leu Glu Gln Thr Ala Gln Gln Ala Ala Gly Ser Ala Leu Gly Gln Ile
        1075                1080                1085            
 Leu Pro Pro Leu Leu Pro Ser Ser Ala Ser Ser Ser Glu Ile Leu Pro
    1090                1095                1100                
 Ser Pro Ile Cys Ser Gln Ser Ser Gly Thr Ser Gly Gly Gln Ser Pro
1105                1110                1115                1120
 Val Ser Ser Asp Ala Gly Phe Val Glu Pro Ser Ser Val Pro Tyr Leu
                1125                1130                1135    
 His Leu His Ser Arg Gln Gly Ser Met Ile Gln Thr Leu Ala Met Lys
            1140                1145                1150        
 Lys Ala Ser Lys Gly Arg Arg Arg Leu Ser Pro Pro Thr Leu Leu Pro
        1155                1160                1165            
 Asn Ser Pro Ser His Leu Ser Glu Leu Thr Ser Leu Lys Glu Ala Thr
    1170                1175                1180                
 Pro Ser Pro Ile Ser Glu Ser His Ser Asp Glu Thr Ile Pro Ser Asp
1185                1190                1195                1200
 Ser Gly Ile Gly Thr Asp Asn Asn Ser Thr Ser Asp Arg Ala Glu Lys
                1205                1210                1215    
 Phe Cys Gly Gln Lys Lys Arg Arg His Ser Phe Glu His Val Ser Leu
            1220                1225                1230        
 Ile Pro Pro Glu Thr Ser Thr Val Leu Ser Ser Leu Lys Glu Lys His
        1235                1240                1245            
 Lys His Lys Cys Lys Arg Arg Asn His Asp Tyr Leu Ser Tyr Asp Lys
    1250                1255                1260                
 Met Lys Arg Gln Lys Arg Lys Arg Lys Lys Lys Tyr Pro Gln Leu Arg
1265                1270                1275                1280
 Asn Arg Gln Asp Pro Asp Phe Ile Ala Glu Leu Glu Glu Leu Ile Ser
                1285                1290                1295    
 Arg Leu Ser Glu Ile Arg Ile Thr His Arg Ser His His Phe Ile Pro
            1300                1305                1310        
 Arg Asp Leu Leu Pro Thr Ile Phe Arg Ile Asn Phe Asn Ser Phe Tyr
        1315                1320                1325            
 Thr His Pro Ser Phe Pro Leu Asp Pro Leu His Tyr Ile Arg Lys Pro
    1330                1335                1340                
 Asp Leu Lys Lys Lys Arg Gly Arg Pro Pro Lys Met Arg Glu Ala Met
1345                1350                1355                1360
 Ala Glu Met Pro Phe Met His Ser Leu Ser Phe Pro Leu Ser Ser Thr
                1365                1370                1375    
 Gly Phe Tyr Pro Ser Tyr Gly Met Pro Tyr Ser Pro Ser Pro Leu Thr
            1380                1385                1390        
 Ala Ala Pro Ile Gly Leu Gly Tyr Tyr Gly Arg Tyr Pro Pro Thr Leu
        1395                1400                1405            
 Tyr Pro Pro Pro Pro Ser Pro Ser Phe Thr Thr Pro Leu Pro Pro Pro
    1410                1415                1420                
 Ser Tyr Met His Ala Gly His Leu Leu Leu Asn Pro Ala Lys Tyr His
1425                1430                1435                1440
 Lys Lys Lys His Lys Leu Leu Arg Gln Glu Ala Phe Leu Thr Thr Ser
                1445                1450                1455    
 Arg Thr Pro Leu Leu Ser Met Ser Thr Tyr Pro Ser Val Pro Pro Glu
            1460                1465                1470        
 Met Ala Tyr Gly Trp Met Val Glu His Lys His Arg His Arg His Lys
        1475                1480                1485            
 His Arg Glu His Arg Ser Ser Glu Gln Pro Gln Val Ser Met Asp Thr
    1490                1495                1500                
 Gly Ser Ser Arg Ser Val Leu Glu Ser Leu Lys Arg Tyr Arg Phe Gly
1505                1510                1515                1520
 Lys Asp Ala Val Gly Glu Arg Tyr Lys His Lys Glu Lys His Arg Cys
                1525                1530                1535    
 His Met Ser Cys Pro His Leu Ser Pro Ser Lys Ser Leu Ile Asn Arg
            1540                1545                1550        
 Glu Glu Gln Trp Val His Arg Glu Pro Ser Glu Ser Ser Pro Leu Ala
        1555                1560                1565            
 Leu Gly Leu Gln Thr Pro Leu Gln Ile Asp Cys Ser Glu Ser Ser Pro
    1570                1575                1580                
 Ser Leu Ser Leu Gly Gly Phe Thr Pro Asn Ser Glu Pro Ala Ser Ser
1585                1590                1595                1600
 Asp Glu His Thr Asn Leu Phe Thr Ser Ala Ile Gly Ser Cys Arg Val
                1605                1610                1615    
 Ser Asn Pro Asn Ser Ser Gly Arg Lys Lys Leu Thr Asp Ser Pro Gly
            1620                1625                1630        
 Leu Phe Ser Ala Gln Asp Thr Ser Leu Asn Arg Leu His Arg Lys Glu
        1635                1640                1645            
 Ser Leu Pro Ser Asn Glu Arg Ala Val Gln Thr Leu Ala Gly Ser Gln
    1650                1655                1660                
 Pro Thr Ser Asp Lys Pro Ser Gln Arg Pro Ser Glu Ser Thr Asn Cys
1665                1670                1675                1680
 Ser Pro Thr Arg Lys Arg Ser Ser Ser Glu Ser Thr Ser Ser Thr Val
                1685                1690                1695    
 Asn Gly Val Pro Ser Arg Ser Pro Arg Leu Val Ala Ser Gly Asp Asp
            1700                1705                1710        
 Ser Val Asp Ser Leu Leu Gln Arg Met Val Gln Asn Glu Asp Gln Glu
        1715                1720                1725            
 Pro Met Glu Lys Ser Ile Asp Ala Val Ile Ala Thr Ala Ser Ala Pro
    1730                1735                1740                
 Pro Ser Ser Ser Pro Gly Arg Ser His Ser Lys Asp Arg Thr Leu Gly
1745                1750                1755                1760
 Lys Pro Asp Ser Leu Leu Val Pro Ala Val Ala Ser Asp Ser Cys Asn
                1765                1770                1775    
 Asn Ser Ile Ser Leu Leu Ser Glu Lys Leu Thr Ser Ser Cys Ser Pro
            1780                1785                1790        
 His His Ile Lys Arg Ser Val Val Glu Ala Met Gln Arg Gln Ala Arg
        1795                1800                1805            
 Lys Met Cys Asn Tyr Asp Lys Ile Leu Ala Thr Lys Lys Asn Leu Asp
    1810                1815                1820                
 His Val Asn Lys Ile Leu Lys Ala Lys Lys Leu Gln Arg Gln Ala Arg
1825                1830                1835                1840
 Thr Gly Asn Asn Phe Val Lys Arg Arg Pro Gly Arg Pro Arg Lys Cys
                1845                1850                1855    
 Pro Leu Gln Ala Val Val Ser Met Gln Ala Phe Gln Ala Ala Gln Phe
            1860                1865                1870        
 Val Asn Pro Glu Leu Asn Arg Asp Glu Glu Gly Ala Ala Leu His Leu
        1875                1880                1885            
 Ser Pro Asp Thr Val Thr Asp Val Ile Glu Ala Val Val Gln Ser Val
    1890                1895                1900                
 Asn Leu Asn Pro Glu His Lys Lys Gly Leu Lys Arg Lys Gly Trp Leu
1905                1910                1915                1920
 Leu Glu Glu Gln Thr Arg Lys Lys Gln Lys Pro Leu Pro Glu Glu Glu
                1925                1930                1935    
 Glu Gln Glu Asn Asn Lys Ser Phe Asn Glu Ala Pro Val Glu Ile Pro
            1940                1945                1950        
 Ser Pro Ser Glu Thr Pro Ala Lys Pro Ser Glu Pro Glu Ser Thr Leu
        1955                1960                1965            
 Gln Pro Val Leu Ser Leu Ile Pro Arg Glu Lys Lys Pro Pro Arg Pro
    1970                1975                1980                
 Pro Lys Lys Lys Tyr Gln Lys Ala Gly Leu Tyr Ser Asp Val Tyr Lys
1985                1990                1995                2000
 Thr Thr Asp Pro Lys Ser Arg Leu Ile Gln Leu Lys Lys Glu Lys Leu
                2005                2010                2015    
 Glu Tyr Thr Pro Gly Glu His Glu Tyr Gly Leu Phe Pro Ala Pro Ile
            2020                2025                2030        
 His Val Val Phe Phe Val Ser Gly Lys Tyr Leu Arg Gln Lys Arg Ile
        2035                2040                2045            
 Asp Phe Gln Leu Pro Tyr Asp Ile Leu Trp Gln Trp Lys His Asn Gln
    2050                2055                2060                
 Leu Tyr Lys Lys Pro Asp Val Pro Leu Tyr Lys Lys Ile Arg Ser Asn
2065                2070                2075                2080
 Val Tyr Val Asp Val Lys Pro Leu Ser Gly Tyr Glu Ala Thr Thr Cys
                2085                2090                2095    
 Asn Cys Lys Lys Pro Asp Asp Asp Thr Arg Lys Gly Cys Val Asp Asp
            2100                2105                2110        
 Cys Leu Asn Arg Met Ile Phe Ala Glu Cys Ser Pro Asn Thr Cys Pro
        2115                2120                2125            
 Cys Gly Glu Gln Cys Cys Asn Gln Arg Ile Gln Arg His Glu Trp Val
    2130                2135                2140                
 Gln Cys Leu Glu Arg Phe Arg Ala Glu Glu Lys Gly Trp Gly Ile Arg
2145                2150                2155                2160
 Thr Lys Glu Pro Leu Lys Ala Gly Gln Phe Ile Ile Glu Tyr Leu Gly
                2165                2170                2175    
 Glu Val Val Ser Glu Gln Glu Phe Arg Asn Arg Met Ile Glu Gln Tyr
            2180                2185                2190        
 His Asn His Ser Asp His Tyr Cys Leu Asn Leu Asp Ser Gly Met Val
        2195                2200                2205            
 Ile Asp Ser Tyr Arg Met Gly Asn Glu Ala Arg Phe Ile Asn His Ser
    2210                2215                2220                
 Cys Asp Pro Asn Cys Glu Met Gln Lys Trp Ser Val Asn Gly Val Tyr
2225                2230                2235                2240
 Arg Ile Gly Leu Tyr Ala Leu Lys Asp Met Pro Ala Gly Thr Glu Leu
                2245                2250                2255    
 Thr Tyr Asp Tyr Asn Phe His Ser Phe Asn Val Glu Lys Gln Gln Leu
            2260                2265                2270        
 Cys Lys Cys Gly Phe Glu Lys Cys Arg Gly Ile Ile Gly Gly Lys Ser
        2275                2280                2285            
 Gln Arg Val Asn Gly Leu Thr Ser Ser Lys Asn Ser Gln Pro Met Ala
    2290                2295                2300                
 Thr His Lys Lys Ser Gly Arg Ser Lys Glu Lys Arg Lys Ser Lys His
2305                2310                2315                2320
 Lys Leu Lys Lys Arg Arg Gly His Leu Ser Glu Glu Pro Ser Glu Asn
                2325                2330                2335    
 Ile Asn Thr Pro Thr Arg Leu Thr Pro Gln Leu Gln Met Lys Pro Met
            2340                2345                2350        
 Ser Asn Arg Glu Arg Asn Phe Val Leu Lys His His Val Phe Leu Val
        2355                2360                2365            
 Arg Asn Trp Glu Lys Ile Arg Gln Lys Gln Glu Glu Val Lys His Thr
    2370                2375                2380                
 Ser Asp Asn Ile His Ser Ala Ser Leu Tyr Thr Arg Trp Asn Gly Ile
2385                2390                2395                2400
 Cys Arg Asp Asp Gly Asn Ile Lys Ser Asp Val Phe Met Thr Gln Phe
                2405                2410                2415    
 Ser Ala Leu Gln Thr Ala Arg Ser Val Arg Thr Arg Arg Leu Ala Ala
            2420                2425                2430        
 Ala Glu Glu Asn Ile Glu Val Ala Arg Ala Ala Arg Leu Ala Gln Ile
        2435                2440                2445            
 Phe Lys Glu Ile Cys Asp Gly Ile Ile Ser Tyr Lys Asp Ser Ser Arg
    2450                2455                2460                
 Gln Ala Leu Ala Ala Pro Leu Leu Asn Leu Pro Pro Lys Lys Lys Asn
2465                2470                2475                2480
 Ala Asp Tyr Tyr Glu Lys Ile Ser Asp Pro Leu Asp Leu Ile Thr Ile
                2485                2490                2495    
 Glu Lys Gln Ile Leu Thr Gly Tyr Tyr Lys Thr Val Glu Ala Phe Asp
            2500                2505                2510        
 Ala Asp Met Leu Lys Val Phe Arg Asn Ala Glu Lys Tyr Tyr Gly Arg
        2515                2520                2525            
 Lys Ser Pro Val Gly Arg Asp Val Cys Arg Leu Arg Lys Ala Tyr Tyr
    2530                2535                2540                
 Asn Ala Arg His Glu Ala Ser Ala Gln Ile Asp Glu Ile Val Gly Glu
2545                2550                2555                2560
 Thr Ala Ser Glu Ala Asp Ser Ser Glu Thr Ser Val Ser Glu Lys Glu
                2565                2570                2575    
 Asn Gly His Glu Lys Asp Asp Asp Val Ile Arg Cys Ile Cys Gly Leu
            2580                2585                2590        
 Tyr Asn Asp Glu Gly Leu Met Ile Gln Cys Asp Lys Cys Met Val Trp
        2595                2600                2605            
 Gln His Cys Asp Cys Met Gly Val Asn Ser Asp Val Glu His Tyr Leu
    2610                2615                2620                
 Cys Glu Gln Cys Asp Pro Arg Pro Val Asp Arg Glu Val Pro Met Ile
2625                2630                2635                2640
 Pro Arg Pro His Tyr Ala Gln Pro Gly Cys Val Tyr Phe Ile Cys Leu
                2645                2650                2655    
 Leu Arg Asp Asp Leu Leu Leu Arg Gln Gly Asp Cys Val Tyr Leu Met
            2660                2665                2670        
 Arg Asp Ser Arg Arg Thr Pro Asp Gly His Pro Val Arg Gln Ser Tyr
        2675                2680                2685            
 Arg Leu Leu Ser His Ile Asn Arg His Lys Leu Asp Ile Phe Arg Ile
    2690                2695                2700                
 Glu Lys Leu Trp Lys Asn Glu Lys Glu Glu Arg Phe Ala Phe Gly His
2705                2710                2715                2720
 His Tyr Phe Arg Pro His Glu Thr His His Ser Pro Ser Arg Arg Phe
                2725                2730                2735    
 Tyr His Asn Glu Leu Phe Arg Val Pro Leu Tyr Glu Ile Ile Pro Leu
            2740                2745                2750        
 Glu Ala Val Val Gly Thr Cys Cys Val Leu Asp Leu Tyr Thr Tyr Cys
        2755                2760                2765            
 Lys Gly Arg Pro Lys Gly Val Lys Glu Gln Asp Val Tyr Ile Cys Asp
    2770                2775                2780                
 Tyr Arg Leu Asp Lys Ser Ala His Leu Phe Tyr Lys Ile His Arg Asn
2785                2790                2795                2800
 Arg Tyr Pro Val Cys Thr Lys Pro Tyr Ala Phe Asp His Phe Pro Lys
                2805                2810                2815    
 Lys Leu Thr Pro Lys Lys Asp Phe Ser Pro His Tyr Val Pro Asp Asn
            2820                2825                2830        
 Tyr Lys Arg Asn Gly Gly Arg Ser Ser Trp Lys Ser Glu Arg Ser Lys
        2835                2840                2845            
 Pro Pro Leu Lys Asp Leu Gly Gln Glu Asp Asp Ala Leu Pro Leu Ile
    2850                2855                2860                
 Glu Glu Val Leu Ala Ser Gln Glu Gln Ala Ala Asn Glu Ile Pro Ser
2865                2870                2875                2880
 Leu Glu Glu Pro Glu Arg Glu Gly Ala Thr Ala Asn Val Ser Glu Gly
                2885                2890                2895    
 Glu Lys Lys Thr Glu Glu Ser Ser Gln Glu Pro Gln Ser Thr Cys Thr
            2900                2905                2910        
 Pro Glu Glu Arg Arg His Asn Gln Arg Glu Arg Leu Asn Gln Ile Leu
        2915                2920                2925            
 Leu Asn Leu Leu Glu Lys Ile Pro Gly Lys Asn Ala Ile Asp Val Thr
    2930                2935                2940                
 Tyr Leu Leu Glu Glu Gly Ser Gly Arg Lys Leu Arg Arg Arg Thr Leu
2945                2950                2955                2960
 Phe Ile Pro Glu Asn Ser Phe Arg Lys
                2965                



      <210> 351
      <211> 60
      <212> PRT
      <213> Homo sapiens


      <400> 351
 Met Gln Gln Thr Asn Ile Ala His Phe Lys Phe Lys Leu Pro Gly Ser
   1               5                  10                  15    
 Ser Asp Pro Pro Thr Ser Ala Ser Gln Val Ala Arg Thr Lys Ser Ala
              20                  25                  30        
 His His His Met Gln Leu Ile Phe Phe Val Glu Met Gly Phe Cys His
          35                  40                  45            
 Val Ala Gln Ala Gly Ser Arg Asn Pro Gly Leu Lys
      50                  55                  60



      <210> 352
      <211> 120
      <212> PRT
      <213> Homo sapiens


      <400> 352
 Met Val Leu Arg Val Arg Gly Asp Gly Ala Ser Glu Glu Met Glu Gln
   1               5                  10                  15    
 Lys Leu Val Glu Glu Ile Leu Gln Ala Ile Thr Met Ser Thr Asp Thr
              20                  25                  30        
 Gly Val Ser Leu Pro Ser Tyr Glu Glu Asp Gln Gly Ser Lys Leu Ile
          35                  40                  45            
 Arg Lys Ala Lys Glu Ala Pro Phe Val Pro Val Gly Ile Ala Gly Phe
      50                  55                  60                
 Ala Ala Ile Val Ala Tyr Gly Leu Tyr Lys Leu Lys Ser Arg Gly Asn
  65                  70                  75                  80
 Thr Lys Met Ser Ile His Leu Ile His Met Arg Val Ala Ala Gln Gly
                  85                  90                  95    
 Phe Val Val Gly Ala Met Thr Val Gly Met Gly Tyr Ser Met Tyr Arg
             100                 105                 110        
 Glu Phe Trp Ala Lys Pro Lys Pro
         115                 120



      <210> 353
      <211> 95
      <212> PRT
      <213> Homo sapiens


      <400> 353
 Met Met Met Thr Ala Thr Gln Arg Ala Arg His Pro Thr Gln Ala His
   1               5                  10                  15    
 Phe Lys Ile Leu Leu Ala Ser Ser Leu Leu Lys Phe Leu Tyr Pro Lys
              20                  25                  30        
 Gln Gly Thr Gln Leu Val Gln Ile Ser Thr Gly Leu Gln Ile Ser Arg
          35                  40                  45            
 Ser Lys Asn Gly Val Phe Thr Ser Ala Pro Tyr Leu Ser Leu Gln Glu
      50                  55                  60                
 Ile Leu Gly Leu Ala Ala Ser Asp Met Ser Trp Asn Pro Leu Pro Glu
  65                  70                  75                  80
 Ile Ala Val Phe Leu Asp Gly Leu Ser Thr Ser Ser Thr Thr Lys
                  85                  90                  95



      <210> 354
      <211> 74
      <212> PRT
      <213> Homo sapiens


      <400> 354
 Met Pro Lys Tyr Tyr Glu Asp Lys Pro Gln Gly Gly Ala Cys Ala Gly
   1               5                  10                  15    
 Leu Lys Glu Asp Leu Gly Ala Cys Leu Leu Gln Ser Asp Cys Val Val
              20                  25                  30        
 Gln Glu Gly Lys Ser Pro Arg Gln Cys Leu Lys Glu Gly Tyr Cys Asn
          35                  40                  45            
 Ser Leu Lys Tyr Ala Phe Phe Glu Cys Lys Arg Ser Val Leu Asp Asn
      50                  55                  60                
 Arg Ala Arg Phe Arg Gly Arg Lys Gly Tyr
  65                  70                



      <210> 355
      <211> 228
      <212> PRT
      <213> Homo sapiens


      <400> 355
 Met Ala Ala Ala Val Leu Gly Gln Leu Gly Ala Leu Trp Ile His Asn
   1               5                  10                  15    
 Leu Arg Ser Arg Gly Lys Leu Ala Leu Gly Val Leu Pro Gln Ser Tyr
              20                  25                  30        
 Ile His Thr Ser Ala Ser Leu Asp Ile Ser Arg Lys Trp Glu Lys Lys
          35                  40                  45            
 Asn Lys Ile Val Tyr Pro Pro Gln Leu Pro Gly Glu Pro Arg Arg Pro
      50                  55                  60                
 Ala Glu Ile Tyr His Cys Arg Arg Gln Ile Lys Tyr Ser Lys Asp Lys
  65                  70                  75                  80
 Met Trp Tyr Leu Ala Lys Leu Ile Arg Gly Met Ser Ile Asp Gln Ala
                  85                  90                  95    
 Leu Ala Gln Leu Glu Phe Asn Asp Lys Lys Gly Ala Lys Ile Ile Lys
             100                 105                 110        
 Glu Val Leu Leu Glu Ala Gln Asp Met Ala Val Arg Asp His Asn Val
         115                 120                 125            
 Glu Phe Arg Ser Asn Leu Tyr Ile Ala Glu Ser Thr Ser Gly Arg Gly
     130                 135                 140                
 Gln Cys Leu Asn Thr Ile Arg Tyr His Gly Arg Gly Arg Phe Gly Ile
 145                 150                 155                 160
 Met Glu Lys Val Tyr Cys His Tyr Phe Val Lys Leu Val Glu Gly Pro
                 165                 170                 175    
 Pro Pro Pro Pro Glu Pro Pro Lys Thr Ala Val Ala His Ala Lys Glu
             180                 185                 190        
 Tyr Ile Gln Gln Phe Ala Ala Gly Pro Ser Phe Thr Leu Tyr Asp Glu
         195                 200                 205            
 Glu Ile Gln Thr Pro Gln Cys Ile Tyr Phe Ala Ile Tyr Phe Leu Lys
     210                 215                 220                
 Ile Asn Lys Asn
 225            



      <210> 356
      <211> 552
      <212> PRT
      <213> Homo sapiens


      <400> 356
 Met Pro Pro Thr Phe Trp Ile Leu Phe Leu His Leu Ser Gly Asp Arg
   1               5                  10                  15    
 Ser Arg Leu Tyr Gly Ala Ala Tyr Glu Lys Pro Lys Phe Ile Thr Ala
              20                  25                  30        
 Ala Lys Gly Lys Val Gln Ala Val Gly Gly Ser Cys Lys Val Met Arg
          35                  40                  45            
 Leu Ala Ile Ser Pro Thr Ala Phe Ser His Leu Leu Ala Cys Ala Gln
      50                  55                  60                
 Gln Phe Arg Lys Gln Thr Gln Ala Gln Val Tyr Ser Glu Asp Met Ala
  65                  70                  75                  80
 Leu Asn Ile Gly Ser Glu Pro Glu Gly Leu Gln Val Glu Glu Lys Glu
                  85                  90                  95    
 Arg Pro Val Gln Arg Leu Ser Ser Val Leu Gly Pro Leu Glu Glu Leu
             100                 105                 110        
 Leu Gln Pro Leu Phe Pro Leu Leu Ser Leu Ser Lys Ala Arg Val Gln
         115                 120                 125            
 Thr Pro Ala Val Val Ala Asp Ser Gly Lys Ser Lys Gly Lys Asp Lys
     130                 135                 140                
 Glu Arg Lys Thr Ser Thr Gly Gln His Ser Thr Val Gln Pro Glu Val
 145                 150                 155                 160
 Ala Asp Lys Ile Val Leu Val Ala Asp Arg His Leu Leu Glu Leu Pro
                 165                 170                 175    
 Leu Glu Gly Leu Ser Val Phe Asp Glu Gly Thr Ile Ser Ser Val Ser
             180                 185                 190        
 Arg Glu Phe Ser Leu Gln Met Leu Trp Asn Arg Leu His Lys Glu Glu
         195                 200                 205            
 Thr Glu Gly Gly Val Lys Lys Glu Gly Arg Ser Arg Asp Pro Lys Lys
     210                 215                 220                
 Arg Ser Leu Ala Lys Lys Gly Arg Lys Gly Ser Ile Pro Arg Thr Ile
 225                 230                 235                 240
 Pro Pro Asp Cys Ile Ile Val Asp Ser Asp Asn Phe Lys Phe Val Val
                 245                 250                 255    
 Asp Pro Tyr Glu Glu Ala Gln Gly Pro Glu Met Leu Thr Pro Val Ser
             260                 265                 270        
 Ile Thr Gln Asp Ile Leu Glu Arg Phe Gln Asp Thr Phe Thr Ser Arg
         275                 280                 285            
 Trp Ala Gly His Leu Gly Ser Lys His Phe Pro Ser Gln Ala Gln Trp
     290                 295                 300                
 Glu Gln Ala Leu Gly Ser Cys Ser Gly Phe Phe Phe Tyr Gly Met Glu
 305                 310                 315                 320
 Ser Phe Leu Ser His Ile Leu Val Glu Arg Leu Val Ala Met Asn Leu
                 325                 330                 335    
 Gln Glu Cys Gln Val Ala Val Leu Leu Asp Leu Ala Arg Ser Tyr Gln
             340                 345                 350        
 Ser Leu Lys Arg His Met Glu Ser Val Glu His Arg Arg Ser Val Gly
         355                 360                 365            
 Arg Trp Glu Ala Asn Trp Arg Asn Gly Ala Ser Pro Ser Glu Asp Glu
     370                 375                 380                
 Trp Arg Arg Gly Gly Glu Pro Arg Arg Gly Phe Ser Asp Leu Glu Gly
 385                 390                 395                 400
 Gln Ala Ala Ala Ala Pro Lys Leu Arg Ala Pro Ser His His Ala Gln
                 405                 410                 415    
 Leu Gly Pro Val Trp Ala Ala Ala Pro Ser His Arg Val Val Gln Ala
             420                 425                 430        
 Trp Thr Cys Leu Pro Ser Ala Ala Gly Ala Pro Ala Leu Ala Ser Ala
         435                 440                 445            
 Leu Gly Ser Ala Pro Leu Pro Thr His Pro His Leu Pro Ala Pro Ile
     450                 455                 460                
 Pro Ser Ser Gln Leu Ala Leu Pro Phe Leu Gly Leu Ser Pro Ala Leu
 465                 470                 475                 480
 Gly Ala Ala Ser Ala Arg Asp Pro Pro Pro Ala Thr Ser Arg Lys Ala
                 485                 490                 495    
 Ala Ala Trp Thr Ser Ser Ser Ala Cys Leu Cys Ala Pro Trp Gly Leu
             500                 505                 510        
 Arg Arg Gly Trp Ser Cys Val Ser Ser Arg Gly Gln Asp Lys Gly Gly
         515                 520                 525            
 Leu Pro Leu Ala Ala Leu Val Leu Ser Cys Leu Asp Gln Lys Thr Ile
     530                 535                 540                
 Gln Thr Val Ser Leu Phe Leu Ile
 545                 550        



      <210> 357
      <211> 194
      <212> PRT
      <213> Homo sapiens


      <400> 357
 Met Lys Leu Ala Ser Gly Phe Leu Val Leu Trp Leu Ser Leu Gly Gly
   1               5                  10                  15    
 Gly Leu Ala Gln Ser Asp Thr Ser Pro Asp Thr Glu Glu Ser Tyr Ser
              20                  25                  30        
 Asp Trp Gly Leu Arg His Leu Arg Gly Ser Phe Glu Ser Val Asn Ser
          35                  40                  45            
 Tyr Phe Asp Ser Phe Leu Glu Leu Leu Gly Gly Lys Asn Gly Val Cys
      50                  55                  60                
 Gln Tyr Arg Cys Arg Tyr Gly Lys Ala Pro Met Pro Arg Pro Gly Tyr
  65                  70                  75                  80
 Lys Pro Gln Glu Pro Asn Gly Cys Gly Ser Tyr Phe Leu Gly Leu Lys
                  85                  90                  95    
 Val Pro Glu Ser Met Asp Leu Gly Ile Pro Ala Met Thr Lys Cys Cys
             100                 105                 110        
 Asn Gln Leu Asp Val Cys Tyr Asp Thr Cys Gly Ala Asn Lys Tyr Arg
         115                 120                 125            
 Cys Asp Ala Lys Phe Arg Trp Cys Leu His Ser Ile Cys Ser Asp Leu
     130                 135                 140                
 Lys Arg Ser Leu Gly Phe Val Ser Lys Val Glu Ala Cys Asp Ser Leu
 145                 150                 155                 160
 Val Asp Thr Val Phe Asn Thr Val Trp Thr Leu Gly Cys Arg Pro Phe
                 165                 170                 175    
 Met Asn Ser Gln Arg Ala Ala Cys Ile Cys Ala Glu Glu Glu Lys Glu
             180                 185                 190        
 Glu Leu
        



      <210> 358
      <211> 437
      <212> PRT
      <213> Homo sapiens


      <400> 358
 Met Ser Glu Glu Lys Asp Cys Gly Gly Gly Asp Ala Leu Ser Asn Gly
   1               5                  10                  15    
 Ile Lys Lys His Arg Thr Ser Leu Pro Ser Pro Met Phe Ser Arg Asn
              20                  25                  30        
 Asp Phe Ser Ile Trp Ser Ile Leu Arg Lys Cys Ile Gly Met Glu Leu
          35                  40                  45            
 Ser Lys Ile Thr Met Pro Val Ile Phe Asn Glu Pro Leu Ser Phe Leu
      50                  55                  60                
 Gln Arg Leu Thr Glu Tyr Met Glu His Thr Tyr Leu Ile His Lys Ala
  65                  70                  75                  80
 Ser Ser Leu Ser Asp Pro Val Glu Arg Met Gln Cys Val Ala Ala Phe
                  85                  90                  95    
 Ala Val Ser Ala Val Ala Ser Gln Trp Glu Arg Thr Gly Lys Pro Phe
             100                 105                 110        
 Asn Pro Leu Leu Gly Glu Thr Tyr Glu Leu Val Arg Asp Asp Leu Gly
         115                 120                 125            
 Phe Arg Leu Ile Ser Glu Gln Val Ser His His Pro Pro Ile Ser Ala
     130                 135                 140                
 Phe His Ala Glu Gly Leu Asn Asn Asp Phe Ile Phe His Gly Ser Ile
 145                 150                 155                 160
 Tyr Pro Lys Leu Lys Phe Trp Gly Lys Ser Val Glu Ala Glu Pro Lys
                 165                 170                 175    
 Gly Thr Ile Thr Leu Glu Leu Leu Glu His Asn Glu Ala Tyr Thr Trp
             180                 185                 190        
 Thr Asn Pro Thr Cys Cys Val His Asn Ile Ile Val Gly Lys Leu Trp
         195                 200                 205            
 Ile Glu Gln Tyr Gly Asn Val Glu Ile Ile Asn His Lys Thr Gly Asp
     210                 215                 220                
 Lys Cys Val Leu Asn Phe Lys Pro Cys Gly Leu Phe Gly Lys Glu Leu
 225                 230                 235                 240
 His Lys Val Glu Gly Tyr Ile Gln Asp Lys Ser Lys Lys Lys Leu Cys
                 245                 250                 255    
 Ala Leu Tyr Gly Lys Trp Thr Glu Cys Leu Tyr Ser Val Asp Pro Ala
             260                 265                 270        
 Thr Phe Asp Ala Tyr Lys Lys Asn Asp Lys Lys Asn Thr Glu Glu Lys
         275                 280                 285            
 Lys Asn Ser Lys Gln Met Ser Thr Ser Glu Glu Leu Asp Glu Met Pro
     290                 295                 300                
 Val Pro Asp Ser Glu Ser Val Phe Ile Ile Pro Gly Ser Val Leu Leu
 305                 310                 315                 320
 Trp Arg Ile Ala Pro Arg Pro Pro Asn Ser Ala Gln Met Tyr Asn Phe
                 325                 330                 335    
 Thr Ser Phe Ala Met Val Leu Asn Glu Val Asp Lys Asp Met Glu Ser
             340                 345                 350        
 Val Ile Pro Lys Thr Asp Cys Arg Leu Arg Pro Asp Ile Arg Ala Met
         355                 360                 365            
 Glu Asn Gly Glu Ile Asp Gln Ala Ser Glu Glu Lys Lys Arg Leu Glu
     370                 375                 380                
 Glu Lys Gln Arg Ala Ala Arg Lys Asn Arg Ser Lys Ser Glu Glu Asp
 385                 390                 395                 400
 Trp Lys Thr Arg Trp Phe His Gln Gly Pro Asn Pro Tyr Asn Gly Ala
                 405                 410                 415    
 Gln Asp Trp Ile Tyr Ser Gly Ser Tyr Trp Asp Arg Asn Tyr Phe Asn
             420                 425                 430        
 Leu Pro Asp Ile Tyr
         435        



      <210> 359
      <211> 124
      <212> PRT
      <213> Homo sapiens


      <400> 359
 Met Tyr Met Tyr Val Cys Val Tyr Ile Cys Val Tyr Met Tyr Thr His
   1               5                  10                  15    
 Thr His Thr His Ile Tyr Ile Tyr Ile His Thr His Thr His Ile Tyr
              20                  25                  30        
 Met Glu Arg Glu Arg Glu Thr Val Ser Cys Ser Val Ala Gln Ala Gly
          35                  40                  45            
 Val Gln Trp Tyr Asp Leu Gly Ser Leu Gln Pro Pro Pro Pro Arg Leu
      50                  55                  60                
 Lys Arg Phe Ser Cys Leu Ser Leu Pro Ser Ser Trp Asp Tyr Arg Cys
  65                  70                  75                  80
 Ala Pro Pro His Gln Ala Asn His Ser Ile His Phe Ile Gln Ser Phe
                  85                  90                  95    
 Leu Lys Arg Ser Met Asn His Phe Gly Phe Arg Glu Leu Ser Phe Phe
             100                 105                 110        
 Lys Lys Glu Thr Leu Lys Lys Lys Ser Leu Tyr Glu
         115                 120                



      <210> 360
      <211> 180
      <212> PRT
      <213> Homo sapiens


      <400> 360
 Met Ser Val Leu Arg Pro Leu Asp Lys Leu Pro Gly Leu Asn Thr Ala
   1               5                  10                  15    
 Thr Ile Leu Leu Val Gly Thr Glu Asp Ala Leu Leu Gln Gln Leu Ala
              20                  25                  30        
 Asp Ser Met Leu Lys Glu Asp Cys Ala Ser Glu Leu Lys Val His Leu
          35                  40                  45            
 Ala Lys Ser Leu Pro Leu Pro Ser Ser Val Asn Arg Pro Arg Ile Asp
      50                  55                  60                
 Leu Ile Val Phe Val Val Asn Leu His Ser Lys Tyr Ser Leu Gln Asn
  65                  70                  75                  80
 Thr Glu Glu Ser Leu Arg His Val Asp Ala Ser Phe Phe Leu Gly Lys
                  85                  90                  95    
 Val Cys Phe Leu Ala Thr Gly Ala Gly Arg Glu Ser His Cys Ser Ile
             100                 105                 110        
 His Arg His Thr Val Val Lys Leu Ala His Thr Tyr Gln Ser Pro Leu
         115                 120                 125            
 Leu Tyr Cys Asp Leu Glu Val Glu Gly Phe Arg Ala Thr Met Ala Gln
     130                 135                 140                
 Arg Leu Val Arg Val Leu Gln Ile Cys Ala Gly His Val Pro Gly Val
 145                 150                 155                 160
 Ser Ala Leu Asn Leu Leu Ser Leu Leu Arg Ser Ser Glu Gly Pro Ser
                 165                 170                 175    
 Leu Glu Asp Leu
             180



      <210> 361
      <211> 169
      <212> PRT
      <213> Homo sapiens


      <400> 361
 Met Glu Phe Asp Arg Leu Thr Ile Ala Gln Thr Gly Val Gln Trp Leu
   1               5                  10                  15    
 Phe Ile Ser Thr Ile Ile Ala His Cys Ser Leu Glu Leu Leu Gly Ser
              20                  25                  30        
 Ser Asn Pro Pro Thr Ser Ala Ser Gln Val Ala Gly Thr Thr Gly Val
          35                  40                  45            
 Cys His Ser Gly Gln Leu Ile Phe Ser Phe Leu Lys Asp Asp Ile Leu
      50                  55                  60                
 Leu Tyr Cys Pro Ser Ser His Lys Leu Leu Ala Ser Ser Asn Pro Leu
  65                  70                  75                  80
 Ala Ser Ala Ser Gln Val Ala Arg Ile Thr Gly Ala Gly His His Asp
                  85                  90                  95    
 Gln Gln Lys Glu Ile Phe Tyr Ile Asp Cys Met Met Lys Tyr Phe Glu
             100                 105                 110        
 Tyr Ile Glu Leu Asn Arg Phe Ser His Leu Phe Ile Cys Ala Val Phe
         115                 120                 125            
 Phe Leu Met Trp Leu Leu Glu Asn Leu Gln Leu Thr Ile Trp Val Thr
     130                 135                 140                
 Phe Val Thr Ser Ile Val Phe Leu Leu Gly Asn Ala Val Leu Asp Ser
 145                 150                 155                 160
 Pro Glu Arg Ile His Ile Phe Ile Phe
                 165                



      <210> 362
      <211> 176
      <212> PRT
      <213> Homo sapiens


      <400> 362
 Met Val Tyr Thr Leu Trp Ala Ala Val Trp Val Thr Trp Asn Val Phe
   1               5                  10                  15    
 Ile Ile Cys Phe Tyr Leu Glu Val Gly Gly Leu Leu Lys Asp Ser Glu
              20                  25                  30        
 Leu Leu Thr Phe Ser Leu Ser Arg His Arg Ser Trp Trp Arg Glu Arg
          35                  40                  45            
 Trp Pro Gly Cys Leu His Glu Glu Val Pro Ala Val Gly Leu Gly Ala
      50                  55                  60                
 Pro His Gly Gln Asp Leu Val Ser Gly Ala Gly Cys Ala Leu Glu Pro
  65                  70                  75                  80
 Ser Tyr Val Glu Ala Leu His Ser Cys Leu Gln Ile Leu Ile Ala Ala
                  85                  90                  95    
 Gln Asn Gln Asn Pro Arg Trp Leu Ala Pro Gln Arg Arg Arg Asn Pro
             100                 105                 110        
 Trp Trp Leu Leu Ala Gly Val Gly Trp Gly Gln Ser Phe Trp Ala Leu
         115                 120                 125            
 Ser Val Ala Ala Arg Trp Ser Ala Cys Leu Arg Arg Lys Arg Thr Ala
     130                 135                 140                
 Leu Ile Ser Leu Val Asp Leu Ile His Phe Leu Ser Thr Met Ser Met
 145                 150                 155                 160
 Lys Ser His Pro Val Ser Cys Pro Ser Arg Cys Thr Cys Leu Arg Lys
                 165                 170                 175    





      <210> 363
      <211> 160
      <212> PRT
      <213> Homo sapiens


      <400> 363
 Met Gln Cys Leu Ala Ser Gln Ala Ala Ala Ser Arg Asp Cys Phe Arg
   1               5                  10                  15    
 Arg Glu Pro Thr Leu Leu Thr Cys Ala Leu Ser Leu Gln Phe Cys Thr
              20                  25                  30        
 Glu Leu Asn Gln Pro Thr Leu Pro Asn Ile Arg Lys Trp Lys Gly Pro
          35                  40                  45            
 Arg Gly Cys Trp Lys Ala Val Val Ala Glu Lys Pro Ser Asn Gln Leu
      50                  55                  60                
 Gln Lys Val Pro Ser Ser Ala Lys Pro Gly Leu Ser Leu His Leu Ile
  65                  70                  75                  80
 Tyr Thr Tyr Phe Ser Pro Asn Gln Gly His Leu Lys Ile Ser Phe Ala
                  85                  90                  95    
 Asn Ile Pro Gly Ser Ile Leu Tyr Phe Cys Pro Ile Phe Lys Ser Leu
             100                 105                 110        
 Pro Phe Ile Ser Lys Cys Pro Gly Phe Arg Phe Thr Phe Arg Leu Val
         115                 120                 125            
 Met Asp Ser Cys Gln Glu Gly Asn Glu Ser Leu Arg Val Leu Gly Gly
     130                 135                 140                
 Glu Glu Gly Arg Lys Ala Thr Asn Gly Tyr Phe Cys Pro Leu Ser Phe
 145                 150                 155                 160





      <210> 364
      <211> 379
      <212> PRT
      <213> Homo sapiens


      <400> 364
 Met Tyr Asn Ile Lys Gln Ser Thr Asp Thr Lys Glu Ala Ala Ala Ile
   1               5                  10                  15    
 Glu Ala Arg Arg Asn Arg Glu Lys Glu Arg Gln Asn Arg Phe Phe Asn
              20                  25                  30        
 Val Arg Asn Arg Val Met Gly Val Asp Val Gln Ala Leu Asn Asn Gln
          35                  40                  45            
 Val Gly Asp Arg Lys Arg Arg Glu Ala Ala Glu Arg Ser Lys Glu Ala
      50                  55                  60                
 Ala Tyr Gly Thr Ser Gln Val Gln Tyr Asp Val Val Val Gln Met Leu
  65                  70                  75                  80
 Glu Lys Glu Glu Ala Asp Arg Thr Arg Gln Leu Ala Lys Lys Val Gln
                  85                  90                  95    
 Glu Phe Arg Glu Gln Lys Gln Gln Leu Lys Asn Gly Arg Glu Phe Ser
             100                 105                 110        
 Leu Trp Asp Pro Gly Gln Val Trp Lys Gly Leu Pro Thr Tyr Leu Ser
         115                 120                 125            
 Tyr Ser Asn Thr Tyr Pro Gly Pro Ala Ser Leu Gln Tyr Phe Ser Gly
     130                 135                 140                
 Glu Asp Leu Asp Arg Asp Thr Arg Leu Arg Met Gln Gln Gly Gln Phe
 145                 150                 155                 160
 Arg Tyr Asn Leu Glu Arg Gln Gln Gln Glu Gln Gln Gln Ala Lys Val
                 165                 170                 175    
 Asp Glu Asn Tyr Thr Asp Ala Leu Ser Asn Gln Leu Arg Leu Ala Met
             180                 185                 190        
 Asp Ala Gln Ala Thr His Leu Ala Arg Leu Glu Glu Ser Cys Arg Ala
         195                 200                 205            
 Ala Met Met Cys Ala Met Ala Asn Ala Asn Lys Ala Gln Ala Ala Val
     210                 215                 220                
 Gln Ala Gly Arg Gln Arg Cys Glu Arg Gln Arg Glu Gln Lys Ala Asn
 225                 230                 235                 240
 Leu Ala Glu Ile Gln His Gln Ser Thr Ser Asp Leu Leu Thr Glu Asn
                 245                 250                 255    
 Pro Gln Val Ala Gln His Pro Met Ala Pro Tyr Arg Val Leu Pro Tyr
             260                 265                 270        
 Cys Trp Lys Gly Met Thr Pro Glu Gln Gln Ala Ala Ile Arg Lys Glu
         275                 280                 285            
 Gln Glu Val Gln Arg Ser Lys Lys Gln Ala His Arg Gln Ala Glu Lys
     290                 295                 300                
 Thr Leu Asp Thr Glu Trp Lys Ser Gln Thr Met Ser Ser Ala Gln Ala
 305                 310                 315                 320
 Val Leu Glu Leu Glu Glu Gln Glu Arg Glu Leu Cys Ala Val Phe Gln
                 325                 330                 335    
 Arg Gly Leu Gly Ser Phe Asn Gln Gln Leu Ala Asn Glu Gln Lys Ala
             340                 345                 350        
 Gln Gln Asp Tyr Leu Asn Ser Val Ile Tyr Thr Asn Gln Pro Thr Ala
         355                 360                 365            
 Gln Tyr His Gln Gln Phe Asn Thr Ser Ser Arg
     370                 375                



      <210> 365
      <211> 85
      <212> PRT
      <213> Homo sapiens


      <400> 365
 Met Gln Lys Thr Val Ile Ser Ala Phe Arg Thr Glu Val Pro Gly Ser
   1               5                  10                  15    
 Ser His Trp Asp Trp Leu Asp Ser Glu Cys Ser Pro Lys Arg Ala Ser
              20                  25                  30        
 Arg Ser Arg Val Gly His Cys Leu Thr Trp Glu Ala Gln Gly Val Gly
          35                  40                  45            
 Glu Phe Pro Phe Pro Ala Lys Gly Ile His Gly Arg Leu Tyr Leu Glu
      50                  55                  60                
 Asn Gln Asp Thr Pro Ala Gln Ile Leu Arg Phe Ser Asn Gly Leu Ser
  65                  70                  75                  80
 Lys Trp His Leu Ala
                  85



      <210> 366
      <211> 1211
      <212> PRT
      <213> Homo sapiens


      <400> 366
 Met Ser Pro Ala Cys Val Val Ser Pro His Ala Thr Tyr Ser Thr Ser
   1               5                  10                  15    
 Ile Ile Pro Asn Ala Thr Leu Ser Ser Ser Ser Glu Val Ile Ala Ile
              20                  25                  30        
 Pro Thr Ala Gln Ser Ala Gly Gln Arg Glu Ser Lys Ser Ser Gly Ser
          35                  40                  45            
 Ser His Ala Arg Ile Lys Ser Arg Asp His Leu Ile Ser Arg His Ala
      50                  55                  60                
 Val Lys Gly Asp Pro Gln Ser Pro Gly Arg His Trp Asn Glu Gly His
  65                  70                  75                  80
 Ala Thr Ile Leu Ser Gln Asp Leu Asp Pro His Ser Pro Gly Glu Pro
                  85                  90                  95    
 Ala Leu Leu Ala Leu Cys Asp Ser Ala Val Pro Leu Asn Ala Pro Ala
             100                 105                 110        
 Asn Arg Glu Asn Gly Ser Gln Ala Met Pro Tyr Asn Cys Arg Asn Asn
         115                 120                 125            
 Leu Ala Phe Pro Ala His Pro Gln Asp Val Asp Gly Lys Ser Glu Ser
     130                 135                 140                
 Ser Tyr Ser Gly Gly Gly Gly His Ser Ser Ser Glu Pro Trp Glu Tyr
 145                 150                 155                 160
 Lys Ser Ser Gly Asn Gly Arg Ala Ser Pro Leu Lys Pro His Leu Ala
                 165                 170                 175    
 Thr Pro Gly Tyr Ser Thr Pro Thr Ser Asn Met Ser Ser Cys Ser Leu
             180                 185                 190        
 Asp Gln Thr Ser Asn Lys Glu Asp Ala Gly Ser Leu Tyr Ser Glu Asp
         195                 200                 205            
 His Asp Gly Tyr Cys Ala Ser Val His Thr Asp Ser Gly His Gly Ser
     210                 215                 220                
 Gly Asn Leu Cys Asn Ser Ser Asp Gly Phe Gly Asn Pro Arg His Ser
 225                 230                 235                 240
 Val Ile Asn Val Phe Val Gly Arg Ala Gln Lys Asn Gln Gly Asp Arg
                 245                 250                 255    
 Ser Asn Tyr Gln Asp Lys Ser Leu Ser Arg Asn Ile Ser Leu Lys Lys
             260                 265                 270        
 Ala Lys Lys Pro Pro Leu Pro Pro Ser Arg Thr Asp Ser Leu Arg Arg
         275                 280                 285            
 Ile Pro Lys Lys Ser Ser Gln Cys Asn Gly Gln Val Leu Asn Glu Ser
     290                 295                 300                
 Leu Ile Ala Thr Leu Gln His Ser Leu Gln Leu Ser Leu Pro Gly Lys
 305                 310                 315                 320
 Ser Gly Ser Ser Pro Ser Gln Ser Pro Cys Ser Asp Leu Glu Glu Pro
                 325                 330                 335    
 Trp Leu Pro Arg Ser Arg Ser Gln Ser Thr Val Ser Ala Gly Ser Ser
             340                 345                 350        
 Met Thr Ser Ala Thr Thr Pro Asn Val Tyr Ser Leu Cys Gly Ala Thr
         355                 360                 365            
 Pro Ser Gln Ser Asp Thr Ser Ser Val Lys Ser Glu Tyr Thr Asp Pro
     370                 375                 380                
 Trp Gly Tyr Tyr Ile Asp Tyr Thr Gly Met Gln Glu Asp Pro Gly Asn
 385                 390                 395                 400
 Pro Ala Gly Gly Cys Ser Thr Ser Ser Gly Val Pro Thr Gly Asn Gly
                 405                 410                 415    
 Pro Val Arg His Val Gln Glu Gly Ser Arg Ala Thr Met Pro Gln Val
             420                 425                 430        
 Pro Gly Gly Ser Val Lys Pro Lys Ile Met Ser Pro Glu Lys Ser His
         435                 440                 445            
 Arg Val Ile Ser Pro Ser Ser Gly Tyr Ser Ser Gln Ser Asn Thr Pro
     450                 455                 460                
 Thr Ala Leu Thr Pro Val Pro Val Phe Leu Lys Ser Val Ser Pro Ala
 465                 470                 475                 480
 Asn Gly Lys Gly Lys Pro Lys Pro Lys Val Pro Glu Arg Lys Ser Ser
                 485                 490                 495    
 Leu Ile Ser Ser Val Ser Ile Ser Ser Ser Ser Thr Ser Leu Ser Ser
             500                 505                 510        
 Ser Thr Ser Thr Glu Gly Ser Gly Thr Met Lys Lys Leu Asp Pro Ala
         515                 520                 525            
 Val Gly Ser Pro Pro Ala Pro Pro Pro Pro Pro Val Pro Ser Pro Pro
     530                 535                 540                
 Phe Pro Cys Pro Ala Asp Arg Ser Pro Phe Leu Pro Pro Pro Pro Pro
 545                 550                 555                 560
 Val Thr Asp Cys Ser Gln Gly Ser Pro Leu Pro His Ser Pro Val Phe
                 565                 570                 575    
 Pro Pro Pro Pro Pro Glu Ala Leu Ile Pro Phe Cys Ser Pro Pro Asp
             580                 585                 590        
 Trp Cys Leu Ser Pro Pro Arg Pro Ala Leu Ser Pro Ile Leu Pro Asp
         595                 600                 605            
 Ser Pro Val Ser Leu Pro Leu Pro Pro Pro Leu Leu Pro Ser Ser Glu
     610                 615                 620                
 Pro Pro Pro Ala Pro Pro Leu Asp Pro Lys Phe Met Lys Asp Thr Arg
 625                 630                 635                 640
 Pro Pro Phe Thr Asn Ser Gly Gln Pro Glu Ser Ser Arg Gly Ser Leu
                 645                 650                 655    
 Arg Pro Pro Ser Thr Lys Glu Glu Thr Ser Arg Pro Pro Met Pro Leu
             660                 665                 670        
 Ile Thr Thr Glu Ala Leu Gln Met Val Gln Leu Arg Pro Val Arg Lys
         675                 680                 685            
 Asn Ser Gly Ala Glu Ala Ala Gln Leu Ser Glu Arg Thr Ala Gln Glu
     690                 695                 700                
 Gln Arg Thr Pro Val Ala Pro Gln Tyr His Leu Lys Pro Ser Ala Phe
 705                 710                 715                 720
 Leu Lys Ser Arg Asn Ser Thr Asn Glu Met Glu Ser Glu Ser Gln Pro
                 725                 730                 735    
 Ala Ser Val Thr Ser Ser Leu Pro Thr Pro Ala Lys Ser Ser Ser Gln
             740                 745                 750        
 Gly Asp His Gly Ser Ala Ala Glu Arg Gly Gly Pro Val Ser Arg Ser
         755                 760                 765            
 Pro Gly Ala Pro Ser Ala Gly Glu Ala Glu Ala Arg Pro Ser Pro Ser
     770                 775                 780                
 Thr Thr Pro Leu Pro Asp Ser Ser Pro Ser Arg Lys Pro Pro Pro Ile
 785                 790                 795                 800
 Ser Lys Lys Pro Lys Leu Phe Leu Val Val Pro Pro Pro Gln Lys Asp
                 805                 810                 815    
 Phe Ala Val Glu Pro Ala Glu Asn Val Ser Glu Ala Leu Arg Ala Val
             820                 825                 830        
 Pro Ser Pro Thr Thr Gly Glu Glu Gly Ser Val His Ser Arg Glu Ala
         835                 840                 845            
 Lys Glu Ser Ser Ala Ala Gln Ala Gly Ser His Ala Thr His Pro Gly
     850                 855                 860                
 Thr Ser Val Leu Glu Gly Gly Ala Ala Gly Ser Met Ser Pro Ser Arg
 865                 870                 875                 880
 Val Glu Ala Asn Val Pro Met Val Gln Pro Asp Val Ser Pro Ala Pro
                 885                 890                 895    
 Lys Gln Glu Glu Pro Ala Glu Asn Ser Ala Asp Thr Gly Gly Asp Gly
             900                 905                 910        
 Glu Ser Cys Leu Ser Gln Gln Asp Gly Ala Ala Gly Val Pro Glu Thr
         915                 920                 925            
 Asn Ala Ala Gly Ser Ser Ser Glu Ala Cys Asp Phe Leu Lys Glu Asp
     930                 935                 940                
 Gly Asn Asp Glu Val Met Thr Pro Ser Arg Pro Arg Thr Thr Glu Asp
 945                 950                 955                 960
 Leu Phe Ala Ala Ile His Arg Ser Lys Arg Lys Val Leu Gly Arg Arg
                 965                 970                 975    
 Asp Ser Asp Asp Asp His Ser Arg Asn His Ser Pro Ser Pro Pro Val
             980                 985                 990        
 Thr Pro Thr Gly Ala Ala Pro Ser Leu Ala Ser Pro Lys Gln Val Gly
         995                1000                1005            
 Ser Ile Gln Arg Ser Ile Arg Lys Ser Ser Thr Ser Ser Asp Asn Phe
    1010                1015                1020                
 Lys Ala Leu Leu Leu Lys Lys Gly Ser Arg Ser Asp Thr Ser Ala Arg
1025                1030                1035                1040
 Met Ser Ala Ala Glu Met Leu Lys Asn Thr Asp Pro Arg Phe Gln Arg
                1045                1050                1055    
 Ser Arg Ser Glu Pro Ser Pro Asp Ala Pro Glu Ser Pro Ser Ser Cys
            1060                1065                1070        
 Ser Pro Ser Lys Asn Arg Arg Ala Gln Glu Glu Trp Ala Lys Asn Glu
        1075                1080                1085            
 Gly Leu Met Pro Arg Ser Leu Ser Phe Ser Gly Pro Arg Tyr Gly Arg
    1090                1095                1100                
 Ser Arg Thr Pro Pro Ser Ala Ala Ser Ser Arg Tyr Ser Met Arg Asn
1105                1110                1115                1120
 Arg Ile Gln Ser Ser Pro Met Thr Val Ile Ser Glu Gly Glu Gly Glu
                1125                1130                1135    
 Ala Val Glu Pro Val Asp Ser Ile Ala Arg Gly Ala Leu Gly Ala Ala
            1140                1145                1150        
 Glu Gly Cys Ser Leu Asp Gly Leu Ala Arg Glu Glu Met Asp Glu Gly
        1155                1160                1165            
 Gly Leu Leu Cys Gly Glu Gly Pro Ala Ala Ser Leu Gln Pro Gln Ala
    1170                1175                1180                
 Pro Gly Pro Val Asp Gly Thr Ala Ser Ala Glu Gly Arg Glu Pro Ser
1185                1190                1195                1200
 Pro Gln Cys Gly Gly Ser Leu Ser Glu Glu Ser
                1205                1210    



      <210> 367
      <211> 109
      <212> PRT
      <213> Homo sapiens


      <400> 367
 Met Leu Leu Glu Leu Ser Glu Glu His Lys Glu His Leu Ala Phe Leu
   1               5                  10                  15    
 Pro Gln Val Asp Ser Ala Gly Gln Arg Ala Trp Gly Arg Cys Ser Val
              20                  25                  30        
 Gly Trp Gly Gly Gly Gln Arg Gln Arg Leu Ala Leu Asn Ser Leu Leu
          35                  40                  45            
 Thr Phe Ile Ala Val Val Ala Glu Phe Gly Arg Ile Ala Val Glu Phe
      50                  55                  60                
 Leu Arg Arg Gly Ala Asn Pro Lys Ile Tyr Glu Gly Ala Ala Ser Lys
  65                  70                  75                  80
 Lys Gly Lys Gly Lys Ala Pro Gln Ala Ser Arg Ala Val Ala Ser His
                  85                  90                  95    
 Ser Leu Ser Pro Gly Arg Glu Thr Asp Tyr Cys Glu Ser
             100                 105                



      <210> 368
      <211> 79
      <212> PRT
      <213> Homo sapiens


      <400> 368
 Met Leu Leu Glu Leu Ser Glu Glu His Lys Glu His Leu Ala Phe Leu
   1               5                  10                  15    
 Pro Gln Val Asp Ser Ala Val Val Ala Glu Phe Gly Arg Ile Ala Val
              20                  25                  30        
 Glu Phe Leu Arg Arg Gly Ala Asn Pro Lys Ile Tyr Glu Gly Ala Ala
          35                  40                  45            
 Ser Lys Lys Gly Lys Gly Lys Ala Pro Gln Ala Ser Arg Ala Val Ala
      50                  55                  60                
 Ser His Ser Leu Ser Pro Gly Arg Glu Thr Asp Tyr Cys Glu Ser
  65                  70                  75                



      <210> 369
      <211> 361
      <212> PRT
      <213> Homo sapiens


      <400> 369
 Met Gly Gly Ala Val Ser Ala Gly Glu Asp Asn Asp Glu Leu Ile Asp
   1               5                  10                  15    
 Asn Leu Lys Glu Ala Gln Tyr Ile Arg Thr Glu Leu Val Glu Gln Ala
              20                  25                  30        
 Phe Arg Ala Ile Asp Arg Ala Asp Tyr Tyr Leu Glu Glu Phe Lys Glu
          35                  40                  45            
 Asn Ala Tyr Lys Asp Leu Ala Trp Lys His Gly Asn Ile His Leu Ser
      50                  55                  60                
 Ala Pro Cys Ile Tyr Ser Glu Val Met Glu Ala Leu Asp Leu Gln Pro
  65                  70                  75                  80
 Gly Leu Ser Phe Leu Asn Leu Gly Ser Gly Thr Gly Tyr Leu Ser Ser
                  85                  90                  95    
 Met Val Gly Leu Ile Leu Gly Pro Phe Gly Val Asn His Gly Val Glu
             100                 105                 110        
 Leu His Ser Asp Val Ile Glu Tyr Ala Lys Gln Lys Leu Asp Phe Phe
         115                 120                 125            
 Ile Arg Thr Ser Asp Ser Phe Asp Lys Phe Asp Phe Cys Glu Pro Ser
     130                 135                 140                
 Phe Val Thr Gly Asn Cys Leu Glu Ile Ser Pro Asp Cys Ser Gln Tyr
 145                 150                 155                 160
 Asp Arg Val Tyr Cys Gly Ala Gly Val Gln Lys Glu His Glu Glu Tyr
                 165                 170                 175    
 Met Lys Asn Leu Leu Lys Val Gly Gly Ile Leu Val Met Pro Leu Glu
             180                 185                 190        
 Glu Lys Leu Thr Lys Ile Thr Arg Thr Gly Pro Ser Ala Trp Glu Thr
         195                 200                 205            
 Lys Lys Ile Leu Ala Val Ser Phe Ala Pro Leu Ile Gln Pro Cys His
     210                 215                 220                
 Ser Glu Ser Gly Lys Ser Arg Leu Val Gln Leu Pro Pro Val Ala Val
 225                 230                 235                 240
 Arg Ser Leu Gln Asp Leu Ala Arg Ile Ala Ile Arg Gly Thr Ile Lys
                 245                 250                 255    
 Lys Ile Ile His Gln Glu Thr Val Ser Lys Asn Gly Asn Gly Leu Lys
             260                 265                 270        
 Asn Thr Pro Arg Phe Lys Arg Arg Arg Val Arg Arg Arg Arg Met Glu
         275                 280                 285            
 Thr Ile Val Phe Leu Asp Lys Glu Val Phe Ala Ser Arg Ile Ser Asn
     290                 295                 300                
 Pro Ser Asp Asp Asn Ser Cys Glu Asp Leu Glu Glu Glu Arg Arg Glu
 305                 310                 315                 320
 Glu Glu Glu Lys Thr Pro Pro Glu Thr Lys Pro Asp Pro Pro Val Asn
                 325                 330                 335    
 Phe Leu Arg Gln Lys Val Leu Ser Leu Pro Leu Pro Asp Pro Leu Lys
             340                 345                 350        
 Tyr Tyr Leu Leu Tyr Tyr Arg Glu Lys
         355                 360    



      <210> 370
      <211> 703
      <212> PRT
      <213> Homo sapiens


      <400> 370
 Met Arg His Glu Ile Glu Gly Thr Gly Leu Pro Gln Ala Gln Leu Leu
   1               5                  10                  15    
 Trp Arg Lys Val Pro Leu Asp Glu Arg Ile Val Phe Ser Gly Asn Leu
              20                  25                  30        
 Phe Gln His Gln Glu Asp Ser Lys Lys Trp Arg Asn Arg Phe Ser Leu
          35                  40                  45            
 Val Pro His Asn Tyr Gly Leu Val Leu Tyr Glu Asn Lys Ala Ala Tyr
      50                  55                  60                
 Glu Arg Gln Val Pro Pro Arg Ala Val Ile Asn Ser Ala Gly Tyr Lys
  65                  70                  75                  80
 Ile Leu Thr Ser Val Asp Gln Tyr Leu Glu Leu Ile Gly Asn Ser Leu
                  85                  90                  95    
 Pro Gly Thr Thr Ala Lys Ser Gly Ser Ala Pro Ile Leu Lys Cys Pro
             100                 105                 110        
 Thr Gln Phe Pro Leu Ile Leu Trp His Pro Tyr Ala Arg His Tyr Tyr
         115                 120                 125            
 Phe Cys Met Met Thr Glu Ala Glu Gln Asp Lys Trp Gln Ala Val Leu
     130                 135                 140                
 Gln Asp Cys Ile Arg His Cys Asn Asn Gly Ile Pro Glu Asp Ser Lys
 145                 150                 155                 160
 Val Glu Gly Pro Ala Phe Thr Asp Ala Ile Arg Met Tyr Arg Gln Ser
                 165                 170                 175    
 Lys Glu Leu Tyr Gly Thr Trp Glu Met Leu Cys Gly Asn Glu Val Gln
             180                 185                 190        
 Ile Leu Ser Asn Leu Val Met Glu Glu Leu Gly Pro Glu Leu Lys Ala
         195                 200                 205            
 Glu Leu Gly Pro Arg Leu Lys Gly Lys Pro Gln Glu Arg Gln Arg Gln
     210                 215                 220                
 Trp Ile Gln Ile Ser Asp Ala Val Tyr His Met Val Tyr Glu Gln Ala
 225                 230                 235                 240
 Lys Ala Arg Phe Glu Glu Val Leu Ser Lys Val Gln Gln Val Gln Pro
                 245                 250                 255    
 Ala Met Gln Ala Val Ile Arg Thr Asp Met Asp Gln Ile Ile Thr Ser
             260                 265                 270        
 Lys Glu His Leu Ala Ser Lys Ile Arg Ala Phe Ile Leu Pro Lys Ala
         275                 280                 285            
 Glu Val Cys Val Arg Asn His Val Gln Pro Tyr Ile Pro Ser Ile Leu
     290                 295                 300                
 Glu Ala Leu Met Val Pro Thr Ser Gln Gly Phe Thr Glu Val Arg Asp
 305                 310                 315                 320
 Val Phe Phe Lys Glu Val Thr Asp Met Asn Leu Asn Val Ile Asn Glu
                 325                 330                 335    
 Gly Gly Ile Asp Lys Leu Gly Glu Tyr Met Glu Lys Leu Ser Arg Leu
             340                 345                 350        
 Ala Tyr His Pro Leu Lys Met Gln Ser Cys Tyr Glu Lys Met Glu Ser
         355                 360                 365            
 Leu Arg Leu Asp Gly Leu Gln Gln Arg Phe Asp Val Ser Ser Thr Ser
     370                 375                 380                
 Val Phe Lys Gln Arg Ala Gln Ile His Met Arg Glu Gln Met Asp Asn
 385                 390                 395                 400
 Ala Val Tyr Thr Phe Glu Thr Leu Leu His Gln Glu Leu Gly Lys Gly
                 405                 410                 415    
 Pro Thr Lys Glu Glu Leu Cys Lys Ser Ile Gln Arg Val Leu Glu Arg
             420                 425                 430        
 Val Leu Lys Lys Tyr Asp Tyr Asp Ser Ser Ser Val Arg Lys Arg Phe
         435                 440                 445            
 Phe Arg Glu Ala Leu Leu Gln Ile Ser Ile Pro Phe Leu Leu Lys Lys
     450                 455                 460                
 Leu Ala Pro Thr Cys Lys Ser Glu Leu Pro Arg Phe Gln Glu Leu Ile
 465                 470                 475                 480
 Phe Glu Asp Phe Ala Arg Phe Ile Leu Val Glu Asn Thr Tyr Glu Glu
                 485                 490                 495    
 Val Val Leu Gln Thr Val Met Lys Asp Ile Leu Gln Ala Val Lys Glu
             500                 505                 510        
 Ala Ala Val Gln Arg Lys His Asn Leu Tyr Arg Asp Ser Met Val Met
         515                 520                 525            
 His Asn Ser Asp Pro Asn Leu His Leu Leu Ala Glu Gly Ala Pro Ile
     530                 535                 540                
 Asp Trp Gly Glu Glu Tyr Ser Asn Ser Gly Gly Gly Gly Ser Pro Ser
 545                 550                 555                 560
 Pro Ser Thr Pro Glu Ser Ala Thr Leu Ser Glu Lys Arg Arg Arg Ala
                 565                 570                 575    
 Lys Gln Val Val Ser Val Val Gln Asp Glu Glu Val Gly Leu Pro Phe
             580                 585                 590        
 Glu Ala Ser Pro Glu Ser Pro Pro Pro Ala Ser Pro Asp Gly Val Thr
         595                 600                 605            
 Glu Ile Arg Gly Leu Leu Ala Gln Gly Leu Arg Pro Glu Ser Pro Pro
     610                 615                 620                
 Pro Ala Gly Pro Leu Leu Asn Gly Ala Pro Ala Gly Glu Ser Pro Gln
 625                 630                 635                 640
 Pro Lys Ala Ala Pro Glu Ala Ser Ser Pro Pro Ala Ser Pro Leu Gln
                 645                 650                 655    
 His Leu Leu Pro Gly Lys Ala Val Asp Leu Gly Pro Pro Lys Pro Ser
             660                 665                 670        
 Asp Gln Glu Thr Gly Glu Gln Val Ser Ser Pro Ser Ser His Pro Ala
         675                 680                 685            
 Leu His Thr Thr Thr Glu Asp Ser Ala Gly Val Gln Thr Glu Phe
     690                 695                 700            



      <210> 371
      <211> 271
      <212> PRT
      <213> Homo sapiens


      <400> 371
 Met Phe Arg Asp Phe Gly Glu Pro Gly Pro Ser Ser Gly Asn Gly Gly
   1               5                  10                  15    
 Gly Tyr Gly Gly Pro Ala Gln Pro Pro Ala Ala Ala Gln Ala Ala Gln
              20                  25                  30        
 Gln Lys Phe His Leu Val Pro Ser Ile Asn Thr Met Ser Gly Ser Gln
          35                  40                  45            
 Glu Leu Gln Trp Met Val Gln Pro His Phe Leu Gly Pro Ser Ser Tyr
      50                  55                  60                
 Pro Arg Pro Leu Thr Tyr Pro Gln Tyr Ser Pro Pro Gln Pro Arg Pro
  65                  70                  75                  80
 Gly Val Ile Arg Ala Leu Gly Pro Pro Pro Gly Val Arg Arg Arg Pro
                  85                  90                  95    
 Cys Glu Gln Ile Ser Pro Glu Glu Glu Glu Arg Arg Arg Val Arg Arg
             100                 105                 110        
 Glu Arg Asn Lys Leu Ala Ala Ala Lys Cys Arg Asn Arg Arg Lys Glu
         115                 120                 125            
 Leu Thr Asp Phe Leu Gln Ala Glu Thr Asp Lys Leu Glu Asp Glu Lys
     130                 135                 140                
 Ser Gly Leu Gln Arg Glu Ile Glu Glu Leu Gln Lys Gln Lys Glu Arg
 145                 150                 155                 160
 Leu Glu Leu Val Leu Glu Ala His Arg Pro Ile Cys Lys Ile Pro Glu
                 165                 170                 175    
 Gly Ala Lys Glu Gly Asp Thr Gly Ser Thr Ser Gly Thr Ser Ser Pro
             180                 185                 190        
 Pro Ala Pro Cys Arg Pro Val Pro Cys Ile Ser Leu Ser Pro Gly Pro
         195                 200                 205            
 Val Leu Glu Pro Glu Ala Leu His Thr Pro Thr Leu Met Thr Thr Pro
     210                 215                 220                
 Ser Leu Thr Pro Phe Thr Pro Ser Leu Val Phe Thr Tyr Pro Ser Thr
 225                 230                 235                 240
 Pro Glu Pro Cys Ala Ser Ala His Arg Lys Ser Ser Ser Ser Ser Gly
                 245                 250                 255    
 Asp Pro Ser Ser Asp Pro Leu Gly Ser Pro Thr Leu Leu Ala Leu
             260                 265                 270    



      <210> 372
      <211> 1901
      <212> PRT
      <213> Homo sapiens


      <400> 372
 Met Ala Thr Phe Arg Asn Asn His Met Lys Thr Lys Ala Ser Val Arg
   1               5                  10                  15    
 Lys Ser Phe Ser Glu Asp Val Phe Gln Ser Val Lys Ser Leu Leu Gln
              20                  25                  30        
 Ser Gln Lys Glu Leu Cys Ser Val Thr Ala Glu Asp Cys Leu Gln Gln
          35                  40                  45            
 Asp Glu His Ala Asn Leu Thr Glu Val Thr Phe Leu Gly Phe Asn Glu
      50                  55                  60                
 Glu Thr Asp Ala Ala His Ile Gln Asp Leu Ala Ala Val Ser Leu Glu
  65                  70                  75                  80
 Leu Pro Asp Ile Leu Asn Ser Leu His Phe Cys Ser Leu Asn Glu Asn
                  85                  90                  95    
 Glu Ile Ile Cys Met Lys Asn Ile Asn Lys Pro Leu Asp Ile Ser Ser
             100                 105                 110        
 Asp Pro Leu Asn Gln Ser His Pro Ser Gly Met Leu Cys Val Met Arg
         115                 120                 125            
 Val Ser Pro Thr Ser Pro Arg Leu Arg Ile Asp Phe Ile Phe Ser Leu
     130                 135                 140                
 Leu Ser Lys Tyr Ala Thr Gly Ile Arg Tyr Thr Leu Asp Thr Phe Leu
 145                 150                 155                 160
 His Gln Lys His Gln Leu Glu Thr Thr Asp Glu Asp Asp Asp Asp Thr
                 165                 170                 175    
 Asn Gln Ser Val Ser Ser Ile Glu Asp Asp Phe Val Thr Ala Phe Glu
             180                 185                 190        
 His Leu Glu Glu Glu Glu Thr Ser Lys Pro Tyr Asn Asp Gly Met Asn
         195                 200                 205            
 Ile Thr Val Leu Arg Ser Gln Cys Asp Ala Ala Ser Gln Thr Val Thr
     210                 215                 220                
 Gly His His Leu Glu Thr His Asp Leu Lys Ile Leu Ile Ser Ser Gly
 225                 230                 235                 240
 Gln Gln Lys Ser Leu Ala Lys Pro Ser Thr Ser Ser Val Asn Val Leu
                 245                 250                 255    
 Gly His Lys Glu Leu Pro Ser Val Lys Thr Ser Val Thr Thr Ser Ile
             260                 265                 270        
 Ser Glu Pro Trp Thr Gln Arg Ser Phe Tyr Arg Ser Ser Asn Ala Ser
         275                 280                 285            
 Asp Lys Asp Ser Asp Leu Gln Lys Thr Phe Phe Ser Ser Ser Pro Ala
     290                 295                 300                
 Tyr Ser Ser Glu Ser Glu Cys Ser Ser Pro Ser Pro Val Ile Phe Leu
 305                 310                 315                 320
 Asp Glu Glu Gly Tyr Gln Lys Ser Leu Lys Ala Lys Leu Glu Leu Pro
                 325                 330                 335    
 Lys Ile Pro Val Met Lys Asp Asp Ile Glu Asp Ser Asp Ser Glu Val
             340                 345                 350        
 Ser Glu Phe Phe Asp Ser Phe Asp Gln Phe Asp Glu Leu Glu Gln Thr
         355                 360                 365            
 Leu Glu Thr Cys Leu Phe Asn Lys Asp Pro Val Ile Gly Lys Ser Ser
     370                 375                 380                
 Gln Arg Lys Gly His Lys His Gly Lys Ser Cys Met Asn Pro Gln Lys
 385                 390                 395                 400
 Phe Lys Phe Asp Arg Pro Ala Leu Pro Ala Asn Val Arg Lys Pro Thr
                 405                 410                 415    
 Pro Arg Lys Pro Glu Ser Pro Tyr Gly Asn Leu Cys Asp Ala Pro Asp
             420                 425                 430        
 Ser Pro Arg Pro Val Lys Ala Ser Arg Glu Asp Ser Gly Leu Phe Ser
         435                 440                 445            
 Pro Ile Arg Ser Ser Ala Phe Ser Pro Leu Gly Gly Cys Thr Pro Ala
     450                 455                 460                
 Glu Cys Phe Cys Gln Thr Asp Ile Gly Gly Asp Arg Ile His Glu Asn
 465                 470                 475                 480
 His Asp Ser Val Tyr Tyr Thr Tyr Glu Asp Tyr Ala Lys Ser Ile Ser
                 485                 490                 495    
 Cys Glu Val Leu Gly Ser Val Leu Arg Thr His His Thr Asn Thr Leu
             500                 505                 510        
 Ser Asn Ile Asn Ser Ile Lys His Gly Glu Asn Lys Thr Val Thr Phe
         515                 520                 525            
 Lys His Gly Asn Leu Asp Gln Lys Asn Lys Ser Lys Asn Lys Ser Leu
     530                 535                 540                
 Met Ile Lys Asn Ser Ile Gln Lys Phe Ala Ala Asp Leu Val Glu Lys
 545                 550                 555                 560
 Ser Phe Gly Ser Ala Phe Lys Asp Leu Gln Lys Gly Val Ser Ser Cys
                 565                 570                 575    
 Thr Asn Ala Leu Tyr His Leu Ala Ile Lys Leu Thr Ser Ser Val Leu
             580                 585                 590        
 Gln Met Ala Phe Asp Glu Leu Arg Arg Gln Arg Ala Phe Ser Leu Lys
         595                 600                 605            
 Glu Arg Ala Ile Ser Gly Leu Ala Asn Phe Leu Val Ser Glu Ala Leu
     610                 615                 620                
 Ser Asn Ala Leu Lys Asp Leu Gln Tyr Val Lys Lys Gln Ile Phe Thr
 625                 630                 635                 640
 Asn Thr Val Ala Arg Phe Ala Ala Asp Leu Ala Glu Glu Leu Val Phe
                 645                 650                 655    
 Glu Gly Ile Met Glu Val Cys Gln Phe Ser Tyr Pro Gln Thr Pro Ala
             660                 665                 670        
 Ser Pro Gln Cys Gly Ser Phe Asp Phe Glu Asp Lys Val Val Lys Leu
         675                 680                 685            
 Tyr Ala Lys Asp Leu Ser Glu Ser Val Ile Gln Glu Ala Phe Ile Glu
     690                 695                 700                
 Leu Ser Gln Val Asp Val Thr Phe Thr Thr Lys Ala Ala Val Ser Val
 705                 710                 715                 720
 Ser Thr Asp Asn Ile Lys Tyr Val Ser Ala Glu Ser Val Val Pro Ser
                 725                 730                 735    
 Thr Gln Ala Val Thr Phe Ser Pro Ser Phe His Asn Gln Ala Ile Met
             740                 745                 750        
 Val Thr Lys Pro Val Gln Glu Tyr Lys Lys Glu Tyr Thr Val Gln Gln
         755                 760                 765            
 Ala Leu Phe Cys Thr Ser Gly Ile Val Thr Ser Ile Pro Val Pro Leu
     770                 775                 780                
 Ala Gly Ser Ala Leu Leu Pro Tyr His Ile Ser Ser Thr Ala Cys Gln
 785                 790                 795                 800
 Ala Lys Ala His Leu Ser Ser Asp Asp Ser Asn Ser Asn Gly Asp Ser
                 805                 810                 815    
 Ala Gln Val His Ile Ala Thr Lys Asn Arg Glu Glu Lys Ala Ala Cys
             820                 825                 830        
 Leu Arg Asn Ile Cys Leu Pro Ser Glu His Asn Pro Gly Asn Gln Asn
         835                 840                 845            
 Asp Phe Lys Pro Thr Asn Asp Asp Ile Glu Met Gln Ser Ser Ser Lys
     850                 855                 860                
 Leu Pro Asn Asp Pro Ala Ile Ile Ser Asn Phe Ser Ala Ala Val Val
 865                 870                 875                 880
 His Thr Ile Val Asn Glu Thr Leu Glu Ser Met Thr Ser Leu Glu Val
                 885                 890                 895    
 Thr Lys Met Val Asp Glu Arg Thr Asp Tyr Leu Thr Lys Ser Leu Lys
             900                 905                 910        
 Glu Lys Thr Pro Pro Phe Ser His Cys Asp Gln Ala Val Leu Gln Cys
         915                 920                 925            
 Ser Glu Ala Ser Ser Asn Lys Asp Met Phe Ala Asp Arg Leu Ser Lys
     930                 935                 940                
 Ser Ile Ile Lys His Ser Ile Asp Lys Ser Lys Ser Val Ile Pro Asn
 945                 950                 955                 960
 Ile Asp Lys Asn Ala Val Tyr Lys Glu Ser Leu Pro Val Ser Gly Glu
                 965                 970                 975    
 Glu Ser Gln Leu Thr Pro Glu Lys Ser Pro Lys Phe Pro Asp Ser Gln
             980                 985                 990        
 Asn Gln Leu Thr His Cys Ser Leu Ser Ala Ala Lys Asp Cys Val Pro
         995                1000                1005            
 Glu Cys Lys Val Ser Met Val His Gly Ser Ser Leu Glu Thr Leu Pro
    1010                1015                1020                
 Ser Cys Pro Ala Val Thr Gly Gln Lys Ser Asp Leu Lys Glu Ser Ala
1025                1030                1035                1040
 Lys Asp Gln Pro Leu Lys Lys His Asn Leu Asn Ser Thr Ser Leu Glu
                1045                1050                1055    
 Ala Leu Ser Phe Gly Arg Glu Asn Pro Phe Pro His Ser His Thr Phe
            1060                1065                1070        
 Ser Ser Thr Ala Leu Thr Cys Val Asp Gly Leu His Val Glu Asp Lys
        1075                1080                1085            
 Gln Lys Val Arg Asp Arg Asn Val Ile Pro Asp Thr Pro Pro Ser Thr
    1090                1095                1100                
 Pro Leu Val Pro Ser Arg Ala Ser Ser Glu Trp Asp Ile Lys Lys Leu
1105                1110                1115                1120
 Thr Lys Lys Leu Lys Gly Glu Leu Ala Lys Glu Phe Ala Pro Ala Thr
                1125                1130                1135    
 Pro Pro Ser Thr Pro His Asn Ser Ser Val Gly Ser Leu Ser Glu Asn
            1140                1145                1150        
 Glu Gln Asn Thr Ile Glu Lys Glu Glu Phe Met Leu Lys Leu Met Arg
        1155                1160                1165            
 Ser Leu Ser Glu Glu Val Glu Ser Ser Glu Ser Gly Glu Leu Pro Glu
    1170                1175                1180                
 Val Asp Val Lys Ser Glu His Ser Gly Lys Lys Val Gln Phe Ala Glu
1185                1190                1195                1200
 Ala Leu Ala Thr His Ile Leu Ser Leu Ala Thr Glu Met Ala Ala Ser
                1205                1210                1215    
 His Leu Asp Asn Lys Ile Ile Gln Glu Pro Lys Val Lys Asn Pro Cys
            1220                1225                1230        
 Leu Asn Val Gln Ser Gln Arg Ser Val Ser Pro Thr Phe Leu Asn Pro
        1235                1240                1245            
 Ser Asp Glu Asn Leu Lys Thr Leu Cys Asn Phe Ala Gly Asp Leu Ala
    1250                1255                1260                
 Ala Glu Val Ile Thr Glu Ala Glu Lys Ile Ala Lys Val Arg Asn Cys
1265                1270                1275                1280
 Met Leu Phe Lys Gln Lys Lys Asn Ser Cys Tyr Ala Asp Gly Asp Glu
                1285                1290                1295    
 Asp Tyr Lys Val Glu Glu Lys Leu Asp Ile Glu Ala Val Val His Pro
            1300                1305                1310        
 Arg Glu Val Asp Pro Phe Ile Leu Ser Leu Pro Pro Ser Ser Cys Met
        1315                1320                1325            
 Ser Gly Leu Met Tyr Lys Tyr Pro Ser Cys Glu Ser Val Thr Asp Glu
    1330                1335                1340                
 Tyr Ala Gly His Leu Ile Gln Ile Leu Lys Gln Glu Gly Gly Asn Ser
1345                1350                1355                1360
 Glu Leu Ile Met Asp Gln Tyr Ala Asn Arg Leu Ala Tyr Arg Ser Val
                1365                1370                1375    
 Lys Ser Gly Leu Gln Glu Ala Ala Lys Thr Thr Lys Val Gln Cys Asn
            1380                1385                1390        
 Ser Arg Met Phe Pro Val Pro Ser Ser Gln Val Lys Thr Asn Lys Glu
        1395                1400                1405            
 Leu Leu Met Phe Ser Asn Lys Glu His His Gln Glu Ala Asp Lys Lys
    1410                1415                1420                
 Arg Gln Ser Lys Arg Asn Glu Gly Tyr Phe Cys Lys Asn Gln Thr Cys
1425                1430                1435                1440
 Glu Arg Thr Leu Asp Pro Tyr Arg Asn Glu Val Ser Gln Leu Tyr Ser
                1445                1450                1455    
 Phe Ser Thr Ser Leu Val His Ser Ile Thr Lys Asp Ala Lys Glu Glu
            1460                1465                1470        
 Leu Thr Ala Ser Leu Val Gly Leu Pro Lys Ser Leu Thr Asp Ser Cys
        1475                1480                1485            
 Leu Phe Glu Lys Ser Gly Tyr Glu Glu Asp Asn Glu Cys His Val Thr
    1490                1495                1500                
 Pro Glu Leu Pro Lys Ser Leu Gln Pro Ser Ser Gln Asn His Arg Phe
1505                1510                1515                1520
 Tyr His Ser Thr Gly Ser Leu Asn Gly Tyr Gly Cys Gly Asp Asn Val
                1525                1530                1535    
 Val Gln Ala Val Glu Gln Tyr Ala Lys Lys Val Val Asp Asp Thr Leu
            1540                1545                1550        
 Glu Leu Thr Leu Gly Ser Thr Val Phe Arg Val Ser Glu Thr Thr Lys
        1555                1560                1565            
 Ser Ala Asp Arg Val Thr Tyr Ala Glu Lys Leu Ser Pro Leu Thr Gly
    1570                1575                1580                
 Gln Ala Cys Arg Tyr Cys Asp Leu Lys Glu Leu His Asn Cys Thr Gly
1585                1590                1595                1600
 Asn Ser Ser Gln His Phe Phe Arg Gln Gly Ser Leu Ala Ser Ser Lys
                1605                1610                1615    
 Pro Ala Ser Asn Pro Lys Phe Ser Ser Arg Tyr Gln Lys Ser Arg Ile
            1620                1625                1630        
 Phe His Leu Ser Val Pro Gln Ile His Val Asn Leu Asp Lys Lys Ala
        1635                1640                1645            
 Val Leu Ala Glu Lys Ile Val Ala Glu Ala Ile Glu Lys Ala Glu Arg
    1650                1655                1660                
 Glu Leu Ser Ser Thr Ser Leu Ala Ala Asp Ser Gly Ile Gly Gln Glu
1665                1670                1675                1680
 Gly Ala Ser Phe Ala Glu Ser Leu Ala Thr Glu Thr Met Thr Ala Ala
                1685                1690                1695    
 Val Thr Asn Val Gly His Ala Val Ser Ser Ser Lys Glu Ile Glu Asp
            1700                1705                1710        
 Phe Gln Ser Thr Glu Ser Val Ser Ser Gln Gln Met Asn Leu Ser Ile
        1715                1720                1725            
 Gly Asp Asp Ser Thr Gly Ser Trp Ser Asn Leu Ser Phe Glu Asp Glu
    1730                1735                1740                
 His Gln Asp Glu Ser Ser Ser Phe His His Leu Ser Glu Ser Asn Gly
1745                1750                1755                1760
 Asn Ser Ser Ser Trp Ser Ser Leu Gly Leu Glu Gly Asp Leu Tyr Glu
                1765                1770                1775    
 Asp Asn Leu Ser Phe Pro Thr Ser Asp Ser Asp Gly Pro Asp Asp Lys
            1780                1785                1790        
 Asp Glu Glu His Glu Asp Glu Val Glu Gly Leu Gly Gln Asp Gly Lys
        1795                1800                1805            
 Thr Leu Leu Ile Thr Asn Ile Asp Met Glu Pro Cys Thr Val Asp Pro
    1810                1815                1820                
 Gln Leu Arg Ile Ile Leu Gln Trp Leu Ile Ala Ser Glu Ala Glu Val
1825                1830                1835                1840
 Ala Glu Leu Tyr Phe His Asp Ser Ala Asn Lys Glu Phe Met Leu Leu
                1845                1850                1855    
 Ser Lys Gln Leu Gln Glu Lys Gly Trp Lys Val Gly Asp Leu Leu Gln
            1860                1865                1870        
 Ala Val Leu Gln Tyr Tyr Glu Val Met Glu Lys Ala Ser Ser Glu Glu
        1875                1880                1885            
 Arg Cys Lys Ser Leu Phe Asp Trp Leu Leu Glu Asn Ala
    1890                1895                1900    



      <210> 373
      <211> 653
      <212> PRT
      <213> Homo sapiens


      <400> 373
 Met Ala Asp Thr Leu Pro Ser Glu Phe Asp Val Ile Val Ile Gly Thr
   1               5                  10                  15    
 Gly Leu Pro Glu Ser Ile Ile Ala Ala Ala Cys Ser Arg Ser Gly Arg
              20                  25                  30        
 Arg Val Leu His Val Asp Ser Arg Ser Tyr Tyr Gly Gly Asn Trp Ala
          35                  40                  45            
 Ser Phe Ser Phe Ser Gly Leu Leu Ser Trp Leu Lys Glu Tyr Gln Glu
      50                  55                  60                
 Asn Ser Asp Ile Val Ser Asp Ser Pro Val Trp Gln Asp Gln Ile Leu
  65                  70                  75                  80
 Glu Asn Glu Glu Ala Ile Ala Leu Ser Arg Lys Asp Lys Thr Ile Gln
                  85                  90                  95    
 His Val Glu Val Phe Cys Tyr Ala Ser Gln Asp Leu His Glu Asp Val
             100                 105                 110        
 Glu Glu Ala Gly Ala Leu Gln Lys Asn His Ala Leu Val Thr Ser Ala
         115                 120                 125            
 Asn Ser Thr Glu Ala Ala Asp Ser Ala Phe Leu Pro Thr Glu Asp Glu
     130                 135                 140                
 Ser Leu Ser Thr Met Ser Cys Glu Met Leu Thr Glu Gln Thr Pro Ser
 145                 150                 155                 160
 Ser Asp Pro Glu Asn Ala Leu Glu Val Asn Gly Ala Glu Val Thr Gly
                 165                 170                 175    
 Glu Lys Glu Asn His Cys Asp Asp Lys Thr Cys Val Pro Ser Thr Ser
             180                 185                 190        
 Ala Glu Asp Met Ser Glu Asn Val Pro Ile Ala Glu Asp Thr Thr Glu
         195                 200                 205            
 Gln Pro Lys Lys Asn Arg Ile Thr Tyr Ser Gln Ile Ile Lys Glu Gly
     210                 215                 220                
 Arg Arg Phe Asn Ile Asp Leu Val Ser Lys Leu Leu Tyr Ser Arg Gly
 225                 230                 235                 240
 Leu Leu Ile Asp Leu Leu Ile Lys Ser Asn Val Ser Arg Tyr Ala Glu
                 245                 250                 255    
 Phe Lys Asn Ile Thr Arg Ile Leu Ala Phe Arg Glu Gly Arg Val Glu
             260                 265                 270        
 Gln Val Pro Cys Ser Arg Ala Asp Val Phe Asn Ser Lys Gln Leu Thr
         275                 280                 285            
 Met Val Glu Lys Arg Met Leu Met Lys Phe Leu Thr Phe Cys Met Glu
     290                 295                 300                
 Tyr Glu Lys Tyr Pro Asp Glu Tyr Lys Gly Tyr Glu Glu Ile Thr Phe
 305                 310                 315                 320
 Tyr Glu Tyr Leu Lys Thr Gln Lys Leu Thr Pro Asn Leu Gln Tyr Ile
                 325                 330                 335    
 Val Met His Ser Ile Ala Met Thr Ser Glu Thr Ala Ser Ser Thr Ile
             340                 345                 350        
 Asp Gly Leu Lys Ala Thr Lys Asn Phe Leu His Cys Leu Gly Arg Tyr
         355                 360                 365            
 Gly Asn Thr Pro Phe Leu Phe Pro Leu Tyr Gly Gln Gly Glu Leu Pro
     370                 375                 380                
 Gln Cys Phe Cys Arg Met Cys Ala Val Phe Gly Gly Ile Tyr Cys Leu
 385                 390                 395                 400
 Arg His Ser Val Gln Cys Leu Val Val Asp Lys Glu Ser Arg Lys Cys
                 405                 410                 415    
 Lys Ala Ile Ile Asp Gln Phe Gly Gln Arg Ile Ile Ser Glu His Phe
             420                 425                 430        
 Leu Val Glu Asp Ser Tyr Phe Pro Glu Asn Met Cys Ser Arg Val Gln
         435                 440                 445            
 Tyr Arg Gln Ile Ser Arg Ala Val Leu Ile Thr Asp Arg Ser Val Leu
     450                 455                 460                
 Lys Thr Asp Ser Asp Gln Gln Ile Ser Ile Leu Thr Val Pro Ala Glu
 465                 470                 475                 480
 Glu Pro Gly Thr Phe Ala Val Arg Val Ile Glu Leu Cys Ser Ser Thr
                 485                 490                 495    
 Met Thr Cys Met Lys Gly Thr Tyr Leu Val His Leu Thr Cys Thr Ser
             500                 505                 510        
 Ser Lys Thr Ala Arg Glu Asp Leu Glu Ser Val Val Gln Lys Leu Phe
         515                 520                 525            
 Val Pro Tyr Thr Glu Met Glu Ile Glu Asn Glu Gln Val Glu Lys Pro
     530                 535                 540                
 Arg Ile Leu Trp Ala Leu Tyr Phe Asn Met Arg Asp Ser Ser Asp Ile
 545                 550                 555                 560
 Ser Arg Ser Cys Tyr Asn Asp Leu Pro Ser Asn Val Tyr Val Cys Ser
                 565                 570                 575    
 Gly Pro Asp Cys Gly Leu Gly Asn Asp Asn Ala Val Lys Gln Ala Glu
             580                 585                 590        
 Thr Leu Phe Gln Glu Ile Cys Pro Asn Glu Asp Phe Cys Pro Pro Pro
         595                 600                 605            
 Pro Asn Pro Glu Asp Ile Ile Leu Asp Gly Asp Ser Leu Gln Pro Glu
     610                 615                 620                
 Ala Ser Glu Ser Ser Ala Ile Pro Glu Ala Asn Ser Glu Thr Phe Lys
 625                 630                 635                 640
 Glu Ser Thr Asn Leu Gly Asn Leu Glu Glu Ser Ser Glu
                 645                 650            



      <210> 374
      <211> 558
      <212> PRT
      <213> Homo sapiens


      <400> 374
 Met Glu Leu Leu Asn Thr Val Leu Leu Tyr Ser Gln Asn Pro Arg Arg
   1               5                  10                  15    
 Arg Ser Arg Leu Arg Lys Arg Ala Ala Gly Leu Leu Ala Arg Leu Gly
              20                  25                  30        
 Thr Gly Gly Ser Val Ala Leu Pro Ala Thr Pro Gly Leu Pro Gly Pro
          35                  40                  45            
 Arg Gln Arg Arg Ser Thr Glu Gly Arg Ala Ser Ala Ala Ala Gly Pro
      50                  55                  60                
 Gly Ile Phe Ile Arg Phe Phe Val Ala Ser Thr Lys Leu Glu Arg Val
  65                  70                  75                  80
 Ser His Phe Leu Val Ile Ser Ser Asp Asp Leu Asp Gly Lys Thr Asp
                  85                  90                  95    
 Glu Pro Trp Glu Phe Phe Gln Asp Leu Val Thr Phe Asp Asp Val Ala
             100                 105                 110        
 Trp Tyr Leu Thr Thr Arg Glu Trp Phe Lys Leu Asp Pro Glu Gln Arg
         115                 120                 125            
 Ala Leu Glu Tyr Tyr Gly Asn Val Thr Ser Val Gly Val Pro Val Leu
     130                 135                 140                
 Asn Pro Ala Leu Val Pro His Leu Ala Gln Gly Gln Val Leu Leu Val
 145                 150                 155                 160
 Ser Asp Pro Ser Pro Asn Thr Asp Pro Ala Lys Tyr Ser Glu Ser Thr
                 165                 170                 175    
 Ser Ala Thr Arg His Gln Met Lys Gly Glu Asp Ala Gln Pro Gln Glu
             180                 185                 190        
 Met Ala Ser Thr Ser Phe Pro Arg Ala Ser Gly Pro Ser Pro Glu Phe
         195                 200                 205            
 Arg Gln His Gly Asp Ser Asp Gly Lys Arg Gly Ser Pro Gln Asn Leu
     210                 215                 220                
 Pro Ile Glu His His Phe Ala Cys Lys Glu Cys Gly Asp Thr Phe Arg
 225                 230                 235                 240
 Leu Lys Val Leu Leu Val Gln His Gln Arg Val His Ser Glu Glu Lys
                 245                 250                 255    
 Gly Trp Glu Cys Gly Asp Cys Gly Lys Val Phe Arg Gly Val Ala Glu
             260                 265                 270        
 Phe Asn Glu His Arg Lys Ser His Val Ala Ala Glu Pro Gln Pro Gly
         275                 280                 285            
 Pro Ser Arg Ala Leu Glu Asn Ala Ala Glu Lys Arg Glu Gln Met Glu
     290                 295                 300                
 Arg Glu Ala Lys Pro Phe Glu Cys Glu Glu Cys Gly Lys Arg Phe Lys
 305                 310                 315                 320
 Lys Asn Ala Gly Leu Ser Gln His Leu Arg Val His Ser Arg Glu Lys
                 325                 330                 335    
 Pro Phe Asp Cys Glu Glu Cys Gly Arg Ser Phe Lys Val Asn Thr His
             340                 345                 350        
 Leu Phe Arg His Gln Lys Leu His Thr Ser Glu Lys Pro Phe Ala Cys
         355                 360                 365            
 Lys Ala Cys Ser Arg Asp Phe Leu Asp Arg Gln Glu Leu Leu Lys His
     370                 375                 380                
 Gln Arg Met His Thr Gly His Leu Pro Phe Asp Cys Asp Asp Cys Gly
 385                 390                 395                 400
 Lys Ser Phe Arg Gly Val Asn Gly Leu Ala Glu His Gln Arg Ile His
                 405                 410                 415    
 Ser Gly Ala Lys Pro Tyr Gly Cys Pro His Cys Gly Lys Leu Phe Arg
             420                 425                 430        
 Arg Ser Ser Glu Leu Thr Lys His Arg Arg Ile His Thr Gly Glu Lys
         435                 440                 445            
 Pro Tyr Ala Cys Gly Gln Cys Gly Lys Ala Phe Arg Gln Ser Ser Ser
     450                 455                 460                
 Leu Leu Glu His Ala Arg Ile His Ser Gly Glu Arg Pro Tyr Ala Cys
 465                 470                 475                 480
 Gly Glu Cys Gly Lys Ala Phe Arg Gly Pro Ser Asp Leu Ile Lys His
                 485                 490                 495    
 Arg Arg Ile His Ser Gly Leu Lys Pro Tyr Glu Cys Asp Lys Cys Gly
             500                 505                 510        
 Lys Ala Phe Arg Arg Ser Ser Gly Leu Ser Arg His Arg Arg Ile His
         515                 520                 525            
 Ser Gly Ala Arg Arg Cys Glu Cys Ser Gln Cys Gly Arg Val Phe Lys
     530                 535                 540                
 Arg Arg Ser Ala Leu Gln Lys His Gln Pro Thr His His Glu
 545                 550                 555            



      <210> 375
      <211> 128
      <212> PRT
      <213> Homo sapiens


      <400> 375
 Met Gln Ile Phe Val Lys Thr Leu Thr Gly Lys Thr Ile Thr Leu Glu
   1               5                  10                  15    
 Val Glu Pro Ser Asp Thr Ile Glu Asn Val Lys Ala Lys Ile Gln Asp
              20                  25                  30        
 Lys Glu Gly Ile Pro Pro Asp Gln Gln Arg Leu Ile Phe Ala Gly Lys
          35                  40                  45            
 Gln Leu Glu Asp Gly Arg Thr Leu Ser Asp Tyr Asn Ile Gln Lys Glu
      50                  55                  60                
 Ser Thr Leu His Leu Val Leu Arg Leu Arg Gly Gly Ile Ile Glu Pro
  65                  70                  75                  80
 Ser Leu Arg Gln Leu Ala Gln Lys Tyr Asn Cys Asp Lys Met Ile Cys
                  85                  90                  95    
 Arg Lys Cys Tyr Ala Arg Leu His Pro Arg Ala Val Asn Cys Arg Lys
             100                 105                 110        
 Lys Lys Cys Gly His Thr Asn Asn Leu Arg Pro Lys Lys Lys Val Lys
         115                 120                 125            





      <210> 376
      <211> 75
      <212> PRT
      <213> Homo sapiens


      <400> 376
 Met Ala Pro Glu Val Leu Pro Lys Pro Arg Met Arg Gly Leu Leu Ala
   1               5                  10                  15    
 Arg Arg Leu Arg Asn His Met Ala Val Ala Phe Val Leu Ser Leu Gly
              20                  25                  30        
 Val Ala Ala Leu Tyr Lys Phe Arg Val Ala Asp Gln Arg Lys Lys Ala
          35                  40                  45            
 Tyr Ala Asp Phe Tyr Arg Asn Tyr Asp Val Met Lys Asp Phe Glu Glu
      50                  55                  60                
 Met Arg Lys Ala Gly Ile Phe Gln Ser Val Lys
  65                  70                  75



      <210> 377
      <211> 146
      <212> PRT
      <213> Homo sapiens


      <400> 377
 Met Ala Gly Glu Leu Thr Pro Glu Glu Glu Ala Gln Tyr Lys Lys Ala
   1               5                  10                  15    
 Phe Ser Ala Val Asp Thr Asp Gly Asn Gly Thr Ile Asn Ala Gln Glu
              20                  25                  30        
 Leu Gly Ala Ala Leu Lys Ala Thr Gly Lys Asn Leu Ser Glu Ala Gln
          35                  40                  45            
 Leu Arg Lys Leu Ile Ser Glu Val Asp Ser Asp Gly Asp Gly Glu Ile
      50                  55                  60                
 Ser Phe Gln Glu Phe Leu Thr Ala Ala Lys Lys Ala Arg Ala Gly Leu
  65                  70                  75                  80
 Glu Asp Leu Gln Val Ala Phe Arg Ala Phe Asp Gln Asp Gly Asp Gly
                  85                  90                  95    
 His Ile Thr Val Asp Glu Leu Arg Arg Ala Met Ala Gly Leu Gly Gln
             100                 105                 110        
 Pro Leu Pro Gln Glu Glu Leu Asp Ala Met Ile Arg Glu Ala Asp Val
         115                 120                 125            
 Asp Gln Asp Gly Arg Val Asn Tyr Glu Glu Phe Ala Arg Met Leu Ala
     130                 135                 140                
 Gln Glu
 145    



      <210> 378
      <211> 110
      <212> PRT
      <213> Homo sapiens


      <400> 378
 Met Ala Ala Val Val Ala Lys Arg Glu Gly Pro Pro Phe Ile Ser Glu
   1               5                  10                  15    
 Ala Ala Val Arg Gly Asn Ala Ala Val Leu Asp Tyr Cys Arg Thr Ser
              20                  25                  30        
 Val Ser Ala Leu Ser Gly Ala Thr Ala Gly Ile Leu Gly Leu Thr Gly
          35                  40                  45            
 Leu Tyr Gly Phe Ile Phe Tyr Leu Leu Ala Ser Val Leu Leu Ser Leu
      50                  55                  60                
 Leu Leu Ile Leu Lys Ala Gly Arg Arg Trp Asn Lys Tyr Phe Lys Ser
  65                  70                  75                  80
 Arg Arg Pro Leu Phe Thr Gly Gly Leu Ile Gly Gly Leu Phe Thr Tyr
                  85                  90                  95    
 Val Leu Phe Trp Thr Phe Leu Tyr Gly Met Val His Val Tyr
             100                 105                 110



      <210> 379
      <211> 121
      <212> PRT
      <213> Homo sapiens


      <400> 379
 Met Gly Lys Leu Leu Leu Thr Gly Ala Val Phe Val Leu Phe Cys Phe
   1               5                  10                  15    
 Phe Glu Thr Val Ser Leu Cys Arg Pro Gly Trp Ile Cys Asn Gly Val
              20                  25                  30        
 Ile Ser Ala His Cys Lys Leu His Leu Leu Gly Ser Ser Asn Ser Cys
          35                  40                  45            
 Ala Ser Ala Ser Gln Val Ala Gly Ile Thr Gly Ala Cys His His Ala
      50                  55                  60                
 Arg Leu Ile Phe Val Phe Leu Val Glu Thr Gly Phe His His Val Gly
  65                  70                  75                  80
 Gln Ala Gly Leu Lys Leu Leu Thr Ser Ser Asp Leu Pro Ala Ser Ala
                  85                  90                  95    
 Ser Gln Ser Ala Gly Ile Thr Gly Leu Ser His Arg Ala Trp Pro Asp
             100                 105                 110        
 Ser Ser Phe Glu Gly Ser Ser Ser Ser
         115                 120    



      <210> 380
      <211> 129
      <212> PRT
      <213> Homo sapiens


      <400> 380
 Met Leu Glu Cys Ser Gly Thr Ile Leu Ala His Cys Asn Leu Arg Leu
   1               5                  10                  15    
 Leu Gly Ser Ser Asp Ser Leu Ala Ser Ala Ser Arg Val Ala Gly Ile
              20                  25                  30        
 Thr Gly Met Cys His His Thr Gln Leu Ile Phe Phe Leu Phe Leu Val
          35                  40                  45            
 Glu Thr Gly Phe Cys Pro Val Asp Gln Ala Gly Leu Lys Leu Leu Thr
      50                  55                  60                
 Ser Gly Asp Leu Pro Ala Ser Ala Ser Gln Ser Ala Arg Ile Thr Gly
  65                  70                  75                  80
 Met Ser His Cys Ala Gln Pro Ser Val Ile Ser Leu Gln His Lys Phe
                  85                  90                  95    
 Ile Val Lys Glu Phe Glu Asn Glu Pro Tyr Leu Glu Thr Tyr Phe Gly
             100                 105                 110        
 Val Tyr Pro Trp Thr Phe Tyr Ile Leu Val Ala Thr Cys Lys Cys Thr
         115                 120                 125            
 Pro
    



      <210> 381
      <211> 261
      <212> PRT
      <213> Homo sapiens


      <400> 381
 Met Ser Asp Glu Glu Val Glu Gln Val Glu Glu Gln Tyr Glu Glu Glu
   1               5                  10                  15    
 Glu Glu Ala Gln Glu Glu Ala Ala Glu Val His Glu Glu Val His Glu
              20                  25                  30        
 Pro Glu Glu Val Gln Glu Glu Glu Lys Pro Arg Pro Lys Leu Thr Ala
          35                  40                  45            
 Pro Lys Ile Pro Glu Gly Glu Lys Val Asp Phe Asp Asp Ile Gln Lys
      50                  55                  60                
 Lys Arg Gln Asn Lys Asp Leu Met Glu Leu Gln Ala Leu Ile Asp Ser
  65                  70                  75                  80
 His Phe Glu Ala Arg Lys Lys Glu Glu Glu Glu Leu Val Ala Leu Lys
                  85                  90                  95    
 Glu Arg Ile Glu Lys Arg Arg Ala Glu Arg Ala Glu Gln Gln Arg Ile
             100                 105                 110        
 Arg Ala Glu Lys Glu Arg Glu Arg Gln Asn Arg Leu Ala Glu Glu Lys
         115                 120                 125            
 Ala Arg Arg Glu Glu Glu Asp Ala Lys Arg Arg Ala Glu Asp Asp Leu
     130                 135                 140                
 Lys Lys Lys Lys Ala Leu Ser Ser Met Gly Ala Asn Tyr Ser Ser Tyr
 145                 150                 155                 160
 Leu Ala Lys Ala Asp Gln Lys Arg Gly Lys Lys Gln Thr Ala Arg Glu
                 165                 170                 175    
 Met Lys Lys Lys Ile Leu Ala Glu Arg Arg Lys Pro Leu Asn Ile Asp
             180                 185                 190        
 His Leu Gly Glu Asp Lys Leu Arg Asp Lys Ala Lys Glu Leu Trp Glu
         195                 200                 205            
 Thr Leu His Gln Leu Glu Ile Asp Lys Phe Glu Phe Gly Glu Lys Leu
     210                 215                 220                
 Lys Arg Gln Lys Tyr Asp Ile Thr Thr Leu Arg Ser Arg Ile Asp Gln
 225                 230                 235                 240
 Ala Gln Lys His Ser Lys Lys Ala Gly Thr Pro Ala Lys Gly Lys Val
                 245                 250                 255    
 Gly Gly Arg Trp Lys
             260    



      <210> 382
      <211> 240
      <212> PRT
      <213> Homo sapiens


      <400> 382
 Met Ser Asp Glu Glu Val Glu Gln Val Glu Glu Gln Tyr Glu Glu Glu
   1               5                  10                  15    
 Glu Glu Ala Lys Pro Arg Pro Lys Leu Thr Ala Pro Lys Ile Pro Glu
              20                  25                  30        
 Gly Glu Lys Val Asp Phe Asp Asp Ile Gln Lys Lys Arg Gln Asn Lys
          35                  40                  45            
 Asp Leu Met Glu Leu Gln Ala Leu Ile Asp Ser His Phe Glu Ala Arg
      50                  55                  60                
 Lys Lys Glu Glu Glu Glu Leu Val Ala Leu Lys Glu Arg Ile Glu Lys
  65                  70                  75                  80
 Arg Arg Ala Glu Arg Ala Glu Gln Gln Arg Ile Arg Ala Glu Lys Glu
                  85                  90                  95    
 Arg Glu Arg Gln Asn Arg Leu Ala Glu Glu Lys Ala Arg Arg Glu Glu
             100                 105                 110        
 Glu Asp Ala Lys Arg Arg Ala Glu Asp Asp Leu Lys Lys Lys Lys Ala
         115                 120                 125            
 Leu Ser Ser Met Gly Ala Asn Tyr Ser Ser Tyr Leu Ala Lys Ala Asp
     130                 135                 140                
 Gln Lys Arg Gly Lys Lys Gln Thr Ala Arg Glu Met Lys Lys Lys Ile
 145                 150                 155                 160
 Leu Ala Glu Arg Arg Lys Pro Leu Asn Ile Asp His Leu Gly Glu Asp
                 165                 170                 175    
 Lys Leu Arg Asp Lys Ala Lys Glu Leu Trp Glu Thr Leu His Gln Leu
             180                 185                 190        
 Glu Ile Asp Lys Phe Glu Phe Gly Glu Lys Leu Lys Arg Gln Lys Tyr
         195                 200                 205            
 Asp Ile Thr Thr Leu Arg Ser Arg Ile Asp Gln Ala Gln Lys His Ser
     210                 215                 220                
 Lys Lys Ala Gly Thr Pro Ala Lys Gly Lys Val Gly Gly Arg Trp Lys
 225                 230                 235                 240





      <210> 383
      <211> 245
      <212> PRT
      <213> Homo sapiens


      <400> 383
 Met Ser Asp Glu Glu Val Glu Gln Val Glu Glu Gln Tyr Glu Glu Glu
   1               5                  10                  15    
 Glu Glu Ala Gln Glu Glu Glu Glu Lys Pro Arg Pro Lys Leu Thr Ala
              20                  25                  30        
 Pro Lys Ile Pro Glu Gly Glu Lys Val Asp Phe Asp Asp Ile Gln Lys
          35                  40                  45            
 Lys Arg Gln Asn Lys Asp Leu Met Glu Leu Gln Ala Leu Ile Asp Ser
      50                  55                  60                
 His Phe Glu Ala Arg Lys Lys Glu Glu Glu Glu Leu Val Ala Leu Lys
  65                  70                  75                  80
 Glu Arg Ile Glu Lys Arg Arg Ala Glu Arg Ala Glu Gln Gln Arg Ile
                  85                  90                  95    
 Arg Ala Glu Lys Glu Arg Glu Arg Gln Asn Arg Leu Ala Glu Glu Lys
             100                 105                 110        
 Ala Arg Arg Glu Glu Glu Asp Ala Lys Arg Arg Ala Glu Asp Asp Leu
         115                 120                 125            
 Lys Lys Lys Lys Ala Leu Ser Ser Met Gly Ala Asn Tyr Ser Ser Tyr
     130                 135                 140                
 Leu Ala Lys Ala Asp Gln Lys Arg Gly Lys Lys Gln Thr Ala Arg Glu
 145                 150                 155                 160
 Met Lys Lys Lys Ile Leu Ala Glu Arg Arg Lys Pro Leu Asn Ile Asp
                 165                 170                 175    
 His Leu Gly Glu Asp Lys Leu Arg Asp Lys Ala Lys Glu Leu Trp Glu
             180                 185                 190        
 Thr Leu His Gln Leu Glu Ile Asp Lys Phe Glu Phe Gly Glu Lys Leu
         195                 200                 205            
 Lys Arg Gln Lys Tyr Asp Ile Thr Thr Leu Arg Ser Arg Ile Asp Gln
     210                 215                 220                
 Ala Gln Lys His Ser Lys Lys Ala Gly Thr Pro Ala Lys Gly Lys Val
 225                 230                 235                 240
 Gly Gly Arg Trp Lys
                 245



      <210> 384
      <211> 503
      <212> PRT
      <213> Homo sapiens


      <400> 384
 Met Met Val Lys Gly Arg Leu Phe Val Pro Asp Arg Ile Asn Gly Thr
   1               5                  10                  15    
 Ala Asn Lys Met Asn Gly Ala Leu Asp His Ser Asp Gln Pro Asp Pro
              20                  25                  30        
 Asp Ala Ile Lys Met Phe Val Gly Gln Ile Pro Arg Ser Trp Ser Glu
          35                  40                  45            
 Lys Glu Leu Lys Glu Leu Phe Glu Pro Tyr Gly Ala Val Tyr Gln Ile
      50                  55                  60                
 Asn Val Leu Arg Asp Arg Ser Gln Asn Pro Pro Gln Ser Lys Gly Cys
  65                  70                  75                  80
 Cys Phe Val Thr Phe Tyr Thr Arg Lys Ala Ala Leu Glu Ala Gln Asn
                  85                  90                  95    
 Ala Leu His Asn Ile Lys Thr Leu Pro Gly Met His His Pro Ile Gln
             100                 105                 110        
 Met Lys Pro Ala Asp Ser Glu Lys Ser Asn Ala Val Glu Asp Arg Lys
         115                 120                 125            
 Leu Phe Ile Gly Met Val Ser Lys Lys Cys Asn Glu Asn Asp Ile Arg
     130                 135                 140                
 Val Met Phe Ser Pro Phe Gly Gln Ile Glu Glu Cys Arg Ile Leu Arg
 145                 150                 155                 160
 Gly Pro Asp Gly Leu Ser Arg Gly Cys Ala Phe Val Thr Phe Ser Thr
                 165                 170                 175    
 Arg Ala Met Ala Gln Asn Ala Ile Lys Ala Met His Gln Ser Gln Thr
             180                 185                 190        
 Met Glu Gly Cys Ser Ser Pro Ile Val Val Lys Phe Ala Asp Thr Gln
         195                 200                 205            
 Lys Asp Lys Glu Gln Arg Arg Leu Gln Gln Gln Leu Ala Gln Gln Met
     210                 215                 220                
 Gln Gln Leu Asn Thr Ala Thr Trp Gly Asn Leu Thr Gly Leu Gly Gly
 225                 230                 235                 240
 Leu Thr Pro Gln Tyr Leu Ala Leu Leu Gln Gln Ala Thr Ser Ser Ser
                 245                 250                 255    
 Asn Leu Gly Ala Phe Ser Gly Ile Gln Gln Met Ala Gly Met Asn Ala
             260                 265                 270        
 Leu Gln Leu Gln Asn Leu Ala Thr Leu Ala Ala Ala Ala Ala Ala Ala
         275                 280                 285            
 Gln Thr Ser Ala Thr Ser Thr Asn Ala Asn Pro Leu Ser Thr Thr Ser
     290                 295                 300                
 Ser Ala Leu Gly Ala Leu Thr Ser Pro Val Ala Ala Ser Thr Pro Asn
 305                 310                 315                 320
 Ser Thr Ala Gly Ala Ala Met Asn Ser Leu Thr Ser Leu Gly Thr Leu
                 325                 330                 335    
 Gln Gly Leu Ala Gly Ala Thr Val Gly Leu Asn Asn Ile Asn Ala Leu
             340                 345                 350        
 Ala Gly Met Ala Ala Leu Asn Gly Gly Leu Gly Ala Thr Gly Leu Thr
         355                 360                 365            
 Asn Gly Thr Ala Gly Thr Met Asp Ala Leu Thr Gln Ala Tyr Ser Gly
     370                 375                 380                
 Ile Gln Gln Tyr Ala Ala Ala Ala Leu Pro Thr Leu Tyr Ser Gln Ser
 385                 390                 395                 400
 Leu Leu Gln Gln Gln Ser Ala Ala Gly Ser Gln Lys Glu Gly Pro Glu
                 405                 410                 415    
 Gly Ala Asn Leu Phe Ile Tyr His Leu Pro Gln Glu Phe Gly Asp Gln
             420                 425                 430        
 Asp Ile Leu Gln Met Phe Met Pro Phe Gly Asn Val Ile Ser Ala Lys
         435                 440                 445            
 Val Phe Ile Asp Lys Gln Thr Asn Leu Ser Lys Cys Phe Gly Phe Val
     450                 455                 460                
 Ser Tyr Asp Asn Pro Val Ser Ala Gln Ala Ala Ile Gln Ala Met Asn
 465                 470                 475                 480
 Gly Phe Gln Ile Gly Met Lys Arg Leu Lys Val Gln Leu Lys Arg Ser
                 485                 490                 495    
 Lys Asn Asp Ser Lys Pro Tyr
             500            



      <210> 385
      <211> 205
      <212> PRT
      <213> Homo sapiens


      <400> 385
 Met Ala Ala Ser Thr Ala Ser His Arg Pro Ile Lys Gly Ile Leu Lys
   1               5                  10                  15    
 Asn Lys Thr Ser Thr Thr Ser Ser Met Val Ala Ser Ala Glu Gln Pro
              20                  25                  30        
 Arg Gly Asn Val Asp Glu Glu Leu Ser Lys Lys Ser Gln Lys Trp Asp
          35                  40                  45            
 Glu Met Asn Ile Leu Ala Thr Tyr His Pro Ala Asp Lys Asp Tyr Gly
      50                  55                  60                
 Leu Met Lys Ile Asp Glu Pro Ser Thr Pro Tyr His Ser Met Met Gly
  65                  70                  75                  80
 Asp Asp Glu Asp Ala Cys Ser Asp Thr Glu Ala Thr Glu Ala Met Ala
                  85                  90                  95    
 Pro Asp Ile Leu Ala Arg Lys Leu Ala Ala Ala Glu Gly Leu Glu Pro
             100                 105                 110        
 Lys Tyr Arg Ile Gln Glu Gln Glu Ser Ser Gly Glu Glu Asp Ser Asp
         115                 120                 125            
 Leu Ser Pro Glu Glu Arg Glu Lys Lys Arg Gln Phe Glu Met Lys Arg
     130                 135                 140                
 Lys Leu His Tyr Asn Glu Gly Leu Asn Ile Lys Leu Ala Arg Gln Leu
 145                 150                 155                 160
 Ile Ser Lys Asp Leu His Asp Asp Asp Glu Asp Glu Glu Met Leu Glu
                 165                 170                 175    
 Thr Ala Asp Gly Glu Ser Met Asn Thr Glu Glu Ser Asn Gln Gly Ser
             180                 185                 190        
 Thr Pro Ser Asp Gln Gln Gln Asn Lys Leu Arg Ser Ser
         195                 200                 205



      <210> 386
      <211> 108
      <212> PRT
      <213> Homo sapiens


      <400> 386
 Met Arg Gly Ala Gly Glu Ala Val Pro Pro Arg Gly Leu Arg Glu Lys
   1               5                  10                  15    
 Phe Pro Arg Ala Leu Phe Gly Trp Ala Gly Glu Arg Pro Ser Ala Leu
              20                  25                  30        
 Cys Ala Ser Asn Pro Pro Gln Leu Ser Cys Ser Gly Arg Gly Ala Arg
          35                  40                  45            
 Tyr Phe Arg Leu Gly Glu Val Leu Gly Thr Asp Val Gly Ser Ser Val
      50                  55                  60                
 Gly Asp Phe Ser Gly Phe Trp Pro Phe Gln Thr Leu Val Ile Val Phe
  65                  70                  75                  80
 Ser Val Gln Ser Ser Phe Gly Val Trp Gly Phe Pro Ser Ser Cys Ala
                  85                  90                  95    
 Arg His Arg Glu Ala Trp Pro Glu Gly Pro Val Ser
             100                 105            



      <210> 387
      <211> 372
      <212> PRT
      <213> Homo sapiens


      <400> 387
 Met Lys Thr Ala Ala Glu Gln Gln Lys Thr Leu Arg Glu Phe Val Val
   1               5                  10                  15    
 Val Met Gly Thr Glu Gln Asp Arg Ala Cys Phe Phe Leu Glu Ser Ala
              20                  25                  30        
 Thr Trp Asp Leu Gln Ile Ala Leu Ala Ser Phe Tyr Glu Asp Arg Gly
          35                  40                  45            
 Glu Glu Asp Ile Ile Thr Ile Ser Gln Ala Thr Pro Ser Ser Val Ser
      50                  55                  60                
 Arg Gly Thr Ala Pro Ser Asp Asn Arg Val Thr Ser Phe Arg Asp Leu
  65                  70                  75                  80
 Ile His Asp Gln Asp Glu Asp Glu Glu Glu Glu Glu Gly Gln Arg Phe
                  85                  90                  95    
 Tyr Ala Gly Gly Ser Glu Arg Ser Gly Gln Gln Ile Val Gly Pro Pro
             100                 105                 110        
 Arg Lys Lys Ser Pro Asn Glu Leu Val Asp Asp Leu Phe Lys Gly Ala
         115                 120                 125            
 Lys Glu His Gly Ala Val Ala Val Glu Arg Val Thr Lys Ser Pro Gly
     130                 135                 140                
 Glu Thr Ser Lys Pro Arg Pro Phe Ala Gly Gly Gly Tyr Arg Leu Gly
 145                 150                 155                 160
 Ala Ala Pro Glu Glu Glu Ser Ala Tyr Val Ala Gly Glu Lys Arg Gln
                 165                 170                 175    
 His Ser Ser Gln Asp Val His Val Val Leu Lys Leu Trp Lys Ser Gly
             180                 185                 190        
 Phe Ser Leu Asp Asn Gly Glu Leu Arg Ser Tyr Gln Asp Pro Ser Asn
         195                 200                 205            
 Ala Gln Phe Leu Glu Ser Ile Arg Arg Gly Glu Val Pro Ala Glu Leu
     210                 215                 220                
 Arg Arg Leu Ala His Gly Gly Gln Val Asn Leu Asp Met Glu Asp His
 225                 230                 235                 240
 Arg Asp Glu Asp Phe Val Lys Pro Lys Gly Ala Phe Lys Ala Phe Thr
                 245                 250                 255    
 Gly Glu Gly Gln Lys Leu Gly Ser Thr Ala Pro Gln Val Leu Ser Thr
             260                 265                 270        
 Ser Ser Pro Ala Gln Gln Ala Glu Asn Glu Ala Lys Ala Ser Ser Ser
         275                 280                 285            
 Ile Leu Ile Asp Glu Ser Glu Pro Thr Thr Asn Ile Gln Ile Arg Leu
     290                 295                 300                
 Ala Asp Gly Gly Arg Leu Val Gln Lys Phe Asn His Ser His Arg Ile
 305                 310                 315                 320
 Ser Asp Ile Arg Leu Phe Ile Val Asp Ala Arg Pro Ala Met Ala Ala
                 325                 330                 335    
 Thr Ser Phe Ile Leu Met Thr Thr Phe Pro Asn Lys Glu Leu Ala Asp
             340                 345                 350        
 Glu Ser Gln Thr Leu Lys Glu Ala Asn Leu Leu Asn Ala Val Ile Val
         355                 360                 365            
 Gln Arg Leu Thr
     370        



      <210> 388
      <211> 531
      <212> PRT
      <213> Homo sapiens


      <400> 388
 Met Asp Glu Glu Ser Leu Glu Ser Ala Leu Gln Thr Tyr Arg Ala Gln
   1               5                  10                  15    
 Leu Gln Gln Val Glu Leu Ala Leu Gly Ala Gly Leu Asp Ser Ser Glu
              20                  25                  30        
 Gln Ala Asp Leu Arg Gln Leu Gln Gly Asp Leu Lys Glu Leu Ile Glu
          35                  40                  45            
 Leu Thr Glu Ala Ser Leu Val Ser Val Arg Lys Ser Arg Leu Leu Ala
      50                  55                  60                
 Ala Leu Asp Glu Glu Arg Pro Gly Arg Gln Glu Asp Ala Glu Tyr Gln
  65                  70                  75                  80
 Ala Phe Arg Glu Ala Ile Thr Glu Ala Val Glu Ala Pro Ala Ala Ala
                  85                  90                  95    
 Arg Gly Ser Gly Ser Glu Thr Val Pro Lys Ala Glu Ala Gly Pro Glu
             100                 105                 110        
 Ser Ala Ala Gly Gly Gln Glu Glu Glu Glu Gly Glu Asp Glu Glu Glu
         115                 120                 125            
 Leu Ser Gly Thr Lys Val Ser Ala Pro Tyr Tyr Ser Ser Trp Gly Thr
     130                 135                 140                
 Leu Glu Tyr His Asn Ala Met Val Ala Gly Thr Glu Glu Ala Glu Asp
 145                 150                 155                 160
 Gly Ser Ala Gly Val Arg Val Leu Tyr Leu Tyr Pro Thr His Lys Ser
                 165                 170                 175    
 Leu Lys Pro Arg Pro Phe Phe Leu Glu Gly Lys Cys Arg Phe Lys Glu
             180                 185                 190        
 Asn Cys Arg Phe Ser His Gly Gln Val Gly Ser Leu Asp Glu Leu Arg
         195                 200                 205            
 Pro Phe Gln Asp Pro Asp Leu Ser Ser Leu Gln Ala Gly Ser Ala Cys
     210                 215                 220                
 Leu Ala Lys His Gln Asp Gly Leu Trp His Ala Ala Arg Ile Thr Asp
 225                 230                 235                 240
 Val Asp Asn Gly Tyr Tyr Thr Val Lys Phe Asp Ser Leu Leu Leu Arg
                 245                 250                 255    
 Glu Ala Val Val Glu Gly Asp Gly Ile Leu Pro Pro Leu Arg Thr Glu
             260                 265                 270        
 Ala Thr Glu Ser Asp Ser Asp Ser Asp Gly Thr Gly Asp Ser Ser Tyr
         275                 280                 285            
 Ala Arg Val Val Gly Ser Asp Ala Val Asp Ser Ala Gln Ser Ser Ala
     290                 295                 300                
 Leu Cys Pro Ser Leu Ala Val Val Gly Ser Asp Ala Val Asp Ser Gly
 305                 310                 315                 320
 Thr Cys Ser Ser Ala Phe Ala Gly Trp Glu Val His Thr Arg Gly Ile
                 325                 330                 335    
 Gly Ser Arg Leu Leu Thr Lys Met Gly Tyr Glu Phe Gly Lys Gly Leu
             340                 345                 350        
 Gly Arg His Ala Glu Gly Arg Val Glu Pro Ile His Ala Val Val Leu
         355                 360                 365            
 Pro Arg Gly Lys Ser Leu Asp Gln Cys Val Glu Thr Leu Gln Lys Gln
     370                 375                 380                
 Thr Arg Val Gly Lys Ala Gly Thr Asn Lys Pro Pro Arg Cys Arg Gly
 385                 390                 395                 400
 Arg Gly Ala Arg Pro Gly Gly Arg Pro Ala Pro Arg Asn Val Phe Asp
                 405                 410                 415    
 Phe Leu Asn Glu Lys Leu Gln Gly Gln Ala Pro Gly Ala Leu Glu Ala
             420                 425                 430        
 Gly Ala Ala Pro Ala Gly Arg Arg Ser Lys Asp Met Tyr His Ala Ser
         435                 440                 445            
 Lys Ser Ala Lys Arg Ala Leu Ser Leu Arg Leu Phe Gln Thr Glu Glu
     450                 455                 460                
 Lys Ile Glu Arg Thr Gln Arg Asp Ile Arg Ser Ile Gln Glu Ala Leu
 465                 470                 475                 480
 Ala Arg Asn Ala Gly Arg His Ser Val Ala Ser Ala Gln Leu Gln Glu
                 485                 490                 495    
 Lys Leu Ala Gly Ala Gln Arg Gln Leu Gly Gln Leu Arg Ala Gln Glu
             500                 505                 510        
 Ala Gly Leu Gln Gln Glu Gln Arg Lys Ala Asp Thr His Lys Lys Met
         515                 520                 525            
 Thr Glu Phe
     530    



      <210> 389
      <211> 75
      <212> PRT
      <213> Homo sapiens


      <400> 389
 Met Ala Gly Gln Glu Asp Pro Val Gln Arg Glu Ile His Gln Asp Trp
   1               5                  10                  15    
 Ala Asn Arg Glu Tyr Ile Glu Ile Ile Thr Ser Ser Ile Lys Lys Ile
              20                  25                  30        
 Ala Asp Phe Leu Asn Ser Phe Asp Met Ser Cys Arg Ser Arg Leu Ala
          35                  40                  45            
 Thr Leu Asn Glu Lys Leu Thr Ala Leu Glu Arg Arg Ile Glu Tyr Ile
      50                  55                  60                
 Glu Ala Arg Val Thr Lys Gly Glu Thr Leu Thr
  65                  70                  75



      <210> 390
      <211> 188
      <212> PRT
      <213> Homo sapiens


      <400> 390
 Met Pro Gly Thr Val Ala Thr Leu Arg Phe Gln Leu Leu Pro Pro Glu
   1               5                  10                  15    
 Pro Asp Asp Ala Phe Trp Gly Ala Pro Cys Glu Gln Pro Leu Glu Arg
              20                  25                  30        
 Arg Tyr Gln Ala Leu Pro Ala Leu Val Cys Ile Met Cys Cys Leu Phe
          35                  40                  45            
 Gly Val Val Tyr Cys Phe Phe Gly Tyr Arg Cys Phe Lys Ala Val Leu
      50                  55                  60                
 Phe Leu Thr Gly Leu Leu Phe Gly Ser Val Val Ile Phe Leu Leu Cys
  65                  70                  75                  80
 Tyr Arg Glu Arg Val Leu Glu Thr Gln Leu Ser Ala Gly Ala Ser Ala
                  85                  90                  95    
 Gly Ile Ala Leu Gly Ile Gly Leu Leu Cys Gly Leu Val Ala Met Leu
             100                 105                 110        
 Val Arg Ser Val Gly Leu Phe Leu Val Gly Leu Leu Leu Gly Leu Leu
         115                 120                 125            
 Leu Ala Ala Ala Ala Leu Leu Gly Ser Ala Pro Tyr Tyr Gln Pro Gly
     130                 135                 140                
 Ser Val Trp Gly Pro Leu Gly Leu Leu Pro Gly Gly Arg Pro Ala Leu
 145                 150                 155                 160
 Cys Pro Ala His Ser Ala Leu Ala Pro Pro Thr His His Pro Gly His
                 165                 170                 175    
 Arg Arg Asp Trp Cys Cys Ala Asp Arg His Cys Arg
             180                 185            



      <210> 391
      <211> 358
      <212> PRT
      <213> Homo sapiens


      <400> 391
 Met Met Glu Lys Tyr Glu Lys Ile Gly Lys Ile Gly Glu Gly Ser Tyr
   1               5                  10                  15    
 Gly Val Val Phe Lys Cys Arg Asn Arg Asp Thr Gly Gln Ile Val Ala
              20                  25                  30        
 Ile Lys Lys Phe Leu Glu Ser Glu Asp Asp Pro Val Ile Lys Lys Ile
          35                  40                  45            
 Ala Leu Arg Glu Ile Arg Met Leu Lys Gln Leu Lys His Pro Asn Leu
      50                  55                  60                
 Val Asn Leu Leu Glu Val Phe Arg Arg Lys Arg Arg Leu His Leu Val
  65                  70                  75                  80
 Phe Glu Tyr Cys Asp His Thr Val Leu His Glu Leu Asp Arg Tyr Gln
                  85                  90                  95    
 Arg Gly Val Pro Glu His Leu Val Lys Ser Ile Thr Trp Gln Thr Leu
             100                 105                 110        
 Gln Ala Val Asn Phe Cys His Lys His Asn Cys Ile His Arg Asp Val
         115                 120                 125            
 Lys Pro Glu Asn Ile Leu Ile Thr Lys His Ser Val Ile Lys Leu Cys
     130                 135                 140                
 Asp Phe Gly Phe Ala Arg Leu Leu Thr Gly Pro Ser Asp Tyr Tyr Thr
 145                 150                 155                 160
 Asp Tyr Val Ala Thr Arg Trp Tyr Arg Ser Pro Glu Leu Leu Val Gly
                 165                 170                 175    
 Asp Thr Gln Tyr Gly Pro Pro Val Asp Val Trp Ala Ile Gly Cys Val
             180                 185                 190        
 Phe Ala Glu Leu Leu Ser Gly Val Pro Leu Trp Pro Gly Lys Ser Asp
         195                 200                 205            
 Val Asp Gln Leu Tyr Leu Ile Arg Lys Thr Leu Gly Asp Leu Ile Pro
     210                 215                 220                
 Arg His Gln Gln Val Phe Ser Thr Asn Gln Tyr Phe Ser Gly Val Lys
 225                 230                 235                 240
 Ile Pro Asp Pro Glu Asp Met Glu Pro Leu Glu Leu Lys Phe Pro Asn
                 245                 250                 255    
 Ile Ser Tyr Pro Ala Leu Gly Leu Leu Lys Gly Cys Leu His Met Asp
             260                 265                 270        
 Pro Thr Glu Arg Leu Thr Cys Glu Gln Leu Leu His His Pro Tyr Phe
         275                 280                 285            
 Glu Asn Ile Arg Glu Ile Glu Asp Leu Ala Lys Glu His Asn Lys Pro
     290                 295                 300                
 Thr Arg Lys Thr Leu Arg Lys Ser Arg Lys His His Cys Phe Thr Glu
 305                 310                 315                 320
 Thr Ser Lys Leu Gln Tyr Leu Pro Gln Leu Thr Gly Ser Ser Ile Leu
                 325                 330                 335    
 Pro Ala Leu Asp Asn Lys Lys Tyr Tyr Cys Asp Thr Lys Lys Leu Asn
             340                 345                 350        
 Tyr Arg Phe Pro Asn Ile
         355            



      <210> 392
      <211> 447
      <212> PRT
      <213> Homo sapiens


      <400> 392
 Met Ile Ile Pro Ser Leu Glu Glu Leu Asp Ser Leu Lys Tyr Ser Asp
   1               5                  10                  15    
 Leu Gln Asn Leu Ala Lys Ser Leu Gly Leu Arg Ala Asn Leu Arg Ala
              20                  25                  30        
 Thr Lys Leu Leu Lys Ala Leu Lys Gly Tyr Ile Lys His Glu Ala Arg
          35                  40                  45            
 Lys Gly Asn Glu Asn Gln Asp Glu Ser Gln Thr Ser Ala Ser Ser Cys
      50                  55                  60                
 Asp Glu Thr Glu Ile Gln Ile Ser Asn Gln Glu Glu Ala Glu Arg Gln
  65                  70                  75                  80
 Pro Leu Gly His Val Thr Lys Thr Arg Arg Arg Cys Lys Thr Val Arg
                  85                  90                  95    
 Val Asp Pro Asp Ser Gln Gln Asn His Ser Glu Ile Lys Ile Ser Asn
             100                 105                 110        
 Pro Thr Glu Phe Gln Asn His Glu Lys Gln Glu Ser Gln Asp Leu Arg
         115                 120                 125            
 Ala Thr Ala Lys Val Pro Ser Pro Pro Asp Glu His Gln Glu Ala Glu
     130                 135                 140                
 Asn Ala Val Ser Ser Gly Lys Arg Gly Ile Asn Gly Asn Arg Asp Ser
 145                 150                 155                 160
 Lys Val Pro Ser Glu Gly Lys Lys Ser Leu Tyr Thr Asp Glu Ser Ser
                 165                 170                 175    
 Lys Pro Gly Lys Asn Lys Arg Thr Ala Ile Thr Thr Pro Asn Phe Lys
             180                 185                 190        
 Lys Leu His Glu Ala His Phe Lys Glu Met Glu Ser Ile Asp Gln Tyr
         195                 200                 205            
 Ile Glu Arg Lys Lys Lys His Phe Glu Glu His Asn Ser Met Asn Glu
     210                 215                 220                
 Leu Lys Gln Gln Pro Ile Asn Lys Gly Gly Val Arg Thr Pro Val Pro
 225                 230                 235                 240
 Pro Arg Gly Arg Leu Ser Val Ala Ser Thr Pro Ile Ser Gln Arg Arg
                 245                 250                 255    
 Ser Gln Gly Arg Ser Cys Gly Pro Ala Ser Gln Ser Thr Leu Gly Leu
             260                 265                 270        
 Lys Gly Ser Leu Lys Arg Ser Ala Ile Ser Ala Ala Lys Thr Gly Val
         275                 280                 285            
 Arg Phe Ser Ala Ala Thr Lys Asp Asn Glu His Lys Arg Ser Leu Thr
     290                 295                 300                
 Lys Thr Pro Ala Arg Lys Ser Ala His Val Thr Val Ser Gly Gly Thr
 305                 310                 315                 320
 Pro Lys Gly Glu Ala Val Leu Gly Thr His Lys Leu Lys Thr Ile Thr
                 325                 330                 335    
 Gly Asn Ser Ala Ala Val Ile Thr Pro Phe Lys Leu Thr Thr Glu Ala
             340                 345                 350        
 Thr Gln Thr Pro Val Ser Asn Lys Lys Pro Val Phe Asp Leu Lys Ala
         355                 360                 365            
 Ser Leu Ser Arg Pro Leu Asn Tyr Glu Pro His Lys Gly Lys Leu Lys
     370                 375                 380                
 Pro Trp Gly Gln Ser Lys Glu Asn Asn Tyr Leu Asn Gln His Val Asn
 385                 390                 395                 400
 Arg Ile Asn Phe Tyr Lys Lys Thr Tyr Lys Gln Pro His Leu Gln Thr
                 405                 410                 415    
 Lys Glu Glu Gln Arg Lys Lys Arg Glu Gln Glu Arg Lys Glu Lys Lys
             420                 425                 430        
 Ala Lys Val Leu Gly Met Arg Arg Gly Leu Ile Leu Ala Glu Asp
         435                 440                 445        



      <210> 393
      <211> 830
      <212> PRT
      <213> Homo sapiens


      <400> 393
 Met Arg His Leu Ser Thr Gly Thr Met Thr Gly Leu Ala Ile Gln Tyr
   1               5                  10                  15    
 Ala Leu Asn Ile Ala Phe Ser Glu Ala Glu Gly Ala Arg Pro Leu Arg
              20                  25                  30        
 Gln Asn Val Pro Arg Val Ile Met Ile Val Thr Asp Gly Arg Pro Gln
          35                  40                  45            
 Asp Ser Val Ala Glu Val Ala Ala Lys Ala Arg Asp Thr Gly Ile Leu
      50                  55                  60                
 Ile Phe Ala Ile Gly Val Gly Gln Val Asp Phe Asn Thr Leu Lys Ser
  65                  70                  75                  80
 Ile Gly Ser Glu Pro His Glu Asp His Val Phe Leu Val Ala Asn Phe
                  85                  90                  95    
 Ser Gln Ile Glu Thr Leu Thr Ser Val Phe Gln Lys Lys Leu Cys Thr
             100                 105                 110        
 Ala His Met Cys Ser Thr Leu Glu His Asn Cys Ala His Phe Cys Ile
         115                 120                 125            
 Asn Ile Pro Gly Ser Tyr Val Cys Arg Cys Lys Gln Gly Tyr Ile Leu
     130                 135                 140                
 Asn Ser Asp Gln Thr Thr Cys Arg Ile Gln Asp Leu Cys Ala Met Glu
 145                 150                 155                 160
 Asp His Asn Cys Glu Gln Leu Cys Val Asn Val Pro Gly Ser Phe Val
                 165                 170                 175    
 Cys Gln Cys Tyr Ser Gly Tyr Ala Leu Ala Glu Asp Gly Lys Arg Cys
             180                 185                 190        
 Val Ala Val Asp Tyr Cys Ala Ser Glu Asn His Gly Cys Glu His Glu
         195                 200                 205            
 Cys Val Asn Ala Asp Gly Ser Tyr Leu Cys Gln Cys His Glu Gly Phe
     210                 215                 220                
 Ala Leu Asn Pro Asp Lys Lys Thr Cys Thr Lys Ile Asp Tyr Cys Ala
 225                 230                 235                 240
 Ser Ser Asn His Gly Cys Gln His Glu Cys Val Asn Thr Asp Asp Ser
                 245                 250                 255    
 Tyr Ser Cys His Cys Leu Lys Gly Phe Thr Leu Asn Pro Asp Lys Lys
             260                 265                 270        
 Thr Cys Arg Arg Ile Asn Tyr Cys Ala Leu Asn Lys Pro Gly Cys Glu
         275                 280                 285            
 His Glu Cys Val Asn Met Glu Glu Ser Tyr Tyr Cys Arg Cys His Arg
     290                 295                 300                
 Gly Tyr Thr Leu Asp Pro Asn Gly Lys Thr Cys Ser Arg Val Asp His
 305                 310                 315                 320
 Cys Ala Gln Gln Asp His Gly Cys Glu Gln Leu Cys Leu Asn Thr Glu
                 325                 330                 335    
 Asp Ser Phe Val Cys Gln Cys Ser Glu Gly Phe Leu Ile Asn Glu Asp
             340                 345                 350        
 Leu Lys Thr Cys Ser Arg Val Asp Tyr Cys Leu Leu Ser Asp His Gly
         355                 360                 365            
 Cys Glu Tyr Ser Cys Val Asn Met Asp Arg Ser Phe Ala Cys Gln Cys
     370                 375                 380                
 Pro Glu Gly His Val Leu Arg Ser Asp Gly Lys Thr Cys Ala Lys Leu
 385                 390                 395                 400
 Asp Ser Cys Ala Leu Gly Asp His Gly Cys Glu His Ser Cys Val Ser
                 405                 410                 415    
 Ser Glu Asp Ser Phe Val Cys Gln Cys Phe Glu Gly Tyr Ile Leu Arg
             420                 425                 430        
 Glu Asp Gly Lys Thr Cys Arg Arg Lys Asp Val Cys Gln Ala Ile Asp
         435                 440                 445            
 His Gly Cys Glu His Ile Cys Val Asn Ser Asp Asp Ser Tyr Thr Cys
     450                 455                 460                
 Glu Cys Leu Glu Gly Phe Arg Leu Ala Glu Asp Gly Lys Arg Cys Arg
 465                 470                 475                 480
 Arg Lys Asp Val Cys Lys Ser Thr His His Gly Cys Glu His Ile Cys
                 485                 490                 495    
 Val Asn Asn Gly Asn Ser Tyr Ile Cys Lys Cys Ser Glu Gly Phe Val
             500                 505                 510        
 Leu Ala Glu Asp Gly Arg Arg Cys Lys Lys Cys Thr Glu Gly Pro Ile
         515                 520                 525            
 Asp Leu Val Phe Val Ile Asp Gly Ser Lys Ser Leu Gly Glu Glu Asn
     530                 535                 540                
 Phe Glu Val Val Lys Gln Phe Val Thr Gly Ile Ile Asp Ser Leu Thr
 545                 550                 555                 560
 Ile Ser Pro Lys Ala Ala Arg Val Gly Leu Leu Gln Tyr Ser Thr Gln
                 565                 570                 575    
 Val His Thr Glu Phe Thr Leu Arg Asn Phe Asn Ser Ala Lys Asp Met
             580                 585                 590        
 Lys Lys Ala Val Ala His Met Lys Tyr Met Gly Lys Gly Ser Met Thr
         595                 600                 605            
 Gly Leu Ala Leu Lys His Met Phe Glu Arg Ser Phe Thr Gln Gly Glu
     610                 615                 620                
 Gly Ala Arg Pro Leu Ser Thr Arg Val Pro Arg Ala Ala Ile Val Phe
 625                 630                 635                 640
 Thr Asp Gly Arg Ala Gln Asp Asp Val Ser Glu Trp Ala Ser Lys Ala
                 645                 650                 655    
 Lys Ala Asn Gly Ile Thr Met Tyr Ala Val Gly Val Gly Lys Ala Ile
             660                 665                 670        
 Glu Glu Glu Leu Gln Glu Ile Ala Ser Glu Pro Thr Asn Lys His Leu
         675                 680                 685            
 Phe Tyr Ala Glu Asp Phe Ser Thr Met Asp Glu Ile Ser Glu Lys Leu
     690                 695                 700                
 Lys Lys Gly Ile Cys Glu Ala Leu Glu Asp Ser Asp Gly Arg Gln Asp
 705                 710                 715                 720
 Ser Pro Ala Gly Glu Leu Pro Lys Thr Val Gln Gln Pro Thr Glu Ser
                 725                 730                 735    
 Glu Pro Val Thr Ile Asn Ile Gln Asp Leu Leu Ser Cys Ser Asn Phe
             740                 745                 750        
 Ala Val Gln His Arg Tyr Leu Phe Glu Glu Asp Asn Leu Leu Arg Ser
         755                 760                 765            
 Thr Gln Lys Leu Ser His Ser Thr Lys Pro Ser Gly Ser Pro Leu Glu
     770                 775                 780                
 Glu Lys His Asp Gln Cys Lys Cys Glu Asn Leu Ile Met Phe Gln Asn
 785                 790                 795                 800
 Leu Ala Asn Glu Glu Val Arg Lys Leu Thr Gln Arg Leu Glu Glu Met
                 805                 810                 815    
 Thr Gln Arg Met Glu Ala Leu Glu Asn Arg Leu Arg Tyr Arg
             820                 825                 830



      <210> 394
      <211> 811
      <212> PRT
      <213> Homo sapiens


      <400> 394
 Met Arg His Leu Ser Thr Gly Thr Met Thr Gly Leu Ala Ile Gln Tyr
   1               5                  10                  15    
 Ala Leu Asn Ile Ala Phe Ser Glu Ala Glu Gly Ala Arg Pro Leu Arg
              20                  25                  30        
 Gln Asn Val Pro Arg Val Ile Met Ile Val Thr Asp Gly Arg Pro Gln
          35                  40                  45            
 Asp Ser Val Ala Glu Val Ala Ala Lys Ala Arg Asp Thr Gly Ile Leu
      50                  55                  60                
 Ile Phe Ala Ile Gly Val Gly Gln Val Asp Phe Asn Thr Leu Lys Ser
  65                  70                  75                  80
 Ile Gly Ser Glu Pro His Glu Asp His Val Phe Leu Val Ala Asn Phe
                  85                  90                  95    
 Ser Gln Ile Glu Thr Leu Thr Ser Val Phe Gln Lys Lys Leu Cys Thr
             100                 105                 110        
 Ala His Met Cys Ser Thr Leu Glu His Asn Cys Ala His Phe Cys Ile
         115                 120                 125            
 Asn Ile Pro Gly Ser Tyr Val Cys Arg Cys Lys Gln Gly Tyr Ile Leu
     130                 135                 140                
 Asn Ser Asp Gln Thr Thr Cys Arg Ile Gln Asp Leu Cys Ala Met Glu
 145                 150                 155                 160
 Asp His Asn Cys Glu Gln Leu Cys Val Asn Val Pro Gly Ser Phe Val
                 165                 170                 175    
 Cys Gln Cys Tyr Ser Gly Tyr Ala Leu Ala Glu Asp Gly Lys Arg Cys
             180                 185                 190        
 Val Ala Val Asp Tyr Cys Ala Ser Glu Asn His Gly Cys Glu His Glu
         195                 200                 205            
 Cys Val Asn Ala Asp Gly Ser Tyr Leu Cys Gln Cys His Glu Gly Phe
     210                 215                 220                
 Ala Leu Asn Pro Asp Lys Lys Thr Cys Thr Lys Ile Asp Tyr Cys Ala
 225                 230                 235                 240
 Ser Ser Asn His Gly Cys Gln His Glu Cys Val Asn Thr Asp Asp Ser
                 245                 250                 255    
 Tyr Ser Cys His Cys Leu Lys Gly Phe Thr Leu Asn Pro Asp Lys Lys
             260                 265                 270        
 Thr Cys Arg Arg Ile Asn Tyr Cys Ala Leu Asn Lys Pro Gly Cys Glu
         275                 280                 285            
 His Glu Cys Val Asn Met Glu Glu Ser Tyr Tyr Cys Arg Cys His Arg
     290                 295                 300                
 Gly Tyr Thr Leu Asp Pro Asn Gly Lys Thr Cys Ser Arg Val Asp His
 305                 310                 315                 320
 Cys Ala Gln Gln Asp His Gly Cys Glu Gln Leu Cys Leu Asn Thr Glu
                 325                 330                 335    
 Asp Ser Phe Val Cys Gln Cys Ser Glu Gly Phe Leu Ile Asn Glu Asp
             340                 345                 350        
 Leu Lys Thr Cys Ser Arg Val Asp Tyr Cys Leu Leu Ser Asp His Gly
         355                 360                 365            
 Cys Glu Tyr Ser Cys Val Asn Met Asp Arg Ser Phe Ala Cys Gln Cys
     370                 375                 380                
 Pro Glu Gly His Val Leu Arg Ser Asp Gly Lys Thr Cys Ala Lys Leu
 385                 390                 395                 400
 Asp Ser Cys Ala Leu Gly Asp His Gly Cys Glu His Ser Cys Val Ser
                 405                 410                 415    
 Ser Glu Asp Ser Phe Val Cys Gln Cys Phe Glu Gly Tyr Ile Leu Arg
             420                 425                 430        
 Glu Asp Gly Lys Thr Cys Arg Arg Lys Asp Val Cys Gln Ala Ile Asp
         435                 440                 445            
 His Gly Cys Glu His Ile Cys Val Asn Ser Asp Asp Ser Tyr Thr Cys
     450                 455                 460                
 Glu Cys Leu Glu Gly Phe Arg Leu Ala Glu Asp Gly Lys Arg Cys Arg
 465                 470                 475                 480
 Arg Lys Asp Val Cys Lys Ser Thr His His Gly Cys Glu His Ile Cys
                 485                 490                 495    
 Val Asn Asn Gly Asn Ser Tyr Ile Cys Lys Cys Ser Glu Gly Phe Val
             500                 505                 510        
 Leu Ala Glu Asp Gly Arg Arg Cys Lys Lys Cys Thr Glu Gly Pro Ile
         515                 520                 525            
 Asp Leu Val Phe Val Ile Asp Gly Ser Lys Ser Leu Gly Glu Glu Asn
     530                 535                 540                
 Phe Glu Val Val Lys Gln Phe Val Thr Gly Ile Ile Asp Ser Leu Thr
 545                 550                 555                 560
 Ile Ser Pro Lys Ala Ala Arg Val Gly Leu Leu Gln Tyr Ser Thr Gln
                 565                 570                 575    
 Val His Thr Glu Phe Thr Leu Arg Asn Phe Asn Ser Ala Lys Asp Met
             580                 585                 590        
 Lys Lys Ala Val Ala His Met Lys Tyr Met Gly Lys Gly Ser Met Thr
         595                 600                 605            
 Gly Leu Ala Leu Lys His Met Phe Glu Arg Ser Phe Thr Gln Gly Glu
     610                 615                 620                
 Gly Ala Arg Pro Leu Ser Thr Arg Val Pro Arg Ala Ala Ile Val Phe
 625                 630                 635                 640
 Thr Asp Gly Arg Ala Gln Asp Asp Val Ser Glu Trp Ala Ser Lys Ala
                 645                 650                 655    
 Lys Ala Asn Gly Ile Thr Met Tyr Ala Val Gly Val Gly Lys Ala Ile
             660                 665                 670        
 Glu Glu Glu Leu Gln Glu Ile Ala Ser Glu Pro Thr Asn Lys His Leu
         675                 680                 685            
 Phe Tyr Ala Glu Asp Phe Ser Thr Met Asp Glu Ile Ser Glu Lys Leu
     690                 695                 700                
 Lys Lys Gly Ile Cys Glu Ala Leu Glu Asp Ser Asp Gly Arg Gln Asp
 705                 710                 715                 720
 Ser Pro Ala Gly Glu Leu Pro Lys Thr Val Gln Gln Pro Thr Val Gln
                 725                 730                 735    
 His Arg Tyr Leu Phe Glu Glu Asp Asn Leu Leu Arg Ser Thr Gln Lys
             740                 745                 750        
 Leu Ser His Ser Thr Lys Pro Ser Gly Ser Pro Leu Glu Glu Lys His
         755                 760                 765            
 Asp Gln Cys Lys Cys Glu Asn Leu Ile Met Phe Gln Asn Leu Ala Asn
     770                 775                 780                
 Glu Glu Val Arg Lys Leu Thr Gln Arg Leu Glu Glu Met Thr Gln Arg
 785                 790                 795                 800
 Met Glu Ala Leu Glu Asn Arg Leu Arg Tyr Arg
                 805                 810    



      <210> 395
      <211> 140
      <212> PRT
      <213> Homo sapiens


      <400> 395
 Met Pro Gly Tyr Gly Ser His Phe Lys Pro Leu Pro Gln Gly His Ala
   1               5                  10                  15    
 Ile Glu Ser Ile Ser Lys Ser Met Phe Leu Ala Leu Lys Cys Leu Arg
              20                  25                  30        
 Pro Leu Arg Ile Ser Leu Pro Gly Gly Arg Trp Gly Asn Ile Cys His
          35                  40                  45            
 Val Lys Glu Gln Val Leu Ser Val Pro Gly Leu Glu Lys Asp Leu Arg
      50                  55                  60                
 Leu Arg Ser Gly Gln Ser Gly Ile Tyr Phe Ala Ser Pro Lys Tyr Pro
  65                  70                  75                  80
 Ala Gln Ser Gly Lys Lys Lys Lys Leu Leu Leu Pro Ser Ser Ser Trp
                  85                  90                  95    
 Gln Leu Asp Ile Lys Asn Lys Asn Ile Arg Ser Trp Thr Pro Val Leu
             100                 105                 110        
 Ser Ser Cys Pro Ser Leu Thr Cys Trp Leu Lys Leu Pro Pro Trp Arg
         115                 120                 125            
 Pro Tyr Leu Ser Leu Trp Thr Val Thr Val Asp Thr
     130                 135                 140



      <210> 396
      <211> 168
      <212> PRT
      <213> Homo sapiens


      <400> 396
 Met Asn Glu Val Lys Glu Ser Leu Arg Ser Ile Glu Gln Lys Tyr Lys
   1               5                  10                  15    
 Leu Phe Gln Gln Gln Gln Leu Thr Phe Thr Ala Ala Leu Glu His Cys
              20                  25                  30        
 Arg Glu Asn Ala His Asp Lys Ile Arg Pro Ile Ser Ser Ile Gly Gln
          35                  40                  45            
 Val Gln Ser Tyr Met Glu His Tyr Cys Asn Ser Ser Thr Asp Arg Arg
      50                  55                  60                
 Val Leu Leu Met Phe Leu Asp Ile Cys Ser Glu Leu Asn Lys Leu Cys
  65                  70                  75                  80
 Gln His Phe Glu Ala Val His Ser Gly Thr Pro Val Thr Asn Asn Leu
                  85                  90                  95    
 Leu Glu Lys Cys Lys Thr Leu Val Ser Gln Ser Asn Asp Leu Ser Ser
             100                 105                 110        
 Leu Arg Ala Lys Tyr Pro His Asp Val Val Asn His Leu Ser Cys Asp
         115                 120                 125            
 Glu Ala Arg Asn His Tyr Gly Gly Val Val Ser Leu Ile Pro Leu Ile
     130                 135                 140                
 Leu Asp Leu Met Lys Glu Trp Ile Ala His Ser Glu Lys Leu Pro Arg
 145                 150                 155                 160
 Lys Val Leu Gln His Gly Thr Thr
                 165            



      <210> 397
      <211> 875
      <212> PRT
      <213> Homo sapiens


      <400> 397
 Met Gly Asp Ser Asp Asp Glu Tyr Asp Arg Arg Arg Arg Asp Lys Phe
   1               5                  10                  15    
 Arg Arg Glu Arg Ser Asp Tyr Asp Arg Ser Arg Glu Arg Asp Glu Arg
              20                  25                  30        
 Arg Arg Gly Asp Asp Trp Asn Asp Arg Glu Trp Asp Arg Gly Arg Glu
          35                  40                  45            
 Arg Arg Ser Arg Gly Glu Tyr Arg Asp Tyr Asp Arg Asn Arg Arg Glu
      50                  55                  60                
 Arg Phe Ser Pro Pro Arg His Glu Leu Ser Pro Pro Gln Lys Arg Met
  65                  70                  75                  80
 Arg Arg Asp Trp Asp Glu His Ser Ser Asp Pro Tyr His Ser Gly Tyr
                  85                  90                  95    
 Glu Met Pro Tyr Ala Gly Gly Gly Gly Gly Pro Thr Tyr Gly Pro Pro
             100                 105                 110        
 Gln Pro Trp Gly His Pro Asp Val His Ile Met Gln His His Val Leu
         115                 120                 125            
 Pro Ile Gln Ala Arg Leu Gly Ser Ile Ala Glu Ile Asp Leu Gly Val
     130                 135                 140                
 Pro Pro Pro Val Met Lys Thr Phe Lys Glu Phe Leu Leu Ser Leu Asp
 145                 150                 155                 160
 Asp Ser Val Asp Glu Thr Glu Ala Val Lys Arg Tyr Asn Asp Tyr Lys
                 165                 170                 175    
 Leu Asp Phe Arg Arg Gln Gln Met Gln Asp Phe Phe Leu Ala His Lys
             180                 185                 190        
 Asp Glu Glu Trp Phe Arg Ser Lys Tyr His Pro Asp Glu Val Gly Lys
         195                 200                 205            
 Arg Arg Gln Glu Ala Arg Gly Ala Leu Gln Asn Arg Leu Arg Val Phe
     210                 215                 220                
 Leu Ser Leu Met Glu Thr Gly Trp Phe Asp Asn Leu Leu Leu Asp Ile
 225                 230                 235                 240
 Asp Lys Ala Asp Ala Ile Val Lys Met Leu Asp Ala Ala Val Ile Lys
                 245                 250                 255    
 Met Glu Gly Gly Thr Glu Asn Asp Leu Arg Ile Leu Glu Gln Glu Glu
             260                 265                 270        
 Glu Glu Glu Gln Ala Gly Lys Pro Gly Glu Pro Ser Lys Lys Glu Glu
         275                 280                 285            
 Gly Arg Ala Gly Ala Gly Leu Gly Asp Gly Glu Arg Lys Thr Asn Asp
     290                 295                 300                
 Lys Asp Glu Lys Lys Glu Asp Gly Lys Gln Ala Glu Asn Asp Ser Ser
 305                 310                 315                 320
 Asn Asp Asp Lys Thr Lys Lys Ser Glu Gly Asp Gly Asp Lys Glu Glu
                 325                 330                 335    
 Lys Lys Glu Asp Ser Glu Lys Glu Ala Lys Lys Ser Ser Lys Lys Arg
             340                 345                 350        
 Asn Arg Lys His Ser Gly Asp Asp Ser Phe Asp Glu Gly Ser Val Ser
         355                 360                 365            
 Glu Ser Glu Ser Glu Ser Glu Ser Gly Gln Ala Glu Glu Glu Lys Glu
     370                 375                 380                
 Glu Ala Glu Ala Leu Lys Glu Lys Glu Lys Pro Lys Glu Glu Glu Trp
 385                 390                 395                 400
 Glu Lys Pro Lys Asp Ala Ala Gly Leu Glu Cys Lys Pro Arg Pro Leu
                 405                 410                 415    
 His Lys Thr Cys Ser Leu Phe Met Arg Asn Ile Ala Pro Asn Ile Ser
             420                 425                 430        
 Arg Ala Glu Ile Ile Ser Leu Cys Lys Arg Tyr Pro Gly Phe Met Arg
         435                 440                 445            
 Val Ala Leu Ser Glu Pro Gln Pro Glu Arg Arg Phe Phe Arg Arg Gly
     450                 455                 460                
 Trp Val Thr Phe Asp Arg Ser Val Asn Ile Lys Glu Ile Cys Trp Asn
 465                 470                 475                 480
 Leu Gln Asn Ile Arg Leu Arg Glu Cys Glu Leu Ser Pro Gly Val Asn
                 485                 490                 495    
 Arg Asp Leu Thr Arg Arg Val Arg Asn Ile Asn Gly Ile Thr Gln His
             500                 505                 510        
 Lys Gln Ile Val Arg Asn Asp Ile Lys Leu Ala Ala Lys Leu Ile His
         515                 520                 525            
 Thr Leu Asp Asp Arg Thr Gln Leu Trp Ala Ser Glu Pro Gly Thr Pro
     530                 535                 540                
 Pro Leu Pro Thr Ser Leu Pro Ser Gln Asn Pro Ile Leu Lys Asn Ile
 545                 550                 555                 560
 Thr Asp Tyr Leu Ile Glu Glu Val Ser Ala Glu Glu Glu Glu Leu Leu
                 565                 570                 575    
 Gly Ser Ser Gly Gly Ala Pro Pro Glu Glu Pro Pro Lys Glu Gly Asn
             580                 585                 590        
 Pro Ala Glu Ile Asn Val Glu Arg Asp Glu Lys Leu Ile Lys Val Leu
         595                 600                 605            
 Asp Lys Leu Leu Leu Tyr Leu Arg Ile Val His Ser Leu Asp Tyr Tyr
     610                 615                 620                
 Asn Thr Cys Glu Tyr Pro Asn Glu Asp Glu Met Pro Asn Arg Cys Gly
 625                 630                 635                 640
 Ile Ile His Val Arg Gly Pro Met Pro Pro Asn Arg Ile Ser His Gly
                 645                 650                 655    
 Glu Val Leu Glu Trp Gln Lys Thr Phe Glu Glu Lys Leu Thr Pro Leu
             660                 665                 670        
 Leu Ser Val Arg Glu Ser Leu Ser Glu Glu Glu Ala Gln Lys Met Gly
         675                 680                 685            
 Arg Lys Asp Pro Glu Gln Glu Val Glu Lys Phe Val Thr Ser Asn Thr
     690                 695                 700                
 Gln Glu Leu Gly Lys Asp Lys Trp Leu Cys Pro Leu Ser Gly Lys Lys
 705                 710                 715                 720
 Phe Lys Gly Pro Glu Phe Val Arg Lys His Ile Phe Asn Lys His Ala
                 725                 730                 735    
 Glu Lys Ile Glu Glu Val Lys Lys Glu Val Ala Phe Phe Asn Asn Phe
             740                 745                 750        
 Leu Thr Asp Ala Lys Arg Pro Ala Leu Pro Glu Ile Lys Pro Ala Gln
         755                 760                 765            
 Pro Pro Gly Pro Ala Gln Ile Leu Pro Pro Gly Leu Thr Pro Gly Leu
     770                 775                 780                
 Pro Tyr Pro His Gln Thr Pro Gln Gly Leu Met Pro Tyr Gly Gln Pro
 785                 790                 795                 800
 Arg Pro Pro Ile Leu Gly Tyr Gly Ala Gly Ala Val Arg Pro Ala Val
                 805                 810                 815    
 Pro Thr Gly Gly Pro Pro Tyr Pro His Ala Pro Tyr Gly Ala Gly Arg
             820                 825                 830        
 Gly Asn Tyr Asp Ala Phe Arg Gly Gln Gly Gly Tyr Pro Gly Lys Pro
         835                 840                 845            
 Arg Asn Arg Met Val Arg Gly Asp Pro Arg Ala Ile Val Glu Tyr Arg
     850                 855                 860                
 Asp Leu Asp Ala Pro Asp Asp Val Asp Phe Phe
 865                 870                 875



      <210> 398
      <211> 54
      <212> PRT
      <213> Homo sapiens


      <400> 398
 Met Ser Asp Gln Ala Ile Met Glu Leu Asn Leu Pro Thr Gly Ile Pro
   1               5                  10                  15    
 Ile Val Tyr Glu Leu Asn Lys Glu Leu Lys Pro Thr Lys Pro Met Gln
              20                  25                  30        
 Phe Leu Gly Asp Glu Glu Thr Val Arg Lys Ala Met Glu Ala Val Ala
          35                  40                  45            
 Ala Gln Gly Lys Ala Lys
      50                



      <210> 399
      <211> 403
      <212> PRT
      <213> Homo sapiens


      <400> 399
 Met Thr Arg Ala Glu Trp Gln Val Ala Glu Ala Thr Ala Leu Val His
   1               5                  10                  15    
 Thr Leu Asp Gly Trp Ser Val Val Gln Thr Met Val Val Ser Thr Lys
              20                  25                  30        
 Thr Pro Asp Arg Lys Leu Ile Phe Gly Lys Gly Asn Phe Glu His Leu
          35                  40                  45            
 Thr Glu Lys Ile Arg Gly Ser Pro Asp Ile Thr Cys Val Phe Leu Asn
      50                  55                  60                
 Val Glu Arg Met Ala Ala Pro Thr Lys Lys Glu Leu Glu Ala Ala Trp
  65                  70                  75                  80
 Gly Val Glu Val Phe Asp Arg Phe Thr Val Val Leu His Ile Phe Arg
                  85                  90                  95    
 Cys Asn Ala Arg Thr Lys Glu Ala Arg Leu Gln Val Ala Leu Ala Glu
             100                 105                 110        
 Met Pro Leu His Arg Ser Asn Leu Lys Arg Asp Val Ala His Leu Tyr
         115                 120                 125            
 Arg Gly Val Gly Ser Arg Tyr Ile Met Gly Ser Gly Glu Ser Phe Met
     130                 135                 140                
 Gln Leu Gln Gln Arg Leu Leu Arg Glu Lys Glu Ala Lys Ile Arg Lys
 145                 150                 155                 160
 Ala Leu Asp Arg Leu Arg Lys Lys Arg His Leu Leu Arg Arg Gln Arg
                 165                 170                 175    
 Thr Arg Arg Glu Phe Pro Val Ile Ser Val Val Gly Tyr Thr Asn Cys
             180                 185                 190        
 Gly Lys Thr Thr Leu Ile Lys Ala Leu Thr Gly Asp Ala Ala Ile Gln
         195                 200                 205            
 Pro Arg Asp Gln Leu Phe Ala Thr Leu Asp Val Thr Ala His Ala Gly
     210                 215                 220                
 Thr Leu Pro Ser Arg Met Thr Val Leu Tyr Val Asp Thr Ile Gly Phe
 225                 230                 235                 240
 Leu Ser Gln Leu Pro His Gly Leu Ile Glu Ser Phe Ser Ala Thr Leu
                 245                 250                 255    
 Glu Asp Val Ala His Ser Asp Leu Ile Leu His Val Arg Asp Val Ser
             260                 265                 270        
 His Pro Glu Ala Glu Leu Gln Lys Cys Ser Val Leu Ser Thr Leu Arg
         275                 280                 285            
 Gly Leu Gln Leu Pro Ala Pro Leu Leu Asp Ser Met Val Glu Val His
     290                 295                 300                
 Asn Lys Val Asp Leu Val Pro Gly Tyr Ser Pro Thr Glu Pro Asn Val
 305                 310                 315                 320
 Val Pro Val Ser Ala Leu Arg Gly His Gly Leu Gln Glu Leu Lys Ala
                 325                 330                 335    
 Glu Leu Asp Ala Ala Val Leu Lys Ala Thr Gly Arg Gln Ile Leu Thr
             340                 345                 350        
 Leu Arg Val Arg Leu Ala Gly Ala Gln Leu Ser Trp Leu Tyr Lys Glu
         355                 360                 365            
 Ala Thr Val Gln Glu Val Asp Val Ile Pro Glu Asp Gly Ala Ala Asp
     370                 375                 380                
 Val Arg Val Ile Ile Ser Asn Ser Ala Tyr Gly Lys Phe Arg Lys Leu
 385                 390                 395                 400
 Phe Pro Gly
            



      <210> 400
      <211> 58
      <212> PRT
      <213> Homo sapiens


      <400> 400
 Met Met Leu Asp Asn Tyr Val Arg Asp Phe Lys Ala Leu Ile Asp Trp
   1               5                  10                  15    
 Ile Gln Leu Gln Glu Lys Leu Glu Lys Thr Asp Ala Gln Ser Arg Pro
              20                  25                  30        
 Thr Ser Leu Ala Trp Glu Val Lys Lys Met Ser Pro Gly Arg His Val
          35                  40                  45            
 Ile Pro Ser Pro Ser Thr Asp Arg Lys Met
      50                  55            



      <210> 401
      <211> 122
      <212> PRT
      <213> Homo sapiens


      <400> 401
 Met Lys Met Arg Lys Asn Gln His Lys Lys Ala Glu Asn Phe Lys Asn
   1               5                  10                  15    
 Gln Asn Ala Ser Ser Pro Leu Lys Asp Tyr Asn Cys Ser Pro Ala Lys
              20                  25                  30        
 Glu Gln Asn Trp Thr Glu Asn Glu Phe Asp Lys Leu Thr Glu Val Gly
          35                  40                  45            
 Phe Arg Arg Thr Asp Val Ser Gly Met Ala Ser Ser Leu Pro Ser Leu
      50                  55                  60                
 Glu Glu Trp Gln Gly Cys Ser Glu Pro Met Asp Asp Ser Tyr Leu Thr
  65                  70                  75                  80
 Leu Arg Lys Val Thr His Gly Gly Ser Ala Pro Pro Pro Ser Thr Leu
                  85                  90                  95    
 Gln Ser Gly Pro Leu Leu Asn Lys Gly Tyr Cys Arg Ser Leu Thr Ala
             100                 105                 110        
 Leu Arg Gln Ala Leu Glu Thr His Ser Leu
         115                 120        



      <210> 402
      <211> 310
      <212> PRT
      <213> Homo sapiens


      <400> 402
 Met Ser Gln Gln Leu Lys Lys Arg Ala Lys Thr Arg His Gln Lys Gly
   1               5                  10                  15    
 Leu Gly Gly Arg Ala Pro Ser Gly Ala Lys Pro Arg Gln Gly Lys Ser
              20                  25                  30        
 Ser Gln Asp Leu Gln Ala Glu Ile Glu Pro Val Ser Ala Val Trp Ala
          35                  40                  45            
 Leu Cys Asp Gly Tyr Val Cys Tyr Glu Pro Gly Pro Gln Ala Leu Gly
      50                  55                  60                
 Gly Asp Asp Phe Ser Asp Cys Tyr Ile Glu Cys Val Ile Arg Gly Glu
  65                  70                  75                  80
 Phe Ser Gln Pro Ile Leu Glu Glu Asp Ser Leu Phe Glu Ser Leu Glu
                  85                  90                  95    
 Tyr Leu Lys Lys Gly Ser Glu Gln Gln Leu Ser Gln Lys Val Phe Glu
             100                 105                 110        
 Ala Ser Ser Leu Glu Cys Ser Leu Glu Tyr Met Lys Lys Gly Val Lys
         115                 120                 125            
 Lys Glu Leu Pro Gln Lys Ile Val Gly Glu Asn Ser Leu Glu Tyr Ser
     130                 135                 140                
 Glu Tyr Met Thr Gly Lys Lys Leu Pro Pro Gly Gly Ile Pro Gly Ile
 145                 150                 155                 160
 Asp Leu Ser Asp Pro Lys Gln Leu Ala Glu Phe Ala Arg Lys Lys Pro
                 165                 170                 175    
 Pro Ile Asn Lys Glu Tyr Asp Ser Leu Ser Ala Ile Ala Cys Pro Gln
             180                 185                 190        
 Ser Gly Cys Thr Arg Lys Leu Arg Asn Arg Ala Ala Leu Arg Lys His
         195                 200                 205            
 Leu Leu Ile His Gly Pro Arg Asp His Val Cys Ala Glu Cys Gly Lys
     210                 215                 220                
 Ala Phe Val Glu Ser Ser Lys Leu Lys Arg His Phe Leu Val His Thr
 225                 230                 235                 240
 Gly Glu Lys Pro Phe Arg Cys Thr Phe Glu Gly Cys Gly Lys Arg Phe
                 245                 250                 255    
 Ser Leu Asp Phe Asn Leu Arg Thr His Val Arg Ile His Thr Gly Glu
             260                 265                 270        
 Lys Arg Phe Val Cys Pro Phe Gln Gly Cys Asn Arg Arg Phe Ile Gln
         275                 280                 285            
 Ser Asn Asn Leu Lys Ala His Ile Leu Thr His Ala Asn Thr Asn Lys
     290                 295                 300                
 Asn Glu Gln Glu Gly Lys
 305                 310



      <210> 403
      <211> 769
      <212> PRT
      <213> Homo sapiens


      <400> 403
 Met Ser Ser Arg Thr Val Leu Ala Pro Gly Asn Asp Arg Asn Ser Asp
   1               5                  10                  15    
 Thr His Gly Thr Leu Gly Ser Gly Arg Ser Ser Asp Lys Gly Pro Ser
              20                  25                  30        
 Trp Ser Ser Arg Ser Leu Gly Ala Arg Cys Arg Asn Ser Ile Ala Ser
          35                  40                  45            
 Cys Pro Glu Glu Gln Pro His Val Gly Asn Tyr Arg Leu Leu Arg Thr
      50                  55                  60                
 Ile Gly Lys Gly Asn Phe Ala Lys Val Lys Leu Ala Arg His Ile Leu
  65                  70                  75                  80
 Thr Gly Arg Glu Val Ala Ile Lys Ile Ile Asp Lys Thr Gln Leu Asn
                  85                  90                  95    
 Pro Ser Ser Leu Gln Lys Leu Phe Arg Glu Val Arg Ile Met Lys Gly
             100                 105                 110        
 Leu Asn His Pro Asn Ile Val Lys Leu Phe Glu Val Ile Glu Thr Glu
         115                 120                 125            
 Lys Thr Leu Tyr Leu Val Met Glu Tyr Ala Ser Ala Gly Glu Val Phe
     130                 135                 140                
 Asp Tyr Leu Val Ser His Gly Arg Met Lys Glu Lys Glu Ala Arg Ala
 145                 150                 155                 160
 Lys Phe Arg Gln Ile Val Ser Ala Val His Tyr Cys His Gln Lys Asn
                 165                 170                 175    
 Ile Val His Arg Asp Leu Lys Ala Glu Asn Leu Leu Leu Asp Ala Glu
             180                 185                 190        
 Ala Asn Ile Lys Ile Ala Asp Phe Gly Phe Ser Asn Glu Phe Thr Leu
         195                 200                 205            
 Gly Ser Lys Leu Asp Thr Phe Cys Gly Ser Pro Pro Tyr Ala Ala Pro
     210                 215                 220                
 Glu Leu Phe Gln Gly Lys Lys Tyr Asp Gly Pro Glu Val Asp Ile Trp
 225                 230                 235                 240
 Ser Leu Gly Val Ile Leu Tyr Thr Leu Val Ser Gly Ser Leu Pro Phe
                 245                 250                 255    
 Asp Gly His Asn Leu Lys Glu Leu Arg Glu Arg Val Leu Arg Gly Lys
             260                 265                 270        
 Tyr Arg Val Pro Phe Tyr Met Ser Thr Asp Cys Glu Ser Ile Leu Arg
         275                 280                 285            
 Arg Phe Leu Val Leu Asn Pro Ala Lys Arg Cys Thr Leu Glu Gln Ile
     290                 295                 300                
 Met Lys Asp Lys Trp Ile Asn Ile Gly Tyr Glu Gly Glu Glu Leu Lys
 305                 310                 315                 320
 Pro Tyr Thr Glu Pro Glu Glu Asp Phe Gly Asp Thr Lys Arg Ile Glu
                 325                 330                 335    
 Val Met Val Gly Met Gly Tyr Thr Arg Glu Glu Ile Lys Glu Ser Leu
             340                 345                 350        
 Thr Ser Gln Lys Tyr Asn Glu Val Thr Ala Thr Tyr Leu Leu Leu Gly
         355                 360                 365            
 Arg Lys Thr Glu Glu Gly Gly Asp Arg Gly Ala Pro Gly Leu Ala Leu
     370                 375                 380                
 Ala Arg Val Arg Ala Pro Ser Asp Thr Thr Asn Gly Thr Ser Ser Ser
 385                 390                 395                 400
 Lys Gly Thr Ser His Ser Lys Gly Gln Arg Ser Ser Ser Ser Thr Tyr
                 405                 410                 415    
 His Arg Gln Arg Arg His Ser Asp Phe Ser Thr Asn Leu Leu Ser Met
             420                 425                 430        
 Ser Met Asn Leu Ala Ile Leu Asp Ile Ser Gly Gly Pro Ser Pro Ala
         435                 440                 445            
 Pro Leu His Pro Lys Arg Ser Pro Thr Ser Thr Gly Glu Ala Glu Leu
     450                 455                 460                
 Lys Glu Glu Arg Leu Pro Gly Arg Lys Ala Ser Cys Ser Thr Ala Gly
 465                 470                 475                 480
 Ser Gly Ser Arg Gly Leu Pro Pro Ser Ser Pro Met Val Ser Ser Ala
                 485                 490                 495    
 His Asn Pro Asn Lys Ala Glu Ile Pro Glu Arg Arg Lys Asp Ser Thr
             500                 505                 510        
 Ser Thr Pro Asn Asn Leu Pro Pro Ser Met Met Thr Arg Arg Asn Thr
         515                 520                 525            
 Tyr Val Cys Thr Glu Arg Pro Gly Ala Glu Arg Pro Ser Leu Leu Pro
     530                 535                 540                
 Asn Gly Lys Glu Asn Ser Ser Gly Thr Pro Arg Val Pro Pro Ala Ser
 545                 550                 555                 560
 Pro Ser Ser His Ser Leu Ala Pro Pro Ser Gly Glu Arg Ser Arg Leu
                 565                 570                 575    
 Ala Arg Gly Ser Thr Ile Arg Ser Thr Phe His Gly Gly Gln Val Arg
             580                 585                 590        
 Asp Arg Arg Ala Gly Gly Gly Gly Gly Gly Gly Val Gln Asn Gly Pro
         595                 600                 605            
 Pro Ala Ser Pro Thr Leu Ala His Glu Ala Ala Pro Leu Pro Ala Gly
     610                 615                 620                
 Arg Pro Arg Pro Thr Thr Asn Leu Phe Thr Lys Leu Thr Ser Lys Leu
 625                 630                 635                 640
 Thr Arg Arg Val Ala Asp Glu Pro Glu Arg Ile Gly Gly Pro Glu Val
                 645                 650                 655    
 Thr Ser Cys His Leu Pro Trp Asp Gln Thr Glu Thr Ala Pro Arg Leu
             660                 665                 670        
 Leu Arg Phe Pro Trp Ser Val Lys Leu Thr Ser Ser Arg Pro Pro Glu
         675                 680                 685            
 Ala Leu Met Ala Ala Leu Arg Gln Ala Thr Ala Ala Ala Arg Cys Arg
     690                 695                 700                
 Cys Arg Gln Pro Gln Pro Phe Leu Leu Ala Cys Leu His Gly Gly Ala
 705                 710                 715                 720
 Gly Gly Pro Glu Pro Leu Ser His Phe Glu Val Glu Val Cys Gln Leu
                 725                 730                 735    
 Pro Arg Pro Gly Leu Arg Gly Val Leu Phe Arg Arg Val Ala Gly Thr
             740                 745                 750        
 Ala Leu Ala Phe Arg Thr Leu Val Thr Arg Ile Ser Asn Asp Leu Glu
         755                 760                 765            
 Leu
    



      <210> 404
      <211> 158
      <212> PRT
      <213> Homo sapiens


      <400> 404
 Met Ala Asp Ile Gln Thr Glu Arg Ala Tyr Gln Lys Gln Pro Thr Ile
   1               5                  10                  15    
 Phe Gln Asn Lys Lys Arg Val Leu Leu Gly Glu Thr Gly Lys Glu Lys
              20                  25                  30        
 Leu Pro Arg Tyr Tyr Lys Asn Ile Gly Leu Gly Phe Lys Thr Pro Lys
          35                  40                  45            
 Glu Ala Ile Glu Gly Thr Tyr Ile Asp Lys Lys Cys Pro Phe Thr Gly
      50                  55                  60                
 Asn Val Ser Ile Arg Gly Arg Ile Leu Ser Gly Val Val Thr Lys Met
  65                  70                  75                  80
 Lys Met Gln Arg Thr Ile Val Ile Arg Arg Asp Tyr Leu His Tyr Ile
                  85                  90                  95    
 Arg Lys Tyr Asn Arg Phe Glu Lys Arg His Lys Asn Met Ser Val His
             100                 105                 110        
 Leu Ser Pro Cys Phe Arg Asp Val Gln Ile Gly Asp Ile Val Thr Val
         115                 120                 125            
 Gly Glu Cys Arg Pro Leu Ser Lys Thr Val Arg Phe Asn Val Leu Lys
     130                 135                 140                
 Val Thr Lys Ala Ala Gly Thr Lys Lys Gln Phe Gln Lys Phe
 145                 150                 155            



      <210> 405
      <211> 62
      <212> PRT
      <213> Homo sapiens


      <400> 405
 Met Arg Leu Ser Phe Trp Ala Phe Cys Val Val Thr Val Pro Asp His
   1               5                  10                  15    
 Gly Thr Phe Ser Leu Pro Gln Asp Arg Thr Phe Ser Leu Pro Gln Pro
              20                  25                  30        
 Pro Ser Cys Pro Gly Val Glu Ser Ser Lys Trp Lys Ile Pro Ala Ile
          35                  40                  45            
 Ser Ile Gly Asp Ala Pro Ile Ser Ser Cys Gly Thr Thr Val
      50                  55                  60        



      <210> 406
      <211> 99
      <212> PRT
      <213> Homo sapiens


      <400> 406
 Met Ala Glu Gly Asn Thr Leu Ile Ser Val Asp Tyr Glu Ile Phe Gly
   1               5                  10                  15    
 Lys Val Gln Gly Val Phe Phe Arg Lys His Thr Gln Ala Glu Gly Lys
              20                  25                  30        
 Lys Leu Gly Leu Val Gly Trp Val Gln Asn Thr Asp Arg Gly Thr Val
          35                  40                  45            
 Gln Gly Gln Leu Gln Gly Pro Ile Ser Lys Val Arg His Met Gln Glu
      50                  55                  60                
 Trp Leu Glu Thr Arg Gly Ser Pro Lys Ser His Ile Asp Lys Ala Asn
  65                  70                  75                  80
 Phe Asn Asn Glu Lys Val Ile Leu Lys Leu Asp Tyr Ser Asp Phe Gln
                  85                  90                  95    
 Ile Val Lys
            



      <210> 407
      <211> 956
      <212> PRT
      <213> Homo sapiens


      <400> 407
 Met Ala Ala Ala Val Gly Val Arg Gly Arg Tyr Glu Leu Pro Pro Cys
   1               5                  10                  15    
 Ser Gly Pro Gly Trp Leu Leu Ser Leu Ser Ala Leu Leu Ser Val Ala
              20                  25                  30        
 Ala Arg Gly Ala Phe Ala Thr Thr His Trp Val Val Thr Glu Asp Gly
          35                  40                  45            
 Lys Ile Gln Gln Gln Val Asp Ser Pro Met Asn Leu Lys His Pro His
      50                  55                  60                
 Asp Leu Val Ile Leu Met Arg Gln Glu Ala Thr Val Asn Tyr Leu Lys
  65                  70                  75                  80
 Glu Leu Glu Lys Gln Leu Val Ala Gln Lys Ile His Ile Glu Glu Asn
                  85                  90                  95    
 Glu Asp Arg Asp Thr Gly Leu Glu Gln Arg His Asn Lys Glu Asp Pro
             100                 105                 110        
 Asp Cys Ile Lys Ala Lys Val Pro Leu Gly Asp Leu Asp Leu Tyr Asp
         115                 120                 125            
 Gly Thr Tyr Ile Thr Leu Glu Ser Lys Asp Ile Ser Pro Glu Asp Tyr
     130                 135                 140                
 Ile Asp Thr Glu Ser Pro Val Pro Pro Asp Pro Glu Gln Pro Asp Cys
 145                 150                 155                 160
 Thr Lys Ile Leu Glu Leu Pro Tyr Ser Ile His Ala Phe Gln His Leu
                 165                 170                 175    
 Arg Gly Val Gln Glu Arg Val Asn Leu Ser Ala Pro Leu Leu Pro Lys
             180                 185                 190        
 Glu Asp Pro Ile Phe Thr Tyr Leu Ser Lys Arg Leu Gly Arg Ser Ile
         195                 200                 205            
 Asp Asp Ile Gly His Leu Ile His Glu Gly Leu Gln Lys Asn Thr Ser
     210                 215                 220                
 Ser Trp Val Leu Tyr Asn Met Ala Ser Phe Tyr Trp Arg Ile Lys Asn
 225                 230                 235                 240
 Glu Pro Tyr Gln Val Val Glu Cys Ala Met Arg Ala Leu His Phe Ser
                 245                 250                 255    
 Ser Arg His Asn Lys Asp Ile Ala Leu Val Asn Leu Ala Asn Val Leu
             260                 265                 270        
 His Arg Ala His Phe Ser Ala Asp Ala Ala Val Val Val His Ala Ala
         275                 280                 285            
 Leu Asp Asp Ser Asp Phe Phe Thr Ser Tyr Tyr Thr Leu Gly Asn Ile
     290                 295                 300                
 Tyr Ala Met Leu Gly Glu Tyr Asn His Ser Val Leu Cys Tyr Asp His
 305                 310                 315                 320
 Ala Leu Gln Ala Arg Pro Gly Phe Gly Gln Ala Ile Lys Arg Lys His
                 325                 330                 335    
 Ala Val Leu Cys Gln Gln Lys Leu Glu Gln Lys Leu Glu Ala Gln His
             340                 345                 350        
 Arg Ser Leu Gln Arg Thr Leu Asn Glu Leu Lys Glu Tyr Gln Lys Gln
         355                 360                 365            
 His Asp His Tyr Leu Arg Gln Gln Glu Ile Leu Glu Lys His Lys Leu
     370                 375                 380                
 Ile Gln Glu Glu Gln Ile Leu Arg Asn Ile Ile His Glu Thr Gln Met
 385                 390                 395                 400
 Ala Lys Glu Ala Gln Leu Gly Asn His Gln Ile Cys Arg Leu Val Asn
                 405                 410                 415    
 Gln Gln His Ser Leu His Cys Gln Trp Asp Gln Pro Val Arg Tyr His
             420                 425                 430        
 Arg Gly Asp Ile Phe Glu Asn Val Asp Tyr Val Gln Phe Gly Glu Asp
         435                 440                 445            
 Ser Ser Thr Ser Ser Met Met Ser Val Asn Phe Asp Val Gln Ser Asn
     450                 455                 460                
 Gln Ser Asp Ile Asn Asp Ser Val Lys Ser Ser Pro Val Ala His Ser
 465                 470                 475                 480
 Ile Leu Trp Ile Trp Gly Arg Asp Ser Asp Ala Tyr Arg Asp Lys Gln
                 485                 490                 495    
 His Ile Leu Trp Pro Lys Arg Ala Asp Cys Thr Glu Ser Tyr Pro Arg
             500                 505                 510        
 Val Pro Val Gly Gly Glu Leu Pro Thr Tyr Phe Leu Pro Pro Glu Asn
         515                 520                 525            
 Lys Gly Leu Arg Ile His Glu Leu Ser Ser Asp Asp Tyr Ser Thr Glu
     530                 535                 540                
 Glu Glu Ala Gln Thr Pro Asp Cys Ser Ile Thr Asp Phe Arg Lys Ser
 545                 550                 555                 560
 His Thr Leu Ser Tyr Leu Val Lys Glu Leu Glu Val Arg Met Asp Leu
                 565                 570                 575    
 Lys Ala Lys Met Pro Asp Asp His Ala Arg Lys Ile Leu Leu Ser Arg
             580                 585                 590        
 Ile Asn Asn Tyr Thr Ile Pro Glu Glu Glu Ile Gly Ser Phe Leu Phe
         595                 600                 605            
 His Ala Ile Asn Lys Pro Asn Ala Pro Ile Trp Leu Ile Leu Asn Glu
     610                 615                 620                
 Ala Gly Leu Tyr Trp Arg Ala Val Gly Asn Ser Thr Phe Ala Ile Ala
 625                 630                 635                 640
 Cys Leu Gln Arg Ala Leu Asn Leu Ala Pro Leu Gln Tyr Gln Asp Val
                 645                 650                 655    
 Pro Leu Val Asn Leu Ala Asn Leu Leu Ile His Tyr Gly Leu His Leu
             660                 665                 670        
 Asp Ala Thr Lys Leu Leu Leu Gln Ala Leu Ala Ile Asn Ser Ser Glu
         675                 680                 685            
 Pro Leu Thr Phe Leu Ser Leu Gly Asn Ala Tyr Leu Ala Leu Lys Asn
     690                 695                 700                
 Ile Ser Gly Ala Leu Glu Ala Phe Arg Gln Ala Leu Lys Leu Thr Thr
 705                 710                 715                 720
 Lys Cys Pro Glu Cys Glu Asn Ser Leu Lys Leu Ile Arg Cys Met Gln
                 725                 730                 735    
 Phe Tyr Pro Phe Leu Tyr Asn Ile Thr Ser Ser Val Cys Ser Gly Asn
             740                 745                 750        
 Cys His Glu Lys Thr Leu Asp Asn Ser His Asp Lys Gln Lys Tyr Phe
         755                 760                 765            
 Asp Asn Ser Gln Ser Leu Asp Ala Ala Glu Glu Glu Pro Ser Glu Arg
     770                 775                 780                
 Gly Thr Glu Glu Asp Pro Val Phe Ser Val Glu Asn Ser Gly Arg Asp
 785                 790                 795                 800
 Ser Asp Ala Leu Arg Leu Glu Ser Thr Val Val Glu Glu Ser Asn Gly
                 805                 810                 815    
 Ser Asp Glu Met Glu Asn Ser Asp Glu Thr Lys Met Ser Glu Glu Ile
             820                 825                 830        
 Leu Ala Leu Val Asp Glu Phe Gln Gln Ala Trp Pro Leu Glu Gly Phe
         835                 840                 845            
 Gly Gly Ala Leu Glu Met Lys Gly Arg Arg Leu Asp Leu Gln Gly Ile
     850                 855                 860                
 Arg Val Leu Lys Lys Gly Pro Gln Asp Gly Val Ala Arg Ser Ser Cys
 865                 870                 875                 880
 Tyr Gly Asp Cys Arg Ser Glu Asp Asp Glu Ala Thr Glu Trp Ile Thr
                 885                 890                 895    
 Phe Gln Val Lys Arg Val Lys Lys Pro Lys Gly Asp His Lys Lys Thr
             900                 905                 910        
 Pro Gly Lys Lys Val Glu Thr Gly Gln Ile Glu Asn Gly His Arg Tyr
         915                 920                 925            
 Gln Ala Asn Leu Glu Ile Thr Gly Pro Lys Val Ala Ser Pro Gly Pro
     930                 935                 940                
 Gln Gly Leu Leu Asp Trp Lys Thr Arg Lys Val Pro
 945                 950                 955    



      <210> 408
      <211> 85
      <212> PRT
      <213> Homo sapiens


      <400> 408
 Met Ser Phe Gly Asp Gln Met Asp Ser Phe Leu Ser Gly Met Tyr Leu
   1               5                  10                  15    
 Arg Val Lys Leu Phe Tyr His Ser Val Cys Phe Thr Phe Ser Ala Phe
              20                  25                  30        
 Gln Phe Leu Ile Lys Lys Ser Leu Pro Ala Pro Lys Asp Val Lys Leu
          35                  40                  45            
 Phe Ser Tyr Gly Leu Ala Gln Trp Leu Met Pro Val Ile Pro Ala Phe
      50                  55                  60                
 Trp Glu Ala Lys Val Gly Gly Leu Leu Glu Ala Arg Ser Ser Arg Pro
  65                  70                  75                  80
 Ala Trp Ala Thr Tyr
                  85



      <210> 409
      <211> 306
      <212> PRT
      <213> Homo sapiens


      <400> 409
 Met Glu Thr Pro Glu Val Pro Val Gly Ser Leu Ile Asp Phe Gly Pro
   1               5                  10                  15    
 Glu Ala Pro Thr Ser Ser Pro Leu Glu Ala Pro Pro Pro Val Leu Gln
              20                  25                  30        
 Asp Gly Asp Gly Ser Leu Gly Asp Gly Ala Ser Glu Ser Glu Thr Thr
          35                  40                  45            
 Glu Ser Ala Asp Ser Glu Asn Asp Met Gly Glu Ser Pro Ser His Pro
      50                  55                  60                
 Ser Trp Asp Gln Asp Arg Arg Ser Ser Ser Asn Glu Ser Phe Ser Ser
  65                  70                  75                  80
 Asn Gln Ser Thr Glu Ser Thr Gln Asp Glu Glu Thr Leu Ala Leu Arg
                  85                  90                  95    
 Asp Phe Met Arg Gly Tyr Val Glu Lys Ile Phe Ser Gly Gly Glu Asp
             100                 105                 110        
 Leu Asp Gln Glu Glu Lys Ala Lys Phe Gly Glu Tyr Cys Ser Ser Glu
         115                 120                 125            
 Asn Gly Lys Gly Arg Glu Trp Phe Ala Arg Tyr Val Ser Ala Gln Arg
     130                 135                 140                
 Cys Asn Ser Lys Cys Val Ser Glu Ala Thr Phe Tyr Arg Leu Val Gln
 145                 150                 155                 160
 Ser Phe Ala Val Val Leu Phe Glu Cys His Gln Met Asp Asp Phe Gly
                 165                 170                 175    
 Pro Ala Lys Asn Leu Met Thr Met Cys Phe Thr Tyr Tyr His Ile Gly
             180                 185                 190        
 Lys Pro Gln Leu Leu Pro Pro Glu Ser Arg Glu Lys Pro Ala Gly Ser
         195                 200                 205            
 Ile Asp Ser Tyr Leu Lys Ser Ala Asn Ser Trp Leu Ala Glu Lys Lys
     210                 215                 220                
 Asp Ile Ala Glu Arg Leu Leu Lys Asn Thr Ser Ala Arg Thr Glu Asn
 225                 230                 235                 240
 Val Lys Gly Phe Phe Gly Gly Leu Glu Thr Lys Leu Lys Gly Pro Leu
                 245                 250                 255    
 Ala Arg Arg Asn Glu Glu Asp Glu Asn Lys Pro Gln Glu Lys Arg Pro
             260                 265                 270        
 Arg Ala Val Thr Ala Tyr Ser Pro Glu Asp Glu Lys Lys Gly Glu Lys
         275                 280                 285            
 Ile Tyr Leu Tyr Thr His Leu Lys Gln Gln Pro Ile Trp His Thr Leu
     290                 295                 300                
 Arg Phe
 305    



      <210> 410
      <211> 323
      <212> PRT
      <213> Homo sapiens


      <400> 410
 Met Gly Asn Leu Leu Lys Val Leu Thr Arg Glu Ile Glu Asn Tyr Pro
   1               5                  10                  15    
 His Phe Phe Leu Asp Phe Glu Asn Ala Gln Pro Thr Glu Gly Glu Arg
              20                  25                  30        
 Glu Ile Trp Asn Gln Ile Ser Ala Val Leu Gln Asp Ser Glu Ser Ile
          35                  40                  45            
 Leu Ala Asp Leu Gln Ala Tyr Lys Gly Ala Gly Leu Glu Ile Arg Asp
      50                  55                  60                
 Ala Ile Gln Asn Pro Asn Asp Ile Gln Leu Gln Glu Lys Ala Trp Asn
  65                  70                  75                  80
 Ala Val Cys Pro Leu Val Val Arg Leu Lys Arg Phe Tyr Glu Phe Ser
                  85                  90                  95    
 Ile Arg Leu Glu Lys Ala Leu Gln Ser Leu Leu Glu Ser Leu Thr Cys
             100                 105                 110        
 Pro Pro Tyr Thr Pro Thr Gln His Leu Glu Arg Glu Gln Ala Leu Ala
         115                 120                 125            
 Lys Glu Phe Ala Glu Ile Leu His Phe Thr Leu Arg Phe Asp Glu Leu
     130                 135                 140                
 Lys Met Arg Asn Pro Ala Ile Gln Asn Asp Phe Ser Tyr Tyr Arg Arg
 145                 150                 155                 160
 Thr Ile Ser Arg Asn Arg Ile Asn Asn Met His Leu Asp Ile Glu Asn
                 165                 170                 175    
 Glu Val Asn Asn Glu Met Ala Asn Arg Met Ser Leu Phe Tyr Ala Glu
             180                 185                 190        
 Ala Thr Pro Met Leu Lys Thr Leu Ser Asn Ala Thr Met His Phe Val
         195                 200                 205            
 Ser Glu Asn Lys Thr Leu Pro Ile Glu Asn Thr Thr Asp Cys Leu Ser
     210                 215                 220                
 Thr Met Thr Ser Val Cys Lys Val Met Leu Glu Thr Pro Glu Tyr Arg
 225                 230                 235                 240
 Ser Arg Phe Thr Ser Glu Glu Thr Leu Met Phe Cys Met Arg Val Met
                 245                 250                 255    
 Val Gly Val Ile Ile Leu Tyr Asp His Val His Pro Val Gly Ala Phe
             260                 265                 270        
 Cys Lys Thr Ser Lys Ile Asp Met Lys Gly Cys Ile Lys Val Leu Lys
         275                 280                 285            
 Glu Gln Ala Pro Asp Ser Val Glu Gly Leu Leu Asn Ala Leu Arg Phe
     290                 295                 300                
 Thr Thr Lys His Leu Asn Asp Glu Ser Thr Ser Lys Gln Ile Arg Ala
 305                 310                 315                 320
 Met Leu Gln
            



      <210> 411
      <211> 86
      <212> PRT
      <213> Homo sapiens


      <400> 411
 Met Val Leu Cys Pro Phe Ile Arg Arg Leu Leu Lys Asn Trp Ala Val
   1               5                  10                  15    
 Cys Lys Ala Asn Pro Ala Pro Cys Pro Ser Arg Phe Ser Glu Arg Gly
              20                  25                  30        
 Val Pro Trp Asp Gly Ala Ala Pro Leu Thr Ala Ala Pro Arg Phe Gln
          35                  40                  45            
 Ser Leu Asp Ala Thr Asn Gln His Gly Leu Cys Ser Gly His Arg Val
      50                  55                  60                
 Asn Phe Ser Leu Thr Pro Gly Ala Gly Pro Val Pro Ala Arg Ser Ser
  65                  70                  75                  80
 Tyr Ser Val Glu Val Cys
                  85    



      <210> 412
      <211> 187
      <212> PRT
      <213> Homo sapiens


      <400> 412
 Met Lys Cys Pro Asp Gln Lys Cys Leu Tyr Thr Cys Gln Ile Lys Asp
   1               5                  10                  15    
 Gly Gly Val Gln Pro Gln Phe Glu Ile Val Pro Glu Asp Asp Pro Gln
              20                  25                  30        
 Asn Ala Ile Val Ser Ser Ser Ala Asp Ala Cys His Ala Glu Leu Leu
          35                  40                  45            
 Arg Thr Ile Ser Thr Thr Met Gly Lys Leu Met Pro Asn Leu Leu Pro
      50                  55                  60                
 Ala Gly Ala Asp Phe Phe Gly Phe Ser His Pro Ala Ile His Asn Leu
  65                  70                  75                  80
 Ile Gln Ser Cys Pro Gly Ala Arg Lys Cys Ile Asn Tyr Gln Trp Val
                  85                  90                  95    
 Lys Phe Asp Val Cys Lys Pro Gly Asp Gly Gln Leu Pro Glu Gly Leu
             100                 105                 110        
 Pro Glu Asn Asp Ala Ala Met Ser Phe Glu Ala Phe Gln Arg Gln Ile
         115                 120                 125            
 Phe Asp Glu Asp Gln Asn Asp Pro Leu Leu Pro Gly Ser Leu Asp Leu
     130                 135                 140                
 Pro Glu Leu Gln Pro Ala Ala Phe Val Ser Ser Tyr Gln Pro Met Tyr
 145                 150                 155                 160
 Leu Thr His Glu Pro Leu Val Asp Thr His Leu Gln His Leu Lys Ser
                 165                 170                 175    
 Pro Ser Gln Gly Ser Pro Ile Gln Ser Ser Asp
             180                 185        



      <210> 413
      <211> 67
      <212> PRT
      <213> Homo sapiens


      <400> 413
 Met Ser Gly Pro Ala Ala Thr Thr Phe His Trp Lys Lys Cys Arg Leu
   1               5                  10                  15    
 Asp Leu Pro Gly His Val Ala Leu Gln Ala Cys Lys Arg Leu Pro Asp
              20                  25                  30        
 Glu His Asn His Val Gln Lys Lys Thr Phe Thr Lys Trp Ile Asn Ala
          35                  40                  45            
 Arg Phe Ser Lys Val Thr Glu Thr Phe Lys Asn Phe Asp Gly Ser Asp
      50                  55                  60                
 Ala Ala Phe
  65        



      <210> 414
      <211> 980
      <212> PRT
      <213> Homo sapiens


      <400> 414
 Met Glu Ile Val Thr Glu Glu Lys Gly Glu Leu Val Leu His Arg Tyr
   1               5                  10                  15    
 Tyr Leu Ser Lys Lys Ser Gln Pro Glu Lys Val Trp Leu Asp Gln Lys
              20                  25                  30        
 Glu Asp Asp Lys Lys Tyr Met Lys Arg Val His Ser Pro Thr Lys Pro
          35                  40                  45            
 Ala Ser Tyr Ser Val Lys Trp Thr Ile Glu Glu Lys Glu Leu Phe Glu
      50                  55                  60                
 Gln Gly Leu Pro Gly Ala Ile Tyr Arg Tyr Arg Gln Lys Arg Ser Gly
  65                  70                  75                  80
 Gln Tyr Gly Leu Leu Pro Ser Arg Thr Leu Ile Arg Cys Ser His Asp
                  85                  90                  95    
 Glu Ala Val Leu Ala Leu Val Pro Ala Gly Cys Arg Cys Gly Val Gln
             100                 105                 110        
 Ala Lys Phe Gly Arg Arg Trp Thr Lys Ile Ser Lys Leu Ile Gly Ser
         115                 120                 125            
 Arg Thr Val Leu Gln Val Lys Ser Tyr Ala Arg Gln Tyr Phe Lys Asn
     130                 135                 140                
 Lys Val Lys Cys Gly Leu Asp Lys Glu Thr Pro Asn Gln Lys Thr Gly
 145                 150                 155                 160
 His Asn Leu Gln Val Lys Asn Glu Asp Lys Gly Thr Lys Ala Trp Thr
                 165                 170                 175    
 Pro Ser Cys Leu Arg Gly Arg Ala Asp Pro Asn Leu Asn Ala Val Lys
             180                 185                 190        
 Ile Glu Lys Leu Ser Asp Asp Glu Glu Val Asp Ile Thr Asp Glu Val
         195                 200                 205            
 Asp Glu Leu Ser Ser Gln Thr Pro Gln Lys Asn Ser Ser Ser Asp Leu
     210                 215                 220                
 Leu Leu Asp Phe Pro Asn Ser Lys Met His Glu Thr Asn Gln Gly Glu
 225                 230                 235                 240
 Phe Ile Ala Ser Asp Ser Gln Glu Ala Leu Phe Ser Lys Ser Ser Arg
                 245                 250                 255    
 Gly Cys Leu Gln Asn Glu Lys Gln Asp Glu Thr Leu Ser Ser Ser Glu
             260                 265                 270        
 Ile Thr Leu Trp Thr Glu Lys Gln Ser Asn Gly Asp Lys Lys Ser Ile
         275                 280                 285            
 Glu Leu Asn Asp Gln Lys Phe Asn Glu Leu Ile Lys Asn Cys Asn Lys
     290                 295                 300                
 His Asp Gly Arg Gly Ile Ile Val Asp Ala Arg Gln Leu Pro Ser Pro
 305                 310                 315                 320
 Glu Pro Cys Glu Ile Gln Lys Asn Leu Asn Asp Asn Glu Met Leu Phe
                 325                 330                 335    
 His Ser Cys Gln Met Val Glu Glu Ser His Glu Glu Glu Glu Leu Lys
             340                 345                 350        
 Pro Pro Glu Gln Glu Ile Glu Ile Asp Arg Asn Ile Ile Gln Glu Glu
         355                 360                 365            
 Glu Lys Gln Ala Ile Pro Glu Phe Phe Glu Gly Arg Gln Ala Lys Thr
     370                 375                 380                
 Pro Glu Arg Tyr Leu Lys Ile Arg Asn Tyr Ile Leu Asp Gln Trp Glu
 385                 390                 395                 400
 Ile Cys Lys Pro Lys Tyr Leu Asn Lys Thr Ser Val Arg Pro Gly Leu
                 405                 410                 415    
 Lys Asn Cys Gly Asp Val Asn Cys Ile Gly Arg Ile His Thr Tyr Leu
             420                 425                 430        
 Glu Leu Ile Gly Ala Ile Asn Phe Gly Cys Glu Gln Ala Val Tyr Asn
         435                 440                 445            
 Arg Pro Gln Thr Val Asp Lys Val Arg Ile Arg Asp Arg Lys Asp Ala
     450                 455                 460                
 Val Glu Ala Tyr Gln Leu Ala Gln Arg Leu Gln Ser Met Arg Thr Arg
 465                 470                 475                 480
 Arg Arg Arg Val Arg Asp Pro Trp Gly Asn Trp Cys Asp Ala Lys Asp
                 485                 490                 495    
 Leu Glu Gly Gln Thr Phe Glu Glu Pro Phe Gln Val Lys Val Ala Ser
             500                 505                 510        
 Glu Ala Leu Leu Ile Met Asp Leu His Ala His Val Ser Met Ala Glu
         515                 520                 525            
 Val Ile Gly Leu Leu Gly Gly Arg Tyr Ser Glu Val Asp Lys Val Val
     530                 535                 540                
 Glu Val Cys Ala Ala Glu Pro Cys Asn Ser Leu Ser Thr Gly Leu Gln
 545                 550                 555                 560
 Cys Glu Met Asp Pro Val Ser Gln Thr Gln Ala Ser Glu Thr Leu Ala
                 565                 570                 575    
 Val Arg Gly Phe Ser Val Ile Gly Trp Tyr His Ser His Pro Ala Phe
             580                 585                 590        
 Asp Pro Asn Pro Ser Leu Arg Asp Ile Asp Thr Gln Ala Lys Tyr Gln
         595                 600                 605            
 Ser Tyr Phe Ser Arg Gly Gly Ala Lys Phe Ile Gly Met Ile Val Ser
     610                 615                 620                
 Pro Tyr Asn Arg Asn Asn Pro Leu Pro Tyr Ser Gln Ile Thr Cys Leu
 625                 630                 635                 640
 Val Ile Ser Glu Glu Ile Ser Pro Asp Gly Ser Tyr Arg Leu Pro Tyr
                 645                 650                 655    
 Lys Phe Glu Val Gln Gln Met Leu Glu Glu Pro Gln Trp Gly Leu Val
             660                 665                 670        
 Phe Glu Lys Thr Arg Trp Ile Ile Glu Lys Tyr Arg Leu Ser His Arg
         675                 680                 685            
 Ser Gly Val Glu Val Cys Asp Met Gln Thr Val Ser Thr Val Arg Thr
     690                 695                 700                
 Ser Ala Ala Leu Asn Pro Thr Glu Glu Thr Val Ala Ser Thr Cys Gln
 705                 710                 715                 720
 Pro Glu Gln Val Ser Ser Ala Leu Pro Ser Ser His Phe Ser Ser Trp
                 725                 730                 735    
 Val Leu Met Arg Leu Leu Gln Val Ile Ala Thr Cys Pro Lys Ala Pro
             740                 745                 750        
 Val Ala Gln Met Glu Gly Ser Met Pro Ser Glu Tyr Arg Arg Ala Gly
         755                 760                 765            
 Lys Gly Thr Gln Ala Pro Arg Leu Ala Glu Asn Phe Cys Val Cys His
     770                 775                 780                
 Leu Ala Thr Gly Asp Met Leu Arg Ala Met Val Ala Ser Gly Ser Glu
 785                 790                 795                 800
 Leu Gly Lys Lys Leu Lys Ala Thr Met Asp Ala Gly Lys Leu Val Ser
                 805                 810                 815    
 Asp Glu Met Val Val Glu Leu Ile Glu Lys Asn Leu Glu Thr Pro Leu
             820                 825                 830        
 Cys Lys Asn Gly Phe Leu Leu Asp Gly Phe Pro Arg Thr Val Arg Gln
         835                 840                 845            
 Ala Glu Met Leu Asp Asp Leu Met Glu Lys Arg Lys Glu Lys Leu Asp
     850                 855                 860                
 Ser Val Ile Glu Phe Ser Ile Pro Asp Ser Leu Leu Ile Arg Arg Ile
 865                 870                 875                 880
 Thr Gly Arg Leu Ile His Pro Lys Ser Gly Arg Ser Tyr His Glu Glu
                 885                 890                 895    
 Phe Asn Pro Pro Lys Glu Pro Met Lys Asp Asp Ile Thr Gly Glu Pro
             900                 905                 910        
 Leu Ile Arg Arg Ser Asp Asp Asn Glu Lys Ala Leu Lys Ile Arg Leu
         915                 920                 925            
 Gln Ala Tyr His Thr Gln Thr Thr Pro Leu Ile Glu Tyr Tyr Arg Lys
     930                 935                 940                
 Arg Gly Ile His Ser Ala Ile Asp Ala Ser Gln Thr Pro Asp Val Val
 945                 950                 955                 960
 Phe Ala Ser Ile Leu Ala Ala Phe Ser Lys Ala Thr Cys Lys Asp Leu
                 965                 970                 975    
 Val Met Phe Ile
             980



      <210> 415
      <211> 4097
      <212> PRT
      <213> Homo sapiens


      <400> 415
 Met Ala Gly Ser Gly Ala Gly Val Arg Cys Ser Leu Leu Arg Leu Gln
   1               5                  10                  15    
 Glu Thr Leu Ser Ala Ala Asp Arg Cys Gly Ala Ala Leu Ala Gly His
              20                  25                  30        
 Gln Leu Ile Arg Gly Leu Gly Gln Glu Cys Val Leu Ser Ser Ser Pro
          35                  40                  45            
 Ala Val Leu Ala Leu Gln Thr Ser Leu Val Phe Ser Arg Asp Phe Gly
      50                  55                  60                
 Leu Leu Val Phe Val Arg Lys Ser Leu Asn Ser Ile Glu Phe Arg Glu
  65                  70                  75                  80
 Cys Arg Glu Glu Ile Leu Lys Phe Leu Cys Ile Phe Leu Glu Lys Met
                  85                  90                  95    
 Gly Gln Lys Ile Ala Pro Tyr Ser Val Glu Ile Lys Asn Thr Cys Thr
             100                 105                 110        
 Ser Val Tyr Thr Lys Asp Arg Ala Ala Lys Cys Lys Ile Pro Ala Leu
         115                 120                 125            
 Asp Leu Leu Ile Lys Leu Leu Gln Thr Phe Arg Ser Ser Arg Leu Met
     130                 135                 140                
 Asp Glu Phe Lys Ile Gly Glu Leu Phe Ser Lys Phe Tyr Gly Glu Leu
 145                 150                 155                 160
 Ala Leu Lys Lys Lys Ile Pro Asp Thr Val Leu Glu Lys Val Tyr Glu
                 165                 170                 175    
 Leu Leu Gly Leu Leu Gly Glu Val His Pro Ser Glu Met Ile Asn Asn
             180                 185                 190        
 Ala Glu Asn Leu Phe Arg Ala Phe Leu Gly Glu Leu Lys Thr Gln Met
         195                 200                 205            
 Thr Ser Ala Val Arg Glu Pro Lys Leu Pro Val Leu Ala Gly Cys Leu
     210                 215                 220                
 Lys Gly Leu Ser Ser Leu Leu Cys Asn Phe Thr Lys Ser Met Glu Glu
 225                 230                 235                 240
 Asp Pro Gln Thr Ser Arg Glu Ile Phe Asn Phe Val Leu Lys Ala Ile
                 245                 250                 255    
 Arg Pro Gln Ile Asp Leu Lys Arg Tyr Ala Val Pro Ser Ala Gly Leu
             260                 265                 270        
 Arg Leu Phe Ala Leu His Ala Ser Gln Phe Ser Thr Cys Leu Leu Asp
         275                 280                 285            
 Asn Tyr Val Ser Leu Phe Glu Val Leu Leu Lys Trp Cys Ala His Thr
     290                 295                 300                
 Asn Val Glu Leu Lys Lys Ala Ala Leu Ser Ala Leu Glu Ser Phe Leu
 305                 310                 315                 320
 Lys Gln Val Ser Asn Met Val Ala Lys Asn Ala Glu Met His Lys Asn
                 325                 330                 335    
 Lys Leu Gln Tyr Phe Met Glu Gln Phe Tyr Gly Ile Ile Arg Asn Val
             340                 345                 350        
 Asp Ser Asn Asn Lys Glu Leu Ser Ile Ala Ile Arg Gly Tyr Gly Leu
         355                 360                 365            
 Phe Ala Gly Pro Cys Lys Val Ile Asn Ala Lys Asp Val Asp Phe Met
     370                 375                 380                
 Tyr Val Glu Leu Ile Gln Arg Cys Lys Gln Met Phe Leu Thr Gln Thr
 385                 390                 395                 400
 Asp Thr Gly Asp Tyr Arg Val Tyr Gln Met Pro Ser Phe Leu Gln Ser
                 405                 410                 415    
 Val Ala Ser Val Leu Leu Tyr Leu Asp Thr Val Pro Glu Val Tyr Thr
             420                 425                 430        
 Pro Val Leu Glu His Leu Val Val Met Gln Ile Asp Ser Phe Pro Gln
         435                 440                 445            
 Tyr Ser Pro Lys Met Gln Leu Val Cys Cys Arg Ala Ile Val Lys Val
     450                 455                 460                
 Phe Leu Ala Leu Ala Ala Lys Gly Pro Val Leu Arg Asn Cys Ile Ser
 465                 470                 475                 480
 Thr Val Val His Gln Gly Leu Ile Arg Ile Cys Ser Lys Pro Val Val
                 485                 490                 495    
 Leu Pro Lys Gly Pro Glu Ser Glu Ser Glu Asp His Arg Ala Ser Gly
             500                 505                 510        
 Glu Val Arg Thr Gly Lys Trp Lys Val Pro Thr Tyr Lys Asp Tyr Val
         515                 520                 525            
 Asp Leu Phe Arg His Leu Leu Ser Ser Asp Gln Met Met Asp Ser Ile
     530                 535                 540                
 Leu Ala Asp Glu Ala Phe Phe Ser Val Asn Ser Ser Ser Glu Ser Leu
 545                 550                 555                 560
 Asn His Leu Leu Tyr Asp Glu Phe Val Lys Ser Val Leu Lys Ile Val
                 565                 570                 575    
 Glu Lys Leu Asp Leu Thr Leu Glu Ile Gln Thr Val Gly Glu Gln Glu
             580                 585                 590        
 Asn Gly Asp Glu Ala Pro Gly Val Trp Met Ile Pro Thr Ser Asp Pro
         595                 600                 605            
 Ala Ala Asn Leu His Pro Ala Lys Pro Lys Asp Phe Ser Ala Phe Ile
     610                 615                 620                
 Asn Leu Val Glu Phe Cys Arg Glu Ile Leu Pro Glu Lys Gln Ala Glu
 625                 630                 635                 640
 Phe Phe Glu Pro Trp Val Tyr Ser Phe Ser Tyr Glu Leu Ile Leu Gln
                 645                 650                 655    
 Ser Thr Arg Leu Pro Leu Ile Ser Gly Phe Tyr Lys Leu Leu Ser Ile
             660                 665                 670        
 Thr Val Arg Asn Ala Lys Lys Ile Lys Tyr Phe Glu Gly Val Ser Pro
         675                 680                 685            
 Lys Ser Leu Lys His Ser Pro Glu Asp Pro Glu Lys Tyr Ser Cys Phe
     690                 695                 700                
 Ala Leu Phe Val Lys Phe Gly Lys Glu Val Ala Val Lys Met Lys Gln
 705                 710                 715                 720
 Tyr Lys Asp Glu Leu Leu Ala Ser Cys Leu Thr Phe Leu Leu Ser Leu
                 725                 730                 735    
 Pro His Asn Ile Ile Glu Leu Asp Val Arg Ala Tyr Val Pro Ala Leu
             740                 745                 750        
 Gln Met Ala Phe Lys Leu Gly Leu Ser Tyr Thr Pro Leu Ala Glu Val
         755                 760                 765            
 Gly Leu Asn Ala Leu Glu Glu Trp Ser Ile Tyr Ile Asp Arg His Val
     770                 775                 780                
 Met Gln Pro Tyr Tyr Lys Asp Ile Leu Pro Cys Leu Asp Gly Tyr Leu
 785                 790                 795                 800
 Lys Thr Ser Ala Leu Ser Asp Glu Thr Lys Asn Asn Trp Glu Val Ser
                 805                 810                 815    
 Ala Leu Ser Arg Ala Ala Gln Lys Gly Phe Asn Lys Val Val Leu Lys
             820                 825                 830        
 His Leu Lys Lys Thr Lys Asn Leu Ser Ser Asn Glu Ala Ile Ser Leu
         835                 840                 845            
 Glu Glu Ile Arg Ile Arg Val Val Gln Met Leu Gly Ser Leu Gly Gly
     850                 855                 860                
 Gln Ile Asn Lys Asn Leu Leu Thr Val Thr Ser Ser Asp Glu Met Met
 865                 870                 875                 880
 Lys Ser Tyr Val Ala Trp Asp Arg Glu Lys Arg Leu Ser Phe Ala Val
                 885                 890                 895    
 Pro Phe Arg Glu Met Lys Pro Val Ile Phe Leu Asp Val Phe Leu Pro
             900                 905                 910        
 Arg Val Thr Glu Leu Ala Leu Thr Ala Ser Asp Arg Gln Thr Lys Val
         915                 920                 925            
 Ala Ala Cys Glu Leu Leu His Ser Met Val Met Phe Met Leu Gly Lys
     930                 935                 940                
 Ala Thr Gln Met Pro Glu Gly Gly Gln Gly Ala Pro Pro Met Tyr Gln
 945                 950                 955                 960
 Leu Tyr Lys Arg Thr Phe Pro Val Leu Leu Arg Leu Ala Cys Asp Val
                 965                 970                 975    
 Asp Gln Val Thr Arg Gln Leu Tyr Glu Pro Leu Val Met Gln Leu Ile
             980                 985                 990        
 His Trp Phe Thr Asn Asn Lys Lys Phe Glu Ser Gln Asp Thr Val Ser
         995                1000                1005            
 Leu Leu Glu Ala Ile Leu Asp Gly Ile Val Asp Pro Val Asp Ser Thr
    1010                1015                1020                
 Leu Arg Asp Phe Cys Gly Arg Cys Ile Arg Glu Phe Leu Lys Trp Ser
1025                1030                1035                1040
 Ile Lys Gln Ile Thr Pro Gln Gln Gln Glu Lys Ser Pro Val Asn Thr
                1045                1050                1055    
 Lys Ser Leu Phe Lys Arg Leu Tyr Ser Leu Ala Leu His Pro Asn Ala
            1060                1065                1070        
 Phe Lys Arg Leu Gly Ala Ser Leu Ala Phe Asn Asn Ile Tyr Arg Glu
        1075                1080                1085            
 Phe Arg Glu Glu Glu Ser Leu Val Glu Gln Phe Val Phe Glu Ala Leu
    1090                1095                1100                
 Val Ile Tyr Met Glu Ser Leu Ala Leu Ala His Ala Asp Glu Lys Ser
1105                1110                1115                1120
 Leu Gly Thr Ile Gln Gln Cys Cys Asp Ala Ile Asp His Leu Cys Arg
                1125                1130                1135    
 Ile Ile Glu Lys Lys His Val Ser Leu Asn Lys Ala Lys Lys Arg Arg
            1140                1145                1150        
 Leu Pro Arg Gly Phe Pro Pro Ser Ala Ser Leu Cys Leu Leu Asp Leu
        1155                1160                1165            
 Val Lys Trp Leu Leu Ala His Cys Gly Arg Pro Gln Thr Glu Cys Arg
    1170                1175                1180                
 His Lys Ser Ile Glu Leu Phe Tyr Lys Phe Val Pro Leu Leu Pro Gly
1185                1190                1195                1200
 Asn Arg Ser Pro Asn Leu Trp Leu Lys Asp Val Leu Lys Glu Glu Gly
                1205                1210                1215    
 Val Ser Phe Leu Ile Asn Thr Phe Glu Gly Gly Gly Cys Gly Gln Pro
            1220                1225                1230        
 Ser Gly Ile Leu Ala Gln Pro Thr Leu Leu Tyr Leu Arg Gly Pro Phe
        1235                1240                1245            
 Ser Leu Gln Ala Thr Leu Cys Trp Leu Asp Leu Leu Leu Ala Ala Leu
    1250                1255                1260                
 Glu Cys Tyr Asn Thr Phe Ile Gly Glu Arg Thr Val Gly Ala Leu Gln
1265                1270                1275                1280
 Val Leu Gly Thr Glu Ala Gln Ser Ser Leu Leu Lys Ala Val Ala Phe
                1285                1290                1295    
 Phe Leu Glu Ser Ile Ala Met His Asp Ile Ile Ala Ala Glu Lys Cys
            1300                1305                1310        
 Phe Gly Thr Gly Ala Ala Gly Asn Arg Thr Ser Pro Gln Glu Gly Glu
        1315                1320                1325            
 Arg Tyr Asn Tyr Ser Lys Cys Thr Val Val Val Arg Ile Met Glu Phe
    1330                1335                1340                
 Thr Thr Thr Leu Leu Asn Thr Ser Pro Glu Gly Trp Lys Leu Leu Lys
1345                1350                1355                1360
 Lys Asp Leu Cys Asn Thr His Leu Met Arg Val Leu Val Gln Thr Leu
                1365                1370                1375    
 Cys Glu Pro Ala Ser Ile Gly Phe Asn Ile Gly Asp Val Gln Val Met
            1380                1385                1390        
 Ala His Leu Pro Asp Val Cys Val Asn Leu Met Lys Ala Leu Lys Met
        1395                1400                1405            
 Ser Pro Tyr Lys Asp Ile Leu Glu Thr His Leu Arg Glu Lys Ile Thr
    1410                1415                1420                
 Ala Gln Ser Ile Glu Glu Leu Cys Ala Val Asn Leu Tyr Gly Pro Asp
1425                1430                1435                1440
 Ala Gln Val Asp Arg Ser Arg Leu Ala Ala Val Val Ser Ala Cys Lys
                1445                1450                1455    
 Gln Leu His Arg Ala Gly Leu Leu His Asn Ile Leu Pro Ser Gln Ser
            1460                1465                1470        
 Thr Asp Leu His His Ser Val Gly Thr Glu Leu Leu Ser Leu Val Tyr
        1475                1480                1485            
 Lys Gly Ile Ala Pro Gly Asp Glu Arg Gln Cys Leu Pro Ser Leu Asp
    1490                1495                1500                
 Leu Ser Cys Lys Gln Leu Ala Ser Gly Leu Leu Glu Leu Ala Phe Ala
1505                1510                1515                1520
 Phe Gly Gly Leu Cys Glu Arg Leu Val Ser Leu Leu Leu Asn Pro Ala
                1525                1530                1535    
 Val Leu Ser Thr Ala Ser Leu Gly Ser Ser Gln Gly Ser Val Ile His
            1540                1545                1550        
 Phe Ser His Gly Glu Tyr Phe Tyr Ser Leu Phe Ser Glu Thr Ile Asn
        1555                1560                1565            
 Thr Glu Leu Leu Lys Asn Leu Asp Leu Ala Val Leu Glu Leu Met Gln
    1570                1575                1580                
 Ser Ser Val Asp Asn Thr Lys Met Val Ser Ala Val Leu Asn Gly Met
1585                1590                1595                1600
 Leu Asp Gln Ser Phe Arg Glu Arg Ala Asn Gln Lys His Gln Gly Leu
                1605                1610                1615    
 Lys Leu Ala Thr Thr Ile Leu Gln His Trp Lys Lys Cys Asp Ser Trp
            1620                1625                1630        
 Trp Ala Lys Asp Ser Pro Leu Glu Thr Lys Met Ala Val Leu Ala Leu
        1635                1640                1645            
 Leu Ala Lys Ile Leu Gln Ile Asp Ser Ser Val Ser Phe Asn Thr Ser
    1650                1655                1660                
 His Gly Ser Phe Pro Glu Val Phe Thr Thr Tyr Ile Ser Leu Leu Ala
1665                1670                1675                1680
 Asp Thr Lys Leu Asp Leu His Leu Lys Gly Gln Ala Val Thr Leu Leu
                1685                1690                1695    
 Pro Phe Phe Thr Ser Leu Thr Gly Gly Ser Leu Glu Glu Leu Arg Arg
            1700                1705                1710        
 Val Leu Glu Gln Leu Ile Val Ala His Phe Pro Met Gln Ser Arg Glu
        1715                1720                1725            
 Phe Pro Pro Gly Thr Pro Arg Phe Asn Asn Tyr Val Asp Cys Met Lys
    1730                1735                1740                
 Lys Phe Leu Asp Ala Leu Glu Leu Ser Gln Ser Pro Met Leu Leu Glu
1745                1750                1755                1760
 Leu Met Thr Glu Val Leu Cys Arg Glu Gln Gln His Val Met Glu Glu
                1765                1770                1775    
 Leu Phe Gln Ser Ser Phe Arg Arg Ile Ala Arg Arg Gly Ser Cys Val
            1780                1785                1790        
 Thr Gln Val Gly Leu Leu Glu Ser Val Tyr Glu Met Phe Arg Lys Asp
        1795                1800                1805            
 Asp Pro Arg Leu Ser Phe Thr Arg Gln Ser Phe Val Asp Arg Ser Leu
    1810                1815                1820                
 Leu Thr Leu Leu Trp His Cys Ser Leu Asp Ala Leu Arg Glu Phe Phe
1825                1830                1835                1840
 Ser Thr Ile Val Val Asp Ala Ile Asp Val Leu Lys Ser Arg Phe Thr
                1845                1850                1855    
 Lys Leu Asn Glu Ser Thr Phe Asp Thr Gln Ile Thr Lys Lys Met Gly
            1860                1865                1870        
 Tyr Tyr Lys Ile Leu Asp Val Met Tyr Ser Arg Leu Pro Lys Asp Asp
        1875                1880                1885            
 Val His Ala Lys Glu Ser Lys Ile Asn Gln Val Phe His Gly Ser Cys
    1890                1895                1900                
 Ile Thr Glu Gly Asn Glu Leu Thr Lys Thr Leu Ile Lys Leu Cys Tyr
1905                1910                1915                1920
 Asp Ala Phe Thr Glu Asn Met Ala Gly Glu Asn Gln Leu Leu Glu Arg
                1925                1930                1935    
 Arg Arg Leu Tyr His Cys Ala Ala Tyr Asn Cys Ala Ile Ser Val Ile
            1940                1945                1950        
 Cys Cys Val Phe Asn Glu Leu Lys Phe Tyr Gln Gly Phe Leu Phe Ser
        1955                1960                1965            
 Glu Lys Pro Glu Lys Asn Leu Leu Ile Phe Glu Asn Leu Ile Asp Leu
    1970                1975                1980                
 Lys Arg Arg Tyr Asn Phe Pro Val Glu Val Glu Val Pro Met Glu Arg
1985                1990                1995                2000
 Lys Lys Lys Tyr Ile Glu Ile Arg Lys Glu Ala Arg Glu Ala Ala Asn
                2005                2010                2015    
 Gly Asp Ser Asp Gly Pro Ser Tyr Met Ser Ser Leu Ser Tyr Leu Ala
            2020                2025                2030        
 Asp Ser Thr Leu Ser Glu Glu Met Ser Gln Phe Asp Phe Ser Thr Gly
        2035                2040                2045            
 Val Gln Ser Tyr Ser Tyr Ser Ser Gln Asp Pro Arg Pro Ala Thr Gly
    2050                2055                2060                
 Arg Phe Arg Arg Arg Glu Gln Arg Asp Pro Thr Val His Asp Asp Val
2065                2070                2075                2080
 Leu Glu Leu Glu Met Asp Glu Leu Asn Arg His Glu Cys Met Ala Pro
                2085                2090                2095    
 Leu Thr Ala Leu Val Lys His Met His Arg Ser Leu Gly Pro Pro Gln
            2100                2105                2110        
 Gly Glu Glu Asp Ser Val Pro Arg Asp Leu Pro Ser Trp Met Lys Phe
        2115                2120                2125            
 Leu His Gly Lys Leu Gly Asn Pro Ile Val Pro Leu Asn Ile Arg Leu
    2130                2135                2140                
 Phe Leu Ala Lys Leu Val Ile Asn Thr Glu Glu Val Phe Arg Pro Tyr
2145                2150                2155                2160
 Ala Lys His Trp Leu Ser Pro Leu Leu Gln Leu Ala Ala Ser Glu Asn
                2165                2170                2175    
 Asn Gly Gly Glu Gly Ile His Tyr Met Val Val Glu Ile Val Ala Thr
            2180                2185                2190        
 Ile Leu Ser Trp Thr Gly Leu Ala Thr Pro Thr Gly Val Pro Lys Asp
        2195                2200                2205            
 Glu Val Leu Ala Asn Arg Leu Leu Asn Phe Leu Met Lys His Val Phe
    2210                2215                2220                
 His Pro Lys Arg Ala Val Phe Arg His Asn Leu Glu Ile Ile Lys Thr
2225                2230                2235                2240
 Leu Val Glu Cys Trp Lys Asp Cys Leu Ser Ile Pro Tyr Arg Leu Ile
                2245                2250                2255    
 Phe Glu Lys Phe Ser Gly Lys Asp Pro Asn Ser Lys Asp Asn Ser Val
            2260                2265                2270        
 Gly Ile Gln Leu Leu Gly Ile Val Met Ala Asn Asp Leu Pro Pro Tyr
        2275                2280                2285            
 Asp Pro Gln Cys Gly Ile Gln Ser Ser Glu Tyr Phe Gln Ala Leu Val
    2290                2295                2300                
 Asn Asn Met Ser Phe Val Arg Tyr Lys Glu Val Tyr Ala Ala Ala Ala
2305                2310                2315                2320
 Glu Val Leu Gly Leu Ile Leu Arg Tyr Val Met Glu Arg Lys Asn Ile
                2325                2330                2335    
 Leu Glu Glu Ser Leu Cys Glu Leu Val Ala Lys Gln Leu Lys Gln His
            2340                2345                2350        
 Gln Asn Thr Met Glu Asp Lys Phe Ile Val Cys Leu Asn Lys Val Thr
        2355                2360                2365            
 Lys Ser Phe Pro Pro Leu Ala Asp Arg Phe Met Asn Ala Val Phe Phe
    2370                2375                2380                
 Leu Leu Pro Lys Phe His Gly Val Leu Lys Thr Leu Cys Leu Glu Val
2385                2390                2395                2400
 Val Leu Cys Arg Val Glu Gly Met Thr Glu Leu Tyr Phe Gln Leu Lys
                2405                2410                2415    
 Ser Lys Asp Phe Val Gln Val Met Arg His Arg Asp Asp Glu Arg Gln
            2420                2425                2430        
 Lys Val Cys Leu Asp Ile Ile Tyr Lys Met Met Pro Lys Leu Lys Pro
        2435                2440                2445            
 Val Glu Leu Arg Glu Leu Leu Asn Pro Val Val Glu Phe Val Ser His
    2450                2455                2460                
 Pro Ser Thr Thr Cys Arg Glu Gln Met Tyr Asn Ile Leu Met Trp Ile
2465                2470                2475                2480
 His Asp Asn Tyr Arg Asp Pro Glu Ser Glu Thr Asp Asn Asp Ser Gln
                2485                2490                2495    
 Glu Ile Phe Lys Leu Ala Lys Asp Val Leu Ile Gln Gly Leu Ile Asp
            2500                2505                2510        
 Glu Asn Pro Gly Leu Gln Leu Ile Ile Arg Asn Phe Trp Ser His Glu
        2515                2520                2525            
 Thr Arg Leu Pro Ser Asn Thr Leu Asp Arg Leu Leu Ala Leu Asn Ser
    2530                2535                2540                
 Leu Tyr Ser Pro Lys Ile Glu Val His Phe Leu Ser Leu Ala Thr Asn
2545                2550                2555                2560
 Phe Leu Leu Glu Met Thr Ser Met Ser Pro Asp Tyr Pro Asn Pro Met
                2565                2570                2575    
 Phe Glu His Pro Leu Ser Glu Cys Glu Phe Gln Glu Tyr Thr Ile Asp
            2580                2585                2590        
 Ser Asp Trp Arg Phe Arg Ser Thr Val Leu Thr Pro Met Phe Val Glu
        2595                2600                2605            
 Thr Gln Ala Ser Gln Gly Thr Leu Gln Thr Arg Thr Gln Glu Gly Ser
    2610                2615                2620                
 Leu Ser Ala Arg Trp Pro Val Ala Gly Gln Ile Arg Ala Thr Gln Gln
2625                2630                2635                2640
 Gln His Asp Phe Thr Leu Thr Gln Thr Ala Asp Gly Arg Ser Ser Phe
                2645                2650                2655    
 Asp Trp Leu Thr Gly Ser Ser Thr Asp Pro Leu Val Asp His Thr Ser
            2660                2665                2670        
 Pro Ser Ser Asp Ser Leu Leu Phe Ala His Lys Arg Ser Glu Arg Leu
        2675                2680                2685            
 Gln Arg Ala Pro Leu Lys Ser Val Gly Pro Asp Phe Gly Lys Lys Arg
    2690                2695                2700                
 Leu Gly Leu Pro Gly Asp Glu Val Asp Asn Lys Val Lys Gly Ala Ala
2705                2710                2715                2720
 Gly Arg Thr Asp Leu Leu Arg Leu Arg Arg Arg Phe Met Arg Asp Gln
                2725                2730                2735    
 Glu Lys Leu Ser Leu Met Tyr Ala Arg Lys Gly Val Ala Glu Gln Lys
            2740                2745                2750        
 Arg Glu Lys Glu Ile Lys Ser Glu Leu Lys Met Lys Gln Asp Ala Gln
        2755                2760                2765            
 Val Val Leu Tyr Arg Ser Tyr Arg His Gly Asp Leu Pro Asp Ile Gln
    2770                2775                2780                
 Ile Lys His Ser Ser Leu Ile Thr Pro Leu Gln Ala Val Ala Gln Arg
2785                2790                2795                2800
 Asp Pro Ile Ile Ala Lys Gln Leu Phe Ser Ser Leu Phe Ser Gly Ile
                2805                2810                2815    
 Leu Lys Glu Met Asp Lys Phe Lys Thr Leu Ser Glu Lys Asn Asn Ile
            2820                2825                2830        
 Thr Gln Lys Leu Leu Gln Asp Phe Asn Arg Phe Leu Asn Thr Thr Phe
        2835                2840                2845            
 Ser Phe Phe Pro Pro Phe Val Ser Cys Ile Gln Asp Ile Ser Cys Gln
    2850                2855                2860                
 His Ala Ala Leu Leu Ser Leu Asp Pro Ala Ala Val Ser Ala Gly Cys
2865                2870                2875                2880
 Leu Ala Ser Leu Gln Gln Pro Val Gly Ile Arg Leu Leu Glu Glu Ala
                2885                2890                2895    
 Leu Leu Arg Leu Leu Pro Ala Glu Leu Pro Ala Lys Arg Val Arg Gly
            2900                2905                2910        
 Lys Ala Arg Leu Pro Pro Asp Val Leu Arg Trp Val Glu Leu Ala Lys
        2915                2920                2925            
 Leu Tyr Arg Ser Ile Gly Glu Tyr Asp Val Leu Arg Gly Ile Phe Thr
    2930                2935                2940                
 Ser Glu Ile Gly Thr Lys Gln Ile Thr Gln Ser Ala Leu Leu Ala Glu
2945                2950                2955                2960
 Ala Arg Ser Asp Tyr Ser Glu Ala Ala Lys Gln Tyr Asp Glu Ala Leu
                2965                2970                2975    
 Asn Lys Gln Asp Trp Val Asp Gly Glu Pro Thr Glu Ala Glu Lys Asp
            2980                2985                2990        
 Phe Trp Glu Leu Ala Ser Leu Asp Cys Tyr Asn His Leu Ala Glu Trp
        2995                3000                3005            
 Lys Ser Leu Glu Tyr Cys Ser Thr Ala Ser Ile Asp Ser Glu Asn Pro
    3010                3015                3020                
 Pro Asp Leu Asn Lys Ile Trp Ser Glu Pro Phe Tyr Gln Glu Thr Tyr
3025                3030                3035                3040
 Leu Pro Tyr Met Ile Arg Ser Lys Leu Lys Leu Leu Leu Gln Gly Glu
                3045                3050                3055    
 Ala Asp Gln Ser Leu Leu Thr Phe Ile Asp Lys Ala Met His Gly Glu
            3060                3065                3070        
 Leu Gln Lys Ala Ile Leu Glu Leu His Tyr Ser Gln Glu Leu Ser Leu
        3075                3080                3085            
 Leu Tyr Leu Leu Gln Asp Asp Val Asp Arg Ala Lys Tyr Tyr Ile Gln
    3090                3095                3100                
 Asn Gly Ile Gln Ser Phe Met Gln Asn Tyr Ser Ser Ile Asp Val Leu
3105                3110                3115                3120
 Leu His Gln Ser Arg Leu Thr Lys Leu Gln Ser Val Gln Ala Leu Thr
                3125                3130                3135    
 Glu Ile Gln Glu Phe Ile Ser Phe Ile Ser Lys Gln Gly Asn Leu Ser
            3140                3145                3150        
 Ser Gln Val Pro Leu Lys Arg Leu Leu Asn Thr Trp Thr Asn Arg Tyr
        3155                3160                3165            
 Pro Asp Ala Lys Met Asp Pro Met Asn Ile Trp Asp Asp Ile Ile Thr
    3170                3175                3180                
 Asn Arg Cys Phe Phe Leu Ser Lys Ile Glu Glu Lys Leu Thr Pro Leu
3185                3190                3195                3200
 Pro Glu Asp Asn Ser Met Asn Val Asp Gln Asp Gly Asp Pro Ser Asp
                3205                3210                3215    
 Arg Met Glu Val Gln Glu Gln Glu Glu Asp Ile Ser Ser Leu Ile Arg
            3220                3225                3230        
 Ser Cys Lys Phe Ser Met Lys Met Lys Met Ile Asp Ser Ala Arg Lys
        3235                3240                3245            
 Gln Asn Asn Phe Ser Leu Ala Met Lys Leu Leu Lys Glu Leu His Lys
    3250                3255                3260                
 Glu Ser Lys Thr Arg Asp Asp Trp Leu Val Ser Trp Val Gln Ser Tyr
3265                3270                3275                3280
 Cys Arg Leu Ser His Cys Arg Ser Arg Ser Gln Gly Cys Ser Glu Gln
                3285                3290                3295    
 Val Leu Thr Val Leu Lys Thr Val Ser Leu Leu Asp Glu Asn Asn Val
            3300                3305                3310        
 Ser Ser Tyr Leu Ser Lys Asn Ile Leu Ala Phe Arg Asp Gln Asn Ile
        3315                3320                3325            
 Leu Leu Gly Thr Thr Tyr Arg Ile Ile Ala Asn Ala Leu Ser Ser Glu
    3330                3335                3340                
 Pro Ala Cys Leu Ala Glu Ile Glu Glu Asp Lys Ala Arg Arg Ile Leu
3345                3350                3355                3360
 Glu Leu Ser Gly Ser Ser Ser Glu Asp Ser Glu Lys Val Ile Ala Gly
                3365                3370                3375    
 Leu Tyr Gln Arg Ala Phe Gln His Leu Ser Glu Ala Val Gln Ala Ala
            3380                3385                3390        
 Glu Glu Glu Ala Gln Pro Pro Ser Trp Ser Cys Gly Pro Ala Ala Gly
        3395                3400                3405            
 Val Ile Asp Ala Tyr Met Thr Leu Ala Asp Phe Cys Asp Gln Gln Leu
    3410                3415                3420                
 Arg Lys Glu Glu Glu Asn Ala Ser Val Ile Asp Ser Ala Glu Leu Gln
3425                3430                3435                3440
 Ala Tyr Pro Ala Leu Val Val Glu Lys Met Leu Lys Ala Leu Lys Leu
                3445                3450                3455    
 Asn Ser Asn Glu Ala Arg Leu Lys Phe Pro Arg Leu Leu Gln Ile Ile
            3460                3465                3470        
 Glu Arg Tyr Pro Glu Glu Thr Leu Ser Leu Met Thr Lys Glu Ile Ser
        3475                3480                3485            
 Ser Val Pro Cys Trp Gln Phe Ile Ser Trp Ile Ser His Met Val Ala
    3490                3495                3500                
 Leu Leu Asp Lys Asp Gln Ala Val Ala Val Gln His Ser Val Glu Glu
3505                3510                3515                3520
 Ile Thr Asp Asn Tyr Pro Gln Ala Ile Val Tyr Pro Phe Ile Ile Ser
                3525                3530                3535    
 Ser Glu Ser Tyr Ser Phe Lys Asp Thr Ser Thr Gly His Lys Asn Lys
            3540                3545                3550        
 Glu Phe Val Ala Arg Ile Lys Ser Lys Leu Asp Gln Gly Gly Val Ile
        3555                3560                3565            
 Gln Asp Phe Ile Asn Ala Leu Asp Gln Leu Ser Asn Pro Glu Leu Leu
    3570                3575                3580                
 Phe Lys Asp Trp Ser Asn Asp Val Arg Ala Glu Leu Ala Lys Thr Pro
3585                3590                3595                3600
 Val Asn Lys Lys Asn Ile Glu Lys Met Tyr Glu Arg Met Tyr Ala Ala
                3605                3610                3615    
 Leu Gly Asp Pro Lys Ala Pro Gly Leu Gly Ala Phe Arg Arg Lys Phe
            3620                3625                3630        
 Ile Gln Thr Phe Gly Lys Glu Phe Asp Lys His Phe Gly Lys Gly Gly
        3635                3640                3645            
 Ser Lys Leu Leu Arg Met Lys Leu Ser Asp Phe Asn Asp Ile Thr Asn
    3650                3655                3660                
 Met Leu Leu Leu Lys Met Asn Lys Asp Ser Lys Pro Pro Gly Asn Leu
3665                3670                3675                3680
 Lys Glu Cys Ser Pro Trp Met Ser Asp Phe Lys Val Glu Phe Leu Arg
                3685                3690                3695    
 Asn Glu Leu Glu Ile Pro Gly Gln Tyr Asp Gly Arg Gly Lys Pro Leu
            3700                3705                3710        
 Pro Glu Tyr His Val Arg Ile Ala Gly Phe Asp Glu Arg Val Thr Val
        3715                3720                3725            
 Met Ala Ser Leu Arg Arg Pro Lys Arg Ile Ile Ile Arg Gly His Asp
    3730                3735                3740                
 Glu Arg Glu His Pro Phe Leu Val Lys Gly Gly Glu Asp Leu Arg Gln
3745                3750                3755                3760
 Asp Gln Arg Val Glu Gln Leu Phe Gln Val Met Asn Gly Ile Leu Ala
                3765                3770                3775    
 Gln Asp Ser Ala Cys Ser Gln Arg Ala Leu Gln Leu Arg Thr Tyr Ser
            3780                3785                3790        
 Val Val Pro Met Thr Ser Ser Asp Pro Arg Ala Pro Pro Cys Glu Tyr
        3795                3800                3805            
 Lys Asp Trp Leu Thr Lys Met Ser Gly Lys His Asp Val Gly Ala Tyr
    3810                3815                3820                
 Met Leu Met Tyr Lys Gly Ala Asn Arg Thr Glu Thr Val Thr Ser Phe
3825                3830                3835                3840
 Arg Lys Arg Glu Ser Lys Val Pro Ala Asp Leu Leu Lys Arg Ala Phe
                3845                3850                3855    
 Val Arg Met Ser Thr Ser Pro Glu Ala Phe Leu Ala Leu Arg Ser His
            3860                3865                3870        
 Phe Ala Ser Ser His Ala Leu Ile Cys Ile Ser His Trp Ile Leu Gly
        3875                3880                3885            
 Ile Gly Asp Arg His Leu Asn Asn Phe Met Val Ala Met Glu Thr Gly
    3890                3895                3900                
 Gly Val Ile Gly Ile Asp Phe Gly His Ala Phe Gly Ser Ala Thr Gln
3905                3910                3915                3920
 Phe Leu Pro Val Pro Glu Leu Met Pro Phe Arg Leu Thr Arg Gln Phe
                3925                3930                3935    
 Ile Asn Leu Met Leu Pro Met Lys Glu Thr Gly Leu Met Tyr Ser Ile
            3940                3945                3950        
 Met Val His Ala Leu Arg Ala Phe Arg Ser Asp Pro Gly Leu Leu Thr
        3955                3960                3965            
 Asn Thr Met Asp Val Phe Val Lys Glu Pro Ser Phe Asp Trp Lys Asn
    3970                3975                3980                
 Phe Glu Gln Lys Met Leu Lys Lys Gly Gly Ser Trp Ile Gln Glu Ile
3985                3990                3995                4000
 Asn Val Ala Glu Lys Asn Trp Tyr Pro Arg Gln Lys Ile Cys Tyr Ala
                4005                4010                4015    
 Lys Arg Lys Leu Ala Gly Ala Asn Pro Ala Val Ile Thr Cys Asp Glu
            4020                4025                4030        
 Leu Leu Leu Gly His Glu Lys Ala Pro Ala Phe Arg Asp Tyr Val Ala
        4035                4040                4045            
 Val Ala Arg Gly Ser Lys Asp His Asn Ile Arg Ala Gln Glu Pro Glu
    4050                4055                4060                
 Ser Gly Leu Ser Glu Glu Thr Gln Val Lys Cys Leu Met Asp Gln Ala
4065                4070                4075                4080
 Thr Asp Pro Asn Ile Leu Gly Arg Thr Trp Glu Gly Trp Glu Pro Trp
                4085                4090                4095    
 Met
    



      <210> 416
      <211> 4128
      <212> PRT
      <213> Homo sapiens


      <400> 416
 Met Ala Gly Ser Gly Ala Gly Val Arg Cys Ser Leu Leu Arg Leu Gln
   1               5                  10                  15    
 Glu Thr Leu Ser Ala Ala Asp Arg Cys Gly Ala Ala Leu Ala Gly His
              20                  25                  30        
 Gln Leu Ile Arg Gly Leu Gly Gln Glu Cys Val Leu Ser Ser Ser Pro
          35                  40                  45            
 Ala Val Leu Ala Leu Gln Thr Ser Leu Val Phe Ser Arg Asp Phe Gly
      50                  55                  60                
 Leu Leu Val Phe Val Arg Lys Ser Leu Asn Ser Ile Glu Phe Arg Glu
  65                  70                  75                  80
 Cys Arg Glu Glu Ile Leu Lys Phe Leu Cys Ile Phe Leu Glu Lys Met
                  85                  90                  95    
 Gly Gln Lys Ile Ala Pro Tyr Ser Val Glu Ile Lys Asn Thr Cys Thr
             100                 105                 110        
 Ser Val Tyr Thr Lys Asp Arg Ala Ala Lys Cys Lys Ile Pro Ala Leu
         115                 120                 125            
 Asp Leu Leu Ile Lys Leu Leu Gln Thr Phe Arg Ser Ser Arg Leu Met
     130                 135                 140                
 Asp Glu Phe Lys Ile Gly Glu Leu Phe Ser Lys Phe Tyr Gly Glu Leu
 145                 150                 155                 160
 Ala Leu Lys Lys Lys Ile Pro Asp Thr Val Leu Glu Lys Val Tyr Glu
                 165                 170                 175    
 Leu Leu Gly Leu Leu Gly Glu Val His Pro Ser Glu Met Ile Asn Asn
             180                 185                 190        
 Ala Glu Asn Leu Phe Arg Ala Phe Leu Gly Glu Leu Lys Thr Gln Met
         195                 200                 205            
 Thr Ser Ala Val Arg Glu Pro Lys Leu Pro Val Leu Ala Gly Cys Leu
     210                 215                 220                
 Lys Gly Leu Ser Ser Leu Leu Cys Asn Phe Thr Lys Ser Met Glu Glu
 225                 230                 235                 240
 Asp Pro Gln Thr Ser Arg Glu Ile Phe Asn Phe Val Leu Lys Ala Ile
                 245                 250                 255    
 Arg Pro Gln Ile Asp Leu Lys Arg Tyr Ala Val Pro Ser Ala Gly Leu
             260                 265                 270        
 Arg Leu Phe Ala Leu His Ala Ser Gln Phe Ser Thr Cys Leu Leu Asp
         275                 280                 285            
 Asn Tyr Val Ser Leu Phe Glu Val Leu Leu Lys Trp Cys Ala His Thr
     290                 295                 300                
 Asn Val Glu Leu Lys Lys Ala Ala Leu Ser Ala Leu Glu Ser Phe Leu
 305                 310                 315                 320
 Lys Gln Val Ser Asn Met Val Ala Lys Asn Ala Glu Met His Lys Asn
                 325                 330                 335    
 Lys Leu Gln Tyr Phe Met Glu Gln Phe Tyr Gly Ile Ile Arg Asn Val
             340                 345                 350        
 Asp Ser Asn Asn Lys Glu Leu Ser Ile Ala Ile Arg Gly Tyr Gly Leu
         355                 360                 365            
 Phe Ala Gly Pro Cys Lys Val Ile Asn Ala Lys Asp Val Asp Phe Met
     370                 375                 380                
 Tyr Val Glu Leu Ile Gln Arg Cys Lys Gln Met Phe Leu Thr Gln Thr
 385                 390                 395                 400
 Asp Thr Gly Asp Tyr Arg Val Tyr Gln Met Pro Ser Phe Leu Gln Ser
                 405                 410                 415    
 Val Ala Ser Val Leu Leu Tyr Leu Asp Thr Val Pro Glu Val Tyr Thr
             420                 425                 430        
 Pro Val Leu Glu His Leu Val Val Met Gln Ile Asp Ser Phe Pro Gln
         435                 440                 445            
 Tyr Ser Pro Lys Met Gln Leu Val Cys Cys Arg Ala Ile Val Lys Val
     450                 455                 460                
 Phe Leu Ala Leu Ala Ala Lys Gly Pro Val Leu Arg Asn Cys Ile Ser
 465                 470                 475                 480
 Thr Val Val His Gln Gly Leu Ile Arg Ile Cys Ser Lys Pro Val Val
                 485                 490                 495    
 Leu Pro Lys Gly Pro Glu Ser Glu Ser Glu Asp His Arg Ala Ser Gly
             500                 505                 510        
 Glu Val Arg Thr Gly Lys Trp Lys Val Pro Thr Tyr Lys Asp Tyr Val
         515                 520                 525            
 Asp Leu Phe Arg His Leu Leu Ser Ser Asp Gln Met Met Asp Ser Ile
     530                 535                 540                
 Leu Ala Asp Glu Ala Phe Phe Ser Val Asn Ser Ser Ser Glu Ser Leu
 545                 550                 555                 560
 Asn His Leu Leu Tyr Asp Glu Phe Val Lys Ser Val Leu Lys Ile Val
                 565                 570                 575    
 Glu Lys Leu Asp Leu Thr Leu Glu Ile Gln Thr Val Gly Glu Gln Glu
             580                 585                 590        
 Asn Gly Asp Glu Ala Pro Gly Val Trp Met Ile Pro Thr Ser Asp Pro
         595                 600                 605            
 Ala Ala Asn Leu His Pro Ala Lys Pro Lys Asp Phe Ser Ala Phe Ile
     610                 615                 620                
 Asn Leu Val Glu Phe Cys Arg Glu Ile Leu Pro Glu Lys Gln Ala Glu
 625                 630                 635                 640
 Phe Phe Glu Pro Trp Val Tyr Ser Phe Ser Tyr Glu Leu Ile Leu Gln
                 645                 650                 655    
 Ser Thr Arg Leu Pro Leu Ile Ser Gly Phe Tyr Lys Leu Leu Ser Ile
             660                 665                 670        
 Thr Val Arg Asn Ala Lys Lys Ile Lys Tyr Phe Glu Gly Val Ser Pro
         675                 680                 685            
 Lys Ser Leu Lys His Ser Pro Glu Asp Pro Glu Lys Tyr Ser Cys Phe
     690                 695                 700                
 Ala Leu Phe Val Lys Phe Gly Lys Glu Val Ala Val Lys Met Lys Gln
 705                 710                 715                 720
 Tyr Lys Asp Glu Leu Leu Ala Ser Cys Leu Thr Phe Leu Leu Ser Leu
                 725                 730                 735    
 Pro His Asn Ile Ile Glu Leu Asp Val Arg Ala Tyr Val Pro Ala Leu
             740                 745                 750        
 Gln Met Ala Phe Lys Leu Gly Leu Ser Tyr Thr Pro Leu Ala Glu Val
         755                 760                 765            
 Gly Leu Asn Ala Leu Glu Glu Trp Ser Ile Tyr Ile Asp Arg His Val
     770                 775                 780                
 Met Gln Pro Tyr Tyr Lys Asp Ile Leu Pro Cys Leu Asp Gly Tyr Leu
 785                 790                 795                 800
 Lys Thr Ser Ala Leu Ser Asp Glu Thr Lys Asn Asn Trp Glu Val Ser
                 805                 810                 815    
 Ala Leu Ser Arg Ala Ala Gln Lys Gly Phe Asn Lys Val Val Leu Lys
             820                 825                 830        
 His Leu Lys Lys Thr Lys Asn Leu Ser Ser Asn Glu Ala Ile Ser Leu
         835                 840                 845            
 Glu Glu Ile Arg Ile Arg Val Val Gln Met Leu Gly Ser Leu Gly Gly
     850                 855                 860                
 Gln Ile Asn Lys Asn Leu Leu Thr Val Thr Ser Ser Asp Glu Met Met
 865                 870                 875                 880
 Lys Ser Tyr Val Ala Trp Asp Arg Glu Lys Arg Leu Ser Phe Ala Val
                 885                 890                 895    
 Pro Phe Arg Glu Met Lys Pro Val Ile Phe Leu Asp Val Phe Leu Pro
             900                 905                 910        
 Arg Val Thr Glu Leu Ala Leu Thr Ala Ser Asp Arg Gln Thr Lys Val
         915                 920                 925            
 Ala Ala Cys Glu Leu Leu His Ser Met Val Met Phe Met Leu Gly Lys
     930                 935                 940                
 Ala Thr Gln Met Pro Glu Gly Gly Gln Gly Ala Pro Pro Met Tyr Gln
 945                 950                 955                 960
 Leu Tyr Lys Arg Thr Phe Pro Val Leu Leu Arg Leu Ala Cys Asp Val
                 965                 970                 975    
 Asp Gln Val Thr Arg Gln Leu Tyr Glu Pro Leu Val Met Gln Leu Ile
             980                 985                 990        
 His Trp Phe Thr Asn Asn Lys Lys Phe Glu Ser Gln Asp Thr Val Ser
         995                1000                1005            
 Leu Leu Glu Ala Ile Leu Asp Gly Ile Val Asp Pro Val Asp Ser Thr
    1010                1015                1020                
 Leu Arg Asp Phe Cys Gly Arg Cys Ile Arg Glu Phe Leu Lys Trp Ser
1025                1030                1035                1040
 Ile Lys Gln Ile Thr Pro Gln Gln Gln Glu Lys Ser Pro Val Asn Thr
                1045                1050                1055    
 Lys Ser Leu Phe Lys Arg Leu Tyr Ser Leu Ala Leu His Pro Asn Ala
            1060                1065                1070        
 Phe Lys Arg Leu Gly Ala Ser Leu Ala Phe Asn Asn Ile Tyr Arg Glu
        1075                1080                1085            
 Phe Arg Glu Glu Glu Ser Leu Val Glu Gln Phe Val Phe Glu Ala Leu
    1090                1095                1100                
 Val Ile Tyr Met Glu Ser Leu Ala Leu Ala His Ala Asp Glu Lys Ser
1105                1110                1115                1120
 Leu Gly Thr Ile Gln Gln Cys Cys Asp Ala Ile Asp His Leu Cys Arg
                1125                1130                1135    
 Ile Ile Glu Lys Lys His Val Ser Leu Asn Lys Ala Lys Lys Arg Arg
            1140                1145                1150        
 Leu Pro Arg Gly Phe Pro Pro Ser Ala Ser Leu Cys Leu Leu Asp Leu
        1155                1160                1165            
 Val Lys Trp Leu Leu Ala His Cys Gly Arg Pro Gln Thr Glu Cys Arg
    1170                1175                1180                
 His Lys Ser Ile Glu Leu Phe Tyr Lys Phe Val Pro Leu Leu Pro Gly
1185                1190                1195                1200
 Asn Arg Ser Pro Asn Leu Trp Leu Lys Asp Val Leu Lys Glu Glu Gly
                1205                1210                1215    
 Val Ser Phe Leu Ile Asn Thr Phe Glu Gly Gly Gly Cys Gly Gln Pro
            1220                1225                1230        
 Ser Gly Ile Leu Ala Gln Pro Thr Leu Leu Tyr Leu Arg Gly Pro Phe
        1235                1240                1245            
 Ser Leu Gln Ala Thr Leu Cys Trp Leu Asp Leu Leu Leu Ala Ala Leu
    1250                1255                1260                
 Glu Cys Tyr Asn Thr Phe Ile Gly Glu Arg Thr Val Gly Ala Leu Gln
1265                1270                1275                1280
 Val Leu Gly Thr Glu Ala Gln Ser Ser Leu Leu Lys Ala Val Ala Phe
                1285                1290                1295    
 Phe Leu Glu Ser Ile Ala Met His Asp Ile Ile Ala Ala Glu Lys Cys
            1300                1305                1310        
 Phe Gly Thr Gly Ala Ala Gly Asn Arg Thr Ser Pro Gln Glu Gly Glu
        1315                1320                1325            
 Arg Tyr Asn Tyr Ser Lys Cys Thr Val Val Val Arg Ile Met Glu Phe
    1330                1335                1340                
 Thr Thr Thr Leu Leu Asn Thr Ser Pro Glu Gly Trp Lys Leu Leu Lys
1345                1350                1355                1360
 Lys Asp Leu Cys Asn Thr His Leu Met Arg Val Leu Val Gln Thr Leu
                1365                1370                1375    
 Cys Glu Pro Ala Ser Ile Gly Phe Asn Ile Gly Asp Val Gln Val Met
            1380                1385                1390        
 Ala His Leu Pro Asp Val Cys Val Asn Leu Met Lys Ala Leu Lys Met
        1395                1400                1405            
 Ser Pro Tyr Lys Asp Ile Leu Glu Thr His Leu Arg Glu Lys Ile Thr
    1410                1415                1420                
 Ala Gln Ser Ile Glu Glu Leu Cys Ala Val Asn Leu Tyr Gly Pro Asp
1425                1430                1435                1440
 Ala Gln Val Asp Arg Ser Arg Leu Ala Ala Val Val Ser Ala Cys Lys
                1445                1450                1455    
 Gln Leu His Arg Ala Gly Leu Leu His Asn Ile Leu Pro Ser Gln Ser
            1460                1465                1470        
 Thr Asp Leu His His Ser Val Gly Thr Glu Leu Leu Ser Leu Val Tyr
        1475                1480                1485            
 Lys Gly Ile Ala Pro Gly Asp Glu Arg Gln Cys Leu Pro Ser Leu Asp
    1490                1495                1500                
 Leu Ser Cys Lys Gln Leu Ala Ser Gly Leu Leu Glu Leu Ala Phe Ala
1505                1510                1515                1520
 Phe Gly Gly Leu Cys Glu Arg Leu Val Ser Leu Leu Leu Asn Pro Ala
                1525                1530                1535    
 Val Leu Ser Thr Ala Ser Leu Gly Ser Ser Gln Gly Ser Val Ile His
            1540                1545                1550        
 Phe Ser His Gly Glu Tyr Phe Tyr Ser Leu Phe Ser Glu Thr Ile Asn
        1555                1560                1565            
 Thr Glu Leu Leu Lys Asn Leu Asp Leu Ala Val Leu Glu Leu Met Gln
    1570                1575                1580                
 Ser Ser Val Asp Asn Thr Lys Met Val Ser Ala Val Leu Asn Gly Met
1585                1590                1595                1600
 Leu Asp Gln Ser Phe Arg Glu Arg Ala Asn Gln Lys His Gln Gly Leu
                1605                1610                1615    
 Lys Leu Ala Thr Thr Ile Leu Gln His Trp Lys Lys Cys Asp Ser Trp
            1620                1625                1630        
 Trp Ala Lys Asp Ser Pro Leu Glu Thr Lys Met Ala Val Leu Ala Leu
        1635                1640                1645            
 Leu Ala Lys Ile Leu Gln Ile Asp Ser Ser Val Ser Phe Asn Thr Ser
    1650                1655                1660                
 His Gly Ser Phe Pro Glu Val Phe Thr Thr Tyr Ile Ser Leu Leu Ala
1665                1670                1675                1680
 Asp Thr Lys Leu Asp Leu His Leu Lys Gly Gln Ala Val Thr Leu Leu
                1685                1690                1695    
 Pro Phe Phe Thr Ser Leu Thr Gly Gly Ser Leu Glu Glu Leu Arg Arg
            1700                1705                1710        
 Val Leu Glu Gln Leu Ile Val Ala His Phe Pro Met Gln Ser Arg Glu
        1715                1720                1725            
 Phe Pro Pro Gly Thr Pro Arg Phe Asn Asn Tyr Val Asp Cys Met Lys
    1730                1735                1740                
 Lys Phe Leu Asp Ala Leu Glu Leu Ser Gln Ser Pro Met Leu Leu Glu
1745                1750                1755                1760
 Leu Met Thr Glu Val Leu Cys Arg Glu Gln Gln His Val Met Glu Glu
                1765                1770                1775    
 Leu Phe Gln Ser Ser Phe Arg Arg Ile Ala Arg Arg Gly Ser Cys Val
            1780                1785                1790        
 Thr Gln Val Gly Leu Leu Glu Ser Val Tyr Glu Met Phe Arg Lys Asp
        1795                1800                1805            
 Asp Pro Arg Leu Ser Phe Thr Arg Gln Ser Phe Val Asp Arg Ser Leu
    1810                1815                1820                
 Leu Thr Leu Leu Trp His Cys Ser Leu Asp Ala Leu Arg Glu Phe Phe
1825                1830                1835                1840
 Ser Thr Ile Val Val Asp Ala Ile Asp Val Leu Lys Ser Arg Phe Thr
                1845                1850                1855    
 Lys Leu Asn Glu Ser Thr Phe Asp Thr Gln Ile Thr Lys Lys Met Gly
            1860                1865                1870        
 Tyr Tyr Lys Ile Leu Asp Val Met Tyr Ser Arg Leu Pro Lys Asp Asp
        1875                1880                1885            
 Val His Ala Lys Glu Ser Lys Ile Asn Gln Val Phe His Gly Ser Cys
    1890                1895                1900                
 Ile Thr Glu Gly Asn Glu Leu Thr Lys Thr Leu Ile Lys Leu Cys Tyr
1905                1910                1915                1920
 Asp Ala Phe Thr Glu Asn Met Ala Gly Glu Asn Gln Leu Leu Glu Arg
                1925                1930                1935    
 Arg Arg Leu Tyr His Cys Ala Ala Tyr Asn Cys Ala Ile Ser Val Ile
            1940                1945                1950        
 Cys Cys Val Phe Asn Glu Leu Lys Phe Tyr Gln Gly Phe Leu Phe Ser
        1955                1960                1965            
 Glu Lys Pro Glu Lys Asn Leu Leu Ile Phe Glu Asn Leu Ile Asp Leu
    1970                1975                1980                
 Lys Arg Arg Tyr Asn Phe Pro Val Glu Val Glu Val Pro Met Glu Arg
1985                1990                1995                2000
 Lys Lys Lys Tyr Ile Glu Ile Arg Lys Glu Ala Arg Glu Ala Ala Asn
                2005                2010                2015    
 Gly Asp Ser Asp Gly Pro Ser Tyr Met Ser Ser Leu Ser Tyr Leu Ala
            2020                2025                2030        
 Asp Ser Thr Leu Ser Glu Glu Met Ser Gln Phe Asp Phe Ser Thr Gly
        2035                2040                2045            
 Val Gln Ser Tyr Ser Tyr Ser Ser Gln Asp Pro Arg Pro Ala Thr Gly
    2050                2055                2060                
 Arg Phe Arg Arg Arg Glu Gln Arg Asp Pro Thr Val His Asp Asp Val
2065                2070                2075                2080
 Leu Glu Leu Glu Met Asp Glu Leu Asn Arg His Glu Cys Met Ala Pro
                2085                2090                2095    
 Leu Thr Ala Leu Val Lys His Met His Arg Ser Leu Gly Pro Pro Gln
            2100                2105                2110        
 Gly Glu Glu Asp Ser Val Pro Arg Asp Leu Pro Ser Trp Met Lys Phe
        2115                2120                2125            
 Leu His Gly Lys Leu Gly Asn Pro Ile Val Pro Leu Asn Ile Arg Leu
    2130                2135                2140                
 Phe Leu Ala Lys Leu Val Ile Asn Thr Glu Glu Val Phe Arg Pro Tyr
2145                2150                2155                2160
 Ala Lys His Trp Leu Ser Pro Leu Leu Gln Leu Ala Ala Ser Glu Asn
                2165                2170                2175    
 Asn Gly Gly Glu Gly Ile His Tyr Met Val Val Glu Ile Val Ala Thr
            2180                2185                2190        
 Ile Leu Ser Trp Thr Gly Leu Ala Thr Pro Thr Gly Val Pro Lys Asp
        2195                2200                2205            
 Glu Val Leu Ala Asn Arg Leu Leu Asn Phe Leu Met Lys His Val Phe
    2210                2215                2220                
 His Pro Lys Arg Ala Val Phe Arg His Asn Leu Glu Ile Ile Lys Thr
2225                2230                2235                2240
 Leu Val Glu Cys Trp Lys Asp Cys Leu Ser Ile Pro Tyr Arg Leu Ile
                2245                2250                2255    
 Phe Glu Lys Phe Ser Gly Lys Asp Pro Asn Ser Lys Asp Asn Ser Val
            2260                2265                2270        
 Gly Ile Gln Leu Leu Gly Ile Val Met Ala Asn Asp Leu Pro Pro Tyr
        2275                2280                2285            
 Asp Pro Gln Cys Gly Ile Gln Ser Ser Glu Tyr Phe Gln Ala Leu Val
    2290                2295                2300                
 Asn Asn Met Ser Phe Val Arg Tyr Lys Glu Val Tyr Ala Ala Ala Ala
2305                2310                2315                2320
 Glu Val Leu Gly Leu Ile Leu Arg Tyr Val Met Glu Arg Lys Asn Ile
                2325                2330                2335    
 Leu Glu Glu Ser Leu Cys Glu Leu Val Ala Lys Gln Leu Lys Gln His
            2340                2345                2350        
 Gln Asn Thr Met Glu Asp Lys Phe Ile Val Cys Leu Asn Lys Val Thr
        2355                2360                2365            
 Lys Ser Phe Pro Pro Leu Ala Asp Arg Phe Met Asn Ala Val Phe Phe
    2370                2375                2380                
 Leu Leu Pro Lys Phe His Gly Val Leu Lys Thr Leu Cys Leu Glu Val
2385                2390                2395                2400
 Val Leu Cys Arg Val Glu Gly Met Thr Glu Leu Tyr Phe Gln Leu Lys
                2405                2410                2415    
 Ser Lys Asp Phe Val Gln Val Met Arg His Arg Asp Asp Glu Arg Gln
            2420                2425                2430        
 Lys Val Cys Leu Asp Ile Ile Tyr Lys Met Met Pro Lys Leu Lys Pro
        2435                2440                2445            
 Val Glu Leu Arg Glu Leu Leu Asn Pro Val Val Glu Phe Val Ser His
    2450                2455                2460                
 Pro Ser Thr Thr Cys Arg Glu Gln Met Tyr Asn Ile Leu Met Trp Ile
2465                2470                2475                2480
 His Asp Asn Tyr Arg Asp Pro Glu Ser Glu Thr Asp Asn Asp Ser Gln
                2485                2490                2495    
 Glu Ile Phe Lys Leu Ala Lys Asp Val Leu Ile Gln Gly Leu Ile Asp
            2500                2505                2510        
 Glu Asn Pro Gly Leu Gln Leu Ile Ile Arg Asn Phe Trp Ser His Glu
        2515                2520                2525            
 Thr Arg Leu Pro Ser Asn Thr Leu Asp Arg Leu Leu Ala Leu Asn Ser
    2530                2535                2540                
 Leu Tyr Ser Pro Lys Ile Glu Val His Phe Leu Ser Leu Ala Thr Asn
2545                2550                2555                2560
 Phe Leu Leu Glu Met Thr Ser Met Ser Pro Asp Tyr Pro Asn Pro Met
                2565                2570                2575    
 Phe Glu His Pro Leu Ser Glu Cys Glu Phe Gln Glu Tyr Thr Ile Asp
            2580                2585                2590        
 Ser Asp Trp Arg Phe Arg Ser Thr Val Leu Thr Pro Met Phe Val Glu
        2595                2600                2605            
 Thr Gln Ala Ser Gln Gly Thr Leu Gln Thr Arg Thr Gln Glu Gly Ser
    2610                2615                2620                
 Leu Ser Ala Arg Trp Pro Val Ala Gly Gln Ile Arg Ala Thr Gln Gln
2625                2630                2635                2640
 Gln His Asp Phe Thr Leu Thr Gln Thr Ala Asp Gly Arg Ser Ser Phe
                2645                2650                2655    
 Asp Trp Leu Thr Gly Ser Ser Thr Asp Pro Leu Val Asp His Thr Ser
            2660                2665                2670        
 Pro Ser Ser Asp Ser Leu Leu Phe Ala His Lys Arg Ser Glu Arg Leu
        2675                2680                2685            
 Gln Arg Ala Pro Leu Lys Ser Val Gly Pro Asp Phe Gly Lys Lys Arg
    2690                2695                2700                
 Leu Gly Leu Pro Gly Asp Glu Val Asp Asn Lys Val Lys Gly Ala Ala
2705                2710                2715                2720
 Gly Arg Thr Asp Leu Leu Arg Leu Arg Arg Arg Phe Met Arg Asp Gln
                2725                2730                2735    
 Glu Lys Leu Ser Leu Met Tyr Ala Arg Lys Gly Val Ala Glu Gln Lys
            2740                2745                2750        
 Arg Glu Lys Glu Ile Lys Ser Glu Leu Lys Met Lys Gln Asp Ala Gln
        2755                2760                2765            
 Val Val Leu Tyr Arg Ser Tyr Arg His Gly Asp Leu Pro Asp Ile Gln
    2770                2775                2780                
 Ile Lys His Ser Ser Leu Ile Thr Pro Leu Gln Ala Val Ala Gln Arg
2785                2790                2795                2800
 Asp Pro Ile Ile Ala Lys Gln Leu Phe Ser Ser Leu Phe Ser Gly Ile
                2805                2810                2815    
 Leu Lys Glu Met Asp Lys Phe Lys Thr Leu Ser Glu Lys Asn Asn Ile
            2820                2825                2830        
 Thr Gln Lys Leu Leu Gln Asp Phe Asn Arg Phe Leu Asn Thr Thr Phe
        2835                2840                2845            
 Ser Phe Phe Pro Pro Phe Val Ser Cys Ile Gln Asp Ile Ser Cys Gln
    2850                2855                2860                
 His Ala Ala Leu Leu Ser Leu Asp Pro Ala Ala Val Ser Ala Gly Cys
2865                2870                2875                2880
 Leu Ala Ser Leu Gln Gln Pro Val Gly Ile Arg Leu Leu Glu Glu Ala
                2885                2890                2895    
 Leu Leu Arg Leu Leu Pro Ala Glu Leu Pro Ala Lys Arg Val Arg Gly
            2900                2905                2910        
 Lys Ala Arg Leu Pro Pro Asp Val Leu Arg Trp Val Glu Leu Ala Lys
        2915                2920                2925            
 Leu Tyr Arg Ser Ile Gly Glu Tyr Asp Val Leu Arg Gly Ile Phe Thr
    2930                2935                2940                
 Ser Glu Ile Gly Thr Lys Gln Ile Thr Gln Ser Ala Leu Leu Ala Glu
2945                2950                2955                2960
 Ala Arg Ser Asp Tyr Ser Glu Ala Ala Lys Gln Tyr Asp Glu Ala Leu
                2965                2970                2975    
 Asn Lys Gln Asp Trp Val Asp Gly Glu Pro Thr Glu Ala Glu Lys Asp
            2980                2985                2990        
 Phe Trp Glu Leu Ala Ser Leu Asp Cys Tyr Asn His Leu Ala Glu Trp
        2995                3000                3005            
 Lys Ser Leu Glu Tyr Cys Ser Thr Ala Ser Ile Asp Ser Glu Asn Pro
    3010                3015                3020                
 Pro Asp Leu Asn Lys Ile Trp Ser Glu Pro Phe Tyr Gln Glu Thr Tyr
3025                3030                3035                3040
 Leu Pro Tyr Met Ile Arg Ser Lys Leu Lys Leu Leu Leu Gln Gly Glu
                3045                3050                3055    
 Ala Asp Gln Ser Leu Leu Thr Phe Ile Asp Lys Ala Met His Gly Glu
            3060                3065                3070        
 Leu Gln Lys Ala Ile Leu Glu Leu His Tyr Ser Gln Glu Leu Ser Leu
        3075                3080                3085            
 Leu Tyr Leu Leu Gln Asp Asp Val Asp Arg Ala Lys Tyr Tyr Ile Gln
    3090                3095                3100                
 Asn Gly Ile Gln Ser Phe Met Gln Asn Tyr Ser Ser Ile Asp Val Leu
3105                3110                3115                3120
 Leu His Gln Ser Arg Leu Thr Lys Leu Gln Ser Val Gln Ala Leu Thr
                3125                3130                3135    
 Glu Ile Gln Glu Phe Ile Ser Phe Ile Ser Lys Gln Gly Asn Leu Ser
            3140                3145                3150        
 Ser Gln Val Pro Leu Lys Arg Leu Leu Asn Thr Trp Thr Asn Arg Tyr
        3155                3160                3165            
 Pro Asp Ala Lys Met Asp Pro Met Asn Ile Trp Asp Asp Ile Ile Thr
    3170                3175                3180                
 Asn Arg Cys Phe Phe Leu Ser Lys Ile Glu Glu Lys Leu Thr Pro Leu
3185                3190                3195                3200
 Pro Glu Asp Asn Ser Met Asn Val Asp Gln Asp Gly Asp Pro Ser Asp
                3205                3210                3215    
 Arg Met Glu Val Gln Glu Gln Glu Glu Asp Ile Ser Ser Leu Ile Arg
            3220                3225                3230        
 Ser Cys Lys Phe Ser Met Lys Met Lys Met Ile Asp Ser Ala Arg Lys
        3235                3240                3245            
 Gln Asn Asn Phe Ser Leu Ala Met Lys Leu Leu Lys Glu Leu His Lys
    3250                3255                3260                
 Glu Ser Lys Thr Arg Asp Asp Trp Leu Val Ser Trp Val Gln Ser Tyr
3265                3270                3275                3280
 Cys Arg Leu Ser His Cys Arg Ser Arg Ser Gln Gly Cys Ser Glu Gln
                3285                3290                3295    
 Val Leu Thr Val Leu Lys Thr Val Ser Leu Leu Asp Glu Asn Asn Val
            3300                3305                3310        
 Ser Ser Tyr Leu Ser Lys Asn Ile Leu Ala Phe Arg Asp Gln Asn Ile
        3315                3320                3325            
 Leu Leu Gly Thr Thr Tyr Arg Ile Ile Ala Asn Ala Leu Ser Ser Glu
    3330                3335                3340                
 Pro Ala Cys Leu Ala Glu Ile Glu Glu Asp Lys Ala Arg Arg Ile Leu
3345                3350                3355                3360
 Glu Leu Ser Gly Ser Ser Ser Glu Asp Ser Glu Lys Val Ile Ala Gly
                3365                3370                3375    
 Leu Tyr Gln Arg Ala Phe Gln His Leu Ser Glu Ala Val Gln Ala Ala
            3380                3385                3390        
 Glu Glu Glu Ala Gln Pro Pro Ser Trp Ser Cys Gly Pro Ala Ala Gly
        3395                3400                3405            
 Val Ile Asp Ala Tyr Met Thr Leu Ala Asp Phe Cys Asp Gln Gln Leu
    3410                3415                3420                
 Arg Lys Glu Glu Glu Asn Ala Ser Val Ile Asp Ser Ala Glu Leu Gln
3425                3430                3435                3440
 Ala Tyr Pro Ala Leu Val Val Glu Lys Met Leu Lys Ala Leu Lys Leu
                3445                3450                3455    
 Asn Ser Asn Glu Ala Arg Leu Lys Phe Pro Arg Leu Leu Gln Ile Ile
            3460                3465                3470        
 Glu Arg Tyr Pro Glu Glu Thr Leu Ser Leu Met Thr Lys Glu Ile Ser
        3475                3480                3485            
 Ser Val Pro Cys Trp Gln Phe Ile Ser Trp Ile Ser His Met Val Ala
    3490                3495                3500                
 Leu Leu Asp Lys Asp Gln Ala Val Ala Val Gln His Ser Val Glu Glu
3505                3510                3515                3520
 Ile Thr Asp Asn Tyr Pro Gln Ala Ile Val Tyr Pro Phe Ile Ile Ser
                3525                3530                3535    
 Ser Glu Ser Tyr Ser Phe Lys Asp Thr Ser Thr Gly His Lys Asn Lys
            3540                3545                3550        
 Glu Phe Val Ala Arg Ile Lys Ser Lys Leu Asp Gln Gly Gly Val Ile
        3555                3560                3565            
 Gln Asp Phe Ile Asn Ala Leu Asp Gln Leu Ser Asn Pro Glu Leu Leu
    3570                3575                3580                
 Phe Lys Asp Trp Ser Asn Asp Val Arg Ala Glu Leu Ala Lys Thr Pro
3585                3590                3595                3600
 Val Asn Lys Lys Asn Ile Glu Lys Met Tyr Glu Arg Met Tyr Ala Ala
                3605                3610                3615    
 Leu Gly Asp Pro Lys Ala Pro Gly Leu Gly Ala Phe Arg Arg Lys Phe
            3620                3625                3630        
 Ile Gln Thr Phe Gly Lys Glu Phe Asp Lys His Phe Gly Lys Gly Gly
        3635                3640                3645            
 Ser Lys Leu Leu Arg Met Lys Leu Ser Asp Phe Asn Asp Ile Thr Asn
    3650                3655                3660                
 Met Leu Leu Leu Lys Met Asn Lys Asp Ser Lys Pro Pro Gly Asn Leu
3665                3670                3675                3680
 Lys Glu Cys Ser Pro Trp Met Ser Asp Phe Lys Val Glu Phe Leu Arg
                3685                3690                3695    
 Asn Glu Leu Glu Ile Pro Gly Gln Tyr Asp Gly Arg Gly Lys Pro Leu
            3700                3705                3710        
 Pro Glu Tyr His Val Arg Ile Ala Gly Phe Asp Glu Arg Val Thr Val
        3715                3720                3725            
 Met Ala Ser Leu Arg Arg Pro Lys Arg Ile Ile Ile Arg Gly His Asp
    3730                3735                3740                
 Glu Arg Glu His Pro Phe Leu Val Lys Gly Gly Glu Asp Leu Arg Gln
3745                3750                3755                3760
 Asp Gln Arg Val Glu Gln Leu Phe Gln Val Met Asn Gly Ile Leu Ala
                3765                3770                3775    
 Gln Asp Ser Ala Cys Ser Gln Arg Ala Leu Gln Leu Arg Thr Tyr Ser
            3780                3785                3790        
 Val Val Pro Met Thr Ser Arg Leu Gly Leu Ile Glu Trp Leu Glu Asn
        3795                3800                3805            
 Thr Val Thr Leu Lys Asp Leu Leu Leu Asn Thr Met Ser Gln Glu Glu
    3810                3815                3820                
 Lys Ala Ala Tyr Leu Ser Asp Pro Arg Ala Pro Pro Cys Glu Tyr Lys
3825                3830                3835                3840
 Asp Trp Leu Thr Lys Met Ser Gly Lys His Asp Val Gly Ala Tyr Met
                3845                3850                3855    
 Leu Met Tyr Lys Gly Ala Asn Arg Thr Glu Thr Val Thr Ser Phe Arg
            3860                3865                3870        
 Lys Arg Glu Ser Lys Val Pro Ala Asp Leu Leu Lys Arg Ala Phe Val
        3875                3880                3885            
 Arg Met Ser Thr Ser Pro Glu Ala Phe Leu Ala Leu Arg Ser His Phe
    3890                3895                3900                
 Ala Ser Ser His Ala Leu Ile Cys Ile Ser His Trp Ile Leu Gly Ile
3905                3910                3915                3920
 Gly Asp Arg His Leu Asn Asn Phe Met Val Ala Met Glu Thr Gly Gly
                3925                3930                3935    
 Val Ile Gly Ile Asp Phe Gly His Ala Phe Gly Ser Ala Thr Gln Phe
            3940                3945                3950        
 Leu Pro Val Pro Glu Leu Met Pro Phe Arg Leu Thr Arg Gln Phe Ile
        3955                3960                3965            
 Asn Leu Met Leu Pro Met Lys Glu Thr Gly Leu Met Tyr Ser Ile Met
    3970                3975                3980                
 Val His Ala Leu Arg Ala Phe Arg Ser Asp Pro Gly Leu Leu Thr Asn
3985                3990                3995                4000
 Thr Met Asp Val Phe Val Lys Glu Pro Ser Phe Asp Trp Lys Asn Phe
                4005                4010                4015    
 Glu Gln Lys Met Leu Lys Lys Gly Gly Ser Trp Ile Gln Glu Ile Asn
            4020                4025                4030        
 Val Ala Glu Lys Asn Trp Tyr Pro Arg Gln Lys Ile Cys Tyr Ala Lys
        4035                4040                4045            
 Arg Lys Leu Ala Gly Ala Asn Pro Ala Val Ile Thr Cys Asp Glu Leu
    4050                4055                4060                
 Leu Leu Gly His Glu Lys Ala Pro Ala Phe Arg Asp Tyr Val Ala Val
4065                4070                4075                4080
 Ala Arg Gly Ser Lys Asp His Asn Ile Arg Ala Gln Glu Pro Glu Ser
                4085                4090                4095    
 Gly Leu Ser Glu Glu Thr Gln Val Lys Cys Leu Met Asp Gln Ala Thr
            4100                4105                4110        
 Asp Pro Asn Ile Leu Gly Arg Thr Trp Glu Gly Trp Glu Pro Trp Met
        4115                4120                4125            





      <210> 417
      <211> 25
      <212> PRT
      <213> Homo sapiens


      <400> 417
 Met Arg Ala Lys Trp Arg Lys Lys Arg Met Arg Arg Leu Lys Arg Lys
   1               5                  10                  15    
 Arg Arg Lys Met Arg Gln Arg Ser Lys
              20                  25



      <210> 418
      <211> 426
      <212> PRT
      <213> Homo sapiens


      <400> 418
 Met Trp Arg Gly Leu Trp Thr Leu Ala Ala Gln Ala Ala Arg Gly Pro
   1               5                  10                  15    
 Arg Arg Leu Cys Thr Arg Arg Ser Ser Gly Ala Pro Ala Pro Gly Ser
              20                  25                  30        
 Gly Ala Thr Ile Phe Ala Leu Ser Ser Gly Gln Gly Arg Cys Gly Ile
          35                  40                  45            
 Ala Val Ile Arg Thr Ser Gly Pro Ala Ser Gly His Ala Leu Arg Ile
      50                  55                  60                
 Leu Thr Ala Pro Arg Asp Leu Pro Leu Ala Arg His Ala Ser Leu Arg
  65                  70                  75                  80
 Leu Leu Ser Asp Pro Arg Ser Gly Glu Pro Leu Asp Arg Ala Leu Val
                  85                  90                  95    
 Leu Trp Phe Pro Gly Pro Gln Ser Phe Thr Gly Glu Asp Cys Val Glu
             100                 105                 110        
 Phe His Val His Gly Gly Pro Ala Val Val Ser Gly Val Leu Gln Ala
         115                 120                 125            
 Leu Gly Glu Leu Gln Arg Trp Ala Leu Ala His Val Glu Ala Tyr Ile
     130                 135                 140                
 Asp Phe Gly Glu Asp Asp Asn Leu Glu Glu Gly Pro Thr Ser Lys Tyr
 145                 150                 155                 160
 Gly His Cys Arg Trp Pro Leu Gly Ala His Leu Arg Asp Ala Arg Arg
                 165                 170                 175    
 Gly Gln Arg Leu Arg Ser Gly Val His Val Val Val Thr Gly Pro Pro
             180                 185                 190        
 Asn Ala Gly Lys Ser Ser Leu Val Asn Leu Leu Ser Arg Lys Pro Val
         195                 200                 205            
 Ser Ile Val Ser Pro Glu Pro Gly Thr Thr Arg Asp Val Leu Glu Thr
     210                 215                 220                
 Pro Val Asp Leu Ala Gly Phe Pro Val Leu Leu Ser Asp Thr Ala Gly
 225                 230                 235                 240
 Leu Arg Glu Gly Val Gly Pro Val Glu Gln Glu Gly Val Arg Arg Ala
                 245                 250                 255    
 Arg Glu Arg Leu Glu Gln Ala Asp Leu Ile Leu Ala Met Leu Asp Ala
             260                 265                 270        
 Ser Asp Leu Ala Ser Pro Ser Ser Cys Asn Phe Leu Ala Thr Val Val
         275                 280                 285            
 Ala Ser Val Gly Ala Gln Ser Pro Ser Asp Ser Ser Gln Arg Leu Leu
     290                 295                 300                
 Leu Val Leu Asn Lys Ser Asp Leu Leu Ser Pro Glu Gly Pro Gly Pro
 305                 310                 315                 320
 Gly Pro Asp Leu Pro Pro His Leu Leu Leu Ser Cys Leu Thr Gly Glu
                 325                 330                 335    
 Gly Leu Asp Gly Leu Leu Glu Ala Leu Arg Lys Glu Leu Ala Ala Val
             340                 345                 350        
 Cys Gly Asp Pro Ser Thr Asp Pro Pro Leu Leu Thr Arg Ala Arg His
         355                 360                 365            
 Gln His His Leu Gln Gly Cys Leu Asp Ala Leu Gly His Tyr Lys Gln
     370                 375                 380                
 Ser Lys Asp Leu Ala Leu Ala Ala Glu Ala Leu Arg Val Ala Arg Gly
 385                 390                 395                 400
 His Leu Thr Arg Leu Thr Gly Gly Gly Gly Thr Glu Glu Ile Leu Asp
                 405                 410                 415    
 Ile Ile Phe Gln Asp Phe Cys Val Gly Lys
             420                 425    



      <210> 419
      <211> 216
      <212> PRT
      <213> Homo sapiens


      <400> 419
 Met Val Phe Arg Arg Phe Val Glu Val Gly Arg Val Ala Tyr Val Ser
   1               5                  10                  15    
 Phe Gly Pro His Ala Gly Lys Leu Val Ala Ile Val Asp Val Ile Asp
              20                  25                  30        
 Gln Asn Arg Ala Leu Val Asp Gly Pro Cys Thr Gln Val Arg Arg Gln
          35                  40                  45            
 Ala Met Pro Phe Lys Cys Met Gln Leu Thr Asp Phe Ile Leu Lys Phe
      50                  55                  60                
 Pro His Ser Ala His Gln Lys Tyr Val Arg Gln Ala Trp Gln Lys Ala
  65                  70                  75                  80
 Asp Ile Asn Thr Lys Trp Ala Ala Thr Arg Trp Ala Lys Lys Ile Glu
                  85                  90                  95    
 Ala Arg Glu Arg Lys Ala Lys Met Thr Asp Phe Asp Arg Phe Lys Val
             100                 105                 110        
 Met Lys Ala Lys Lys Met Arg Asn Arg Ile Ile Lys Asn Glu Val Lys
         115                 120                 125            
 Lys Leu Gln Lys Ala Ala Leu Leu Lys Ala Ser Pro Lys Lys Ala Pro
     130                 135                 140                
 Gly Thr Lys Gly Thr Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala
 145                 150                 155                 160
 Lys Val Pro Ala Lys Lys Ile Thr Ala Ala Ser Lys Lys Ala Pro Ala
                 165                 170                 175    
 Gln Lys Val Pro Ala Gln Lys Ala Thr Gly Gln Lys Ala Ala Pro Ala
             180                 185                 190        
 Pro Lys Ala Gln Lys Gly Gln Lys Ala Pro Ala Gln Lys Ala Pro Ala
         195                 200                 205            
 Pro Lys Ala Ser Gly Lys Lys Ala
     210                 215    



      <210> 420
      <211> 500
      <212> PRT
      <213> Homo sapiens


      <400> 420
 Met Met Ser Ile Asp Gly Glu Gln Trp Ser Phe Gly Ile Leu Leu Ala
   1               5                  10                  15    
 Val His Ile Asp Ala Leu Leu Cys His Thr Val Pro Glu Pro Arg Ser
              20                  25                  30        
 Pro Phe Ala Leu Gly Ala Asn Lys Asp Ser Leu Ser Ala Phe Glu Tyr
          35                  40                  45            
 Pro Gly Pro Lys Arg Lys Leu Tyr Ser Ala Val Pro Gly Arg Leu Phe
      50                  55                  60                
 Val Ala Val Lys Pro Tyr Gln Pro Gln Val Asp Gly Glu Ile Pro Leu
  65                  70                  75                  80
 His Arg Gly Asp Arg Val Lys Gly Gln Cys Leu Leu Val Val Leu Arg
                  85                  90                  95    
 Ser Trp Ser Glu His Thr Gly Thr Gln Gln His Leu Leu Lys His Asp
             100                 105                 110        
 Gln Thr Gly Thr Arg Pro Ser Gln Glu Arg Gly Ala Cys Gly Glu Leu
         115                 120                 125            
 Gly Leu Ser Pro Arg Glu Asn Arg Asn Asp Arg Ala Arg Phe Gln Asn
     130                 135                 140                
 Ser His Phe Lys Gly Ser Met Ala Lys Asp Cys Cys Ser Glu Lys Arg
 145                 150                 155                 160
 Phe Glu Trp Ala Ala Gln Ala Ile Cys Thr Gln Leu Ala Arg Ser Pro
                 165                 170                 175    
 Phe Leu Leu Pro Val Ala Pro Leu Phe Leu Pro Ala Glu Leu Ser Val
             180                 185                 190        
 Pro Pro Pro His Arg Pro Arg Arg Gly Pro Ala Pro Ser Lys Pro Glu
         195                 200                 205            
 Lys Asn Pro Glu Pro Leu Asp Gly Ser His Ala Ala Ala Leu Thr Ala
     210                 215                 220                
 Gly Pro Glu Arg Thr Leu Ser Gly His Arg Pro Lys Ser Thr Leu Gly
 225                 230                 235                 240
 Val Ile Ala Gly Asp Glu Leu Thr Pro Glu Pro Gln Val Asp Gly Ser
                 245                 250                 255    
 His Ser Pro Ala Ile Cys Thr Gln Ala Arg Pro Phe Thr Leu Gln Ala
             260                 265                 270        
 Thr Glu Thr Gln Lys Pro Ala Thr Asp Gln Gly Ser Cys Val Glu Gly
         275                 280                 285            
 Leu Gln Arg Pro Trp Arg Leu Val Pro Ala Thr Phe Leu Leu Asn Ala
     290                 295                 300                
 Asp Glu Val Leu Phe Gln Met Asp Phe Ile Leu Glu Glu Gly Glu Ile
 305                 310                 315                 320
 Gly Gly Glu Glu Leu Pro Gly Trp Ser His Pro Ser Ser Cys Leu Lys
                 325                 330                 335    
 His Lys Gly Glu Gly Leu Gly Ala Arg Asn Thr Val Gly Thr Pro Leu
             340                 345                 350        
 Gly Thr Ser Leu Ser Ser Val Ser Pro Glu Lys Ser Arg Glu Leu Ser
         355                 360                 365            
 Val Pro Leu Phe Pro Ser Leu Phe Asn Gly Asp Ile Asn Gly Ala Thr
     370                 375                 380                
 Ser Gln Glu Ser His Lys Asp Lys Asp Arg Gly Arg Pro Val Glu Asn
 385                 390                 395                 400
 Arg Gly Glu Gly Thr Glu Glu Arg Ala Ser Glu Pro Pro Thr Gly Ser
                 405                 410                 415    
 Leu Ser Leu Val Gly Glu Leu Lys Gly Ala Gly Gly Val Thr Pro Arg
             420                 425                 430        
 Asp Thr Thr His Arg Phe Ser Asp Pro Glu Leu Ser Phe Arg Ala Lys
         435                 440                 445            
 Asn Met Ala Ile Leu Gly Gly Ser Gly Glu Glu Leu Trp Arg Val Lys
     450                 455                 460                
 Ala Pro His Arg Leu Gly Ile Trp Cys Gln Thr Ala Asp Ala Arg Thr
 465                 470                 475                 480
 Thr Gln Lys Glu Pro Leu Gln Leu Pro Asn Ala Trp Val Ser Gln Asp
                 485                 490                 495    
 Thr Phe Lys His
             500



      <210> 421
      <211> 641
      <212> PRT
      <213> Homo sapiens


      <400> 421
 Met Leu Arg Glu Glu Ala Thr Lys Lys Ser Lys Glu Lys Glu Pro Gly
   1               5                  10                  15    
 Met Ala Leu Pro Gln Gly Arg Leu Thr Phe Arg Asp Val Ala Ile Glu
              20                  25                  30        
 Phe Ser Leu Glu Glu Trp Lys Cys Leu Asn Pro Ala Gln Arg Ala Leu
          35                  40                  45            
 Tyr Arg Ala Val Met Leu Glu Asn Tyr Arg Asn Leu Glu Phe Val Asp
      50                  55                  60                
 Ser Ser Leu Lys Ser Met Thr Glu Phe Ser Ser Thr Gly His Gly Asn
  65                  70                  75                  80
 Thr Gly Glu Val Ile His Thr Gly Thr Leu Gln Arg His Lys Ser His
                  85                  90                  95    
 His Ile Gly Asp Phe Cys Phe Pro Glu Ile Lys Lys Asp Ile His Asp
             100                 105                 110        
 Phe Glu Phe Gln Trp Gln Glu Ile Lys Arg Asn Gly His Glu Ala Pro
         115                 120                 125            
 Met Thr Lys Ile Lys Lys Leu Thr Gly Ser Thr Asp Arg Arg Asp Gln
     130                 135                 140                
 Arg His Ala Gly Asn Lys Pro Ile Lys Asp Gln Leu Gly Ser Ser Phe
 145                 150                 155                 160
 Tyr Ser His Leu Pro Glu Leu His Glu Phe Gln Thr Glu Gly Lys Ile
                 165                 170                 175    
 Asp Asn Gln Val Glu Lys Ser Ile Asn Asn Ala Ser Leu Val Ser Thr
             180                 185                 190        
 Ser Gln Arg Ile Ser Cys Arg Leu Lys Thr His Ile Ser Asn Arg Tyr
         195                 200                 205            
 Gly Lys Asn Phe Leu His Ser Ser Leu Leu Thr Gln Ile Gln Glu Glu
     210                 215                 220                
 His Val Arg Glu Lys Pro Phe Gln Cys Asn Glu Cys Gly Lys Ala Phe
 225                 230                 235                 240
 Asn Tyr Ser Ser His Leu Arg Arg His His Val Thr His Ser Gly Glu
                 245                 250                 255    
 Lys Gln Tyr Lys Cys Asp Val Cys Gly Lys Val Phe His Gln Lys Gln
             260                 265                 270        
 Tyr Leu Ala Trp His His Arg Val His Thr Gly Glu Lys Pro Tyr Lys
         275                 280                 285            
 Cys Asn Glu Cys Ser Lys Thr Phe Gly His Lys Ser Ser Leu Thr Arg
     290                 295                 300                
 His His Arg Leu His Thr Gly Glu Lys Pro Tyr Lys Cys Asn Glu Cys
 305                 310                 315                 320
 Gly Lys Thr Phe Ser Gln Thr Ser Ser Leu Val Gly His Arg Arg Arg
                 325                 330                 335    
 His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Gly Cys Asp Lys Val Tyr
             340                 345                 350        
 Ser Cys Arg Ser Gln Leu Glu Thr His Arg Arg Ile His Thr Gly Glu
         355                 360                 365            
 Lys Pro Tyr Lys Cys Lys Val Cys Asp Lys Ala Phe Arg His Asn Ser
     370                 375                 380                
 Cys Leu Ser Arg His Asn Arg Val His Thr Glu Glu Lys Pro Tyr Thr
 385                 390                 395                 400
 Cys Asn Glu Cys Gly Lys Val Phe Gln Arg Asp Ser Tyr Leu Ala Gln
                 405                 410                 415    
 His Gln Arg Val His Thr Gly Glu Lys Pro Tyr Thr Cys Asn Glu Cys
             420                 425                 430        
 Gly Lys Val Phe Asn Gln Lys Ala His Leu Ala Cys His Tyr Arg Leu
         435                 440                 445            
 His Thr Gly Glu Lys Pro Tyr Lys Cys Asn Glu Cys Gly Lys Thr Phe
     450                 455                 460                
 Ser Gln Lys Ser Ser Leu Val Gly His Arg Arg Leu His Thr Gly Glu
 465                 470                 475                 480
 Lys Pro Tyr Asn Cys His Glu Cys Gly Lys Thr Phe Ala Arg Asn Ser
                 485                 490                 495    
 Ser Leu Leu Ile His Lys Ala Ile His Thr Gly Glu Lys Pro Tyr Lys
             500                 505                 510        
 Cys Asn Glu Cys Gly Lys Val Phe Asn Gln Gln Ser Asn Leu Ala Gln
         515                 520                 525            
 His Gln Arg Val His Thr Gly Glu Lys Pro Tyr Arg Cys Asn Glu Cys
     530                 535                 540                
 Gly Lys Thr Phe Ser His Met Ser Ser Phe Val Tyr His Tyr Arg Leu
 545                 550                 555                 560
 His Ser Gly Glu Lys Pro Tyr Lys Cys Asn Glu Cys Gly Lys Thr Phe
                 565                 570                 575    
 Ser His Met Ser Ser Phe Val Cys His His Arg Leu His Thr Gly Glu
             580                 585                 590        
 Asn Pro Tyr Lys Cys Asn Glu Cys Gly Lys Ala Phe Ser Gly Gln Ser
         595                 600                 605            
 Ser Leu Ile His His Gln Ala Ile His Gly Ile Gly Lys Leu Tyr Lys
     610                 615                 620                
 Cys Asn Asp Ser His Lys Val Leu Ser Asn Ala Thr Ser Ile Ala Asn
 625                 630                 635                 640
 His
    



      <210> 422
      <211> 161
      <212> PRT
      <213> Homo sapiens


      <400> 422
 Met Gly Cys Cys Tyr Ser Ser Glu Asn Glu Asp Ser Asp Gln Asp Arg
   1               5                  10                  15    
 Glu Glu Arg Lys Leu Leu Leu Asp Pro Ser Ser Pro Pro Thr Lys Ala
              20                  25                  30        
 Leu Asn Gly Ala Glu Pro Asn Tyr His Ser Leu Pro Ser Ala Arg Thr
          35                  40                  45            
 Asp Glu Gln Ala Leu Leu Ser Ser Ile Leu Ala Lys Thr Ala Ser Asn
      50                  55                  60                
 Ile Ile Asp Val Ser Ala Ala Asp Ser Gln Gly Met Glu Gln His Glu
  65                  70                  75                  80
 Tyr Met Asp Arg Ala Arg Gln Tyr Ser Thr Arg Leu Ala Val Leu Ser
                  85                  90                  95    
 Ser Ser Leu Thr His Trp Lys Lys Leu Pro Pro Leu Pro Ser Leu Thr
             100                 105                 110        
 Ser Gln Pro His Gln Val Leu Ala Ser Glu Pro Ile Pro Phe Ser Asp
         115                 120                 125            
 Leu Gln Gln Val Ser Arg Ile Ala Ala Tyr Ala Tyr Ser Ala Leu Ser
     130                 135                 140                
 Gln Ile Arg Val Asp Ala Lys Glu Glu Leu Val Val Gln Phe Gly Ile
 145                 150                 155                 160
 Pro
    



      <210> 423
      <211> 460
      <212> PRT
      <213> Homo sapiens


      <400> 423
 Met Ala Ala Ala Ala Ala Arg Val Val Leu Ser Ser Ala Ala Arg Arg
   1               5                  10                  15    
 Arg Leu Trp Gly Phe Ser Glu Ser Leu Leu Ile Arg Gly Ala Ala Gly
              20                  25                  30        
 Arg Ser Leu Tyr Phe Gly Glu Asn Arg Leu Arg Ser Thr Gln Ala Ala
          35                  40                  45            
 Thr Gln Val Val Leu Asn Val Pro Glu Thr Arg Val Thr Cys Leu Glu
      50                  55                  60                
 Ser Gly Leu Arg Val Ala Ser Glu Asp Ser Gly Leu Ser Thr Cys Thr
  65                  70                  75                  80
 Gly Thr Lys Lys Arg Ser Gln Leu Asp Leu Glu Leu Glu Ile Glu Asn
                  85                  90                  95    
 Met Gly Ala His Leu Asn Ala Tyr Thr Ser Arg Glu Gln Thr Val Tyr
             100                 105                 110        
 Tyr Ala Lys Ala Phe Ser Lys Asp Leu Pro Arg Ala Val Glu Ile Leu
         115                 120                 125            
 Ala Asp Ile Ile Gln Asn Ser Thr Leu Gly Glu Ala Glu Ile Glu Arg
     130                 135                 140                
 Glu Arg Gly Val Ile Leu Arg Glu Ile Gln Glu Val Glu Thr Asn Leu
 145                 150                 155                 160
 Gln Glu Val Val Phe Asp Tyr Leu His Ala Thr Ala Tyr Gln Asn Thr
                 165                 170                 175    
 Ala Leu Gly Arg Thr Ile Leu Gly Pro Thr Glu Asn Ile Lys Ser Ile
             180                 185                 190        
 Ser Arg Lys Asp Leu Val Asp Tyr Ile Thr Thr His Tyr Lys Gly Pro
         195                 200                 205            
 Arg Ile Val Leu Ala Ala Ala Gly Gly Val Ser His Asp Glu Leu Leu
     210                 215                 220                
 Asp Leu Ala Lys Phe His Phe Gly Asp Ser Leu Cys Thr His Lys Gly
 225                 230                 235                 240
 Glu Ile Pro Ala Leu Pro Pro Cys Lys Phe Thr Gly Ser Glu Ile Arg
                 245                 250                 255    
 Val Arg Asp Asp Lys Met Pro Leu Ala His Leu Ala Ile Ala Ile Ala
             260                 265                 270        
 Ala Val Gly Trp Ala His Pro Asp Thr Ile Cys Leu Met Val Ala Asn
         275                 280                 285            
 Thr Leu Ile Gly Asn Trp Asp Arg Ser Phe Gly Gly Gly Met Asn Leu
     290                 295                 300                
 Ser Ser Lys Leu Ala Gln Leu Thr Cys His Gly Asn Leu Cys His Ser
 305                 310                 315                 320
 Phe Gln Ser Phe Asn Thr Ser Tyr Thr Asp Thr Gly Leu Trp Gly Leu
                 325                 330                 335    
 Tyr Met Val Cys Glu Ser Ser Thr Val Ala Asp Met Leu His Val Val
             340                 345                 350        
 Gln Lys Glu Trp Met Arg Leu Cys Thr Ser Val Thr Glu Ser Glu Val
         355                 360                 365            
 Ala Arg Ala Arg Asn Leu Leu Lys Thr Asn Met Leu Leu Gln Leu Asp
     370                 375                 380                
 Gly Ser Thr Pro Ile Cys Glu Asp Ile Gly Arg Gln Met Leu Cys Tyr
 385                 390                 395                 400
 Asn Arg Arg Ile Pro Ile Pro Glu Leu Glu Ala Arg Ile Asp Ala Val
                 405                 410                 415    
 Asn Ala Glu Thr Ile Arg Glu Val Cys Thr Lys Tyr Ile Tyr Asn Arg
             420                 425                 430        
 Ser Pro Ala Ile Ala Ala Val Gly Pro Ile Lys Gln Leu Pro Asp Phe
         435                 440                 445            
 Lys Gln Ile Arg Ser Asn Met Cys Trp Leu Arg Asp
     450                 455                 460



      <210> 424
      <211> 97
      <212> PRT
      <213> Homo sapiens


      <400> 424
 Met Val Gln Ile Asp Phe Phe Phe Phe Leu Arg Gln Ser Leu Ala Leu
   1               5                  10                  15    
 Ser Pro Arg Leu Glu Cys Ser Gly Pro Val Ser Ala His Cys Asp Leu
              20                  25                  30        
 Arg Leu Pro Asp Ser Ser Asp Ser Pro Ala Leu Ala Ser Lys Val Ala
          35                  40                  45            
 Gly Thr Thr Gly Val Arg His His Ser Arg Pro Ile Ser Val Phe Leu
      50                  55                  60                
 Ala Lys Thr Gly Val Ser Pro Tyr Trp Pro Gly Trp Ser Arg Thr His
  65                  70                  75                  80
 Asp Leu Ala Ile Arg Pro Pro Arg Pro Pro Lys Val Leu Gly Pro Gln
                  85                  90                  95    
 Ala
    



      <210> 425
      <211> 58
      <212> PRT
      <213> Homo sapiens


      <400> 425
 Met Leu Pro Gln Leu Leu Ala Ser Arg Asn His Pro Ile Leu Ala Phe
   1               5                  10                  15    
 Gln Ser Asp Gly Ile Thr Gly Met Ser His Cys Ala Gln Ile Ala Tyr
              20                  25                  30        
 Ser Ser Leu Leu Ser Ser Phe Leu Leu Cys Lys Met Lys Asp Asn Ile
          35                  40                  45            
 Asn Ser Thr Cys Leu Ala Tyr Phe Thr Ser
      50                  55            



      <210> 426
      <211> 288
      <212> PRT
      <213> Homo sapiens


      <400> 426
 Met Ser Trp Ser Leu His Pro Arg Asn Leu Ile Leu Tyr Phe Tyr Ala
   1               5                  10                  15    
 Leu Leu Phe Leu Ser Ser Thr Cys Val Ala Tyr Val Ala Thr Arg Asp
              20                  25                  30        
 Asn Cys Cys Ile Leu Asp Glu Arg Phe Gly Ser Tyr Cys Pro Thr Thr
          35                  40                  45            
 Cys Gly Ile Ala Asp Phe Leu Ser Thr Tyr Gln Thr Lys Val Asp Lys
      50                  55                  60                
 Asp Leu Gln Ser Leu Glu Asp Ile Leu His Gln Val Glu Asn Lys Thr
  65                  70                  75                  80
 Ser Glu Val Lys Gln Leu Ile Lys Ala Ile Gln Leu Thr Tyr Asn Leu
                  85                  90                  95    
 Asp Glu Ser Ser Lys Pro Asn Met Ile Asp Ala Ala Thr Leu Lys Ser
             100                 105                 110        
 Arg Lys Met Leu Glu Glu Ile Met Lys Tyr Glu Ala Ser Ile Leu Thr
         115                 120                 125            
 His Asp Ser Ser Ile Arg Tyr Leu Gln Glu Ile Tyr Asn Ser Asn Asn
     130                 135                 140                
 Gln Lys Ile Val Asn Leu Lys Glu Lys Val Ala Gln Leu Glu Ala Gln
 145                 150                 155                 160
 Cys Gln Glu Pro Cys Lys Asp Thr Val Gln Ile His Asp Ile Thr Gly
                 165                 170                 175    
 Lys Asp Cys Gln Asp Ile Ala Asn Lys Gly Ala Lys Gln Ser Gly Leu
             180                 185                 190        
 Tyr Phe Ile Lys Pro Leu Lys Ala Asn Gln Gln Phe Leu Val Tyr Cys
         195                 200                 205            
 Glu Ile Asp Gly Ser Gly Asn Gly Trp Thr Val Phe Gln Lys Arg Leu
     210                 215                 220                
 Asp Gly Ser Val Asp Phe Lys Lys Asn Trp Ile Gln Tyr Lys Glu Gly
 225                 230                 235                 240
 Phe Gly His Leu Ser Pro Thr Gly Thr Thr Glu Phe Trp Leu Gly Asn
                 245                 250                 255    
 Glu Lys Ile His Leu Ile Ser Thr Gln Ser Ala Ile Pro Tyr Ala Leu
             260                 265                 270        
 Arg Val Gly Leu Gly Arg Leu Glu Trp Gln Asn Gln Tyr Leu Gly Gln
         275                 280                 285            





      <210> 427
      <211> 411
      <212> PRT
      <213> Homo sapiens


      <400> 427
 Met Lys Pro Ile Ala Thr Val Gly Glu Ser Tyr Gln Tyr Pro Pro Val
   1               5                  10                  15    
 Asn Trp Ala Ala Leu Leu Ser Pro Leu Met Arg Leu Asn Phe Gly Glu
              20                  25                  30        
 Glu Ile Gln Gln Leu Cys Leu Glu Ile Met Val Thr Gln Ala Gln Ser
          35                  40                  45            
 Ser Gln Asn Ala Ala Ala Leu Leu Gly Leu Trp Val Thr Pro Pro Leu
      50                  55                  60                
 Ile His Ser Leu Ser Leu Asn Thr Lys Arg Tyr Leu Leu Ile Ser Ala
  65                  70                  75                  80
 Pro Leu Trp Ile Lys His Ile Ser Asp Glu Gln Ile Leu Gly Phe Val
                  85                  90                  95    
 Glu Asn Leu Met Val Ala Val Phe Lys Ala Ala Ser Pro Leu Gly Ser
             100                 105                 110        
 Pro Glu Leu Cys Pro Ser Ala Leu His Gly Leu Ser Gln Ala Met Lys
         115                 120                 125            
 Leu Pro Ser Pro Ala His His Leu Trp Ser Leu Leu Ser Glu Ala Thr
     130                 135                 140                
 Gly Lys Ile Phe Asp Leu Leu Pro Asn Lys Ile Arg Arg Lys Asp Leu
 145                 150                 155                 160
 Glu Leu Tyr Ile Ser Ile Ala Lys Cys Leu Leu Glu Met Thr Asp Asp
                 165                 170                 175    
 Asp Ala Asn Arg Ile Ala Gln Val Thr Lys Ser Asn Ile Glu Lys Ala
             180                 185                 190        
 Ala Phe Val Lys Leu Tyr Leu Val Ser Gln Gly Arg Phe Pro Leu Val
         195                 200                 205            
 Asn Leu Thr Asp Met Leu Ser Val Ala Val Gln His Arg Glu Lys Glu
     210                 215                 220                
 Val Leu Ala Trp Met Ile Leu His Ser Leu Tyr Gln Ala Arg Ile Val
 225                 230                 235                 240
 Ser His Ala Asn Thr Gly Val Leu Lys Arg Met Glu Trp Leu Leu Glu
                 245                 250                 255    
 Leu Met Gly Tyr Ile Arg Asn Val Ala Tyr Gln Ser Thr Ser Phe His
             260                 265                 270        
 Asn Thr Ala Leu Asp Glu Ala Leu Asp Phe Phe Leu Leu Ile Phe Ala
         275                 280                 285            
 Thr Ala Val Val Ala Trp Ala Asp His Thr Ala Pro Leu Leu Leu Gly
     290                 295                 300                
 Leu Ser Ala Ser Trp Leu Pro Trp His Gln Glu Asn Gly Pro Ala Gly
 305                 310                 315                 320
 Pro Val Pro Ser Phe Leu Gly Arg Ser Pro Met His Arg Val Thr Leu
                 325                 330                 335    
 Gln Glu Val Leu Thr Leu Leu Pro Asn Ser Met Ala Leu Leu Leu Gln
             340                 345                 350        
 Lys Glu Pro Trp Lys Glu Gln Thr Gln Lys Phe Ile Asp Trp Leu Phe
         355                 360                 365            
 Ser Ile Met Glu Ser Pro Lys Glu Ala Leu Ser Ala Gln Ser Arg Asp
     370                 375                 380                
 Leu Leu Lys Ala Thr Leu Leu Ser Leu Arg Val Leu Pro Glu Phe Lys
 385                 390                 395                 400
 Lys Lys Ala Val Trp Thr Arg Ala Tyr Gly Trp
                 405                 410    



      <210> 428
      <211> 81
      <212> PRT
      <213> Homo sapiens


      <400> 428
 Met Ala Tyr His Gly Leu Thr Val Pro Leu Ile Val Met Ser Val Phe
   1               5                  10                  15    
 Trp Gly Phe Val Gly Phe Leu Val Pro Trp Phe Ile Pro Lys Gly Pro
              20                  25                  30        
 Asn Arg Gly Val Ile Ile Thr Met Leu Val Thr Cys Ser Val Cys Cys
          35                  40                  45            
 Tyr Leu Phe Trp Leu Ile Ala Ile Leu Ala Gln Leu Asn Pro Leu Phe
      50                  55                  60                
 Gly Pro Gln Leu Lys Asn Glu Thr Ile Trp Tyr Leu Lys Tyr His Trp
  65                  70                  75                  80
 Pro
    



      <210> 429
      <211> 194
      <212> PRT
      <213> Homo sapiens


      <400> 429
 Met Leu His Gln Asp Glu Ser Asn Lys Arg Glu Lys Ile Lys Thr Lys
   1               5                  10                  15    
 Gly Met Asp Ser Glu Asp Asp Leu Arg Asp Glu Val Glu Asp Ala Val
              20                  25                  30        
 Gln Lys Val Cys Asn Ala Thr Gly Cys Ser Asp Phe Asn Leu Ile Val
          35                  40                  45            
 Gln Asn Leu Glu Ala Glu Asn Tyr Asn Ile Glu Ser Ala Ile Ile Ala
      50                  55                  60                
 Val Leu Arg Met Asn Gln Gly Lys Arg Asn Asn Ala Glu Glu Asn Leu
  65                  70                  75                  80
 Glu Pro Ser Gly Arg Val Leu Lys Gln Cys Gly Pro Leu Trp Glu Glu
                  85                  90                  95    
 Gly Gly Ser Gly Ala Arg Ile Phe Gly Asn Gln Gly Leu Asn Glu Gly
             100                 105                 110        
 Arg Thr Glu Asn Asn Lys Ala Gln Ala Ser Pro Ser Glu Glu Asn Lys
         115                 120                 125            
 Ala Asn Lys Asn Gln Leu Ala Lys Val Thr Asn Lys Gln Arg Arg Glu
     130                 135                 140                
 Gln Gln Trp Met Glu Lys Lys Lys Arg Gln Glu Glu Arg His Arg His
 145                 150                 155                 160
 Lys Ala Leu Glu Ser Arg Gly Ser His Arg Asp Asn Asn Arg Ser Glu
                 165                 170                 175    
 Ala Glu Ala Asn Thr Gln Val Thr Leu Val Lys Thr Phe Ala Ala Leu
             180                 185                 190        
 Asn Ile
        



      <210> 430
      <211> 142
      <212> PRT
      <213> Homo sapiens


      <400> 430
 Met Arg Thr Leu Leu Thr Ile Leu Thr Val Gly Ser Leu Ala Ala His
   1               5                  10                  15    
 Ala Pro Glu Asp Pro Ser Asp Leu Leu Gln His Val Lys Phe Gln Ser
              20                  25                  30        
 Ser Asn Phe Glu Asn Ile Leu Thr Trp Asp Ser Gly Pro Glu Gly Thr
          35                  40                  45            
 Pro Asp Thr Val Tyr Ser Ile Glu Tyr Lys Thr Tyr Gly Glu Arg Asp
      50                  55                  60                
 Trp Val Ala Lys Lys Gly Cys Gln Arg Ile Thr Arg Lys Ser Cys Asn
  65                  70                  75                  80
 Leu Thr Val Glu Thr Gly Asn Leu Thr Glu Leu Tyr Tyr Ala Arg Val
                  85                  90                  95    
 Thr Ala Val Ser Ala Gly Gly Arg Ser Ala Thr Lys Met Thr Asp Arg
             100                 105                 110        
 Phe Ser Ser Leu Gln His Thr Arg Arg Pro Thr Ala Phe Ile Thr Phe
         115                 120                 125            
 Ser Lys Glu Ser Val Asn Gln Gln Ser Tyr Pro Gln Ala Thr
     130                 135                 140        



      <210> 431
      <211> 401
      <212> PRT
      <213> Homo sapiens


      <400> 431
 Met Ser Ile Ala Leu Lys Gln Val Phe Asn Lys Asp Lys Thr Phe Arg
   1               5                  10                  15    
 Pro Lys Arg Lys Phe Glu Pro Gly Thr Gln Arg Phe Glu Leu His Lys
              20                  25                  30        
 Arg Ala Gln Ala Ser Leu Asn Ser Gly Val Asp Leu Lys Ala Ala Val
          35                  40                  45            
 Gln Leu Pro Ser Gly Glu Asp Gln Asn Asp Trp Val Ala Val His Val
      50                  55                  60                
 Val Asp Phe Phe Asn Arg Ile Asn Leu Ile Tyr Gly Thr Ile Cys Glu
  65                  70                  75                  80
 Phe Cys Thr Glu Arg Thr Cys Pro Val Met Ser Gly Gly Pro Lys Tyr
                  85                  90                  95    
 Glu Tyr Arg Trp Gln Asp Asp Leu Lys Tyr Lys Lys Pro Thr Ala Leu
             100                 105                 110        
 Pro Ala Pro Gln Tyr Met Asn Leu Leu Met Asp Trp Ile Glu Val Gln
         115                 120                 125            
 Ile Asn Asn Glu Glu Ile Phe Pro Thr Cys Val Val Asn Ser His Val
     130                 135                 140                
 Ser Phe Glu Val Gln Leu Arg Tyr His Val Leu Cys Glu Gly Phe His
 145                 150                 155                 160
 Pro Leu Glu Tyr Gln Leu Phe Lys Leu Cys Asn Met Ser Asn Ser Ser
                 165                 170                 175    
 Asp Tyr His Pro Leu Thr Leu Val Leu Val Thr Phe Lys Leu Leu Asp
             180                 185                 190        
 Gly Trp Met Asp Gly Trp Met Asp Gly Leu Gly Ile Leu Leu Gln Leu
         195                 200                 205            
 Thr Gly Arg Lys Glu Val Ala Lys Tyr Cys Gly Leu Thr Tyr Tyr Gly
     210                 215                 220                
 Pro Gln Ile Ser His Pro Tyr Leu Ala Ser Gln Ser Gly Lys Glu Lys
 225                 230                 235                 240
 Ala Cys Ser Gln Gly His Leu Ser Ser His Val Phe Glu Glu Lys Cys
                 245                 250                 255    
 Glu Gln Met Cys Gln Arg Glu Met Glu Glu Glu Glu Ala Asn Val Glu
             260                 265                 270        
 Gln Cys Asp Ile Val Ser Ser Arg Ala His Thr Leu Glu Met Val Asp
         275                 280                 285            
 Leu Gly Val Lys Ile Gly Gln Ser Asp Leu Arg Ser Ile Tyr Leu Thr
     290                 295                 300                
 Thr Ser Leu Tyr Asn Thr Val Thr Lys Ser His Lys Ala Gln Gly Trp
 305                 310                 315                 320
 Phe Ile Glu Leu Ala Ser Pro Gln Glu Met Thr Phe Gly Pro Trp Thr
                 325                 330                 335    
 Thr Gly Tyr Ala Arg Pro Gly Met Ser Asp Ser Leu Ala Gln Gly Ala
             340                 345                 350        
 Leu Lys Ser Trp Arg Ala Ala Glu Ser Thr His Pro Leu Ala Met Ser
         355                 360                 365            
 Glu Ile Phe Met Ala Ala Pro Pro Ile Thr Gly Pro Glu Ala Gln Gln
     370                 375                 380                
 Glu Lys Val Val Leu Trp Ala Gly Pro Arg Ile Pro Val Leu Tyr Ala
 385                 390                 395                 400
 Ala
    



      <210> 432
      <211> 275
      <212> PRT
      <213> Homo sapiens


      <400> 432
 Met Ser Arg Glu Leu Ala Pro Leu Leu Leu Leu Leu Leu Ser Ile His
   1               5                  10                  15    
 Ser Ala Leu Ala Met Arg Ile Cys Ser Phe Asn Val Arg Ser Phe Gly
              20                  25                  30        
 Glu Ser Lys Gln Glu Asp Lys Asn Ala Met Asp Val Ile Val Lys Val
          35                  40                  45            
 Ile Lys Arg Cys Asp Ile Ile Leu Val Met Glu Ile Lys Asp Ser Asn
      50                  55                  60                
 Asn Arg Ile Cys Pro Ile Leu Met Glu Lys Leu Asn Arg Glu Lys Leu
  65                  70                  75                  80
 Val Ser Val Lys Arg Ser Tyr His Tyr His Asp Tyr Gln Asp Gly Asp
                  85                  90                  95    
 Ala Asp Val Phe Ser Arg Glu Pro Phe Val Val Trp Phe Gln Ser Pro
             100                 105                 110        
 His Thr Ala Val Lys Asp Phe Val Ile Ile Pro Leu His Thr Thr Pro
         115                 120                 125            
 Glu Thr Ser Val Lys Glu Ile Asp Glu Leu Val Glu Val Tyr Thr Asp
     130                 135                 140                
 Val Lys His Arg Trp Lys Ala Glu Asn Phe Ile Phe Met Gly Asp Phe
 145                 150                 155                 160
 Asn Ala Gly Cys Ser Tyr Val Pro Lys Lys Ala Trp Lys Asn Ile Arg
                 165                 170                 175    
 Leu Arg Thr Asp Pro Arg Phe Val Trp Leu Ile Gly Asp Gln Glu Asp
             180                 185                 190        
 Thr Thr Val Lys Lys Ser Thr Asn Cys Ala Tyr Asp Arg Ile Val Leu
         195                 200                 205            
 Arg Gly Gln Glu Ile Val Ser Ser Val Val Pro Lys Ser Asn Ser Val
     210                 215                 220                
 Phe Asp Phe Gln Lys Ala Tyr Lys Leu Thr Glu Glu Glu Ala Leu Asp
 225                 230                 235                 240
 Val Ser Asp His Phe Pro Val Glu Phe Lys Leu Gln Ser Ser Arg Ala
                 245                 250                 255    
 Phe Thr Asn Ser Lys Lys Ser Val Thr Leu Arg Lys Lys Thr Lys Ser
             260                 265                 270        
 Lys Arg Ser
         275



      <210> 433
      <211> 92
      <212> PRT
      <213> Homo sapiens


      <400> 433
 Met Lys Leu Cys Val Thr Val Leu Ser Leu Leu Val Leu Val Ala Ala
   1               5                  10                  15    
 Phe Cys Ser Leu Ala Leu Ser Ala Pro Met Gly Ser Asp Pro Pro Thr
              20                  25                  30        
 Ala Cys Cys Phe Ser Tyr Thr Ala Arg Lys Leu Pro Arg Asn Phe Val
          35                  40                  45            
 Val Asp Tyr Tyr Glu Thr Ser Ser Leu Cys Ser Gln Pro Ala Val Val
      50                  55                  60                
 Phe Gln Thr Lys Arg Gly Lys Gln Val Cys Ala Asp Pro Ser Glu Ser
  65                  70                  75                  80
 Trp Val Gln Glu Tyr Val Tyr Asp Leu Glu Leu Asn
                  85                  90        



      <210> 434
      <211> 54
      <212> PRT
      <213> Homo sapiens


      <400> 434
 Met Glu Tyr Leu Glu Phe Val Cys His Ala Pro Ser Glu Tyr Phe Lys
   1               5                  10                  15    
 Ser Arg Ser Ser Pro Phe Pro Thr Val Pro Thr Arg Pro Glu Lys Gly
              20                  25                  30        
 Tyr Ile Trp Thr His Val Gly Pro Thr Pro Ala Ile Thr Ile Lys Glu
          35                  40                  45            
 Ser Val Ala Asn His Leu
      50                



      <210> 435
      <211> 87
      <212> PRT
      <213> Homo sapiens


      <400> 435
 Met Pro Ala Pro Glu Gly Arg Phe Val Arg Val Asn Phe Ser Lys Ser
   1               5                  10                  15    
 Leu Gln Val Leu Thr Val Ala Thr Val Leu Ala Pro Ser Val Ser Ser
              20                  25                  30        
 Leu Thr Leu Pro Val Ser Leu Pro Val Gly Gly Lys Arg Gly Val Pro
          35                  40                  45            
 Ile Ser Gly His Ser Val Asn Thr Glu Glu Ser Cys Ala Gly His Arg
      50                  55                  60                
 Glu Asp Ser Pro Met Ile Leu Lys Val Gln Ala Cys Gly Leu Glu Pro
  65                  70                  75                  80
 Lys Gly Pro Val Pro Trp Ile
                  85        



      <210> 436
      <211> 335
      <212> PRT
      <213> Homo sapiens


      <400> 436
 Met Leu Leu Pro Phe Ile Lys Leu Pro Thr Thr Gly Asn Ser Leu Ala
   1               5                  10                  15    
 Lys Ile Gln Thr Val Gly Gln Asn Gln Gln Lys Val Asn Arg Val Leu
              20                  25                  30        
 Met Gly Pro Arg Ser Ile Gln Lys Arg His Phe Lys Glu Val Gly Arg
          35                  40                  45            
 Gln Ser Ile Arg Arg Glu Gln Gly Ala Gln Ala Ser Val Glu Asn Ala
      50                  55                  60                
 Ala Glu Glu Lys Arg Leu Gly Ser Pro Ala Pro Arg Glu Leu Glu Gln
  65                  70                  75                  80
 Pro His Thr Gln Gln Gly Pro Glu Lys Leu Ala Gly Asn Ala Ile Tyr
                  85                  90                  95    
 Thr Lys Pro Ser Phe Thr Gln Glu His Lys Ala Ala Val Ser Val Leu
             100                 105                 110        
 Thr Pro Phe Ser Lys Gly Ala Pro Ser Thr Ser Ser Pro Ala Lys Ala
         115                 120                 125            
 Leu Pro Gln Val Arg Asp Arg Trp Lys Asp Asn Thr His Thr Ile Ser
     130                 135                 140                
 Ile Leu Glu Ser Ala Lys Ala Arg Val Thr Asn Met Lys Ala Ser Lys
 145                 150                 155                 160
 Pro Ile Ser His Ser Arg Lys Lys Tyr Arg Phe His Lys Thr Arg Ser
                 165                 170                 175    
 Arg Met Thr His Arg Thr Pro Lys Val Lys Lys Ser Pro Lys Phe Arg
             180                 185                 190        
 Lys Lys Ser Tyr Leu Ser Arg Leu Met Leu Ala Asn Arg Pro Pro Phe
         195                 200                 205            
 Ser Ala Ala Lys Ser Leu Ile Asn Ser Pro Ser Gln Gly Ala Phe Ser
     210                 215                 220                
 Ser Leu Gly Asp Leu Ser Pro Gln Glu Asn Pro Phe Leu Glu Val Ser
 225                 230                 235                 240
 Ala Pro Ser Glu His Phe Ile Glu Thr Thr Asn Ile Lys Asp Thr Thr
                 245                 250                 255    
 Ala Arg Asn Ala Leu Glu Glu Asn Val Phe Met Glu Asn Thr Asn Met
             260                 265                 270        
 Pro Glu Val Thr Ile Ser Glu Asn Thr Asn Tyr Asn His Pro Pro Glu
         275                 280                 285            
 Ala Asp Ser Ala Gly Thr Ala Phe Asn Leu Gly Pro Thr Val Lys Gln
     290                 295                 300                
 Thr Glu Thr Lys Trp Glu Tyr Asn Asn Val Gly Thr Asp Leu Ser Pro
 305                 310                 315                 320
 Glu Pro Lys Ser Phe Asn Tyr Pro Leu Leu Ser Leu Lys Phe Ser
                 325                 330                 335



      <210> 437
      <211> 235
      <212> PRT
      <213> Homo sapiens


      <400> 437
 Met Asp Arg Glu Thr Leu Leu Thr Lys Gly Trp Ser Ser Ser Phe Gln
   1               5                  10                  15    
 Ile Asn Phe Leu Leu Glu Ala Pro Pro Ser Pro Arg Pro Ser Leu Phe
              20                  25                  30        
 Ser His Leu Glu Ser Pro Phe Gly Ile Leu Glu Leu Ser Thr Met Gly
          35                  40                  45            
 Thr Pro Asn Asp Gln Ala Val Leu Gln Ala Ile Phe Asn Pro Asp Thr
      50                  55                  60                
 Pro Phe Gly Asp Ile Val Gly Leu Asp Leu Gly Glu Glu Ala Glu Lys
  65                  70                  75                  80
 Glu Glu Arg Glu Glu Asp Glu Val Phe Pro Gln Ala Gln Leu Glu Gln
                  85                  90                  95    
 Ser Lys Ala Leu Glu Leu Gln Gly Val Met Ala Ala Glu Ala Gly Asp
             100                 105                 110        
 Leu Ser Thr Ala Leu Glu Arg Phe Gly Gln Ala Ile Cys Leu Leu Pro
         115                 120                 125            
 Glu Arg Ala Ser Ala Tyr Asn Asn Arg Ala Gln Ala Arg Arg Leu Gln
     130                 135                 140                
 Gly Asp Val Ala Gly Ala Leu Glu Asp Leu Glu Arg Ala Val Glu Leu
 145                 150                 155                 160
 Ser Gly Gly Arg Gly Arg Ala Ala Arg Gln Ser Phe Val Gln Arg Gly
                 165                 170                 175    
 Leu Leu Ala Arg Leu Gln Gly Arg Asp Asp Asp Ala Arg Arg Asp Phe
             180                 185                 190        
 Glu Arg Ala Ala Arg Leu Gly Ser Pro Phe Ala Arg Arg Gln Leu Val
         195                 200                 205            
 Leu Leu Asn Pro Tyr Ala Ala Leu Cys Asn Arg Met Leu Ala Asp Met
     210                 215                 220                
 Met Gly Gln Leu Arg Arg Pro Arg Asp Ser Arg
 225                 230                 235



      <210> 438
      <211> 357
      <212> PRT
      <213> Homo sapiens


      <400> 438
 Met Asp Ser Val Glu Lys Thr Thr Asn Arg Ser Glu Gln Lys Ser Arg
   1               5                  10                  15    
 Lys Phe Leu Lys Ser Leu Ile Arg Lys Gln Pro Gln Glu Leu Leu Leu
              20                  25                  30        
 Val Ile Gly Thr Gly Val Ser Ala Ala Val Ala Pro Gly Ile Pro Ala
          35                  40                  45            
 Leu Cys Ser Trp Arg Ser Cys Ile Glu Ala Val Ile Glu Ala Ala Glu
      50                  55                  60                
 Gln Leu Glu Val Leu His Pro Gly Asp Val Ala Glu Phe Arg Arg Lys
  65                  70                  75                  80
 Val Thr Lys Asp Arg Asp Leu Leu Val Val Ala His Asp Leu Ile Arg
                  85                  90                  95    
 Lys Met Ser Pro Arg Thr Gly Asp Ala Lys Pro Ser Phe Phe Gln Asp
             100                 105                 110        
 Cys Leu Met Glu Val Phe Asp Asp Leu Glu Gln His Ile Arg Ser Pro
         115                 120                 125            
 Leu Val Leu Gln Ser Ile Leu Ser Leu Met Asp Arg Gly Ala Met Val
     130                 135                 140                
 Leu Thr Thr Asn Tyr Asp Asn Leu Leu Glu Ala Phe Gly Arg Arg Gln
 145                 150                 155                 160
 Asn Lys Pro Met Glu Ser Leu Asp Leu Lys Asp Lys Thr Lys Val Leu
                 165                 170                 175    
 Glu Trp Ala Arg Gly His Met Lys Tyr Gly Val Leu His Ile His Gly
             180                 185                 190        
 Leu Tyr Thr Asp Pro Cys Gly Val Val Leu Asp Pro Ser Gly Tyr Lys
         195                 200                 205            
 Asp Val Thr Gln Asp Ala Glu Val Met Glu Val Leu Gln Asn Leu Tyr
     210                 215                 220                
 Arg Thr Lys Ser Phe Leu Phe Val Gly Cys Gly Glu Thr Leu Arg Asp
 225                 230                 235                 240
 Gln Ile Phe Gln Ala Leu Phe Leu Tyr Ser Val Pro Asn Lys Val Asp
                 245                 250                 255    
 Leu Glu His Tyr Met Leu Val Leu Lys Glu Asn Glu Asp His Phe Phe
             260                 265                 270        
 Lys His Gln Ala Asp Met Leu Leu His Gly Ile Lys Val Val Ser Tyr
         275                 280                 285            
 Gly Asp Cys Phe Asp His Phe Pro Gly Tyr Val Gln Asp Leu Ala Thr
     290                 295                 300                
 Gln Ile Cys Lys Gln Gln Ser Pro Asp Ala Asp Arg Val Asp Ser Thr
 305                 310                 315                 320
 Thr Leu Leu Gly Asn Ala Cys Gln Asp Cys Ala Lys Arg Lys Leu Glu
                 325                 330                 335    
 Glu Asn Gly Ile Glu Val Ser Lys Lys Arg Thr Gln Ser Asp Thr Asp
             340                 345                 350        
 Asp Ala Gly Gly Ser
         355        



      <210> 439
      <211> 71
      <212> PRT
      <213> Homo sapiens


      <400> 439
 Met Ala Asp Ser Met Gln Glu Lys Leu Arg Met Ala Gly Gln Met Leu
   1               5                  10                  15    
 Leu Gln Thr Phe Phe Asn Ile Asp His Ile Ser Pro Asn Lys Lys Ala
              20                  25                  30        
 His Pro Asn Met Glu Ala Val Pro Pro Glu Ser Gly Glu Ser Thr Asp
          35                  40                  45            
 Ala Leu Lys Leu Cys Ser His Glu Glu Phe Leu Arg Leu Cys Lys Lys
      50                  55                  60                
 Glu Leu Lys Arg Ser Ile Gln
  65                  70    



      <210> 440
      <211> 112
      <212> PRT
      <213> Homo sapiens


      <400> 440
 Met Ala Glu Ala His Lys Glu Ala Met Ser Arg Lys Leu Gly Gln Ser
   1               5                  10                  15    
 Glu Ser Gln Gly Pro Pro Arg Ala Phe Ala Lys Val Asn Ser Ile Ser
              20                  25                  30        
 Pro Gly Ser Pro Ala Ser Ile Ala Gly Leu Gln Val Asp Asp Glu Ile
          35                  40                  45            
 Val Glu Phe Gly Ser Val Asn Thr Gln Asn Phe Gln Ser Leu His Asn
      50                  55                  60                
 Ile Gly Ser Val Val Gln His Ser Glu Gly Lys Pro Leu Asn Val Thr
  65                  70                  75                  80
 Val Ile Arg Arg Gly Glu Lys His Gln Leu Arg Leu Val Pro Thr Arg
                  85                  90                  95    
 Trp Ala Gly Lys Gly Leu Leu Gly Cys Asn Ile Ile Pro Leu Gln Arg
             100                 105                 110        





      <210> 441
      <211> 90
      <212> PRT
      <213> Homo sapiens


      <400> 441
 Met Ser Gly Ser Phe Tyr Phe Val Ile Val Gly His His Asp Asn Pro
   1               5                  10                  15    
 Val Phe Glu Met Glu Phe Leu Pro Ala Gly Lys Ala Glu Ser Lys Asp
              20                  25                  30        
 Asp His Arg His Leu Asn Gln Phe Ile Ala His Ala Ala Leu Asp Leu
          35                  40                  45            
 Val Asp Glu Asn Met Trp Leu Ser Asn Asn Met Tyr Leu Lys Thr Val
      50                  55                  60                
 Asp Lys Phe Asn Glu Trp Phe Val Ser Ala Phe Val Thr Ala Gly His
  65                  70                  75                  80
 Ile Leu Thr Phe Leu Val Lys Val Thr Asn
                  85                  90



      <210> 442
      <211> 962
      <212> PRT
      <213> Homo sapiens


      <400> 442
 Met Ala Thr Ala Ala Thr Ser Pro Ala Leu Lys Arg Leu Asp Leu Arg
   1               5                  10                  15    
 Asp Pro Ala Ala Leu Phe Glu Thr His Gly Ala Glu Glu Ile Arg Gly
              20                  25                  30        
 Leu Glu Arg Gln Val Arg Ala Glu Ile Glu His Lys Lys Glu Glu Leu
          35                  40                  45            
 Arg Gln Met Val Gly Glu Arg Tyr Arg Asp Leu Ile Glu Ala Ala Asp
      50                  55                  60                
 Thr Ile Gly Gln Met Arg Arg Cys Ala Val Gly Leu Val Asp Ala Val
  65                  70                  75                  80
 Lys Ala Thr Asp Gln Tyr Cys Ala Arg Leu Arg Gln Ala Gly Ser Ala
                  85                  90                  95    
 Ala Pro Arg Pro Pro Arg Ala Gln Gln Pro Gln Gln Pro Ser Gln Glu
             100                 105                 110        
 Lys Phe Tyr Ser Met Ala Ala Gln Ile Lys Leu Leu Leu Glu Ile Pro
         115                 120                 125            
 Glu Lys Ile Trp Ser Ser Met Glu Ala Ser Gln Cys Leu His Ala Thr
     130                 135                 140                
 Gln Leu Tyr Leu Leu Cys Cys His Leu His Ser Leu Leu Gln Leu Asp
 145                 150                 155                 160
 Ser Ser Ser Ser Arg Tyr Ser Pro Val Leu Ser Arg Phe Pro Ile Leu
                 165                 170                 175    
 Ile Arg Gln Val Ala Ala Ala Ser His Phe Arg Ser Thr Ile Leu His
             180                 185                 190        
 Glu Ser Lys Met Leu Leu Lys Cys Gln Gly Val Ser Asp Gln Ala Val
         195                 200                 205            
 Ala Glu Ala Leu Cys Ser Ile Met Leu Leu Glu Glu Ser Ser Pro Arg
     210                 215                 220                
 Gln Ala Leu Thr Asp Phe Leu Leu Ala Arg Lys Ala Thr Ile Gln Lys
 225                 230                 235                 240
 Leu Leu Asn Gln Pro His His Gly Ala Gly Ile Lys Ala Gln Ile Cys
                 245                 250                 255    
 Ser Leu Val Glu Leu Leu Ala Thr Thr Leu Lys Gln Ala His Ala Leu
             260                 265                 270        
 Phe Tyr Thr Leu Pro Glu Gly Leu Leu Pro Asp Pro Ala Leu Pro Cys
         275                 280                 285            
 Gly Leu Leu Phe Ser Thr Leu Glu Thr Ile Thr Gly Gln His Pro Ala
     290                 295                 300                
 Gly Lys Gly Thr Gly Val Leu Gln Glu Glu Met Lys Leu Cys Ser Trp
 305                 310                 315                 320
 Phe Lys His Leu Pro Ala Ser Ile Val Glu Phe Gln Pro Thr Leu Arg
                 325                 330                 335    
 Thr Leu Ala His Pro Ile Ser Gln Glu Tyr Leu Lys Asp Thr Leu Gln
             340                 345                 350        
 Lys Trp Ile His Met Cys Asn Glu Asp Ile Lys Asn Gly Ile Thr Asn
         355                 360                 365            
 Leu Leu Met Tyr Val Lys Ser Met Lys Gly Leu Ala Gly Ile Arg Asp
     370                 375                 380                
 Ala Met Trp Glu Leu Leu Thr Ser Glu Ser Thr Asn His Ser Trp Asp
 385                 390                 395                 400
 Val Leu Cys Arg Arg Leu Leu Glu Lys Pro Leu Leu Phe Trp Glu Asp
                 405                 410                 415    
 Met Met Gln Gln Leu Phe Leu Asp Arg Leu Gln Thr Leu Thr Lys Glu
             420                 425                 430        
 Gly Phe Asp Ser Ile Ser Ser Ser Ser Lys Glu Leu Leu Val Ser Ala
         435                 440                 445            
 Leu Gln Glu Leu Glu Ser Ser Thr Ser Asn Ser Pro Ser Asn Lys His
     450                 455                 460                
 Ile His Phe Glu Tyr Asn Met Ser Leu Phe Leu Trp Ser Glu Ser Pro
 465                 470                 475                 480
 Asn Asp Leu Pro Ser Asp Ala Ala Trp Val Ser Val Ala Asn Arg Gly
                 485                 490                 495    
 Gln Phe Ala Ser Ser Gly Leu Ser Met Lys Ala Gln Ala Ile Ser Pro
             500                 505                 510        
 Cys Val Gln Asn Phe Cys Ser Ala Leu Asp Ser Lys Leu Lys Val Lys
         515                 520                 525            
 Leu Asp Asp Leu Leu Ala Tyr Leu Pro Ser Asp Asp Ser Ser Leu Pro
     530                 535                 540                
 Lys Asp Val Ser Pro Thr Gln Ala Lys Ser Ser Ala Phe Asp Arg Tyr
 545                 550                 555                 560
 Ala Asp Ala Gly Thr Val Gln Glu Met Leu Arg Thr Gln Ser Val Ala
                 565                 570                 575    
 Cys Ile Lys His Ile Val Asp Cys Ile Arg Ala Glu Leu Gln Ser Ile
             580                 585                 590        
 Glu Glu Gly Val Gln Gly Gln Gln Asp Ala Leu Asn Ser Ala Lys Leu
         595                 600                 605            
 His Ser Val Leu Phe Met Ala Arg Leu Cys Gln Ser Leu Gly Glu Leu
     610                 615                 620                
 Cys Pro His Leu Lys Gln Cys Ile Leu Gly Lys Ser Glu Ser Ser Glu
 625                 630                 635                 640
 Lys Pro Ala Arg Glu Phe Arg Ala Leu Arg Lys Gln Gly Lys Val Lys
                 645                 650                 655    
 Thr Gln Glu Ile Ile Pro Thr Gln Ala Lys Trp Gln Glu Val Lys Glu
             660                 665                 670        
 Val Leu Leu Gln Gln Ser Val Met Gly Tyr Gln Val Trp Ser Ser Ala
         675                 680                 685            
 Val Val Lys Val Leu Ile His Gly Phe Thr Gln Ser Leu Leu Leu Asp
     690                 695                 700                
 Asp Ala Gly Ser Val Leu Ala Thr Ala Thr Ser Trp Asp Glu Leu Glu
 705                 710                 715                 720
 Ile Gln Glu Glu Ala Glu Ser Gly Ser Ser Val Thr Ser Lys Ile Arg
                 725                 730                 735    
 Leu Pro Ala Gln Pro Ser Trp Tyr Val Gln Ser Phe Leu Phe Ser Leu
             740                 745                 750        
 Cys Gln Glu Ile Asn Arg Val Gly Gly His Ala Leu Pro Lys Val Thr
         755                 760                 765            
 Leu Gln Glu Met Leu Lys Ser Cys Met Val Gln Val Val Ala Ala Tyr
     770                 775                 780                
 Glu Lys Leu Ser Glu Glu Lys Gln Ile Lys Lys Glu Gly Ala Phe Pro
 785                 790                 795                 800
 Val Thr Gln Asn Arg Ala Leu Gln Leu Leu Tyr Asp Leu Arg Tyr Leu
                 805                 810                 815    
 Asn Ile Val Leu Thr Ala Lys Gly Asp Glu Val Lys Ser Gly Arg Ser
             820                 825                 830        
 Lys Pro Asp Ser Arg Ile Glu Lys Val Thr Asp His Leu Glu Ala Leu
         835                 840                 845            
 Ile Asp Pro Phe Asp Leu Asp Val Phe Thr Pro His Leu Asn Ser Asn
     850                 855                 860                
 Leu His Arg Leu Val Gln Arg Thr Ser Val Leu Phe Gly Leu Val Thr
 865                 870                 875                 880
 Gly Thr Glu Asn Gln Leu Ala Pro Arg Ser Ser Thr Phe Asn Ser Gln
                 885                 890                 895    
 Glu Pro His Asn Ile Leu Pro Leu Ala Ser Ser Gln Ile Arg Phe Gly
             900                 905                 910        
 Leu Leu Pro Leu Ser Met Thr Ser Thr Arg Lys Ala Lys Ser Thr Arg
         915                 920                 925            
 Asn Ile Glu Thr Lys Ala Gln Val Gly Ala Lys Ser Lys Arg Leu Ile
     930                 935                 940                
 Arg Gly Trp Val Pro Thr Ser His Arg Ala Thr His Asp Gln Leu Pro
 945                 950                 955                 960
 Phe Lys
        



      <210> 443
      <211> 1002
      <212> PRT
      <213> Homo sapiens


      <400> 443
 Met Ala Thr Ala Ala Thr Ser Pro Ala Leu Lys Arg Leu Asp Leu Arg
   1               5                  10                  15    
 Asp Pro Ala Ala Leu Phe Glu Thr His Gly Ala Glu Glu Ile Arg Gly
              20                  25                  30        
 Leu Glu Arg Gln Val Arg Ala Glu Ile Glu His Lys Lys Glu Glu Leu
          35                  40                  45            
 Arg Gln Met Val Gly Glu Arg Tyr Arg Asp Leu Ile Glu Ala Ala Asp
      50                  55                  60                
 Thr Ile Gly Gln Met Arg Arg Cys Ala Val Gly Leu Val Asp Ala Val
  65                  70                  75                  80
 Lys Ala Thr Asp Gln Tyr Cys Ala Arg Leu Arg Gln Ala Gly Ser Ala
                  85                  90                  95    
 Ala Pro Arg Pro Pro Arg Ala Gln Gln Pro Gln Gln Pro Ser Gln Glu
             100                 105                 110        
 Lys Phe Tyr Ser Met Ala Ala Gln Ile Lys Leu Leu Leu Glu Ile Pro
         115                 120                 125            
 Glu Lys Ile Trp Ser Ser Met Glu Ala Ser Gln Cys Leu His Ala Thr
     130                 135                 140                
 Gln Leu Tyr Leu Leu Cys Cys His Leu His Ser Leu Leu Gln Leu Asp
 145                 150                 155                 160
 Ser Ser Ser Ser Arg Tyr Ser Pro Val Leu Ser Arg Phe Pro Ile Leu
                 165                 170                 175    
 Ile Arg Gln Val Ala Ala Ala Ser His Phe Arg Ser Thr Ile Leu His
             180                 185                 190        
 Glu Ser Lys Met Leu Leu Lys Cys Gln Gly Val Ser Asp Gln Ala Val
         195                 200                 205            
 Ala Glu Ala Leu Cys Ser Ile Met Leu Leu Glu Glu Ser Ser Pro Arg
     210                 215                 220                
 Gln Ala Leu Thr Asp Phe Leu Leu Ala Arg Lys Ala Thr Ile Gln Lys
 225                 230                 235                 240
 Leu Leu Asn Gln Pro His His Gly Ala Gly Ile Lys Ala Gln Ile Cys
                 245                 250                 255    
 Ser Leu Val Glu Leu Leu Ala Thr Thr Leu Lys Gln Ala His Ala Leu
             260                 265                 270        
 Phe Tyr Thr Leu Pro Glu Gly Leu Leu Pro Asp Pro Ala Leu Pro Cys
         275                 280                 285            
 Gly Leu Leu Phe Ser Thr Leu Glu Thr Ile Thr Gly Gln His Pro Ala
     290                 295                 300                
 Ala Val Gly Met Asp Asp Ile Ile Ser Lys Glu Met Thr Glu Asp Ser
 305                 310                 315                 320
 Ala Leu Trp Asn Ser Arg Asn Pro Arg Ser Asn Gly Gly Val Ser Lys
                 325                 330                 335    
 Ile Asp Lys Gly Asp Thr Ala Lys Gly Lys Gly Thr Gly Val Leu Gln
             340                 345                 350        
 Glu Glu Met Lys Leu Cys Ser Trp Phe Lys His Leu Pro Ala Ser Ile
         355                 360                 365            
 Val Glu Phe Gln Pro Thr Leu Arg Thr Leu Ala His Pro Ile Ser Gln
     370                 375                 380                
 Glu Tyr Leu Lys Asp Thr Leu Gln Lys Trp Ile His Met Cys Asn Glu
 385                 390                 395                 400
 Asp Ile Lys Asn Gly Ile Thr Asn Leu Leu Met Tyr Val Lys Ser Met
                 405                 410                 415    
 Lys Gly Leu Ala Gly Ile Arg Asp Ala Met Trp Glu Leu Leu Thr Ser
             420                 425                 430        
 Glu Ser Thr Asn His Ser Trp Asp Val Leu Cys Arg Arg Leu Leu Glu
         435                 440                 445            
 Lys Pro Leu Leu Phe Trp Glu Asp Met Met Gln Gln Leu Phe Leu Asp
     450                 455                 460                
 Arg Leu Gln Thr Leu Thr Lys Glu Gly Phe Asp Ser Ile Ser Ser Ser
 465                 470                 475                 480
 Ser Lys Glu Leu Leu Val Ser Ala Leu Gln Glu Leu Glu Ser Ser Thr
                 485                 490                 495    
 Ser Asn Ser Pro Ser Asn Lys His Ile His Phe Glu Tyr Asn Met Ser
             500                 505                 510        
 Leu Phe Leu Trp Ser Glu Ser Pro Asn Asp Leu Pro Ser Asp Ala Ala
         515                 520                 525            
 Trp Val Ser Val Ala Asn Arg Gly Gln Phe Ala Ser Ser Gly Leu Ser
     530                 535                 540                
 Met Lys Ala Gln Ala Ile Ser Pro Cys Val Gln Asn Phe Cys Ser Ala
 545                 550                 555                 560
 Leu Asp Ser Lys Leu Lys Val Lys Leu Asp Asp Leu Leu Ala Tyr Leu
                 565                 570                 575    
 Pro Ser Asp Asp Ser Ser Leu Pro Lys Asp Val Ser Pro Thr Gln Ala
             580                 585                 590        
 Lys Ser Ser Ala Phe Asp Arg Tyr Ala Asp Ala Gly Thr Val Gln Glu
         595                 600                 605            
 Met Leu Arg Thr Gln Ser Val Ala Cys Ile Lys His Ile Val Asp Cys
     610                 615                 620                
 Ile Arg Ala Glu Leu Gln Ser Ile Glu Glu Gly Val Gln Gly Gln Gln
 625                 630                 635                 640
 Asp Ala Leu Asn Ser Ala Lys Leu His Ser Val Leu Phe Met Ala Arg
                 645                 650                 655    
 Leu Cys Gln Ser Leu Gly Glu Leu Cys Pro His Leu Lys Gln Cys Ile
             660                 665                 670        
 Leu Gly Lys Ser Glu Ser Ser Glu Lys Pro Ala Arg Glu Phe Arg Ala
         675                 680                 685            
 Leu Arg Lys Gln Gly Lys Val Lys Thr Gln Glu Ile Ile Pro Thr Gln
     690                 695                 700                
 Ala Lys Trp Gln Glu Val Lys Glu Val Leu Leu Gln Gln Ser Val Met
 705                 710                 715                 720
 Gly Tyr Gln Val Trp Ser Ser Ala Val Val Lys Val Leu Ile His Gly
                 725                 730                 735    
 Phe Thr Gln Ser Leu Leu Leu Asp Asp Ala Gly Ser Val Leu Ala Thr
             740                 745                 750        
 Ala Thr Ser Trp Asp Glu Leu Glu Ile Gln Glu Glu Ala Glu Ser Gly
         755                 760                 765            
 Ser Ser Val Thr Ser Lys Ile Arg Leu Pro Ala Gln Pro Ser Trp Tyr
     770                 775                 780                
 Val Gln Ser Phe Leu Phe Ser Leu Cys Gln Glu Ile Asn Arg Val Gly
 785                 790                 795                 800
 Gly His Ala Leu Pro Lys Val Thr Leu Gln Glu Met Leu Lys Ser Cys
                 805                 810                 815    
 Met Val Gln Val Val Ala Ala Tyr Glu Lys Leu Ser Glu Glu Lys Gln
             820                 825                 830        
 Ile Lys Lys Glu Gly Ala Phe Pro Val Thr Gln Asn Arg Ala Leu Gln
         835                 840                 845            
 Leu Leu Tyr Asp Leu Arg Tyr Leu Asn Ile Val Leu Thr Ala Lys Gly
     850                 855                 860                
 Asp Glu Val Lys Ser Gly Arg Ser Lys Pro Asp Ser Arg Ile Glu Lys
 865                 870                 875                 880
 Val Thr Asp His Leu Glu Ala Leu Ile Asp Pro Phe Asp Leu Asp Val
                 885                 890                 895    
 Phe Thr Pro His Leu Asn Ser Asn Leu His Arg Leu Val Gln Arg Thr
             900                 905                 910        
 Ser Val Leu Phe Gly Leu Val Thr Gly Thr Glu Asn Gln Leu Ala Pro
         915                 920                 925            
 Arg Ser Ser Thr Phe Asn Ser Gln Glu Pro His Asn Ile Leu Pro Leu
     930                 935                 940                
 Ala Ser Ser Gln Ile Arg Phe Gly Leu Leu Pro Leu Ser Met Thr Ser
 945                 950                 955                 960
 Thr Arg Lys Ala Lys Ser Thr Arg Asn Ile Glu Thr Lys Ala Gln Val
                 965                 970                 975    
 Gly Ala Lys Ser Lys Arg Leu Ile Arg Gly Trp Val Pro Thr Ser His
             980                 985                 990        
 Arg Ala Thr His Asp Gln Leu Pro Phe Lys
         995                1000        



      <210> 444
      <211> 256
      <212> PRT
      <213> Homo sapiens


      <400> 444
 Met Pro Leu His Lys Tyr Pro Val Trp Leu Trp Lys Arg Leu Gln Leu
   1               5                  10                  15    
 Arg Glu Gly Ile Cys Ser Arg Leu Pro Gly His Tyr Leu Arg Ser Leu
              20                  25                  30        
 Glu Glu Glu Arg Thr Pro Thr Pro Val His Tyr Arg Pro His Gly Ala
          35                  40                  45            
 Lys Phe Lys Ile Asn Pro Lys Asn Gly Gln Arg Glu Arg Val Glu Asp
      50                  55                  60                
 Val Pro Ile Pro Ile Tyr Phe Pro Pro Glu Ser Gln Arg Gly Leu Trp
  65                  70                  75                  80
 Gly Gly Glu Gly Trp Ile Leu Gly Gln Ile Tyr Ala Asn Asn Asp Lys
                  85                  90                  95    
 Leu Ser Lys Arg Leu Lys Lys Val Trp Lys Pro Gln Leu Phe Glu Arg
             100                 105                 110        
 Glu Phe Tyr Ser Glu Ile Leu Asp Lys Lys Phe Thr Val Thr Val Thr
         115                 120                 125            
 Met Arg Thr Leu Asp Leu Ile Asp Glu Ala Tyr Gly Leu Asp Phe Tyr
     130                 135                 140                
 Ile Leu Lys Thr Pro Lys Glu Asp Leu Cys Ser Lys Phe Gly Met Asp
 145                 150                 155                 160
 Leu Lys Arg Gly Met Gln Leu Arg Leu Ala Arg Gln Asp Pro Gln Leu
                 165                 170                 175    
 His Pro Glu Asp Pro Glu Arg Arg Ala Ala Ile Tyr Asp Lys Tyr Lys
             180                 185                 190        
 Glu Phe Ala Ile Pro Glu Glu Glu Ala Glu Trp Val Gly Leu Thr Leu
         195                 200                 205            
 Glu Glu Ala Ile Glu Lys Gln Arg Leu Leu Glu Glu Lys Asp Pro Val
     210                 215                 220                
 Pro Leu Phe Lys Ile Tyr Val Ala Glu Leu Ile Gln Gln Leu Gln Gln
 225                 230                 235                 240
 Gln Ala Leu Ser Glu Pro Ala Val Val Gln Lys Arg Ala Ser Gly Gln
                 245                 250                 255    





      <210> 445
      <211> 1178
      <212> PRT
      <213> Homo sapiens


      <400> 445
 Met Gly Leu Ala Gln Glu Ala Gln Arg Gln Glu Val Leu Gln Gln Val
   1               5                  10                  15    
 Leu Arg Leu Gln Val Arg Glu Glu Gly Arg Ser Leu Gln Leu Leu Ser
              20                  25                  30        
 Gln Glu Thr His Gly Thr Arg His Ile Pro Gly Ala His Lys His Thr
          35                  40                  45            
 Val Phe His Asp Thr Leu Ala Cys Arg Cys Ser Gln Lys Thr Ala Val
      50                  55                  60                
 Pro His Gln His Pro Asp Thr Glu Thr Cys Arg Ser Leu Asp Thr Trp
  65                  70                  75                  80
 Ile Leu Lys Ser Arg His Ile Val Pro Ser Pro Val Leu Ser Val Pro
                  85                  90                  95    
 Arg His Leu Gln Thr Thr Gln Pro Thr Pro Asp Pro Ser Ala Pro Cys
             100                 105                 110        
 Leu Gln Lys Pro Lys Leu Trp Gly Arg Glu Gly Pro Gly Thr Gly Ser
         115                 120                 125            
 Glu Pro Leu Pro Pro Glu Leu Gly Lys Gly Asp Pro Met Glu Cys Ile
     130                 135                 140                
 Thr Phe Gly Ile Ile Phe Ala Ala Val Gly Leu Arg Thr Leu Trp Ser
 145                 150                 155                 160
 Cys Val His Cys Arg Ala Ala Cys Trp Glu Gly Gly Leu Glu Val Glu
                 165                 170                 175    
 Met Thr Asp Pro Phe Cys Val Gly Gly Arg Arg Leu Pro Gly Ser Ser
             180                 185                 190        
 Lys Ser Gly Pro Gly Lys Asp Gly Ser Arg Lys Glu Val Arg Leu Pro
         195                 200                 205            
 Met Leu His Asp Pro Pro Lys Met Gly Met Pro Val Val Arg Gly Gly
     210                 215                 220                
 Gln Thr Val Pro Gly Gln Ala Pro Leu Cys Phe Asp Pro Gly Ser Pro
 225                 230                 235                 240
 Ala Ser Asp Lys Thr Glu Gly Lys Lys Lys Gly Arg Pro Lys Ala Glu
                 245                 250                 255    
 Asn Gln Ala Leu Arg Asp Ile Pro Leu Ser Leu Met Asn Asp Trp Lys
             260                 265                 270        
 Asp Glu Phe Lys Ala His Ser Arg Val Lys Cys Pro Asn Ser Gly Cys
         275                 280                 285            
 Trp Leu Glu Phe Pro Ser Ile Tyr Gly Leu Lys Tyr His Tyr Gln Arg
     290                 295                 300                
 Cys Gln Gly Gly Ala Ile Ser Asp Arg Leu Ala Phe Pro Cys Pro Phe
 305                 310                 315                 320
 Cys Glu Ala Ala Phe Thr Ser Lys Thr Gln Leu Glu Lys His Arg Ile
                 325                 330                 335    
 Trp Asn His Met Asp Arg Pro Leu Pro Ala Ser Lys Pro Gly Pro Ile
             340                 345                 350        
 Ser Arg Pro Val Thr Ile Ser Arg Pro Val Gly Val Ser Lys Pro Ile
         355                 360                 365            
 Gly Val Ser Lys Pro Val Thr Ile Gly Lys Pro Val Gly Val Ser Lys
     370                 375                 380                
 Pro Ile Gly Ile Ser Lys Pro Val Ser Val Gly Arg Pro Met Pro Val
 385                 390                 395                 400
 Thr Lys Ala Ile Pro Val Thr Arg Pro Val Pro Val Thr Lys Pro Val
                 405                 410                 415    
 Thr Val Ser Arg Pro Met Pro Val Thr Lys Ala Met Pro Val Thr Lys
             420                 425                 430        
 Pro Ile Thr Val Thr Lys Ser Val Pro Val Thr Lys Pro Val Pro Val
         435                 440                 445            
 Thr Lys Pro Ile Thr Val Thr Lys Leu Val Thr Val Thr Lys Pro Val
     450                 455                 460                
 Pro Val Thr Lys Pro Val Thr Val Ser Arg Pro Ile Val Val Ser Lys
 465                 470                 475                 480
 Pro Val Thr Val Ser Arg Pro Ile Ala Ile Ser Arg His Thr Pro Pro
                 485                 490                 495    
 Cys Lys Met Val Leu Leu Thr Arg Ser Glu Asn Lys Ala Pro Arg Ala
             500                 505                 510        
 Thr Gly Arg Asn Ser Gly Lys Lys Arg Ala Ala Asp Ser Leu Asp Thr
         515                 520                 525            
 Cys Pro Ile Pro Pro Lys Gln Ala Arg Pro Glu Asn Gly Glu Tyr Gly
     530                 535                 540                
 Pro Ser Ser Met Gly Gln Ser Ser Ala Phe Gln Leu Ser Ala Asp Thr
 545                 550                 555                 560
 Ser Ser Gly Ser Leu Ser Pro Gly Ser Arg Pro Ser Gly Gly Met Glu
                 565                 570                 575    
 Ala Leu Lys Ala Ala Gly Pro Ala Ser Pro Pro Glu Glu Asp Pro Glu
             580                 585                 590        
 Arg Thr Lys His Ser Leu Val Lys Ala Glu Asp Lys Ala Arg Val His
         595                 600                 605            
 Arg Ser Lys Lys Gln Glu Gly Pro Gly Pro Glu Asp Ala Arg Lys Lys
     610                 615                 620                
 Val Pro Ala Ala Pro Ile Thr Val Ser Lys Glu Ala Pro Ala Pro Val
 625                 630                 635                 640
 Ala His Pro Ala Pro Gly Gly Pro Glu Glu Gln Trp Gln Arg Ala Ile
                 645                 650                 655    
 His Glu Arg Gly Glu Ala Val Cys Pro Thr Cys Asn Val Val Thr Arg
             660                 665                 670        
 Lys Thr Leu Val Gly Leu Lys Lys His Met Glu Val Cys Gln Lys Leu
         675                 680                 685            
 Gln Asp Ala Leu Lys Cys Gln His Cys Arg Lys Gln Phe Lys Ser Lys
     690                 695                 700                
 Ala Gly Leu Asn Tyr His Thr Met Ala Glu His Ser Ala Lys Pro Ser
 705                 710                 715                 720
 Asp Ala Glu Ala Ser Glu Gly Gly Glu Gln Glu Glu Arg Glu Arg Leu
                 725                 730                 735    
 Arg Lys Val Leu Lys Gln Met Gly Arg Leu Arg Cys Pro Gln Glu Gly
             740                 745                 750        
 Cys Gly Ala Ala Phe Ser Ser Leu Met Gly Tyr Gln Tyr His Gln Arg
         755                 760                 765            
 Arg Cys Gly Lys Pro Pro Cys Glu Val Asp Ser Pro Ser Phe Pro Cys
     770                 775                 780                
 Thr His Cys Gly Lys Thr Tyr Arg Ser Lys Ala Gly His Asp Tyr His
 785                 790                 795                 800
 Val Arg Ser Glu His Thr Ala Pro Pro Pro Glu Glu Pro Thr Asp Lys
                 805                 810                 815    
 Ser Pro Glu Ala Glu Asp Pro Leu Gly Val Glu Arg Thr Pro Ser Gly
             820                 825                 830        
 Arg Val Arg Arg Thr Ser Ala Gln Val Ala Val Phe His Leu Gln Glu
         835                 840                 845            
 Ile Ala Glu Asp Glu Leu Ala Arg Asp Trp Thr Lys Arg Arg Met Lys
     850                 855                 860                
 Asp Asp Leu Val Pro Glu Thr Ala Arg Leu Asn Tyr Thr Arg Pro Gly
 865                 870                 875                 880
 Leu Pro Thr Leu Asn Pro Gln Leu Leu Glu Ala Trp Lys Asn Glu Val
                 885                 890                 895    
 Lys Glu Lys Gly His Val Asn Cys Pro Asn Asp Val Ser Gly Gly Ser
             900                 905                 910        
 Arg Cys Cys Glu Ala Ile Tyr Ser Ser Val Ser Gly Leu Lys Ala His
         915                 920                 925            
 Leu Ala Ser Cys Ser Lys Gly Ala His Leu Ala Gly Lys Tyr Arg Cys
     930                 935                 940                
 Leu Leu Cys Pro Lys Glu Phe Ser Ser Glu Ser Gly Val Lys Tyr His
 945                 950                 955                 960
 Ile Leu Lys Thr His Ala Glu Pro Pro Ala Ala Leu Leu Gln Val Leu
                 965                 970                 975    
 Ala Trp Ser Arg Arg Leu Cys Pro Ala Leu Leu Gln Val Leu Ala Trp
             980                 985                 990        
 Ser Arg Arg Leu Cys Pro Ala Pro Cys Arg Cys Leu Pro Gly Pro Glu
         995                1000                1005            
 Gly Cys Val Gln Pro Pro Ala Ala Gly Ala Cys Leu Val Leu Lys Ala
    1010                1015                1020                
 Val Ser Ser Pro Leu Leu Gln Ala Val Ser Ser Pro Ala Ala Gly Ala
1025                1030                1035                1040
 Cys Leu Val Leu Lys Ala Val Ser Ser Pro Ala Ala Gly Ala Cys Leu
                1045                1050                1055    
 Val Leu Lys Ala Val Ser Ser Pro Ala Ala Gly Ala Cys Leu Val Leu
            1060                1065                1070        
 Lys Ala Val Ser Ser Pro Ala Ala Gly Ala Cys Leu Val Leu Lys Ala
        1075                1080                1085            
 Val Ser Ser Pro Leu Leu Gln Asn Trp Phe Arg Thr Ser Ala Asp Pro
    1090                1095                1100                
 Pro Pro Lys His Arg Ser Gln Asp Ser Leu Val Pro Lys Lys Glu Lys
1105                1110                1115                1120
 Lys Lys Asn Leu Ala Gly Gly Lys Lys Arg Gly Arg Lys Pro Lys Glu
                1125                1130                1135    
 Arg Thr Pro Glu Glu Pro Val Ala Lys Leu Pro Pro Arg Arg Asp Asp
            1140                1145                1150        
 Trp Pro Pro Gly Cys Arg Asp Lys Gly Ala Arg Gly Ser Thr Gly Arg
        1155                1160                1165            
 Lys Val Gly Val Ser Lys Ala Pro Glu Lys
    1170                1175            



      <210> 446
      <211> 1172
      <212> PRT
      <213> Homo sapiens


      <400> 446
 Met Gly Leu Ala Gln Glu Ala Gln Arg Gln Glu Val Leu Gln Gln Val
   1               5                  10                  15    
 Leu Arg Leu Gln Val Arg Glu Glu Gly Arg Ser Leu Gln Leu Leu Ser
              20                  25                  30        
 Gln Glu Thr His Gly Thr Arg His Ile Pro Gly Ala His Lys His Thr
          35                  40                  45            
 Val Phe His Asp Thr Leu Ala Cys Arg Cys Ser Gln Lys Thr Ala Val
      50                  55                  60                
 Pro His Gln His Pro Asp Thr Glu Thr Cys Arg Ser Leu Asp Thr Trp
  65                  70                  75                  80
 Ile Leu Lys Ser Arg His Ile Val Pro Ser Pro Val Leu Ser Val Pro
                  85                  90                  95    
 Arg His Leu Gln Thr Thr Gln Pro Thr Pro Asp Pro Ser Ala Pro Cys
             100                 105                 110        
 Leu Gln Lys Pro Lys Leu Trp Gly Arg Glu Gly Pro Gly Thr Gly Ser
         115                 120                 125            
 Glu Pro Leu Pro Pro Glu Leu Gly Lys Gly Asp Pro Met Glu Cys Ile
     130                 135                 140                
 Thr Phe Gly Ile Ile Phe Ala Ala Val Gly Leu Arg Thr Leu Trp Ser
 145                 150                 155                 160
 Cys Val His Cys Arg Ala Ala Cys Trp Glu Gly Gly Leu Glu Val Glu
                 165                 170                 175    
 Met Thr Asp Pro Phe Cys Val Gly Gly Arg Arg Leu Pro Gly Ser Ser
             180                 185                 190        
 Lys Ser Gly Pro Gly Lys Asp Gly Ser Arg Lys Glu Val Arg Leu Pro
         195                 200                 205            
 Met Leu His Asp Pro Pro Lys Met Gly Met Pro Val Val Arg Gly Gly
     210                 215                 220                
 Gln Thr Val Pro Gly Gln Ala Pro Leu Cys Phe Asp Pro Gly Ser Pro
 225                 230                 235                 240
 Ala Ser Asp Lys Thr Glu Gly Lys Lys Lys Gly Arg Pro Lys Ala Glu
                 245                 250                 255    
 Asn Gln Ala Leu Arg Asp Ile Pro Leu Ser Leu Met Asn Asp Trp Lys
             260                 265                 270        
 Asp Glu Phe Lys Ala His Ser Arg Val Lys Cys Pro Asn Ser Gly Cys
         275                 280                 285            
 Trp Leu Glu Phe Pro Ser Ile Tyr Gly Leu Lys Tyr His Tyr Gln Arg
     290                 295                 300                
 Cys Gln Gly Gly Ala Ile Ser Asp Arg Leu Ala Phe Pro Cys Pro Phe
 305                 310                 315                 320
 Cys Glu Ala Ala Phe Thr Ser Lys Thr Gln Leu Glu Lys His Arg Ile
                 325                 330                 335    
 Trp Asn His Met Asp Arg Pro Leu Pro Ala Ser Lys Pro Gly Pro Ile
             340                 345                 350        
 Ser Arg Pro Val Thr Ile Ser Arg Pro Val Gly Val Ser Lys Pro Ile
         355                 360                 365            
 Gly Val Ser Lys Pro Val Thr Ile Gly Lys Pro Val Gly Val Ser Lys
     370                 375                 380                
 Pro Ile Gly Ile Ser Lys Pro Val Ser Val Gly Arg Pro Met Pro Val
 385                 390                 395                 400
 Thr Lys Ala Ile Pro Val Thr Arg Pro Val Pro Val Thr Lys Pro Val
                 405                 410                 415    
 Thr Val Ser Arg Pro Met Pro Val Thr Lys Ala Met Pro Val Thr Lys
             420                 425                 430        
 Pro Ile Thr Val Thr Lys Ser Val Pro Val Thr Lys Pro Val Pro Val
         435                 440                 445            
 Thr Lys Pro Ile Thr Val Thr Lys Leu Val Thr Val Thr Lys Pro Val
     450                 455                 460                
 Pro Val Thr Lys Pro Val Thr Val Ser Arg Pro Ile Val Val Ser Lys
 465                 470                 475                 480
 Pro Val Thr Val Ser Arg Pro Ile Ala Ile Ser Arg His Thr Pro Pro
                 485                 490                 495    
 Cys Lys Met Val Leu Leu Thr Arg Ser Glu Asn Lys Ala Pro Arg Ala
             500                 505                 510        
 Thr Gly Arg Asn Ser Gly Lys Lys Arg Ala Ala Asp Ser Leu Asp Thr
         515                 520                 525            
 Cys Pro Ile Pro Pro Lys Gln Ala Arg Pro Glu Asn Gly Glu Tyr Gly
     530                 535                 540                
 Pro Ser Ser Met Gly Gln Ser Ser Ala Phe Gln Leu Ser Ala Asp Thr
 545                 550                 555                 560
 Ser Ser Gly Ser Leu Ser Pro Gly Ser Arg Pro Ser Gly Gly Met Glu
                 565                 570                 575    
 Ala Leu Lys Ala Ala Gly Pro Ala Ser Pro Pro Glu Glu Asp Pro Glu
             580                 585                 590        
 Arg Thr Lys His Ser Leu Val Lys Ala Glu Asp Lys Ala Arg Val His
         595                 600                 605            
 Arg Ser Lys Lys Gln Glu Gly Pro Gly Pro Glu Asp Ala Arg Lys Lys
     610                 615                 620                
 Val Pro Ala Ala Pro Ile Thr Val Ser Lys Glu Ala Pro Ala Pro Val
 625                 630                 635                 640
 Ala His Pro Ala Pro Gly Gly Pro Glu Glu Gln Trp Gln Arg Ala Ile
                 645                 650                 655    
 His Glu Arg Gly Glu Ala Val Cys Pro Thr Cys Asn Val Val Thr Arg
             660                 665                 670        
 Lys Thr Leu Val Gly Leu Lys Lys His Met Glu Val Cys Gln Lys Leu
         675                 680                 685            
 Gln Asp Ala Leu Lys Cys Gln His Cys Arg Lys Gln Phe Lys Ser Lys
     690                 695                 700                
 Ala Gly Leu Asn Tyr His Thr Met Ala Glu His Ser Ala Lys Pro Ser
 705                 710                 715                 720
 Asp Ala Glu Ala Ser Glu Gly Gly Glu Gln Glu Glu Arg Glu Arg Leu
                 725                 730                 735    
 Arg Lys Val Leu Lys Gln Met Gly Arg Leu Arg Cys Pro Gln Glu Gly
             740                 745                 750        
 Cys Gly Ala Ala Phe Ser Ser Leu Met Gly Tyr Gln Tyr His Gln Arg
         755                 760                 765            
 Arg Cys Gly Lys Pro Pro Cys Glu Val Asp Ser Pro Ser Phe Pro Cys
     770                 775                 780                
 Thr His Cys Gly Lys Thr Tyr Arg Ser Lys Ala Gly His Asp Tyr His
 785                 790                 795                 800
 Val Arg Ser Glu His Thr Ala Pro Pro Pro Glu Glu Pro Thr Asp Lys
                 805                 810                 815    
 Ser Pro Glu Ala Glu Asp Pro Leu Gly Val Glu Arg Thr Pro Ser Gly
             820                 825                 830        
 Arg Val Arg Arg Thr Ser Ala Gln Val Ala Val Phe His Leu Gln Glu
         835                 840                 845            
 Ile Ala Glu Asp Glu Leu Ala Arg Asp Trp Thr Lys Arg Arg Met Lys
     850                 855                 860                
 Asp Asp Leu Val Pro Glu Thr Ala Arg Leu Asn Tyr Thr Arg Pro Gly
 865                 870                 875                 880
 Leu Pro Thr Leu Asn Pro Gln Leu Leu Glu Ala Trp Lys Asn Glu Val
                 885                 890                 895    
 Lys Glu Lys Gly His Val Asn Cys Pro Asn Asp Cys Cys Glu Ala Ile
             900                 905                 910        
 Tyr Ser Ser Val Ser Gly Leu Lys Ala His Leu Ala Ser Cys Ser Lys
         915                 920                 925            
 Gly Ala His Leu Ala Gly Lys Tyr Arg Cys Leu Leu Cys Pro Lys Glu
     930                 935                 940                
 Phe Ser Ser Glu Ser Gly Val Lys Tyr His Ile Leu Lys Thr His Ala
 945                 950                 955                 960
 Glu Pro Pro Ala Ala Leu Leu Gln Val Leu Ala Trp Ser Arg Arg Leu
                 965                 970                 975    
 Cys Pro Ala Leu Leu Gln Val Leu Ala Trp Ser Arg Arg Leu Cys Pro
             980                 985                 990        
 Ala Pro Cys Arg Cys Leu Pro Gly Pro Glu Gly Cys Val Gln Pro Pro
         995                1000                1005            
 Ala Ala Gly Ala Cys Leu Val Leu Lys Ala Val Ser Ser Pro Leu Leu
    1010                1015                1020                
 Gln Ala Val Ser Ser Pro Ala Ala Gly Ala Cys Leu Val Leu Lys Ala
1025                1030                1035                1040
 Val Ser Ser Pro Ala Ala Gly Ala Cys Leu Val Leu Lys Ala Val Ser
                1045                1050                1055    
 Ser Pro Ala Ala Gly Ala Cys Leu Val Leu Lys Ala Val Ser Ser Pro
            1060                1065                1070        
 Ala Ala Gly Ala Cys Leu Val Leu Lys Ala Val Ser Ser Pro Leu Leu
        1075                1080                1085            
 Gln Asn Trp Phe Arg Thr Ser Ala Asp Pro Pro Pro Lys His Arg Ser
    1090                1095                1100                
 Gln Asp Ser Leu Val Pro Lys Lys Glu Lys Lys Lys Asn Leu Ala Gly
1105                1110                1115                1120
 Gly Lys Lys Arg Gly Arg Lys Pro Lys Glu Arg Thr Pro Glu Glu Pro
                1125                1130                1135    
 Val Ala Lys Leu Pro Pro Arg Arg Asp Asp Trp Pro Pro Gly Cys Arg
            1140                1145                1150        
 Asp Lys Gly Ala Arg Gly Ser Thr Gly Arg Lys Val Gly Val Ser Lys
        1155                1160                1165            
 Ala Pro Glu Lys
    1170        



      <210> 447
      <211> 817
      <212> PRT
      <213> Homo sapiens


      <400> 447
 Met Met Gln Ser Gln Ser Arg Ser Cys Thr Glu Leu His Lys His Leu
   1               5                  10                  15    
 Thr Ser Ala Gln Cys Cys Leu Gln Asp Arg Gly Leu Gln Pro Pro Cys
              20                  25                  30        
 Leu Gln Ser Pro Arg Leu Pro Ala Lys Glu Asp Lys Glu Pro Gly Glu
          35                  40                  45            
 Asp Cys Pro Ser Pro Gln Pro Ala Pro Ala Ser Pro Arg Asp Ser Leu
      50                  55                  60                
 Ala Leu Gly Arg Ala Asp Pro Gly Ala Pro Val Ser Gln Glu Asp Met
  65                  70                  75                  80
 Gln Ala Met Val Gln Leu Ile Arg Tyr Met His Thr Tyr Cys Leu Pro
                  85                  90                  95    
 Gln Arg Lys Leu Pro Pro Gln Thr Pro Glu Pro Leu Pro Lys Ala Cys
             100                 105                 110        
 Ser Asn Pro Ser Gln Gln Val Arg Ser Arg Pro Trp Ser Arg His His
         115                 120                 125            
 Ser Lys Ala Ser Trp Ala Glu Phe Ser Ile Leu Arg Glu Leu Leu Ala
     130                 135                 140                
 Gln Asp Val Leu Cys Asp Val Ser Lys Pro Tyr Arg Leu Ala Thr Pro
 145                 150                 155                 160
 Val Tyr Ala Ser Leu Thr Pro Arg Ser Arg Pro Arg Pro Pro Lys Asp
                 165                 170                 175    
 Ser Gln Ala Ser Pro Gly Arg Pro Ser Ser Val Glu Glu Val Arg Ile
             180                 185                 190        
 Ala Ala Ser Pro Lys Ser Thr Gly Pro Arg Pro Ser Leu Arg Pro Leu
         195                 200                 205            
 Arg Leu Glu Val Lys Arg Glu Val Arg Arg Pro Ala Arg Leu Gln Gln
     210                 215                 220                
 Gln Glu Glu Glu Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu
 225                 230                 235                 240
 Lys Glu Glu Glu Glu Glu Trp Gly Arg Lys Arg Pro Gly Arg Gly Leu
                 245                 250                 255    
 Pro Trp Thr Lys Leu Gly Arg Lys Leu Glu Ser Ser Val Cys Pro Val
             260                 265                 270        
 Arg Arg Ser Arg Arg Leu Asn Pro Glu Leu Gly Pro Trp Leu Thr Phe
         275                 280                 285            
 Ala Asp Glu Pro Leu Val Pro Ser Glu Pro Gln Gly Ala Leu Pro Ser
     290                 295                 300                
 Leu Cys Leu Ala Pro Lys Ala Tyr Asp Val Glu Arg Glu Leu Gly Ser
 305                 310                 315                 320
 Pro Thr Asp Glu Asp Ser Gly Gln Asp Gln Gln Leu Leu Arg Gly Pro
                 325                 330                 335    
 Gln Ile Pro Ala Leu Glu Ser Pro Cys Glu Ser Gly Asp Pro Thr Phe
             340                 345                 350        
 Gly Lys Lys Ser Phe Glu Gln Thr Leu Thr Val Glu Leu Cys Gly Thr
         355                 360                 365            
 Ala Gly Glu Pro Gly Gly Phe His Trp Gln Val Pro Ser Gly Lys His
     370                 375                 380                
 Pro Cys Ile Ser Glu Phe Phe Ile Met His Gly Gln Gly Leu Thr Pro
 385                 390                 395                 400
 Pro Thr Thr Pro Pro Tyr Lys Pro Thr Glu Glu Asp Pro Phe Lys Pro
                 405                 410                 415    
 Asp Ile Lys His Ser Leu Gly Lys Glu Ile Ala Leu Ser Leu Pro Ser
             420                 425                 430        
 Pro Glu Gly Leu Ser Leu Lys Ala Thr Pro Gly Ala Ala His Lys Leu
         435                 440                 445            
 Pro Lys Lys His Pro Glu Arg Ser Glu Leu Leu Ser His Leu Arg His
     450                 455                 460                
 Ala Thr Ala Gln Pro Ala Ser Gln Ala Gly Gln Lys Arg Pro Phe Ser
 465                 470                 475                 480
 Cys Ser Phe Gly Asp His Asp Tyr Cys Gln Val Leu Arg Pro Glu Gly
                 485                 490                 495    
 Val Leu Gln Arg Lys Val Leu Arg Ser Trp Glu Pro Ser Gly Val His
             500                 505                 510        
 Leu Glu Asp Trp Pro Gln Gln Gly Ala Pro Trp Ala Glu Ala Gln Ala
         515                 520                 525            
 Pro Gly Arg Glu Glu Asp Arg Ser Cys Asp Ala Gly Ala Pro Pro Lys
     530                 535                 540                
 Asp Ser Thr Leu Leu Arg Asp His Glu Ile Arg Ala Ser Leu Thr Lys
 545                 550                 555                 560
 His Phe Gly Leu Leu Glu Thr Ala Leu Glu Glu Glu Asp Leu Ala Ser
                 565                 570                 575    
 Cys Lys Ser Pro Glu Tyr Asp Thr Val Phe Glu Asp Ser Ser Ser Ser
             580                 585                 590        
 Ser Gly Glu Ser Ser Phe Leu Pro Glu Glu Glu Glu Glu Glu Gly Glu
         595                 600                 605            
 Glu Glu Glu Glu Asp Asp Glu Glu Glu Asp Ser Gly Val Ser Pro Thr
     610                 615                 620                
 Cys Ser Asp His Cys Pro Tyr Gln Ser Pro Pro Ser Lys Ala Asn Arg
 625                 630                 635                 640
 Gln Leu Cys Ser Arg Ser Arg Ser Ser Ser Gly Ser Ser Pro Cys His
                 645                 650                 655    
 Ser Trp Ser Pro Ala Thr Arg Arg Asn Phe Arg Cys Glu Ser Arg Gly
             660                 665                 670        
 Pro Cys Ser Asp Arg Thr Pro Ser Ile Arg His Ala Arg Lys Arg Arg
         675                 680                 685            
 Glu Lys Ala Ile Gly Glu Gly Arg Val Val Tyr Ile Gln Asn Leu Ser
     690                 695                 700                
 Ser Asp Met Ser Ser Arg Glu Leu Lys Arg Arg Phe Glu Val Phe Gly
 705                 710                 715                 720
 Glu Ile Glu Glu Cys Glu Val Leu Thr Arg Asn Arg Arg Gly Glu Lys
                 725                 730                 735    
 Tyr Gly Phe Ile Thr Tyr Arg Cys Ser Glu His Ala Ala Leu Ser Leu
             740                 745                 750        
 Thr Lys Gly Ala Ala Leu Arg Lys Arg Asn Glu Pro Ser Phe Gln Leu
         755                 760                 765            
 Ser Tyr Gly Gly Leu Arg His Phe Cys Trp Pro Arg Tyr Thr Asp Tyr
     770                 775                 780                
 Asp Ser Asn Ser Glu Glu Ala Leu Pro Ala Ser Gly Lys Ser Lys Tyr
 785                 790                 795                 800
 Glu Ala Met Asp Phe Asp Ser Leu Leu Lys Glu Ala Gln Gln Ser Leu
                 805                 810                 815    
 His
    



      <210> 448
      <211> 145
      <212> PRT
      <213> Homo sapiens


      <400> 448
 Met Met Gly Ile Cys Pro Ser Cys Val Leu Trp Gly Met Lys Ser Cys
   1               5                  10                  15    
 Ser Ser Cys Ser Phe Pro Phe Pro Leu Arg Gly Gly Gly Trp Gly Cys
              20                  25                  30        
 Gln Gly Ser Thr Leu Gly Gly Gly Cys Trp Gly Cys Gln Gly Ser Thr
          35                  40                  45            
 Leu Cys Ser Leu Gly Arg Gly Lys Glu Ala Pro Pro Cys Met Leu Cys
      50                  55                  60                
 Arg Gly Pro Cys Arg Pro Leu Cys Leu Arg Gly Arg Arg Arg Gly Pro
  65                  70                  75                  80
 Leu Gly Lys Cys Ala His Thr His Thr His Thr His Thr Arg Thr Cys
                  85                  90                  95    
 Thr His Ala Arg Met His Thr His Thr His Ile Cys Ala Gly Val Gln
             100                 105                 110        
 Pro Lys Ser Gly Glu Pro Gly Leu Gly Ala Gln Leu Gly Leu Pro His
         115                 120                 125            
 Ser Trp Ser Pro Gln Gly Met Ser Leu Arg Ile His Phe Val Pro Cys
     130                 135                 140                
 Phe
 145



      <210> 449
      <211> 622
      <212> PRT
      <213> Homo sapiens


      <400> 449
 Met Glu Gly Pro Gly Leu Gly Ser Gln Cys Arg Asn His Ser His Gly
   1               5                  10                  15    
 Pro His Pro Pro Gly Phe Gly Arg Tyr Gly Ile Cys Ala His Glu Asn
              20                  25                  30        
 Lys Glu Leu Ala Asn Ala Arg Glu Ala Leu Pro Leu Ile Glu Asp Ser
          35                  40                  45            
 Ser Asn Cys Asp Ile Val Lys Ala Thr Gln Tyr Gly Ile Phe Glu Arg
      50                  55                  60                
 Cys Lys Glu Leu Val Glu Ala Gly Tyr Asp Val Arg Gln Pro Asp Lys
  65                  70                  75                  80
 Glu Asn Val Ser Leu Leu His Trp Ala Ala Ile Asn Asn Arg Leu Asp
                  85                  90                  95    
 Leu Val Arg Phe Tyr Ile Ser Lys Gly Ala Val Val Asp Gln Leu Gly
             100                 105                 110        
 Gly Asp Leu Asn Ser Thr Pro Leu His Trp Ala Ile Arg Gln Gly His
         115                 120                 125            
 Leu Pro Met Val Ile Leu Leu Leu Gln His Gly Ala Asp Pro Thr Leu
     130                 135                 140                
 Ile Asp Gly Glu Gly Phe Ser Ser Ile His Leu Ala Val Leu Phe Gln
 145                 150                 155                 160
 His Met Pro Ile Ile Ala Tyr Leu Ile Ser Lys Gly Gln Ser Val Asn
                 165                 170                 175    
 Met Thr Asp Val Asn Gly Gln Thr Pro Leu Met Leu Ser Ala His Lys
             180                 185                 190        
 Val Ile Gly Pro Glu Pro Thr Gly Phe Leu Leu Lys Phe Asn Pro Ser
         195                 200                 205            
 Leu Asn Val Val Asp Lys Ile His Gln Asn Thr Pro Leu His Trp Ala
     210                 215                 220                
 Val Ala Ala Gly Asn Val Asn Ala Val Asp Lys Leu Leu Glu Ala Gly
 225                 230                 235                 240
 Ser Ser Leu Asp Ile Gln Asn Val Lys Gly Glu Thr Pro Leu Asp Met
                 245                 250                 255    
 Ala Leu Gln Asn Lys Asn Gln Leu Ile Ile His Met Leu Lys Thr Glu
             260                 265                 270        
 Ala Lys Met Arg Ala Asn Gln Lys Phe Arg Leu Trp Arg Trp Leu Gln
         275                 280                 285            
 Lys Cys Glu Leu Phe Leu Leu Leu Met Leu Ser Val Ile Thr Met Trp
     290                 295                 300                
 Ala Ile Gly Tyr Ile Leu Asp Phe Asn Ser Asp Ser Trp Leu Leu Lys
 305                 310                 315                 320
 Gly Cys Leu Leu Val Thr Leu Phe Phe Leu Thr Ser Leu Phe Pro Arg
                 325                 330                 335    
 Phe Leu Val Gly Tyr Lys Asn Leu Val Tyr Leu Pro Thr Ala Phe Leu
             340                 345                 350        
 Leu Ser Ser Val Phe Trp Ile Phe Met Thr Trp Phe Ile Leu Phe Phe
         355                 360                 365            
 Pro Asp Leu Ala Gly Ala Pro Phe Tyr Phe Ser Phe Ile Phe Ser Ile
     370                 375                 380                
 Val Ala Phe Leu Tyr Phe Phe Tyr Lys Thr Trp Ala Thr Asp Pro Gly
 385                 390                 395                 400
 Phe Thr Lys Ala Ser Glu Glu Glu Lys Lys Val Asn Ile Ile Thr Leu
                 405                 410                 415    
 Ala Glu Thr Gly Ser Leu Asp Phe Arg Thr Phe Cys Thr Ser Cys Leu
             420                 425                 430        
 Ile Arg Lys Pro Leu Arg Ser Leu His Cys His Val Cys Asn Cys Cys
         435                 440                 445            
 Val Ala Arg Tyr Asp Gln His Cys Leu Trp Thr Gly Arg Cys Ile Gly
     450                 455                 460                
 Phe Gly Asn His His Tyr Tyr Ile Phe Phe Leu Phe Phe Leu Ser Met
 465                 470                 475                 480
 Val Cys Gly Trp Ile Ile Tyr Gly Ser Phe Ile Tyr Leu Ser Ser His
                 485                 490                 495    
 Cys Ala Thr Thr Phe Lys Glu Asp Gly Leu Trp Thr Tyr Leu Asn Gln
             500                 505                 510        
 Ile Val Ala Cys Ser Pro Trp Val Leu Tyr Ile Leu Met Leu Ala Thr
         515                 520                 525            
 Phe His Phe Ser Trp Ser Thr Phe Leu Leu Leu Asn Gln Leu Phe Gln
     530                 535                 540                
 Ile Ala Phe Leu Gly Leu Thr Ser His Glu Arg Ile Ser Leu Gln Lys
 545                 550                 555                 560
 Gln Ser Lys His Met Lys Gln Thr Leu Ser Leu Arg Lys Thr Pro Tyr
                 565                 570                 575    
 Asn Leu Gly Phe Met Gln Asn Leu Ala Asp Phe Phe Gln Cys Gly Cys
             580                 585                 590        
 Phe Gly Leu Val Lys Pro Cys Val Val Asp Trp Thr Ser Gln Tyr Thr
         595                 600                 605            
 Met Val Phe His Pro Ala Arg Glu Lys Val Leu Arg Ser Val
     610                 615                 620        



      <210> 450
      <211> 324
      <212> PRT
      <213> Homo sapiens


      <400> 450
 Met Ser Asp Ser Asp Leu Gly Glu Asp Glu Gly Leu Leu Ser Leu Ala
   1               5                  10                  15    
 Gly Lys Arg Lys Arg Arg Gly Asn Leu Pro Lys Glu Ser Val Lys Ile
              20                  25                  30        
 Leu Arg Asp Trp Leu Tyr Leu His Arg Tyr Asn Ala Tyr Pro Ser Glu
          35                  40                  45            
 Gln Glu Lys Leu Ser Leu Ser Gly Gln Thr Asn Leu Ser Val Leu Gln
      50                  55                  60                
 Ile Cys Asn Trp Phe Ile Asn Ala Arg Arg Arg Leu Leu Pro Asp Met
  65                  70                  75                  80
 Leu Arg Lys Asp Gly Lys Asp Pro Asn Gln Phe Thr Ile Ser Arg Arg
                  85                  90                  95    
 Gly Gly Lys Ala Ser Asp Val Ala Leu Pro Arg Gly Ser Ser Pro Ser
             100                 105                 110        
 Val Leu Ala Val Ser Val Pro Ala Pro Thr Asn Val Leu Ser Leu Ser
         115                 120                 125            
 Val Cys Ser Met Pro Leu His Ser Gly Gln Gly Glu Lys Pro Ala Ala
     130                 135                 140                
 Pro Phe Pro Arg Gly Glu Leu Glu Ser Pro Lys Pro Leu Val Thr Pro
 145                 150                 155                 160
 Gly Ser Thr Leu Thr Leu Leu Thr Arg Ala Glu Ala Gly Ser Pro Thr
                 165                 170                 175    
 Gly Gly Leu Phe Asn Thr Pro Pro Pro Thr Pro Pro Glu Gln Asp Lys
             180                 185                 190        
 Glu Asp Phe Ser Ser Phe Gln Leu Leu Val Glu Val Ala Leu Gln Arg
         195                 200                 205            
 Ala Ala Glu Met Glu Leu Gln Lys Gln Gln Asp Pro Ser Leu Pro Leu
     210                 215                 220                
 Leu His Thr Pro Ile Pro Leu Val Ser Glu Asn Pro Gln Pro Pro Leu
 225                 230                 235                 240
 Ser Asp Glu Thr Lys Arg Ser Glu Thr Ser Met Val Leu Leu Leu Leu
                 245                 250                 255    
 Leu Leu Leu Gln Lys Ile Pro Gly Thr Pro Leu Phe Gln Pro Gly Phe
             260                 265                 270        
 Leu Gly Trp Ala Gln Glu Ser Cys Gln Ile Gln Ser Tyr Val Gly Ser
         275                 280                 285            
 Lys Leu Pro Leu Cys Cys Phe Cys Gln Ala Arg Cys Gly His Ser Lys
     290                 295                 300                
 Phe Ile Cys Val Asn Lys Arg Lys Glu Glu Pro Ser Gly Cys Asn Arg
 305                 310                 315                 320
 Thr Asp Ser Ser
                



      <210> 451
      <211> 305
      <212> PRT
      <213> Homo sapiens


      <400> 451
 Met Gly Ile Gln Thr Ser Pro Val Leu Leu Ala Ser Leu Gly Val Gly
   1               5                  10                  15    
 Leu Val Thr Leu Leu Gly Leu Ala Val Gly Ser Tyr Leu Val Arg Arg
              20                  25                  30        
 Ser Arg Arg Pro Gln Val Thr Leu Leu Asp Pro Asn Glu Lys Tyr Leu
          35                  40                  45            
 Leu Arg Leu Leu Asp Lys Thr Thr Val Ser His Asn Thr Lys Arg Phe
      50                  55                  60                
 Arg Phe Ala Leu Pro Thr Ala His His Thr Leu Gly Leu Pro Val Gly
  65                  70                  75                  80
 Lys His Ile Tyr Leu Ser Thr Arg Ile Asp Gly Ser Leu Val Ile Arg
                  85                  90                  95    
 Pro Tyr Thr Pro Val Thr Ser Asp Glu Asp Gln Gly Tyr Val Asp Leu
             100                 105                 110        
 Val Ile Lys Val Tyr Leu Lys Gly Val His Pro Lys Phe Pro Glu Gly
         115                 120                 125            
 Gly Lys Met Ser Gln Tyr Leu Asp Ser Leu Lys Val Gly Asp Val Val
     130                 135                 140                
 Glu Phe Arg Gly Pro Ser Gly Leu Leu Thr Tyr Thr Gly Lys Gly His
 145                 150                 155                 160
 Phe Asn Ile Gln Pro Asn Lys Lys Ser Pro Pro Glu Pro Arg Val Ala
                 165                 170                 175    
 Lys Lys Leu Gly Met Ile Ala Gly Gly Thr Gly Ile Thr Pro Met Leu
             180                 185                 190        
 Gln Leu Ile Arg Ala Ile Leu Lys Val Pro Glu Asp Pro Thr Gln Cys
         195                 200                 205            
 Phe Leu Leu Phe Ala Asn Gln Thr Glu Lys Asp Ile Ile Leu Arg Glu
     210                 215                 220                
 Asp Leu Glu Glu Leu Gln Ala Arg Tyr Pro Asn Arg Phe Lys Leu Trp
 225                 230                 235                 240
 Phe Thr Leu Asp His Pro Pro Lys Asp Trp Ala Tyr Ser Lys Gly Phe
                 245                 250                 255    
 Val Thr Ala Asp Met Ile Arg Glu His Leu Pro Ala Pro Gly Asp Asp
             260                 265                 270        
 Val Leu Val Leu Leu Cys Gly Pro Pro Pro Met Val Gln Leu Ala Cys
         275                 280                 285            
 His Pro Asn Leu Asp Lys Leu Gly Tyr Ser Gln Lys Met Arg Phe Thr
     290                 295                 300                
 Tyr
 305



      <210> 452
      <211> 199
      <212> PRT
      <213> Homo sapiens


      <400> 452
 Met Phe Ser Leu Pro Leu Asn Cys Ser Pro Asp His Ile Arg Arg Gly
   1               5                  10                  15    
 Ser Cys Trp Gly Arg Pro Gln Asp Leu Lys Ile Ala Ala Pro Ala Trp
              20                  25                  30        
 Asn Ser Lys Cys His Pro Gly Ala Gly Ala Ala Met Ala Arg Gln His
          35                  40                  45            
 Ala Arg Thr Leu Trp Tyr Asp Arg Pro Met Tyr Val Phe Met Glu Phe
      50                  55                  60                
 Cys Val Glu Asp Ser Thr Asp Val His Val Leu Ile Glu Asp His Arg
  65                  70                  75                  80
 Ile Val Phe Ser Cys Lys Asn Ala Asp Gly Val Glu Leu Tyr Asn Glu
                  85                  90                  95    
 Ile Glu Phe Tyr Ala Lys Val Asn Ser Lys Asp Ser Gln Asp Lys Arg
             100                 105                 110        
 Ser Ser Arg Ser Ile Thr Cys Phe Val Arg Lys Trp Lys Glu Lys Val
         115                 120                 125            
 Ala Trp Pro Arg Leu Thr Lys Glu Asp Ile Lys Pro Val Trp Leu Ser
     130                 135                 140                
 Val Asp Phe Asp Asn Trp Arg Asp Trp Glu Gly Asp Glu Glu Met Glu
 145                 150                 155                 160
 Leu Ala His Val Glu His Tyr Ala Glu Leu Leu Lys Lys Val Ser Thr
                 165                 170                 175    
 Lys Arg Pro Pro Pro Ala Met Asp Asp Leu Asp Asp Asp Ser Asp Ser
             180                 185                 190        
 Ala Asp Asp Ala Thr Ser Asn
         195                



      <210> 453
      <211> 212
      <212> PRT
      <213> Homo sapiens


      <400> 453
 Met Glu Ala Lys Thr Leu Gly Thr Val Thr Pro Arg Lys Pro Val Leu
   1               5                  10                  15    
 Ser Val Ser Ala Arg Lys Ile Lys Asp Asn Ala Ala Asp Trp His Asn
              20                  25                  30        
 Leu Ile Leu Lys Trp Glu Thr Leu Asn Asp Ala Gly Phe Thr Thr Ala
          35                  40                  45            
 Asn Asn Ile Ala Asn Leu Lys Ile Ser Leu Leu Asn Lys Asp Lys Ile
      50                  55                  60                
 Glu Leu Asp Ser Ser Ser Pro Ala Ser Lys Glu Asn Glu Glu Lys Val
  65                  70                  75                  80
 Cys Leu Glu Tyr Asn Glu Glu Leu Glu Lys Leu Cys Glu Glu Leu Gln
                  85                  90                  95    
 Ala Thr Leu Asp Gly Leu Thr Lys Ile Gln Val Lys Met Glu Lys Leu
             100                 105                 110        
 Ser Ser Thr Thr Lys Gly Ile Cys Glu Leu Glu Asn Tyr His Tyr Gly
         115                 120                 125            
 Glu Glu Ser Lys Arg Pro Pro Leu Phe His Thr Trp Pro Thr Thr His
     130                 135                 140                
 Phe Tyr Glu Val Ser His Lys Leu Leu Glu Met Tyr Arg Lys Glu Leu
 145                 150                 155                 160
 Leu Leu Lys Arg Thr Val Ala Lys Glu Leu Ala His Thr Gly Asp Pro
                 165                 170                 175    
 Asp Leu Thr Leu Ser Tyr Leu Ser Met Trp Leu His Gln Pro Tyr Val
             180                 185                 190        
 Glu Ser Asp Ser Arg Leu His Leu Glu Ser Met Leu Leu Glu Thr Gly
         195                 200                 205            
 His Arg Ala Leu
     210        



      <210> 454
      <211> 403
      <212> PRT
      <213> Homo sapiens


      <400> 454
 Met Glu Pro Ala Gly Pro Cys Gly Phe Cys Pro Ala Gly Glu Val Gln
   1               5                  10                  15    
 Pro Ala Arg Tyr Thr Cys Pro Arg Cys Asn Ala Pro Tyr Cys Ser Leu
              20                  25                  30        
 Arg Cys Tyr Arg Thr His Gly Thr Cys Ala Glu Asn Phe Tyr Arg Asp
          35                  40                  45            
 Gln Val Leu Gly Glu Leu Arg Gly Cys Ser Ala Pro Pro Ser Arg Leu
      50                  55                  60                
 Ala Ser Ala Leu Arg Arg Leu Arg Gln Gln Arg Glu Thr Glu Asp Glu
  65                  70                  75                  80
 Pro Gly Glu Ala Gly Leu Ser Ser Gly Pro Ala Pro Gly Gly Leu Ser
                  85                  90                  95    
 Gly Leu Trp Glu Arg Leu Ala Pro Gly Glu Lys Ala Ala Phe Glu Arg
             100                 105                 110        
 Leu Leu Ser Arg Gly Glu Ala Gly Arg Leu Leu Pro Pro Trp Arg Pro
         115                 120                 125            
 Trp Trp Trp Asn Arg Gly Ala Gly Pro Gln Leu Leu Glu Glu Leu Asp
     130                 135                 140                
 Asn Ala Pro Gly Ser Asp Ala Ala Glu Leu Glu Leu Ala Pro Ala Arg
 145                 150                 155                 160
 Thr Pro Pro Asp Ser Val Lys Asp Ala Ser Ala Ala Glu Pro Ala Ala
                 165                 170                 175    
 Ala Glu Arg Val Leu Gly Asp Val Pro Gly Ala Cys Thr Pro Val Val
             180                 185                 190        
 Pro Thr Arg Ile Pro Ala Ile Val Ser Leu Ser Arg Gly Pro Val Ser
         195                 200                 205            
 Pro Leu Val Arg Phe Gln Leu Pro Asn Val Leu Phe Ala Tyr Ala His
     210                 215                 220                
 Thr Leu Ala Leu Tyr His Gly Gly Asp Asp Ala Leu Leu Ser Asp Phe
 225                 230                 235                 240
 Cys Ala Thr Leu Leu Gly Val Ser Gly Ala Leu Gly Ala Gln Gln Val
                 245                 250                 255    
 Phe Ala Ser Ala Glu Glu Ala Leu Gln Ala Ala Ala His Val Leu Glu
             260                 265                 270        
 Ala Gly Glu His Pro Pro Gly Pro Leu Gly Thr Arg Gly Ala Met His
         275                 280                 285            
 Glu Val Ala Arg Ile Leu Leu Gly Glu Gly Pro Thr Asn Gln Lys Gly
     290                 295                 300                
 Tyr Thr Leu Ala Ala Leu Gly Asp Leu Ala Gln Thr Leu Gly Arg Ala
 305                 310                 315                 320
 Arg Lys Gln Ala Val Ala Arg Glu Glu Arg Asp His Leu Tyr Arg Ala
                 325                 330                 335    
 Arg Lys Lys Cys Gln Phe Leu Leu Ala Trp Thr Asn Glu Asn Glu Ala
             340                 345                 350        
 Ala Leu Thr Pro Leu Ala Leu Asp Cys Ala Arg Ala His Gln Ala His
         355                 360                 365            
 Ala Val Val Ala Glu Glu Val Ala Ala Leu Thr Gly Glu Leu Glu Arg
     370                 375                 380                
 Leu Trp Gly Gly Pro Val Pro Pro Ala Pro Arg Thr Leu Ile Glu Glu
 385                 390                 395                 400
 Leu Pro Ser
            



      <210> 455
      <211> 179
      <212> PRT
      <213> Homo sapiens


      <400> 455
 Met Ala Leu Arg Ser Gln Phe Trp Gly Phe Ser Val Cys Arg Asn Pro
   1               5                  10                  15    
 Gly Cys Arg Phe Ala Ala Leu Ser Thr Ser Ser Glu Pro Ala Ala Lys
              20                  25                  30        
 Pro Glu Val Asp Pro Val Glu Asn Glu Ala Val Ala Pro Glu Phe Thr
          35                  40                  45            
 Asn Arg Asn Pro Arg Asn Leu Glu Leu Leu Ser Val Ala Arg Lys Glu
      50                  55                  60                
 Arg Gly Trp Arg Thr Val Phe Pro Ser Arg Glu Phe Trp His Arg Leu
  65                  70                  75                  80
 Arg Val Ile Arg Thr Gln His His Val Glu Ala Leu Val Glu His Gln
                  85                  90                  95    
 Asn Gly Lys Val Val Val Ser Ala Ser Thr Arg Glu Trp Ala Ile Lys
             100                 105                 110        
 Lys His Leu Tyr Ser Thr Arg Asn Val Val Ala Cys Glu Ser Ile Gly
         115                 120                 125            
 Arg Val Leu Ala Gln Arg Cys Leu Glu Ala Gly Ile Asn Phe Met Val
     130                 135                 140                
 Tyr Gln Pro Thr Pro Trp Glu Ala Ala Ser Asp Ser Met Lys Arg Leu
 145                 150                 155                 160
 Gln Ser Ala Met Thr Glu Gly Gly Val Val Leu Arg Glu Pro Gln Arg
                 165                 170                 175    
 Ile Tyr Glu
            



      <210> 456
      <211> 451
      <212> PRT
      <213> Homo sapiens


      <400> 456
 Met Pro Arg Glu Ile Ile Thr Leu Gln Leu Gly Gln Cys Gly Asn Gln
   1               5                  10                  15    
 Ile Gly Phe Glu Phe Trp Lys Gln Leu Cys Ala Glu His Gly Ile Ser
              20                  25                  30        
 Pro Glu Gly Ile Val Glu Glu Phe Ala Thr Glu Gly Thr Asp Arg Lys
          35                  40                  45            
 Asp Val Phe Phe Tyr Gln Ala Asp Asp Glu His Tyr Ile Pro Arg Ala
      50                  55                  60                
 Val Leu Leu Asp Leu Glu Pro Arg Val Ile His Ser Ile Leu Asn Ser
  65                  70                  75                  80
 Pro Tyr Ala Lys Leu Tyr Asn Pro Glu Asn Ile Tyr Leu Ser Glu His
                  85                  90                  95    
 Gly Gly Gly Ala Gly Asn Asn Trp Ala Ser Gly Phe Ser Gln Gly Glu
             100                 105                 110        
 Lys Ile His Glu Asp Ile Phe Asp Ile Ile Asp Arg Glu Ala Asp Gly
         115                 120                 125            
 Ser Asp Ser Leu Glu Gly Phe Val Leu Cys His Ser Ile Ala Gly Gly
     130                 135                 140                
 Thr Gly Ser Gly Leu Gly Ser Tyr Leu Leu Glu Arg Leu Asn Asp Arg
 145                 150                 155                 160
 Tyr Pro Lys Lys Leu Val Gln Thr Tyr Ser Val Phe Pro Tyr Gln Asp
                 165                 170                 175    
 Glu Met Ser Asp Val Val Val Gln Pro Tyr Asn Ser Leu Leu Thr Leu
             180                 185                 190        
 Lys Arg Leu Thr Gln Asn Ala Asp Cys Val Val Val Leu Asp Asn Thr
         195                 200                 205            
 Ala Leu Asn Arg Ile Ala Thr Asp Arg Leu His Ile Gln Asn Pro Ser
     210                 215                 220                
 Phe Ser Gln Ile Asn Gln Leu Val Ser Thr Ile Met Ser Ala Ser Thr
 225                 230                 235                 240
 Thr Thr Leu Arg Tyr Pro Gly Tyr Met Asn Asn Asp Leu Ile Gly Leu
                 245                 250                 255    
 Ile Ala Ser Leu Ile Pro Thr Pro Arg Leu His Phe Leu Met Thr Gly
             260                 265                 270        
 Tyr Thr Pro Leu Thr Thr Asp Gln Ser Val Ala Ser Val Arg Lys Thr
         275                 280                 285            
 Thr Val Leu Asp Val Met Arg Arg Leu Leu Gln Pro Lys Asn Val Met
     290                 295                 300                
 Val Ser Thr Gly Arg Asp Arg Gln Thr Asn His Cys Tyr Ile Ala Ile
 305                 310                 315                 320
 Leu Asn Ile Ile Gln Gly Glu Val Asp Pro Thr Gln Val His Lys Ser
                 325                 330                 335    
 Leu Gln Arg Ile Arg Glu Arg Lys Leu Ala Asn Phe Ile Pro Trp Gly
             340                 345                 350        
 Pro Ala Ser Ile Gln Val Ala Leu Ser Arg Lys Ser Pro Tyr Leu Pro
         355                 360                 365            
 Ser Ala His Arg Val Ser Gly Leu Met Met Ala Asn His Thr Ser Ile
     370                 375                 380                
 Ser Ser Leu Phe Glu Ser Ser Cys Gln Gln Phe Asp Lys Leu Arg Lys
 385                 390                 395                 400
 Arg Asp Ala Phe Leu Glu Gln Phe Arg Lys Glu Asp Met Phe Lys Asp
                 405                 410                 415    
 Thr Phe Asp Glu Met Asp Arg Ser Arg Glu Val Val Gln Glu Leu Ile
             420                 425                 430        
 Asp Glu Tyr His Ala Ala Thr Gln Pro Asp Tyr Ile Ser Trp Gly Thr
         435                 440                 445            
 Gln Glu Gln
     450    



      <210> 457
      <211> 1823
      <212> PRT
      <213> Homo sapiens


      <400> 457
 Met Ala Leu Ser Ser Ala Trp Arg Ser Val Leu Pro Leu Trp Leu Leu
   1               5                  10                  15    
 Trp Ser Ala Ala Cys Ser Arg Ala Ala Ser Gly Asp Asp Asn Ala Phe
              20                  25                  30        
 Pro Phe Asp Ile Glu Gly Ser Ser Ala Val Gly Arg Gln Asp Pro Pro
          35                  40                  45            
 Glu Thr Ser Glu Pro Arg Val Ala Leu Gly Arg Leu Pro Pro Ala Ala
      50                  55                  60                
 Glu Lys Cys Asn Ala Gly Phe Phe His Thr Leu Ser Gly Glu Cys Val
  65                  70                  75                  80
 Pro Cys Asp Cys Asn Gly Asn Ser Asn Glu Cys Leu Asp Gly Ser Gly
                  85                  90                  95    
 Tyr Cys Val His Cys Gln Arg Asn Thr Thr Gly Glu His Cys Glu Lys
             100                 105                 110        
 Cys Leu Asp Gly Tyr Ile Gly Asp Ser Ile Arg Gly Ala Pro Gln Phe
         115                 120                 125            
 Cys Gln Pro Cys Pro Cys Pro Leu Pro His Leu Ala Asn Phe Ala Glu
     130                 135                 140                
 Ser Cys Tyr Arg Lys Asn Gly Ala Val Arg Cys Ile Cys Asn Glu Asn
 145                 150                 155                 160
 Tyr Ala Gly Pro Asn Cys Glu Arg Cys Ala Pro Gly Tyr Tyr Gly Asn
                 165                 170                 175    
 Pro Leu Leu Ile Gly Ser Thr Cys Lys Lys Cys Asp Cys Ser Gly Asn
             180                 185                 190        
 Ser Asp Pro Asn Leu Ile Phe Glu Asp Cys Asp Glu Val Thr Gly Gln
         195                 200                 205            
 Cys Arg Asn Cys Leu Arg Asn Thr Thr Gly Phe Lys Cys Glu Arg Cys
     210                 215                 220                
 Ala Pro Gly Tyr Tyr Gly Asp Ala Arg Ile Ala Lys Asn Cys Ala Val
 225                 230                 235                 240
 Cys Asn Cys Gly Gly Gly Pro Cys Asp Ser Val Thr Gly Glu Cys Leu
                 245                 250                 255    
 Glu Glu Gly Phe Glu Pro Pro Thr Gly Met Asp Cys Pro Thr Ile Ser
             260                 265                 270        
 Cys Asp Lys Cys Val Trp Asp Leu Thr Asp Ala Leu Arg Leu Ala Ala
         275                 280                 285            
 Leu Ser Ile Glu Glu Gly Lys Ser Gly Val Leu Ser Val Ser Ser Gly
     290                 295                 300                
 Ala Ala Ala His Arg His Val Asn Glu Ile Asn Ala Thr Ile Tyr Leu
 305                 310                 315                 320
 Leu Lys Thr Lys Leu Ser Glu Arg Glu Asn Gln Tyr Ala Leu Arg Lys
                 325                 330                 335    
 Ile Gln Ile Asn Asn Ala Glu Asn Thr Met Lys Ser Leu Leu Ser Asp
             340                 345                 350        
 Val Glu Glu Leu Val Glu Lys Glu Asn Gln Ala Ser Arg Lys Gly Gln
         355                 360                 365            
 Leu Val Gln Lys Glu Ser Met Asp Thr Ile Asn His Ala Ser Gln Leu
     370                 375                 380                
 Val Glu Gln Ala His Asp Met Arg Asp Lys Ile Gln Glu Ile Asn Asn
 385                 390                 395                 400
 Lys Met Leu Tyr Tyr Gly Glu Glu His Glu Leu Ser Pro Lys Glu Ile
                 405                 410                 415    
 Ser Glu Lys Leu Val Leu Ala Gln Lys Met Leu Glu Glu Ile Arg Ser
             420                 425                 430        
 Arg Gln Pro Phe Phe Thr Gln Arg Glu Leu Val Asp Glu Glu Ala Asp
         435                 440                 445            
 Glu Ala Tyr Glu Leu Leu Ser Gln Ala Glu Ser Trp Gln Arg Leu His
     450                 455                 460                
 Asn Glu Thr Arg Thr Leu Phe Pro Val Val Leu Glu Gln Leu Asp Asp
 465                 470                 475                 480
 Tyr Asn Ala Lys Leu Ser Asp Leu Gln Glu Ala Leu Asp Gln Ala Leu
                 485                 490                 495    
 Asn His Val Arg Asp Ala Glu Asp Met Asn Arg Ala Thr Ala Ala Arg
             500                 505                 510        
 Gln Arg Asp His Glu Lys Gln Gln Glu Arg Val Arg Glu Gln Met Glu
         515                 520                 525            
 Val Val Asn Met Ser Leu Ser Thr Ser Ala Asp Ser Leu Thr Thr Pro
     530                 535                 540                
 Arg Leu Thr Leu Ser Glu Leu Asp Asp Ile Ile Lys Asn Ala Ser Gly
 545                 550                 555                 560
 Ile Tyr Ala Glu Ile Asp Gly Ala Lys Ser Glu Leu Gln Val Lys Leu
                 565                 570                 575    
 Ser Asn Leu Ser Asn Leu Ser His Asp Leu Val Gln Glu Ala Ile Asp
             580                 585                 590        
 His Ala Gln Asp Leu Gln Gln Glu Ala Asn Glu Leu Ser Arg Lys Leu
         595                 600                 605            
 His Ser Ser Asp Met Asn Gly Leu Val Gln Lys Ala Leu Asp Ala Ser
     610                 615                 620                
 Asn Val Tyr Glu Asn Ile Val Asn Tyr Val Ser Glu Ala Asn Glu Thr
 625                 630                 635                 640
 Ala Glu Phe Ala Leu Asn Thr Thr Asp Arg Ile Tyr Asp Ala Val Ser
                 645                 650                 655    
 Gly Ile Asp Thr Gln Ile Ile Tyr His Lys Asp Glu Ser Glu Asn Leu
             660                 665                 670        
 Leu Asn Gln Ala Arg Glu Leu Gln Ala Lys Ala Glu Ser Ser Ser Asp
         675                 680                 685            
 Glu Ala Val Ala Asp Thr Ser Arg Arg Val Gly Gly Ala Leu Ala Arg
     690                 695                 700                
 Lys Ser Ala Leu Lys Thr Arg Leu Ser Asp Ala Val Lys Gln Leu Gln
 705                 710                 715                 720
 Ala Ala Glu Arg Gly Asp Ala Gln Gln Arg Leu Gly Gln Ser Arg Leu
                 725                 730                 735    
 Ile Thr Glu Glu Ala Asn Arg Thr Thr Met Glu Val Gln Gln Ala Thr
             740                 745                 750        
 Ala Pro Met Ala Asn Asn Leu Thr Asn Trp Ser Gln Asn Leu Gln His
         755                 760                 765            
 Phe Asp Ser Ser Ala Tyr Asn Thr Ala Val Asn Ser Ala Arg Asp Ala
     770                 775                 780                
 Val Arg Asn Leu Thr Glu Val Val Pro Gln Leu Leu Asp Gln Leu Arg
 785                 790                 795                 800
 Thr Val Glu Gln Lys Arg Pro Ala Ser Asn Val Ser Ala Ser Ile Gln
                 805                 810                 815    
 Arg Ile Arg Glu Leu Ile Ala Gln Thr Arg Ser Val Ala Ser Lys Ile
             820                 825                 830        
 Gln Val Ser Met Met Phe Asp Gly Gln Ser Ala Val Glu Val His Ser
         835                 840                 845            
 Arg Thr Ser Met Asp Asp Leu Lys Ala Phe Thr Ser Leu Ser Leu Tyr
     850                 855                 860                
 Met Lys Pro Pro Val Lys Arg Pro Glu Leu Thr Glu Thr Ala Asp Gln
 865                 870                 875                 880
 Phe Ile Leu Tyr Leu Gly Ser Lys Asn Ala Lys Lys Glu Tyr Met Gly
                 885                 890                 895    
 Leu Ala Ile Lys Asn Asp Asn Leu Val Tyr Val Tyr Asn Leu Gly Thr
             900                 905                 910        
 Lys Asp Val Glu Ile Pro Leu Asp Ser Lys Pro Val Ser Ser Trp Pro
         915                 920                 925            
 Ala Tyr Phe Ser Ile Val Lys Ile Glu Arg Val Gly Lys His Gly Lys
     930                 935                 940                
 Val Phe Leu Thr Val Pro Ser Leu Ser Ser Thr Ala Glu Glu Lys Phe
 945                 950                 955                 960
 Ile Lys Lys Gly Glu Phe Ser Gly Asp Asp Ser Leu Leu Asp Leu Asp
                 965                 970                 975    
 Pro Glu Asp Thr Val Phe Tyr Val Gly Gly Val Pro Ser Asn Phe Lys
             980                 985                 990        
 Leu Pro Thr Ser Leu Asn Leu Pro Gly Phe Val Gly Cys Leu Glu Leu
         995                1000                1005            
 Ala Thr Leu Asn Asn Asp Val Ile Ser Leu Tyr Asn Phe Lys His Ile
    1010                1015                1020                
 Tyr Asn Met Asp Pro Ser Thr Ser Val Pro Cys Ala Arg Asp Lys Leu
1025                1030                1035                1040
 Ala Phe Thr Gln Ser Arg Ala Ala Ser Tyr Phe Phe Asp Gly Ser Gly
                1045                1050                1055    
 Tyr Ala Val Val Arg Asp Ile Thr Arg Arg Gly Lys Phe Gly Gln Val
            1060                1065                1070        
 Thr Arg Phe Asp Ile Glu Val Arg Thr Pro Ala Asp Asn Gly Leu Ile
        1075                1080                1085            
 Leu Leu Met Val Asn Gly Ser Met Phe Phe Arg Leu Glu Met Arg Asn
    1090                1095                1100                
 Gly Tyr Leu His Val Phe Tyr Asp Phe Gly Phe Ser Ser Gly Pro Val
1105                1110                1115                1120
 His Leu Glu Asp Thr Leu Lys Lys Ala Gln Ile Asn Asp Ala Lys Tyr
                1125                1130                1135    
 His Glu Ile Ser Ile Ile Tyr His Asn Asp Lys Lys Met Ile Leu Val
            1140                1145                1150        
 Val Asp Arg Arg His Val Lys Ser Met Asp Asn Glu Lys Met Lys Ile
        1155                1160                1165            
 Pro Phe Thr Asp Ile Tyr Ile Gly Gly Ala Pro Pro Glu Ile Leu Gln
    1170                1175                1180                
 Ser Arg Ala Leu Arg Ala His Leu Pro Leu Asp Ile Asn Phe Arg Gly
1185                1190                1195                1200
 Cys Met Lys Gly Phe Gln Phe Gln Lys Lys Asp Phe Asn Leu Leu Glu
                1205                1210                1215    
 Gln Thr Glu Thr Leu Gly Val Gly Tyr Gly Cys Pro Glu Asp Ser Leu
            1220                1225                1230        
 Ile Ser Arg Arg Ala Tyr Phe Asn Gly Gln Ser Phe Ile Ala Ser Ile
        1235                1240                1245            
 Gln Lys Ile Ser Phe Phe Asp Gly Phe Glu Gly Gly Phe Asn Phe Arg
    1250                1255                1260                
 Thr Leu Gln Pro Asn Gly Leu Leu Phe Tyr Tyr Ala Ser Gly Ser Asp
1265                1270                1275                1280
 Val Phe Ser Ile Ser Leu Asp Asn Gly Thr Val Ile Met Asp Val Lys
                1285                1290                1295    
 Gly Ile Lys Val Gln Ser Val Asp Lys Gln Tyr Asn Asp Gly Leu Ser
            1300                1305                1310        
 His Phe Val Ile Ser Ser Val Ser Pro Thr Arg Tyr Glu Leu Ile Val
        1315                1320                1325            
 Asp Lys Ser Arg Val Gly Ser Lys Asn Pro Thr Lys Gly Lys Ile Glu
    1330                1335                1340                
 Gln Thr Gln Ala Ser Glu Lys Lys Phe Tyr Phe Gly Gly Ser Pro Ile
1345                1350                1355                1360
 Ser Ala Gln Tyr Ala Asn Phe Thr Gly Cys Ile Ser Asn Ala Tyr Phe
                1365                1370                1375    
 Thr Arg Val Asp Arg Asp Val Glu Val Glu Asp Phe Gln Arg Tyr Thr
            1380                1385                1390        
 Glu Lys Val His Thr Ser Leu Tyr Glu Cys Pro Ile Glu Ser Ser Pro
        1395                1400                1405            
 Leu Phe Leu Leu His Lys Lys Gly Lys Asn Leu Ser Lys Pro Lys Ala
    1410                1415                1420                
 Ser Gln Asn Lys Lys Gly Gly Lys Ser Lys Asp Ala Pro Ser Trp Asp
1425                1430                1435                1440
 Pro Val Ala Leu Lys Leu Pro Glu Arg Asn Thr Pro Arg Asn Ser His
                1445                1450                1455    
 Cys His Leu Ser Asn Ser Pro Arg Ala Ile Glu His Ala Tyr Gln Tyr
            1460                1465                1470        
 Gly Gly Thr Ala Asn Ser Arg Gln Glu Phe Glu His Leu Lys Gly Asp
        1475                1480                1485            
 Phe Gly Ala Lys Ser Gln Phe Ser Ile Arg Leu Arg Thr Arg Ser Ser
    1490                1495                1500                
 His Gly Met Ile Phe Tyr Val Ser Asp Gln Glu Glu Asn Asp Phe Met
1505                1510                1515                1520
 Thr Leu Phe Leu Ala His Gly Arg Leu Val Tyr Met Phe Asn Val Gly
                1525                1530                1535    
 His Lys Lys Leu Lys Ile Arg Ser Gln Glu Lys Tyr Asn Asp Gly Leu
            1540                1545                1550        
 Trp His Asp Val Ile Phe Ile Arg Glu Arg Ser Ser Gly Arg Leu Val
        1555                1560                1565            
 Ile Asp Gly Leu Arg Val Leu Glu Glu Ser Leu Pro Pro Thr Glu Ala
    1570                1575                1580                
 Thr Trp Lys Ile Lys Gly Pro Ile Tyr Leu Gly Gly Val Ala Pro Gly
1585                1590                1595                1600
 Lys Ala Val Lys Asn Val Gln Ile Asn Ser Ile Tyr Ser Phe Ser Gly
                1605                1610                1615    
 Cys Leu Ser Asn Leu Gln Leu Asn Gly Ala Ser Ile Thr Ser Ala Ser
            1620                1625                1630        
 Gln Thr Phe Ser Val Thr Pro Cys Phe Glu Gly Pro Met Glu Thr Gly
        1635                1640                1645            
 Thr Tyr Phe Ser Thr Glu Gly Gly Tyr Val Val Leu Asp Glu Ser Phe
    1650                1655                1660                
 Asn Ile Gly Leu Lys Phe Glu Ile Ala Phe Glu Val Arg Pro Arg Ser
1665                1670                1675                1680
 Ser Ser Gly Thr Leu Val His Gly His Ser Val Asn Gly Glu Tyr Leu
                1685                1690                1695    
 Asn Val His Met Lys Asn Gly Gln Val Ile Val Lys Val Asn Asn Gly
            1700                1705                1710        
 Ile Arg Asp Phe Ser Thr Ser Val Thr Pro Lys Gln Ser Leu Cys Asp
        1715                1720                1725            
 Gly Arg Trp His Arg Ile Thr Val Ile Arg Asp Ser Asn Val Val Gln
    1730                1735                1740                
 Leu Asp Val Asp Ser Glu Val Asn His Val Val Gly Pro Leu Asn Pro
1745                1750                1755                1760
 Lys Pro Ile Asp His Arg Glu Pro Val Phe Val Gly Gly Val Pro Glu
                1765                1770                1775    
 Ser Leu Leu Thr Pro Arg Leu Ala Pro Ser Lys Pro Phe Thr Gly Cys
            1780                1785                1790        
 Ile Arg His Phe Val Ile Asp Gly His Pro Val Ser Phe Ser Lys Ala
        1795                1800                1805            
 Ala Leu Val Ser Gly Ala Val Ser Ile Asn Ser Cys Pro Ala Ala
    1810                1815                1820            



      <210> 458
      <211> 327
      <212> PRT
      <213> Homo sapiens


      <400> 458
 Met Thr Leu Thr Cys Glu Thr Gln Leu Ser Pro Gln Arg Pro Asp Val
   1               5                  10                  15    
 Gln Leu Gln Phe Ser Leu Phe Arg Asp Ser Gln Thr Leu Gly Leu Gly
              20                  25                  30        
 Trp Ser Arg Ser Pro Arg Leu Gln Ile Pro Ala Met Trp Thr Glu Asp
          35                  40                  45            
 Ser Gly Ser Tyr Trp Cys Glu Val Glu Thr Val Thr His Ser Ile Lys
      50                  55                  60                
 Lys Arg Ser Leu Arg Ser Gln Ile Arg Val Gln Arg Val Pro Val Ser
  65                  70                  75                  80
 Asn Val Asn Leu Glu Ile Arg Pro Thr Gly Gly Gln Leu Ile Glu Gly
                  85                  90                  95    
 Glu Asn Met Val Leu Ile Cys Ser Val Ala Gln Gly Ser Gly Thr Val
             100                 105                 110        
 Thr Phe Ser Trp His Lys Glu Gly Arg Val Arg Ser Leu Gly Arg Lys
         115                 120                 125            
 Thr Gln Arg Ser Leu Leu Ala Glu Leu His Val Leu Thr Val Lys Glu
     130                 135                 140                
 Ser Asp Ala Gly Arg Tyr Tyr Cys Ala Ala Asp Asn Val His Ser Pro
 145                 150                 155                 160
 Ile Leu Ser Thr Trp Ile Arg Val Thr Val Arg Ile Pro Val Ser His
                 165                 170                 175    
 Pro Val Leu Thr Phe Arg Ala Pro Arg Ala His Thr Val Val Gly Asp
             180                 185                 190        
 Leu Leu Glu Leu His Cys Glu Ser Leu Arg Gly Ser Pro Pro Ile Leu
         195                 200                 205            
 Tyr Arg Phe Tyr His Glu Asp Val Thr Leu Gly Asn Ser Ser Ala Pro
     210                 215                 220                
 Ser Gly Gly Gly Ala Ser Phe Asn Leu Ser Leu Thr Ala Glu His Ser
 225                 230                 235                 240
 Gly Asn Tyr Ser Cys Asp Ala Asp Asn Gly Leu Gly Ala Gln His Ser
                 245                 250                 255    
 His Gly Val Ser Leu Arg Val Thr Val Pro Val Ser Arg Pro Ile Leu
             260                 265                 270        
 Thr Leu Arg Ala Pro Arg Ala Gln Ala Val Val Gly Asp Leu Leu Glu
         275                 280                 285            
 Leu His Cys Glu Ala Pro Arg Gly Ser Pro Pro Ile Leu Tyr Trp Phe
     290                 295                 300                
 Tyr His Glu Asp Val Thr Leu Gly Ser Ser Ser Ala Pro Leu Glu Glu
 305                 310                 315                 320
 Lys Leu Leu Ser Thr Ser Leu
                 325        



      <210> 459
      <211> 785
      <212> PRT
      <213> Homo sapiens


      <400> 459
 Met Phe His Ser Ser Ala Met Val Asn Ser His Arg Lys Pro Met Phe
   1               5                  10                  15    
 Asn Ile His Arg Gly Phe Tyr Cys Leu Thr Ala Ile Leu Pro Gln Ile
              20                  25                  30        
 Cys Ile Cys Ser Gln Phe Ser Val Pro Ser Ser Tyr His Phe Thr Glu
          35                  40                  45            
 Asp Pro Gly Ala Phe Pro Val Ala Thr Asn Gly Glu Arg Phe Pro Trp
      50                  55                  60                
 Gln Glu Leu Arg Leu Pro Ser Val Val Ile Pro Leu His Tyr Asp Leu
  65                  70                  75                  80
 Phe Val His Pro Asn Leu Thr Ser Leu Asp Phe Val Ala Ser Glu Lys
                  85                  90                  95    
 Ile Glu Val Leu Val Ser Asn Ala Thr Gln Phe Ile Ile Leu His Ser
             100                 105                 110        
 Lys Asp Leu Glu Ile Thr Asn Ala Thr Leu Gln Ser Glu Glu Asp Ser
         115                 120                 125            
 Arg Tyr Met Lys Pro Gly Lys Glu Leu Lys Val Leu Ser Tyr Pro Ala
     130                 135                 140                
 His Glu Gln Ile Ala Leu Leu Val Pro Glu Lys Leu Thr Pro His Leu
 145                 150                 155                 160
 Lys Tyr Tyr Val Ala Met Asp Phe Gln Ala Lys Leu Gly Asp Gly Phe
                 165                 170                 175    
 Glu Gly Phe Tyr Lys Ser Thr Tyr Arg Thr Leu Gly Gly Glu Thr Arg
             180                 185                 190        
 Ile Leu Ala Val Thr Asp Phe Glu Pro Thr Gln Ala Arg Met Ala Phe
         195                 200                 205            
 Pro Cys Phe Asp Glu Pro Leu Phe Lys Ala Asn Phe Ser Ile Lys Ile
     210                 215                 220                
 Arg Arg Glu Ser Arg His Ile Ala Leu Ser Asn Met Pro Lys Val Lys
 225                 230                 235                 240
 Thr Ile Glu Leu Glu Gly Gly Leu Leu Glu Asp His Phe Glu Thr Thr
                 245                 250                 255    
 Val Lys Met Ser Thr Tyr Leu Val Ala Tyr Ile Val Cys Asp Phe His
             260                 265                 270        
 Ser Leu Ser Gly Phe Thr Ser Ser Gly Val Lys Val Ser Ile Tyr Ala
         275                 280                 285            
 Ser Pro Asp Lys Arg Asn Gln Thr His Tyr Ala Leu Gln Ala Ser Leu
     290                 295                 300                
 Lys Leu Leu Asp Phe Tyr Glu Lys Tyr Phe Asp Ile Tyr Tyr Pro Leu
 305                 310                 315                 320
 Ser Lys Leu Asp Leu Ile Ala Ile Pro Asp Phe Ala Pro Gly Ala Met
                 325                 330                 335    
 Glu Asn Trp Gly Leu Ile Thr Tyr Arg Glu Thr Ser Leu Leu Phe Asp
             340                 345                 350        
 Pro Lys Thr Ser Ser Ala Ser Asp Lys Leu Trp Val Thr Arg Val Ile
         355                 360                 365            
 Ala His Glu Leu Ala His Gln Trp Phe Gly Asn Leu Val Thr Met Glu
     370                 375                 380                
 Trp Trp Asn Asp Ile Trp Leu Lys Glu Gly Phe Ala Lys Tyr Met Glu
 385                 390                 395                 400
 Leu Ile Ala Val Asn Ala Thr Tyr Pro Glu Leu Gln Phe Asp Asp Tyr
                 405                 410                 415    
 Phe Leu Asn Val Cys Phe Glu Val Ile Thr Lys Asp Ser Leu Asn Ser
             420                 425                 430        
 Ser Arg Pro Ile Ser Lys Pro Ala Glu Thr Pro Thr Gln Ile Gln Glu
         435                 440                 445            
 Met Phe Asp Glu Val Ser Tyr Asn Lys Gly Ala Cys Ile Leu Asn Met
     450                 455                 460                
 Leu Lys Asp Phe Leu Gly Glu Glu Lys Phe Gln Lys Gly Ile Ile Gln
 465                 470                 475                 480
 Tyr Leu Lys Lys Phe Ser Tyr Arg Asn Ala Asn Asn Asp Asp Leu Trp
                 485                 490                 495    
 Ser Ser Leu Ser Asn Ser Cys Leu Glu Ser Asp Phe Thr Ser Gly Gly
             500                 505                 510        
 Val Cys His Ser Asp Pro Lys Met Thr Ser Asn Met Leu Ala Phe Leu
         515                 520                 525            
 Gly Glu Asn Ala Glu Val Lys Glu Met Met Thr Thr Trp Thr Leu Gln
     530                 535                 540                
 Lys Gly Ile Pro Leu Leu Val Val Lys Gln Asp Gly Cys Ser Leu Arg
 545                 550                 555                 560
 Leu Gln Gln Glu Arg Phe Leu Gln Gly Val Phe Gln Glu Asp Pro Glu
                 565                 570                 575    
 Trp Arg Ala Leu Gln Glu Arg Tyr Leu Trp His Ile Pro Leu Thr Tyr
             580                 585                 590        
 Ser Thr Ser Ser Ser Asn Val Ile His Arg His Ile Leu Lys Ser Lys
         595                 600                 605            
 Thr Asp Thr Leu Asp Leu Pro Glu Lys Thr Ser Trp Val Lys Phe Asn
     610                 615                 620                
 Val Asp Ser Asn Gly Tyr Tyr Ile Val His Tyr Glu Gly His Gly Trp
 625                 630                 635                 640
 Asp Gln Leu Ile Thr Gln Leu Asn Gln Asn His Thr Leu Leu Arg Pro
                 645                 650                 655    
 Lys Asp Arg Val Gly Leu Ile His Asp Val Phe Gln Leu Val Gly Ala
             660                 665                 670        
 Gly Arg Leu Thr Leu Asp Lys Ala Leu Asp Met Thr Tyr Tyr Leu Gln
         675                 680                 685            
 His Glu Thr Ser Ser Pro Ala Leu Leu Glu Gly Leu Ser Tyr Leu Glu
     690                 695                 700                
 Ser Phe Tyr His Met Met Asp Arg Arg Asn Ile Ser Asp Ile Ser Glu
 705                 710                 715                 720
 Asn Leu Lys Arg Tyr Leu Leu Gln Tyr Phe Lys Pro Val Ile Asp Arg
                 725                 730                 735    
 Gln Ser Trp Ser Asp Lys Gly Ser Val Trp Asp Arg Met Leu Arg Ser
             740                 745                 750        
 Ala Leu Leu Lys Leu Ala Cys Asp Leu Asn His Ala Pro Cys Ile Gln
         755                 760                 765            
 Lys Ala Ala Glu Leu Phe Phe Gln Trp Met Glu Ser Ser Gly Lys Leu
     770                 775                 780                
 Lys
 785



      <210> 460
      <211> 92
      <212> PRT
      <213> Homo sapiens


      <400> 460
 Met Val Gln Ala Pro Lys Lys His Ser Val Ser Gly Ser Tyr Phe Leu
   1               5                  10                  15    
 Leu Phe Phe Glu Thr Arg Ser Val Thr Gln Ala Gly Val Gln Arg His
              20                  25                  30        
 Asp His Gly Ser Leu Gln Ser Gln Pro Pro Arg Leu Lys Arg Ser Ser
          35                  40                  45            
 His Leu Ser Leu Gln Ser Ser Trp Asp His Arg Cys Val Pro Ser His
      50                  55                  60                
 Ser Ala Asn Phe Lys Ile Met Asn Ile Cys Arg Gly Glu Val Ser Leu
  65                  70                  75                  80
 Arg Cys Pro Gly Trp Ser Arg Ala Pro Asp Leu Lys
                  85                  90        



      <210> 461
      <211> 1427
      <212> PRT
      <213> Homo sapiens


      <400> 461
 Met Gly Lys Pro Leu Ser Arg Pro Asp Cys Leu Arg Arg Asn Pro Ser
   1               5                  10                  15    
 Cys Leu Gly Lys Gly Glu Glu Glu Asp Gly Tyr Ile Glu Asp Cys Tyr
              20                  25                  30        
 Val Pro Gln Arg Ser Ile Tyr Asp Thr Met Arg Ile Asn Glu Gln Ile
          35                  40                  45            
 Asp Gln Gly Ser Lys Leu Asn Gln Thr Ser Lys Ser Thr Met Glu Lys
      50                  55                  60                
 Met Glu Gly Ser Thr Ile Ser Ser Asn Gly Thr Leu Gly Ala Ala Ser
  65                  70                  75                  80
 Asn Val Phe Glu Ser Arg Ala Pro Glu Gly Lys Lys Leu Asp Glu Arg
                  85                  90                  95    
 Ile Ile Phe Asp Ala Leu Lys Leu Ser Ser Asp Val Gln Lys Ser Ala
             100                 105                 110        
 Pro Val Pro Pro Arg Arg Arg Pro Asn Ala Glu Arg Lys Asp Asn Val
         115                 120                 125            
 Asn Arg Arg Ser Trp Lys Ser Phe Met Pro Pro Asn Phe Pro Glu Phe
     130                 135                 140                
 Ala Glu Arg Ile Glu Ala Ser Leu Ser Glu Val Ser Glu Ala Gly Ala
 145                 150                 155                 160
 Ser Asn Pro Ser Leu Gln Glu Lys Lys Glu Ser Ser Ser Ala Leu Thr
                 165                 170                 175    
 Glu Ser Ser Gly His Leu Asp His Arg Glu Pro Gln Ser Glu Ser Val
             180                 185                 190        
 Thr Leu Glu His Val Ser Lys Ser Ile Gly Ile Pro Glu Val Gln Asp
         195                 200                 205            
 Phe Lys Asn Leu Ser Gly Asp Cys Gln Asp Phe Arg Phe Gln Gln His
     210                 215                 220                
 Ser Ala Asn Pro Pro His Glu Phe Gln Pro Val Glu Ser Glu Ala Val
 225                 230                 235                 240
 Ala Thr Ser Gly Asn Thr Asp Val Met Gln Glu Ser Arg Phe Ser Ser
                 245                 250                 255    
 Ala Thr Trp Pro Arg Ala Thr Lys Ser Leu Ala Lys Gly Gly Phe Ser
             260                 265                 270        
 Glu Lys Gln His Pro Leu Gly Asp Thr Ala Cys Thr Val Glu Met Pro
         275                 280                 285            
 Pro Leu Ser Pro Cys Leu Ser Glu Glu Leu Leu Asp Pro Glu Leu His
     290                 295                 300                
 Val Leu Ile Thr Pro Ser Leu Arg Glu Lys Thr Glu Ser Glu Leu Lys
 305                 310                 315                 320
 Phe Glu Glu Asp Glu Arg Trp Ile Met Met Glu Ala Glu Gly Glu Trp
                 325                 330                 335    
 Glu Glu Glu Lys Leu Ser Asp Arg Glu Lys Thr Phe Leu Val Ala Asp
             340                 345                 350        
 Glu Lys Asn Ser Leu Ala Asp Ile Phe Glu Glu Arg Glu Gln Ala Asn
         355                 360                 365            
 Thr Ala Val Val Glu Asp Gly Ser Asp Cys Leu Ala Ala Val Leu Arg
     370                 375                 380                
 Thr Phe Gly His Leu Ser Leu Gly Gln Ile Cys Cys Pro Asp Asp Pro
 385                 390                 395                 400
 Gln Pro Ala Lys Asp Gln Leu Ala Thr Val Pro Lys Asp Ile Pro Leu
                 405                 410                 415    
 Asp Cys Asp Cys Val Leu Thr Gly Glu Asp Ile Leu Gly Glu Val Ala
             420                 425                 430        
 Asn Arg Thr Ala Gln Gly Leu Glu Gly Leu Val Ser Asp Ser Ala Cys
         435                 440                 445            
 Thr Val Gly Thr Ile Asp Ala Glu Gln Leu Ser Asp Thr Asp Ser Val
     450                 455                 460                
 Gln Met Phe Leu Glu Leu Glu Lys Glu Cys Leu Cys Glu Glu Gly Val
 465                 470                 475                 480
 Thr Pro Leu Val Glu Leu Gln Asn Gln Ile Ser Ser Glu Gly Leu Ala
                 485                 490                 495    
 Ala Ser Gln Asp Ala Glu Asn Leu Leu Val Ile Ser His Phe Ser Gly
             500                 505                 510        
 Ala Ala Leu Glu Lys Glu Gln His Leu Gly Leu Leu His Val Arg Ala
         515                 520                 525            
 Lys Asp Tyr Asp Thr Arg Leu Asp Cys Gly Tyr Phe Asn Thr Leu Asp
     530                 535                 540                
 Ser Ser Gln Val Pro Asn Ala Val Glu Leu Ile Ala His Val Asp Ile
 545                 550                 555                 560
 Met Arg Asp Thr Ser Thr Val Ser Lys Glu Glu Cys Glu Lys Val Pro
                 565                 570                 575    
 Phe Ser Pro Arg Thr Ala Glu Phe Lys Ser Arg Gln Pro Ala Asp Leu
             580                 585                 590        
 Asp Ser Leu Glu Lys Leu Asp Pro Gly Gly Leu Leu Asn Ser Asp His
         595                 600                 605            
 Arg Val Ser His Glu Glu Lys Leu Ser Gly Phe Ile Ala Ser Glu Leu
     610                 615                 620                
 Ala Lys Asp Asn Gly Ser Leu Ser Gln Gly Asp Cys Ser Gln Thr Glu
 625                 630                 635                 640
 Gly Asn Gly Glu Glu Cys Ile Glu Arg Val Thr Phe Ser Phe Ala Phe
                 645                 650                 655    
 Asn His Glu Leu Thr Asp Val Thr Ser Gly Pro Glu Val Glu Val Leu
             660                 665                 670        
 Tyr Glu Ser Asn Leu Leu Thr Asp Glu Ile His Leu Glu Ser Gly Asn
         675                 680                 685            
 Val Thr Val Asn Gln Glu Asn Asn Ser Leu Thr Ser Met Gly Asn Val
     690                 695                 700                
 Val Thr Cys Glu Leu Ser Val Glu Lys Val Cys Asp Glu Asp Gly Glu
 705                 710                 715                 720
 Ala Lys Glu Leu Asp Tyr Gln Ala Thr Leu Leu Glu Asp Gln Ala Pro
                 725                 730                 735    
 Ala His Phe His Arg Asn Phe Pro Glu Gln Val Phe Gln Asp Leu Gln
             740                 745                 750        
 Arg Lys Ser Pro Glu Ser Glu Ile Leu Ser Leu His Leu Leu Val Glu
         755                 760                 765            
 Glu Leu Arg Leu Asn Pro Asp Gly Val Glu Thr Val Asn Asp Thr Lys
     770                 775                 780                
 Pro Glu Leu Asn Val Ala Ser Ser Glu Gly Gly Glu Met Glu Arg Arg
 785                 790                 795                 800
 Asp Ser Asp Ser Phe Leu Asn Ile Phe Pro Glu Lys Gln Val Thr Lys
                 805                 810                 815    
 Ala Gly Asn Thr Glu Pro Val Leu Glu Glu Trp Ile Pro Val Leu Gln
             820                 825                 830        
 Arg Pro Ser Arg Thr Ala Ala Val Pro Thr Val Lys Asp Ala Leu Asp
         835                 840                 845            
 Ala Ala Leu Pro Ser Pro Glu Glu Gly Thr Ser Ile Ala Ala Val Pro
     850                 855                 860                
 Ala Pro Glu Gly Thr Ala Val Val Ala Ala Leu Val Pro Phe Pro His
 865                 870                 875                 880
 Glu Asp Ile Leu Val Ala Ser Ile Val Ser Leu Glu Glu Glu Asp Val
                 885                 890                 895    
 Thr Ala Ala Ala Val Ser Ala Pro Glu Arg Ala Thr Val Pro Ala Val
             900                 905                 910        
 Thr Val Ser Val Pro Glu Gly Thr Ala Ala Val Ala Ala Val Ser Ser
         915                 920                 925            
 Pro Glu Glu Thr Ala Pro Ala Val Ala Ala Ala Ile Thr Gln Glu Gly
     930                 935                 940                
 Met Ser Ala Val Ala Gly Phe Ser Pro Glu Trp Ala Ala Leu Ala Ile
 945                 950                 955                 960
 Thr Val Pro Ile Thr Glu Glu Asp Gly Thr Pro Glu Gly Pro Val Thr
                 965                 970                 975    
 Pro Ala Thr Thr Val His Ala Pro Glu Glu Pro Asp Thr Ala Ala Val
             980                 985                 990        
 Arg Val Ser Thr Pro Glu Glu Pro Ala Ser Pro Ala Ala Ala Val Pro
         995                1000                1005            
 Thr Pro Glu Glu Pro Thr Ser Pro Ala Ala Ala Val Pro Thr Pro Glu
    1010                1015                1020                
 Glu Pro Thr Ser Pro Ala Ala Ala Val Pro Pro Pro Glu Glu Pro Thr
1025                1030                1035                1040
 Ser Pro Ala Ala Ala Val Pro Thr Pro Glu Glu Pro Thr Ser Pro Ala
                1045                1050                1055    
 Ala Ala Val Pro Thr Pro Glu Glu Pro Thr Ser Pro Ala Ala Ala Val
            1060                1065                1070        
 Pro Thr Pro Glu Glu Pro Thr Ser Pro Ala Ala Ala Val Pro Thr Pro
        1075                1080                1085            
 Glu Glu Pro Thr Ser Pro Ala Ala Ala Val Pro Thr Pro Glu Glu Pro
    1090                1095                1100                
 Thr Ser Pro Ala Ala Ala Val Pro Thr Pro Glu Glu Pro Ala Ser Pro
1105                1110                1115                1120
 Ala Ala Ala Val Pro Thr Pro Glu Glu Pro Ala Ser Pro Ala Ala Ala
                1125                1130                1135    
 Val Pro Thr Pro Glu Glu Pro Ala Phe Pro Ala Pro Ala Val Pro Thr
            1140                1145                1150        
 Pro Glu Glu Ser Ala Ser Ala Ala Val Ala Val Pro Thr Pro Glu Glu
        1155                1160                1165            
 Ser Ala Ser Pro Ala Ala Ala Val Pro Thr Pro Ala Glu Ser Ala Ser
    1170                1175                1180                
 Phe Ala Ala Val Val Ala Thr Leu Glu Glu Pro Thr Ser Pro Ala Ala
1185                1190                1195                1200
 Ser Val Pro Thr Pro Ala Ala Met Val Ala Thr Leu Glu Glu Phe Thr
                1205                1210                1215    
 Ser Pro Ala Ala Ser Val Pro Thr Ser Glu Glu Pro Ala Ser Leu Ala
            1220                1225                1230        
 Ala Ala Val Ser Asn Pro Glu Glu Pro Thr Ser Pro Ala Ala Ala Val
        1235                1240                1245            
 Pro Thr Leu Glu Glu Pro Thr Ser Ser Ala Ala Ala Val Leu Thr Pro
    1250                1255                1260                
 Glu Glu Leu Ser Ser Pro Ala Ala Ser Val Pro Thr Pro Glu Glu Pro
1265                1270                1275                1280
 Ala Ser Pro Ala Ala Ala Val Ser Asn Leu Glu Glu Pro Ala Ser Pro
                1285                1290                1295    
 Ala Ala Ala Val Pro Thr Pro Glu Val Ala Ala Ile Pro Ala Ala Ser
            1300                1305                1310        
 Val Pro Thr Pro Glu Val Pro Ala Ile Pro Ala Ala Ala Val Pro Pro
        1315                1320                1325            
 Met Glu Glu Val Ser Pro Ile Gly Val Pro Phe Leu Gly Val Ser Ala
    1330                1335                1340                
 His Thr Asp Ser Val Pro Ile Ser Glu Glu Gly Thr Pro Val Leu Glu
1345                1350                1355                1360
 Glu Ala Ser Ser Thr Gly Met Trp Ile Lys Glu Asp Leu Asp Ser Leu
                1365                1370                1375    
 Val Phe Gly Ile Lys Glu Val Thr Ser Thr Val Leu His Gly Lys Val
            1380                1385                1390        
 Pro Leu Ala Ala Thr Ala Gly Leu Asn Ser Asp Glu Val Ile Val His
        1395                1400                1405            
 Phe Asp Ser Gly Lys Gly Leu Lys Ser Lys Val Arg Phe Ala Gly Leu
    1410                1415                1420                
 Thr Trp Trp
1425        



      <210> 462
      <211> 360
      <212> PRT
      <213> Homo sapiens


      <400> 462
 Met Ala Gly His Leu Ala Ser Asp Phe Ala Phe Ser Pro Pro Pro Gly
   1               5                  10                  15    
 Gly Gly Gly Asp Gly Pro Gly Gly Pro Glu Pro Gly Trp Val Asp Pro
              20                  25                  30        
 Arg Thr Trp Leu Ser Phe Gln Gly Pro Pro Gly Gly Pro Gly Ile Gly
          35                  40                  45            
 Pro Gly Val Gly Pro Gly Ser Glu Val Trp Gly Ile Pro Pro Cys Pro
      50                  55                  60                
 Pro Pro Tyr Glu Phe Cys Gly Gly Met Ala Tyr Cys Gly Pro Gln Val
  65                  70                  75                  80
 Gly Val Gly Leu Val Pro Gln Gly Gly Leu Glu Thr Ser Gln Pro Glu
                  85                  90                  95    
 Gly Glu Ala Gly Val Gly Val Glu Ser Asn Ser Asp Gly Ala Ser Pro
             100                 105                 110        
 Glu Pro Cys Thr Val Thr Pro Gly Ala Val Lys Leu Glu Lys Glu Lys
         115                 120                 125            
 Leu Glu Gln Asn Pro Glu Glu Ser Gln Asp Ile Lys Ala Leu Gln Lys
     130                 135                 140                
 Glu Leu Glu Gln Phe Ala Lys Leu Leu Lys Gln Lys Arg Ile Thr Leu
 145                 150                 155                 160
 Gly Tyr Thr Gln Ala Asp Val Gly Leu Thr Leu Gly Val Leu Phe Gly
                 165                 170                 175    
 Lys Val Phe Ser Gln Thr Thr Ile Cys Arg Phe Glu Ala Leu Gln Leu
             180                 185                 190        
 Ser Phe Lys Asn Met Cys Lys Leu Arg Pro Leu Leu Gln Lys Trp Val
         195                 200                 205            
 Glu Glu Ala Asp Asn Asn Glu Asn Leu Gln Glu Ile Cys Lys Ala Glu
     210                 215                 220                
 Thr Leu Val Gln Ala Arg Lys Arg Lys Arg Thr Ser Ile Glu Asn Arg
 225                 230                 235                 240
 Val Arg Gly Asn Leu Glu Asn Leu Phe Leu Gln Cys Pro Lys Pro Thr
                 245                 250                 255    
 Leu Gln Gln Ile Ser His Ile Ala Gln Gln Leu Gly Leu Glu Lys Asp
             260                 265                 270        
 Val Val Arg Val Trp Phe Cys Asn Arg Arg Gln Lys Gly Lys Arg Ser
         275                 280                 285            
 Ser Ser Asp Tyr Ala Gln Arg Glu Asp Phe Glu Ala Ala Gly Ser Pro
     290                 295                 300                
 Phe Ser Gly Gly Pro Val Ser Phe Pro Leu Ala Pro Gly Pro His Phe
 305                 310                 315                 320
 Gly Thr Pro Gly Tyr Gly Ser Pro His Phe Thr Ala Leu Tyr Ser Ser
                 325                 330                 335    
 Val Pro Phe Pro Glu Gly Glu Ala Phe Pro Pro Val Ser Val Thr Thr
             340                 345                 350        
 Leu Gly Ser Pro Met His Ser Asn
         355                 360



      <210> 463
      <211> 109
      <212> PRT
      <213> Homo sapiens


      <400> 463
 Met Ser Phe Asn Thr Leu Leu His His Pro Gly Ser Leu Leu His His
   1               5                  10                  15    
 Pro Gly Phe Pro Ala Pro Ser Ser Arg Leu Pro Cys Ser Ile Ile Pro
              20                  25                  30        
 Ala Ser Leu Leu His His Pro Asn Cys Arg Ala Leu Ser Phe Gln Leu
          35                  40                  45            
 Gln Arg Val Ser Ser Gln Met Ala Cys Ser Ile Ile Pro Ala Val Val
      50                  55                  60                
 Leu His His Ala Arg Ser Pro Val His His Pro Gly Pro Pro Ala Pro
  65                  70                  75                  80
 Ser Ser Trp Leu His Gly Pro Ser Ser Cys Ser Pro Leu Cys His His
                  85                  90                  95    
 Asn Arg Pro Leu His His Leu Gly Leu Arg Gly Thr Ser
             100                 105                



      <210> 464
      <211> 569
      <212> PRT
      <213> Homo sapiens


      <400> 464
 Met Phe Cys Pro Ala Asp Gln Asp Val Arg Met Thr Ser Lys Ser Pro
   1               5                  10                  15    
 Gly His Cys Ala Phe Ala Val Leu Tyr Gly Lys Asp Gly Arg Glu His
              20                  25                  30        
 Ala Thr Thr Arg Trp Pro Ile Thr Arg Asp Asp His His Asn Gln Met
          35                  40                  45            
 Met Leu Thr Tyr Ile Leu Tyr Pro Ser Arg Ala Leu Ser Gly Lys Ser
      50                  55                  60                
 Phe Gly Pro Met Ser Val Ser Ile Ala Leu Arg Ala Gln Glu Pro Leu
  65                  70                  75                  80
 Cys Lys Asp Asn Gly Pro Arg Ala Leu Arg Pro Ser Gly Asp Val Leu
                  85                  90                  95    
 Phe Leu Thr Asp Arg Thr Val Gly Gln Cys Gln Thr Leu Ala Val Thr
             100                 105                 110        
 Thr Ile Ser Pro Thr Ala Lys Val Leu Gln Pro Lys Gly Ala Ile Glu
         115                 120                 125            
 Asn Gln Leu Asp Ile Lys Val Leu His Val Pro Thr Arg Phe Arg Ser
     130                 135                 140                
 Pro Ala Gly Phe Thr Gln Trp Ile Pro His Trp Gly Cys Arg Trp Ser
 145                 150                 155                 160
 Cys Leu Pro Val Pro His Arg Val Pro Ala Leu Leu Ser Pro Trp Val
                 165                 170                 175    
 Val Asp Gly Thr Gly Cys Arg Gly Ala Gly Gly Gly Ala Arg Gln Gly
             180                 185                 190        
 Gly Ser Gly Arg Thr Gly Ala His Gly Ala Gly Gly Gly Ser Gly Met
         195                 200                 205            
 Ala Gly Cys Arg Ser Arg Ala Leu Pro His Gly Lys Ala Ala Lys Ala
     210                 215                 220                
 Arg Arg Glu Ile Gln His Ser Ala Gly Gly Pro Ala Leu Leu Gly Asp
 225                 230                 235                 240
 Pro Ala His Pro Pro Gln Pro Leu Ala Arg Val Leu Ser Pro Ser Leu
                 245                 250                 255    
 Pro Gly Ala Arg Arg Ala Gly Gln Leu Leu Arg Leu Pro Gly Arg Gln
             260                 265                 270        
 Ala His Ala His Pro Glu Leu Gln Leu Ala Arg Lys Arg Arg Thr Gln
         275                 280                 285            
 Pro Arg Phe Pro Leu Ala Pro Leu Pro Pro His Leu Pro Gly Lys His
     290                 295                 300                
 Ala Asp Gly Gln Val Val Glu Ser Val Gly Ser Asp Pro Thr Ala Ala
 305                 310                 315                 320
 Ser Arg Val Glu Cys Leu Gln Leu Pro Lys Pro Gln Trp Ala Cys Val
                 325                 330                 335    
 Thr Met Arg Phe Phe Ser Phe Ala Val His Arg Gln Leu Val Leu Ile
             340                 345                 350        
 Ser Ser Ile Arg Pro Ser Val Leu Leu Gln Gly Gln Lys Ala Phe Cys
         355                 360                 365            
 Ile Pro Gly Ser Cys Leu Ser Val Leu Glu Lys Ser Asp His Thr Trp
     370                 375                 380                
 Ala Leu Leu Asn Gly Gly Ser Ser Ser Gln Gln Met Asp Gly Glu Pro
 385                 390                 395                 400
 Glu Gly Gly Trp Ser Gly Lys Val Gly Pro Trp Arg Thr Leu Gly Asn
                 405                 410                 415    
 Lys Asn Pro Met Gly Thr Thr Trp Phe Arg Leu Cys Ser Thr Trp Leu
             420                 425                 430        
 Leu Ala Ala Asp Ala Asp Trp Asp Tyr Thr Pro Ala Leu Leu Asp Leu
         435                 440                 445            
 Gln Leu Ala Ala Cys Arg Ser Trp Asp Phe Ser Val Ser Ile Ile Met
     450                 455                 460                
 Ser Ala Asn Ser Leu Gln Glu Ile Ser Leu Ser Ile Tyr Pro Ile Gly
 465                 470                 475                 480
 Ser Val Phe Trp Arg Thr Leu Thr Asp Ile Gln Val Lys Val Ala Gly
                 485                 490                 495    
 Ala Val Ala Phe Leu Arg Gly Thr Ser Arg Gln Ser Trp Ser Pro Val
             500                 505                 510        
 Arg Phe Gly Asp Ala Ala Pro Ile Tyr Tyr Leu Asp Phe Leu Thr Glu
         515                 520                 525            
 Met Val Leu Gly Ala Pro Ala Gly Phe Tyr Pro Tyr Leu Gly Gln Arg
     530                 535                 540                
 Met His Gly Asp Gly Gly Gly Gln Ile Gln Phe Tyr Leu Glu Lys Ile
 545                 550                 555                 560
 Gly Ala Lys Pro Glu Thr Ala Lys Leu
                 565                



      <210> 465
      <211> 101
      <212> PRT
      <213> Homo sapiens


      <400> 465
 Met Cys Ile Cys Ile Tyr His Ala Ala Gly Val Ser Phe Met Leu Leu
   1               5                  10                  15    
 Ser Pro Gly Glu Val Thr Ser Thr Ile Lys Gly Gly Ser Glu Met Ala
              20                  25                  30        
 Ser Gly Phe Leu Gly Val Gly Gln Gly Pro Ala Gly Gly Phe Pro Ser
          35                  40                  45            
 Arg Cys Thr Glu Gly Ser Ala Glu Pro Thr Val Cys Arg Gly Cys Val
      50                  55                  60                
 Pro Arg Ala Leu Pro Arg Pro Pro Pro Ala Leu Ala Ser Ala Leu Gln
  65                  70                  75                  80
 Gly Gly Val Pro Ile Leu Gly Ala Val Cys His Ala His Leu Thr Gln
                  85                  90                  95    
 Val Cys Val Pro Val
             100    



      <210> 466
      <211> 626
      <212> PRT
      <213> Homo sapiens


      <400> 466
 Met Tyr Gln Gly His Met Gln Lys Ser Lys Glu Gln Gly Tyr Gly Lys
   1               5                  10                  15    
 Leu Ser Ser Asp Glu Asp Leu Glu Ile Ile Val Asp Gln Lys Gln Gly
              20                  25                  30        
 Lys Gly Ser Arg Ala Ala Asp Lys Ala Val Ala Met Val Met Lys Glu
          35                  40                  45            
 Ile Pro Arg Glu Glu Ser Ala Glu Glu Lys Pro Leu Leu Thr Met Thr
      50                  55                  60                
 Ser Gln Leu Val Asn Glu Gln Gln Glu Ser Arg Pro Leu Leu Ser Pro
  65                  70                  75                  80
 Ser Ile Asp Asp Phe Leu Cys Glu Thr Lys Ser Glu Ala Ile Ala Arg
                  85                  90                  95    
 Pro Val Thr Ser Asn Thr Ala Val Leu Thr Thr Gly Leu Asp Leu Leu
             100                 105                 110        
 Asp Leu Ser Glu Pro Val Ser Gln Thr Gln Thr Lys Ala Lys Lys Ser
         115                 120                 125            
 Glu Pro Ser Ser Lys Thr Ser Ser Leu Lys Lys Lys Ala Asp Gly Ser
     130                 135                 140                
 Asp Leu Ile Ser Thr Asp Ala Glu Gln Arg Gly Gln Pro Leu Arg Val
 145                 150                 155                 160
 Pro Glu Thr Ser Ser Leu Asp Leu Asp Ile Gln Thr Gln Leu Glu Lys
                 165                 170                 175    
 Trp Asp Asp Val Lys Phe His Gly Asp Arg Asn Thr Lys Gly His Pro
             180                 185                 190        
 Met Ala Glu Arg Lys Ser Ser Ser Ser Arg Thr Gly Ser Lys Glu Leu
         195                 200                 205            
 Leu Trp Ser Ser Glu His Arg Ser Gln Pro Glu Leu Ser Gly Gly Lys
     210                 215                 220                
 Ser Ala Leu Asn Ser Glu Ser Ala Ser Glu Leu Glu Leu Val Ala Pro
 225                 230                 235                 240
 Thr Gln Ala Arg Leu Thr Lys Glu His Arg Trp Gly Ser Ala Leu Leu
                 245                 250                 255    
 Ser Arg Asn His Ser Leu Glu Glu Glu Phe Glu Arg Ala Lys Ala Ala
             260                 265                 270        
 Val Glu Ser Asp Thr Glu Phe Trp Asp Lys Met Gln Ala Glu Trp Glu
         275                 280                 285            
 Glu Met Ala Arg Arg Asn Trp Ile Ser Glu Asn Gln Glu Ala Gln Asn
     290                 295                 300                
 Gln Val Thr Ile Ser Ala Ser Glu Lys Gly Tyr Tyr Phe His Thr Glu
 305                 310                 315                 320
 Asn Pro Phe Lys Asp Trp Pro Gly Ala Phe Glu Glu Gly Leu Lys Arg
                 325                 330                 335    
 Leu Lys Glu Gly Asp Leu Pro Val Thr Ile Leu Phe Met Glu Ala Ala
             340                 345                 350        
 Ile Leu Gln Asp Pro Gly Asp Ala Glu Ala Trp Gln Phe Leu Gly Ile
         355                 360                 365            
 Thr Gln Ala Glu Asn Glu Asn Glu Gln Ala Ala Ile Val Ala Leu Gln
     370                 375                 380                
 Arg Cys Leu Glu Leu Gln Pro Asn Asn Leu Lys Ala Leu Met Ala Leu
 385                 390                 395                 400
 Ala Val Ser Tyr Thr Asn Thr Gly His Gln Gln Asp Ala Cys Asp Ala
                 405                 410                 415    
 Leu Lys Asn Trp Ile Lys Gln Asn Pro Lys Tyr Lys Tyr Leu Val Lys
             420                 425                 430        
 Ser Lys Lys Gly Ser Pro Gly Leu Thr Arg Arg Met Ser Lys Ser Pro
         435                 440                 445            
 Val Asp Ser Ser Val Leu Glu Gly Val Lys Glu Leu Tyr Leu Glu Ala
     450                 455                 460                
 Ala His Gln Asn Gly Asp Met Ile Asp Pro Asp Leu Gln Thr Gly Leu
 465                 470                 475                 480
 Gly Val Leu Phe His Leu Ser Gly Glu Phe Asn Arg Ala Ile Asp Ala
                 485                 490                 495    
 Phe Asn Ala Ala Leu Thr Val Arg Pro Glu Asp Tyr Ser Leu Trp Asn
             500                 505                 510        
 Arg Leu Gly Ala Thr Leu Ala Asn Gly Asp Arg Ser Glu Glu Ala Val
         515                 520                 525            
 Glu Ala Tyr Thr Arg Ala Leu Glu Ile Gln Pro Gly Phe Ile Arg Ser
     530                 535                 540                
 Arg Tyr Asn Leu Gly Ile Ser Cys Ile Asn Leu Gly Ala Tyr Arg Glu
 545                 550                 555                 560
 Ala Val Ser Asn Phe Leu Thr Ala Leu Ser Leu Gln Arg Lys Ser Arg
                 565                 570                 575    
 Asn Gln Gln Gln Val Pro His Pro Ala Ile Ser Gly Asn Ile Trp Ala
             580                 585                 590        
 Ala Leu Arg Ile Ala Leu Ser Leu Met Asp Gln Pro Glu Leu Phe Gln
         595                 600                 605            
 Ala Ala Asn Leu Gly Asp Leu Asp Val Leu Leu Arg Ala Phe Asn Leu
     610                 615                 620                
 Asp Pro
 625    



      <210> 467
      <211> 82
      <212> PRT
      <213> Homo sapiens


      <400> 467
 Met Thr Gln Glu Gln Leu Glu Gln Ile Arg Leu Val Gln Lys Gln Gln
   1               5                  10                  15    
 Ile Gln Glu Lys Leu Arg Leu Gln Glu Glu Lys Arg Gln Arg Asp Leu
              20                  25                  30        
 Asp Trp Asp Arg Arg Arg Ile Gln Gly Ala Arg Ala Thr Leu Leu Phe
          35                  40                  45            
 Glu Arg Gln Gln Trp Arg Gln Gln Arg Asp Leu Arg Arg Ala Leu Asp
      50                  55                  60                
 Ser Ser Asn Leu Ser Leu Ala Lys Glu Gln His Leu Gln Lys Lys Tyr
  65                  70                  75                  80
 Met Lys
        



      <210> 468
      <211> 430
      <212> PRT
      <213> Homo sapiens


      <400> 468
 Met Val Ala Lys Leu Glu Ser Glu Cys Leu Lys Arg Gln Gly Gln Arg
   1               5                  10                  15    
 Glu Pro Gly Ser Leu Ser Arg Asn Asn Ser Phe Arg Arg Asn Val Gly
              20                  25                  30        
 Arg Val Leu Leu Ala Asn Ser Thr Gln Ala Asp Glu Gly Lys Thr Lys
          35                  40                  45            
 Lys Gly Val Leu Glu Ala Pro Asp Thr Gln Val Asn Pro Val Gly Ser
      50                  55                  60                
 Val Ser Val Asp Cys Gly Pro Ser Arg Ala Asp Arg Cys Ser Pro Lys
  65                  70                  75                  80
 Glu Asp Gln Ala Trp Asp Gly Ala Ser Gln Asp Cys Pro Pro Leu Pro
                  85                  90                  95    
 Ala Gly Val Ser Phe His Ile Asp Ser Ala Glu Leu Glu Pro Gly Ser
             100                 105                 110        
 Gln Thr Ala Val Lys Asn Ser Asn Arg Tyr Asp Val Glu Met Thr Asp
         115                 120                 125            
 Glu Leu Val Gly Leu Pro Phe Ser Ser His Thr Tyr Ser Gln Ala Ser
     130                 135                 140                
 Glu Leu Pro Thr Asp Ala Val Asp Cys Met Ser Arg Glu Leu Val Ser
 145                 150                 155                 160
 Leu Thr Ser Arg Asn Pro Asp Gln Arg Lys Glu Ser Leu Cys Ile Ser
                 165                 170                 175    
 Ile Thr Val Ser Lys Val Asp Lys Asp Gln Pro Ser Asn Leu Asn Ser
             180                 185                 190        
 Cys Glu Asp Pro Val Pro Gly Met Leu Phe Phe Leu Pro Pro Gly Gln
         195                 200                 205            
 His Leu Ser Asp Tyr Ser Gln Leu Asn Glu Ser Thr Thr Lys Glu Ser
     210                 215                 220                
 Ser Glu Ala Ser Gln Leu Glu Asp Ala Ala Gly Gly Asp Ser Ala Ser
 225                 230                 235                 240
 Glu Glu Lys Ser Gly Ser Ala Glu Pro Phe Val Leu Pro Ala Ser Ser
                 245                 250                 255    
 Val Glu Ser Thr Leu Pro Val Leu Glu Ala Ser Ser Trp Lys Lys Gln
             260                 265                 270        
 Val Ser His Asp Phe Leu Glu Thr Arg Phe Lys Ile Gln Gln Leu Leu
         275                 280                 285            
 Glu Pro Gln Gln Tyr Met Ala Phe Leu Pro His His Ile Met Val Lys
     290                 295                 300                
 Ile Phe Arg Leu Leu Pro Thr Lys Ser Leu Val Ala Leu Lys Cys Thr
 305                 310                 315                 320
 Cys Cys Tyr Phe Lys Phe Ile Ile Glu Tyr Tyr Asn Ile Arg Pro Ala
                 325                 330                 335    
 Asp Ser Arg Trp Val Arg Asp Pro Arg Tyr Arg Glu Asp Pro Cys Lys
             340                 345                 350        
 Gln Cys Lys Lys Lys Tyr Val Lys Gly Asp Val Ser Leu Cys Arg Trp
         355                 360                 365            
 His Pro Lys Pro Tyr Cys Gln Ala Leu Pro Tyr Gly Pro Gly Tyr Trp
     370                 375                 380                
 Met Cys Cys His Arg Ser Gln Lys Gly Phe Pro Gly Cys Lys Leu Gly
 385                 390                 395                 400
 Leu His Asp Asn His Trp Val Pro Ala Cys His Ser Phe Asn Arg Ala
                 405                 410                 415    
 Ile His Lys Lys Ala Lys Gly Thr Glu Ala Glu Glu Glu Tyr
             420                 425                 430



      <210> 469
      <211> 192
      <212> PRT
      <213> Homo sapiens


      <400> 469
 Met Ser Lys Leu Gly Arg Ala Ala Arg Gly Leu Arg Lys Pro Glu Val
   1               5                  10                  15    
 Gly Gly Val Ile Arg Ala Ile Val Arg Ala Gly Leu Ala Met Pro Gly
              20                  25                  30        
 Pro Pro Leu Gly Pro Val Leu Gly Gln Arg Gly Val Ser Ile Asn Gln
          35                  40                  45            
 Phe Cys Lys Glu Phe Asn Glu Arg Thr Lys Asp Ile Lys Glu Gly Ile
      50                  55                  60                
 Pro Leu Pro Thr Lys Ile Leu Val Lys Pro Asp Arg Thr Phe Glu Ile
  65                  70                  75                  80
 Lys Ile Gly Gln Pro Thr Val Ser Tyr Phe Leu Lys Ala Ala Ala Gly
                  85                  90                  95    
 Ile Glu Lys Gly Ala Arg Gln Thr Gly Lys Glu Val Ala Gly Leu Val
             100                 105                 110        
 Thr Leu Lys His Val Tyr Glu Ile Ala Arg Ile Lys Ala Gln Asp Glu
         115                 120                 125            
 Ala Phe Ala Leu Gln Asp Val Pro Leu Ser Ser Val Val Arg Ser Ile
     130                 135                 140                
 Ile Gly Ser Ala Arg Ser Leu Gly Ile Arg Val Val Lys Asp Leu Ser
 145                 150                 155                 160
 Ser Glu Glu Leu Ala Ala Phe Gln Lys Glu Arg Ala Ile Phe Leu Ala
                 165                 170                 175    
 Ala Gln Lys Glu Ala Asp Leu Ala Ala Gln Glu Glu Ala Ala Lys Lys
             180                 185                 190        





      <210> 470
      <211> 166
      <212> PRT
      <213> Homo sapiens


      <400> 470
 Met Ser Lys Leu Gly Arg Ala Ala Arg Gly Leu Arg Lys Pro Glu Arg
   1               5                  10                  15    
 Gly Val Ser Ile Asn Gln Phe Cys Lys Glu Phe Asn Glu Arg Thr Lys
              20                  25                  30        
 Asp Ile Lys Glu Gly Ile Pro Leu Pro Thr Lys Ile Leu Val Lys Pro
          35                  40                  45            
 Asp Arg Thr Phe Glu Ile Lys Ile Gly Gln Pro Thr Val Ser Tyr Phe
      50                  55                  60                
 Leu Lys Ala Ala Ala Gly Ile Glu Lys Gly Ala Arg Gln Thr Gly Lys
  65                  70                  75                  80
 Glu Val Ala Gly Leu Val Thr Leu Lys His Val Tyr Glu Ile Ala Arg
                  85                  90                  95    
 Ile Lys Ala Gln Asp Glu Ala Phe Ala Leu Gln Asp Val Pro Leu Ser
             100                 105                 110        
 Ser Val Val Arg Ser Ile Ile Gly Ser Ala Arg Ser Leu Gly Ile Arg
         115                 120                 125            
 Val Val Lys Asp Leu Ser Ser Glu Glu Leu Ala Ala Phe Gln Lys Glu
     130                 135                 140                
 Arg Ala Ile Phe Leu Ala Ala Gln Lys Glu Ala Asp Leu Ala Ala Gln
 145                 150                 155                 160
 Glu Glu Ala Ala Lys Lys
                 165    



      <210> 471
      <211> 334
      <212> PRT
      <213> Homo sapiens


      <400> 471
 Met Val Ser Pro Pro Pro Asp Tyr Pro Gly Glu Phe Phe Lys Asp Val
   1               5                  10                  15    
 Arg Gln Gly Leu Ile Gly Val Gly Leu Ile Asn Val Glu Asp Arg Ser
              20                  25                  30        
 Gly Ile Leu Thr Leu Asp Lys Asp Tyr Asn Asn Ile Gly Lys Phe Leu
          35                  40                  45            
 Asn Arg Ile Leu Gly Met Glu Val His Gln Gln Asn Glu Leu Phe Gln
      50                  55                  60                
 Tyr Phe Ala Asp Thr Leu Thr Ala Val Val Gln Asn Ala Lys Lys Asn
  65                  70                  75                  80
 Gly Arg Tyr Asp Met Gly Ile Leu Asp Leu Gly Ser Gly Asp Glu Lys
                  85                  90                  95    
 Val Arg Lys Ser Asp Val Lys Lys Phe Leu Thr Pro Gly Tyr Ser Thr
             100                 105                 110        
 Ser Gly His Val Glu Leu Tyr Thr Ile Ser Val Glu Arg Gly Met Ser
         115                 120                 125            
 Trp Glu Glu Ala Thr Lys Ile Trp Ala Glu Leu Thr Gly Pro Asp Asp
     130                 135                 140                
 Gly Phe Tyr Leu Ser Leu Gln Ile Arg Asn Asn Lys Lys Thr Ala Ile
 145                 150                 155                 160
 Leu Val Lys Glu Val Asn Pro Lys Lys Lys Leu Phe Leu Val Tyr Arg
                 165                 170                 175    
 Pro Asn Thr Gly Lys Gln Leu Lys Leu Glu Ile Tyr Ala Asp Leu Lys
             180                 185                 190        
 Lys Lys Tyr Lys Lys Val Val Ser Asp Asp Ala Leu Met His Trp Leu
         195                 200                 205            
 Asp Gln Tyr Asn Ser Ser Ala Asp Thr Cys Thr His Ala Tyr Trp Arg
     210                 215                 220                
 Gly Asn Cys Lys Lys Ala Ser Leu Gly Leu Val Cys Glu Ile Gly Leu
 225                 230                 235                 240
 Arg Phe Arg Thr Tyr Tyr Val Leu Cys Gly Ser Val Leu Ser Val Trp
                 245                 250                 255    
 Thr Lys Val Glu Gly Val Leu Ala Ser Val Ser Gly Thr Asn Val Lys
             260                 265                 270        
 Met Gln Ile Val Arg Leu Ile Thr Glu Asp Gly Gln Arg Ile Val Gly
         275                 280                 285            
 Leu Ile Ile Pro Ala Asn Cys Val Ser Pro Leu Val Asn Leu Leu Ser
     290                 295                 300                
 Thr Ser Asp Gln Ser Gln Gln Leu Ala Val Gln Gln Lys Gln Leu Trp
 305                 310                 315                 320
 Gln Gln His His Pro Gln Ser Ile Thr Asn Leu Ser Asn Ala
                 325                 330                



      <210> 472
      <211> 147
      <212> PRT
      <213> Homo sapiens


      <400> 472
 Met Pro Asp Ala Asn Pro Ser Ser Gly His Val Gln Pro Ala Gly Gln
   1               5                  10                  15    
 Pro Arg Gly Ser Leu Ser Ser Arg Ala Lys Asp Ser Arg Leu Pro Phe
              20                  25                  30        
 Ser Leu Leu Ala Phe Leu Leu Cys Pro Ala Val Ala Ala Gly Glu Ala
          35                  40                  45            
 Ala Ala Ala Gly Gly Arg Arg Ser Cys Leu Ser Ala Pro Pro Cys Pro
      50                  55                  60                
 Thr Pro Ala Pro Ala Leu Glu Ile Trp Ser Pro Leu Glu Leu Ser Trp
  65                  70                  75                  80
 Thr Gly Gly Gln Leu Arg Ala Cys Ala Leu Asn Ala Ala Leu Ser Arg
                  85                  90                  95    
 Gly Arg Glu Gln Asp Gly Glu Trp Lys Glu Ser Pro Pro Gly Phe Val
             100                 105                 110        
 Asn Cys Lys Lys Gly Pro Phe Gln Asp Asp Thr Arg Asn Arg Ala Arg
         115                 120                 125            
 Ala Leu Ala Gln Ser Leu Gly Ala Cys Leu Phe Phe Ile Ile Val Phe
     130                 135                 140                
 Lys Ser Leu
 145        



      <210> 473
      <211> 531
      <212> PRT
      <213> Homo sapiens


      <400> 473
 Met Glu Arg Ile Leu Phe Asp Pro Gln Asn Ser Thr Val Arg Lys Gln
   1               5                  10                  15    
 Ala Asp Glu Thr Thr Gln Leu Pro Thr His Ala Thr Leu Gln Glu Lys
              20                  25                  30        
 Gly Lys Thr Ala Leu Arg Val Leu Tyr Leu Lys Asn Leu Ser Pro Arg
          35                  40                  45            
 Val Thr Glu Arg Asp Leu Val Ser Leu Phe Ala Arg Phe Gln Glu Lys
      50                  55                  60                
 Lys Gly Pro Pro Ile Gln Phe Arg Met Met Thr Gly Arg Met Arg Gly
  65                  70                  75                  80
 Gln Ala Phe Ile Thr Phe Pro Asn Lys Glu Ile Ala Trp Gln Ala Leu
                  85                  90                  95    
 His Leu Val Asn Gly Tyr Lys Leu His Gly Lys Ile Leu Val Ile Glu
             100                 105                 110        
 Phe Gly Lys Asn Lys Lys Gln Arg Ser Asn Leu Gln Ala Thr Ser Leu
         115                 120                 125            
 Ile Ser Cys Ala Thr Val Leu Glu Thr Arg Ser Pro Arg Ser Arg Cys
     130                 135                 140                
 Trp Gln Val Gln Cys Leu Val Lys Ala Ile Leu Pro Phe Gln Asp Asp
 145                 150                 155                 160
 Thr Leu Leu Leu His Pro Pro Glu Gly Lys Asn Ala Ala Pro Phe Tyr
                 165                 170                 175    
 Gly Gly Gly Lys Met Ile Asn Pro Ser Cys Pro Gly Gly Leu Gly Ala
             180                 185                 190        
 Thr Val Cys Trp Thr Tyr Phe Thr His Thr Ser Met Ser Asp Gly Gly
         195                 200                 205            
 Gly Ile Gln Val Pro Pro Met Thr Ile Tyr Thr Glu Gln Asp Leu Tyr
     210                 215                 220                
 Asn His Val Val Pro Lys Pro His Asn Lys Arg Val Pro Ile Leu Pro
 225                 230                 235                 240
 Phe Val Ile Arg Ala Gly Val Leu Gly Arg Leu Gly Thr Gly Ile Gly
                 245                 250                 255    
 Ser Ile Thr Thr Ser Thr Gln Phe Tyr Tyr Lys Leu Ser Gln Glu Ile
             260                 265                 270        
 Asn Gly Asp Met Glu Gln Val Thr Asp Ser Leu Val Thr Leu Gln Asp
         275                 280                 285            
 Gln Leu Asn Ser Leu Ala Ala Val Val Leu Gln Asn Arg Arg Ala Leu
     290                 295                 300                
 Asp Leu Leu Thr Ala Lys Arg Gly Gly Thr Cys Leu Phe Leu Gly Glu
 305                 310                 315                 320
 Glu Cys Cys Tyr Tyr Val Asn Gln Ser Arg Ile Val Thr Glu Lys Val
                 325                 330                 335    
 Lys Glu Ile Arg Asp Arg Ile Gln Cys Arg Ala Glu Glu Leu Gln Asn
             340                 345                 350        
 Thr Glu His Trp Gly Leu Leu Ser Gln Trp Met Pro Trp Val Leu Pro
         355                 360                 365            
 Phe Leu Gly Pro Leu Ala Ala Leu Ile Leu Leu Leu Leu Phe Gly Pro
     370                 375                 380                
 Cys Ile Phe Asn Leu Leu Val Lys Phe Val Ser Ser Arg Ile Glu Ala
 385                 390                 395                 400
 Val Lys Leu Gln Met Val Leu Gln Met Glu Pro Gln Met Gln Ser Met
                 405                 410                 415    
 Thr Lys Ile Tyr His Gly Pro Leu Asp Gln Pro Ala Ser Pro Cys Ser
             420                 425                 430        
 Asp Val Asn Asp Ile Lys Gly Thr Pro Pro Glu Glu Ile Ser Thr Ala
         435                 440                 445            
 Gln Pro Leu Pro Cys Pro Ile Ser Ala Gly Ser Arg Lys Glu Glu Tyr
     450                 455                 460                
 Val Tyr Val Val Leu Leu Ala Phe Pro Glu Gly Ile Ile Leu Gln Ala
 465                 470                 475                 480
 Leu Gly Asn Thr Arg Lys Gly Lys Gly Glu Ser Gly Val His Gly His
                 485                 490                 495    
 Ser Phe Pro Pro Phe Trp Ser Met Glu Gln Glu Glu Asp Thr Arg Pro
             500                 505                 510        
 Ser Pro Asp Thr Lys Ser Ala Gly Ile Leu Ile Ser Ala Ser Gln Pro
         515                 520                 525            
 Leu Asn Met
     530    



      <210> 474
      <211> 224
      <212> PRT
      <213> Homo sapiens


      <400> 474
 Met Asp Leu Lys His Leu Ala Arg Arg Glu Thr Leu Met Pro Leu Ser
   1               5                  10                  15    
 Met Lys Leu Leu Gly Lys Leu Leu Trp Gln Met Pro Phe Ser Leu Ile
              20                  25                  30        
 Lys Gln Thr Leu Val Pro Glu Glu Asp Val Lys Lys Leu Arg Ala Thr
          35                  40                  45            
 Ile Arg Ser Ile Asn Gly Leu Gly Gln Ile Leu Glu Thr Gln Arg Ser
      50                  55                  60                
 Arg Val Asp Leu Ser Asn Val Leu Asp Leu His Ala Phe Asp Ser Leu
  65                  70                  75                  80
 Ser Gly Ile Ser Leu Gln Lys Lys Leu Gln His Val Pro Gly Thr Gln
                  85                  90                  95    
 Pro His Leu Asp Gln Ser Ile Val Thr Ile Thr Phe Glu Val Pro Gly
             100                 105                 110        
 Asn Ala Lys Glu Glu His Leu Asn Met Phe Ile Gln Asn Leu Leu Trp
         115                 120                 125            
 Glu Lys Asn Val Arg Asn Lys Asp Asn His Cys Met Glu Val Ile Arg
     130                 135                 140                
 Leu Lys Gly Leu Val Ser Ile Lys Asp Lys Ser Gln Gln Val Ile Val
 145                 150                 155                 160
 Gln Gly Val His Glu Leu Tyr Asp Leu Glu Glu Thr Pro Val Ser Trp
                 165                 170                 175    
 Lys Asp Asp Thr Glu Arg Thr Asn Arg Leu Val Leu Leu Gly Arg Asn
             180                 185                 190        
 Leu Asp Lys Asp Ile Leu Lys Gln Leu Phe Ile Ala Thr Val Thr Glu
         195                 200                 205            
 Thr Glu Lys Gln Trp Thr Thr His Phe Lys Glu Asp Gln Val Cys Thr
     210                 215                 220                





      <210> 475
      <211> 179
      <212> PRT
      <213> Homo sapiens


      <400> 475
 Met Gly Cys Cys Tyr Ser Ser Glu Asn Glu Asp Ser Asp Gln Asp Arg
   1               5                  10                  15    
 Glu Glu Arg Lys Leu Leu Leu Asp Pro Ser Ser Pro Pro Thr Lys Ala
              20                  25                  30        
 Leu Asn Gly Ala Glu Pro Asn Tyr His Ser Leu Pro Ser Ala Arg Thr
          35                  40                  45            
 Asp Glu Gln Ala Leu Leu Ser Ser Ile Leu Ala Lys Thr Ala Ser Asn
      50                  55                  60                
 Ile Ile Asp Val Ser Ala Ala Asp Ser Gln Gly Met Glu Gln His Glu
  65                  70                  75                  80
 Tyr Met Asp Arg Ala Arg Gln Tyr Ser Thr Arg Leu Ala Val Leu Ser
                  85                  90                  95    
 Ser Ser Leu Thr His Trp Lys Lys Leu Pro Pro Leu Pro Ser Leu Thr
             100                 105                 110        
 Ser Gln Pro His Gln Val Leu Ala Ser Glu Pro Ile Pro Phe Ser Asp
         115                 120                 125            
 Leu Gln Gln Val Ser Arg Ile Ala Ala Tyr Ala Tyr Ser Ala Leu Ser
     130                 135                 140                
 Gln Ile Arg Val Asp Ala Lys Glu Glu Leu Val Val Gln Phe Gly Asp
 145                 150                 155                 160
 Pro Met Lys Lys Arg Gly Pro Gly Lys Ala Pro Leu Pro Leu Leu Ser
                 165                 170                 175    
 Pro His Phe
            



      <210> 476
      <211> 963
      <212> PRT
      <213> Homo sapiens


      <400> 476
 Met Asp Ala Pro Lys Ala Gly Tyr Ala Phe Glu Tyr Leu Ile Glu Thr
   1               5                  10                  15    
 Leu Asn Asp Ser Ser His Lys Lys Phe Phe Asp Val Ser Lys Leu Gly
              20                  25                  30        
 Thr Lys Tyr Asp Val Leu Pro Tyr Ser Ile Arg Val Leu Leu Glu Ala
          35                  40                  45            
 Ala Val Arg Asn Cys Asp Gly Phe Leu Met Lys Lys Glu Asp Val Met
      50                  55                  60                
 Asn Ile Leu Asp Trp Lys Thr Lys Gln Ser Asn Val Glu Val Pro Phe
  65                  70                  75                  80
 Phe Pro Ala Arg Val Leu Leu Gln Asp Phe Thr Gly Ile Pro Ala Met
                  85                  90                  95    
 Val Asp Phe Ala Ala Met Arg Glu Ala Val Lys Thr Leu Gly Gly Asp
             100                 105                 110        
 Pro Glu Lys Val His Pro Ala Cys Pro Thr Asp Leu Thr Val Asp His
         115                 120                 125            
 Ser Leu Gln Ile Asp Phe Ser Lys Cys Ala Ile Gln Asn Ala Pro Asn
     130                 135                 140                
 Pro Gly Gly Gly Asp Leu Gln Lys Ala Gly Lys Leu Ser Pro Leu Lys
 145                 150                 155                 160
 Val Gln Pro Lys Lys Leu Pro Cys Arg Gly Gln Thr Thr Cys Arg Gly
                 165                 170                 175    
 Ser Cys Asp Ser Gly Glu Leu Gly Arg Asn Ser Gly Thr Phe Ser Ser
             180                 185                 190        
 Gln Ile Glu Asn Thr Pro Ile Leu Cys Pro Phe His Leu Gln Pro Val
         195                 200                 205            
 Pro Glu Pro Glu Thr Val Leu Lys Asn Gln Glu Val Glu Phe Gly Arg
     210                 215                 220                
 Asn Arg Glu Arg Leu Gln Phe Phe Lys Trp Ser Ser Arg Val Leu Lys
 225                 230                 235                 240
 Asn Val Ala Val Ile Pro Pro Gly Thr Gly Met Ala His Gln Ile Asn
                 245                 250                 255    
 Leu Glu Tyr Leu Ser Arg Val Val Phe Glu Glu Lys Asp Leu Leu Phe
             260                 265                 270        
 Pro Asp Ser Val Val Gly Thr Asp Ser His Ile Thr Met Val Asn Gly
         275                 280                 285            
 Leu Gly Ile Leu Gly Trp Gly Val Gly Gly Ile Glu Thr Glu Ala Val
     290                 295                 300                
 Met Leu Gly Leu Pro Val Ser Leu Thr Leu Pro Glu Val Val Gly Cys
 305                 310                 315                 320
 Glu Leu Thr Gly Ser Ser Asn Pro Phe Val Thr Ser Ile Asp Val Val
                 325                 330                 335    
 Leu Gly Ile Thr Lys His Leu Arg Gln Val Gly Val Ala Gly Lys Phe
             340                 345                 350        
 Val Glu Phe Phe Gly Ser Gly Val Ser Gln Leu Ser Ile Val Asp Arg
         355                 360                 365            
 Thr Thr Ile Ala Asn Met Cys Pro Glu Tyr Gly Ala Ile Leu Ser Phe
     370                 375                 380                
 Phe Pro Val Asp Asn Val Thr Leu Lys His Leu Glu His Thr Gly Phe
 385                 390                 395                 400
 Ser Lys Ala Lys Leu Glu Ser Met Glu Thr Tyr Leu Lys Ala Val Lys
                 405                 410                 415    
 Leu Phe Arg Asn Asp Gln Asn Ser Ser Gly Glu Pro Glu Tyr Ser Gln
             420                 425                 430        
 Val Ile Gln Ile Asn Leu Asn Ser Ile Val Pro Ser Val Ser Gly Pro
         435                 440                 445            
 Lys Arg Pro Arg Asp Arg Val Ala Val Thr Asp Met Lys Ser Asp Phe
     450                 455                 460                
 Gln Ala Cys Leu Asn Glu Lys Val Gly Phe Lys Gly Phe Gln Ile Ala
 465                 470                 475                 480
 Ala Glu Lys Gln Lys Asp Ile Val Ser Ile His Tyr Glu Gly Ser Glu
                 485                 490                 495    
 Tyr Lys Leu Ser His Gly Ser Val Val Ile Ala Ala Val Ile Ser Cys
             500                 505                 510        
 Thr Asn Asn Cys Asn Pro Ser Val Met Leu Ala Ala Gly Leu Leu Ala
         515                 520                 525            
 Lys Lys Ala Val Glu Ala Gly Leu Arg Val Lys Pro Tyr Ile Arg Thr
     530                 535                 540                
 Ser Leu Ser Pro Gly Ser Gly Met Val Thr His Tyr Leu Ser Ser Ser
 545                 550                 555                 560
 Gly Val Leu Pro Tyr Leu Ser Lys Leu Gly Phe Glu Ile Val Gly Tyr
                 565                 570                 575    
 Gly Cys Ser Thr Cys Val Gly Asn Thr Ala Pro Leu Ser Asp Ala Val
             580                 585                 590        
 Leu Asn Ala Val Lys Gln Gly Asp Leu Val Thr Cys Gly Asn Phe Ile
         595                 600                 605            
 Trp Lys Lys Asn Phe Glu Gly Arg Leu Cys Asp Cys Val Arg Ala Asn
     610                 615                 620                
 Tyr Leu Ala Ser Pro Pro Leu Val Val Ala Tyr Ala Ile Ala Gly Thr
 625                 630                 635                 640
 Val Asn Ile Asp Phe Gln Thr Glu Pro Leu Gly Thr Asp Pro Thr Gly
                 645                 650                 655    
 Lys Asn Ile Tyr Leu His Asp Ile Trp Pro Ser Arg Glu Glu Val His
             660                 665                 670        
 Arg Val Glu Glu Glu His Val Ile Leu Ser Met Phe Lys Ala Leu Lys
         675                 680                 685            
 Asp Lys Ile Glu Met Gly Asn Lys Arg Trp Asn Ser Leu Glu Ala Pro
     690                 695                 700                
 Asp Ser Val Leu Phe Pro Trp Asp Leu Lys Ser Thr Tyr Ile Arg Cys
 705                 710                 715                 720
 Pro Ser Phe Phe Asp Lys Leu Thr Lys Glu Pro Ile Ala Leu Gln Ala
                 725                 730                 735    
 Ile Glu Asn Ala His Val Leu Leu Tyr Leu Gly Asp Ser Val Thr Thr
             740                 745                 750        
 Asp His Ile Ser Pro Ala Gly Ser Ile Ala Arg Asn Ser Ala Ala Ala
         755                 760                 765            
 Lys Tyr Leu Thr Asn Arg Gly Leu Thr Pro Arg Glu Phe Asn Ser Tyr
     770                 775                 780                
 Gly Ala Arg Arg Gly Asn Asp Ala Val Met Thr Arg Gly Thr Phe Ala
 785                 790                 795                 800
 Asn Ile Lys Leu Phe Asn Lys Phe Ile Gly Lys Pro Ala Pro Lys Thr
                 805                 810                 815    
 Ile His Phe Pro Ser Gly Gln Thr Leu Asp Val Phe Glu Ala Ala Glu
             820                 825                 830        
 Leu Tyr Gln Lys Glu Gly Ile Pro Leu Ile Ile Leu Ala Gly Lys Lys
         835                 840                 845            
 Tyr Gly Ser Gly Asn Ser Arg Asp Trp Ala Ala Lys Gly Pro Tyr Leu
     850                 855                 860                
 Leu Gly Val Lys Ala Val Leu Ala Glu Ser Tyr Glu Lys Ile His Lys
 865                 870                 875                 880
 Asp His Leu Ile Gly Ile Gly Ile Ala Pro Leu Gln Phe Leu Pro Gly
                 885                 890                 895    
 Glu Asn Ala Asp Ser Leu Gly Leu Ser Gly Arg Glu Thr Phe Ser Leu
             900                 905                 910        
 Thr Phe Pro Glu Glu Leu Ser Pro Gly Ile Thr Leu Asn Ile Gln Thr
         915                 920                 925            
 Ser Thr Gly Lys Val Phe Ser Val Ile Ala Ser Phe Glu Asp Asp Val
     930                 935                 940                
 Glu Ile Thr Leu Tyr Lys His Gly Gly Leu Leu Asn Phe Val Ala Arg
 945                 950                 955                 960
 Lys Phe Ser
            



      <210> 477
      <211> 140
      <212> PRT
      <213> Homo sapiens


      <400> 477
 Met Val His Leu Thr Pro Glu Glu Lys Ser Ala Val Thr Ala Leu Trp
   1               5                  10                  15    
 Gly Lys Val Asn Val Asp Glu Val Gly Gly Glu Ala Leu Gly Arg Leu
              20                  25                  30        
 Leu Val Val Tyr Pro Trp Thr Gln Arg Phe Phe Glu Ser Phe Gly Asp
          35                  40                  45            
 Leu Ser Thr Pro Asp Ala Val Met Gly Asn Pro Lys Val Lys Ala His
      50                  55                  60                
 Gly Lys Lys Val Leu Gly Ala Phe Ser Asp Gly Leu Ala His Leu Asp
  65                  70                  75                  80
 Asn Leu Lys Gly Thr Phe Ala Thr Leu Ser Glu Leu His Cys Asp Lys
                  85                  90                  95    
 Leu His Val Asp Pro Glu Asn Phe Arg Leu Leu Gly Gln Arg Ala Gly
             100                 105                 110        
 Leu Cys Ala Gly Pro Ile Thr Leu Gly Lys Glu Phe His Pro Thr Ser
         115                 120                 125            
 Ala Gly Cys Leu Ser Glu Ser Gly Gly Trp Cys Gly
     130                 135                 140



      <210> 478
      <211> 140
      <212> PRT
      <213> Homo sapiens


      <400> 478
 Met Ser Gly Ser Phe Tyr Phe Val Ile Val Gly His His Asp Asn Pro
   1               5                  10                  15    
 Val Phe Glu Met Glu Phe Leu Pro Ala Gly Lys Ala Glu Ser Lys Asp
              20                  25                  30        
 Asp His Arg His Leu Asn Gln Phe Ile Ala His Ala Ala Leu Asp Leu
          35                  40                  45            
 Val Asp Glu Asn Met Trp Leu Ser Asn Asn Met Tyr Leu Lys Thr Val
      50                  55                  60                
 Asp Lys Phe Asn Glu Trp Phe Val Ser Ala Phe Val Thr Ala Gly His
  65                  70                  75                  80
 Met Arg Phe Ile Met Leu His Asp Ile Arg Gln Glu Asp Gly Ile Lys
                  85                  90                  95    
 Asn Phe Phe Thr Asp Val Tyr Asp Leu Tyr Ile Lys Phe Ser Met Asn
             100                 105                 110        
 Pro Phe Tyr Glu Pro Asn Ser Pro Ile Arg Ser Ser Ala Phe Asp Arg
         115                 120                 125            
 Lys Val Gln Phe Leu Gly Lys Lys His Leu Leu Ser
     130                 135                 140



      <210> 479
      <211> 236
      <212> PRT
      <213> Homo sapiens


      <400> 479
 Met Arg Leu Ala Gly Gln Val Arg Gln Gly Pro Gly Asp Phe Val Gln
   1               5                  10                  15    
 Leu Pro Val Pro Val Ile Gln Gln Leu Tyr His Trp Asp Cys Gly Leu
              20                  25                  30        
 Ala Cys Ser Arg Met Val Leu Arg Tyr Leu Gly Gln Leu Asp Asp Ser
          35                  40                  45            
 Glu Phe Glu Arg Ala Leu Gln Lys Leu Gln Leu Thr Arg Ser Ile Trp
      50                  55                  60                
 Thr Ile Asp Leu Ala Tyr Leu Met His His Phe Gly Val Arg His Arg
  65                  70                  75                  80
 Phe Cys Thr Gln Thr Leu Gly Val Asp Lys Gly Tyr Lys Asn Gln Ser
                  85                  90                  95    
 Phe Tyr Arg Lys His Phe Asp Thr Glu Glu Thr Arg Val Asn Gln Leu
             100                 105                 110        
 Phe Ala Gln Ala Lys Ala Cys Lys Val Leu Val Glu Lys Cys Thr Val
         115                 120                 125            
 Ser Val Lys Asp Ile Gln Ala His Leu Ala Gln Gly His Val Ala Ile
     130                 135                 140                
 Val Leu Val Asn Ser Gly Val Leu His Cys Asp Leu Cys Ser Ser Pro
 145                 150                 155                 160
 Val Lys Tyr Cys Cys Phe Thr Pro Ser Gly His His Cys Phe Cys Arg
                 165                 170                 175    
 Thr Pro Asp Tyr Gln Gly His Phe Ile Val Leu Arg Gly Tyr Asn Arg
             180                 185                 190        
 Ala Thr Gly Cys Ile Phe Tyr Asn Asn Pro Ala Tyr Ala Asp Arg Met
         195                 200                 205            
 Cys Ser Thr Ser Ile Ser Asn Phe Glu Glu Ala Arg Thr Ser Tyr Gly
     210                 215                 220                
 Thr Asp Glu Asp Ile Leu Phe Val Tyr Leu Asp Ser
 225                 230                 235    



      <210> 480
      <211> 198
      <212> PRT
      <213> Homo sapiens


      <400> 480
 Met Thr Ser Glu Ile Thr Tyr Ala Glu Val Arg Phe Lys Asn Glu Phe
   1               5                  10                  15    
 Lys Ser Ser Gly Ile Asn Thr Ala Ser Ser Ala Val Phe Phe Gln Lys
              20                  25                  30        
 Tyr Ser Gln Leu Leu Glu Lys Lys Thr Thr Lys Glu Leu Val His Thr
          35                  40                  45            
 Thr Leu Glu Cys Val Lys Lys Asn Met Pro Val Glu Glu Thr Ala Trp
      50                  55                  60                
 Ser Cys Cys Pro Lys Asn Trp Lys Ser Phe Ser Ser Asn Cys Tyr Phe
  65                  70                  75                  80
 Ile Ser Thr Glu Ser Ala Ser Trp Gln Asp Ser Glu Lys Asp Cys Ala
                  85                  90                  95    
 Arg Met Glu Ala His Leu Leu Val Ile Asn Thr Gln Glu Glu Gln Asp
             100                 105                 110        
 Phe Ile Phe Gln Asn Leu Gln Glu Glu Ser Ala Tyr Phe Val Gly Leu
         115                 120                 125            
 Ser Asp Pro Glu Gly Gln Arg His Trp Gln Trp Val Asp Gln Thr Pro
     130                 135                 140                
 Tyr Asn Glu Ser Ser Thr Phe Trp His Pro Arg Glu Pro Ser Asp Pro
 145                 150                 155                 160
 Asn Glu Arg Cys Val Val Leu Asn Phe Arg Lys Ser Pro Lys Arg Trp
                 165                 170                 175    
 Gly Trp Asn Asp Val Asn Cys Leu Gly Pro Gln Arg Ser Val Cys Glu
             180                 185                 190        
 Met Met Lys Ile His Leu
         195            



      <210> 481
      <211> 186
      <212> PRT
      <213> Homo sapiens


      <400> 481
 Met Val Tyr Leu Gly Ala Met Thr Asn Phe Asp Val Thr Tyr Asn Trp
   1               5                  10                  15    
 Ile Gln Asp Lys Cys Val Pro Leu Val Arg Glu Ile Thr Phe Glu Asn
              20                  25                  30        
 Gly Glu Glu Leu Thr Glu Glu Gly Leu Pro Phe Leu Ile Leu Phe His
          35                  40                  45            
 Met Lys Glu Asp Thr Glu Ser Leu Glu Ile Phe Gln Asn Glu Val Ala
      50                  55                  60                
 Arg Gln Leu Ile Ser Glu Lys Gly Thr Ile Asn Phe Leu His Ala Asp
  65                  70                  75                  80
 Cys Asp Lys Phe Arg His Pro Leu Leu His Ile Gln Lys Thr Pro Ala
                  85                  90                  95    
 Asp Cys Pro Val Ile Ala Ile Asp Ser Phe Arg His Met Tyr Val Phe
             100                 105                 110        
 Gly Asp Phe Lys Asp Val Leu Ile Pro Gly Lys Leu Lys Gln Phe Val
         115                 120                 125            
 Phe Asp Leu His Ser Gly Lys Leu His Arg Glu Phe His His Gly Pro
     130                 135                 140                
 Asp Pro Thr Asp Thr Ala Pro Gly Glu Gln Ala Gln Asp Val Ala Ser
 145                 150                 155                 160
 Ser Pro Pro Glu Ser Ser Phe Gln Lys Leu Ala Pro Ser Glu Tyr Arg
                 165                 170                 175    
 Tyr Thr Leu Leu Arg Asp Arg Asp Glu Leu
             180                 185    



      <210> 482
      <211> 1231
      <212> PRT
      <213> Homo sapiens


      <400> 482
 Met Val Leu Leu Trp Glu Pro Ala Gly Ala Trp Leu Ala Leu Gly Leu
   1               5                  10                  15    
 Ala Leu Ala Leu Gly Pro Ser Val Ala Ala Ala Ala Pro Arg Gln Asp
              20                  25                  30        
 Cys Thr Gly Val Glu Cys Pro Pro Leu Glu Thr Cys Ile Glu Glu Ala
          35                  40                  45            
 Leu Glu Pro Gly Ala Cys Cys Ala Thr Cys Val Gln Gln Gly Cys Ala
      50                  55                  60                
 Cys Glu Gly Tyr Gln Tyr Tyr Asp Cys Leu Gln Gly Gly Phe Val Arg
  65                  70                  75                  80
 Gly Arg Val Pro Ala Gly Gln Ser Tyr Phe Val Asp Phe Gly Ser Thr
                  85                  90                  95    
 Glu Cys Ser Cys Pro Pro Gly Gly Gly Lys Ile Ser Cys Gln Phe Met
             100                 105                 110        
 Leu Cys Pro Glu Leu Pro Pro Asn Cys Ile Glu Ala Val Val Val Ala
         115                 120                 125            
 Asp Ser Cys Pro Gln Cys Gly Gln Val Gly Cys Val His Ala Gly His
     130                 135                 140                
 Glu Tyr Ala Ala Gly His Thr Val His Leu Pro Pro Cys Arg Ala Cys
 145                 150                 155                 160
 His Cys Pro Asp Ala Gly Gly Glu Leu Ile Cys Tyr Gln Leu Pro Gly
                 165                 170                 175    
 Cys His Gly Asn Phe Ser Asp Ala Glu Glu Gly Asp Pro Glu Arg His
             180                 185                 190        
 Tyr Glu Asp Pro Tyr Ser Tyr Asp Gln Glu Val Ala Glu Val Glu Ala
         195                 200                 205            
 Ala Thr Ala Leu Gly Gly Glu Val Gln Ala Gly Ala Val Gln Ala Gly
     210                 215                 220                
 Ala Gly Gly Pro Pro Ala Ala Leu Gly Gly Gly Ser Gln Pro Leu Ser
 225                 230                 235                 240
 Thr Ile Gln Ala Pro Pro Trp Pro Ala Val Leu Pro Arg Pro Thr Ala
                 245                 250                 255    
 Ala Ala Ala Leu Gly Pro Pro Ala Pro Val Gln Ala Lys Ala Arg Arg
             260                 265                 270        
 Val Thr Glu Asp Ser Glu Glu Glu Glu Glu Glu Glu Glu Glu Arg Glu
         275                 280                 285            
 Glu Met Ala Val Thr Glu Gln Leu Ala Ala Gly Gly His Arg Gly Leu
     290                 295                 300                
 Asp Gly Leu Pro Thr Thr Ala Pro Ala Gly Pro Ser Leu Pro Ile Gln
 305                 310                 315                 320
 Glu Glu Arg Ala Glu Ala Gly Ala Arg Ala Glu Ala Gly Ala Arg Pro
                 325                 330                 335    
 Glu Glu Asn Leu Ile Leu Asp Ala Gln Ala Thr Ser Arg Ser Thr Gly
             340                 345                 350        
 Pro Glu Gly Val Thr His Ala Pro Ser Leu Gly Lys Ala Ala Leu Val
         355                 360                 365            
 Pro Thr Gln Ala Val Pro Gly Ser Pro Arg Asp Pro Val Lys Pro Ser
     370                 375                 380                
 Pro His Asn Ile Leu Ser Thr Ser Leu Pro Asp Ala Ala Trp Ile Pro
 385                 390                 395                 400
 Pro Thr Arg Glu Val Pro Arg Lys Pro Gln Val Leu Pro His Ser His
                 405                 410                 415    
 Val Glu Glu Asp Thr Asp Pro Asn Ser Val His Ser Ile Pro Arg Ser
             420                 425                 430        
 Ser Pro Glu Gly Ser Thr Lys Asp Leu Ile Glu Thr Cys Cys Ala Ala
         435                 440                 445            
 Gly Gln Gln Trp Ala Ile Asp Asn Asp Glu Cys Leu Glu Ile Pro Glu
     450                 455                 460                
 Ser Gly Thr Glu Asp Asn Val Cys Arg Thr Ala Gln Arg His Cys Cys
 465                 470                 475                 480
 Val Ser Tyr Leu Gln Glu Lys Ser Cys Met Ala Gly Val Leu Gly Ala
                 485                 490                 495    
 Lys Glu Gly Glu Thr Cys Gly Ala Glu Asp Asn Asp Ser Cys Gly Ile
             500                 505                 510        
 Ser Leu Tyr Lys Gln Cys Cys Asp Cys Cys Gly Leu Gly Leu Arg Val
         515                 520                 525            
 Arg Ala Glu Gly Gln Ser Cys Glu Ser Asn Pro Asn Leu Gly Tyr Pro
     530                 535                 540                
 Cys Asn His Val Met Leu Ser Cys Cys Glu Gly Glu Glu Pro Leu Ile
 545                 550                 555                 560
 Val Pro Glu Val Arg Arg Pro Pro Glu Pro Ala Ala Ala Pro Arg Arg
                 565                 570                 575    
 Val Ser Glu Ala Glu Met Ala Gly Arg Glu Ala Leu Ser Leu Gly Thr
             580                 585                 590        
 Glu Ala Glu Leu Pro Asn Ser Leu Pro Gly Asp Asp Gln Asp Glu Cys
         595                 600                 605            
 Leu Leu Leu Pro Gly Glu Leu Cys Gln His Leu Cys Ile Asn Thr Val
     610                 615                 620                
 Gly Ser Tyr His Cys Ala Cys Phe Pro Gly Phe Ser Leu Gln Asp Asp
 625                 630                 635                 640
 Gly Arg Thr Cys Arg Pro Glu Gly His Pro Pro Gln Pro Glu Ala Pro
                 645                 650                 655    
 Gln Glu Pro Ala Leu Lys Ser Glu Phe Ser Gln Val Ala Ser Asn Thr
             660                 665                 670        
 Ile Pro Leu Pro Leu Pro Gln Pro Asn Thr Cys Lys Asp Asn Gly Pro
         675                 680                 685            
 Cys Lys Gln Val Cys Ser Thr Val Gly Gly Ser Ala Ile Cys Ser Cys
     690                 695                 700                
 Phe Pro Gly Tyr Ala Ile Met Ala Asp Gly Val Ser Cys Glu Asp Gln
 705                 710                 715                 720
 Asp Glu Cys Leu Met Gly Ala His Asp Cys Ser Arg Arg Gln Phe Cys
                 725                 730                 735    
 Val Asn Thr Leu Gly Ser Phe Tyr Cys Val Asn His Thr Val Leu Cys
             740                 745                 750        
 Ala Asp Gly Tyr Ile Leu Asn Ala His Arg Lys Cys Val Asp Ile Asn
         755                 760                 765            
 Glu Cys Val Thr Asp Leu His Thr Cys Ser Arg Gly Glu His Cys Val
     770                 775                 780                
 Asn Thr Leu Gly Ser Phe His Cys Tyr Lys Ala Leu Thr Cys Glu Pro
 785                 790                 795                 800
 Gly Tyr Ala Leu Lys Asp Gly Glu Cys Glu Asp Val Asp Glu Cys Ala
                 805                 810                 815    
 Met Gly Thr His Thr Cys Gln Pro Gly Phe Leu Cys Gln Asn Thr Lys
             820                 825                 830        
 Gly Ser Phe Tyr Cys Gln Ala Arg Gln Arg Cys Met Asp Gly Phe Leu
         835                 840                 845            
 Gln Asp Pro Glu Gly Asn Cys Val Asp Ile Asn Glu Cys Thr Ser Leu
     850                 855                 860                
 Ser Glu Pro Cys Arg Pro Gly Phe Ser Cys Ile Asn Thr Val Gly Ser
 865                 870                 875                 880
 Tyr Thr Cys Gln Arg Asn Pro Leu Ile Cys Ala Arg Gly Tyr His Ala
                 885                 890                 895    
 Ser Asp Asp Gly Ala Lys Cys Val Asp Val Asn Glu Cys Glu Thr Gly
             900                 905                 910        
 Val His Arg Cys Gly Glu Gly Gln Val Cys His Asn Leu Pro Gly Ser
         915                 920                 925            
 Tyr Arg Cys Asp Cys Lys Ala Gly Phe Gln Arg Asp Ala Phe Gly Arg
     930                 935                 940                
 Gly Cys Ile Asp Val Asn Glu Cys Trp Ala Ser Pro Gly Arg Leu Cys
 945                 950                 955                 960
 Gln His Thr Cys Glu Asn Thr Leu Gly Ser Tyr Arg Cys Ser Cys Ala
                 965                 970                 975    
 Ser Gly Phe Leu Leu Ala Ala Asp Gly Lys Arg Cys Glu Asp Val Asn
             980                 985                 990        
 Glu Cys Glu Ala Gln Arg Cys Ser Gln Glu Cys Ala Asn Ile Tyr Gly
         995                1000                1005            
 Ser Tyr Gln Cys Tyr Cys Arg Gln Gly Tyr Gln Leu Ala Glu Asp Gly
    1010                1015                1020                
 His Thr Cys Thr Asp Ile Asp Glu Cys Ala Gln Gly Ala Gly Ile Leu
1025                1030                1035                1040
 Cys Thr Phe Arg Cys Leu Asn Val Pro Gly Ser Tyr Gln Cys Ala Cys
                1045                1050                1055    
 Pro Glu Gln Gly Tyr Thr Met Thr Ala Asn Gly Arg Ser Cys Lys Asp
            1060                1065                1070        
 Val Asp Glu Cys Ala Leu Gly Thr His Asn Cys Ser Glu Ala Glu Thr
        1075                1080                1085            
 Cys His Asn Ile Gln Gly Ser Phe Arg Cys Leu Arg Phe Glu Cys Pro
    1090                1095                1100                
 Pro Asn Tyr Val Gln Val Ser Lys Thr Lys Cys Glu Arg Thr Thr Cys
1105                1110                1115                1120
 His Asp Phe Leu Glu Cys Gln Asn Ser Pro Ala Arg Ile Thr His Tyr
                1125                1130                1135    
 Gln Leu Asn Phe Gln Thr Gly Leu Leu Val Pro Ala His Ile Phe Arg
            1140                1145                1150        
 Ile Gly Pro Ala Pro Ala Phe Thr Gly Asp Thr Ile Ala Leu Asn Ile
        1155                1160                1165            
 Ile Lys Gly Asn Glu Glu Gly Tyr Phe Gly Thr Arg Arg Leu Asn Ala
    1170                1175                1180                
 Tyr Thr Gly Val Val Tyr Leu Gln Arg Ala Val Leu Glu Pro Arg Asp
1185                1190                1195                1200
 Phe Ala Leu Asp Val Glu Met Lys Leu Trp Arg Gln Gly Ser Val Thr
                1205                1210                1215    
 Thr Phe Leu Ala Lys Met His Ile Phe Phe Thr Thr Phe Ala Leu
            1220                1225                1230    



      <210> 483
      <211> 257
      <212> PRT
      <213> Homo sapiens


      <400> 483
 Met Val Ser Pro Val Ser Lys Asp Ala Thr Glu Asp Leu Arg Lys Ala
   1               5                  10                  15    
 Thr Gly Pro Leu Glu Ala Gln Ala Leu Val Lys Gln Asp Leu Leu Pro
              20                  25                  30        
 Ala Asp Gln Ala Gln Val Leu Asn Glu Met Ala Lys Tyr Gln Val Pro
          35                  40                  45            
 Gln Arg Ser Gly Asp Ile Val Met Ile Gln Ser Glu His Thr Gly Ala
      50                  55                  60                
 Ile Asp Val Leu Ser Ala Asp Leu Glu Ser Ala Asp Leu Leu Gly Asp
  65                  70                  75                  80
 His Arg Lys Val Ser Pro Pro Leu Met Ala Pro Pro Cys Ile Trp Thr
                  85                  90                  95    
 Phe Ala Lys Val Lys Glu Phe Lys Ser Lys Leu Gly Lys Glu Lys Asn
             100                 105                 110        
 Ser Arg Leu Val Val Lys Arg Gly Glu Val Val Thr Ile Arg Val Pro
         115                 120                 125            
 Thr His Pro Glu Gly Lys Arg Val Cys Trp Glu Phe Ala Thr Asp Asp
     130                 135                 140                
 Tyr Asp Ile Gly Phe Gly Val Tyr Phe Asp Trp Thr Pro Val Thr Ser
 145                 150                 155                 160
 Thr Asp Ile Thr Val Gln Val Ser Asp Ser Ser Asp Asp Glu Asp Glu
                 165                 170                 175    
 Glu Glu Glu Glu Glu Glu Glu Ile Glu Glu Pro Val Pro Ala Gly Asp
             180                 185                 190        
 Val Glu Arg Gly Ser Arg Ser Ser Leu Arg Gly Arg Tyr Gly Glu Val
         195                 200                 205            
 Met Pro Val Tyr Arg Arg Asp Ser His Arg Asp Val Gln Ala Gly Ser
     210                 215                 220                
 His Asp Tyr Pro Gly Glu Gly Ile Tyr Leu Leu Lys Phe Asp Asn Ser
 225                 230                 235                 240
 Tyr Ser Leu Leu Arg Asn Lys Thr Leu Tyr Phe His Ile Tyr Tyr Thr
                 245                 250                 255    
 Ser
    



      <210> 484
      <211> 245
      <212> PRT
      <213> Homo sapiens


      <400> 484
 Met Ala Leu Ala Leu Cys Leu Gln Val Leu Cys Ser Leu Cys Gly Trp
   1               5                  10                  15    
 Leu Ser Leu Tyr Ile Ser Phe Cys His Leu Asn Lys His Arg Ser Tyr
              20                  25                  30        
 Glu Trp Ser Cys Arg Leu Val Thr Phe Thr His Gly Val Leu Ser Ile
          35                  40                  45            
 Gly Leu Ser Ala Tyr Ile Gly Phe Ile Asp Gly Pro Trp Pro Phe Thr
      50                  55                  60                
 His Pro Gly Ser Pro Asn Thr Pro Leu Gln Val His Val Leu Cys Leu
  65                  70                  75                  80
 Thr Leu Gly Tyr Phe Ile Phe Asp Leu Gly Trp Cys Val Tyr Phe Gln
                  85                  90                  95    
 Ser Glu Gly Ala Leu Met Leu Ala His His Thr Leu Ser Ile Leu Gly
             100                 105                 110        
 Ile Ile Met Ala Leu Val Leu Gly Glu Ser Gly Thr Glu Val Asn Ala
         115                 120                 125            
 Val Leu Phe Gly Ser Glu Leu Thr Asn Pro Leu Leu Gln Met Arg Trp
     130                 135                 140                
 Phe Leu Arg Glu Thr Gly His Tyr His Ser Phe Thr Gly Asp Val Val
 145                 150                 155                 160
 Asp Phe Leu Phe Val Ala Leu Phe Thr Gly Val Arg Ile Gly Val Gly
                 165                 170                 175    
 Ala Cys Leu Leu Phe Cys Glu Met Val Ser Pro Thr Pro Lys Trp Phe
             180                 185                 190        
 Val Lys Ala Gly Gly Val Ala Met Tyr Ala Val Ser Trp Cys Phe Met
         195                 200                 205            
 Phe Ser Ile Trp Arg Phe Ala Trp Arg Lys Ser Ile Lys Lys Tyr His
     210                 215                 220                
 Ala Trp Arg Ser Arg Arg Ser Glu Glu Arg Gln Leu Lys His Asn Gly
 225                 230                 235                 240
 His Leu Lys Ile His
                 245



      <210> 485
      <211> 86
      <212> PRT
      <213> Homo sapiens


      <400> 485
 Met Val Val Pro Ala Ala Leu Lys Val Val Arg Leu Lys Pro Thr Arg
   1               5                  10                  15    
 Lys Phe Ala Tyr Leu Gly Arg Leu Ala His Glu Val Gly Trp Lys Tyr
              20                  25                  30        
 Gln Ala Val Thr Ala Thr Leu Glu Glu Lys Arg Lys Glu Lys Ala Lys
          35                  40                  45            
 Ile His Tyr Arg Lys Lys Lys Gln Leu Met Arg Leu Arg Lys Gln Ala
      50                  55                  60                
 Glu Lys Asn Val Glu Lys Lys Ile Asp Lys Tyr Thr Glu Val Leu Lys
  65                  70                  75                  80
 Thr His Gly Leu Leu Val
                  85    



      <210> 486
      <211> 558
      <212> PRT
      <213> Homo sapiens


      <400> 486
 Met Ser Ala Thr Ser Val Asp Thr Gln Arg Thr Lys Gly Gln Asp Asn
   1               5                  10                  15    
 Lys Val Gln Asn Gly Ser Leu His Gln Lys Asp Thr Val His Asp Asn
              20                  25                  30        
 Asp Phe Glu Pro Tyr Leu Thr Gly Gln Ala Asn Gln Ser Asn Ser Tyr
          35                  40                  45            
 Pro Ser Met Ser Asp Pro Tyr Leu Ser Ser Tyr Tyr Pro Pro Ser Ile
      50                  55                  60                
 Gly Phe Pro Tyr Ser Leu Asn Glu Ala Pro Trp Ser Thr Ala Gly Asp
  65                  70                  75                  80
 Pro Pro Ile Pro Tyr Leu Thr Thr Tyr Gly Gln Leu Ser Asn Gly Asp
                  85                  90                  95    
 His His Phe Met His Asp Ala Val Phe Gly Gln Pro Gly Gly Leu Gly
             100                 105                 110        
 Asn Asn Ile Tyr Gln His Arg Phe Asn Phe Phe Pro Glu Asn Pro Ala
         115                 120                 125            
 Phe Ser Ala Trp Gly Thr Ser Gly Ser Gln Gly Gln Gln Thr Gln Ser
     130                 135                 140                
 Ser Ala Tyr Gly Ser Ser Tyr Thr Tyr Pro Pro Ser Ser Leu Gly Gly
 145                 150                 155                 160
 Thr Val Val Asp Gly Gln Pro Gly Phe His Ser Asp Thr Leu Ser Lys
                 165                 170                 175    
 Ala Pro Gly Met Asn Ser Leu Glu Gln Gly Met Val Gly Leu Lys Ile
             180                 185                 190        
 Gly Asp Val Ser Ser Ser Ala Val Lys Thr Val Gly Ser Val Val Ser
         195                 200                 205            
 Ser Val Ala Leu Thr Gly Val Leu Ser Gly Asn Gly Gly Thr Asn Val
     210                 215                 220                
 Asn Met Pro Val Ser Lys Pro Thr Ser Trp Ala Ala Ile Ala Ser Lys
 225                 230                 235                 240
 Pro Ala Lys Pro Gln Pro Lys Met Lys Thr Lys Ser Gly Pro Val Met
                 245                 250                 255    
 Gly Gly Gly Leu Pro Pro Pro Pro Ile Lys His Asn Met Asp Ile Gly
             260                 265                 270        
 Thr Trp Asp Asn Lys Gly Pro Val Pro Lys Ala Ser Pro Pro Ala Gly
         275                 280                 285            
 Thr Leu Ser Thr Gly Cys Pro Thr Ala Pro Ala Gly Gly Ser Ala Leu
     290                 295                 300                
 Pro Ala Gln Pro Pro Ala Leu Ala Gln Pro Gln Tyr Gln Ser Pro Gln
 305                 310                 315                 320
 Gln Pro Pro Gln Thr Arg Trp Val Ala Pro Arg Asn Arg Asn Ala Ala
                 325                 330                 335    
 Phe Gly Gln Ser Gly Gly Ala Gly Ser Asp Thr Asn Ser Pro Gly Asn
             340                 345                 350        
 Val Gln Pro Asn Ser Ala Pro Ser Val Glu Ser His Pro Val Leu Glu
         355                 360                 365            
 Lys Leu Lys Ala Ala His Ser Tyr Asn Pro Lys Glu Phe Glu Trp Asn
     370                 375                 380                
 Leu Lys Ser Gly Arg Val Phe Ile Ile Lys Ser Tyr Ser Glu Asp Asp
 385                 390                 395                 400
 Ile His Arg Ser Ile Lys Tyr Ser Ile Trp Cys Ser Thr Glu His Gly
                 405                 410                 415    
 Asn Lys Arg Leu Asp Ser Ala Phe Arg Cys Met Ser Ser Lys Gly Pro
             420                 425                 430        
 Val Tyr Leu Leu Phe Ser Val Asn Gly Ser Gly His Phe Cys Gly Val
         435                 440                 445            
 Ala Glu Met Lys Ser Pro Val Asp Tyr Gly Thr Ser Ala Gly Val Trp
     450                 455                 460                
 Ser Gln Asp Lys Trp Lys Gly Lys Phe Asp Val Gln Trp Ile Phe Val
 465                 470                 475                 480
 Lys Asp Val Pro Asn Asn Gln Leu Arg His Ile Arg Leu Glu Asn Asn
                 485                 490                 495    
 Asp Asn Lys Pro Val Thr Asn Ser Arg Asp Thr Gln Glu Val Pro Leu
             500                 505                 510        
 Glu Lys Ala Lys Gln Val Leu Lys Ile Ile Ser Ser Tyr Lys His Thr
         515                 520                 525            
 Thr Ser Ile Phe Asp Asp Phe Ala His Tyr Glu Lys Arg Gln Glu Glu
     530                 535                 540                
 Glu Glu Val Val Arg Lys Glu Arg Gln Ser Arg Asn Lys Gln
 545                 550                 555            



      <210> 487
      <211> 338
      <212> PRT
      <213> Homo sapiens


      <400> 487
 Met Ala Ser Arg Leu Leu His Arg His Ile Arg Glu Gln Leu Lys Asp
   1               5                  10                  15    
 Leu Val Glu Ile Leu Gln Asp Pro Ser Pro Pro Pro Leu Cys Leu Pro
              20                  25                  30        
 Thr Thr Pro Gly Thr Pro Asp Ser Ser Asp Pro Ser His Leu Leu Gly
          35                  40                  45            
 Pro Gln Ser Cys Trp Ser Ser Gln Lys Glu Val Ser His Glu Ser Leu
      50                  55                  60                
 Val Val Gly Ala Ile Glu Asn Ala Phe Gln Leu Met Asp Glu Gln Met
  65                  70                  75                  80
 Ala Arg Glu Arg Arg Gly His Gln Val Glu Gly Gly Cys Cys Ala Leu
                  85                  90                  95    
 Val Val Ile Tyr Leu Leu Gly Lys Val Tyr Val Ala Asn Ala Gly Asp
             100                 105                 110        
 Ser Arg Ala Ile Ile Val Arg Asn Gly Glu Ile Ile Pro Met Ser Arg
         115                 120                 125            
 Glu Phe Thr Pro Glu Thr Glu Arg Gln Arg Leu Gln Leu Leu Gly Phe
     130                 135                 140                
 Leu Lys Pro Glu Leu Leu Gly Ser Glu Phe Thr His Leu Glu Phe Pro
 145                 150                 155                 160
 Arg Arg Val Leu Pro Lys Glu Leu Gly Gln Arg Met Leu Tyr Arg Asp
                 165                 170                 175    
 Gln Asn Met Thr Gly Trp Ala Tyr Lys Lys Ile Glu Leu Glu Asp Leu
             180                 185                 190        
 Arg Phe Pro Leu Val Cys Gly Glu Gly Lys Lys Ala Arg Val Met Ala
         195                 200                 205            
 Thr Ile Gly Val Thr Arg Gly Leu Gly Asp His Ser Leu Lys Val Cys
     210                 215                 220                
 Ser Ser Thr Leu Pro Ile Lys Pro Phe Leu Ser Cys Phe Pro Glu Val
 225                 230                 235                 240
 Arg Val Tyr Asp Leu Thr Gln Tyr Glu His Cys Pro Asp Asp Val Leu
                 245                 250                 255    
 Val Leu Gly Thr Asp Gly Leu Trp Asp Val Thr Thr Asp Cys Glu Val
             260                 265                 270        
 Ala Ala Thr Val Asp Arg Val Leu Ser Ala Tyr Glu Pro Asn Asp His
         275                 280                 285            
 Ser Arg Tyr Thr Ala Leu Ala Gln Ala Leu Val Leu Gly Ala Arg Gly
     290                 295                 300                
 Thr Pro Arg Asp Arg Gly Trp Arg Leu Pro Asn Asn Lys Leu Gly Ser
 305                 310                 315                 320
 Gly Asp Asp Ile Ser Val Phe Val Ile Pro Leu Gly Gly Pro Gly Ser
                 325                 330                 335    
 Tyr Ser
        



      <210> 488
      <211> 547
      <212> PRT
      <213> Homo sapiens


      <400> 488
 Met Asp Ile Ile Phe Gly Arg Asn Arg Lys Glu Gln Leu Glu Pro Val
   1               5                  10                  15    
 Arg Ala Lys Val Thr Gly Lys Ile Pro Ala Trp Leu Gln Gly Thr Leu
              20                  25                  30        
 Leu Arg Asn Gly Pro Gly Met His Thr Val Gly Glu Ser Arg Tyr Asn
          35                  40                  45            
 His Trp Phe Asp Gly Leu Ala Leu Leu His Ser Phe Thr Ile Arg Asp
      50                  55                  60                
 Gly Glu Val Tyr Tyr Arg Ser Lys Tyr Leu Arg Ser Asp Thr Tyr Asn
  65                  70                  75                  80
 Thr Asn Ile Glu Ala Asn Arg Ile Val Val Ser Glu Phe Gly Thr Met
                  85                  90                  95    
 Ala Tyr Pro Asp Pro Cys Lys Asn Ile Phe Ser Lys Ala Phe Ser Tyr
             100                 105                 110        
 Leu Ser His Thr Ile Pro Asp Phe Thr Asp Asn Cys Leu Ile Asn Ile
         115                 120                 125            
 Met Lys Cys Gly Glu Asp Phe Tyr Ala Thr Ser Glu Thr Asn Tyr Ile
     130                 135                 140                
 Arg Lys Ile Asn Pro Gln Thr Leu Glu Thr Leu Glu Lys Val Asp Tyr
 145                 150                 155                 160
 Arg Lys Tyr Val Ala Val Asn Leu Ala Thr Ser His Pro His Tyr Asp
                 165                 170                 175    
 Glu Ala Gly Asn Val Leu Asn Met Gly Thr Ser Ile Val Glu Lys Gly
             180                 185                 190        
 Lys Thr Lys Tyr Val Ile Phe Lys Ile Pro Ala Thr Val Pro Glu Gly
         195                 200                 205            
 Lys Lys Gln Gly Lys Ser Pro Trp Lys His Thr Glu Val Phe Cys Ser
     210                 215                 220                
 Ile Pro Ser Arg Ser Leu Leu Ser Pro Ser Tyr Tyr His Ser Phe Gly
 225                 230                 235                 240
 Val Thr Glu Asn Tyr Val Ile Phe Leu Glu Gln Pro Phe Arg Leu Asp
                 245                 250                 255    
 Ile Leu Lys Met Ala Thr Ala Tyr Ile Arg Arg Met Ser Trp Ala Ser
             260                 265                 270        
 Cys Leu Ala Phe His Arg Glu Glu Lys Thr Tyr Ile His Ile Ile Asp
         275                 280                 285            
 Gln Arg Thr Arg Gln Pro Val Gln Thr Lys Phe Tyr Thr Asp Ala Met
     290                 295                 300                
 Val Val Phe His His Val Asn Ala Tyr Glu Glu Asp Gly Cys Ile Val
 305                 310                 315                 320
 Phe Asp Val Ile Ala Tyr Glu Asp Asn Ser Leu Tyr Gln Leu Phe Tyr
                 325                 330                 335    
 Leu Ala Asn Leu Asn Gln Asp Phe Lys Glu Asn Ser Arg Leu Thr Ser
             340                 345                 350        
 Val Pro Thr Leu Arg Arg Phe Ala Val Pro Leu His Val Asp Lys Asn
         355                 360                 365            
 Ala Glu Val Gly Thr Asn Leu Ile Lys Val Ala Ser Thr Thr Ala Thr
     370                 375                 380                
 Ala Leu Lys Glu Glu Asp Gly Gln Val Tyr Cys Gln Pro Glu Phe Leu
 385                 390                 395                 400
 Tyr Glu Gly Leu Glu Leu Pro Arg Val Asn Tyr Ala His Asn Gly Lys
                 405                 410                 415    
 Gln Tyr Arg Tyr Val Phe Ala Thr Gly Val Gln Trp Ser Pro Ile Pro
             420                 425                 430        
 Thr Lys Ile Ile Lys Tyr Asp Ile Leu Thr Lys Ser Ser Leu Lys Trp
         435                 440                 445            
 Arg Glu Asp Asp Cys Trp Pro Ala Glu Pro Leu Phe Val Pro Ala Pro
     450                 455                 460                
 Gly Ala Lys Asp Glu Asp Asp Gly Val Ile Leu Ser Ala Ile Val Ser
 465                 470                 475                 480
 Thr Asp Pro Gln Lys Leu Pro Phe Leu Leu Ile Leu Asp Ala Lys Ser
                 485                 490                 495    
 Phe Thr Glu Leu Ala Arg Ala Ser Val Asp Val Asp Met His Met Asp
             500                 505                 510        
 Leu His Gly Leu Phe Ile Thr Asp Met Asp Trp Asp Thr Lys Lys Gln
         515                 520                 525            
 Ala Ala Ser Glu Glu Gln Arg Asp Arg Ala Ser Asp Cys His Gly Ala
     530                 535                 540                
 Pro Leu Thr
 545        



      <210> 489
      <211> 235
      <212> PRT
      <213> Homo sapiens


      <400> 489
 Met Ala Trp Ile Pro Leu Leu Leu Pro Leu Leu Thr Leu Cys Thr Gly
   1               5                  10                  15    
 Ser Glu Ala Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser
              20                  25                  30        
 Pro Gly Gln Thr Ala Arg Ile Thr Cys Ser Gly Asp Ala Leu Pro Lys
          35                  40                  45            
 Gln Tyr Ala Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu
      50                  55                  60                
 Val Ile Tyr Lys Asp Ser Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe
  65                  70                  75                  80
 Ser Gly Ser Ser Ser Gly Thr Thr Val Thr Leu Thr Ile Ser Gly Val
                  85                  90                  95    
 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Ala Asp Ser Ser
             100                 105                 110        
 Gly Thr Tyr Pro Gly Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val
         115                 120                 125            
 Leu Gly Gln Pro Lys Ala Asn Pro Thr Val Thr Leu Phe Gln Pro Ser
     130                 135                 140                
 Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser
 145                 150                 155                 160
 Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser
                 165                 170                 175    
 Pro Val Lys Ala Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn
             180                 185                 190        
 Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp
         195                 200                 205            
 Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr
     210                 215                 220                
 Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser
 225                 230                 235



      <210> 490
      <211> 610
      <212> PRT
      <213> Homo sapiens


      <400> 490
 Met Ala Ser Gly Ile Leu Val Asn Val Lys Glu Glu Val Thr Cys Pro
   1               5                  10                  15    
 Ile Cys Leu Glu Leu Leu Thr Gln Pro Leu Ser Leu Asp Cys Gly His
              20                  25                  30        
 Ser Phe Cys Gln Ala Cys Leu Thr Ala Asn His Lys Lys Ser Met Leu
          35                  40                  45            
 Asp Lys Gly Glu Ser Ser Cys Pro Val Cys Arg Ile Ser Tyr Gln Pro
      50                  55                  60                
 Glu Asn Ile Arg Pro Asn Arg His Val Ala Asn Ile Val Glu Lys Leu
  65                  70                  75                  80
 Arg Glu Val Lys Leu Ser Pro Glu Gly Gln Lys Val Asp His Cys Ala
                  85                  90                  95    
 Arg His Gly Glu Lys Leu Leu Leu Phe Cys Gln Glu Asp Gly Lys Val
             100                 105                 110        
 Ile Cys Trp Leu Cys Glu Arg Ser Gln Glu His Arg Gly His His Thr
         115                 120                 125            
 Phe Leu Thr Glu Glu Val Ala Arg Glu Tyr Gln Val Lys Leu Gln Ala
     130                 135                 140                
 Ala Leu Glu Met Leu Arg Gln Lys Gln Gln Glu Ala Glu Glu Leu Glu
 145                 150                 155                 160
 Ala Asp Ile Arg Glu Glu Lys Ala Ser Trp Lys Thr Gln Ile Gln Tyr
                 165                 170                 175    
 Asp Lys Thr Asn Val Leu Ala Asp Phe Glu Gln Leu Arg Asp Ile Leu
             180                 185                 190        
 Asp Trp Glu Glu Ser Asn Glu Leu Gln Asn Leu Glu Lys Glu Glu Glu
         195                 200                 205            
 Asp Ile Leu Lys Ser Leu Thr Asn Ser Glu Thr Glu Met Val Gln Gln
     210                 215                 220                
 Thr Gln Ser Leu Arg Glu Leu Ile Ser Asp Leu Glu His Arg Leu Gln
 225                 230                 235                 240
 Gly Ser Val Met Glu Leu Leu Gln Ala Gln Gly Glu Gly Phe Lys Cys
                 245                 250                 255    
 Ile Ser Asp Val Lys Glu Met Lys Pro Val Met Trp Glu Gly Trp Thr
             260                 265                 270        
 Gln Asp Glu Arg Cys Gly Gly Gln Lys Ile Phe Phe Ile Pro Arg Ser
         275                 280                 285            
 Glu Ile Trp Arg Leu Lys Lys Pro Lys Met Val Ser Lys Lys Leu Lys
     290                 295                 300                
 Thr Val Phe His Ala Pro Asp Leu Ser Arg Met Leu Gln Met Phe Arg
 305                 310                 315                 320
 Gly Glu Glu Lys Gln Thr Lys Thr Val Asp Val Gly Leu Leu Trp Cys
                 325                 330                 335    
 Gln Ala Val Val Val Ser Gly Gly Tyr Gly Lys Ala Leu Leu Gly Met
             340                 345                 350        
 Ser Gly Arg Met Phe Leu Val Thr Leu Gly Ser Thr Cys Glu Tyr Gln
         355                 360                 365            
 Trp Trp Cys Gln Gly Pro Gly Met Leu Val Phe Glu His Leu Gly Ser
     370                 375                 380                
 Ile His Gly Ser Trp Trp Trp Gln Met Trp Val Ser Val Leu Asp Glu
 385                 390                 395                 400
 Gly Gly Leu Tyr Val His Ile Leu Gly His Pro Ser Phe Phe Ile Leu
                 405                 410                 415    
 Gln Gly Ile Pro Gly Met Glu Asp Lys His Arg Trp Ile Ser Ile Pro
             420                 425                 430        
 Phe Ser Ser Met Tyr Phe Ile Met Val Leu Gly Asn Cys Thr Ile Leu
         435                 440                 445            
 Leu Thr Ile Ser Thr Glu Arg Ser Leu His Lys Pro Met Phe Leu Leu
     450                 455                 460                
 Leu Cys Leu Leu Ala Leu Thr Asp Leu Gly Met Ser Thr Thr Thr Ile
 465                 470                 475                 480
 Pro Lys Val Leu Cys Ile Phe Trp Phe Gly Gln Ser Glu Ile Ser Tyr
                 485                 490                 495    
 Glu Gly Cys Leu Val Gln Leu Phe Phe Ile His Ser Ile Ser Ala Met
             500                 505                 510        
 Gln Ser Ala Val Leu Met Thr Met Ala Phe Asp His Tyr Val Ala Ile
         515                 520                 525            
 Cys Lys Pro Leu Arg Tyr Ala Thr Ile Leu Ser Asn Ser Cys Thr Gly
     530                 535                 540                
 Leu Ile Gly Leu Val Ser Leu Val Arg Ala Ile Leu Phe Ile Leu Pro
 545                 550                 555                 560
 Met Pro Ile Leu Leu Gln Gln Met Pro Tyr His Ala Asn Arg Val Ile
                 565                 570                 575    
 Pro Thr Thr Ser Cys Glu His Met Ala Val Val Lys Met Val Cys Val
             580                 585                 590        
 Asp Thr Thr Val Asn Arg Ile Tyr Gly Leu Val Val Ala Leu Leu Val
         595                 600                 605            
 Ala Gly
     610

